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Jean-Louis Vincent

Violaine Dubois, Laura Laencina, Anouchka Bories, Vincent Le Moigne, Alexandre Pawlik, Jean-Louis Herrmann, Fabienne Girard-Misguich
What differentiates Mycobacterium abscessus from other saprophytic mycobacteria is the ability to resist phagocytosis by human macrophages and the ability to multiply inside such cells. These virulence traits render M. abscessus pathogenic, especially in vulnerable hosts with underlying structural lung disease, such as cystic fibrosis, bronchiectasis or tuberculosis. How patients become infected with M. abscessus remains unclear. Unlike many mycobacteria, M. abscessus is not found in the environment but might reside inside amoebae, environmental phagocytes that represent a potential reservoir for M...
September 27, 2018: Journal of Visualized Experiments: JoVE
Jean-Louis Vincent
No abstract text is available yet for this article.
October 12, 2018: Intensive Care Medicine
Charles-Antoine Guay, Louis-Vincent Morin-Thibault, Sebastien Bonnet, Yves Lacasse, Caroline Lambert, Jean-Christophe Lega, Steeve Provencher
BACKGROUND: Pulmonary hypertension (PH) due to left heart failure (HF) is the most common form of PH. However, treatment is unclear because there are conflicting results about safety and efficacy of PH-targeted therapies. OBJECTIVES: To assess the effects of PH-targeted therapy on exercise capacity in HF patients. METHODS: MEDLINE, EMBASE and the Cochrane Library were searched from January 1990 to July 2017 for randomized controlled trials comparing PH-targeted therapies to conventional therapy in HF...
2018: PloS One
Jean-Louis Vincent
No abstract text is available yet for this article.
October 10, 2018: Blood Purification
Violaine Dubois, Albertus Viljoen, Laura Laencina, Vincent Le Moigne, Audrey Bernut, Faustine Dubar, Mickaël Blaise, Jean-Louis Gaillard, Yann Guérardel, Laurent Kremer, Jean-Louis Herrmann, Fabienne Girard-Misguich
Mycobacterium abscessus is a peculiar rapid-growing Mycobacterium (RGM) capable of surviving within eukaryotic cells thanks to an arsenal of virulence genes also found in slow-growing mycobacteria (SGM), such as Mycobacterium tuberculosis A screen based on the intracellular survival in amoebae and macrophages (MΦ) of an M. abscessus transposon mutant library revealed the important role of MAB_0855, a yet uncharacterized Mycobacterial membrane protein Large (MmpL). Large-scale comparisons with SGM and RGM genomes uncovered MmpL12 proteins as putative orthologs of MAB_0855 and a locus-scale synteny between the MAB_0855 and Mycobacterium chelonae mmpL8 loci...
October 9, 2018: Proceedings of the National Academy of Sciences of the United States of America
Jean-Louis Vincent, Wasineenart Mongkolpun
PURPOSE OF REVIEW: Sepsis is a common condition in critically ill patients and associated with high morbidity and mortality. Sepsis is the result of infection by many potential pathogens, including Gram-negative bacteria. There are no specific antisepsis therapies and management relies largely on infection control and organ support, including hemodynamic stabilization. We discuss these key aspects and briefly mention potential immunomodulatory strategies. RECENT FINDINGS: New aspects of sepsis management include the realization that early treatment is important and that fluids and vasopressor agents should be administered simultaneously to insure rapid restoration of an adequate perfusion pressure to limit development and worsening of organ dysfunction...
October 6, 2018: Current Opinion in Infectious Diseases
Emiel Hendrik Post, Fuhong Su, Cláudia Righy Shinotsuka, Fabio Silvio Taccone, Jacques Creteur, Daniel De Backer, Jean-Louis Vincent
Evidence suggests that septic shock patients with chronic arterial hypertension may benefit from resuscitation targeted to achieve higher blood pressure values than other patients, possibly as a result of altered renal autoregulation. The effects of different vasopressor agents on renal autoregulation may be important in this context. We investigated the effects of arginine vasopressin (AVP) and norepinephrine (NE) on renal autoregulation in ovine septic shock. Sepsis was induced by fecal peritonitis. When shock developed (decrease in mean arterial pressure to <65 mmHg and no fluid-responsiveness), animals were randomized to receive NE or AVP in a crossover design...
September 27, 2018: Journal of Applied Physiology
Antonella Cotoia, Federico Franchi, Chiara De Fazio, Jean-Louis Vincent, Jacques Creteur, Fabio Silvio Taccone
BACKGROUND: Platelet variables, including platelet distribution width (PDW) and mean platelet volume (MPV), have been associated with outcome in critically ill patients. We evaluated these variables in patients after cardiac arrest (CA). METHODS: All adult CA patients admitted to the intensive care unit (ICU) over an 8-year period (2006-2014) and treated with targeted temperature management were included. We retrieved all data concerning CA characteristics as well as platelet count, PDW and MPV on the first 2 days of admission...
September 25, 2018: BMC Emergency Medicine
Jean-François Burle, Bernard Vincent, Romain Lachal, Bruno Louis, Claude Guérin
No abstract text is available yet for this article.
October 2018: Respiratory Care
David J Lederer, Scott C Bell, Richard D Branson, James D Chalmers, Rachel Marshall, David M Maslove, David E Ost, Naresh M Punjabi, Michael Schatz, Alan R Smyth, Paul W Stewart, Samy Suissa, Alex A Adjei, Cezmi A Akdis, Elie Azoulay, Jan Bakker, Zuhair K Ballas, Philip G Bardin, Esther Barreiro, Rinaldo Bellomo, Jonathan A Bernstein, Vito Brusasco, Timothy G Buchman, Sudhansu Chokroverty, Nancy A Collop, James D Crapo, Dominic A Fitzgerald, Lauren Hale, Nicholas Hart, Felix J Herth, Theodore J Iwashyna, Gisli Jenkins, Martin Kolb, Guy B Marks, Peter Mazzone, J Randall Moorman, Thomas M Murphy, Terry L Noah, Paul Reynolds, Dieter Riemann, Richard E Russell, Aziz Sheikh, Giovanni Sotgiu, Erik R Swenson, Rhonda Szczesniak, Ronald Szymusiak, Jean-Louis Teboul, Jean-Louis Vincent
No abstract text is available yet for this article.
September 19, 2018: Annals of the American Thoracic Society
Jean-Louis Vincent
No abstract text is available yet for this article.
October 2017: Lancet Child & Adolescent Health
Richard Moreau, Laure Elkrief, Christophe Bureau, Jean-Marc Perarnau, Thierry Thévenot, Faouzi Saliba, Alexandre Louvet, Pierre Nahon, Adrien Lannes, Rodolphe Anty, Sophie Hillaire, Blandine Pasquet, Violaine Ozenne, Marika Rudler, Isabelle Ollivier-Hourmand, Marie Angèle Robic, Louis d'Alteroche, Vincent Di Martino, Marie-Pierre Ripault, Arnaud Pauwels, Jean-Didier Grangé, Nicolas Carbonell, Jean-Pierre Bronowicki, Audrey Payancé, Pierre-Emmanuel Rautou, Dominique Valla, Nathalie Gault, Didier Lebrec
BACKGROUND & AIMS: There is debate over the effects of long-term oral fluoroquinolone therapy in patients with advanced cirrhosis. We performed a randomized controlled trial to evaluate the effects of long-term treatment with the fluoroquinolone norfloxacin on survival of patients with cirrhosis. METHODS: We performed a double-blind trial of 291 patients with Child-Pugh class C cirrhosis who had not received recent fluoroquinolone therapy; the study was performed at 18 clinical sites in France from April 2010 through November 2014...
August 22, 2018: Gastroenterology
Jean-Louis Vincent, Kenneth B Christopher, Anthony McLean
No abstract text is available yet for this article.
October 2018: Intensive Care Medicine
Duc Nam Nguyen, Luc Huyghens, Jose Parra, Johan Schiettecatte, Johan Smitz, Jean-Louis Vincent
The pathogenesis of delirium in critically ill patients is multifactorial. How hypotension and hypoxemia affect brain function and whether they can promote delirium remains unclear. A high cumulative positive fluid balance may also have a negative effect on brain function and promote delirium. We hypothesized that delirium would be more likely to develop in patients with low systemic arterial pressure, hypoxemia and a higher positive fluid balance, and investigated these associations in a prospective observational cohort study in patients with shock...
2018: PloS One
Esther Peters, Massimo Antonelli, Xavier Wittebole, Rahul Nanchal, Bruno François, Yasser Sakr, Jean-Louis Vincent, Peter Pickkers
BACKGROUND: Acute kidney injury (AKI) is a common complication of critical illness and is associated with worse outcomes. However, the influence of deterioration or improvement in renal function on clinical outcomes is unclear. Using a large international database, we evaluated the prevalence and evolution of AKI over a 7-day period and its effects on clinical outcomes in septic and non-septic critically ill patients worldwide. METHODS: From the 10,069 adult intensive care unit (ICU) patients in the Intensive Care Over Nations database, all those with creatinine and urine output data were included in this substudy...
August 3, 2018: Critical Care: the Official Journal of the Critical Care Forum
Mathilde Nativel, Fabrice Schneider, Pierre-Jean Saulnier, Elise Gand, Stéphanie Ragot, Olivier Meilhac, Philippe Rondeau, Elena Burillo, Maxime Cournot, Louis Potier, Gilberto Velho, Michel Marre, Ronan Roussel, Vincent Rigalleau, Kamel Mohammedi, Samy Hadjadj
OBJECTIVE: Inflammation and oxidative stress play an important role in the pathogenesis of lower-extremity artery disease (LEAD). We assessed the prognostic values of inflammatory and redox status biomarkers on the risk of LEAD in individuals with type 2 diabetes. RESEARCH DESIGN AND METHODS: Plasma concentrations of tumor necrosis factor-α receptor 1 (TNFR1), angiopoietin-like 2, ischemia-modified albumin (IMA), fluorescent advanced glycation end products, protein carbonyls, and total reductive capacity of plasma were measured at baseline in the SURDIAGENE (Survie, Diabete de type 2 et Genetique) cohort...
October 2018: Diabetes Care
Laurent Opsomer, Vincent Théate, Philippe Lefèvre, Jean-Louis Thonnard
Predicting the consequences of one's own movements can be challenging when confronted with completely novel environmental dynamics, such as microgravity in space. The absence of gravitational force disrupts internal models of the central nervous system (CNS) that have been tuned to the dynamics of a constant 1- g environment since birth. In the context of object manipulation, inadequate internal models produce prediction uncertainty evidenced by increases in the grip force (GF) safety margin that ensures a stable grip during unpredicted load perturbations...
2018: Frontiers in Physiology
Luc Cabel, Emmanuelle Jeannot, Ivan Bieche, Sophie Vacher, Celine Callens, Louis Bazire, Adeline Morel, Alice Bernard-Tessier, Walid Chemlali, Anne Schnitzler, Astrid Lièvre, Joelle Otz, Mathieu Minsat, Anne Vincent-Salomon, Jean-Yves Pierga, Bruno Buecher, Pascale Mariani, Charlotte Proudhon, François-Clément Bidard, Wulfran Cacheux
Purpose: Chemoradiotherapy (CRT) is the current standard of care for patients diagnosed with locally advanced anal squamous cell carcinoma (ASCC), but some patients develop local and/or distant relapse during follow-up. This study was designed to monitor human papillomavirus (HPV) circulating tumor DNA (ctDNA) levels during CRT in patients with ASCC. Experimental Design: We analyzed samples from patients with HPV16- or HPV18-positive locally advanced ASCC. Blood samples were collected before and after CRT. HPV16 or HPV18 ctDNA detection was performed by droplet digital-PCR...
July 27, 2018: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
Clarisse Joachim, Jacqueline Veronique-Baudin, Thierry Almont, Stephen Ulric-Gervaise, Jonathan Macni, Olivier Pierre-Louis, Lidvine Godaert, Moustapha Drame, Jean-Luc Novella, Karim Farid, Vincent Vinh-Hung, Patrick Escarmant
PURPOSE: Recording cancer data in cancer registries is essential for producing reliable population-based data for service planning, monitoring and evaluation. Prostate cancer (PCa) remains the most frequent type of cancer in terms of incidence and mortality in men in the Caribbean. The quality of life PCa cohort will assess quality of life and patient outcomes in Martinique using a digital platform for patient-reported outcome measures. PARTICIPANTS: The Martinique Cancer Registry database is the largest clinical database among the French population-based cancer registries in the Caribbean, including more than 38 000 cancer cases, with 1650 new cancer cases per year, including 550 new PCa cases per year (2010-2014 latest period)...
July 25, 2018: BMJ Open
Faeq Husain-Syed, Zaccaria Ricci, Daniel Brodie, Jean-Louis Vincent, V Marco Ranieri, Arthur S Slutsky, Fabio Silvio Taccone, Luciano Gattinoni, Claudio Ronco
The complex nature of single organ failure potentially leading to multiple organ dysfunction syndrome (MODS) in critically ill patients necessitates integrated supportive therapy. Rather than a primary disease, acute kidney injury (AKI) is considered a window to a potentially serious underlying systemic disease, which may partially explain the high morbidity and mortality rates associated with the condition. Renal replacement therapy (RRT) has been routinely used for more than a decade in various intensive care settings and there has also been an increase in the use of extracorporeal membrane oxygenation and extracorporeal carbon dioxide removal...
September 2018: Intensive Care Medicine
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