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Early fetal growth restriction

Sonnet S Jonker, Samantha Louey, Charles E Roselli
Polycystic ovary syndrome (PCOS) is a complex and common disorder in women, and those affected experience an increased burden of cardiovascular disease. It is an intergenerational syndrome, as affected women with high androgen levels during pregnancy "program" fetal development, leading to a similar phenotype in their female offspring. The effect of excess maternal testosterone exposure on fetal cardiomyocyte growth and maturation is unknown. METHODS Pregnant ewes received biweekly injections of vehicle (Control) or 100 mg testosterone propionate between 30-59 days of gestation (dGA; Early T) or 60-90 dGA (Late T)...
August 10, 2018: American Journal of Physiology. Heart and Circulatory Physiology
Tsai-Der Chuang, Reiko Sakurai, Ming Gong, Omid Khorram, Virender K Rehan
Considerable epidemiological and experimental evidence supports the concept that the adult chronic lung disease (CLD), at least in part, is due to aberrations in early lung development in response to an abnormal intrauterine environment; however, the underlying molecular mechanisms remain unknown. We used a well-established rat model of maternal undernutrition (MUN) during pregnancy that results in offspring intrauterine growth restriction (IUGR) and adult CLD to test the hypothesis that excess maternal glucocorticoids in response to MUN programs offspring lung development to a CLD phenotype by altering miRNA (miR)-29 expression, which is a key miR in regulating extracellular matrix (ECM) deposition during development and injury-repair...
August 8, 2018: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
Danila Morano, Stefania Rossi, Cristina Lapucci, Maria Carla Pittalis, Antonio Farina
OBJECTIVE: Our objective was to retrospectively evaluate whether the levels of cell-free DNA (cfDNA) fetal fraction differed in the first trimester of pregnancies between controls and those who subsequently developed early- or late-onset fetal growth restriction (FGR). METHODS: This was a case-control study conducted between May 2015 and May 2018 in 231 low-risk women who had received first trimester screening for major fetal aneuploidies (Panorama, Natera, San Carlos, CA, USA)...
July 28, 2018: Molecular Diagnosis & Therapy
Ebru Alici Davutoglu, Aysegul Ozel, Funda Oztunc, Riza Madazli
OBJECTIVE: To compare the fetal modified myocardial performance index (Mod-MPI) in appropriately grown, early (EO) and late onset (LO) fetal growth restricted (FGR) fetuses and to assess its prognostic significance for adverse perinatal outcome. STUDY DESIGN: In a prospective case-control study, Mod-MPI was performed in 22 and 51 fetuses with EO and LO-FGR fetuses, respectively. Mod-MPI values of FGR fetuses were compared against gestation-matched controls (34 for EO-, and 32 for LO-FGR, respectively)...
July 22, 2018: Journal of Maternal-fetal & Neonatal Medicine
Abhishek Chopra, Anup Thakur, Pankaj Garg, Neelam Kler, Kanwal Gujral
BACKGROUND: Delayed cord clamping is the standard of care in infants not requiring resuscitation; however effects of cord clamping strategies have not been evaluated systematically in small for gestational age (SGA) infants. The primary objective was to compare effects of delayed cord clamping (DCC) and early cord clamping (ECC) on serum ferritin at 3 months in SGA infants born at ≥35 weeks. The secondary objectives were to compare hematological parameters, clinical outcomes in neonatal period and growth at 3 months of age...
July 18, 2018: BMC Pediatrics
Ke-Jun Ye, Jie Dai, Ling-Yun Liu, Meng-Jia Peng
The guilt by association (GBA) principle has been widely used to predict gene functions, and a network‑based approach may enhance the confidence and stability of the analysis compared with focusing on individual genes. Fetal growth restriction (FGR), is the second primary cause of perinatal mortality. Therefore, the present study aimed to predict the optimal gene functions for FGR using a network‑based GBA method. The method was comprised of four parts: Identification of differentially‑expressed genes (DEGs) between patients with FGR and normal controls based on gene expression data; construction of a co‑expression network (CEN) dependent on DEGs, using the Spearman correlation coefficient algorithm; collection of gene ontology (GO) data on the basis of a known confirmed database and DEGs; and prediction of optimal gene functions using the GBA algorithm, for which the area under the receiver operating characteristic curve (AUC) was obtained for each GO term...
September 2018: Molecular Medicine Reports
Eimer G O'Malley, Shona Cawley, Ciara M E Reynolds, Rachel A K Kennedy, Anne Molloy, Michael J Turner
OBJECTIVES: Using detailed dietary and supplement questionnaires in early pregnancy, we compared the dietary intakes of micronutrients and macronutrients at the first prenatal visit of women who reported continuing to smoke during pregnancy with the intakes of women who were non-smokers. DESIGN: Cross-sectional study conducted between June 2014 and March 2016. SETTING: Stand-alone tertiary maternity hospital in an urban setting with approximately 8000 deliveries per year...
July 12, 2018: BMJ Open
Gang An, Yuan Lin, Liang Pu Xu, Hai Long Huang, Si Ping Liu, Yan Hong Yu, Fang Yang
Background: Application of chromosomal microarray analysis (CMA) to investigate the genetic characteristics of fetal growth restriction (FGR) without ultrasonic structural anomalies at 18-32 weeks. Methods: This study includes singleton fetuses with the estimated fetal weight (EFW) using the formula of Hadlock C below the 10th percentile for gestational age. FGRs without structural anomalies were selected, and the ones at high risk of noninvasive prenatal testing for trisomy 13, 18 and 21 would be excluded...
2018: Molecular Cytogenetics
Robert E Black, Rebecca Heidkamp
Stunting of linear growth, a highly prevalent problem in children of low- and middle-income countries, is the result of the exposure of the fetus and/or young child to nutritional deficiencies and infectious diseases. Maternal undernutrition results in fetal growth restriction, and infectious diseases in pregnancy can result in preterm delivery. Both of these conditions are important contributors to stunting in early childhood, albeit their relative contribution varies by world region. After birth, growth faltering may begin at 3-5 months of life and becomes more prominent from 6 to 18 months...
2018: Nestlé Nutrition Institute Workshop Series
B H Boehmer, L D Brown, S R Wesolowski, W W Hay, P J Rozance
Impaired β-cell development and insulin secretion are characteristic of intrauterine growth-restricted (IUGR) fetuses. In normally grown late gestation fetal sheep pancreatic β-cell numbers and insulin secretion are increased by 7-10 days of pulsatile hyperglycemia (PHG). Our objective was to determine if IUGR fetal sheep β-cell numbers and insulin secretion could also be increased by PHG or if IUGR fetal β-cells do not have the capacity to respond to PHG. Following chronic placental insufficiency producing IUGR in twin gestation pregnancies (n=7), fetuses were administered a PHG infusion, consisting of 60 min, high rate, pulsed infusions of dextrose three times a day with an additional continuous, low-rate infusion of dextrose to prevent a decrease in glucose concentrations between the pulses or a control saline infusion...
July 5, 2018: Journal of Developmental Origins of Health and Disease
Tatsuya Arakaki, Junichi Hasegawa, Masamitsu Nakamura, Hiroko Takita, Shoko Hamada, Tomohiro Oba, Ryu Matsuoka, Akihiko Sekizawa
OBJECTIVES: To clarify whether early-onset fetal growth restriction (EO-FGR) could be distinguished from late-onset (LO)-FGR using ultrasonographic evaluations of the uterine artery (UtA) Doppler indices and the three-dimensional (3D) ultrasound placental volume (PV) in the first trimester. METHODS: Subjects with 1362 singleton pregnancies who underwent an ultrasound scan at 11-13 weeks were enrolled prospectively. The UtA Doppler and PV indices in cases with EO-FGR (< 32 weeks at diagnosis) and LO-FGR (≥ 32 weeks at diagnosis) later in pregnancy were compared with the control group...
July 4, 2018: Journal of Maternal-fetal & Neonatal Medicine
Rhiannon Mellis, Natalie Chandler, Lyn S Chitty
The advent of affordable and rapid next-generation sequencing has been transformative for prenatal diagnosis. Sequencing of cell-free DNA in maternal plasma has enabled the development of not only a highly sensitive screening test for fetal aneuploidies, but now definitive noninvasive prenatal diagnosis for monogenic disorders at an early gestation. Sequencing of fetal exomes offers broad diagnostic capability for pregnancies with unexpected fetal anomalies, improving the yield and accuracy of diagnoses and allowing better counseling for parents...
July 18, 2018: Expert Review of Molecular Diagnostics
Suneeta Senapati, Fan Wang, Teri Ord, Christos Coutifaris, Rui Feng, Monica Mainigi
PURPOSE: Epidemiologic data suggest that in vitro fertilization (IVF) is associated with an increased risk of disorders of placentation including preeclampsia and fetal growth restriction. Specifically, studies have demonstrated that singleton pregnancies conceived following a fresh embryo transfer are at an increased risk of delivering an infant with low birth weight compared to those conceived following a frozen embryo transfer. The mechanism responsible for this association remains unclear...
June 29, 2018: Journal of Assisted Reproduction and Genetics
Kirsten Mense, Julia Heidekorn-Dettmer, Elisa Wirthgen, Yette Brockelmann, Ralf Bortfeldt, Sarah Peter, Markus Jung, Christine Höflich, Andreas Hoeflich, Marion Schmicke
Insulin-like growth factors (IGFs) play a critical role in fetal growth, and components of the IGF system have been associated with fetal growth restriction in women. In human pregnancy, the proteolytic cleavage of insulin-like growth factor binding proteins (IGFBPs), particularly IGFBP-4, releases free IGF for respective action at the tissue level. The aim of the present study was to determine IGFBP-2, IGFBP-3, and IGFBP-4 concentrations by Western ligand blotting during pregnancy until day 100 in cows and to compare these concentrations with those of non-pregnant cows and cows undergoing embryonic/fetal mortality...
2018: Frontiers in Endocrinology
Joëlle Lapoirie, Anne Contis, Alexandre Guy, François Lifermann, Jean-François Viallard, Loïc Sentilhes, Chloé James, Pierre Duffau
INTRODUCTION: Philadelphia-negative myeloproliferative neoplasms (MPNs) greatly increase the risk of maternal and fetal complications during pregnancy. Currently, international agreements regarding the management of these women are lacking. PATIENTS AND METHODS: Our study aimed to assess the current management and outcomes of MPN pregnancies in a French cohort. We retrospectively analyzed 27 pregnancies in women with MPNs that were associated with a specific mutation...
June 26, 2018: Journal of Maternal-fetal & Neonatal Medicine
(no author information available yet)
Low-dose aspirin has been used during pregnancy, most commonly to prevent or delay the onset of preeclampsia. The American College of Obstetricians and Gynecologists issued the Hypertension in Pregnancy Task Force Report recommending daily low-dose aspirin beginning in the late first trimester for women with a history of early-onset preeclampsia and preterm delivery at less than 34 0/7 weeks of gestation, or for women with more than one prior pregnancy complicated by preeclampsia. The U.S. Preventive Services Task Force published a similar guideline, although the list of indications for low-dose aspirin use was more expansive...
July 2018: Obstetrics and Gynecology
(no author information available yet)
Low-dose aspirin has been used during pregnancy, most commonly to prevent or delay the onset of preeclampsia. The American College of Obstetricians and Gynecologists issued the Hypertension in Pregnancy Task Force Report recommending daily low-dose aspirin beginning in the late first trimester for women with a history of early-onset preeclampsia and preterm delivery at less than 34 0/7 weeks of gestation, or for women with more than one prior pregnancy complicated by preeclampsia. The U.S. Preventive Services Task Force published a similar guideline, although the list of indications for low-dose aspirin use was more expansive...
July 2018: Obstetrics and Gynecology
Agustin Conde-Agudelo, José Villar, Stephen H Kennedy, Aris T Papageorghiou
OBJECTIVE: The cerebroplacental ratio (CPR) has been proposed for the routine surveillance of pregnancies with suspected fetal growth restriction (FGR), but the predictive performance of this test is unclear. The aim of this study was to determine the accuracy of the CPR for predicting adverse perinatal and neurodevelopmental outcomes in suspected FGR. METHODS: PubMed, EMBASE, CINAHL, and Lilacs (all from inception to July 31, 2017) were searched for cohort or cross-sectional studies that reported on the accuracy of the CPR for predicting adverse perinatal and/or neurodevelopmental outcomes in singleton pregnancies with antenatally suspected FGR based on sonographic parameters...
June 19, 2018: Ultrasound in Obstetrics & Gynecology
Judith Elisabeth Müller, Nicole Meyer, Clarisa Guillermina Santamaria, Anne Schumacher, Enrique Hugo Luque, Maria Laura Zenclussen, Horacio Adolfo Rodriguez, Ana Claudia Zenclussen
Endocrine disrupting chemicals are long suspected to impair reproductive health. Bisphenol A (BPA) has estrogenic activity and therefore the capacity of interfering with endocrine pathways. No studies dissected its short-term effects on pregnancy and possible underlying mechanisms. Here, we studied how BPA exposure around implantation affects pregnancy, particularly concentrating on placentation and uterine remodeling. We exposed pregnant female mice to 50 µg/kg BPA/day or 0.1% ethanol by oral gavage from day 1 to 7 of gestation...
June 15, 2018: Scientific Reports
M Alberry
No abstract text is available yet for this article.
June 15, 2018: BJOG: An International Journal of Obstetrics and Gynaecology
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