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Hematology and Oncology

J Lubega, G Airewele, E Frugé, K Wilson-Lewis, E Ishigami, M Cubbage, P Waswa, J Kambugu, C E Allen, J Slone, P S Mehta, D G Poplack
No abstract text is available yet for this article.
November 30, 2018: Blood Advances
Frank S Lieberman, Meihua Wang, H Ian Robins, Christina I Tsien, Walter J Curran, Maria Werner-Wasik, Ryan P Smith, Christopher Schultz, Alan C Hartford, Peixin Zhang, Minesh P Mehta
PURPOSE: Evaluate the toxicity and efficacy of adjuvant temozolomide (TMZ) and irinotecan (CPT-11) for 12 months following concurrent chemo-radiation in newly diagnosed glioblastoma (GBM). METHODS: Trial XXXX, a single arm, multi-institutional phase 2 trial was designed to determine the efficacy and toxicity of concomitant TMZ and radiation (RT) followed by adjuvant TMZ combined with CPT-11 given for 12 cycles compared to historical controls of adjuvant TMZ alone given for 6 cycles...
November 26, 2018: International Journal of Radiation Oncology, Biology, Physics
Suanna S Bruinooge, Todd A Pickard, Wendy Vogel, Amy Hanley, Caroline Schenkel, Elizabeth Garrett-Mayer, Eric Tetzlaff, Margaret Rosenzweig, Heather Hylton, Shannon N Westin, Noël Smith, Conor Lynch, Michael P Kosty, Stephanie F Williams
PURPOSE: Advanced practice providers (APPs, which include NPs and physician assistants [PAs]) are integral members of oncology teams. This study aims first to identify all APPs in oncology and, second, to understand personal and practice characteristics (including compensation) of those APPs. METHODS: We identified APPs who practice oncology from membership and claims data. We surveyed 3,055 APPs about their roles in clinical care. RESULTS: We identified at least 5,350 APPs in oncology and an additional 5,400 who might practice oncology...
December 2018: JAAPA: Official Journal of the American Academy of Physician Assistants
Vasilios Karavasilis, Epaminontas Samantas, Georgia-Angeliki Koliou, Anna Kalogera-Fountzila, George Pentheroudakis, Ioannis Varthalitis, Helena Linardou, Grigorios Rallis, Maria Skondra, Georgios Papadopoulos, George Papatsibas, Joseph Sgouros, Athina Goudopoulou, Konstantine T Kalogeras, Christos Dervenis, Dimitrios Pectasides, George Fountzilas
BACKGROUND: The prognosis of patients with advanced pancreatic cancer is dismal, and there is a need for novel and effective treatments. OBJECTIVES: Tο determine the maximum tolerated dose (MTD) and dose-limiting toxicities (DLTs) of a novel gemcitabine (G) and temsirolimus (T) combination (phase I) and estimate the 6-month progression-free survival (PFS) in patients treated with the T + G combination (phase II). PATIENTS AND METHODS: Eligible patients with histologically confirmed inoperable or metastatic pancreatic carcinoma (MPC) were entered into the trial...
November 28, 2018: Targeted Oncology
(no author information available yet)
No abstract text is available yet for this article.
November 14, 2018: Zhonghua Xue Ye Xue za Zhi, Zhonghua Xueyexue Zazhi
Luca Falzone, Salvatore Salomone, Massimo Libra
The medical history of cancer began millennia ago. Historical findings of patients with cancer date back to ancient Egyptian and Greek civilizations, where this disease was predominantly treated with radical surgery and cautery that were often ineffective, leading to the death of patients. Over the centuries, important discoveries allowed to identify the biological and pathological features of tumors, without however contributing to the development of effective therapeutic approaches until the end of the 1800s, when the discovery of X-rays and their use for the treatment of tumors provided the first modern therapeutic approach in medical oncology...
2018: Frontiers in Pharmacology
Colleen Villamin, Jacqueline Anderson, Bryan Fellman, Diana Urbauer, Kelly Brassil
BACKGROUND: An opportunity was identified to compare perceptions of the occurrence and types of missed care at a comprehensive cancer center. PURPOSE: The purpose was to evaluate the difference in perceived occurrence and types of missed care between medical, surgical, and hematologic oncology units in the context of a newly implemented patient care delivery system, Primary Team Nursing (PTN). METHODS: A descriptive, repeated-measures design was used...
January 2019: Journal of Nursing Care Quality
Mustafa A Yoruk, Cigdem U Durakbasa, Cetin Timur, Seyma S Sahin, Esra C Taskin
In total, 74 pediatric oncology patients with hematologic malignancies (n=56) or solid tumors (n=18) and a median age of 78.5 months were included in this prospective study. The aims were to assess malnutrition risks and nutritional status over a 6-month treatment period measured at regular intervals. The rate of patients with high risk for malnutrition at diagnosis was 28.4% by Screening Tool for Risk of Impaired Nutritional Status and Growth tool and 36.5% by Pediatric Yorkhill Malnutrition Score. Body mass index (BMI) z-scores at diagnosis showed 12...
November 20, 2018: Journal of Pediatric Hematology/oncology
Hsiu-Lan Su, Li-Min Wu, Shyh-Shin Chiou, Pei-Chin Lin, Yu-Mei Liao
PURPOSE: To examine the effects of walking exercise on exercise tolerance, fatigue, sleep quality, and quality of life (QOL) for children and adolescents with cancer. METHODS: A 6-week walking exercise regimen was implemented in pediatric hematological and oncological wards and in clinics of a medical center in Taiwan. A 6-min walk test (6MWT), fatigue, sleep quality, and QOL were measured at baseline and for six subsequent weeks. RESULTS: Adherence to the walking exercise regimen was achieved by 72-89% of the participants in this study...
December 2018: European Journal of Oncology Nursing: the Official Journal of European Oncology Nursing Society
Tülin Güngör, Özlem Arman Bilir, Vildan Koşan Çulha, Ali Güngör, Abdurrahman Kara, Fatih Mehmet Azık, Hüsniye Neşe Yaralı
OBJECTIVE: Immune thrombocytopenic purpura (ITP) is the most common cause of acquired thrombocytopenia children. The aim of this retrospective study is to describe presenting features and clinical characteristics of ITP and evaluate clinical course, treatment modalities, and complications and determine the effects of preceding infection history, age, gender, treatment modality, and admission platelet count on chronicity. METHOD: Two hundred and eleven patients who were diagnosed ITP and followed-up in Department of Pediatric Hematology, Ankara Children Hematology Oncology Education and Research Hospital between January 2008 and September 2012 were included...
November 3, 2018: Pediatrics and Neonatology
G Myers
Immune checkpoint inhibitors (icis) such as inhibitors of ctla-4, PD-1, and PD-L1, given as monotherapy or combination therapy have emerged as effective treatment options for immune-sensitive solid tumours and hematologic malignancies. The benefits of icis can be offset by immune-related adverse events (iraes) that leave all organ systems vulnerable and subsequently increase the risk for morbidity and mortality. Because of fluctuating onset and prolonged duration, the toxicities associated with iraes represent a shift from the understanding of conventional anticancer toxicities...
October 2018: Current Oncology
Mona Pettersson, Anna T Höglund, Mariann Hedström
INTRODUCTION: In cancer care, do-not-resuscitate (DNR) decisions are made frequently; i.e., decisions not to start the heart in the event of a cardiac arrest. A DNR decision can be a complex process involving nurses and physicians with a wide variety of experiences and perspectives. Previous studies have shown different perceptions of the DNR decision process among nurses and physicians, e.g. concerning patient involvement and information. DNR decisions have also been reported to be unclear and documentation inconsistent...
2018: PloS One
Claas Baier, Christin Linderkamp, Andreas Beilken, Felicitas Thol, Michael Heuser, Ella Ebadi, Tina Ganzenmueller, Albert Heim, Franz-Christoph Bange
Introduction: Respiratory syncytial virus (RSV) and influenza virus infections are a significant healthcare risk for immunocompromised patients. In addition to community onset, nosocomial acquisition and transmission may also occur. Detection of asymptomatic shedders (e.g., patients in the incubation period or immunosuppressed long term shedders) facilitates control of nosocomial transmission. Methods: To strengthen the existing infection control concept, a PCR-based screening for RSV and influenza virus was implemented for all patients lacking respiratory symptoms (asymptomatic patients) who were hospitalized on an adult and a pediatric hemato-oncological ward...
2018: GMS Hygiene and Infection Control
Selma Çakmakcı, Turan Bayhan, Meriç Kaymak Cihan, İnci Ergürhan İlhan
No abstract text is available yet for this article.
September 2018: Türk Pediatri Arşivi
Mary-Haston Leary, Kathryn Morbitzer, Bobbi Jo Walston, Stephen Clark, Jenna Kaplan, Kayla Waldron, John Valgus, Chris Falato, Lindsey Amerine
BACKGROUND: Despite widespread recognition of the need for innovative pharmacy practice approaches, the development and implementation of value-based outcomes remains difficult to achieve. Furthermore, gaps in the literature persist because the majority of available literature is retrospective in nature and describes only the clinical impact of pharmacists' interventions. OBJECTIVE: Length of stay (LOS) is a clinical outcome metric used to represent efficiency in health care...
November 18, 2018: Annals of Pharmacotherapy
Laeeq Malik, David Lu
Clinical trials in oncology have become increasingly complex because of incorporation of predictive biomarkers and patient selection based on molecular profiling of tumors. We have examined the change in procedures and work intensity in phase 1 oncology trials over the years with several parameters used as surrogates of complexity. Categories that were included as events were clinical evaluations, pharmacokinetic (PK) laboratory tests, non-PK laboratory tests, specific molecular or histological characteristics, questionnaires and subjective assessments, routine clinical and physical examinations, imaging, invasive procedures and others...
November 16, 2018: Investigational New Drugs
Hamed Chaabouni, Jihène Féki, Emna Elleuch, Slim Charfi, Afef Khanfir, Nabil Toumi, Tahia Boudawara, Mounir Ben Jmea, Jamel Daoud, Mounir Frikha
INTRODUCTION: Tuberculosis (TBC) is a major public health problem with high mortality especially in developing countries. It is associated with a higher risk of developing pulmonary and non-pulmonary malignancies including solid and hematologic cancers. Association between TBC and nonpulmonary malignancies is rarely described in the literature. AIM: To describe the epidemiological, clinical, therapeutic modalities and the evolutive aspects of patients treated for cancer and TBC...
June 2018: La Tunisie Médicale
Corinna Trenker, Lisa May, Damiano Librizzi, Albrecht Neesse, Christian Görg
PURPOSE: In contrast to splenomegaly, the clinical value of a small spleen (hyposplenia) is unclear. Contrast-enhanced ultrasound (CEUS) has not been investigated systematically in hyposplenia. METHODS: Between February 2005 and January 2017, 43 patients with hyposplenia (< 7 × 3 cm) were examined by B-mode ultrasound (US) and CEUS. A retrospective data analysis was performed. RESULTS: A total of 39 (91%) patients had an underlying disease (UD; allogenic stem cell transplantation, n = 16; autoimmune-diseases, n = 7; sickle cell anemia, n = 5; solid tumors, n = 5; others, n = 6)...
November 13, 2018: Digestion
Megan Loew, Kristin Niel, Jonathan D Burlison, Kathryn M Russell, Seth E Karol, Aimee C Talleur, Leigh Ann Christy, Liza-Marie Johnson, Valerie M Crabtree
Quality problem or issue: Night-shift medical providers frequently experience limited sleep resulting in fatigue, often because of paging activity. Streamlined medical-specific communication interventions are known to improve sleep and communication among these providers. Initial assessment: We found that non-urgent paging communication occurred frequently during night-shifts, leading to provider sleep disturbances within our institution. We tested a quality improvement (QI) intervention to improve paging practices and determined its effect on provider sleep...
November 13, 2018: International Journal for Quality in Health Care
Andrea Angelini, Giulia Trovarelli, Antonio Berizzi, Elisa Pala, Anna Breda, Marco Maraldi, Pietro Ruggieri
BACKGROUND: Metastatic lesions to the proximal femur occur frequently and require special consideration due to the high risk of pathologic fractures. Type of surgery might influence patient survival considering the growing concept of oligometastases. In fact, the use of modular tumor megaprosthesis is increasing in the last decades compared to intramedullary nailing. Aim of this study was to evaluate oncological and functional results of treatment in patients with pathologic or impending fracture of the proximal femur, with patient survival being the primary, complications the secondary, and functional results the tertiary endpoint...
November 2018: Injury
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