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Jan Bakker

Leonhard A Bakker, Carin D Schröder, Lauriane A Spreij, Marianne Verhaegen, Joke De Vocht, Philip Van Damme, Jan H Veldink, Johanna M A Visser-Meily, Leonard H van den Berg, Tanja C W Nijboer, Michael A van Es
BACKGROUND: The Edinburgh cognitive and behavioral ALS screen (ECAS) was developed specifically to detect cognitive and behavioral changes in patients with amyotrophic lateral sclerosis (ALS). Differences with regard to normative data of different (language) versions of neuropsychological tests such as the ECAS exist. OBJECTIVE: To derive norms for the Dutch version of the ECAS. METHOD: Normative data were derived from a large sample of 690 control subjects and cognitive profiles were compared between a matched sample of 428 patients with ALS and 428 control subjects...
October 12, 2018: Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration
Jasper van der Aart, Maqsood Yaqub, Esther J M Kooijman, Jaco Bakker, Jan A M Langermans, Robert C Schuit, Mark B M Hofman, Johannes A M Christiaans, Adriaan A Lammertsma, Albert D Windhorst, Bart N M van Berckel
PURPOSE: There are currently no positron emission tomography (PET) radiotracers for the GluN2B (NR2B) binding sites of brain N-methyl-D-aspartate (NMDA) receptors. In rats, the GluN2B antagonist Ro25-6981 reduced the binding of N-((5-(4-fluoro-2-[11 C]methoxyphenyl)pyridin-3-yl)methyl)cyclopentanamin ([11 C]HACH242). This paper reports the evaluation of [11 C]HACH242 PET in non-human primates at baseline and following administration of the GluN2B negative allosteric modulator radiprodil...
October 10, 2018: Molecular Imaging and Biology: MIB: the Official Publication of the Academy of Molecular Imaging
Jaco Bakker, Annet L Louwerse, Edmond J Remarque, Jan A M Langermans
Common marmosets (Callithrix jacchus) demonstrate variations in reproductive output, not only in terms of total reproductive output during a lifetime but also in litter size per parturition. The present study explores factors, such as parents' litter size, parturition number, maternal body weight at conception and maternal age, which may account for this variation. A retrospective analysis of clinical records of a captive breeding colony was conducted over a 9-year period yielding reproductive summaries of 26 dams and 22 sires producing a total of 115 litters...
October 10, 2018: American Journal of Primatology
Juliet Mubaiwa, Vincenzo Fogliano, Cathrine Chidewe, Evert Jan Bakker, Anita R Linnemann
Bambara groundnut (Vigna subterranea (L.) Verdc.) is an indigenous legume crop, cultivated by subsistence farmers throughout sub-Saharan countries. Research findings indicate that the crop has great nutritional and agronomic potential, but it remains scientifically neglected. A baseline study was conducted in seven districts in semi-arid regions of rural Zimbabwe to gather knowledge on current production and utilization of bambara groundnut, assess its role in providing sustainable food and nutrition security for rural populations and determine priorities for follow-up research...
2018: PloS One
Britt M Blokker, Annick C Weustink, Ivo M Wagensveld, Jan H von der Thüsen, Andrea Pezzato, Ruben Dammers, Jan Bakker, Nomdo S Renken, Michael A den Bakker, Folkert J van Kemenade, Gabriel P Krestin, M G Myriam Hunink, J Wolter Oosterhuis
Purpose To compare the diagnostic performance of minimally invasive autopsy with that of conventional autopsy. Materials and Methods For this prospective, single-center, cross-sectional study in an academic hospital, 295 of 2197 adult cadavers (mean age: 65 years [range, 18-99 years]; age range of male cadavers: 18-99 years; age range of female cadavers: 18-98 years) who died from 2012 through 2014 underwent conventional autopsy. Family consent for minimally invasive autopsy was obtained for 139 of the 295 cadavers; 99 of those 139 cadavers were included in this study...
September 25, 2018: Radiology
Lynne Rumping, Federico Tessadori, Petra Jw Pouwels, Esmee Vringer, Jannie P Wijnen, Alex A Bhogal, Sanne Mc Savelberg, Karen J Duran, Mark Jg Bakkers, Rúben Jj Ramos, Peter Aw Schellekens, Hester Y Kroes, Dennis Wj Klomp, Graeme Cm Black, Rachel L Taylor, Jeroen Pw Bakkers, Hubertus Cmt Prinsen, Marjo S Knaap, Tobias B Dansen, Holger Rehmann, Fried Jt Zwartkruis, Roderick Hj Houwen, Gijs Haaften, Nanda M Verhoeven-Duif, Judith Jm Jans, Peter M Hasselt
Loss-of-function mutations in glutaminase (GLS), the enzyme converting glutamine into glutamate, and the counteracting enzyme glutamine synthetase (GS) cause disturbed glutamate homeostasis and severe neonatal encephalopathy. We report a de novo Ser482Cys gain-of-function variant in GLS encoding glutaminase associated with profound developmental delay and infantile cataract. Functional analysis demonstrated that this variant causes hyperactivity and compensatory downregulation of GLS expression combined with upregulation of the counteracting enzyme GS, supporting pathogenicity...
September 18, 2018: Human Molecular Genetics
David J Lederer, Scott C Bell, Richard D Branson, James D Chalmers, Rachel Marshall, David M Maslove, David E Ost, Naresh M Punjabi, Michael Schatz, Alan R Smyth, Paul W Stewart, Samy Suissa, Alex A Adjei, Cezmi A Akdis, Elie Azoulay, Jan Bakker, Zuhair K Ballas, Philip G Bardin, Esther Barreiro, Rinaldo Bellomo, Jonathan A Bernstein, Vito Brusasco, Timothy G Buchman, Sudhansu Chokroverty, Nancy A Collop, James D Crapo, Dominic A Fitzgerald, Lauren Hale, Nicholas Hart, Felix J Herth, Theodore J Iwashyna, Gisli Jenkins, Martin Kolb, Guy B Marks, Peter Mazzone, J Randall Moorman, Thomas M Murphy, Terry L Noah, Paul Reynolds, Dieter Riemann, Richard E Russell, Aziz Sheikh, Giovanni Sotgiu, Erik R Swenson, Rhonda Szczesniak, Ronald Szymusiak, Jean-Louis Teboul, Jean-Louis Vincent
No abstract text is available yet for this article.
September 19, 2018: Annals of the American Thoracic Society
Erik J Slootweg, Laurentiu N Spiridon, Eliza C Martin, Wladimir I Tameling, Philip D Townsend, Rikus Pomp, Jan Roosien, Olga Drawska, Octavina C A Sukarta, Arjen Schots, Jan Willem Borst, Matthieu H A J Joosten, Jaap Bakker, Geert Smant, Martin J Cann, Andrei Petrescu, Aska Goverse
The intracellular immune receptor Rx1 of potato (Solanum tuberosum), which confers effector-triggered immunity to Potato virus X, consists of a central nucleotide-binding domain (NB-ARC) flanked by a C-terminal Leucine-Rich Repeat (LRR) domain and an N-terminal coiled-coil (CC) domain. Rx1 activity is strictly regulated by interdomain interactions between the NB-ARC and LRR, but the contribution of the CC domain in regulating Rx1 activity or immune signaling is not fully understood. Therefore, we used a structure-informed approach to investigate the role of the CC domain in Rx1 functionality...
September 7, 2018: Plant Physiology
Suzette M Matthijsse, Steffie K Naber, Jan A C Hontelez, Roel Bakker, Marjolein van Ballegooijen, Iris Lansdorp-Vogelaar, Inge M C M de Kok, Harry J de Koning, Joost van Rosmalen, Sake J de Vlas
BACKGROUND: Human papillomavirus (HPV) vaccination and the implementation of primary HPV screening in the Netherlands will lead to a lower cervical disease burden. For evaluation and further improvement of prevention, it is important to estimate the magnitude and timing of health benefits of current and alternative vaccination strategies such as vaccination of boys or adults. METHODS AND FINDINGS: We evaluated the impact of the current girls-only vaccination program and alternative strategies on cervical disease burden among the first four vaccinated five-year birth cohorts, given the context of primary HPV screening...
2018: PloS One
Ivo M van Dongen, Maarten Z H Kolk, Joëlle Elias, Veronique M F Meijborg, Ruben Coronel, Jacques M T de Bakker, Bimmer E P M Claessen, Ronak Delewi, Dagmar M Ouweneel, Esther M Scheunhage, René J van der Schaaf, Maarten-Jan Suttorp, Matthijs Bax, Koen M Marques, Pieter G Postema, Arthur A M Wilde, José P S Henriques
INTRODUCTION: Chronic total coronary occlusions (CTOs) have been associated with a higher prevalence of ventricular arrhythmias compared to patients without a CTO. We evaluated the effect of CTO revascularization on electrocardiographic (ECG) variables. METHODS: We studied a selection of ST-elevation myocardial infarction patients with a concomitant CTO enrolled in the EXPLORE trial. ECG variables and cardiac function were analysed at baseline and at 4 months follow-up...
September 2018: Journal of Electrocardiology
Foram N Ashar, Rebecca N Mitchell, Christine M Albert, Christopher Newton-Cheh, Jennifer A Brody, Martina Müller-Nurasyid, Anna Moes, Thomas Meitinger, Angel Mak, Heikki Huikuri, M Juhani Junttila, Philippe Goyette, Sara L Pulit, Raha Pazoki, Michael W Tanck, Marieke T Blom, XiaoQing Zhao, Aki S Havulinna, Reza Jabbari, Charlotte Glinge, Vinicius Tragante, Stefan A Escher, Aravinda Chakravarti, Georg Ehret, Josef Coresh, Man Li, Ronald J Prineas, Oscar H Franco, Pui-Yan Kwok, Thomas Lumley, Florence Dumas, Barbara McKnight, Jerome I Rotter, Rozenn N Lemaitre, Susan R Heckbert, Christopher J O'Donnell, Shih-Jen Hwang, Jean-Claude Tardif, Martin VanDenburgh, André G Uitterlinden, Albert Hofman, Bruno H C Stricker, Paul I W de Bakker, Paul W Franks, Jan-Hakan Jansson, Folkert W Asselbergs, Marc K Halushka, Joseph J Maleszewski, Jacob Tfelt-Hansen, Thomas Engstrøm, Veikko Salomaa, Renu Virmani, Frank Kolodgie, Arthur A M Wilde, Hanno L Tan, Connie R Bezzina, Mark Eijgelsheim, John D Rioux, Xavier Jouven, Stefan Kääb, Bruce M Psaty, David S Siscovick, Dan E Arking, Nona Sotoodehnia
Aims: Sudden cardiac arrest (SCA) accounts for 10% of adult mortality in Western populations. We aim to identify potential loci associated with SCA and to identify risk factors causally associated with SCA. Methods and results: We carried out a large genome-wide association study (GWAS) for SCA (n = 3939 cases, 25 989 non-cases) to examine common variation genome-wide and in candidate arrhythmia genes. We also exploited Mendelian randomization (MR) methods using cross-trait multi-variant genetic risk score associations (GRSA) to assess causal relationships of 18 risk factors with SCA...
August 28, 2018: European Heart Journal
Emily J Meyer, Marni A Nenke, Wayne Rankin, John G Lewis, Elisabeth Konings, Maarten Slager, Tim C Jansen, Jan Bakker, Johannes Hofland, Richard A Feelders, David J Torpy
CONTEXT: Corticosteroid-binding globulin (CBG) and albumin transport circulating cortisol. Cleavage of high-affinity CBG (haCBG) by neutrophil elastase at inflammatory sites causes cortisol release into tissues, facilitating immunomodulatory effects. OBJECTIVE: To determine whether depletion of haCBG is related to mortality in septic shock. DESIGN: A single-center prospective observational cohort study of patients recruited with critical illness or septic shock, using serum samples collected at 0, 8, 24, 48 and 72 hours...
August 30, 2018: Clinical Endocrinology
Eva E Vink, Elie Azoulay, Arthur Caplan, Erwin J O Kompanje, Jan Bakker
In critically ill patients, it is frequently challenging to identify who will benefit from admission to the intensive care unit and life-sustaining interventions when the chances of a meaningful outcome are unclear. In addition, the acute illness not only affects the patients but also family members or surrogates who often are overwhelmed and unable to make thoughtful decisions. In these circumstances, a time-limited trial (TLT) of intensive care treatment can be helpful. A TLT is an agreement to initiate all necessary treatments or treatments with clearly delineated limitations for a certain period of time to gain a more realistic understanding of the patient's chances of a meaningful recovery or to ascertain the patient's wishes and values...
September 2018: Intensive Care Medicine
Marit S van Sandwijk, Aiko P J de Vries, Stephan J L Bakker, Ineke J M Ten Berge, Stefan P Berger, Yassine R Bouatou, Johan W de Fijter, Sandrine Florquin, Jaap J Homan van der Heide, Mirza M Idu, Christina Krikke, Karlijn A M I van der Pant, Marlies E Reinders, Jan Ringers, Neelke C van der Weerd, Frederike J Bemelman, Jan-Stephan S Sanders
BACKGROUND: The optimal immunosuppressive regimen in kidney transplant recipients, delivering maximum efficacy with minimal toxicity, is unknown. METHODS: The Amsterdam, LEiden, GROningen trial is a randomized, multicenter, investigator-driven, noninferiority, open-label trial in 305 kidney transplant recipients, in which 2 immunosuppression minimization strategies-one consisting of early steroid withdrawal, the other of tacrolimus minimization 6 months after transplantation-were compared with standard immunosuppression with basiliximab, corticosteroids, tacrolimus, and mycophenolic acid...
June 2018: Transplantation Direct
Floris F van den Brand, Carin M J van Nieuwkerk, Bart J Verwer, Ynto S de Boer, Nanne K H de Boer, Chris J J Mulder, Elisabeth Bloemena, Christine M Bakker, Jan M Vrolijk, Joost P H Drenth, Adriaan C I T L Tan, Frank Ter Borg, Martijn J Ter Borg, Sven J van den Hazel, Akin Inderson, Maarten E Tushuizen, Gerd Bouma
BACKGROUND: Azathioprine (AZA) and mercaptopurine (MP) are the cornerstone of steroid-sparing strategies in autoimmune hepatitis (AIH). Up to 20% of patients do not tolerate or respond to these regimens. AIM: To evaluate retrospectively the tolerability and efficacy of tioguanine (thioguanine) (TG) therapy in selected patients with AIH and AIH variant syndromes. METHODS: Records of 52 patients who received TG therapy were retrieved from nine hospitals in the Netherlands...
October 2018: Alimentary Pharmacology & Therapeutics
Marja van Dijk, Arie M van Roon, M Yusof Said, Frederike J Bemelman, Jaap J Homan van der Heide, Hans W de Fijter, Aiko P J de Vries, Stephan J L Bakker, Jan Stephan F Sanders
Long-term data on cardiovascular (CV) outcome of renal transplant recipients (RTR) on mTOR-i (mammalian Target Of Rapamycin-inhibitors) are scarce. In a sub-study of the MECANO trial we investigated changes in intima media thickness (IMT), CV risk profile, Major Adverse CV Events (MACE) and survival in RTR on a mTORi versus CNI based regimen. Patients (enrolled 361) were treated with (basiliximab) and triple IS (CsA-Cyclosporine A-(C), MPS (M), prednisolone (P)). At M6 patients were randomized (n = 224) to the CsA group (C, P, N = 89), MPS group (M, P, N = 39) EVL group (Everolimus, P, N = 96)...
August 14, 2018: Transplant International: Official Journal of the European Society for Organ Transplantation
Marco van Londen, Nicolien Kasper, Niek R Hessels, A Lianne Messchendorp, Stephan J L Bakker, Jan-Stephan F Sanders, Stefan P Berger, Martin H de Borst, Gerjan Navis
Compensatory GFR increase after kidney donation results in a GFR above 50% of the pre-donation value. The Renal Functional Reserve assessed by the renal response to dopamine infusion (RFRdopa ) is considered to reflect functional reserve capacity and thought to be a tool for living donor screening. However, it is unknown if the RFRdopa predicts long-term kidney function. Between 1984 and 2017, we prospectively measured mGFR (125- I-Iothalamate) and RFR by dopamine infusion in 937 living kidney donors. We performed linear regression analysis of pre-donation RFRdopa and post-donation GFR...
August 8, 2018: American Journal of Physiology. Renal Physiology
Bálint S de Vries, Laura M M Rustemeijer, Leonhard A Bakker, Carin D Schröder, Jan H Veldink, Leonard H van den Berg, Tanja C W Nijboer, Michael A van Es
OBJECTIVES: Cognitive and behavioural changes within the spectrum of frontotemporal dementia (FTD) are observed frequently in patients with amyotrophic lateral sclerosis (ALS). Whether these changes also occur in other forms of motor neuron disease (MND) is not well studied. We therefore systemically screened a large cohort of patients with primary lateral sclerosis (PLS) and progressive muscular atrophy (PMA) for cognitive and behavioural changes, and subsequently compared our findings with a cohort of patients with ALS...
August 3, 2018: Journal of Neurology, Neurosurgery, and Psychiatry
Elena Rampanelli, Peter Ochodnicky, Johannes P C Vissers, Loes M Butter, Nike Claessen, Alessia Calcagni, Lotte Kors, Lee A Gethings, Stephan J L Bakker, Martin H de Borst, Gerjan J Navis, Gerhard Liebisch, Dave Speijer, Marius A van den Bergh Weerman, Bettina Jung, Jan Aten, Eric Steenbergen, Gerd Schmitz, Andrea Ballabio, Sandrine Florquin, Johannes M F G Aerts, Jaklien C Leemans
Obesity and dyslipidaemia are features of the metabolic syndrome and risk factors for chronic kidney disease. The cellular mechanisms connecting metabolic syndrome with chronic kidney disease onset and progression remain largely unclear. We show that proximal tubular epithelium is a target site for lipid deposition upon overnutrition with a cholesterol-rich Western-type diet. Affected proximal tubule epithelial cells displayed giant vacuoles of lysosomal or autophagosomal origin, harbouring oxidized lipoproteins and concentric membrane layer structures (multilamellar bodies), reminiscent of lysosomal storage diseases; lipidomic analysis revealed renal deposition of cholesterol and phospholipids, including lysosomal phospholipids...
August 2, 2018: Journal of Pathology
Rosa L Schellevis, Elon H C van Dijk, Myrte B Breukink, Lebriz Altay, Bjorn Bakker, Bobby P C Koeleman, Lambertus A Kiemeney, Dorine W Swinkels, Jan E E Keunen, Sascha Fauser, Carel B Hoyng, Anneke I den Hollander, Camiel J F Boon, Eiko K de Jong
Importance: To date, several targeted genetic studies on chronic central serous chorioretinopathy (cCSC) have been performed; however, unbiased genome-wide studies into the genetics of cCSC have not been reported. To discover new genetic loci associated with cCSC and to better understand the causative mechanism of this disease, we performed a genome-wide association study (GWAS) on patients with cCSC. Objective: To discover new genetic loci and pathways associated with cCSC and to predict the association of genetic variants with gene expression in patients with cCSC...
October 1, 2018: JAMA Ophthalmology
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