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https://www.readbyqxmd.com/read/28801898/secreted-reporters-for-monitoring-multiple-promoter-function
#1
Ghazal Lashgari, Rami S Kantar, Bakhos A Tannous
Secreted reporter proteins are reliable modalities for monitoring of different biological processes, which can be measured longitudinally in conditioned medium of cultured cells or body fluids such as blood and urine, ex vivo. In this chapter, we will explore established secreted reporters and their applications and limitations for monitoring of promoter function. We will also describe both cell-based and blood-based assays for detecting three commonly used reporters: secreted alkaline phosphatase (SEAP ), Gaussia luciferase (Gluc), and Vargula luciferase (Vluc)...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28797005/gamma-knife-radiosurgery-for-cavernous-sinus-meningiomas-analysis-of-outcome-in-166-patients
#2
Maziar Azar, Farid Kazemi, Amin Jahanbakhshi, Iran Chanideh, Maryam Jalessi, Elahe Amini, Ghazale Geraily, Mohammad Farhadi
OBJECTIVES: The outcomes of Gamma Knife radiosurgery (GKRS) for cavernous sinus meningioma (CSM) are presented, and factors possibly affecting outcome are investigated. METHODS: The medical records and imaging and procedural reports of 166 patients with CSM were retrospectively reviewed. Demographic data, procedural data, symptomatic improvement, radiological regression, and progression-free survival (PFS) rates were evaluated. RESULTS: There were 124 women and 42 men; including 44 postoperative and 122 primary GKRS cases...
August 11, 2017: Stereotactic and Functional Neurosurgery
https://www.readbyqxmd.com/read/28751286/troponin-elevation-in-other-conditions-than-acute-coronary-syndromes
#3
Wafa Masri, Edouard Le Guillou, Eya Hamdi, Khaldoun Ghazal, Elise Lebigot, Claudine Cosson, Françoise Blonde Cynober, Patrice Therond
Troponin is a specific cardiac infarction isoform (TnIc, TnTc) and its determination is used for the diagnosis of myocardial infarction even with normal Electrocardiography. The increase of cardiac troponins occurs in a variety of clinical situations without an acute coronary syndrome (ACS), cardiologists and emergency physicians are often confronted with positive troponins that are difficult to interpret. Few data exist about the occurrence, the clinical characteristics and the predictive value in case of absence of ACS...
August 1, 2017: Annales de Biologie Clinique
https://www.readbyqxmd.com/read/28718934/nad-a-key-metabolic-regulator-with-great-therapeutic-potential
#4
REVIEW
Ghazal Sultani, Azrah F Samsudeen, Brenna Osborne, Nigel Turner
Nicotinamide adenine dinucleotide (NAD(+) ) is a ubiquitous metabolite that serves an essential role in the catabolism of nutrients. Recently there has been a surge of interest in NAD(+) biology, with the recognition that NAD(+) influences many biological processes beyond metabolism, including transcription, signalling and cell survival. There are a multitude of pathways involved in the synthesis and breakdown of NAD(+) , and alterations in NAD(+) homeostasis have emerged as a common feature of a range of disease states...
July 18, 2017: Journal of Neuroendocrinology
https://www.readbyqxmd.com/read/28715944/comparison-of-two-different-techniques-used-for-the-maintenance-ofperi-implant-soft-tissue-health-a-pilot-randomized-clinical-trial
#5
Logien Al Ghazal, Jeffery O'Sullivan, Noel Claffey, Ioannis Polyzois
OBJECTIVES: The aim of this pilot study was to compare the effectiveness of two different methods of debridement on maintaining and improving peri-implant soft tissue health over a period of 12 months. MATERIALS AND METHODS: Twenty adult patients (25 implants) were enrolled in a randomized, single-blinded, parallel group clinical trial. All implants included showed no signs of pathologic bone loss. Patients were scheduled to be reviewed every 3 months over a 12 months period...
July 17, 2017: Acta Odontologica Scandinavica
https://www.readbyqxmd.com/read/28701090/-transference-focused-psychotherapy-for-borderline-adolescents-in-a-day-clinic-treatment-program
#6
Maya Krischer, Tamara Ponton-Rodriguez, Ghazal Rostami Gooran, Stephan Bender
Transference Focused Psychotherapy for Borderline-Adolescents in a Day Clinic Treatment Program This paper focuses on the concept of transference focused psychotherapy (TFP) modified for juvenile borderline patients. Adolescents with borderline developmental personality disorder (bpd) have an essential deficit in their personality structure that leads to oscillations in their self-esteem and in a "split" perception of the world. They suffer from a variety of symptoms and severe impairments on their own and their families' quality of life...
July 2017: Praxis der Kinderpsychologie und Kinderpsychiatrie
https://www.readbyqxmd.com/read/28698378/haploid-selection-within-a-single-ejaculate-increases-offspring-fitness
#7
Ghazal Alavioon, Cosima Hotzy, Khriezhanuo Nakhro, Sandra Rudolf, Douglas G Scofield, Susanne Zajitschek, Alexei A Maklakov, Simone Immler
An inescapable consequence of sex in eukaryotes is the evolution of a biphasic life cycle with alternating diploid and haploid phases. The occurrence of selection during the haploid phase can have far-reaching consequences for fundamental evolutionary processes including the rate of adaptation, the extent of inbreeding depression, and the load of deleterious mutations, as well as for applied research into fertilization technology. Although haploid selection is well established in plants, current dogma assumes that in animals, intact fertile sperm within a single ejaculate are equivalent at siring viable offspring...
July 25, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28684671/comment-on-giuseppe-genchi-et-al-mercury-exposure-and-heart-diseases-int-j-environ-res-public-health-2017-14-74
#8
S M J Mortazavi, Ghazal Mortazavi, Maryam Paknahad
Cenchi et al. [1] have recently published an article entitled "Mercury Exposure and Heart Diseases" that is published in Int. J. Environ. Res. Public Health 2017, 14, 74; doi:10.3390/ijerph14010074.[...].
July 6, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28667166/abnormal-movements-induced-by-methanol-toxicity
#9
Mohammad Rohani, Renato P Munhoz, Ghazal Haeri
No abstract text is available yet for this article.
June 30, 2017: Postgraduate Medical Journal
https://www.readbyqxmd.com/read/28667019/retrotransposons-are-the-major-contributors-to-the-expansion-of-the-drosophila-ananassae-muller-f-element
#10
Wilson Leung, Christopher D Shaffer, Elizabeth J Chen, Thomas J Quisenberry, Kevin Ko, John M Braverman, Thomas C Giarla, Nathan T Mortimer, Laura K Reed, Sheryl T Smith, Srebrenka Robic, Shannon R McCartha, Danielle R Perry, Lindsay M Prescod, Zenyth A Sheppard, Ken J Saville, Allison McClish, Emily A Morlock, Victoria R Sochor, Brittney Stanton, Isaac C Veysey-White, Dennis Revie, Luis A Jimenez, Jennifer J Palomino, Melissa D Patao, Shane M Patao, Edward T Himelblau, Jaclyn D Campbell, Alexandra L Hertz, Maddison F McEvilly, Allison R Wagner, James Youngblom, Baljit Bedi, Jeffery Bettincourt, Erin Duso, Maiye Her, William Hilton, Samantha House, Masud Karimi, Kevin Kumimoto, Rebekah Lee, Darryl Lopez, George Odisho, Ricky Prasad, Holly Lyn Robbins, Tanveer Sandhu, Tracy Selfridge, Kara Tsukashima, Hani Yosif, Nighat P Kokan, Latia Britt, Alycia Zoellner, Eric P Spana, Ben T Chlebina, Insun Chong, Harrison Friedman, Danny A Mammo, Chun L Ng, Vinayak S Nikam, Nicholas U Schwartz, Thomas Q Xu, Martin G Burg, Spencer M Batten, Lindsay M Corbeill, Erica Enoch, Jesse J Ensign, Mary E Franks, Breanna Haiker, Judith A Ingles, Lyndsay D Kirkland, Joshua M Lorenz-Guertin, Jordan Matthews, Cody M Mittig, Nicholaus Monsma, Katherine J Olson, Guillermo Perez-Aragon, Alen Ramic, Jordan R Ramirez, Christopher Scheiber, Patrick A Schneider, Devon E Schultz, Matthew Simon, Eric Spencer, Adam C Wernette, Maxine E Wykle, Elizabeth Zavala-Arellano, Mitchell J McDonald, Kristine Ostby, Peter Wendland, Justin R DiAngelo, Alexis M Ceasrine, Amanda H Cox, James E B Docherty, Robert M Gingras, Stephanie M Grieb, Michael J Pavia, Casey L Personius, Grzegorz L Polak, Dale L Beach, Heaven L Cerritos, Edward A Horansky, Karim A Sharif, Ryan Moran, Susan Parrish, Kirsten Bickford, Jennifer Bland, Juliana Broussard, Kerry Campbell, Katelynn E Deibel, Richard Forka, Monika C Lemke, Marlee B Nelson, Catherine O'Keeffe, S Mariel Ramey, Luke Schmidt, Paola Villegas, Christopher J Jones, Stephanie L Christ, Sami Mamari, Adam S Rinaldi, Ghazal Stity, Amy T Hark, Mark Scheuerman, Cathy Silver Key, Briana D McRae, Adam S Haberman, Sam Asinof, Harriette Carrington, Kelly Drumm, Terrance Embry, Richard McGuire, Drew Miller-Foreman, Stella Rosen, Nadia Safa, Darrin Schultz, Matt Segal, Yakov Shevin, Petros Svoronos, Tam Vuong, Gary Skuse, Don W Paetkau, Rachael K Bridgman, Charlotte M Brown, Alicia R Carroll, Francesca M Gifford, Julie Beth Gillespie, Susan E Herman, Krystal L Holtcamp, Misha A Host, Gabrielle Hussey, Danielle M Kramer, Joan Q Lawrence, Madeline M Martin, Ellen N Niemiec, Ashleigh P O'Reilly, Olivia A Pahl, Guadalupe Quintana, Elizabeth A S Rettie, Torie L Richardson, Arianne E Rodriguez, Mona O Rodriguez, Laura Schiraldi, Joanna J Smith, Kelsey F Sugrue, Lindsey J Suriano, Kaitlyn E Takach, Arielle M Vasquez, Ximena Velez, Elizabeth J Villafuerte, Laura T Vives, Victoria R Zellmer, Jeanette Hauke, Charles R Hauser, Karolyn Barker, Laurie Cannon, Perouza Parsamian, Samantha Parsons, Zachariah Wichman, Christopher W Bazinet, Diana E Johnson, Abubakarr Bangura, Jordan A Black, Victoria Chevee, Sarah A Einsteen, Sarah K Hilton, Max Kollmer, Rahul Nadendla, Joyce Stamm, Antoinette E Fafara-Thompson, Amber M Gygi, Emmy E Ogawa, Matt Van Camp, Zuzana Kocsisova, Judith L Leatherman, Cassie M Modahl, Michael R Rubin, Susana S Apiz-Saab, Suzette M Arias-Mejias, Carlos F Carrion-Ortiz, Patricia N Claudio-Vazquez, Debbie M Espada-Green, Marium Feliciano-Camacho, Karina M Gonzalez-Bonilla, Mariela Taboas-Arroyo, Dorianmarie Vargas-Franco, Raquel Montañez-Gonzalez, Joseph Perez-Otero, Myrielis Rivera-Burgos, Francisco J Rivera-Rosario, Heather L Eisler, Jackie Alexander, Samatha K Begley, Deana Gabbard, Robert J Allen, Wint Yan Aung, William D Barshop, Amanda Boozalis, Vanessa P Chu, Jeremy S Davis, Ryan N Duggal, Robert Franklin, Katherine Gavinski, Heran Gebreyesus, Henry Z Gong, Rachel A Greenstein, Averill D Guo, Casey Hanson, Kaitlin E Homa, Simon C Hsu, Yi Huang, Lucy Huo, Sarah Jacobs, Sasha Jia, Kyle L Jung, Sarah Wai-Chee Kong, Matthew R Kroll, Brandon M Lee, Paul F Lee, Kevin M Levine, Amy S Li, Chengyu Liu, Max Mian Liu, Adam P Lousararian, Peter B Lowery, Allyson P Mallya, Joseph E Marcus, Patrick C Ng, Hien P Nguyen, Ruchik Patel, Hashini Precht, Suchita Rastogi, Jonathan M Sarezky, Adam Schefkind, Michael B Schultz, Delia Shen, Tara Skorupa, Nicholas C Spies, Gabriel Stancu, Hiu Man Vivian Tsang, Alice L Turski, Rohit Venkat, Leah E Waldman, Kaidi Wang, Tracy Wang, Jeffrey W Wei, Dennis Y Wu, David D Xiong, Jack Yu, Karen Zhou, Gerard P McNeil, Robert W Fernandez, Patrick Gomez Menzies, Tingting Gu, Jeremy Buhler, Elaine R Mardis, Sarah C R Elgin
The discordance between genome size and the complexity of eukaryotes can partly be attributed to differences in repeat density. The Muller F element (~5.2 Mb) is the smallest chromosome in Drosophila melanogaster, but it is substantially larger (>18.7 Mb) in Drosophila ananassae To identify the major contributors to the expansion of the F element and to assess their impact, we improved the genome sequence and annotated the genes in a 1.4 Mb region of the D. ananassae F element, and a 1.7 Mb region from the D element for comparison...
June 30, 2017: G3: Genes—Genomes—Genetics
https://www.readbyqxmd.com/read/28643753/dosimetric-characteristic-of-physical-wedge-versus-enhanced-dynamic-wedge-based-on-monte-carlo-simulations
#11
Seied Rabie Mahdavi, Ghazale Geraily, Ahmad Mostaar, Arman Zia, Golbarg Esmaili, Somayeh Farahani
AIM OF STUDY: Physical wedges (PWs) are widely used in radiotherapy to obtain tilted isodose curves, but they alter beam quality. Dynamic wedges (DWs) using moving collimator overcome this problem, but measuring their beam data is not simple. The main aim of this study is to obtain all dosimetric parameters of DWs produced by Varian 2100CD with Monte Carlo simulation and compare them to those from PWs. SUBJECTS AND METHODS: To simulate 6 MV photon beams equipped with PW and DW, BEAMnrc code was used...
April 2017: Journal of Cancer Research and Therapeutics
https://www.readbyqxmd.com/read/28629463/how-understanding-and-application-of-drug-related-legal-instruments-affects-harm-reduction-interventions-in-cambodia-a-qualitative-study
#12
Sovannary Tuot, Chanrith Ngin, Khuondyla Pal, Sochenda Sou, Ghazal Sawez, Phylicia Morgan, Mony Srey, Tola Chan, Pheak Chhoun, Olga Golichenko, Sok Chamreun Choub, Siyan Yi
BACKGROUND: Harm reduction interventions in Cambodia face numerous obstacles because of conflicting understanding and interests and inconsistencies in the implementation by law enforcement officials. This study aims to examine how understanding and application of Drug Control Law (DCL) and Village/Commune Safety Policy (VCSP) affects harm reduction interventions in Cambodia from the standpoints of law enforcement officials, people who inject drugs and people who use drugs (PWID/PWUD), as well as other key stakeholders...
June 19, 2017: Harm Reduction Journal
https://www.readbyqxmd.com/read/28619848/red-blood-cell-gardos-channel-kcnn4-the-essential-determinant-of-erythrocyte-dehydration-in-hereditary-xerocytosis
#13
Raphaël Rapetti-Mauss, Véronique Picard, Corinne Guitton, Khaldoun Ghazal, Valérie Proulle, Catherine Badens, Olivier Soriani, Loïc Garçon, Hélène Guizouarn
No abstract text is available yet for this article.
June 15, 2017: Haematologica
https://www.readbyqxmd.com/read/28610408/knowledge-and-awareness-about-cervical-cancer-vaccine-hpv-among-parents-in-sharjah
#14
Ahmad Saqer, Shaymaa Ghazal, Hiba Barqawi, Juman Adnan Babi, Ranya AlKhafaji, Mohamed Mohsen Elmekresh
Background and aim: Cervical cancer (CC) is the 7th most common cancer worldwide. It is the 4th most common cancer in females causing 7.5% of all female cancer deaths. Human Papilloma Virus (HPV) infection is the leading cause of CC and other diseases worldwide. Despite several measures taken to reduce the risk of infection with HPV, the most effective method remains the HPV vaccine. The aim of this study was to assess the knowledge and attitudes of parents in Sharjah towards HPV and whether or not they would vaccinate their daughters...
May 1, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/28610407/lack-of-hpv-in-benign-and-malignant-epithelial-ovarian-tumors-in-iran
#15
Farah Farzaneh, Seyed Alireza Nadji, Donya Khosravi, Maryam Sadat Hosseini, Mohammad Hashemi Bahremani, Mohammad Chehrazi, Ghazal Bagheri, Afsaneh Sigaroodi, Zahra Haghighatian
Background: Ovarian epithelial tumors one of the most common gynecological neoplasms; we here evaluated the presence of HPV in benign and malignant examples. Methods: In this cross-sectional study the records of 105 patients with epithelial ovarian tumors (benign and malignant) referred to Imam Hossein University Hospital from 2012 to 2015 were evaluated along with assessment of the presence of the HPV infection using PCR. Results: Among 105 patients, comprising 26 (24.8%) with malignant and 79 (75.2%) with benign lesions, the factors found to impact on malignancy were age at diagnosis, age at first pregnancy, number of pregnancies and hormonal status...
May 1, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/28575965/a-review-of-biocompatible-metal-injection-moulding-process-parameters-for-biomedical-applications
#16
REVIEW
M F F A Hamidi, W S W Harun, M Samykano, S A C Ghani, Z Ghazalli, F Ahmad, A B Sulong
Biocompatible metals have been revolutionizing the biomedical field, predominantly in human implant applications, where these metals widely used as a substitute to or as function restoration of degenerated tissues or organs. Powder metallurgy techniques, in specific the metal injection moulding (MIM) process, have been employed for the fabrication of controlled porous structures used for dental and orthopaedic surgical implants. The porous metal implant allows bony tissue ingrowth on the implant surface, thereby enhancing fixation and recovery...
September 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28558213/phthalocyanines-and-tetrapyrazinoporphyrazines-with-two-cationic-donuts-high-photodynamic-activity-as-a-result-of-rigid-spatial-arrangement-of-peripheral-substituents
#17
Basma Ghazal, Miloslav Machacek, Mona Abbas Shalaby, Veronika Novakova, Petr Zimcik, Saad Makhseed
High photodynamic activity was observed for hexadeca-cationic zinc, magnesium, and metal-free phthalocyanines (Pcs) and tetrapyrazinoporphyrazines with EC50 values as low as 5 nM (MCF-7 cells) for the best compound; this activity was several times better than that of clinically established photosensitizers verteporfin, temoporfin, S3AlOHPc, or protoporphyrin IX. This lead compound was characterized by low dark toxicity (TC50 = 369 μM), high efficiency against other cell lines (HCT 116 and HeLa), and possible activation by light above 680 nm...
July 27, 2017: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28557903/functional-recovery-following-early-kyphoplasty-versus-conservative-management-in-stable-thoracuolumbar-fractures-in-parachute-jumpers-a-randomized-clinical-trial
#18
Mohammad S Masoudi, Ali Haghnegahdar, Fariborz Ghaffarpasand, Ghazal Ilami
STUDY DESIGN: A randomized clinical trial. OBJECTIVE: To compare the functional recovery between early kyphoplasty and conservative care in paratroopers with stable thoracolumbar fractures. SUMMARY OF BACKGROUND DATA: Treatment of traumatic stable thoracolumbar fractures in young individuals is still a debate. Conservative management and kyphoplasty are options of therapy. But enough data are not available for supporting each. METHODS: We included 70 paratroopers with stable thoracolumbar fractures (A1 and A2 classification according to AOSpine thoracolumbar spine injury classification system) presenting <60 days after trauma and hyperintensity in T2-weighted magnetic resonance imaging...
May 26, 2017: Clinical Spine Surgery
https://www.readbyqxmd.com/read/28527605/analysis-of-gafchromic-ebt3-film-calibration-irradiated-with-gamma-rays-from-different-systems-gamma-knife-and-cobalt-60-unit
#19
Monsen Najafi, Ghazale Geraily, Alireza Shirazi, Mahbod Esfahani, Javad Teimouri
In recent years, Gafchromic films are used as an advanced instrument for dosimetry systems. The EBT3 films are a new generation of Gafchromic films. Our main interest is to compare the response of the EBT3 films exposed to gamma rays provided by the Theratron 780C as a conventional radiotherapy system and the Leksell Gamma Knife as a stereotactic radiotherapy system (SRS). Both systems use Cobalt-60 sources, thus using the same energy. However, other factors such as source-to-axis distance, number of sources, dose rate, direction of irradiation, shape of phantom, the field shape of radiation, and different scatter contribution may influence the calibration curve...
May 17, 2017: Medical Dosimetry: Official Journal of the American Association of Medical Dosimetrists
https://www.readbyqxmd.com/read/28515614/symmetrical-peripheral-gangrene-in-severe-plasmodium-vivax-malaria
#20
Prabhat Kumar, Ghazal Tansir, Harish Gupta, Juhi Dixit
No abstract text is available yet for this article.
April 2017: Indian Journal of Critical Care Medicine
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