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Jan Bakker

Floris F van den Brand, Carin M J van Nieuwkerk, Bart J Verwer, Ynto S de Boer, Nanne K H de Boer, Chris J J Mulder, Elisabeth Bloemena, Christine M Bakker, Jan M Vrolijk, Joost P H Drenth, Adriaan C I T L Tan, Frank Ter Borg, Martijn J Ter Borg, Sven J van den Hazel, Akin Inderson, Maarten E Tushuizen, Gerd Bouma
BACKGROUND: Azathioprine (AZA) and mercaptopurine (MP) are the cornerstone of steroid-sparing strategies in autoimmune hepatitis (AIH). Up to 20% of patients do not tolerate or respond to these regimens. AIM: To retrospectively evaluate the tolerability and efficacy of tioguanine (thioguanine) (TG) therapy in selected patients with AIH and AIH variant syndromes. METHODS: Records of 52 patients who received TG therapy were retrieved from nine hospitals in the Netherlands...
August 15, 2018: Alimentary Pharmacology & Therapeutics
Marja van Dijk, Arie M van Roon, M Yusof Said, Frederike J Bemelman, Jaap J Homan van der Heide, Hans W de Fijter, Aiko P J de Vries, Stephan J L Bakker, Jan Stephan F Sanders
Long-term data on cardiovascular (CV) outcome of renal transplant recipients (RTR) on mTOR-i (mammalian Target Of Rapamycin-inhibitors) are scarce. In a sub-study of the MECANO trial we investigated changes in intima media thickness (IMT), CV risk profile, Major Adverse CV Events (MACE) and survival in RTR on a mTORi versus CNI based regimen. Patients (enrolled 361) were treated with (basiliximab) and triple IS (CsA-Cyclosporine A-(C), MPS(M), prednisolone(P)). At M6 patients were randomized (n=224) to the CsA group (C, P, N=89), MPS group (M, P, N=39) EVL group (Everolimus, P, N=96)...
August 14, 2018: Transplant International: Official Journal of the European Society for Organ Transplantation
Marco van Londen, Nicolien Kasper, Niek R Hessels, A Lianne Messchendorp, Stephan J L Bakker, Jan-Stephan F Sanders, Stefan P Berger, Martin H de Borst, Gerjan Navis
Compensatory GFR increase after kidney donation results in a GFR above 50% of the pre-donation value. The Renal Functional Reserve assessed by the renal response to dopamine infusion (RFRdopa ) is considered to reflect functional reserve capacity and thought to be a tool for living donor screening. However, it is unknown if the RFRdopa predicts long-term kidney function. Between 1984 and 2017, we prospectively measured mGFR (125- I-Iothalamate) and RFR by dopamine infusion in 937 living kidney donors. We performed linear regression analysis of pre-donation RFRdopa and post-donation GFR...
August 8, 2018: American Journal of Physiology. Renal Physiology
Bálint S de Vries, Laura M M Rustemeijer, Leonhard A Bakker, Carin D Schröder, Jan H Veldink, Leonard H van den Berg, Tanja C W Nijboer, Michael A van Es
OBJECTIVES: Cognitive and behavioural changes within the spectrum of frontotemporal dementia (FTD) are observed frequently in patients with amyotrophic lateral sclerosis (ALS). Whether these changes also occur in other forms of motor neuron disease (MND) is not well studied. We therefore systemically screened a large cohort of patients with primary lateral sclerosis (PLS) and progressive muscular atrophy (PMA) for cognitive and behavioural changes, and subsequently compared our findings with a cohort of patients with ALS...
August 3, 2018: Journal of Neurology, Neurosurgery, and Psychiatry
Elena Rampanelli, Peter Ochodnicky, Johannes P C Vissers, Loes M Butter, Nike Claessen, Alessia Calcagni, Lotte Kors, Lee A Gethings, Stephan J L Bakker, Martin H de Borst, Gerjan J Navis, Gerhard Liebisch, Dave Speijer, Marius A van den Bergh Weerman, Bettina Jung, Jan Aten, Eric Steenbergen, Gerd Schmitz, Andrea Ballabio, Sandrine Florquin, Johannes M F G Aerts, Jaklien C Leemans
Obesity and dyslipidaemia are features of the metabolic syndrome and risk factors for chronic kidney disease. The cellular mechanisms connecting metabolic syndrome with chronic kidney disease onset and progression remain largely unclear. We show that proximal tubular epithelium is a target site for lipid deposition upon overnutrition with a cholesterol-rich Western-type diet. Affected proximal tubule epithelial cells displayed giant vacuoles of lysosomal or autophagosomal origin, harbouring oxidized lipoproteins and concentric membrane layer structures (multilamellar bodies), reminiscent of lysosomal storage diseases; lipidomic analysis revealed renal deposition of cholesterol and phospholipids, including lysosomal phospholipids...
August 2, 2018: Journal of Pathology
Rosa L Schellevis, Elon H C van Dijk, Myrte B Breukink, Lebriz Altay, Bjorn Bakker, Bobby P C Koeleman, Lambertus A Kiemeney, Dorine W Swinkels, Jan E E Keunen, Sascha Fauser, Carel B Hoyng, Anneke I den Hollander, Camiel J F Boon, Eiko K de Jong
Importance: To date, several targeted genetic studies on chronic central serous chorioretinopathy (cCSC) have been performed; however, unbiased genome-wide studies into the genetics of cCSC have not been reported. To discover new genetic loci associated with cCSC and to better understand the causative mechanism of this disease, we performed a genome-wide association study (GWAS) on patients with cCSC. Objective: To discover new genetic loci and pathways associated with cCSC and to predict the association of genetic variants with gene expression in patients with cCSC...
August 2, 2018: JAMA Ophthalmology
Oleg Selig, Ana V Cunha, Mark B van Eldijk, Jan C M van Hest, Thomas L C Jansen, Huib J Bakker, Yves L A Rezus
Elastin-like peptides are hydrophobic biopolymers that exhibit a reversible coacervation transition when the temperature is raised above a critical point. Here, we use a combination of linear infrared spectroscopy, two-dimensional infrared spectroscopy, and molecular dynamics simulations to study the structural dynamics of two elastin-like peptides. Specifically, we investigate the effect of the solvent environment and temperature on the structural dynamics of a short (5-residue) elastin-like peptide and of a long (450-residue) elastin-like peptide...
August 16, 2018: Journal of Physical Chemistry. B
Glenn Hernández, Alexandre Biasi Cavalcanti, Gustavo Ospina-Tascón, Arnaldo Dubin, Francisco Javier Hurtado, Lucas Petri Damiani, Gilberto Friedman, Ricardo Castro, Leyla Alegría, Maurizio Cecconi, Jean-Louis Teboul, Jan Bakker
BACKGROUND: ANDROMEDA-SHOCK is an international, multicenter, randomized controlled trial comparing peripheral perfusion-targeted resuscitation to lactate-targeted resuscitation in patients with septic shock in order to test the hypothesis that resuscitation targeting peripheral perfusion will be associated with lower morbidity and mortality. OBJECTIVE: To report the statistical analysis plan for the ANDROMEDA-SHOCK trial. METHODS: We describe the trial design, primary and secondary objectives, patients, methods of randomization, interventions, outcomes, and sample size...
July 30, 2018: Revista Brasileira de Terapia Intensiva
Yuehan Dou, Lin Zhen, Xiubo Yu, Martha Bakker, Gerrit-Jan Carsjens, Zhichao Xue
Landscape change caused by ecological restoration projects has both positive and negative influences on human livelihoods, yet surprisingly little research on the cultural consequences of ecological restoration in agricultural landscapes has taken place. Cultural consequences can be captured in the ecosystem services framework as cultural ecosystem services (CES). However, assessment and valuation of these services to support decision-making for this essential ecosystem is lacking. To help fill this gap, we assessed the opinions of Chinese rural communities about CES and the changes in their perception under the Grain for Green program (GFG), a nationwide program to relieve the pressure on ecosystems (soil erosion and land degradation) by converting cultivated land or barren land on steep slopes into grassland and forests...
July 27, 2018: Science of the Total Environment
Jessica van Setten, Jennifer A Brody, Yalda Jamshidi, Brenton R Swenson, Anne M Butler, Harry Campbell, Fabiola M Del Greco, Daniel S Evans, Quince Gibson, Daniel F Gudbjartsson, Kathleen F Kerr, Bouwe P Krijthe, Leo-Pekka Lyytikäinen, Christian Müller, Martina Müller-Nurasyid, Ilja M Nolte, Sandosh Padmanabhan, Marylyn D Ritchie, Antonietta Robino, Albert V Smith, Maristella Steri, Toshiko Tanaka, Alexander Teumer, Stella Trompet, Sheila Ulivi, Niek Verweij, Xiaoyan Yin, David O Arnar, Folkert W Asselbergs, Joel S Bader, John Barnard, Josh Bis, Stefan Blankenberg, Eric Boerwinkle, Yuki Bradford, Brendan M Buckley, Mina K Chung, Dana Crawford, Marcel den Hoed, Josh C Denny, Anna F Dominiczak, Georg B Ehret, Mark Eijgelsheim, Patrick T Ellinor, Stephan B Felix, Oscar H Franco, Lude Franke, Tamara B Harris, Hilma Holm, Gandin Ilaria, Annamaria Iorio, Mika Kähönen, Ivana Kolcic, Jan A Kors, Edward G Lakatta, Lenore J Launer, Honghuang Lin, Henry J Lin, Ruth J F Loos, Steven A Lubitz, Peter W Macfarlane, Jared W Magnani, Irene Mateo Leach, Thomas Meitinger, Braxton D Mitchell, Thomas Munzel, George J Papanicolaou, Annette Peters, Arne Pfeufer, Peter P Pramstaller, Olli T Raitakari, Jerome I Rotter, Igor Rudan, Nilesh J Samani, David Schlessinger, Claudia T Silva Aldana, Moritz F Sinner, Jonathan D Smith, Harold Snieder, Elsayed Z Soliman, Timothy D Spector, David J Stott, Konstantin Strauch, Kirill V Tarasov, Unnur Thorsteinsdottir, Andre G Uitterlinden, David R Van Wagoner, Uwe Völker, Henry Völzke, Melanie Waldenberger, Harm Jan Westra, Philipp S Wild, Tanja Zeller, Alvaro Alonso, Christy L Avery, Stefania Bandinelli, Emelia J Benjamin, Francesco Cucca, Marcus Dörr, Luigi Ferrucci, Paolo Gasparini, Vilmundur Gudnason, Caroline Hayward, Susan R Heckbert, Andrew A Hicks, J Wouter Jukema, Stefan Kääb, Terho Lehtimäki, Yongmei Liu, Patricia B Munroe, Afshin Parsa, Ozren Polasek, Bruce M Psaty, Dan M Roden, Renate B Schnabel, Gianfranco Sinagra, Kari Stefansson, Bruno H Stricker, Pim van der Harst, Cornelia M van Duijn, James F Wilson, Sina A Gharib, Paul I W de Bakker, Aaron Isaacs, Dan E Arking, Nona Sotoodehnia
Electrocardiographic PR interval measures atrio-ventricular depolarization and conduction, and abnormal PR interval is a risk factor for atrial fibrillation and heart block. Our genome-wide association study of over 92,000 European-descent individuals identifies 44 PR interval loci (34 novel). Examination of these loci reveals known and previously not-yet-reported biological processes involved in cardiac atrial electrical activity. Genes in these loci are over-represented in cardiac disease processes including heart block and atrial fibrillation...
July 25, 2018: Nature Communications
Jan Bakker
No abstract text is available yet for this article.
August 2018: Journal of Critical Care
Sietske M K Bakker, Maaike G E Fenten, Daan J Touw, Bart J F van den Bemt, Petra J C Heesterbeek, Gert-Jan Scheffer, Rudolf Stienstra
BACKGROUND AND OBJECTIVES: Local infiltration analgesia (LIA) with ropivacaine for total knee arthroplasty (TKA) is increasingly used. Despite the high doses of ropivacaine, LIA is considered safe, and this perception is sustained by pharmacokinetic data demonstrating that maximum concentrations of ropivacaine stay well below the toxic threshold in plasma. These pharmacokinetic studies all involve TKA procedures with the use of a tourniquet. Recently, performing TKA without the use of a tourniquet is gaining popularity, but no pharmacokinetic data exist when LIA is administered for TKA without the use of a tourniquet...
June 13, 2018: Regional Anesthesia and Pain Medicine
Joost C van den Born, Anne-Roos S Frenay, Anne M Koning, Matthias Bachtler, Ineke J Riphagen, Isidor Minovíc, Martin Feelisch, Marinda M Dekker, Marian L C Bulthuis, Ron T Gansevoort, Jan-Luuk Hillebrands, Andreas Pasch, Stephan J L Bakker, Harry van Goor
AIMS: Thiosulfate and sulfate are metabolites of hydrogen sulfide (H2 S), a gaseous signaling molecule with cardiovascular (CV) protective properties. Urinary thiosulfate excretion and sulfate excretion are associated with favorable disease outcome in high-risk patient groups. We investigated the relationship between urinary excretion of sulfur metabolites, and risk of CV events and all-cause mortality in the general population. RESULTS: Subjects (n = 6839) of the Prevention of Renal and Vascular End-stage Disease (PREVEND) study were followed prospectively...
July 25, 2018: Antioxidants & Redox Signaling
Friso Kortlandt, Juliette Velu, Remco Schurer, Tom Hendriks, Ben Van den Branden, Berto Bouma, Ted Feldman, Johannes Kelder, Annelies Bakker, Marco Post, Pim Van der Harst, Frank Eefting, Martin Swaans, Benno Rensing, Jan Baan, Jan Van der Heyden
BACKGROUND: Survival outcome after MitraClip treatment, compared with surgical or conservative treatment, is not well defined. We examined survival after MitraClip treatment in a large multicenter real-life setting. METHODS AND RESULTS: We retrospectively formed matched high-risk surgically and conservatively treated control cohorts to compare to a high-risk MitraClip cohort. One thousand thirty-six patients were included in 4 Dutch centers, of which 568 were treated with the MitraClip...
June 2018: Circulation. Cardiovascular Interventions
Natalia Teixeira, Marian J Mourits, Jan C Oosterwijk, Ingrid E Fakkert, Anthony R Absalom, Stephan J L Bakker, Peter van der Meer, Geertruida H de Bock
This cross-sectional study aimed to investigate the effect of premenopausal risk reducing salpingo-oophorectomy (RRSO) on the cholesterol profile of women at increased ovarian cancer risk and to assess possible effects of age at and time since RRSO. We included 207 women who underwent RRSO before menopausal age (52 years) attending the family cancer clinic of an academic hospital and 828 age-matched women from a general population cohort (PREVEND). Participants filled out a questionnaire on socio-demographic characteristics, lifestyle and medical history, had anthropometric measurements and provided blood samples for assessment of serum levels of total cholesterol, HDL-cholesterol and non-HDL-cholesterol...
June 7, 2018: Familial Cancer
Chris Wymant, François Blanquart, Tanya Golubchik, Astrid Gall, Margreet Bakker, Daniela Bezemer, Nicholas J Croucher, Matthew Hall, Mariska Hillebregt, Swee Hoe Ong, Oliver Ratmann, Jan Albert, Norbert Bannert, Jacques Fellay, Katrien Fransen, Annabelle Gourlay, M Kate Grabowski, Barbara Gunsenheimer-Bartmeyer, Huldrych F Günthard, Pia Kivelä, Roger Kouyos, Oliver Laeyendecker, Kirsi Liitsola, Laurence Meyer, Kholoud Porter, Matti Ristola, Ard van Sighem, Ben Berkhout, Marion Cornelissen, Paul Kellam, Peter Reiss, Christophe Fraser
Studying the evolution of viruses and their molecular epidemiology relies on accurate viral sequence data, so that small differences between similar viruses can be meaningfully interpreted. Despite its higher throughput and more detailed minority variant data, next-generation sequencing has yet to be widely adopted for HIV. The difficulty of accurately reconstructing the consensus sequence of a quasispecies from reads (short fragments of DNA) in the presence of large between- and within-host diversity, including frequent indels, may have presented a barrier...
January 2018: Virus Evolution
Nele Vandersickel, Alexandre Bossu, Jan De Neve, Albert Dunnink, Veronique M F Meijborg, Marcel A G van der Heyden, Jet D M Beekman, Jacques M T De Bakker, Marc A Vos, Alexander V Panfilov
OBJECTIVES: This study investigated the arrhythmogenic mechanisms responsible for torsade de pointes (TdP) in the chronic atrioventricular block dog model, known for its high susceptibility for TdP. BACKGROUND: The mechanism of TdP arrhythmias has been under debate for many years. Focal activity as well as re-entry have both been mentioned in the initiation and the perpetuation of TdP. METHODS: In 5 TdP-sensitive chronic atrioventricular block dogs, 56 needle electrodes were evenly distributed transmurally to record 240 unipolar local electrograms simultaneously...
December 26, 2017: JACC. Clinical Electrophysiology
Glenn Hernandez, Rinaldo Bellomo, Jan Bakker
No abstract text is available yet for this article.
May 12, 2018: Intensive Care Medicine
Aurelia H M de Vries Schultink, Robert P Doornbos, Alexander B H Bakker, Kees Bol, Mark Throsby, Cecile Geuijen, David Maussang, Jan H M Schellens, Jos H Beijnen, Alwin D R Huitema
Introduction MCLA-128 is a bispecific monoclonal antibody targeting the HER2 and HER3 receptors. Pharmacokinetics (PK) and pharmacodynamics (PD) of MCLA-128 have been evaluated in preclinical studies in cynomolgus monkeys and mice. The aim of this study was to characterize the PK and PD of MCLA-128 and to predict a safe starting dose and efficacious clinical dose for the First-In-Human study. Methods A PK-PD model was developed based on PK data from cynomolgus monkeys and tumor growth data from a mouse JIMT-1 xenograft model...
May 5, 2018: Investigational New Drugs
Moritz V Warmbrunn, Bernadette S de Bakker, Jaco Hagoort, Pauline B Alefs-de Bakker, Roelof-Jan Oostra
Congenital muscle diseases, such as myopathies or dystrophies, occur relatively frequently, with estimated incidences of up to 4.7 per 100 000 newborns. To diagnose congenital diseases in the early stages of pregnancy, and to interpret the results of increasingly advanced in utero imaging techniques, a profound knowledge of normal human morphological development of the locomotor system and the nervous system is necessary. Muscular development, however, is an often neglected topic or is only described in a general way in embryology textbooks and papers...
August 2018: Journal of Anatomy
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