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Systolic dysfunction

Richard M Cubbon, Judith E Lowry, Michael Drozd, Marlous Hall, John Gierula, Maria F Paton, Rowena Byrom, Lorraine C Kearney, Julian H Barth, Mark T Kearney, Klaus K Witte
PURPOSE: Low 25-hydroxyvitamin D (25[OH]D) concentrations have been associated with adverse outcomes in selected populations with established chronic heart failure (CHF). However, it remains unclear whether 25[OH]D deficiency is associated with mortality and hospitalisation in unselected patients receiving contemporary medical and device therapy for CHF. METHODS: We prospectively examined the prevalence and correlates of 25[OH]D deficiency in 1802 ambulatory patients with CHF due to left ventricular systolic dysfunction (left ventricular ejection fraction ≤ 45%) attending heart failure clinics in the north of England...
August 18, 2018: European Journal of Nutrition
Shirley Sze, Pierpaolo Pellicori, Jufen Zhang, Andrew L Clark
BACKGROUND: In patients with chronic heart failure (CHF), malnutrition might be related to right heart dysfunction and venous congestion, which predispose to bowel oedema and malabsorption, thereby leading to malnutrition. We explored the relation between congestion, malnutrition and mortality in a large cohort of ambulatory patients with CHF. METHODS: We assessed malnutrition using the Geriatric Nutritional Risk Index (GNRI). Congestion was defined by echocardiography (raised right atrial pressure (RAP)=dilated inferior vena cava≥21 mm/raised pulmonary artery systolic pressure (PAsP)=transtricuspid gradient of ≥36 mm Hg/right ventricular systolic dysfunction (RVSD)=tricuspid annular plane systolic excursion <17 mm)...
August 18, 2018: Heart: Official Journal of the British Cardiac Society
Elisa Zaragoza-Macias, Ali N Zaidi, Nandini Dendukuri, Ariane Marelli
Patients with systemic morphological right ventricles (RVs), including congenitally corrected transposition of the great arteries and dextro-transposition of the great arteries with a Mustard or Senning atrial baffle repair, have a high likelihood of developing systemic ventricular dysfunction. Unfortunately, there are a limited number of clinical studies on the efficacy of medical therapy for systemic RV dysfunction. We performed a systematic review and meta-analysis to assess the effect of angiotensin-converting enzyme (ACE) inhibitors, angiotensin-receptor blockers (ARBs), beta blockers, and aldosterone antagonists in adults with systemic RVs...
August 9, 2018: Journal of the American College of Cardiology
Roberto V P Ribeiro, Mitesh V Badiwala, Danny Ramzy, Laura C Tumiati, Vivek Rao
OBJECTIVE: Hypertonic saline (HTS) has potent immune and vascular effects. We assessed recipient pretreatment with HTS on allograft function in a porcine model of heart transplantation and hypothesized that HTS infusion would limit endothelial and left ventricular (LV) dysfunction following transplantation. METHODS: Heart transplants were performed after 6 hours of cold ischemic storage. Recipient pigs were randomized to treatment with or without HTS (7.5% NaCl) before cardiopulmonary bypass (CPB)...
July 21, 2018: Journal of Thoracic and Cardiovascular Surgery
Ercan Yuvanc, Mehmet Tolga Dogru, Vedat Simsek, Hüseyin Kandemir, Devrim Tuglu
PURPOSE: Hypertension (HT) is known to be of the main risk factors for erectile dysfunction (ED). But non-dipping (<%10 drop in the night) of HT is not investigated truly. The aim of this study was to test the hypothesis that the non-dipper hypertensive patients are more prone to develop erectile dysfunction. MATERIALS AND METHODS: This was a cross-sectional clinical study. 70 HT patients diagnosed by Ambulatory blood pressure monitoring (ABPM) were classified into 3 groups (No ED, mild to moderate and severe) according to their International Index of Erectile Function (IIEF) scores...
August 18, 2018: Urology Journal
Sébastien Foulquier, Pawel Namsolleck, Britt T Van Hagen, Irina Milanova, Mark J Post, W Matthijs Blankesteijn, Bart P Rutten, Jos Prickaerts, Robert J Van Oostenbrugge, Thomas Unger
The causal relation between hypertension and cerebral small vessel disease (cSVD) remains elusive, and appropriate animal models are scarce. We aimed to assess the relevance of prolonged angiotensin II-induced hypertension in mice for the study of cSVD.Adult male C57BL/6 mice were continuously infused for 3 months with Angiotensin II (Ang II; 2 µg/kg/min, sc) or saline (control) via osmotic minipumps. Blood pressure, neurological function, locomotor activity, and working memory (Y-maze alternation task) were assessed throughout the study...
August 17, 2018: Hypertension Research: Official Journal of the Japanese Society of Hypertension
Natali Froese, Honghui Wang, Carolin Zwadlo, Yong Wang, Andrea Grund, Anna Gigina, Melanie Hofmann, Katja Kilian, Gesine Scharf, Mortimer Korf-Klingebiel, Anna Melchert, Maria Elena Ricci Signorini, Caroline Halloin, Robert Zweigerdt, Ulrich Martin, Ina Gruh, Kai C Wollert, Robert Geffers, Johann Bauersachs, Joerg Heineke
Maladaptive cardiac remodeling after myocardial infarction (MI) is increasingly contributing to the prevalence of chronic heart failure. Women show less severe remodeling, a reduced mortality and a better systolic function after MI compared to men. Although sex hormones are being made responsible for these differences, it remains currently unknown how this could be translated into therapeutic strategies. Because we had recently demonstrated that inhibition of the conversion of testosterone to its highly active metabolite dihydrotestosterone (DHT) by finasteride effectively reduces cardiac hypertrophy and improves heart function during pressure overload, we asked here whether this strategy could be applied to post-MI remodeling...
August 14, 2018: Journal of Molecular and Cellular Cardiology
Sunit Tolia, Zubair Khan, Gunjan Gholkar, Marcel Zughaib
Background: Routine ambulatory echocardiographic estimates of left ventricular (LV) filling pressures are not cost-effective and are occasionally fraught with anatomic, physiologic as well as logistical limitations. The use of implantable hemodynamic devices such as CardioMEMS Heart Failure (HF) System has been shown to reduce HF-related readmission rates by remote monitoring of LV filling pressures. Little is known about the correlation between CardioMEMS and echocardiography-derived estimates of central hemodynamics...
2018: Cardiology Research and Practice
Hassan Tahir, Sarina Sachdev, Landai Nguyen, Nikky Bardia, Bassam Omar, Michael V Cohen
Despite the development of ventricular assist devices, cardiac transplantation remains an important procedure for patients with advanced heart failure. The number of transplants done annually has remained stable because of lack of of donors. Left ventricular systolic dysfunction remains one of the most important reasons for seeking a donor heart. Myocardial stunning is an important cause of reversible systolic dysfunction. Electrical injury is a recognized cause of myocardial stunning with variable duration ranging from days to weeks...
August 2018: Cardiology Research
Yi-Hsiu Chung, Kuan-Ying Lu, Shao-Chieh Chiu, Chi-Jen Lo, Li-Man Hung, Jiung-Pang Huang, Mei-Ling Cheng, Chao-Hung Wang, Cheng-Kun Tsai, Yu-Chun Lin, Shang-Hung Chang, Gigin Lin
Background: High-fat diet (HFD) induces systemic insulin resistance leading to myocardial dysfunction. We aim to characterize the early adaptations of myocardial glucose utility to HFD-induced insulin resistance. Methods: Male Sprague-Dawley rats were assigned into two groups, fed a regular chow diet or HFD ad libitum for 10 weeks. We used in vivo imaging of cardiac magnetic resonance (CMR), 18 F-FDG PET, and ex vivo nuclear magnetic resonance (NMR) metabolomic analysis for the carbon-13-labeled glucose ([U-13 C]Glc) perfused myocardium...
2018: Contrast Media & Molecular Imaging
Lee S Nguyen, Pierre Squara, Julien Amour, Daniel Carbognani, Kamel Bouabdallah, Stéphane Thierry, Caroline Apert-Verneuil, Aurélie Moyne, Bernard Cholley
BACKGROUND: Low cardiac output syndrome (LCOS) is a severe condition which can occur after cardiac surgery, especially among patients with pre-existing left ventricular dysfunction. Dobutamine, its first-line treatment, is associated with sinus tachycardia. This study aims to assess the ability of intravenous ivabradine to decrease sinus tachycardia associated with dobutamine infused for LCOS after coronary artery bypass graft (CABG) surgery. METHODS: In a phase 2, multi-center, single-blind, randomized controlled trial, patients with left ventricular ejection fraction below 40% presenting sinus tachycardia of at least 100 beats per minute (bpm) following dobutamine infusion for LCOS after CABG surgery received either intravenous ivabradine or placebo (three ivabradine for one placebo)...
August 17, 2018: Critical Care: the Official Journal of the Critical Care Forum
Bert Andersson, Lilin She, Ru-San Tan, Panniyammakal Jeemon, Krzysztof Mokrzycki, Matthias Siepe, Alexander Romanov, Liliana E Favaloro, Ljubomir T Djokovic, P Krishnam Raju, Piotr Betlejewski, Normand Racine, Adam Ostrzycki, Weerachai Nawarawong, Siuli Das, Jean L Rouleau, George Sopko, Kerry L Lee, Eric J Velazquez, Julio A Panza
Aims: Hypertension (HTN) is a well-known contributor to cardiovascular disease, including heart failure (HF) and coronary artery disease, and is the leading risk factor for premature death world-wide. A J- or U-shaped relationship has been suggested between blood pressure (BP) and clinical outcomes in different studies. However, there is little information about the significance of BP on the outcomes of patients with coronary artery disease and left ventricular dysfunction. This study aimed to determine the relationship between BP and mortality outcomes in patients with ischaemic cardiomyopathy...
August 2, 2018: European Heart Journal
Jill M Wecht, Joseph P Weir, Caitlyn G Katzelnick, Glenn Wylie, Mastanna Eraifej, Nhuguynh Nguyen, Trevor Dyson-Hudson, William A Bauman, Nancy Chiaravalotti
Cognitive deficits are prevalent in the spinal cord injury (SCI) population, and consensus suggests that concomitant traumatic brain injury or co-morbid conditions are primarily responsible for these deficits. However, mounting evidence supports the possibility that systemic and cerebral hemodynamic dysfunction may contribute to the cognitive deficits reported in persons with SCI. We sought to determine the contribution of changes in blood pressure (BP) and changes in cerebral blood flow velocity (CBFv) to test performance on the Symbol Digit Modalities Test (SDMT) in persons with SCI compared to matched nonSCI controls...
August 16, 2018: Journal of Neurotrauma
Wei-Wei Hao, Su-Li Zhang, Yan Sun, Li-Na Bai, Jing-Wei Bian, Hai-Cun Yu, Xiao-Chen Yin, Peng-Li Wang, Hui-Rong Liu
Myocardial fibrosis (MF) is an important pathological process of cardiac remodeling in patients with heart failure; however its etiology has not been clear. It has been known that the angiotensin II type 1 receptor autoantibody (AT1-AA) is present in patients with heart failure, but it is unclear whether this antibody directly causes MF. In this study, we investigated the role of AT1-AA in MF and its effects on cardiac fibroblasts (CFs). The AT1-AA positive rat model was established by active immunization method, and the measurement of indexes were made in the 8th week after active immunity...
August 25, 2018: Sheng Li Xue Bao: [Acta Physiologica Sinica]
Bing Han, Qingli Wang
Pulmonary hypertension due to left heart disease (PH-LHD) is caused by left ventricular (LV) systolic and/or diastolic dysfunction and left heart valve disease. LV diseases lead to left ventricular filling pressure increases, pulmonary venous obstruction and pulmonary venous pressure increases, and thus to secondary PH. Exercise tolerance is lower and fatality rates are higher in patients with PH-LHD than those in subjects with normal pulmonary arterial pressure. In spite of the progress in the study of the mechanisms of PH-LHD in recent years, no specific treatment is currently available...
August 2018: Experimental and Therapeutic Medicine
I Tong Mak, Joanna J Chmielinska, Christopher F Spurney, William B Weglicki, Jay H Kramer
Chronic effects of a combination antiretroviral therapy (cART = tenofovir/emtricitatine + atazanavir/ritonavir) on systemic and cardiac oxidative stress/injury in HIV-1 transgenic (Tg) rats and protection by Mg-supplementation were assessed. cART (low doses) elicited no significant effects in normal rats, but induced time-dependent oxidative/nitrosative stresses: 2.64-fold increased plasma 8-isoprostane, 2.0-fold higher RBC oxidized glutathione (GSSG), 3.2-fold increased plasma 3-nitrotyrosine (NT), and 3-fold elevated basal neutrophil superoxide activity in Tg rats...
August 15, 2018: International Journal of Molecular Sciences
Friederike Lindemann, David Kuerten, Eva Koch, Matthias Fuest, Claudia Fischer, Andreas Voss, Niklas Plange
PURPOSE: Vascular dysfunction and ischemia are believed to play an important part in the pathogenesis of glaucoma and especially of normal tension glaucoma (NTG). The aim of the present study was to analyze the blood pressure (BP) and heart rate variability patterns in patients with primary open-angle glaucoma (POAG) and NTG compared with controls. METHODS: In total, 37 patients with POAG, 27 patients with NTG, and 82 control subjects were included in a prospective clinical validation study...
August 15, 2018: Current Eye Research
Peter Blomstrand, Peter Sjöblom, Mats Nilsson, Magnus Wijkman, Martin Engvall, Toste Länne, Fredrik H Nyström, Carl Johan Östgren, Jan Engvall
AIMS: Obesity is associated with type 2 diabetes mellitus, left ventricular diastolic dysfunction and heart failure but it is unclear to which extent it is related to left ventricular systolic dysfunction. The aim of the study was to explore the effects of overweight and obesity on left ventricular systolic function in patients with type 2 diabetes mellitus and a control group of non-diabetic persons. METHODS: We prospectively investigated 384 patients with type 2 diabetes mellitus, and 184 controls who participated in the CARDIPP and CAREFUL studies...
August 14, 2018: Cardiovascular Diabetology
Svenja Dannewitz Prosseda, Xuefei Tian, Kazuya Kuramoto, Mario Boehm, Deepti Sudheendra, Kazuya Miyagawa, Fan Zhang, David Solow-Cordero, Joshua C Saldivar, Eric D Austin, James E Loyd, Lisa Wheeler, Adam Andruska, Michele Donato, Lingli Wang, Kay Huebner, Ross J Metzger, Purvesh Khatri, Edda Spiekerkoetter
RATIONALE: Pulmonary arterial hypertension (PAH) is characterized by progressive narrowing of pulmonary arteries resulting in right heart failure and death. Bone Morphogenetic Protein Receptor type-2 (BMPR2) mutations account for most familial PAH (FPAH) forms while reduced BMPR2 is present in many idiopathic PAH (IPAH) forms, suggesting dysfunctional BMPR2 signaling to be a key feature of PAH. Modulating BMPR2 signaling is therapeutically promising, yet how BMPR2 is downregulated in PAH is unclear...
August 14, 2018: American Journal of Respiratory and Critical Care Medicine
Michael DiLorenzo, Wei-Ting Hwang, Elizabeth Goldmuntz, Bonnie Ky, Laura Mercer-Rosa
BACKGROUND: Right ventricular (RV) systolic dysfunction has been associated with adverse outcomes in tetralogy of Fallot (TOF). However, the role and etiology of diastolic dysfunction remain incompletely defined. We assessed the association between traditional echocardiographic measures of diastolic function with catheter-based RV end-diastolic pressure (RVEDP) and identified clinical characteristics independently associated with diastolic dysfunction. METHODS: Single-center, retrospective cohort study of surgically repaired TOF patients undergoing cardiac catheterization with echocardiograms within 3 months prior to the catheterization...
August 13, 2018: Echocardiography
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