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https://www.readbyqxmd.com/read/28232830/evolutionary-origin-of-the-interferon-immune-metabolic-axis-%C3%A2-the-sterol-vitamin-d-link
#1
Harry Newmark, Widad Dantoft, Peter Ghazal
In vertebrate animals, the sterol metabolic network is emerging as a central player in immunity and inflammation. Upon infection, flux in the network is acutely moderated by the interferon (IFN) response through direct molecular and bi-directional communications. How sterol metabolism became linked to IFN control and for what purpose is not obvious. Here, we deliberate on the origins of these connections based on a systematic review of the literature. A narrative synthesis of publications that met eligibility criteria allowed us to trace an evolutionary path and functional connections between cholesterol metabolism and immunity...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28217652/is-there-any-correlation-between-magnetic-resonance-imaging-features-of-breast-lesions-of-birads-category-4-with-histopathologic-results
#2
Maryam Farghadani, Ghazale Jamalipoor Soofi, Amir Hossein Sarrami
BACKGROUND: To evaluate the correlation of magnetic resonance imaging (MRI) features of breast lesions of Breast Imaging Reporting and Database System (BI-RADS) category 4 with histopathologic results. MATERIALS AND METHODS: In a prospective study between December 2013 and April 2015, patients with suspicious mammographic and/or ultrasound findings referred for Breast MRI were evaluated. Patients with lesions of BI-RADS category 4 were enrolled with a written informed consent...
2017: Advanced Biomedical Research
https://www.readbyqxmd.com/read/28211101/dental-status-as-a-predictor-of-mortality-among-nursing-facility-residents-in-eastern-iowa
#3
Daniel J Caplan, Tariq S Ghazal, Howard J Cowen, Deise C Oliveira
OBJECTIVE: This study aimed to evaluate dental status (ie, number of teeth and presence of removable dental prostheses) as a predictor of all-cause mortality among nursing facility residents. BACKGROUND: Edentulism has been associated with poorer health outcomes in geriatric populations. MATERIALS AND METHODS: Between March 2006 and June 2008, oral health screening examinations were completed for 584 residents of 10 nursing facilities in four eastern Iowa counties...
February 16, 2017: Gerodontology
https://www.readbyqxmd.com/read/28205471/a-rare-case-of-primary-tuberculous-tenosynovitis-in-a-young-patient-with-an-acute-history
#4
Alistair J M Reed, Jeremy N Rodrigues, Sharif Al-Ghazal, Zakir Shariff
We present a rare case of primary tuberculous tenosynovitis in a young patient with an acute history of non-penetrating traumatic injury. The patient had recently visited Pakistan and presented with sudden onset pain at the base of their right fifth digit after trying to catch a cricket ball. A provisional diagnosis of haematoma was made; however, ultrasonography revealed a mass attached to the A2 pulley. Surgical excision followed by histological examination and culture identified Mycobacterium Tuberculosis infection...
March 2017: Journal of Hand Surgery Asian-Pacific Volume
https://www.readbyqxmd.com/read/28195829/methylmercury-exposure-in-women-of-childbearing-age-and-children
#5
Smj Mortazavi, Ghazal Mortazavi, Maryam Paknahad
No abstract text is available yet for this article.
February 2017: Workplace Health & Safety
https://www.readbyqxmd.com/read/28170008/metal-organic-frameworks-utilising-an-interlocked-hexadentate-linker-containing-a-tetra-carboxylate-axle-and-a-bis-pyridine-wheel
#6
Ghazale Gholami, Giorgio Baggi, Kelong Zhu, Stephen J Loeb
A [2]rotaxane linker was synthesized which combines an H-shaped axle containing four 3-carboxyphenyl groups and a macrocyclic wheel with two 4-pyridyl groups. Metal-organic framework materials were prepared with Cu(II) and Zn(II) ions X-ray structures show that the materials contain unique frameworks that are threaded solely due to the interpenetrated nature of the linker.
February 7, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/28162005/the-clinical-significance-of-complete-class-switching-defect-in-ataxia-telangiectasia-patients
#7
Saleh Ghiasy, Leila Parvaneh, Gholamreza Azizi, Ghazal Sadri, Majid Zaki Dizaji, Hassan Abolhassani, Asghar Aghamohammadi
OBJECTIVES: Ataxia telangiectasia (AT) is a primary immunodeficiency associated with recurrent infections. We aimed to investigate clinical and immunological classification in AT patients who suffer from a different spectrum of humoral immune defects. METHODS: AT patients were categorized according to the ability of class switching and patients with hyper IgM (HIgM) profile were defined as class switching defect (CSD). RESULTS: Serum immunoglobulin profile in 66 AT patients showed normal immunoglobulin level (22...
February 4, 2017: Expert Review of Clinical Immunology
https://www.readbyqxmd.com/read/28129677/monogenic-auto-in%C3%AF-ammatory-syndromes-a-review-of-the-literature
#8
Gholamreza Azizi, Shahin Khadem Azarian, Sepideh Nazeri, Ali Mosayebian, Saleh Ghiasy, Ghazal Sadri, Ali Mohebi, Nikoo Hossein Khan Nazer, Sanaz Afraei, Abbas Mirshafiey
Auto-inflammatory syndromes are a new group of distinct hereditable disorders characterized by episodes of seemingly unprovoked inflammation (most commonly in skin, joints, gut, and eye), the absence of a high titer of auto-antibodies or auto-reactive T cells, and an inborn error of innate immunity. A narrative literature review was carried out of studies related to auto-inflammatory syndromes to discuss the pathogenesis and clinical manifestation of these syndromes. This review showed that the main monogenic auto-inflammatory syndromes are familial Mediterranean fever (FMF), mevalonate kinase deficiency (MKD), Blau syndrome, TNF receptor-associated periodic syndrome (TRAPS), cryopyrin-associated periodic syndrome (CAPS), and pyogenic arthritis with pyoderma gangrenosum and acne (PAPA)...
December 2016: Iranian Journal of Allergy, Asthma, and Immunology
https://www.readbyqxmd.com/read/28117319/investigation-of-the-bioequivalence-of-rosuvastatin-20-mg-tablets-after-a-single-oral-administration-in-mediterranean-arabs-using-a-validated-lc-ms-ms-method
#9
Abdel Naser Zaid, Rowa Al Ramahi, Rita Cortesi, Ayman Mousa, Nidal Jaradat, Nadia Ghazal, Rana Bustami
There is a wide inter-individual response to statin therapy including rosuvastatin calcium (RC), and it has been hypothesized that genetic differences may contribute to these variations. In fact, several studies have shown that pharmacokinetic (PK) parameters for RC are affected by race. The aim of this study is to demonstrate the interchangeability between two generic RC 20 mg film-coated tablets under fasting conditions among Mediterranean Arabs and to compare the pharmacokinetic results with Asian and Caucasian subjects from other studies...
June 30, 2016: Scientia Pharmaceutica
https://www.readbyqxmd.com/read/28113953/towards-high-throughput-cell-growth-screening-a-new-cmos-8-%C3%A3-8-biosensor-array-for-life-science-applications
#10
Ghazal Nabovati, Ebrahim Ghafar-Zadeh, Antoine Letourneau, Mohamad Sawan
In this paper we present a CMOS capacitive sensor array as a compact and low-cost platform for high-throughput cell growth monitoring. The proposed biosensor, consists of an array of 8 × 8 CMOS fully differential charge-based capacitive measurement sensors. A DC-input Σ∆ modulator is used to convert the sensors' signals to digital values for reading out the biological/chemical data and further signal processing. To compensate the mismatch variations between the current mirror transistors, a calibration circuitry is proposed which removes the output voltage offset with less than 8...
November 14, 2016: IEEE Transactions on Biomedical Circuits and Systems
https://www.readbyqxmd.com/read/28097164/molecular-characterization-and-construction-of-an-infectious-clone-of-a-pepper-isolate-of-beet-curly-top-iran-virus
#11
Omid Eini, Ghazal Ebadzad Sahraei, Seyed Ali Akbar Behjatnia
Geminiviruses cause curly top disease, in dicotyledonous plants which constrains host crop production. Beet curly top Iran virus (BCTIV) is a widespread Becurtovirus (family Geminiviridae) in numerous areas within Iran. In this study, we isolated and analyzed a full-length genomic DNA of a new variant of BCTIV from pepper crops in the Kaftark region, east of Shiraz (proposed acronym: BCTIV-Kaf [IR: Kaf:2016:Pepper]). Infected pepper plants showed shortening of internodes, severe interveinal chlorosis, upward leaf rolling and leaf curling...
June 2016: Molecular Biology Research Communications
https://www.readbyqxmd.com/read/28049454/identifying-mechanisms-for-facilitating-knowledge-to-action-strategies-targeting-the-built-environment
#12
Ghazal S Fazli, Maria I Creatore, Flora I Matheson, Sara Guilcher, Vered Kaufman-Shriqui, Heather Manson, Ashley Johns, Gillian L Booth
BACKGROUND: In recent years, obesity-related diseases have been on the rise globally resulting in major challenges for health systems and society as a whole. Emerging research in population health suggests that interventions targeting the built environment may help reduce the burden of obesity and type 2 diabetes. However, translation of the evidence on the built environment into effective policy and planning changes requires engagement and collaboration between multiple sectors and government agencies for designing neighborhoods that are more conducive to healthy and active living...
January 3, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28043902/stem-cells-and-combination-therapy-for-the-treatment-of-traumatic-brain-injury
#13
AmiraSan Dekmak, Sarah Mantash, Abdullah Shaito, Amer Toutonji, Naify Ramadan, Hussein Ghazale, Nouhad Kassem, Hala Darwish, Kazem Zibara
TBI is a nondegenerative, noncongenital insult to the brain from an external mechanical force; for instance a violent blow in a car accident. It is a complex injury with a broad spectrum of symptoms and has become a major cause of death and disability in addition to being a burden on public health and societies worldwide. As such, finding a therapy for TBI has become a major health concern for many countries, which has led to the emergence of many monotherapies that have shown promising effects in animal models of TBI, but have not yet proven any significant efficacy in clinical trials...
December 30, 2016: Behavioural Brain Research
https://www.readbyqxmd.com/read/28028774/embryo-wastage-rates-remain-high-in-assisted-reproductive-technology-art-a-look-at-the-trends-from-2004-2013-in-the-usa
#14
Sanaz Ghazal, Pasquale Patrizio
This work examined the trend in "embryo wastage" rates after ART in USA and its relationship to the number of embryos transferred, live born infants delivered across patient age, and the yearly percentage of embryos wasted. The data were obtained from the US-clinics SART databank for the years 2004-2013. A total of 1,808,082 non-donor embryos were transferred in 748,394 fresh cycles resulting in 358,214 liveborn. During the years of analysis, the mean number of embryos transferred has progressively decreased leading to an overall significant decrease in Embryo Wastage rates (83...
December 27, 2016: Journal of Assisted Reproduction and Genetics
https://www.readbyqxmd.com/read/27999460/minimally-displaced-distal-radius-fracture-treated-with-closed-reduction-and-percutaneous-fixation-resulting-in-an-iatrogenic-galeazzi-lesion
#15
Luce Compagnone, Rakan Ghazal, Federico Canavese
Galeazzi fracture in skeletally immature patients is a relatively uncommon injury. No previously published case has been associated with an iatrogenic mechanism. Here, we report a case of a 10-year-old boy with a minimally displaced distal radius fracture evolving into a Galeazzi lesion after unnecessary surgical treatment. Unnecessary surgical procedure associated with poor knowledge of bone growth and physiology contributed significantly to the reported condition.
December 2016: Journal of Hand and Microsurgery
https://www.readbyqxmd.com/read/27976729/interactomic-analysis-of-rest-nrsf-and-implications-of-its-functional-links-with-the-transcription-suppressor-trim28-during-neuronal-differentiation
#16
Namgyu Lee, Sung Jin Park, Ghazal Haddad, Dae-Kyum Kim, Seon-Min Park, Sang Ki Park, Kwan Yong Choi
RE-1 silencing transcription factor (REST) is a transcriptional repressor that regulates gene expression by binding to repressor element 1. However, despite its critical function in physiology, little is known about its interaction proteins. Here we identified 204 REST-interacting proteins using affinity purification and mass spectrometry. The interactome included proteins associated with mRNA processing/splicing, chromatin organization, and transcription. The interactions of these REST-interacting proteins, which included TRIM28, were confirmed by co-immunoprecipitation and immunocytochemistry, respectively...
December 15, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27936765/microfluidic-platform-for-the-continuous-production-and-characterization-of-multilamellar-vesicles-a-synchrotron-small-angle-x-ray-scattering-saxs-study
#17
Aghiad Ghazal, Mark Gontsarik, Jörg P Kutter, Josiane P Lafleur, Davoud Ahmadvand, Ana Labrador, Stefan Salentinig, Anan Yaghmur
A microfluidic platform combined with synchrotron small-angle X-ray scattering (SAXS) was used for monitoring the continuous production of multilamellar vesicles (MLVs). Their production was fast and started to evolve within less than 0.43 s of contact between the lipids and the aqueous phase. To obtain nanoparticles with a narrow size distribution, it was important to use a modified hydrodynamic flow focusing (HFF) microfluidic device with narrower microchannels than those normally used for SAXS experiments...
December 12, 2016: Journal of Physical Chemistry Letters
https://www.readbyqxmd.com/read/27926930/cytomegalovirus-specific-il-10-producing-cd4-t-cells-are-governed-by-type-i-ifn-induced-il-27-and-promote-virus-persistence
#18
Mathew Clement, Morgan Marsden, Maria A Stacey, Juneid Abdul-Karim, Silvia Gimeno Brias, Diana Costa Bento, Martin J Scurr, Peter Ghazal, Casey T Weaver, Gianluca Carlesso, Simon Clare, Simon A Jones, Andrew Godkin, Gareth W Jones, Ian R Humphreys
CD4+ T cells support host defence against herpesviruses and other viral pathogens. We identified that CD4+ T cells from systemic and mucosal tissues of hosts infected with the β-herpesviridae human cytomegalovirus (HCMV) or murine cytomegalovirus (MCMV) express the regulatory cytokine interleukin (IL)-10. IL-10+CD4+ T cells co-expressed TH1-associated transcription factors and chemokine receptors. Mice lacking T cell-derived IL-10 elicited enhanced antiviral T cell responses and restricted MCMV persistence in salivary glands and secretion in saliva...
December 2016: PLoS Pathogens
https://www.readbyqxmd.com/read/27904492/hydroxycitric-acid-ameliorates-inflammation-and-oxidative-stress-in-mouse-models-of-multiple-sclerosis
#19
Mahdi Goudarzvand, Sanaz Afraei, Somaye Yaslianifard, Saleh Ghiasy, Ghazal Sadri, Mustafa Kalvandi, Tina Alinia, Ali Mohebbi, Reza Yazdani, Shahin Khadem Azarian, Abbas Mirshafiey, Gholamreza Azizi
Hydroxycitric acid (HCA) is derived primarily from the Garcinia plant and is widely used for its anti-inflammatory effects. Multiple sclerosis can cause an inflammatory demyelination and axonal damage. In this study, to validate the hypothesis that HCA exhibits therapeutic effects on multiple sclerosis, we established female C57BL/6 mouse models of multiple sclerosis, i.e., experimental autoimmune encephalomyelitis, using Complete Freund's Adjuvant (CFA) emulsion containing myelin oligodendrocyte glycoprotein (35-55)...
October 2016: Neural Regeneration Research
https://www.readbyqxmd.com/read/27895858/distribution-of-pathogenicity-island-pai-markers-and-phylogenetic-groups-in-diarrheagenic-and-commensal-escherichia-coli-from-young-children
#20
Ghazal Naderi, Fakhri Haghi, Habib Zeighami, Fatemeh Hemati, Neda Masoumian
AIM: This case-control study investigated the various PAI markers, phylogenetic groups and antimicrobial susceptibility among DEC and commensal E. coli isolates. BACKGROUND: Diarrheagenic Escherichia coli (DEC) is an emerging agent among pathogens that cause diarrheal diseases and represents a major public health problem in developing countries. The major difference in virulence among DEC pathotype and commensals may be related to the presence of specific genomic segments, termed pathogenicity islands (PAIs)...
2016: Gastroenterology and Hepatology From Bed to Bench
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