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https://www.readbyqxmd.com/read/30547036/alternative-splicing-regulator-rbm20-and-cardiomyopathy
#1
REVIEW
Takeshi Watanabe, Akinori Kimura, Hidehito Kuroyanagi
RBM20 is a vertebrate-specific RNA-binding protein with two zinc finger (ZnF) domains, one RNA-recognition motif (RRM)-type RNA-binding domain and an arginine/serine (RS)-rich region. RBM20 has initially been identified as one of dilated cardiomyopathy (DCM)-linked genes. RBM20 is a regulator of heart-specific alternative splicing and Rbm20 Δ RRM mice lacking the RRM domain are defective in the splicing regulation. The Rbm20 Δ RRM mice, however, do not exhibit a characteristic DCM-like phenotype such as dilatation of left ventricles or systolic dysfunction...
2018: Frontiers in Molecular Biosciences
https://www.readbyqxmd.com/read/30545453/associations-of-body-mass-and-fat-indexes-with-cardiometabolic-traits
#2
Joshua A Bell, David Carslake, Linda M O'Keeffe, Monika Frysz, Laura D Howe, Mark Hamer, Kaitlin H Wade, Nicholas J Timpson, George Davey Smith
BACKGROUND: Body mass index (BMI) is criticized for not distinguishing fat from lean mass and ignoring fat distribution, leaving its ability to detect health effects unclear. OBJECTIVES: The aim of this study was to compare BMI with total and regional fat indexes from dual-energy x-ray absorptiometry in their associations with cardiometabolic traits. Duration of exposure to and change in each index across adolescence were examined in relation to detailed traits in young adulthood...
December 18, 2018: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/30545377/assessment-of-right-atrium-dysfunction-in-patients-with-obstructive-sleep-apnea-syndrome-using-velocity-vector-imaging
#3
Junfang Li, Changhong Lu, Wugang Wang, Kun Gong, Liang Zhao, Zhibin Wang
BACKGROUND AND OBJECTIVES: This study aimed to assess the changes of RA function in patients with obstructive sleep apnea syndrome (OSAS) using velocity vector imaging (VVI) and to evaluate the application of VVI technology. METHODS: According to the apnea-hypopnea index (AHI), 71 patients with OSAS were divided into three groups: mild, moderate, and severe. A total of 30 cases of healthy subjects were enrolled as the control group. Digital images of apex four-chamber views were acquired to measure the right atrium (RA) linear dimensions and volume parameters including RA longitudinal diameter (RAL), transverse diameter (RAT), RA maximum volume (Vmax), RA minimum volume (Vmin), right atrial volume before contraction (Vpre)...
December 13, 2018: Cardiovascular Ultrasound
https://www.readbyqxmd.com/read/30543808/right-ventricular-functional-reserve-in-early-stage-idiopathic-pulmonary-fibrosis-an-exercise-two-dimensional-speckle-tracking-doppler-echocardiography-study-on-behalf-of-the-right-heart-international-network-right-net-investigators
#4
Antonello D'Andrea, Anna Agnese Stanziola, Rajan Saggar, Rajeev Saggar, Simona Sperlongano, Marianna Conte, Michele D'Alto, Francesco Ferrara, Luna Gargani, Patrizio Lancellotti, Eduardo Bossone
BACKGROUND: The most important determinant of long term survival in idiopathic pulmonary fibrosis (IPF) patients is the adaptation of the right ventricle (RV) to the increased pulmonary vascular resistance. Our aim was to explore RV contractile reserve during stress echocardiography (SE) in early stage IPF. METHODS: 50 early stage IPF patients and 50 healthy controls underwent rest and SE, including RV 2-dimensional Speckle Tracking Echocardiography (2DSTE). At peak exertion blood gas analysis and spirometry were also assessed...
December 10, 2018: Chest
https://www.readbyqxmd.com/read/30539717/the-incremental-value-of-right-ventricular-size-and-strain-in-the-risk-assessment-of-right-heart-failure-post-left-ventricular-assist-device-implantation
#5
Marie Aymami, Myriam Amsallem, Jackson Adams, Karim Sallam, Kegan Moneghetti, Matthew Wheeler, William Hiesinger, Jeffrey Teuteberg, Dana Weisshaar, Jean-Philippe Verhoye, Y Joseph Woo, Richard Ha, François Haddad, Dipanjan Banerjee
BACKGROUND: Right heart failure (RHF) after left ventricular assist device (LVAD) implantation is associated with high morbidity and mortality. Existing risk scores include semiquantitative evaluation of right ventricular (RV) dysfunction. This study aimed to determine whether quantitative evaluation of both RV size and function improve risk stratification for RHF after LVAD implantation beyond validated scores. METHODS AND RESULTS: From 2009 to 2015, 158 patients who underwent implantation of continuous-flow devices who had complete echocardiographic and hemodynamic data were included...
December 2018: Journal of Cardiac Failure
https://www.readbyqxmd.com/read/30537108/impaired-pressure-natriuresis-and-non-dipping-blood-pressure-in-rats-with-early-type-1-diabetes-mellitus
#6
Geoffrey J Culshaw, Hannah M Costello, David Binnie, Kevin R Stewart, Alicja Czopek, Neeraj Dhaun, Patrick W F Hadoke, David J Webb, Matthew A Bailey
KEY POINTS SUMMARY: Type 1 diabetes mellitus increases cardiovascular risk: hypertension amplifies this risk. Pressure natriuresis regulates long-term blood pressure. We induced type 1 diabetes in rats by streptozotocin injection and after three weeks demonstrated a substantial impairment of pressure natriuresis: acute increases in blood pressure did not increase renal medullary blood flow, and tubular sodium reabsorption was not downregulated. Proximal tubule sodium reabsorption, measured by lithium clearance, was unaffected...
December 7, 2018: Journal of Physiology
https://www.readbyqxmd.com/read/30537022/implantable-cardiac-defibrillators-for-people-with-non-ischaemic-cardiomyopathy
#7
REVIEW
Mohamad El Moheb, Johny Nicolas, Assem M Khamis, Ghida Iskandarani, Elie A Akl, Marwan Refaat
BACKGROUND: There is evidence that implantable cardioverter-defibrillator (ICD) for primary prevention in people with an ischaemic cardiomyopathy improves survival rate. The evidence supporting this intervention in people with non-ischaemic cardiomyopathy is not as definitive, with the recently published DANISH trial finding no improvement in survival rate. A systematic review of all eligible studies was needed to evaluate the benefits and harms of using ICDs for primary prevention in people with non-ischaemic cardiomyopathy...
December 8, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/30536946/irak3-gene-silencing-prevents-cardiac-rupture-and-ventricular-remodeling-through-negative-regulation-of-the-nf-%C3%AE%C2%BAb-signaling-pathway-in-a-mouse-model-of-acute-myocardial-infarction
#8
Zhen-Wei Ge, Bao-Cai Wang, Jun-Long Hu, Jun-Jie Sun, Sheng Wang, Xian-Jie Chen, Shu-Ping Meng, Lin Liu, Zhao-Yun Cheng
Cardiac rupture and ventricular remodeling are recognized as the severe complications and major risk factors of acute myocardial infarction (AMI). This study aims to evaluate the regulatory roles of interleukin-1 receptor-associated kinase 3 (IRAK3) and nuclear factor-κB (NF-κB) signaling pathway in cardiac rupture and ventricular remodeling. Microarray analysis was performed to screen AMI-related differentially expressed genes and IRAK3 was identified. The models of AMI were established in male C57BL/6 mice to investigate the functional role of IRAK3...
December 7, 2018: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/30536153/heart-involvement-in-patients-with-myotonic-dystrophy-type-2
#9
Stojan Peric, Bogdan Bjelica, Ksenija Aleksic, Masa Kovacevic, Edita Cvitan, Gorana Mandic Stojmenovic, Vidosava Rakocevic Stojanovic
Myotonic dystrophy type 2 (DM2) is a slowly progressive, autosomal-dominant disease. This is a multisystemic disorder that affects the heart, which is one of the main causes of morbidity and mortality in DM2. The aim of the study was to define cardiac impairments in patients with DM2 and its association with sociodemographic and clinical features of patients. This retrospective study comprised 62 adult patients with DM2 hospitalized at the Neurology Clinic, Clinical Center of Serbia from 2013 until 2018, who underwent electrocardiography (ECG) and echocardiography examinations...
December 7, 2018: Acta Neurologica Belgica
https://www.readbyqxmd.com/read/30534860/-predictive-value-of-dipyridamole-myocardial-perfusion-tomography-on-survival
#10
Luis Alarcón, Matías Rau, Hernán Prat, René Fernández, Jaime Carmona, Juan P Zhindon, Javiera González, Teresa Massardo
BACKGROUND: Dipyridamole (DIP) is the most commonly employed pharmacological stressor for myocardial perfusion tomography (SPECT) in patients unable to reach an adequate work load. AIM: To assess the predictive capacity of DIP SPECT on survival. MATERIAL AND METHODS: We included 985 adults aged 66 ±11 years (45% women) with rest and DIP-SPECT. The main indications for the procedure were coronary artery disease (CAD) screening in 66% and known CAD in 33%...
August 2018: Revista Médica de Chile
https://www.readbyqxmd.com/read/30533002/pre-operative-right-ventricular-echocardiographic-parameters-associated-with-short-term-outcomes-and-long-term-mortality-after-cabg
#11
Mohammed Andaleeb Chowdhury, Jered M Cook, George V Moukarbel, Sana Ashtiani, Thomas A Schwann, Mark R Bonnell, Christopher J Cooper, Samer J Khouri
Background This analysis aims to assess the prognostic value of pre-operative right ventricular echocardiographic parameters in predicting short-term adverse outcomes and long-term mortality after coronary artery bypass graft (CABG). Methods Study design: Observational retrospective cohort. Pre-operative echocardiographic data, perioperative adverse outcomes (POAO) and long-term mortality were retrospectively analyzed in 491 patients who underwent isolated CABG at a single academic center between 2006 and 2014...
December 1, 2018: Echo Research and Practice
https://www.readbyqxmd.com/read/30531727/invasive-hemodynamic-monitoring-of-aortic-and-pulmonary-artery-hemodynamics-in-a-large-animal-model-of-ards
#12
Rahel Kluttig, Till Friedheim, Christoph Behem, Niko Zach, Rosannis Brown, Michael Graessler, Daniel Reuter, Christian Zöllner, Constantin Trepte
One of the leading causes of morbidity and mortality in patients with heart failure is right ventricular (RV) dysfunction, especially if it is due to pulmonary hypertension. For a better understanding and treatment of this disease, precise hemodynamic monitoring of left and right ventricular parameters is important. For this reason, it is essential to establish experimental pig models of cardiac hemodynamics and measurements for research purpose. This article shows the induction of ARDS by using oleic acid (OA) and consequent right ventricular dysfunction, as well as the instrumentation of the pigs and the data acquisition process that is needed to assess hemodynamic parameters...
November 26, 2018: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/30528627/haemodynamic-effects-of-pharmacologic-stress-with-adenosine-in-patients-with-left-ventricular-systolic-dysfunction
#13
Gaurav S Gulsin, Ahmed M S E K Abdelaty, Abhishek Shetye, Florence Y Lai, Amrita Bajaj, Indrajeet Das, Aparna Deshpande, Praveen P G Rao, Jeffrey Khoo, Gerry P McCann, Jayanth R Arnold
BACKGROUND: In patients with heart failure, downregulation of adenosine receptor gene expression and impaired adenosine-related signal transduction may result in a diminished response to adenosine. This may have implications for cardiac stress testing. We evaluated the haemodynamic response to intravenous adenosine in patients with left ventricular systolic dysfunction (LVSD) undergoing stress cardiovascular magnetic resonance imaging (CMR). METHODS AND RESULTS: We retrospectively examined 497 consecutive patients referred for clinical stress CMR...
December 4, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/30527529/the-role-of-cd27-cd70-signaling-in-myocardial-infarction-and-cardiac-remodeling
#14
Wei Li, Fengxiao Zhang, Chenhui Ju, Suying Lv, Kai Huang
BACKGROUND: CD4+ T cells are key players in regulating the inflammatory processes and physiological repair mechanisms engaged after acute myocardial infarction (AMI). Although signaling through the CD27-CD70 co-stimulatory pathway are known to be important in CD4+ T cell activation and proliferation in certain contexts, the role of the CD27-CD70 pathway in AMI remains unclear. METHODS AND RESULTS: A total of 43 control subjects, 42 unstable angina patients, and 90 AMI patients were enrolled in the present study...
December 3, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/30527346/post-systolic-shortening-predicts-heart-failure-following-acute-coronary-syndrome
#15
Philip Brainin, Kristoffer Grundtvig Skaarup, Allan Zeeberg Iversen, Peter Godsk Jørgensen, Elke Platz, Jan Skov Jensen, Tor Biering-Sørensen
BACKGROUND: Post-systolic shortening (PSS) is a novel echocardiographic marker of myocardial dysfunction. Our objective was to assess the prognostic value of PSS in patients following acute coronary syndrome (ACS) who underwent percutaneous coronary intervention (PCI). METHODS: A total of 428 patients hospitalized for ACS (mean age 64 ± 12 years, male 73%) underwent speckle tracking echocardiography following treatment with PCI (median 2 days). The individual endpoints were heart failure (HF), myocardial infarction (MI) and all-cause death...
November 22, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/30526955/cardiovascular-images-vascular-hamartoma-of-the-mitral-valve-in-a-horse
#16
M J DiVincenzo, J D Bonagura, L Rings, T A Burns, R E Cianciolo, R Kohnken
An 8-month-old Hanoverian gelding was presented with a history of cardiac murmurs that were not apparent as a foal nor reported at the time of castration. Major echocardiographic findings included mitral valvular thickening, functional stenosis, and mitral regurgitation of sufficient severity to cause diastolic and systolic cardiac murmurs, left-sided volume overload, and pulmonary hypertension. Due to the hemodynamic severity of the lesion and poor prognosis for future performance and longevity, euthanasia was elected...
December 2018: Journal of Veterinary Cardiology: the Official Journal of the European Society of Veterinary Cardiology
https://www.readbyqxmd.com/read/30526268/associations-of-echocardiography-markers-and-vascular-brain-lesions-the-aric-study
#17
Michelle C Johansen, Amil M Shah, Seth T Lirette, Michael Griswold, Thomas H Mosley, Scott D Solomon, Rebecca F Gottesman
Background Associations between subtle changes in cardiac and cerebral structure and function are not well understood, with some studies suggesting that subclinical cardiac changes may be associated with markers of vascular brain insult. Methods and Results Data from the ARIC (Atherosclerosis Risk in Communities) Study (5th ARIC visit; 2011-2013; N=1974) were used to explore relationships between abnormalities of cardiac structure/function and subclinical brain disease and to test specific associations between those cardiac and vascular brain changes that share a common mechanism...
December 18, 2018: Journal of the American Heart Association
https://www.readbyqxmd.com/read/30525316/adropin-and-irisin-new-biomarkers-of-cardiac-status-in-patients-with-end-stage-renal-disease-a-preliminary-study
#18
Małgorzata Kałużna, Krzysztof Pawlaczyk, Krzysztof Schwermer, Krzysztof Hoppe, Magdalena Człapka-Matyasik, Aisha Yusuf Ibrahim, Nadia Sawicka-Gutaj, Andrzej Minczykowski, Katarzyna Ziemnicka, Andrzej Oko, Marek Ruchała
BACKGROUND: The new polypeptide hormones adropin and irisin have a broad impact on human metabolism and energy homeostasis. They could be potential biomarkers of cardiac injury. In end-stage renal disease (ESRD), the clinical importance of adropin and irisin is yet to be investigated. OBJECTIVES: The aim of this study was to determine the relationship between these peptides and cardiac status in ESRD patients. MATERIAL AND METHODS: Seventy-nine ESRD patients on hemodialysis (HD), peritoneal dialysis (PD) or after renal transplantation (Tx), and 40 healthy, ageand sex-matched controls (CON) were included in this study...
December 7, 2018: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/30522384/standardizing-the-use-of-albumin-in-large-volume-paracentesis
#19
Shelby S Anderson, Julian B McCreary, Kristin S Alvarez, L Steven Brown, Deepak Agrawal
BACKGROUND: Albumin after large volume paracentesis (LVP) reduces paracentesis-induced circulatory dysfunction (PICD). The most efficacious dose of albumin for LVP is unclear. OBJECTIVE: To evaluate the impact of implementing a standardized LVP order set on albumin utilization and patient outcomes. METHODS: This is a retrospective review of patients with ascites due to cirrhosis who received a therapeutic paracentesis at a large, academic institution...
December 6, 2018: Journal of Pharmacy Practice
https://www.readbyqxmd.com/read/30517648/left-atrial-function-in-heart-failure-with-mid-range-ejection-fraction-differs-from-that-of-heart-failure-with-preserved-ejection-fraction-a-2d-speckle-tracking-echocardiographic-study
#20
Lamia Al Saikhan, Alun D Hughes, Wing-See Chung, Maryam Alsharqi, Petros Nihoyannopoulos
Aims: Heart failure (HF) with mid-range ejection fraction (HFmrEF) shares similar diagnostic criteria to HF with preserved ejection fraction (HFpEF). Whether left atrial (LA) function differs between HFmrEF and HFpEF is unknown. We, therefore, used 2D-speckle-tracking echocardiography (2D-STE) to assess LA phasic function in patients with HFpEF and HFmrEF. Methods and results: Consecutive outpatients diagnosed with HF according to current European recommendations were prospectively enrolled...
December 4, 2018: European Heart Journal Cardiovascular Imaging
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