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Omid Savabi, Farahnaz Nejatidanesh, Kamran Poshang Bagheri, Leila Karimi, Ghazal Savabi
Background: Disinfection of dental impression is mandatory for preventing the cross infection between dental staff and dental laboratory. Ozone as a disinfectant can be used in various ways in dentistry. The aim of this study was to evaluate the efficacy of ozonated water for disinfection of irreversible hydrocolloid impression materials and preventing cross-contamination. Methods: Thirty-two circular specimens (1 cm diameter and 2 mm thickness) of irreversible hydrocolloid impression material were made...
2018: International Journal of Preventive Medicine
Siobhan Crittenden, Ashleigh Cheyne, Alexander Adams, Thorsten Forster, Calum T Robb, Jennifer Felton, Gwo-Tzer Ho, Dominik Ruckerl, Adriano G Rossi, Stephen M Anderton, Peter Ghazal, Jack Satsangi, Sarah E Howie, Chengcan Yao
Inflammatory bowel disease (IBD) is a condition of chronic inflammatory intestinal disorder with increasing prevalence but limited effective therapies. The purine metabolic pathway is involved in various inflammatory processes including IBD. However, the mechanisms through which purine metabolism modulates IBD remain to be established. Here we found that mucosal expression of genes involved in the purine metabolic pathway is altered in patients with active ulcerative colitis (UC), which is associated with elevated gene expression signatures of the group 3 innate lymphoid cell (ILC3)-interleukin (IL)-22 pathway...
May 14, 2018: Immunology and Cell Biology
Abdel Naser Zaid, Asma Radwan, Nidal Jaradat, Ayman Mousa, Nadia Ghazal, Rana Bustami
In this study, the in vitro and in vivo interchangeability between generic candesartan 16 mg and the branded formulation was assessed. The in vitro release of these products was conducted in 3 pH media (1.2, 5.0, and 6.8), and similarity factors (f2 ) were calculated. This bioequivalence study was a randomized, 2-period crossover study that included 42 healthy adult male subjects under fasting conditions with a 9-day washout. The pharmacokinetic (PK) parameters AUC0-last , AUC0-∞ , and Cmax , tmax , and the elimination half-life time were assessed based on the plasma concentrations of candesartan, using a newly developed and validated liquid chromatography-tandem mass spectrometry bioanalytical method with acceptable degrees of linearity, sensitivity, precision, and accuracy...
May 10, 2018: Clinical Pharmacology in Drug Development
Ghazal Darfarin, Roya Salehi, Effat Alizadeh, Behnam Nasiri Motlagh, Abolfazl Akbarzadeh, Alireza Farajollahi
INTRODUCTION: Recently it has been shown that radiation dose enhancement could be achievable in radiotherapy using nanoparticles (NPs). In this study, evaluation was made to determine efficiency of gold-silica shell-core NP in megavoltage irradiation of MCF7 breath cancer cells. MATERIALS AND METHODS: Gold-silicon oxide shell-core NPs were obtained by conjugation of gold NP with amine or thiol functionalized silica NPs (AuN@SiO2 and AuS@SiO2 ). Cellular uptake and cytotoxicity of NPs were examined by fluorescent microscopy and MTT assay, respectively...
May 9, 2018: Artificial Cells, Nanomedicine, and Biotechnology
Reza Abazari, Ghazal Salehi, Ali Reza Mahjoub
Using a green and simple route with ultrasound illumination under atmospheric pressure and at room temperature, the nanosized preparation of a Zn(II) metal-organic framework, [Zn(ATA)(BPD)]∞ (ATA = 2-aminoterephthalic acid), BPD = 1,4-bis(4-pyridyl)-2,3-diaza-1,3-butadiene), having nano-plate shape and 3D channel framework, was considered and the product was named as compound 1. The X-ray diffraction (XRD), scanning electron microscopy (SEM), IR spectroscopy, Brunauer-Emmett-Teller (BET), and thermogravimetric analysis (TGA) were used for characterization of the synthesized micro/nano-structures...
September 2018: Ultrasonics Sonochemistry
Javad Behravan, Atefeh Razazan, Ghazal Behravan
Breast cancer is the second leading cause of cancer death among women. National cancer institute of the US estimates that one in eight women will be diagnosed with breast cancer during their life time. Considering the devastating effects of the disease and the alarming numbers many scientists and research groups have devoted their research to fight breast cancer. Several recommendations are to be considered as preventing measures which include living a healthy life style, regular physical activity, weight control and, smoking cessation...
May 2, 2018: Current Drug Discovery Technologies
Alanna Weisman, Ghazal S Fazli, Ashley Johns, Gillian L Booth
Currently, the global prevalence of diabetes is 8.8%. This figure is expected to increase worldwide, with the largest changes projected to occur in low- and middle-income countries. The aging of the world's population and substantial increases in obesity have contributed to the rise in diabetes. Global shifts in lifestyles have led to the adoption of unhealthy behaviours such as physical inactivity and poorer-quality diets. Correspondingly, diabetes is a rapidly-increasing problem in higher- as well as lower-income countries...
May 2018: Canadian Journal of Cardiology
Nadiah Ghazalli, Xiaoxing Wu, Stephanie Walker, Nancy Trieu, Li-Yu Hsin, Justin Choe, Chialin Chen, Jasper Hsu, Jeanne LeBon, Mark T Kozlowski, Jeffrey Rawson, David A Tirrell, M L Richard Yip, Hsun Teresa Ku
Pluripotent stem cells may serve as an alternative source of beta-like cells for replacement therapy of type 1 diabetes; however, the beta-like cells generated in many differentiation protocols are immature. The maturation of endogenous beta cells involves an increase in insulin expression starting in late gestation and a gradual acquisition of the abilities to sense glucose and secrete insulin by week 2 after birth in mice; however, what molecules regulate these maturation processes are incompletely known...
May 2, 2018: Stem Cells and Development
Imane Allali, Noureddine Boukhatem, Leila Bouguenouch, Hanaa Hardi, H Abir Boudouaya, M Belen Cadenas, Karim Ouldim, Saaïd Amzazi, M Andrea Azcarate-Peril, Hassan Ghazal
Although colorectal cancer is the third leading cause of death in Morocco, there are no studies of the microbiome changes associated with the disease in the Moroccan population. The aim of our study was to compare the stool microbiome of Moroccan cancer patients with healthy individuals. We analyzed the microbiome composition of samples from 11 CRC patients and 12 healthy individuals by 16S rRNA amplicon sequencing. Principal coordinate analysis of samples revealed defined cancer versus healthy clusters. Our findings showed that cancer samples had higher proportions of Firmicutes (T = 50...
April 23, 2018: Medical Microbiology and Immunology
Seong H Choi, Ghazal Gharahmany, Rosemary L Walzem, Thomas H Meade, Stephen B Smith
We hypothesized that consumption of saturated fatty acids in the form of high-fat ground beef for 5 weeks would depress liver X receptor signaling targets in peripheral blood mononuclear cells (PBMC) and that changes in gene expression would be associated with the corresponding changes in lipoprotein cholesterol (C) concentrations. Older men (n = 5, age 68.0 ± 4.6 years) and postmenopausal women (n = 7, age 60.9 ± 3.1 years) were assigned randomly to consume ground-beef containing 18% total fat (18F) or 25% total fat (25F), five patties per week for 5 weeks with an intervening 4-week washout period...
March 2018: Lipids
Farahnaz Nejatidanesh, Omid Savabi, Ghazal Savabi, Mehdi Razavi
OBJECTIVE: The aim of this study was to evaluate the effect of different cleaning regimens on retentive strength of saliva-contaminated implant-supported zirconia copings. MATERIAL AND METHODS: Seventy solid titanium abutments with 5.5 mm height (Straumann) were attached to the regular neck implant analogs (Straumann). The abutment-analog complex was mounted vertically in an autopolymerized T-shaped acrylic resin block. Seventy zirconia copings with an occlusal loop were made...
April 15, 2018: Clinical Oral Implants Research
Ghazal Shafai-Erfani, Twyla Willoughby, Naren Ramakrishna, Sanford Meeks, Patrick Kelly, Omar Zeidan
PURPOSE: The purpose of this study was to investigate daily repositioning accuracy by analyzing inter- and intra-fractional uncertainties associated with patients treated for intracranial or base of skull tumors in a compact proton therapy system with 6 degrees of freedom (DOF) robotic couch and a thermoplastic head mask indexed to a base of skull (BoS) frame. MATERIALS AND METHODS: Daily orthogonal kV alignment images at setup position before and after daily treatments were analyzed for 33 patients...
April 6, 2018: Journal of Applied Clinical Medical Physics
Mariam Sabbar, Claire Delaville, Philippe De Deurwaerdère, Nouria Lakhdar-Ghazal, Abdelhamid Benazzouz
Background: Lead neurotoxicity is a major health problem known as a risk factor for neurodegenerative diseases, including the manifestation of parkinsonism-like disorder. While lead is known to preferentially accumulate in basal ganglia, the mechanisms underlying behavioral disorders remain unknown. Here, we investigated the neurophysiological and biochemical correlates of motor deficits induced by sub-chronic injections of lead. Methods: Sprague Dawely rats were exposed to sub-chronic injections of lead (10 mg/kg, i...
2018: Frontiers in Neuroscience
Sepehr Moalej, Shahrbanoo Kazemi, Mahsa Asadabadi, Leila Khedmat, Rezvan Hashemi, Reza Tavacolizadeh, Zahra Vahabi, Ghazal Shariatpanahi
BACKGROUND: Scoliosis is abnormal sideways curve of spine .Screening for scoliosis is controversial, and there has been significant heterogeneity between studies. In Iran, there is still no suitable device to screen sideways curves in spine. OBJECTIVE: To investigate the simple scolioscreen software for screening the students of elementary schools for detecting schoolchildren scoliosis. This students has been examined by trained medical student and data entered in scolioscreen application of Iphone...
March 16, 2018: Journal of Back and Musculoskeletal Rehabilitation
Ghazale Gholami, Kelong Zhu, Giorgio Baggi, Eduardo Schott, Ximena Zarate, Stephen J Loeb
A series of [2]rotaxane molecular shuttles was prepared containing a dibenzo[24]crown-8 ( DB24C8 ) wheel and a rigid H-shaped axle with varying track lengths between recognition sites; from 7.4 to 20.3 Å as defined by 1-4 phenyl rings or a naphthyl group. The rate of shuttling was measured by variable temperature1 H NMR spectroscopy for neutral compounds and EXSY experiments for dicationic species. The rates were found to be independent of the length of the axle, except when the distance between the two recognition sites might be short enough ( n = 1) to allow the crown ether to simultaneously interact with both recognition sites providing a short-cut mechanism which could lower the energy barrier...
November 1, 2017: Chemical Science
Kristin A Williams, Sara Mithani, Ghazal Sadeghi, Leena Palomo
BACKGROUND: This randomized, single-blinded, controlled study compares the effectiveness of two modes of delivering the same set of oral hygiene instructions: those loaded on a computer-assisted teaching format versus those given personally by a self-care instructor. METHODS: 60 participants with mild to moderate periodontitis were randomized to either the computer-teaching format or the self-care instructor. Plaque score and bleeding indices were assessed at baseline and at 4 week re-evaluation to compare the instructional modalities...
January 10, 2018: Dentistry journal
Mohamed Ahmed Abdel-Mohsen, Ahlam Abd-Allah El-Braky, Abeer Abd El-Rahim Ghazal, Mohammed Mohammed Shamseya
The aims of this study were to investigate the interplay between autophagy and apoptosis and to investigate the association between both of autophagy and apoptosis and vitamin D and its receptor in hepatitis C virus (HCV) viral infection and its implication in the progression into hepatocellular carcinoma (HCC).A cross-sectional study where serum levels of microtubule-associated protein 1A/1B-light chain 3 (LC3); marker of autophagy, caspase-3; marker of apoptosis, vitamin D3 and vitamin D receptor (VDR) were measured in healthy subjects as well as HCV and HCV-HCC patients using enzyme-linked immunosorbent assay technique...
March 2018: Medicine (Baltimore)
Philipp Al Ghazal, Lisa-Lena Grönemeyer, Michael P Schön
Als Lipomatosen bezeichnet man gutartige, meist ohne eindeutige Auslöser auftretende Vermehrungen des Fettgewebes, oft mit typischem Verteilungsmuster. Im Gegensatz zu umschriebenen Lipomen entwickeln sie sich meist diffus-symmetrisch und sind nicht von einer fibrösen Pseudokapsel umgeben. Am häufigsten ist die benigne symmetrische Lipomatose (BSL; Launois-Bensaude-Syndrom), von der aufgrund des Verteilungsmusters des hyperplastischen Fettgewebes vier Typen unterschieden werden. Ätiologie und Pathogenese der Erkrankung sind noch weitgehend unbekannt, wobei manche Formen eine hereditäre Basis zu haben oder mit vermehrtem Alkoholkonsum assoziiert zu sein scheinen...
March 2018: Journal der Deutschen Dermatologischen Gesellschaft, Journal of the German Society of Dermatology: JDDG
Peter H Khalil, Ghazal Kabbach, Debabrata Mukherjee, Sarmad Said
Heart Failure (HF) is one of the main health care burdens in the United States and in the world. Many drugs are approved and used in practice for management of this condition; including beta blockers, diuretics, aldosterone antagonists, angiotensin converting enzyme inhibitors (ACEI's), and angiotensin receptor blockers (ARBs). Recently, the Food and Drug Administration (FDA) approved a drug with brand name Entresto (Sacubitril/Valsartan or LCZ696), an angiotensin receptor neprilysin inhibitor for the use in Heart Failure with Reduced Ejection Fraction (HFrEF) patients instead of ACEI's and ARBs...
March 13, 2018: Cardiovascular & Hematological Agents in Medicinal Chemistry
Anthony W Waddle, Marlai Sai, Joshua E Levy, Ghazal Rezaei, Frank van Breukelen, Jef R Jaeger
We developed a protocol for isolating the amphibian chytrid fungus Batrachochytrium dendrobatidis (Bd) from anurans. We sampled skin tissues from 2 common treefrogs, Pseudacris regilla and P. triseriata, collected from populations with high infection prevalence. We sampled tissues from 3 anatomical ventral regions (thigh, abdomen, and foot) where the pathogen is thought to concentrate. To mitigate potential bacterial contamination, we used a unique combination of 4 antibiotics. We quantified infections on frogs as zoospore equivalents (ZE) using a swabbing approach combined with quantitative real-time polymerase chain reaction...
March 5, 2018: Diseases of Aquatic Organisms
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