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Jean-Louis Vincent

Duc Nam Nguyen, Luc Huyghens, Jose Parra, Johan Schiettecatte, Johan Smitz, Jean-Louis Vincent
The pathogenesis of delirium in critically ill patients is multifactorial. How hypotension and hypoxemia affect brain function and whether they can promote delirium remains unclear. A high cumulative positive fluid balance may also have a negative effect on brain function and promote delirium. We hypothesized that delirium would be more likely to develop in patients with low systemic arterial pressure, hypoxemia and a higher positive fluid balance, and investigated these associations in a prospective observational cohort study in patients with shock...
2018: PloS One
Esther Peters, Massimo Antonelli, Xavier Wittebole, Rahul Nanchal, Bruno François, Yasser Sakr, Jean-Louis Vincent, Peter Pickkers
BACKGROUND: Acute kidney injury (AKI) is a common complication of critical illness and is associated with worse outcomes. However, the influence of deterioration or improvement in renal function on clinical outcomes is unclear. Using a large international database, we evaluated the prevalence and evolution of AKI over a 7-day period and its effects on clinical outcomes in septic and non-septic critically ill patients worldwide. METHODS: From the 10,069 adult intensive care unit (ICU) patients in the Intensive Care Over Nations database, all those with creatinine and urine output data were included in this substudy...
August 3, 2018: Critical Care: the Official Journal of the Critical Care Forum
Mathilde Nativel, Fabrice Schneider, Pierre-Jean Saulnier, Elise Gand, Stéphanie Ragot, Olivier Meilhac, Philippe Rondeau, Elena Burillo, Maxime Cournot, Louis Potier, Gilberto Velho, Michel Marre, Ronan Roussel, Vincent Rigalleau, Kamel Mohammedi, Samy Hadjadj
OBJECTIVE: Inflammation and oxidative stress play an important role in the pathogenesis of lower-extremity artery disease (LEAD). We assessed the prognostic values of inflammatory and redox status biomarkers on the risk of LEAD in individuals with type 2 diabetes. RESEARCH DESIGN AND METHODS: Plasma concentrations of tumor necrosis factor-α receptor 1 (TNFR1), angiopoietin-like 2, ischemia-modified albumin (IMA), fluorescent advanced glycation end products, protein carbonyls, and total reductive capacity of plasma were measured at baseline in the SURDIAGENE (Survie, Diabete de type 2 et Genetique) cohort...
August 2, 2018: Diabetes Care
Laurent Opsomer, Vincent Théate, Philippe Lefèvre, Jean-Louis Thonnard
Predicting the consequences of one's own movements can be challenging when confronted with completely novel environmental dynamics, such as microgravity in space. The absence of gravitational force disrupts internal models of the central nervous system (CNS) that have been tuned to the dynamics of a constant 1- g environment since birth. In the context of object manipulation, inadequate internal models produce prediction uncertainty evidenced by increases in the grip force (GF) safety margin that ensures a stable grip during unpredicted load perturbations...
2018: Frontiers in Physiology
Luc Cabel, Emmanuelle Jeannot, Ivan Bièche, Sophie Vacher, Celine Callens, Louis Bazire, Adeline Morel, Alice Bernard-Tessier, Walid Chemlali, Anne Schnitzler, Astrid Lièvre, Joelle Otz, Mathieu Minsat, Anne Vincent-Salomon, Jean-Yves Pierga, Bruno Buecher, Pascale Mariani, Charlotte Proudhon, François-Clément Bidard, Wulfran Cacheux
PURPOSE: Chemoradiotherapy (CRT) is the current standard of care for patients diagnosed with locally advanced anal squamous cell carcinoma (ASCC), but some patients develop local and/or distant relapse during follow-up. The present study was designed to monitor HPV circulating tumor DNA (ctDNA) levels during CRT in patients with ASCC. EXPERIMENTAL DESIGN: We analyzed samples from patients with HPV16- or HPV18-positive locally advanced ASCC. Blood samples were collected before and after CRT...
July 27, 2018: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
Clarisse Joachim, Jacqueline Veronique-Baudin, Thierry Almont, Stephen Ulric-Gervaise, Jonathan Macni, Olivier Pierre-Louis, Lidvine Godaert, Moustapha Drame, Jean-Luc Novella, Karim Farid, Vincent Vinh-Hung, Patrick Escarmant
PURPOSE: Recording cancer data in cancer registries is essential for producing reliable population-based data for service planning, monitoring and evaluation. Prostate cancer (PCa) remains the most frequent type of cancer in terms of incidence and mortality in men in the Caribbean. The quality of life PCa cohort will assess quality of life and patient outcomes in Martinique using a digital platform for patient-reported outcome measures. PARTICIPANTS: The Martinique Cancer Registry database is the largest clinical database among the French population-based cancer registries in the Caribbean, including more than 38 000 cancer cases, with 1650 new cancer cases per year, including 550 new PCa cases per year (2010-2014 latest period)...
July 25, 2018: BMJ Open
Faeq Husain-Syed, Zaccaria Ricci, Daniel Brodie, Jean-Louis Vincent, V Marco Ranieri, Arthur S Slutsky, Fabio Silvio Taccone, Luciano Gattinoni, Claudio Ronco
The complex nature of single organ failure potentially leading to multiple organ dysfunction syndrome (MODS) in critically ill patients necessitates integrated supportive therapy. Rather than a primary disease, acute kidney injury (AKI) is considered a window to a potentially serious underlying systemic disease, which may partially explain the high morbidity and mortality rates associated with the condition. Renal replacement therapy (RRT) has been routinely used for more than a decade in various intensive care settings and there has also been an increase in the use of extracorporeal membrane oxygenation and extracorporeal carbon dioxide removal...
July 24, 2018: Intensive Care Medicine
Filippo Annoni, Antonio Maria Dell'Anna, Federico Franchi, Jacques Creteur, Sabino Scolletta, Jean-Louis Vincent, Fabio Silvio Taccone
AIM: Which haemodynamic variable is the best predictor of neurological outcome remains unclear. We investigated the association of several haemodynamic variables with neurological outcome in CA patients. METHODS: Retrospective analysis of adult comatose survivors of CA admitted to the intensive care unit (ICU) of a University Hospital. Exclusion criteria were early death due to withdrawal of care, missing haemodynamic data and use of intra-aortic balloon pump or extracorporeal membrane oxygenation...
July 19, 2018: Resuscitation
Jean Louis Raisaro, Gwangbae Choi, Sylvain Pradervand, Raphael Colsenet, Nathalie Jacquemont, Nicolas Rosat, Vincent Mooser, Jean-Pierre Hubaux
Re-use of patients' health records can provide tremendous benefits for clinical research. Yet, when researchers need to access sensitive/identifying data, such as genomic data, in order to compile cohorts of well-characterized patients for specific studies, privacy and security concerns represent major obstacles that make such a procedure extremely difficult if not impossible. In this paper, we address the challenge of designing and deploying in a real operational setting an efficient privacy-preserving explorer for genetic cohorts...
July 10, 2018: IEEE/ACM Transactions on Computational Biology and Bioinformatics
Alexandra Jacobs, Fabio Silvio Taccone, Jason A Roberts, Frédérique Jacobs, Frederic Cotton, Fleur Wolff, Jacques Creteur, Jean-Louis Vincent, Maya Hites
Augmented renal clearance is commonly observed in septic patients and may result in insufficient β-lactam serum concentrations. The aims of this study were to evaluate potential correlations between drug concentrations or total body clearance of β-lactam antibiotics and measured creatinine clearance, and to quantify the need for drug dosage adjustments in septic patients with different levels of augmented renal clearance. We reviewed 256 antibiotic measurements (512 drug concentrations) from a cohort of 215 critically ill patients with a measured creatinine clearance ≥ 120 mL/min, and who received therapeutic drug monitoring of meropenem, cefepime, ceftazidime or piperacillin from October 2009 until December 2014 at Erasme Hospital...
July 9, 2018: Antimicrobial Agents and Chemotherapy
Alexandre Joosten, Céline Boudart, Jean-Louis Vincent, Frederic Vanden Eynden, Luc Barvais, Luc Van Obbergh, Joseph Rinehart, Olivier Desebbe
BACKGROUND: Pulse pressure variation (PPV) can be used to predict fluid responsiveness in anesthetized patients receiving controlled mechanical ventilation but usually requires dedicated advanced monitoring. Capstesia (Galenic App, Vitoria-Gasteiz, Spain) is a novel smartphone application that calculates PPV and cardiac output (CO) from a picture of the invasive arterial pressure waveform obtained from any monitor screen. The primary objective was to compare the ability of PPV obtained using the Capstesia (PPVCAP) and PPV obtained using a pulse contour analysis monitor (PPVPC) to predict fluid responsiveness...
July 6, 2018: Anesthesia and Analgesia
Florent Olivon, Louis-Félix Nothias, Vincent Dumontet, Pascal Retailleau, Sylvie Berger, Gilles Ferry, William Cohen, Bruno Pfeiffer, Jean A Boutin, Elisabeth Scalbert, Fanny Roussi, Marc Litaudon
In an effort to find potent natural inhibitors of RhoA and p115 signaling G-proteins, a systematic in vitro evaluation using enzymatic and plasmonic resonance assays was undertaken on 11 317 plant extracts. The screening procedure led to the selection of the New Caledonian endemic species Meiogyne baillonii for a chemical investigation. Using a bioguided isolation procedure, three enediyne-γ-butyrolactones (1-3) and two enediyne-γ-butenolides (4 and 5), named sapranthins H-L, respectively, two enediyne carboxylic acid (6 and 7), two depsidones, stictic acid (8) and baillonic acid (9), aristolactams AIa and AIIa (10 and 11), and two aporphines, dehydroroemerine (12) and noraristolodione (13), were isolated from the ethyl acetate extract of the bark...
July 27, 2018: Journal of Natural Products
Jean-Louis Vincent, John J Marini, Antonio Pesenti
No abstract text is available yet for this article.
June 11, 2018: Intensive Care Medicine
Koji Hosokawa, Fuhong Su, Fabio Silvio Taccone, Emiel Hendrik Post, Jacques Creteur, Jean-Louis Vincent
BACKGROUND: Acute ethanol intoxication has been shown to have contrasting effects on outcomes in sepsis. The aim of this study was to explore the effects of acute ethanol intoxication on hemodynamics, renal function, brain perfusion and lactate/pyruvate in an ovine sepsis model. METHODS: Anesthetized, mechanically ventilated female sheep were randomized to an ethanol group (n = 7), which received 1 g/kg ethanol diluted in intravenous (i.v.) saline infusion or a control group (n = 7), which received the same volume of i...
June 19, 2018: BMC Anesthesiology
Di Zhang, Vincent Nourrit, Jean-Louis De Bougrenet de la Tocnaye
Random-dot stereograms have been widely used to explore the neural mechanisms underlying binocular vision. Although they are a powerful tool to stimulate motion-in-depth (MID) perception, published results report some difficulties in the capacity to perceive MID generated by random-dot stereograms. The purpose of this study was to investigate whether the performance of MID perception could be improved using an appropriate stimulus design. Sixteen inexperienced observers participated in the experiment. A training session was carried out to improve the accuracy of MID detection before the experiment...
July 2018: Perception
Jean-Louis Vincent, Pedro Castro, Beverley J Hunt, Achim Jörres, Manuel Praga, Jose Rojas-Suarez, Eizo Watanabe
No abstract text is available yet for this article.
June 13, 2018: Critical Care: the Official Journal of the Critical Care Forum
Soufiane Ghailane, Houssam Bouloussa, Vincent Challier, Claudio Vergari, Go Yoshida, Ibrahim Obeid, Louis Boissière, Jean-Marc Vital, Simon Mazas, Pierre Coudert, Olivier Gille
STUDY DESIGN: Inter- and intraobserver reliability study. OBJECT: To assess the reliability of a new radiographic classification of degenerative spondylolisthesis of the lumbar spine (DSLS). SUMMARY OF BACKGROUND DATA: DSLS is a common cause of chronic low back and leg pain in adults. To this date, there is no consensus for a comprehensive analysis of DSLS. The reliability of a new DSLS classification system based on sagittal alignment was assessed...
July 2018: Spine Deformity
Alexandre Joosten, Shalini Raj Lawrence, Alexandra Colesnicenco, Sean Coeckelenbergh, Jean Louis Vincent, Philippe Van der Linden, Maxime Cannesson, Joseph Rinehart
Advances in noninvasive hemodynamic monitoring systems allow delivery of goal-directed fluid therapy and could therefore be used in less-invasive surgical procedures. In this randomized controlled trial, we compared closed-loop-assisted goal-directed fluid therapy using a noninvasive cardiac output (Clearsight system) monitor (personalized approach) to a protocolized fluid therapy approach in 40 patients undergoing moderate-risk laparoscopic abdominal surgery. Cardiac output and stroke volume variations were not significantly different in both groups and remained within predefined target values >90% of the study time...
June 5, 2018: Anesthesia and Analgesia
Simon Garinet, Vincent Fihman, Hervé Jacquier, Stéphane Corvec, Alban Le Monnier, Thomas Guillard, Vincent Cattoir, Jean-Ralph Zahar, Paul-Louis Woerther, Etienne Carbonnelle, Alain Wargnier, Solen Kernéis, Philippe C Morand
OBJECTIVES: The Enterobacter cloacae complex (Ecc), routinely referred to as "E. cloacae" in clinical microbiology, encompasses several species with 12 genetic clusters and one sequence crowd that can be identified based on hsp60 sequencing. Little is known about the pathogenicity and distribution of resistance to antibiotics among the Ecc. METHODS AND RESULTS: In this prospective multicentre study, a total of 193 Ecc clinical isolates were collected from 10 academic hospitals distributed nationally across France and identified at the genetic cluster level on the basis of hsp60 sequencing...
May 26, 2018: Journal of Infection
Béatrice Romier, Corinne Ivaldi, Hervé Sartelet, Andrea Heinz, Christian E H Schmelzer, Roselyne Garnotel, Alexandre Guillot, Jessica Jonquet, Eric Bertin, Jean-Louis Guéant, Jean-Marc Alberto, Jean-Pierre Bronowicki, Johanne Amoyel, Thinhinane Hocine, Laurent Duca, Pascal Maurice, Amar Bennasroune, Laurent Martiny, Laurent Debelle, Vincent Durlach, Sébastien Blaise
Affecting more than 30% of the Western population, nonalcoholic fatty liver disease (NAFLD) is the most common liver disease and can lead to multiple complications, including nonalcoholic steatohepatitis (NASH), cancer, hypertension, and atherosclerosis. Insulin resistance and obesity are described as potential causes of NAFLD. However, we surmised that factors such as extracellular matrix remodeling of large blood vessels, skin, or lungs may also participate in the progression of liver diseases. We studied the effects of elastin-derived peptides (EDPs), biomarkers of aging, on NAFLD progression...
August 2018: Diabetes
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