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Jean-Louis Vincent

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https://www.readbyqxmd.com/read/30514349/impaired-cerebral-autoregulation-is-associated-with-brain-dysfunction-in-patients-with-sepsis
#1
Ilaria Alice Crippa, Carles Subirà, Jean-Louis Vincent, Rafael Fernandez Fernandez, Silvia Cano Hernandez, Federica Zama Cavicchi, Jacques Creteur, Fabio Silvio Taccone
BACKGROUND: Sepsis-associated brain dysfunction (SABD) is associated with high morbidity and mortality. The pathophysiology of SABD is multifactorial. One hypothesis is that impaired cerebral autoregulation (CAR) may result in brain hypoperfusion and neuronal damage leading to SABD. METHODS: We studied 100 adult patients with sepsis (July 2012-March 2017) (age = 62 [52-71] years; Acute Physiology and Chronic Health Evaluation II score on admission = 21 [15-26])...
December 4, 2018: Critical Care: the Official Journal of the Critical Care Forum
https://www.readbyqxmd.com/read/30488607/cell-seeding-on-uv-c-treated-3d-polymeric-templates-allows-for-cost-effective-production-of-small-caliber-tissue-engineered-blood-vessels
#2
Todd Galbraith, Vincent Roy, Jean-Michel Bourget, Tamao Tsutsumi, Maxime Picard-Deland, Jean-François Morin, Robert Gauvin, Ashraf A Ismail, François A Auger, François Gros-Louis
There is a strong clinical need to develop small-caliber tissue-engineered blood vessels for arterial bypass surgeries. Such substitutes can be engineered using the self-assembly approach in which cells produce their own extracellular matrix (ECM), creating a robust vessel without exogenous material. However, this approach is currently limited to the production of flat sheets that need to be further rolled into the final desired tubular shape. In this study, human fibroblasts and smooth muscle cells were seeded directly on UV-C-treated cylindrical polyethylene terephthalate glycol-modified (PETG) mandrels of 4...
November 28, 2018: Biotechnology Journal
https://www.readbyqxmd.com/read/30464347/amphioxus-functional-genomics-and-the-origins-of-vertebrate-gene-regulation
#3
Ferdinand Marlétaz, Panos N Firbas, Ignacio Maeso, Juan J Tena, Ozren Bogdanovic, Malcolm Perry, Christopher D R Wyatt, Elisa de la Calle-Mustienes, Stephanie Bertrand, Demian Burguera, Rafael D Acemel, Simon J van Heeringen, Silvia Naranjo, Carlos Herrera-Ubeda, Ksenia Skvortsova, Sandra Jimenez-Gancedo, Daniel Aldea, Yamile Marquez, Lorena Buono, Iryna Kozmikova, Jon Permanyer, Alexandra Louis, Beatriz Albuixech-Crespo, Yann Le Petillon, Anthony Leon, Lucie Subirana, Piotr J Balwierz, Paul Edward Duckett, Ensieh Farahani, Jean-Marc Aury, Sophie Mangenot, Patrick Wincker, Ricard Albalat, Èlia Benito-Gutiérrez, Cristian Cañestro, Filipe Castro, Salvatore D'Aniello, David E K Ferrier, Shengfeng Huang, Vincent Laudet, Gabriel A B Marais, Pierre Pontarotti, Michael Schubert, Hervé Seitz, Ildiko Somorjai, Tokiharu Takahashi, Olivier Mirabeau, Anlong Xu, Jr-Kai Yu, Piero Carninci, Juan Ramon Martinez-Morales, Hugues Roest Crollius, Zbynek Kozmik, Matthew T Weirauch, Jordi Garcia-Fernàndez, Ryan Lister, Boris Lenhard, Peter W H Holland, Hector Escriva, Jose Luis Gómez-Skarmeta, Manuel Irimia
Vertebrates have greatly elaborated the basic chordate body plan and evolved highly distinctive genomes that have been sculpted by two whole-genome duplications. Here we sequence the genome of the Mediterranean amphioxus (Branchiostoma lanceolatum) and characterize DNA methylation, chromatin accessibility, histone modifications and transcriptomes across multiple developmental stages and adult tissues to investigate the evolution of the regulation of the chordate genome. Comparisons with vertebrates identify an intermediate stage in the evolution of differentially methylated enhancers, and a high conservation of gene expression and its cis-regulatory logic between amphioxus and vertebrates that occurs maximally at an earlier mid-embryonic phylotypic period...
November 21, 2018: Nature
https://www.readbyqxmd.com/read/30456467/fluid-administration-for-acute-circulatory-dysfunction-using-basic-monitoring-narrative-review-and-expert-panel-recommendations-from-an-esicm-task-force
#4
Maurizio Cecconi, Glenn Hernandez, Martin Dunser, Massimo Antonelli, Tim Baker, Jan Bakker, Jacques Duranteaum, Sharon Einav, A B Johan Groeneveld, Tim Harris, Sameer Jog, Flavia R Machado, Mervyn Mer, M Ignacio Monge Garcia, Sheila Nainan Myatra, Anders Perner, Jean-Louis Teboul, Jean-Louis Vincent, Daniel De Backer
An international team of experts in the field of fluid resuscitation was invited by the ESICM to form a task force to systematically review the evidence concerning fluid administration using basic monitoring. The work included a particular emphasis on pre-ICU hospital settings and resource-limited settings. The work focused on four main questions: (1) What is the role of clinical assessment to guide fluid resuscitation in shock? (2) What basic monitoring is required to perform and interpret a fluid challenge? (3) What defines a fluid challenge in terms of fluid type, ranges of volume, and rate of administration? (4) What are the safety endpoints during a fluid challenge? The expert panel found insufficient evidence to provide recommendations according to the GRADE system, and was only able to make recommendations for basic interventions, based on the available evidence and expert opinion...
November 19, 2018: Intensive Care Medicine
https://www.readbyqxmd.com/read/30451667/-the-most-ancestral-mycobacterial-esx-4-secretion-system-is-essential-for-intracellular-growth-of-mycobacterium-abscessus-within-environmental-and-human-phagocytes
#5
Fabienne Girard-Misguich, Laura Laencina, Violaine Dubois, Vincent Le Moigne, Laurent Kremer, Laleh Maljessi, Roland Brosch, Jean-Louis Herrmann
No abstract text is available yet for this article.
October 2018: Médecine Sciences: M/S
https://www.readbyqxmd.com/read/30445934/pattern-of-care-of-prostate-cancer-patients-across-the-martinique-results-of-a-population-based-study-in-the-caribbean
#6
Clarisse Joachim, Jacqueline Veronique-Baudin, Stephen Ulric-Gervaise, Jonathan Macni, Thierry Almont, Olivier Pierre-Louis, Lidvine Godaert, Moustapha Drame, Jean-Luc Novella, Karim Farid, Vincent Vinh-Hung, Patrick Escarmant
BACKGROUND: The French West-Indies rank first for both prostate cancer incidence and mortality rates. Analyzing diagnostic and therapeutic procedures among patients with prostate cancer, using data from a population-based cancer registry, is essential for cancer surveillance and research strategies. METHODS: This retrospective observational cohort study was based on data from the Martinique Cancer Registry. Records of 452 patients diagnosed with prostate cancer in 2013 were retrieved from the registry...
November 16, 2018: BMC Cancer
https://www.readbyqxmd.com/read/30418217/long-term-impact-of-crystalloid-versus-colloid-solutions-on-renal-function-and-disability-free-survival-after-major-abdominal-surgery
#7
Alexandre Joosten, Amélie Delaporte, Julien Mortier, Brigitte Ickx, Luc Van Obbergh, Jean-Louis Vincent, Maxime Cannesson, Joseph Rinehart, Philippe Van der Linden
WHAT WE ALREADY KNOW ABOUT THIS TOPIC: WHAT THIS ARTICLE TELLS US THAT IS NEW: BACKGROUND:: The authors recently demonstrated that administration of balanced hydroxyethyl starch solution as part of intraoperative goal-directed fluid therapy was associated with better short-term outcomes than administration of a balanced crystalloid solution in patients having major open abdominal surgery. In the present study, a 1-yr follow-up of renal and disability outcomes in these patients was performed...
November 9, 2018: Anesthesiology
https://www.readbyqxmd.com/read/30411243/mean-arterial-pressure-and-mortality-in-patients-with-distributive-shock-a-retrospective-analysis-of-the-mimic-iii-database
#8
Jean-Louis Vincent, Nathan D Nielsen, Nathan I Shapiro, Margaret E Gerbasi, Aaron Grossman, Robin Doroff, Feng Zeng, Paul J Young, James A Russell
BACKGROUND: Maintenance of mean arterial pressure (MAP) at levels sufficient to avoid tissue hypoperfusion is a key tenet in the management of distributive shock. We hypothesized that patients with distributive shock sometimes have a MAP below that typically recommended and that such hypotension is associated with increased mortality. METHODS: In this retrospective analysis of the Medical Information Mart for Intensive Care (MIMIC-III) database from Beth Israel Deaconess Medical Center, Boston, USA, we included all intensive care unit (ICU) admissions between 2001 and 2012 with distributive shock, defined as continuous vasopressor support for ≥ 6 h and no evidence of low cardiac output shock...
November 8, 2018: Annals of Intensive Care
https://www.readbyqxmd.com/read/30410123/impact-of-non-alcoholic-fatty-liver-disease-on-long-term-cardiovascular-events-and-death-in-chronic-obstructive-pulmonary-disease
#9
Damien Viglino, Anais Plazanet, Sebastien Bailly, Meriem Benmerad, Ingrid Jullian-Desayes, Renaud Tamisier, Vincent Leroy, Jean-Pierre Zarski, Maxime Maignan, Marie Joyeux-Faure, Jean-Louis Pépin
Chronic Obstructive Pulmonary Disease (COPD) and Non-Alcoholic Fatty Liver Disease (NAFLD) both independently increase cardiovascular risk. We hypothesized that NAFLD might increase the incidence of cardiovascular disease and death in COPD patients. The relationship between NAFLD, incident cardiovascular events, and death was assessed in a prospective cohort of COPD patients with 5-year follow-up. Noninvasive algorithms combining biological parameters (FibroMax® ) were used to evaluate steatosis, non-alcoholic steatohepatitis (NASH) and liver fibrosis...
November 8, 2018: Scientific Reports
https://www.readbyqxmd.com/read/30401576/an-international-perspective-on-hospitalized-patients-with-viral-community-acquired-pneumonia
#10
Dejan Radovanovic, Giovanni Sotgiu, Mateja Jankovic, Padukudru Anand Mahesh, Pedro Jorge Marcos, Mohamed I Abdalla, Marta Francesca Di Pasquale, Andrea Gramegna, Silvia Terraneo, Francesco Blasi, Pierachille Santus, Stefano Aliberti, Luis F Reyes, Marcos I Restrepo, Patricia Karina Aruj, Silvia Attorri, Enrique Barimboim, Juan Pablo Caeiro, María I Garzón, Victor Hugo Cambursano, Adrian Ceccato, Julio Chertcoff, Ariel Cordon Díaz, Lautaro de Vedia, Maria Cristina Ganaha, Sandra Lambert, Gustavo Lopardo, Carlos M Luna, Alessio Gerardo Malberti, Nora Morcillo, Silvina Tartara, Claudia Pensotti, Betiana Pereyra, Pablo Gustavo Scapellato, Juan Pablo Stagnaro, Sonali Shah, Felix Lötsch, Florian Thalhammer, Kurt Anseeuw, Camille A Francois, Eva Van Braeckel, Jean Louis Vincent, Marcel Zannou Djimon, Simone Aranha Nouér, Peter Chipev, Milena Encheva, Darina Miteva, Diana Petkova, Adamou Dodo Balkissou, Eric Walter Pefura Yone, Bertrand Hugo Mbatchou Ngahane, Ning Shen, Jin-Fu Xu, Carlos Andres Bustamante Rico, Ricardo Buitrago, Fernando Jose Pereira Paternina, Jean-Marie Kayembe Ntumba, Vesna Vladic-Carevic, Marko Jakopovic, Zinka Matkovic, Ivan Mitrecic, Marie-Laure Bouchy Jacobsson, Anette Bro Christensen, Uffe Christian Heitmann Bødtger, Christian Niels Meyer, Andreas Vestergaard Jensen, Ibrahim El-Said Abd El-Wahhab, Nesreen Elsayed Morsy, Hanaa Shafiek, Eman Sobh, Kedir Abdella Abdulsemed, Fabrice Bertrand, Christian Brun-Buisson, Etienne de Montmollin, Muriel Fartoukh, Jonathan Messika, Pierre Tattevin, Abdo Khoury, Bernard Ebruke, Michael Dreher, Martin Kolditz, Matthias Meisinger, Mathias W Pletz, Stefan Hagel, Jan Rupp, Tom Schaberg, Marc Spielmanns, Petra Creutz, Norton Suttorp, Beatrice Siaw-Lartey, Katerina Dimakou, Dimosthenis Papapetrou, Evdoxia Tsigou, Dimitrios Ampazis, Evangelos Kaimakamis, Mohit Bhatia, Raja Dhar, George D'Souza, Rajiv Garg, Parvaiz A Koul, B S Jayaraj, Kiran Vishnu Narayan, Hirennappa B Udnur, Shashi Bhaskara Krishnamurthy, Surya Kant, Rajesh Swarnakar, Sundeep Salvi, Sneha Limaye, Keihan Golshani, Vera M Keatings, Ignacio Martin-Loeches, Yasmin Maor, Jacob Strahilevitz, Salvatore Battaglia, Maria Carrabba, Piero Ceriana, Marco Confalonieri, Antonella d'Arminio Monforte, Bruno Del Prato, Marino De Rosa, Riccardo Fantini, Giuseppe Fiorentino, Maria Antonia Gammino, Francesco Menzella, Giuseppe Milani, Stefano Nava, Gerardo Palmiero, Roberta Petrino, Barbra Gabrielli, Paolo Rossi, Claudio Sorino, Gundi Steinhilber, Alessandro Zanforlin, Fabio Franzetti, Mauro Carone, Vincenzo Patella, Simone Scarlata, Andrea Comel, Kiyoyasu Kurahashi, Zeina Aoun Bacha, Daniel Barajas Ugalde, Omar Ceballos Zuñiga, José F Villegas, Milic Medenica, E M W van de Garde, Deebya Raj Mihsra, Poojan Shrestha, Elliott Ridgeon, Babatunde Ishola Awokola, Ogonna N O Nwankwo, Adefuye Bolanle Olufunlola, Segaolu Olumide, Kingsley N Ukwaja, Muhammad Irfan, Lukasz Minarowski, Skoczyński Szymon, Felipe Froes, Pedro Leuschner, Mariana Meireles, Cláudia Ferrão, Pedro Leuschner, João Neves, Sofia B Ravara, Victoria Brocovschii, Chesov Ion, Doina Rusu, Cristina Toma, Daniela Chirita, Carmen Mihaela Dorobat, Alexei Birkun, Anna Kaluzhenina, Abdullah Almotairi, Zakeya Abdulbaqi Ali Bukhary, Jameela Edathodu, Amal Fathy, Abdullah Mushira Abdulaziz Enani, Nazik Eltayeb Mohamed, Jawed Ulhadi Memon, Abdelhaleem Bella, Nada Bogdanović, Branislava Milenkovic, Dragica Pesut, Luis Borderìas, Noel Manuel Bordon Garcia, Hugo Cabello Alarcón, Catia Cilloniz, Antoni Torres, Vicens Diaz-Brito, Xavier Casas, Alicia Encabo González, Maria Luisa Fernández-Almira, Miguel Gallego, Inmaculada Gaspar-GarcÍa, Juan González Del Castillo, Patricia Javaloyes Victoria, Elena Laserna Martínez, Rosa Malo de Molina, Rosario Menéndez, Ana Pando-Sandoval, Cristina Prat Aymerich, Alicia Lacoma de la Torre, Ignasi García-Olivé, Jordi Rello, Silvia Moyano, Francisco Sanz, Oriol Sibila, Ana Rodrigo-Troyano, Jordi Solé-Violán, Ane Uranga, Job F M van Boven, Ester Vendrell Torra, Jordi Almirall Pujol, Charles Feldman, Ho Kee Yum, Arnauld Attannon Fiogbe, Ferdaous Yangui, Semra Bilaceroglu, Levent Dalar, Ufuk Yilmaz, Artemii Bogomolov, Naheed Elahi, Devesh J Dhasmana, Andrew Feneley, Carole Hancock, Adam T Hill, Banu Rudran, Silvia Ruiz-Buitrago, Marion Campbell, Paul Whitaker, Alexander Youzguin, Anika Singanayagam, Karen S Allen, Veronica Brito, Jessica Dietz, Claire E Dysart, Susan M Kellie, Ricardo A Franco-Sadud, Garnet Meier, Mina Gaga, Thomas L Holland, Stephen P Bergin, Fayez Kheir, Mark Landmeier, Manuel Lois, Girish B Nair, Hemali Patel, Katherine Reyes, William Rodriguez-Cintron, Shigeki Saito, Nilam J Soni, Julio Noda, Cecilia I Hinojosa, Stephanie M Levine, Luis F Angel, Antonio Anzueto, K Scott Whitlow, John Hipskind, Kunal Sukhija, Vicken Totten, Richard G Wunderink, Ray D Shah, Kondwelani John Mateyo, Manuela Carugati, Manuela Morosi, Elisa Monge
BACKGROUND: Who should be tested for viruses in patients with community acquired pneumonia (CAP), prevalence and risk factors for viral CAP are still debated. We evaluated the frequency of viral testing, virus prevalence, risk factors and treatment coverage with oseltamivir in patients admitted for CAP. METHODS: Secondary analysis of GLIMP, an international, multicenter, point-prevalence study of hospitalized adults with CAP. Testing frequency, prevalence of viral CAP and treatment with oseltamivir were assessed among patients who underwent a viral swab...
November 3, 2018: European Journal of Internal Medicine
https://www.readbyqxmd.com/read/30383568/impact-of-cytomegalovirus-infection-on-the-outcome-of-patients-with-cirrhosis-a-preliminary-study
#11
Morgan Faivre, Vanessa Cottet, Jean-Baptiste Bour, Carine Richou, Séverine Valmary-Degano, Gerard Thiefin, Laurent Andreoletti, Claire Geist, Evelyne Schvoerer, Brice Malvé, François Habersetzer, Samira Fafi-Kremer, Christine Binquet, Jean-Louis Jouve, Jean-Pierre Bronowicki, Michel Doffoel, Patrick Hillon, Georges Herbein, Elisabeth Monnet, Vincent Di Martino
GOALS: The aims of this study were to evaluate whether cytomegalovirus (CMV) infection is associated with hepatocellular carcinoma (HCC) and liver-related mortality in cirrhotic patients. BACKGROUND: In cirrhotic patients, the determinants of HCC and liver-related death are imperfectly known. CMV infection, by its prooncogenic and proinflammatory properties, may favor both the development of HCC and deleterious systemic inflammation. STUDY: In the 1178 patients included between June 2008 and December 2012 in the CIrrhose et Risque de Carcinome Hépatocellulaire dans le grand-Est (CIRCE) study, a French multicenter case-control study designed to identify risk factors of HCC among cirrhotic patients, we identified 432 patients with interpretable CMV serological status at baseline...
October 31, 2018: Journal of Clinical Gastroenterology
https://www.readbyqxmd.com/read/30357270/effect-of-high-flow-nasal-oxygen-vs-standard-oxygen-on-28-day-mortality-in-immunocompromised-patients-with-acute-respiratory-failure-the-high-randomized-clinical-trial
#12
Elie Azoulay, Virginie Lemiale, Djamel Mokart, Saad Nseir, Laurent Argaud, Frédéric Pène, Loay Kontar, Fabrice Bruneel, Kada Klouche, François Barbier, Jean Reignier, Lilia Berrahil-Meksen, Guillaume Louis, Jean-Michel Constantin, Julien Mayaux, Florent Wallet, Achille Kouatchet, Vincent Peigne, Igor Théodose, Pierre Perez, Christophe Girault, Samir Jaber, Johanna Oziel, Martine Nyunga, Nicolas Terzi, Lila Bouadma, Christine Lebert, Alexandre Lautrette, Naike Bigé, Jean-Herlé Raphalen, Laurent Papazian, Michael Darmon, Sylvie Chevret, Alexandre Demoule
Importance: High-flow nasal oxygen therapy is increasingly used for acute hypoxemic respiratory failure (AHRF). Objective: To determine whether high-flow oxygen therapy decreases mortality among immunocompromised patients with AHRF compared with standard oxygen therapy. Design, Setting, and Participants: The HIGH randomized clinical trial enrolled 776 adult immunocompromised patients with AHRF (Pao2 <60 mm Hg or Spo2 <90% on room air, or tachypnea >30/min or labored breathing or respiratory distress, and need for oxygen ≥6 L/min) at 32 intensive care units (ICUs) in France between May 19, 2016, and December 31, 2017...
November 27, 2018: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/30345654/olfactory-function-in-patients-with-nonsyndromic-orofacial-clefts-and-their-unaffected-relatives
#13
Jasmien Roosenboom, Robert Hermans, Frederik Lammens, Jean Louis Samain, Koen Devriendt, Vincent Vander Poorten, Peter W Hellings, Mark Jorissen, Hilde Peeters, Peter Claes, Greet Hens
Nonsyndromic orofacial clefting is one of the most frequently occurring congenital conditions. The aim of the study was to investigate the prevalence and nature of reduced olfactory function in patients with nonsyndromic cleft lip and/or cleft palate (NSCL/P) and their unaffected first-degree relatives. Olfactory function was tested using the Sniffin' Sticks identification test in patients with NSCL/P, in their unaffected relatives, and in control subjects. MR imaging was performed to measure olfactory bulb (OB) volumes and olfactory sulcus (OS) depths...
October 22, 2018: American Journal of Medical Genetics. Part A
https://www.readbyqxmd.com/read/30333160/who-should-undergo-a-comprehensive-cognitive-assessment-after-a-stroke-a-cognitive-risk-score
#14
Olivier Godefroy, Hugo Yaïche, Hervé Taillia, Flavie Bompaire, Claudine Nédélec-Ciceri, Camille Bonnin, Jérôme Varvat, Françoise Vincent-Grangette, Momar Diouf, Jean-Louis Mas, Sandrine Canaple, Chantal Lamy, Audrey Arnoux, Claire Leclercq, Sophie Tasseel-Ponche, Martine Roussel, Mélanie Barbay
OBJECTIVE: To validate the ability of a specifically developed cognitive risk score to identify patients at risk of poststroke neurocognitive disorders (NCDs) who are eligible for a comprehensive cognitive assessment. METHODS: After assessing 404 patients (infarct 91.3%) in the Groupe de Réflexion pour l'Evaluation Cognitive VASCulaire (GRECogVASC) cross-sectional study with the National Institute of Neurological Disorders and Stroke-Canadian Stroke Network battery 6 months after stroke, we used multivariable logistic regression and bootstrap analyses to determine factors associated with NCDs...
October 17, 2018: Neurology
https://www.readbyqxmd.com/read/30326692/anterior-bone-loss-in-cervical-disc-arthroplasty
#15
David Christopher Kieser, Derek Thomas Cawley, Takashi Fujishiro, Celeste Tavolaro, Simon Mazas, Louis Boissiere, Ibrahim Obeid, Vincent Pointillart, Jean Marc Vital, Olivier Gille
Study Design: Retrospective, longitudinal observational study. Purpose: To describe the natural history of anterior bone loss (ABL) in cervical disc arthroplasty (CDA) and introduce a classification system for its assessment. Overview of Literature: ABL has recently been recognized as a complication of CDA, but its cause and clinical effects remain unknown. Methods: Patients with non-keeled CDA (146) were retrospectively reviewed...
October 18, 2018: Asian Spine Journal
https://www.readbyqxmd.com/read/30320743/identification-of-virulence-markers-of-mycobacterium-abscessus-for-intracellular-replication-in-phagocytes
#16
Violaine Dubois, Laura Laencina, Anouchka Bories, Vincent Le Moigne, Alexandre Pawlik, Jean-Louis Herrmann, Fabienne Girard-Misguich
What differentiates Mycobacterium abscessus from other saprophytic mycobacteria is the ability to resist phagocytosis by human macrophages and the ability to multiply inside such cells. These virulence traits render M. abscessus pathogenic, especially in vulnerable hosts with underlying structural lung disease, such as cystic fibrosis, bronchiectasis or tuberculosis. How patients become infected with M. abscessus remains unclear. Unlike many mycobacteria, M. abscessus is not found in the environment but might reside inside amoebae, environmental phagocytes that represent a potential reservoir for M...
September 27, 2018: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/30315330/how-i-treat-septic-shock
#17
EDITORIAL
Jean-Louis Vincent
No abstract text is available yet for this article.
October 12, 2018: Intensive Care Medicine
https://www.readbyqxmd.com/read/30307953/pulmonary-hypertension-targeted-therapies-in-heart-failure-a-systematic-review-and-meta-analysis
#18
Charles-Antoine Guay, Louis-Vincent Morin-Thibault, Sebastien Bonnet, Yves Lacasse, Caroline Lambert, Jean-Christophe Lega, Steeve Provencher
BACKGROUND: Pulmonary hypertension (PH) due to left heart failure (HF) is the most common form of PH. However, treatment is unclear because there are conflicting results about safety and efficacy of PH-targeted therapies. OBJECTIVES: To assess the effects of PH-targeted therapy on exercise capacity in HF patients. METHODS: MEDLINE, EMBASE and the Cochrane Library were searched from January 1990 to July 2017 for randomized controlled trials comparing PH-targeted therapies to conventional therapy in HF...
2018: PloS One
https://www.readbyqxmd.com/read/30304716/introduction-to-extracorporeal-multiple-organ-support
#19
EDITORIAL
Jean-Louis Vincent
No abstract text is available yet for this article.
October 10, 2018: Blood Purification
https://www.readbyqxmd.com/read/30301802/mmpl8-mab-controls-mycobacterium-abscessus-virulence-and-production-of-a-previously-unknown-glycolipid-family
#20
Violaine Dubois, Albertus Viljoen, Laura Laencina, Vincent Le Moigne, Audrey Bernut, Faustine Dubar, Mickaël Blaise, Jean-Louis Gaillard, Yann Guérardel, Laurent Kremer, Jean-Louis Herrmann, Fabienne Girard-Misguich
Mycobacterium abscessus is a peculiar rapid-growing Mycobacterium (RGM) capable of surviving within eukaryotic cells thanks to an arsenal of virulence genes also found in slow-growing mycobacteria (SGM), such as Mycobacterium tuberculosis A screen based on the intracellular survival in amoebae and macrophages (MΦ) of an M. abscessus transposon mutant library revealed the important role of MAB_0855, a yet uncharacterized Mycobacterial membrane protein Large (MmpL). Large-scale comparisons with SGM and RGM genomes uncovered MmpL12 proteins as putative orthologs of MAB_0855 and a locus-scale synteny between the MAB_0855 and Mycobacterium chelonae mmpL8 loci...
October 23, 2018: Proceedings of the National Academy of Sciences of the United States of America
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