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Jan Bakker

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#1
EDITORIAL
Jan Bakker
No abstract text is available yet for this article.
February 2019: Journal of Critical Care
https://www.readbyqxmd.com/read/30478622/prognostic-relevance-of-serum-lactate-kinetics-in-critically-ill-patients
#2
Maryna Masyuk, Bernhard Wernly, Michael Lichtenauer, Marcus Franz, Bjoern Kabisch, Johanna M Muessig, Georg Zimmermann, Alexander Lauten, P Christian Schulze, Uta C Hoppe, Malte Kelm, Jan Bakker, Christian Jung
PURPOSE: Changes of lactate concentration over time were reported to be associated with survival in septic patients. We aimed to evaluate delta-lactate (ΔLac) 24 h after admission (Δ24Lac) to an intensive care unit (ICU) in critically ill patients for short- and long-term prognostic relevance. METHODS: In total, 26,285 lactate measurements of 2191 patients admitted to a German ICU were analyzed. Inclusion criterion was a lactate concentration at admission above 2...
November 26, 2018: Intensive Care Medicine
https://www.readbyqxmd.com/read/30465893/risk-indicators-for-acute-kidney-injury-in-cardiogenic-shock
#3
Johannes P C van den Akker, Jan Bakker, A B J Groeneveld, C A den Uil
PURPOSE: In critical illness, the relation between the macrocirculation, microcirculation and organ dysfunction, such as acute kidney injury (AKI), is complex. This study aimed at identifying predictors for AKI in patients with cardiogenic shock. MATERIALS AND METHODS: Thirty-nine adult cardiogenic shock patients, with an admission creatinine <200 μmol l-1 , and whose microcirculation was measured within 48 h were enrolled. Patient data were analyzed if AKI stage ≥1 developed according to the Kidney Disease/Improving Outcomes classification within 48 h after admission...
November 10, 2018: Journal of Critical Care
https://www.readbyqxmd.com/read/30456467/fluid-administration-for-acute-circulatory-dysfunction-using-basic-monitoring-narrative-review-and-expert-panel-recommendations-from-an-esicm-task-force
#4
Maurizio Cecconi, Glenn Hernandez, Martin Dunser, Massimo Antonelli, Tim Baker, Jan Bakker, Jacques Duranteaum, Sharon Einav, A B Johan Groeneveld, Tim Harris, Sameer Jog, Flavia R Machado, Mervyn Mer, M Ignacio Monge Garcia, Sheila Nainan Myatra, Anders Perner, Jean-Louis Teboul, Jean-Louis Vincent, Daniel De Backer
An international team of experts in the field of fluid resuscitation was invited by the ESICM to form a task force to systematically review the evidence concerning fluid administration using basic monitoring. The work included a particular emphasis on pre-ICU hospital settings and resource-limited settings. The work focused on four main questions: (1) What is the role of clinical assessment to guide fluid resuscitation in shock? (2) What basic monitoring is required to perform and interpret a fluid challenge? (3) What defines a fluid challenge in terms of fluid type, ranges of volume, and rate of administration? (4) What are the safety endpoints during a fluid challenge? The expert panel found insufficient evidence to provide recommendations according to the GRADE system, and was only able to make recommendations for basic interventions, based on the available evidence and expert opinion...
November 19, 2018: Intensive Care Medicine
https://www.readbyqxmd.com/read/30388399/genome-analyses-of-200-000-individuals-identify-58-loci-for-chronic-inflammation-and-highlight-pathways-that-link-inflammation-and-complex-disorders
#5
Symen Ligthart, Ahmad Vaez, Urmo Võsa, Maria G Stathopoulou, Paul S de Vries, Bram P Prins, Peter J Van der Most, Toshiko Tanaka, Elnaz Naderi, Lynda M Rose, Ying Wu, Robert Karlsson, Maja Barbalic, Honghuang Lin, René Pool, Gu Zhu, Aurélien Macé, Carlo Sidore, Stella Trompet, Massimo Mangino, Maria Sabater-Lleal, John P Kemp, Ali Abbasi, Tim Kacprowski, Niek Verweij, Albert V Smith, Tao Huang, Carola Marzi, Mary F Feitosa, Kurt K Lohman, Marcus E Kleber, Yuri Milaneschi, Christian Mueller, Mahmudul Huq, Efthymia Vlachopoulou, Leo-Pekka Lyytikäinen, Christopher Oldmeadow, Joris Deelen, Markus Perola, Jing Hua Zhao, Bjarke Feenstra, Marzyeh Amini, Jari Lahti, Katharina E Schraut, Myriam Fornage, Bhoom Suktitipat, Wei-Min Chen, Xiaohui Li, Teresa Nutile, Giovanni Malerba, Jian'an Luan, Tom Bak, Nicholas Schork, Fabiola Del Greco M, Elisabeth Thiering, Anubha Mahajan, Riccardo E Marioni, Evelin Mihailov, Joel Eriksson, Ayse Bilge Ozel, Weihua Zhang, Maria Nethander, Yu-Ching Cheng, Stella Aslibekyan, Wei Ang, Ilaria Gandin, Loïc Yengo, Laura Portas, Charles Kooperberg, Edith Hofer, Kumar B Rajan, Claudia Schurmann, Wouter den Hollander, Tarunveer S Ahluwalia, Jing Zhao, Harmen H M Draisma, Ian Ford, Nicholas Timpson, Alexander Teumer, Hongyan Huang, Simone Wahl, YongMei Liu, Jie Huang, Hae-Won Uh, Frank Geller, Peter K Joshi, Lisa R Yanek, Elisabetta Trabetti, Benjamin Lehne, Diego Vozzi, Marie Verbanck, Ginevra Biino, Yasaman Saba, Ingrid Meulenbelt, Jeff R O'Connell, Markku Laakso, Franco Giulianini, Patrik K E Magnusson, Christie M Ballantyne, Jouke Jan Hottenga, Grant W Montgomery, Fernando Rivadineira, Rico Rueedi, Maristella Steri, Karl-Heinz Herzig, David J Stott, Cristina Menni, Mattias Frånberg, Beate St Pourcain, Stephan B Felix, Tune H Pers, Stephan J L Bakker, Peter Kraft, Annette Peters, Dhananjay Vaidya, Graciela Delgado, Johannes H Smit, Vera Großmann, Juha Sinisalo, Ilkka Seppälä, Stephen R Williams, Elizabeth G Holliday, Matthijs Moed, Claudia Langenberg, Katri Räikkönen, Jingzhong Ding, Harry Campbell, Michele M Sale, Yii-Der I Chen, Alan L James, Daniela Ruggiero, Nicole Soranzo, Catharina A Hartman, Erin N Smith, Gerald S Berenson, Christian Fuchsberger, Dena Hernandez, Carla M T Tiesler, Vilmantas Giedraitis, David Liewald, Krista Fischer, Dan Mellström, Anders Larsson, Yunmei Wang, William R Scott, Matthias Lorentzon, John Beilby, Kathleen A Ryan, Craig E Pennell, Dragana Vuckovic, Beverly Balkau, Maria Pina Concas, Reinhold Schmidt, Carlos F Mendes de Leon, Erwin P Bottinger, Margreet Kloppenburg, Lavinia Paternoster, Michael Boehnke, A W Musk, Gonneke Willemsen, David M Evans, Pamela A F Madden, Mika Kähönen, Zoltán Kutalik, Magdalena Zoledziewska, Ville Karhunen, Stephen B Kritchevsky, Naveed Sattar, Genevieve Lachance, Robert Clarke, Tamara B Harris, Olli T Raitakari, John R Attia, Diana van Heemst, Eero Kajantie, Rossella Sorice, Giovanni Gambaro, Robert A Scott, Andrew A Hicks, Luigi Ferrucci, Marie Standl, Cecilia M Lindgren, John M Starr, Magnus Karlsson, Lars Lind, Jun Z Li, John C Chambers, Trevor A Mori, Eco J C N de Geus, Andrew C Heath, Nicholas G Martin, Juha Auvinen, Brendan M Buckley, Anton J M de Craen, Melanie Waldenberger, Konstantin Strauch, Thomas Meitinger, Rodney J Scott, Mark McEvoy, Marian Beekman, Cristina Bombieri, Paul M Ridker, Karen L Mohlke, Nancy L Pedersen, Alanna C Morrison, Dorret I Boomsma, John B Whitfield, David P Strachan, Albert Hofman, Peter Vollenweider, Francesco Cucca, Marjo-Riitta Jarvelin, J Wouter Jukema, Tim D Spector, Anders Hamsten, Tanja Zeller, André G Uitterlinden, Matthias Nauck, Vilmundur Gudnason, Lu Qi, Harald Grallert, Ingrid B Borecki, Jerome I Rotter, Winfried März, Philipp S Wild, Marja-Liisa Lokki, Michael Boyle, Veikko Salomaa, Mads Melbye, Johan G Eriksson, James F Wilson, Brenda W J H Penninx, Diane M Becker, Bradford B Worrall, Greg Gibson, Ronald M Krauss, Marina Ciullo, Gianluigi Zaza, Nicholas J Wareham, Albertine J Oldehinkel, Lyle J Palmer, Sarah S Murray, Peter P Pramstaller, Stefania Bandinelli, Joachim Heinrich, Erik Ingelsson, Ian J Deary, Reedik Mägi, Liesbeth Vandenput, Pim van der Harst, Karl C Desch, Jaspal S Kooner, Claes Ohlsson, Caroline Hayward, Terho Lehtimäki, Alan R Shuldiner, Donna K Arnett, Lawrence J Beilin, Antonietta Robino, Philippe Froguel, Mario Pirastu, Tine Jess, Wolfgang Koenig, Ruth J F Loos, Denis A Evans, Helena Schmidt, George Davey Smith, P Eline Slagboom, Gudny Eiriksdottir, Andrew P Morris, Bruce M Psaty, Russell P Tracy, Ilja M Nolte, Eric Boerwinkle, Sophie Visvikis-Siest, Alex P Reiner, Myron Gross, Joshua C Bis, Lude Franke, Oscar H Franco, Emelia J Benjamin, Daniel I Chasman, Josée Dupuis, Harold Snieder, Abbas Dehghan, Behrooz Z Alizadeh
C-reactive protein (CRP) is a sensitive biomarker of chronic low-grade inflammation and is associated with multiple complex diseases. The genetic determinants of chronic inflammation remain largely unknown, and the causal role of CRP in several clinical outcomes is debated. We performed two genome-wide association studies (GWASs), on HapMap and 1000 Genomes imputed data, of circulating amounts of CRP by using data from 88 studies comprising 204,402 European individuals. Additionally, we performed in silico functional analyses and Mendelian randomization analyses with several clinical outcomes...
November 1, 2018: American Journal of Human Genetics
https://www.readbyqxmd.com/read/30348572/hip-and-knee-section-prevention-antimicrobials-systemic-proceedings-of-international-consensus-on-orthopedic-infections
#6
Craig A Aboltins, Jan Erik Berdal, Francisco Casas, Pablo S Corona, Daniel Cuellar, Matteo Carlo Ferrari, Edward Hendershot, Wei Huang, Feng-Chih Kuo, Arthur Malkani, Francisco Reyes, Sergio Rudelli, Oleg Safir, Thorsten Seyler, Timothy L Tan, Robert Townsend, Ibrahim Tuncay, David Turner, Heinz Winkler, Marjan Wouthuyzen-Bakker, Adolph J Yates, Akos Zahar
No abstract text is available yet for this article.
October 19, 2018: Journal of Arthroplasty
https://www.readbyqxmd.com/read/30346967/the-development-of-the-human-notochord
#7
Karel de Bree, Bernadette S de Bakker, Roelof-Jan Oostra
The notochord is a major regulator of embryonic patterning in vertebrates and abnormal notochordal development is associated with a variety of birth defects in man. Proper knowledge of the development of the human notochord, therefore, is important to understand the pathogenesis of these birth defects. Textbook descriptions vary significantly and seem to be derived from both human and animal data whereas the lack of references hampers verification of the presented data. Therefore, a verifiable and comprehensive description of the development of the human notochord is needed...
2018: PloS One
https://www.readbyqxmd.com/read/30314420/derivation-of-norms-for-the-dutch-version-of-the-edinburgh-cognitive-and-behavioral-als-screen
#8
Leonhard A Bakker, Carin D Schröder, Lauriane A Spreij, Marianne Verhaegen, Joke De Vocht, Philip Van Damme, Jan H Veldink, Johanna M A Visser-Meily, Leonard H van den Berg, Tanja C W Nijboer, Michael A van Es
BACKGROUND: The Edinburgh cognitive and behavioral ALS screen (ECAS) was developed specifically to detect cognitive and behavioral changes in patients with amyotrophic lateral sclerosis (ALS). Differences with regard to normative data of different (language) versions of neuropsychological tests such as the ECAS exist. OBJECTIVE: To derive norms for the Dutch version of the ECAS. METHOD: Normative data were derived from a large sample of 690 control subjects and cognitive profiles were compared between a matched sample of 428 patients with ALS and 428 control subjects...
October 12, 2018: Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration
https://www.readbyqxmd.com/read/30306318/evaluation-of-the-novel-pet-tracer-11-c-hach242-for-imaging-the-glun2b-nmda-receptor-in-non-human-primates
#9
Jasper van der Aart, Maqsood Yaqub, Esther J M Kooijman, Jaco Bakker, Jan A M Langermans, Robert C Schuit, Mark B M Hofman, Johannes A M Christiaans, Adriaan A Lammertsma, Albert D Windhorst, Bart N M van Berckel
PURPOSE: There are currently no positron emission tomography (PET) radiotracers for the GluN2B (NR2B) binding sites of brain N-methyl-D-aspartate (NMDA) receptors. In rats, the GluN2B antagonist Ro25-6981 reduced the binding of N-((5-(4-fluoro-2-[11 C]methoxyphenyl)pyridin-3-yl)methyl)cyclopentanamin ([11 C]HACH242). This paper reports the evaluation of [11 C]HACH242 PET in non-human primates at baseline and following administration of the GluN2B negative allosteric modulator radiprodil...
October 10, 2018: Molecular Imaging and Biology: MIB: the Official Publication of the Academy of Molecular Imaging
https://www.readbyqxmd.com/read/30302782/defining-predictive-factors-for-reproductive-output-in-captive-common-marmosets-callithrix-jacchus
#10
Jaco Bakker, Annet L Louwerse, Edmond J Remarque, Jan A M Langermans
Common marmosets (Callithrix jacchus) demonstrate variations in reproductive output, not only in terms of total reproductive output during a lifetime but also in litter size per parturition. The present study explores factors, such as parents' litter size, parturition number, maternal body weight at conception and maternal age, which may account for this variation. A retrospective analysis of clinical records of a captive breeding colony was conducted over a 9-year period yielding reproductive summaries of 26 dams and 22 sires producing a total of 115 litters...
November 2018: American Journal of Primatology
https://www.readbyqxmd.com/read/30278086/utilization-of-bambara-groundnut-vigna-subterranea-l-verdc-for-sustainable-food-and-nutrition-security-in-semi-arid-regions-of-zimbabwe
#11
Juliet Mubaiwa, Vincenzo Fogliano, Cathrine Chidewe, Evert Jan Bakker, Anita R Linnemann
Bambara groundnut (Vigna subterranea (L.) Verdc.) is an indigenous legume crop, cultivated by subsistence farmers throughout sub-Saharan countries. Research findings indicate that the crop has great nutritional and agronomic potential, but it remains scientifically neglected. A baseline study was conducted in seven districts in semi-arid regions of rural Zimbabwe to gather knowledge on current production and utilization of bambara groundnut, assess its role in providing sustainable food and nutrition security for rural populations and determine priorities for follow-up research...
2018: PloS One
https://www.readbyqxmd.com/read/30251930/conventional-autopsy-versus-minimally-invasive-autopsy-with-postmortem-mri-ct-and-ct-guided-biopsy-comparison-of-diagnostic-performance
#12
Britt M Blokker, Annick C Weustink, Ivo M Wagensveld, Jan H von der Thüsen, Andrea Pezzato, Ruben Dammers, Jan Bakker, Nomdo S Renken, Michael A den Bakker, Folkert J van Kemenade, Gabriel P Krestin, M G Myriam Hunink, J Wolter Oosterhuis
Purpose To compare the diagnostic performance of minimally invasive autopsy with that of conventional autopsy. Materials and Methods For this prospective, single-center, cross-sectional study in an academic hospital, 295 of 2197 adult cadavers (mean age: 65 years [range, 18-99 years]; age range of male cadavers: 18-99 years; age range of female cadavers: 18-98 years) who died from 2012 through 2014 underwent conventional autopsy. Family consent for minimally invasive autopsy was obtained for 139 of the 295 cadavers; 99 of those 139 cadavers were included in this study...
December 2018: Radiology
https://www.readbyqxmd.com/read/30239721/gls-hyperactivity-causes-glutamate-excess-infantile-cataract-and-profound-developmental-delay
#13
Lynne Rumping, Federico Tessadori, Petra Jw Pouwels, Esmee Vringer, Jannie P Wijnen, Alex A Bhogal, Sanne Mc Savelberg, Karen J Duran, Mark Jg Bakkers, Rúben Jj Ramos, Peter Aw Schellekens, Hester Y Kroes, Dennis Wj Klomp, Graeme Cm Black, Rachel L Taylor, Jeroen Pw Bakkers, Hubertus Cmt Prinsen, Marjo S Knaap, Tobias B Dansen, Holger Rehmann, Fried Jt Zwartkruis, Roderick Hj Houwen, Gijs Haaften, Nanda M Verhoeven-Duif, Judith Jm Jans, Peter M Hasselt
Loss-of-function mutations in glutaminase (GLS), the enzyme converting glutamine into glutamate, and the counteracting enzyme glutamine synthetase (GS) cause disturbed glutamate homeostasis and severe neonatal encephalopathy. We report a de novo Ser482Cys gain-of-function variant in GLS encoding glutaminase associated with profound developmental delay and infantile cataract. Functional analysis demonstrated that this variant causes hyperactivity and compensatory downregulation of GLS expression combined with upregulation of the counteracting enzyme GS, supporting pathogenicity...
September 18, 2018: Human Molecular Genetics
https://www.readbyqxmd.com/read/30230362/control-of-confounding-and-reporting-of-results-in-causal-inference-studies-guidance-for-authors-from-editors-of-respiratory-sleep-and-critical-care-journals
#14
David J Lederer, Scott C Bell, Richard D Branson, James D Chalmers, Rachel Marshall, David M Maslove, David E Ost, Naresh M Punjabi, Michael Schatz, Alan R Smyth, Paul W Stewart, Samy Suissa, Alex A Adjei, Cezmi A Akdis, Elie Azoulay, Jan Bakker, Zuhair K Ballas, Philip G Bardin, Esther Barreiro, Rinaldo Bellomo, Jonathan A Bernstein, Vito Brusasco, Timothy G Buchman, Sudhansu Chokroverty, Nancy A Collop, James D Crapo, Dominic A Fitzgerald, Lauren Hale, Nicholas Hart, Felix J Herth, Theodore J Iwashyna, Gisli Jenkins, Martin Kolb, Guy B Marks, Peter Mazzone, J Randall Moorman, Thomas M Murphy, Terry L Noah, Paul Reynolds, Dieter Riemann, Richard E Russell, Aziz Sheikh, Giovanni Sotgiu, Erik R Swenson, Rhonda Szczesniak, Ronald Szymusiak, Jean-Louis Teboul, Jean-Louis Vincent
No abstract text is available yet for this article.
September 19, 2018: Annals of the American Thoracic Society
https://www.readbyqxmd.com/read/30194238/distinct-roles-of-non-overlapping-surface-regions-of-the-coiled-coil-domain-in-the-potato-immune-receptor-rx1
#15
Erik J Slootweg, Laurentiu N Spiridon, Eliza C Martin, Wladimir I L Tameling, Philip D Townsend, Rikus Pomp, Jan Roosien, Olga Drawska, Octavina C A Sukarta, Arjen Schots, Jan Willem Borst, Matthieu H A J Joosten, Jaap Bakker, Geert Smant, Martin J Cann, Andrei-Jose Petrescu, Aska Goverse
The intracellular immune receptor Rx1 of potato ( Solanum tuberosum ), which confers effector-triggered immunity to Potato virus X , consists of a central nucleotide-binding domain (NB-ARC) flanked by a carboxyl-terminal leucine-rich repeat (LRR) domain and an amino-terminal coiled-coil (CC) domain. Rx1 activity is strictly regulated by interdomain interactions between the NB-ARC and LRR, but the contribution of the CC domain in regulating Rx1 activity or immune signaling is not fully understood. Therefore, we used a structure-informed approach to investigate the role of the CC domain in Rx1 functionality...
November 2018: Plant Physiology
https://www.readbyqxmd.com/read/30180203/the-health-impact-of-human-papillomavirus-vaccination-in-the-situation-of-primary-human-papillomavirus-screening-a-mathematical-modeling-study
#16
Suzette M Matthijsse, Steffie K Naber, Jan A C Hontelez, Roel Bakker, Marjolein van Ballegooijen, Iris Lansdorp-Vogelaar, Inge M C M de Kok, Harry J de Koning, Joost van Rosmalen, Sake J de Vlas
BACKGROUND: Human papillomavirus (HPV) vaccination and the implementation of primary HPV screening in the Netherlands will lead to a lower cervical disease burden. For evaluation and further improvement of prevention, it is important to estimate the magnitude and timing of health benefits of current and alternative vaccination strategies such as vaccination of boys or adults. METHODS AND FINDINGS: We evaluated the impact of the current girls-only vaccination program and alternative strategies on cervical disease burden among the first four vaccinated five-year birth cohorts, given the context of primary HPV screening...
2018: PloS One
https://www.readbyqxmd.com/read/30177338/the-effect-of-revascularization-of-a-chronic-total-coronary-occlusion-on-electrocardiographic-variables-a-sub-study-of-the-explore-trial
#17
Ivo M van Dongen, Maarten Z H Kolk, Joëlle Elias, Veronique M F Meijborg, Ruben Coronel, Jacques M T de Bakker, Bimmer E P M Claessen, Ronak Delewi, Dagmar M Ouweneel, Esther M Scheunhage, René J van der Schaaf, Maarten-Jan Suttorp, Matthijs Bax, Koen M Marques, Pieter G Postema, Arthur A M Wilde, José P S Henriques
INTRODUCTION: Chronic total coronary occlusions (CTOs) have been associated with a higher prevalence of ventricular arrhythmias compared to patients without a CTO. We evaluated the effect of CTO revascularization on electrocardiographic (ECG) variables. METHODS: We studied a selection of ST-elevation myocardial infarction patients with a concomitant CTO enrolled in the EXPLORE trial. ECG variables and cardiac function were analysed at baseline and at 4 months follow-up...
September 2018: Journal of Electrocardiology
https://www.readbyqxmd.com/read/30169657/a-comprehensive-evaluation-of-the-genetic-architecture-of-sudden-cardiac-arrest
#18
Foram N Ashar, Rebecca N Mitchell, Christine M Albert, Christopher Newton-Cheh, Jennifer A Brody, Martina Müller-Nurasyid, Anna Moes, Thomas Meitinger, Angel Mak, Heikki Huikuri, M Juhani Junttila, Philippe Goyette, Sara L Pulit, Raha Pazoki, Michael W Tanck, Marieke T Blom, XiaoQing Zhao, Aki S Havulinna, Reza Jabbari, Charlotte Glinge, Vinicius Tragante, Stefan A Escher, Aravinda Chakravarti, Georg Ehret, Josef Coresh, Man Li, Ronald J Prineas, Oscar H Franco, Pui-Yan Kwok, Thomas Lumley, Florence Dumas, Barbara McKnight, Jerome I Rotter, Rozenn N Lemaitre, Susan R Heckbert, Christopher J O'Donnell, Shih-Jen Hwang, Jean-Claude Tardif, Martin VanDenburgh, André G Uitterlinden, Albert Hofman, Bruno H C Stricker, Paul I W de Bakker, Paul W Franks, Jan-Hakan Jansson, Folkert W Asselbergs, Marc K Halushka, Joseph J Maleszewski, Jacob Tfelt-Hansen, Thomas Engstrøm, Veikko Salomaa, Renu Virmani, Frank Kolodgie, Arthur A M Wilde, Hanno L Tan, Connie R Bezzina, Mark Eijgelsheim, John D Rioux, Xavier Jouven, Stefan Kääb, Bruce M Psaty, David S Siscovick, Dan E Arking, Nona Sotoodehnia
Aims: Sudden cardiac arrest (SCA) accounts for 10% of adult mortality in Western populations. We aim to identify potential loci associated with SCA and to identify risk factors causally associated with SCA. Methods and results: We carried out a large genome-wide association study (GWAS) for SCA (n = 3939 cases, 25 989 non-cases) to examine common variation genome-wide and in candidate arrhythmia genes. We also exploited Mendelian randomization (MR) methods using cross-trait multi-variant genetic risk score associations (GRSA) to assess causal relationships of 18 risk factors with SCA...
November 21, 2018: European Heart Journal
https://www.readbyqxmd.com/read/30160799/total-and-high-affinity-corticosteroid-binding-globulin-depletion-in-septic-shock-is-associated-with-mortality
#19
Emily J Meyer, Marni A Nenke, Wayne Rankin, John G Lewis, Elisabeth Konings, Maarten Slager, Tim C Jansen, Jan Bakker, Johannes Hofland, Richard A Feelders, David J Torpy
CONTEXT: Corticosteroid-binding globulin (CBG) and albumin transport circulating cortisol. Cleavage of high-affinity CBG (haCBG) by neutrophil elastase at inflammatory sites causes cortisol release into tissues, facilitating immunomodulatory effects. OBJECTIVE: To determine whether depletion of haCBG is related to mortality in septic shock. DESIGN: A single-center prospective observational cohort study of patients recruited with critical illness or septic shock, using serum samples collected at 0, 8, 24, 48 and 72 hours...
August 30, 2018: Clinical Endocrinology
https://www.readbyqxmd.com/read/30136140/time-limited-trial-of-intensive-care-treatment-an-overview-of-current-literature
#20
REVIEW
Eva E Vink, Elie Azoulay, Arthur Caplan, Erwin J O Kompanje, Jan Bakker
In critically ill patients, it is frequently challenging to identify who will benefit from admission to the intensive care unit and life-sustaining interventions when the chances of a meaningful outcome are unclear. In addition, the acute illness not only affects the patients but also family members or surrogates who often are overwhelmed and unable to make thoughtful decisions. In these circumstances, a time-limited trial (TLT) of intensive care treatment can be helpful. A TLT is an agreement to initiate all necessary treatments or treatments with clearly delineated limitations for a certain period of time to gain a more realistic understanding of the patient's chances of a meaningful recovery or to ascertain the patient's wishes and values...
September 2018: Intensive Care Medicine
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