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https://www.readbyqxmd.com/read/29894263/sharing-expertise-when-immunology-meets-psychiatry-and-neuroscience
#1
Leo Honey
A radio programme investigating how a 'rogue' immune system could affect mental health led second-year nursing student at Kingston and St George's University Leo Honey to research the subject further, leohoney3@gmail.com.
June 14, 2018: British Journal of Nursing: BJN
https://www.readbyqxmd.com/read/29862956/health-related-qol-of-elderly-patients-with-pulmonary-m-avium-complex-disease-in-a-university-hospital
#2
T Asakura, M Ishii, K Ishii, S Suzuki, H Namkoong, S Okamori, H Kamata, K Yagi, Y Funatsu, T Betsuyaku, N Hasegawa
BACKGROUND: Little is known about the clinical characteristics and health-related quality of life (HQOL) of elderly patients with pulmonary Mycobacterium avium complex (pMAC) disease. OBJECTIVES: To evaluate HQOL using the 36-Item Short-Form Health Survey and St George's Respiratory Questionnaire (SGRQ) and to investigate the predictors of HQOL changes among elderly patients with pMAC disease. METHODS: This prospective cohort registry was conducted at Keio University Hospital, Tokyo, Japan, between May 2012 and July 2015 and included 84 patients with pMAC disease aged 75 years who had completed the HQOL questionnaire and 48 patients with pMAC disease who had been followed up and completed the HQOL questionnaire in cross-sectional and longitudinal analyses, respectively...
June 1, 2018: International Journal of Tuberculosis and Lung Disease
https://www.readbyqxmd.com/read/29862029/psychometric-properties-of-the-st-george-s-respiratory-questionnaire-in-patients-with-idiopathic-pulmonary-fibrosis-insights-from-the-inpulsis-trials
#3
Jeffrey J Swigris, Hilary Wilson, Dirk Esser, Craig S Conoscenti, Wibke Stansen, Nancy Kline Leidy, Kevin K Brown
Introduction: We evaluated the psychometric properties of the St George's Respiratory Questionnaire (SGRQ) in patients with idiopathic pulmonary fibrosis (IPF) using data from the two INPULSIS trials. Methods: Data from 1061 patients treated with nintedanib or placebo were pooled. Internal consistency, test-retest reliability, construct validity, known-groups validity, responsiveness and responder thresholds were examined. Results: Cronbach's α was 0...
2018: BMJ Open Respiratory Research
https://www.readbyqxmd.com/read/29786155/is-home-blood-pressure-monitoring-in-hypertensive-disorders-of-pregnancy-consistent-with-clinic-recordings
#4
Erkan Kalafat, Iffat Mir, Helen Perry, Basky Thilaganathan, Asma Khalil
OBJECTIVES: To assess the agreement of home blood-pressure monitoring (HBPM) and office blood pressure measurements in a cohort of pregnant women with Hypertensive Disorders of Pregnancy (HDP). METHODS: This was a cohort study at St George's Hospital, University of London conducted between years 2016 and 2017. The inclusion criteria were chronic hypertension, gestational hypertension or high risk of developing preeclampsia, no significant proteinuria and no hematological or biochemical abnormalities...
May 22, 2018: Ultrasound in Obstetrics & Gynecology
https://www.readbyqxmd.com/read/29701066/11th-gcc-closed-forum-cumulative-stability-matrix-stability-immunogenicity-assays-laboratory-manuals-biosimilars-chiral-methods-hybrid-lba-lcms-assays-fit-for-purpose-validation-china-food-and-drug-administration-bioanalytical-method-validation
#5
Rafiq Islam, Chad Briscoe, Joseph Bower, Stephanie Cape, Mark Arnold, Roger Hayes, Mark Warren, Shane Karnik, Bruce Stouffer, Yi Qun Xiao, Barry van der Strate, Daniel Sikkema, Xinping Fang, Ariana Tudoroniu, Rabab Tayyem, Ashley Brant, Franklin Spriggs, Colin Barry, Masood Khan, Anahita Keyhani, Jennifer Zimmer, Maria Cruz Caturla, Philippe Couerbe, Ardeshir Khadang, James Bourdage, Jim Datin, Jennifer Zemo, Nicola Hughes, Saadya Fatmi, Curtis Sheldon, Scott Fountain, Christina Satterwhite, Kelly Colletti, Jenifer Vija, Mathilde Yu, John Stamatopoulos, Jenny Lin, Jim Wilfahrt, Andrew Dinan, Susan Ohorodnik, James Hulse, Vimal Patel, Wei Garofolo, Natasha Savoie, Michael Brown, Damon Papac, Mike Buonarati, George Hristopoulos, Chris Beaver, Nadine Boudreau, Clark Williard, Yansheng Liu, Gene Ray, Dominic Warrino, Allan Xu, Rachel Green, Joanne Hayward-Sewell, John Marcelletti, Christina Sanchez, Michael Kennedy, Jessica St Charles, Mohammed Bouhajib, Corey Nehls, Edward Tabler, Jing Tu, Philip Joyce, Adriana Iordachescu, Ira DuBey, John Lindsay, Jim Yamashita, Edward Wells
The 11th Global CRO Council Closed Forum was held in Universal City, CA, USA on 3 April 2017. Representatives from international CRO members offering bioanalytical services were in attendance in order to discuss scientific and regulatory issues specific to bioanalysis. The second CRO-Pharma Scientific Interchange Meeting was held on 7 April 2017, which included Pharma representatives' sharing perspectives on the topics discussed earlier in the week with the CRO members. The issues discussed at the meetings included cumulative stability evaluations, matrix stability evaluations, the 2016 US FDA Immunogenicity Guidance and recent and unexpected FDA Form 483s on immunogenicity assays, the bioanalytical laboratory's role in writing PK sample collection instructions, biosimilars, CRO perspectives on the use of chiral versus achiral methods, hybrid LBA/LCMS assays, applications of fit-for-purpose validation and, at the Global CRO Council Closed Forum only, the status and trend of current regulated bioanalytical practice in China under CFDA's new BMV policy...
April 1, 2018: Bioanalysis
https://www.readbyqxmd.com/read/29668454/identification-of-the-external-branch-of-the-superior-laryngeal-nerve-during-thyroid-surgery
#6
Lyubka Aleksova, Metin M Ali, Djevdet I Chakarov, Zeynep M Yozgyur
AIM: To compare the level of intra-operative identification of external branch of the superior laryngeal nerve (EBSLN) through classical conventional clinical methods of prevention against those applying intraoperative neuromonitoring (IONM). MATERIALS AND METHODS: The study included 102 patients with interventions on the thyroid gland performed in the surgical clinics of St George University Hospital and the Department of Special Surgery of Plovdiv Medical University...
March 1, 2018: Folia Medica
https://www.readbyqxmd.com/read/29660172/predictive-accuracy-of-the-southwest-thames-obstetric-research-collaborative-stork-chorionicity-specific-twin-growth-charts-for-stillbirth-a-validation-study
#7
Erkan Kalafat, Mercedes Sebghati, Basky Thilaganathan, Asma Khalil
OBJECTIVE: Twin pregnancy is associated with 2-3 fold increased risk of stillbirth compared to singletons. Despite the fact that the growth pattern has been shown to differ in twins compared to singletons, it is controversial whether twin-specific growth charts should be routinely used. A major goal of prenatal ultrasound is to identify fetuses suffering from growth restriction at risk of stillbirth. The main aim of this study was to compare the performance of chorionicity-specific twin charts with singleton charts, both customized and non-customized, in the antenatal prediction of small-for-gestational age (SGA) stillborn and liveborn fetuses...
April 16, 2018: Ultrasound in Obstetrics & Gynecology
https://www.readbyqxmd.com/read/29581221/impact-of-type-2-myocardial-infarction-mi-on-hospital-level-mi-outcomes-implications-for-quality-and-public-reporting
#8
Sameer Arora, Paula D Strassle, Arman Qamar, Evan N Wheeler, Alexandra L Levine, Jacob A Misenheimer, Matthew A Cavender, George A Stouffer, Prashant Kaul
BACKGROUND: The International Classification of Diseases (ICD) coding system does not recognize type 2 myocardial infarction (MI) as a separate entity; therefore, patients with type 2 MI continue to be categorized under the general umbrella of non-ST-segment-elevation myocardial infarction (NSTEMI). We aim to evaluate the impact of type 2 MI on hospital-level NSTEMI metrics and discuss the implications for quality and public reporting. METHODS AND RESULTS: We conducted a single-center retrospective analysis of 1318 patients discharged with a diagnosis of NSTEMI between July 2013 and October 2014...
March 26, 2018: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29468771/home-blood-pressure-monitoring-in-a-hypertensive-pregnant-population
#9
H Perry, E Sheehan, B Thilaganathan, A Khalil
OBJECTIVE: The majority of patients with chronic or gestational hypertension do not develop pre-eclampsia. Home blood-pressure monitoring (HBPM) has the potential to offer a more accurate and acceptable means of monitoring hypertensive patients during pregnancy compared with traditional pathways of frequent outpatient monitoring. The aim of this study was to determine whether HBPM reduces visits to antenatal services and is safe in pregnancy. METHODS: This was a case-control study of 166 hypertensive pregnant women, which took place at St George's Hospital, University of London...
April 2018: Ultrasound in Obstetrics & Gynecology
https://www.readbyqxmd.com/read/29413500/evaluation-of-a-respiratory-symptom-diary-for-clinical-studies-of-idiopathic-pulmonary-fibrosis
#10
Elizabeth Dansie Bacci, Sean O'Quinn, Nancy Kline Leidy, Lindsey Murray, Margaret Vernon
BACKGROUND: There are no validated patient diaries for evaluating respiratory symptoms in idiopathic pulmonary fibrosis (IPF). PURPOSE: To evaluate the performance properties of the chronic obstructive pulmonary disease (COPD) Evaluating Respiratory Symptoms™ (E-RS™: COPD) measure in patients with IPF. METHODS: Concept elicitation and cognitive interviews were conducted with IPF patients to evaluate content validity, including comprehensiveness, relevance, and interpretability of E-RS™ items in this patient population...
January 2018: Respiratory Medicine
https://www.readbyqxmd.com/read/29396192/management-of-nursing-home-residents-following-acute-hospitalization-efficacy-of-the-regular-early-assessment-post-discharge-reap-intervention
#11
Nicholas J Cordato, Mary Kearns, Peter Smerdely, Katrin M Seeher, Matthew D Gardiner, Henry Brodaty
OBJECTIVES: Rehospitalization of nursing home (NH) residents is frequent, costly, potentially avoidable and associated with diminished quality of life and poor survival. This study aims to evaluate the impact and cost-effectiveness of the Regular Early Assessment Post-Discharge (REAP) protocol of coordinated specialist geriatrician and nurse practitioner visits on rates of rehospitalization, hospital length of stay, and emergency department presentations for NH residents recently discharged from hospital...
March 2018: Journal of the American Medical Directors Association
https://www.readbyqxmd.com/read/29341954/carbapenemase-production-of-clinical-isolates-acinetobacter-baumannii-and-pseudomonas-aeruginosa-from-a-bulgarian-university-hospital
#12
Atanaska P Petrova, Irina D Stanimirova, Ivan N Ivanov, Michael M Petrov, Tsonka M Miteva-Katrandzhieva, Vasil I Grivnev, Velichka S Kardjeva, Todor V Kantardzhiev, Mariana A Murdjeva
BACKGROUND: Production of Bla OXA-23, OXA-24, OXA-58 and hyperexpression of OXA-51 due to ISAba1 insertion sequence are the leading causes of carbapenem resistance in Acinetobacter baumannii. The loss of OprD transmembrane protein and the overexpression of some effl ux pumps are considered to be the main factors for carbapenem resistance in Pseudomonas aeruginosa whereas metallo-enzymes' production has a secondary role. AIM: Тo examine the carbapenem resistance due to carbapenemase production among clinically signifi cant Gram-negative non-fermenters from St George University hospital, Plovdiv: A...
December 20, 2017: Folia Medica
https://www.readbyqxmd.com/read/29341953/lethality-among-patients-with-hiv-aids-monitored-in-the-clinic-of-infectious-diseases-in-st-george-university-hospital-plovdiv-2010-2014
#13
Mariyana V Stoycheva, Nikolay T Vatev, Vania B Georgieva, Antonina P Dineva, Maria V Atanasova, Tatiana A Popova
BACKGROUND: The introduction of complex antiretroviral therapy has resulted in signifi cant decrease in the mortality rate of HIV positive patients, but it still remains unacceptably high, especially in some groups of patients. AIM: To investigate the death rate in patients with HIV/AIDS, lethality and mortality in co-infection, and the most common causes and predictors of fatal outcome, focused on early diagnosis and appropriate therapy. MATERIALS AND METHODS: The study included 53 deceased patients with HIV/AIDS, monitored at the Clinic of Infectious Diseases in St George University Hospital, Plovdiv between 01...
December 20, 2017: Folia Medica
https://www.readbyqxmd.com/read/29249628/an-analysis-of-blood-donation-barriers-experienced-by-north-american-and-caribbean-university-students-in-grenada-west-indies
#14
Benjamin W Dean, Sarah N Hewitt, Morgan C Begos, Angela Gomez, Locksley L McV Messam
OBJECTIVES: To estimate the associations of nationality, university program, donation history and gender, with blood donation barriers experienced by non-donating students on the day of a campus blood drive. This project focused particularly on nationality and the effect of the different blood donation cultures in the students' countries of origin. METHODS: A retrospective cohort study of 398 North American and Caribbean university students was conducted at St. George's University, Grenada, in 2010...
February 2018: Transfusion and Apheresis Science
https://www.readbyqxmd.com/read/29034705/considering-the-future-direction-of-children-s-and-young-people-s-nursing
#15
Sonya Clark, Alan Glasper, Jim Richardson
Sonya Clark, Senior Lecturer in Children's Nursing at Queen's University Belfast, Emeritus Professor Alan Glasper, from the University of Southampton and Jim Richardson, Senior Lecturer in Children's Nursing at Kingston University and St George's, University of London, discuss the concerns of the academic community.
October 12, 2017: British Journal of Nursing: BJN
https://www.readbyqxmd.com/read/28976902/clinical-laboratory-tests-in-some-acute-exogenous-poisonings
#16
Stoilka G Tufkova, Ivan V Yankov, Diana A Paskaleva
BACKGROUND: There is no specific toxicological screening of clinical laboratory parameters in clinical toxicology when it comes to acute exogenous poisoning. AIM: To determine routine clinical laboratory parameters and indicators for assessment of vital functions in patients with acute intoxications. MATERIALS AND METHODS: One hundred and fifty-three patients were included in the present study. They were hospitalized in the Department of Clinical Toxicology at St...
September 1, 2017: Folia Medica
https://www.readbyqxmd.com/read/28947014/characteristics-of-patients-with-increasing-copd-assessment-test-scores-within-3-years
#17
Hidehiro Irie, Shotaro Chubachi, Minako Sato, Akihiro Tsutsumi, Ichiro Nakachi, Naoki Miyao, Kazumi Nishio, Hidetoshi Nakamura, Koichiro Asano, Tomoko Betsuyaku
BACKGROUND: The chronic obstructive pulmonary disease (COPD) Assessment Test (CAT) is a subjective measure of quality of life. The aim of this study was to examine the characteristics of COPD patients with increasing CAT scores within 3 years. METHODS: Keio University and its affiliate hospitals conducted an observational COPD cohort study over 3 years. St. George's Respiratory Questionnaire (SGRQ) and CAT were completed at baseline and annually thereafter. Patients who had at least 3 CAT scores were included (n = 315)...
October 2017: Respiratory Medicine
https://www.readbyqxmd.com/read/28933002/mepolizumab-for-treating-severe-eosinophilic-asthma-an-evidence-review-group-perspective-of-a-nice-single-technology-appraisal
#18
REVIEW
Iñigo Bermejo, Matt Stevenson, Katy Cooper, Sue Harnan, Jean Hamilton, Mark Clowes, Christopher Carroll, Tim Harrison, Shironjit Saha
As part of its single technology appraisal (STA) process, the National Institute for Health and Care Excellence (NICE) invited the company (GlaxoSmithKline) that manufactures mepolizumab (Nucala® ) to submit evidence on the clinical and cost effectiveness of mepolizumab for the treatment of severe eosinophilic asthma. The School of Health and Related Research Technology Appraisal Group (ScHARR-TAG) at the University of Sheffield was commissioned to act as the independent evidence review group (ERG). The ERG produced a review of the evidence for the clinical and cost effectiveness of mepolizumab as add-on to standard of care (SoC) compared with SoC and omalizumab, based upon the company's submission to NICE...
February 2018: PharmacoEconomics
https://www.readbyqxmd.com/read/28928190/interdisciplinary-model-of-care-radicals-for-early-detection-and-management-of-chronic-obstructive-pulmonary-disease-copd-in-australian-primary-care-study-protocol-for-a-cluster-randomised-controlled-trial
#19
RANDOMIZED CONTROLLED TRIAL
Jenifer Liang, Michael J Abramson, Nicholas Zwar, Grant Russell, Anne E Holland, Billie Bonevski, Ajay Mahal, Benjamin van Hecke, Kirsten Phillips, Paula Eustace, Eldho Paul, Kate Petrie, Sally Wilson, Johnson George
INTRODUCTION: Up to half of all smokers develop clinically significant chronic obstructive pulmonary disease (COPD). Gaps exist in the implementation and uptake of evidence-based guidelines for managing COPD in primary care. We describe the methodology of a cluster randomised controlled trial (cRCT) evaluating the efficacy and cost-effectiveness of an interdisciplinary model of care aimed at reducing the burden of smoking and COPD in Australian primary care settings. METHODS AND ANALYSIS: A cRCT is being undertaken to evaluate an interdisciplinary model of care (RADICALS - Review of Airway Dysfunction and Interdisciplinary Community-based care of Adult Long-term Smokers)...
September 18, 2017: BMJ Open
https://www.readbyqxmd.com/read/28910351/lab-meets-real-life-a-laboratory-assessment-of-spontaneous-thought-and-its-ecological-validity
#20
Christine Kuehner, Annett Welz, Iris Reinhard, Georg W Alpers
People's minds frequently wander towards self-generated thoughts, which are unrelated to external stimuli or demands. These phenomena, referred to as "spontaneous thought" (ST) and "mind wandering" (MW), have previously been linked with both costs and benefits. Current assessments of ST and MW have predominantly been conducted in the laboratory, whereas studies on the ecological validity of such lab-related constructs and their interrelations are rare. The current study examined the stability of ST dimensions assessed in the lab and their predictive value with respect to MW, repetitive negative thought (uncontrollable rumination, RUM), and affect in daily life...
2017: PloS One
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