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Systolic dysfunction

Kristof Vandekerckhove, Kathleen De Waele, Aurelie Minne, Ilse Coomans, Katya De Groote, Joseph Panzer, Catherine Dhooge, Victoria Bordon, Daniel De Wolf, Jan Boone
BACKGROUND: Physical fitness is an important determinant of quality of life (QOL) after hematopoietic stem cell transplantation. Cardiac function can influence exercise performance. The aim of this study was to assess these factors and their interrelationship. PROCEDURE: Children underwent cardiopulmonary exercise testing (CPET) at least 1 year after hematopoietic stem cell transplantation (HSCT) and were compared with healthy controls. Systolic and diastolic heart function and left ventricle (LV) wall dimensions were measured...
October 14, 2018: Pediatric Blood & Cancer
Jessica Sabbatine Chimini, Jose Sergio Possomato-Vieira, Maria Luiza Santos da Silva, Carlos A Dias-Junior
preeclampsia and hypertensive disorders of pregnancy are frequently associated with feto-placental growth restriction and that may be triggered by angiogenic imbalance and endothelial dysfunction. Impaired nitric oxide (NO) bioavailability seems to be involved in these pathophysiological changes observed in hypertensive pregnancy. Pravastatin has shown efficacy and to be safe during hypertension in pregnancy. However, NO involvement in pravastatin effects during maternal hypertension and feto-placental development is unclear...
October 14, 2018: Basic & Clinical Pharmacology & Toxicology
Miguel Guerra, Adelino F Leite-Moreira
Intraventricular pressure gradients (IVPGs) play a physiological role in normal filling and emptying of the left ventricle. Regional alterations in IVPGs might be an important factor in the characteristic changes that occur in intraventricular flow in specific cardiac disorders and may contribute to and represent an early sign of ventricular dysfunction. Diastolic IVPGs, a marker of normal ventricular filling, and systolic IVPGs, a marker of normal ventricular emptying, can be attenuated, lost entirely or even reversed when ventricular emptying is opposed by afterload elevations, after regional acute ischaemia and in failing hearts...
January 2018: Revista Portuguesa de Cirurgia Cardio-torácica e Vascular
Kotb Abbass Metwalley, Hekma Saad Farghaly, Abdelrahman Abdelhamid
BACKGROUND/AIMS: Homocysteine is an important and independent risk factor for atherosclerotic diseases. The aim of this study was to evaluate serum levels of homocysteine in children with congenital adrenal hyperplasia (CAH) and their relation to carotid artery intima-media thickness (CA-IMT) and left ventricular (LV) function. METHODS: This study included 36 children with classic CAH and 36 healthy children. All underwent anthropometric evaluation. Measurement of serum levels of total homocysteine was carried out...
October 12, 2018: Hormone Research in Pædiatrics
Gianluca Di Bella, Scipione Carerj, Antonino Recupero, Rocco Donato, Pietro Pugliatti, Gabriella Falanga, Stefano Pedri, Giampiero Vizzari, Mariapaola Campisi, Concetta Zito, Cesare de Gregorio
BACKGROUND: The aim of present study was to assess left ventricular (LV) myocardial deformation and changes over time in patients with acute myocarditis (AM) with preserved ejection fraction detected by late gadolinium enhancement (LGE) magnetic resonance imaging. METHODS: Thirty-five male patients with AM diagnoses and preserved systolic function based on cardiac magnetic resonance imaging (MRI) were prospectively enrolled. On admission, echocardiography with measurements of global and segmental longitudinal (LS) strains was performed both at the endocardial (ENDO) and epicardial (EPI) levels...
October 12, 2018: Echocardiography
R Sobhy, M Samir, G Abdelmohsen, H Ibrahim, M Y Abd El Rahman, N Abdelrahman, N Behairy, O Imam, H Hamza
Rheumatic heart disease (RHD) is a major cause of morbidity and mortality in developing countries, so early diagnosis and treatment can reduce morbidity and mortality resulting from subsequent valvular damage. The aim of this study was to detect subtle myocardial dysfunction among children with RHD with preserved left ventricular systolic function. This is a cross-sectional case-control study that was conducted on 30 children with RHD (who had valvular affection of any degree and were not in activity) compared to 23 healthy children...
October 12, 2018: Pediatric Cardiology
Hironobu Kobayashi, Katsunori Fujii, Masayo Kobayashi, Naoki Saito, Kentaro Okunushi, Ryota Ebata, Tadashi Shiohama, Daisuke Sawada, Naoki Shimojo
BACKGROUND: Peripheral facial nerve palsy is characterized by unilateral facial paresis due to ipsilateral facial nerve dysfunction. Most cases are idiopathic; however, some have specific etiologies, such as herpesvirus infection, immunological disorders, and hypertension. Atomoxetine is a norepinephrine reuptake inhibitor that is used in the treatment of attention deficit hyperactivity disorder (ADHD). This drug is known to cause adverse effects, such as nausea, appetite loss, headache, insomnia, and hypertension...
October 9, 2018: Brain & Development
F Aboukhoudir, S Rekik, M Pansieri, P Obert
OBJECTIVE: The aim of this study is to assess the association between epicardial adipose tissue (EAT) and infraclinical myocardial dysfunction detected by strain imaging in diabetic patients (T2DM) with poor glycemic control. METHODS: 22 patients with T2DM and 22 healthy control subjects of similar age and sex were prospectively recruited. Echocardiographic parameters were investigated. RESULTS: In comparison to controls, diabetic patients had significantly higher body mass index (27...
October 9, 2018: Annales de Cardiologie et D'angéiologie
David Kain, Amos J Simon, Avraham Greenberg, Danny Ben Zvi, Boris Gilburd, Jacob Schneiderman
BACKGROUND: Acute MI induces leptin expression in the heart, however the role of myocardial leptin in cardiac ischemia and reperfusion (IR) remains unknown. To shed light on the effects of elevated levels of leptin in the myocardium, we overexpressed cardiac leptin and assessed local remodeling and myocardial function in this context. METHODS AND RESULTS: Cardiac leptin overexpression was stimulated in mice undergoing IR by a single intraperitoneal injection of leptin antagonist (LepA)...
2018: PloS One
Gee Hee Kim, Jung Sun Cho, Woo-Baek Chung, Chan Seok Park, Sang Hyun Ihm
Left atrial (LA) strain is known to exhibit an early progressive reduction in hypertensive patients with diastolic dysfunction. However, an association of the renin-angiotensin-*aldosterone system (RAAS) with LA deformation has not been found in these patients. We aimed to investigate the association of plasma aldosterone concentration (PAC) and 24-hour ambulatory blood pressure monitoring (ABPM) with LA and left ventricle (LV) deformation in never-treated early hypertensive patients. This cross-sectional study included 101 never-treated subjects who were registered in a working group at The Catholic University of Korea...
October 12, 2018: Clinical and Experimental Hypertension: CHE
Ju-Hee Lee, Jae-Hyeong Park
Right ventricular (RV) systolic dysfunction has been identified as an independent prognostic marker of many cardiovascular diseases. However, there are problems in measuring RV systolic function objectively and identification of RV dysfunction using conventional echocardiography. Strain echocardiography is a new imaging modality to measure myocardial deformation. It can measure intrinsic myocardial function and has been used to measure regional and global left ventricular (LV) function. Although the RV has different morphologic characteristics than the LV, strain analysis of the RV is feasible...
September 2018: Journal of cardiovascular imaging
Yuanbo Feng, Bianca Hemmeryckx, Liesbeth Frederix, Marleen Lox, Jun Wu, Ward Heggermont, Hua Rong Lu, David Gallacher, Raymond Oyen, H Roger Lijnen, Yicheng Ni
Background: An experimental imaging platform for longitudinal monitoring and evaluation of cardiac morphology-function changes has been long desired. We sought to establish such a platform by using a rabbit model of reperfused myocardial infarction (MI) that develops chronic left ventricle systolic dysfunction (LVSD) within 7 weeks. Methods: Fifty-five New Zeeland white (NZW) rabbits received sham-operated or 60-min left circumflex coronary artery (LCx) ligation followed by reperfusion...
September 2018: Quantitative Imaging in Medicine and Surgery
Juliana Valente Francica Grilletti, Katia Bilhar Scapini, Nathalia Bernardes, Jaqueline Spadari, Aline Bigongiari, Flavia de Andrade E Souza Mazuchi, Erico Chagas Caperuto, Iris Callado Sanches, Bruno Rodrigues, Kátia De Angelis
OBJECTIVES: Acute post-stroke patients present cardiovascular autonomic dysfunction, which manifests as lower heart rate variability and impaired baroreflex sensitivity. However, few studies performed to date have evaluated cardiovascular autonomic function in chronic post-stroke patients. The aim of this study was to evaluate cardiovascular autonomic modulation in chronic post-ischemic stroke patients. METHODS: The seventeen enrolled subjects were divided into a stroke group (SG, n=10, 5±1 years after stroke) and a control group (CG, n=7)...
October 8, 2018: Clinics
Stephen Tomlinson, John Atherton, Sandhir Prasad
A 24-year-old female with a diagnosis of primary carnitine deficiency, a rare inherited metabolic disorder predominantly described in the paediatric literature that causes cardiomyopathy, presented for evaluation after three months of nonadherence with prescribed carnitine therapy. Initial echocardiography demonstrated severe left ventricular dilation (104 ml/m2 ) (normal < 76 ml/m2 ) with moderate systolic dysfunction (ejection fraction 40%) and severe right ventricular dilation with mild systolic dysfunction...
2018: Case Reports in Cardiology
Mitra Sadeghi, Tal M Hörer, Daniel Forsman, Emanuel M Dogan, Kjell Jansson, Csaba Kindler, Per Skoog, Kristofer F Nilsson
BACKGROUND: Resuscitative endovascular balloon occlusion of the aorta (REBOA) is an effective adjunct in exsanguinating torso hemorrhage, but causes ischemic injury to distal organs. The aim was to investigate whether blood pressure targeting by partial REBOA (pREBOA) is possible in porcine severe hemorrhagic shock and to compare pREBOA and total REBOA (tREBOA) regarding hemodynamic, metabolic and inflammatory effects. METHODS: Eighteen anesthetized pigs were exposed to induced controlled hemorrhage to a systolic blood pressure (SBP) of 50 mmHg and randomized into three groups of thoracic REBOA: 30 min of pREBOA (target SBP 80-100 mmHg), tREBOA, and control...
September 29, 2018: Injury
A Tiritilli, A Tritar, K Rehal, P Iaria, T Benali, A S Olezac, S Sayah, R Codjia, P M Barhoum, P Viard, P Aouate
Since its first description in Japan in 1990, Takotsubo (stress) cardiomyopathy has gained worldwide recognition. The disease is characterized by transient systolic and diastolic left ventricular dysfunction with a variety of wall-motion abnormalities. She predominantly affects elderly women and she is often preceded by an emotional or physical trigger. In the acute phase, the clinical presentation, electrocardiographic findings and biomarker profiles are often similar to those of an acute coronary syndrome...
October 6, 2018: Annales de Cardiologie et D'angéiologie
Hilal Erken Pamukcu, Demet Menekşe Gerede Uludağ, Bahar Tekin Tak, Mine Hayriye Sorgun, Tolga Han Efe, Aynur Acıbuca, Cenk Akbostancı, Sibel Turhan
OBJECTIVE: Parkinson's disease (PD) is a neurological disorder, and ergot dopamine agonists (DAs) are no longer usually preferred in the treatment due to the increased risk of valvular heart disease. Some recent studies have shown that commonly used non-ergot DA also increases the risk of heart failure. On the other hand, there are studies showing conflicting data about this relationship. The aim of the present study was to investigate the cardiac effects of non-ergot DAs in patients with PD using echocardiography...
October 2018: Anatolian Journal of Cardiology
Jennifer A Cowger, Gillian Grafton
Severe systolic dysfunction combined with symptoms of heart failure has a high rate of morbidity and mortality. Medical management remains the mainstay of therapy but mechanical circulatory support (MCS) is one of the treatment options for end-stage heart failure. The left ventricular assist device (LVAD) is the most common type of device used for durable MCS. There have been significant improvements in the technology, surgical technique, and patient management. There is not a single model that is able to accurately assess risk in these patients due to the variety of variables...
November 2018: Cardiology Clinics
Qionglin Zhou, Linxi Chen, Mingzhu Tang, Yu Guo, Lanfang Li
Apelin, an endogenous ligand for the G protein-coupled receptor APJ, is widely expressed in various organs. Recent research has indicated that the Apelin/APJ system plays an important role in aging. Apelin and APJ receptor expression are down-regulated with increasing age. In murine models, Apelin and APJ knockouts exhibit accelerated senescence whereas Apelin-restoration results in enhanced vigor and rejuvenated behavioral and circadian phenotypes. Furthermore, aged Apelin knockout mice develop progressive impairment of cardiac contractility associated with systolic dysfunction...
October 5, 2018: Clinica Chimica Acta; International Journal of Clinical Chemistry
Manuela Bonizzoli, Simone Cipani, Chiara Lazzeri, Marco Chiostri, Piercarlo Ballo, Armando Sarti, Adriano Peris
PURPOSE: Speckle tracking echocardiography is a novel echocardiographic technique to assess RV myocardial function but no data are so far available in patients with acute respiratory distress syndrome (ARDS), and we aimed at assessing the feasibility of 2 dimensional (2D) speckle tracking echocardiography and the prognostic role of RV free wall speckle tracking strain in 30 consecutive patients with moderate-severe ARDS MATERIALS AND METHODS: In an observational prospective study, 30 consecutive patients with moderate-severe ARDS were enrolled...
October 8, 2018: Echocardiography
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