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JOURNAL ARTICLE
S Prasad, S Beg, D Badran, L Masciullo, C Huddy, A Khalil
OBJECTIVE: Twin pregnancies are associated with increased perinatal mortality and morbidity, but long-term neurodevelopmental outcomes remain under-investigated. The primary objective was to investigate the incidence of adverse neurodevelopment after one year of age in complicated monochorionic diamniotic (MCDA) twin pregnancies compared with uncomplicated twin pregnancies. METHODS: This was a prospective cohort study conducted at St George's University Hospital NHS Foundation Trust, London...
August 7, 2023: Ultrasound in Obstetrics & Gynecology
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JOURNAL ARTICLE
Y Kalchev, P Argirova, I Boev, A Yaneva, N Vatev, M Stoycheva, M Murdjeva
BACKGROUND: Bacterial meningitis is a life-threatening disease with high mortality and common long-term sequelae. The inflammatory response in the subarachnoid space, modulated by different cytokines, plays a major role in the pathogenesis of acute central nervous system infections. We aimed to examine correlations of interleukin (IL)-6, IL-8, IL-10, IL-12(p40), and tumor necrosis factor (TNF)-α levels with disease severity, complications, and outcome in patients with acute bacterial meningitis...
August 4, 2023: Cytokine
#23
JOURNAL ARTICLE
Ivan Lechner, Martin Reindl, Christina Tiller, Magdalena Holzknecht, Priscilla Fink, Felix Troger, Georg Angerer, Simon Angerer, Benjamin Henninger, Agnes Mayr, Gert Klug, Axel Bauer, Bernhard Metzler, Sebastian J Reinstadler
Background Severity of myocardial tissue injury is a main determinant of morbidity and death related to ST-segment-elevation myocardial infarction (STEMI). Temporal trends of infarct characteristics at the myocardial tissue level have not been described. This study sought to assess temporal trends in infarct characteristics through a comprehensive assessment by cardiac magnetic resonance imaging at a standardized time point early after STEMI. Methods and Results We analyzed patients with STEMI treated with percutaneous coronary intervention at the University Hospital of Innsbruck who underwent cardiac magnetic resonance imaging between 2005 and 2021...
August 2023: Journal of the American Heart Association
#24
JOURNAL ARTICLE
Atsuho Morita, Kazuma Yagi, Takanori Asakura, Ho Namkoong, Yasunori Sato, Takunori Ogawa, Tatsuya Kusumoto, Shoji Suzuki, Hiromu Tanaka, Ho Lee, Satoshi Okamori, Shuhei Azekawa, Kensuke Nakagawara, Masanori Kaji, Genta Nagao, Yohei Funatsu, Yoshifumi Kimizuka, Hirofumi Kamata, Tomoyasu Nishimura, Makoto Ishii, Koichi Fukunaga, Naoki Hasegawa
BACKGROUND: The long-term exercise tolerance changes in patients with nontuberculous mycobacterial pulmonary disease (NTM-PD) are of great interest because of its chronic course. This study aimed to characterize the associations between changes over time in six-minute walking test (6MWT) parameters and clinical parameters in patients with NTM-PD. METHODS: Overall, 188 patients with NTM-PD, visiting outpatient clinics at Keio University Hospital from April 2012 to March 2020 were included in the study...
July 6, 2023: BMC Pulmonary Medicine
#25
JOURNAL ARTICLE
E Kalafat, B Liu, I Barratt, R Bhate, A Papageorghiou, A Khalil
OBJECTIVE: The main aim of this study was to investigate the perinatal outcomes of dichorionic twin pregnancies complicated by selective fetal growth restriction (sFGR). DESIGN: Retrospective cohort study. SETTING: Tertiary reference centre. POPULATION: Dichorionic twin pregnancies complicated by sFGR between 2000 and 2019 in St George's University Hospital. METHODS: Regression analyses were performed using generalised linear models and mixed-effects generalised linear models where appropriate to account for pregnancy level dependency in variables...
June 12, 2023: BJOG: An International Journal of Obstetrics and Gynaecology
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REVIEW
Rochelle D Sylvester, Teck K Khong
Commentary on: Heerspink HJL, Stefánsson BV, Correa-Rotter R, et al Dapagliflozin in patients with chronic kidney disease. N Engl J Med 2020;383:1436-46. Series Editor: Dr Teck Khong, DTB Associate Editor, Clinical Pharmacology, St George's, University of London, UK.
August 2023: Drug and Therapeutics Bulletin
#27
JOURNAL ARTICLE
Koichiro Takahashi, Tomotaka Kawayama, Ayako Takamori, Hiroki Tashiro, Takashi Kinoshita, Koichi Takagi, Kei Yamasaki, Kentaro Machida, Atsushi Kawaguchi, Kazuhiro Yatera, Hiromasa Inoue
INTRODUCTION: Bronchodilators, including long-acting muscarinic antagonists (LAMA) and long-acting beta 2 agonists (LABA), are the main treatments for chronic obstructive pulmonary disease (COPD). The efficacy of triple therapy (inhaled corticosteroids/LAMA/LABA) has also been reported. However, the effect of triple therapy on patients with mild-to-moderate COPD has not yet been clarified. This study aims to investigate the safety and efficacy of triple therapy, compared with LAMA/LABA combination therapy, for lung function and health-related quality of life in patients with mild-to-moderate COPD and identify baseline characteristics and biomarkers to predict responders and non-responders to triple therapy...
May 2023: BMJ Open Respiratory Research
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JOURNAL ARTICLE
Stefan Malesevic, Noriane A Sievi, Patrick Baumgartner, Katharina Roser, Grit Sommer, Dörthe Schmidt, Florence Vallelian, Ilijas Jelcic, Christian F Clarenbach, Malcolm Kohler
A growing number of patients with SARS-CoV-2 infections experience long-lasting symptoms. Even patients who suffered from a mild acute infection show a variety of persisting and debilitating neurocognitive, respiratory, or cardiac symptoms (Long-Covid syndrome), consequently leading to limitations in everyday life. Because data on health-related quality of life (HRQoL) is scarce, we aimed to characterize the impact of Long-Covid symptoms after a mild or moderate acute infection on HRQoL. In this observational study, outpatients seeking counseling in the interdisciplinary Post-Covid consultation of the University Hospital Zurich with symptoms persisting for more than 4 weeks were included...
May 12, 2023: Scientific Reports
#29
JOURNAL ARTICLE
Betül Doğantekin, Başak Çakır Güney, Semiha Çelik Ekinci, Zeliha Serindağ, Nurgül Tükel, Sinem Akkaya Işık, Süleyman Kılıç, Mustafa Kaplan
BACKGROUND: Shortand long-term lung damage after coronavirus disease 2019 (COVID-19) has been emphasized in many studies, but pulmonary-specific health-related quality of life (HRQOL) has been examined only in a limited capacity. OBJECTIVES: In this study, we aimed to assess pulmonary-specific HRQOL and dyspnea among patients hospitalized for COVID-19 by applying the St George's Respiratory Questionnaire (SGRQ) to patient groups 1, 3 and 6 months following discharge (groups T1, T3 and T6)...
April 24, 2023: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
#30
JOURNAL ARTICLE
Zubair Ahmad Thoker, Karan Madan, Saurabh Mittal, Pawan Tiwari, Tajamul Hussain Shah, Anant Mohan, Vijay Hadda, Randeep Guleria
Background and objective There is a dearth of studies on the clinical presentation of patients with post-pulmonary tuberculosis (PTB) sequelae and its impact on their quality of life (QoL). In light of this, we conducted this study to analyze the clinical profile and QoL in patients with post-PTB sequelae. Methods Patients with a history of treated PTB and evidence of radiological damage were enrolled prospectively from November 2018 till June 2020 to study their clinical profile and QoL as per the eligibility criteria...
March 2023: Curēus
#31
JOURNAL ARTICLE
Brian Hitsman, George D Papandonatos, Jacqueline K Gollan, Mark D Huffman, Raymond Niaura, David C Mohr, Anna Veluz-Wilkins, Su Fen Lubitz, Anita Hole, Frank T Leone, Sadiya S Khan, Erica N Fox, Anna-Marika Bauer, E Paul Wileyto, Joseph Bastian, Robert A Schnoll
BACKGROUND AND AIMS: Treatment of depression-related psychological factors related to smoking behavior may improve rates of cessation among adults with major depressive disorder (MDD). This study measured the efficacy and safety of 12 weeks of behavioral activation for smoking cessation (BASC), varenicline, and their combination. DESIGN: Randomized, placebo-controlled, 2x2 factorial design comparing BASC vs. standard behavioral treatment (ST) and varenicline vs...
April 17, 2023: Addiction
#32
JOURNAL ARTICLE
Gabrielle Walcott-Bedeau, Ernesto Navarro Garcia, Hiba Al-Rubaye, Ariana Stergiou, Kesava Mandalaneni
Objective This article explores the value of hosting a grassroots neuroscience workshop that facilitates near-peer engagement between year-one medical students and local Brain Bee finalists (high school students). Near-peer mentoring is a formal relationship in which more academically advanced students guide immediate junior students. We hypothesized that similar activities have teaching, learning, and psychosocial benefits for all and can be easily replicated. Activity The Grenada National Brain Bee Challenge was launched in 2009 as a competition for high school students...
March 2023: Curēus
#33
MULTICENTER STUDY
Samantha Knights, Smriti Prasad, Erkan Kalafat, Anahita Dadali, Pam Sizer, Francoise Harlow, Asma Khalil
BACKGROUND: Accurate knowledge of fetal presentation at term is vital for optimal antenatal and intrapartum care. The primary objective was to compare the impact of routine third trimester ultrasound or point-of-care ultrasound (POCUS) with standard antenatal care, on the incidence of overall and proportion of all term breech presentations that were undiagnosed at term, and on the related adverse perinatal outcomes. METHODS AND FINDINGS: This was a retrospective multicentre cohort study where we included data from St...
April 2023: PLoS Medicine
#34
MULTICENTER STUDY
Miklos Rohla, Fabrice Temperli, George C M Siontis, Roland Klingenberg, Baris Gencer, Nicolas Rodondi, Sarah Bär, David Nanchen, Francois Mach, Jonas D Häner, Thomas Pilgrim, Olivier Muller, Christian M Matter, Thomas Lüscher, Marco Roffi, Dik Heg, Stephan Windecker, Lorenz Räber
AIMS: Routine revascularization in patients with ST-segment elevation myocardial infarction (STEMI) presenting >48 h after symptom onset is not recommended. METHODS AND RESULTS: We compared outcomes of STEMI patients undergoing percutaneous coronary intervention (PCI) according to total ischaemic time. Patients included in the Bern-PCI registry and the Multicenter Special Program University Medicine ACS (SPUM-ACS) between 2009 and 2019 were analysed. Based on symptom-to-balloon-time, patients were categorized as early (<12 h), late (12-48 h), or very late presenters (>48 h)...
June 2, 2023: European Heart Journal. Acute Cardiovascular Care
#35
JOURNAL ARTICLE
Nikita S D Sahadeo, Soren Nicholls, Filipe R R Moreira, Áine O'Toole, Vernie Ramkissoon, Charles Whittaker, Verity Hill, John T McCrone, Nicholas Mohammed, Anushka Ramjag, Arianne Brown Jordan, Sarah C Hill, Risha Singh, Sue-Min Nathaniel-Girdharrie, Avery Hinds, Nuala Ramkissoon, Kris V Parag, Naresh Nandram, Roshan Parasram, Zobida Khan-Mohammed, Lisa Edghill, Lisa Indar, Aisha Andrewin, Rhonda Sealey-Thomas, Pearl McMillan, Ayoola Oyinloye, Kenneth George, Irad Potter, John Lee, David Johnson, Shawn Charles, Narine Singh, Jacquiline Bisesor-McKenzie, Hazel Laws, Sharon Belmar-George, Simone Keizer-Beache, Sharra Greenaway-Duberry, Nadia Ashwood, Jerome E Foster, Karla Georges, Rahul Naidu, Marsha Ivey, Stanley Giddings, Rajini Haraksingh, Adesh Ramsubhag, Jayaraj Jayaraman, Chinnaraja Chinnadurai, Christopher Oura, Oliver G Pybus, Joy St John, Gabriel Gonzalez-Escobar, Nuno R Faria, Christine V F Carrington
The COVID-19 pandemic highlighted the importance of global genomic surveillance to monitor the emergence and spread of SARS-CoV-2 variants and inform public health decision-making. Until December 2020 there was minimal capacity for viral genomic surveillance in most Caribbean countries. To overcome this constraint, the COVID-19: Infectious disease Molecular epidemiology for PAthogen Control & Tracking (COVID-19 IMPACT) project was implemented to establish rapid SARS-CoV-2 whole genome nanopore sequencing at The University of the West Indies (UWI) in Trinidad and Tobago (T&T) and provide needed SARS-CoV-2 sequencing services for T&T and other Caribbean Public Health Agency Member States (CMS)...
2023: PLOS Glob Public Health
#36
JOURNAL ARTICLE
Devra Davis, Dugald Seely, Christopher Morash, Jennifer Armstrong, Maxwell Meng, Phillip Lowe, Mikhail Kogan
CONTEXT: Bladder cancer is the fourth-most-common cancer in males in the U.S., who develop about 90% of the high-grade, carcinoma in situ (CIS) of non-muscle involved disease (NMIBC). Smoking and occupational carcinogens are well-known causes. For females without known risk factors, bladder cancer can be regarded as a sentinel environmental cancer. It's also one of the costliest to treat due to its high rate of recurrence. No treatment innovations have occurred in nearly two decades; intravesical instillation of Bacillus Calmette-Guerin (BCG), an agent in short supply globally, or Mitomycin-C (MIT-C) is effective in about 60% of cases...
March 20, 2023: Alternative Therapies in Health and Medicine
#37
JOURNAL ARTICLE
Michal Rychlik, Georg Wendland, Michal Jackowski, Roland Rennert, Klaus-Dieter Schaser, Joerg Nowotny
PURPOSE: Among various test methods for different human joints, the use of robot systems has attracted major interest and inherits the potential to become a gold standard in biomechanical testing in the future. A key issue associated with those robot-based platforms is the accurate definition of parameters, e.g., tool center point (TCP), length of tool or anatomical trajectories of movements. These must be precisely correlated to the physiological parameters of the examined joint and its corresponding bones...
March 3, 2023: Journal of Orthopaedic Surgery and Research
#38
JOURNAL ARTICLE
Mohammed K Rashid, George Wells, Derek Y So, Aun-Yeong Chong, Alexander Dick, Michael Froeschl, Christopher Glover, Benjamin Hibbert, Marino Labinaz, Juan Russo, Jordan Bernick, Michel Le May
OBJECTIVES: Presentation with ST-segment-elevation myocardial infarction (STEMI) during off-hours may impact timely reperfusion and clinical outcomes. We investigated the association between off-hours presentation, door-to-balloon time, and in-hospital mortality in patients with STEMI referred for primary percutaneous coronary intervention (PCI). METHODS: We included consecutive patients referred for primary PCI at the University of Ottawa Heart Institute between July 2004 and December 2017...
February 24, 2023: Journal of Invasive Cardiology
#39
JOURNAL ARTICLE
Roya Anahita Mousavi, Dominik Roth, Christian Wallmüller, Gernot Pichler, Peter Stratil, Wolfgang Schreiber, Georg Delle-Karth, Andreas Schober
OBJECTIVES: The aim of this study was to find out if the decrease in acute myocardial infarction (AMI) admissions during the first COVID-19 lockdowns (LD), which was described by previous studies, occurred equally in all LD periods (LD1, LD2, LD2021), which had identical restrictions. Further, we wanted to analyse if the decrease of AMI admission had any association with the 1-year mortality rate. DESIGN AND SETTING: This study is a prospective observational study of two centres that are participating in the Vienna ST-elevation myocardial infarction network...
February 8, 2023: BMJ Open
#40
JOURNAL ARTICLE
Nathan J Cheetham, Milla Kibble, Andrew Wong, Richard J Silverwood, Anika Knuppel, Dylan M Williams, Olivia K L Hamilton, Paul H Lee, Charis Bridger Staatz, Giorgio Di Gessa, Jingmin Zhu, Srinivasa Vittal Katikireddi, George B Ploubidis, Ellen J Thompson, Ruth C E Bowyer, Xinyuan Zhang, Golboo Abbasian, Maria Paz Garcia, Deborah Hart, Jeffrey Seow, Carl Graham, Neophytos Kouphou, Sam Acors, Michael H Malim, Ruth E Mitchell, Kate Northstone, Daniel Major-Smith, Sarah Matthews, Thomas Breeze, Michael Crawford, Lynn Molloy, Alex S F Kwong, Katie Doores, Nishi Chaturvedi, Emma L Duncan, Nicholas J Timpson, Claire J Steves
Background: SARS-CoV-2 antibody levels can be used to assess humoral immune responses following SARS-CoV-2 infection or vaccination, and may predict risk of future infection. Higher levels of SARS-CoV-2 anti-Spike antibodies are known to be associated with increased protection against future SARS-CoV-2 infection. However, variation in antibody levels and risk factors for lower antibody levels following each round of SARS-CoV-2 vaccination have not been explored across a wide range of socio-demographic, SARS-CoV-2 infection and vaccination, and health factors within population-based cohorts...
January 24, 2023: ELife
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