keyword
https://read.qxmd.com/read/37982381/the-trends-in-venous-thromboembolism-occurrence-and-prevention-after-minimally-invasive-varicose-vein-surgery
#1
JOURNAL ARTICLE
Kirill Lobastov, Maria Shaldina, Athena Matveeva, Anna Kovalchuk, Denis Borsuk, Ilya Schastlivtsev, Leonid Laberko, Alexey Fokin
OBJECTIVES: To assess the trends of VTE occurrence and prevention in varicose vein surgery. METHOD: The registry-based CAPSIVS trial (NCT03041805) analysis includes results in 1878 lower limbs. The primary outcome is a 28-day symptomatic or asymptomatic DVT revealed with duplex ultrasound. RESULTS: Any DVT, including EHIT, was observed in 3.4%, while symptomatic in 0.5%. Prophylactic anticoagulation was administrated in 20.4% with LMWH (13...
November 20, 2023: Phlebology
https://read.qxmd.com/read/35903879/electrical-cardioversion-of-atrial-arrhythmias-with-cardiac-amyloidosis-in-the-era-of-direct-oral-anticogulants
#2
JOURNAL ARTICLE
Olivier Touboul, Vincent Algalarrondo, Silvia Oghina, Nathalie Elbaz, Segolene Rouffiac, David Hamon, Fabrice Extramiana, Estelle Gandjbakhch, Thomas D'Humieres, Eloi Marijon, Tarvinder S Dhanjal, Emmanuel Teiger, Thibaud Damy, Nicolas Lellouche
AIMS: Atrial fibrillation (AF)/atrial flutter is common during cardiac amyloidosis (CA). Electrical cardioversion (EC) is a strategy to restore sinus rhythm (SR). However, left atrial thrombus (LAT) represents a contraindication for EC. CA patients with AF/atrial flutter have a high prevalence of LAT. We aimed to evaluate EC characteristics, LAT prevalence and risk factors, and AF/atrial flutter outcome in CA patients undergoing EC, predominantly treated with direct oral anticoagulants (DOACs)...
July 28, 2022: ESC Heart Failure
https://read.qxmd.com/read/35476866/postoperative-bleeding-in-patients-under-direct-oral-anticoagulation-after-maxillary-sinus-floor-augmentation-a-case-control-study
#3
JOURNAL ARTICLE
Paolo Capparè, Giulia Tetè, Ottavio Alfieri, Giuseppe Pantaleo, Pietro Montemezzi
PURPOSE: The aim of this case-control study was to investigate the occurrence of bleeding events related to maxillary sinus elevation with a lateral window in patients under direct oral anticogulant therapy. MATERIALS AND METHODS: Seventyseven consecutive patients were scheduled for unilateral maxillary sinus floor elevation using a lateral window approach. Participants were divided into two groups: group A, formed by 37 patients who were under novel oral anticoagulation therapy (rivaroxaban/apixaban), and a control group, composed of 40 healthy subjects...
March 2022: International Journal of Oral & Maxillofacial Implants
https://read.qxmd.com/read/34979675/chads-2-and-cha-2-ds-2-vasc-scores-can-guide-the-evaluation-of-cryptogenic-ischemic-stroke
#4
JOURNAL ARTICLE
Esme Ekizoglu, Murat Mert Atmaca, Cagla Cinar-Balcioglu, Nilufer Yesilot, Oguzhan Coban
BACKGROUND AND AIMS: Cryptogenic ischemic strokes (CIS) are treated with antiplatelets for stroke prevention in routine clinical practice. The objective of this study was to investigate whether the CHADS2 and CHA2 DS2 -VASc scores may be used to identify the patients with CIS at higher risk of ischemic stroke despite antiplatelet therapy. MATERIAL AND METHODS: We calculated CHADS2 and CHA2 DS2 -VASc scores in patients with first ever CIS; those previously managed with antiplatelets (AP group) and in those without antiplatelets (non-AP group), using the prospectively recorded data of the Istanbul Medical School Stroke Registry from 1996-2014...
November 2021: Neurology India
https://read.qxmd.com/read/34242404/association-of-vitamin-k-and-non-vitamin-k-oral-anticogulant-use-and-cancer-incidence-in-atrial-fibrillation-patients
#5
JOURNAL ARTICLE
Adina A Iftimi, Clara L Rodríguez-Bernal, Salvador Peiró, Santiago Bonanad, Andreu Ferrero-Gregori, Isabel Hurtado, Aníbal García-Sempere, Gabriel Sanfélix-Gimeno
The association between the use of Vitamin K antagonists (VKA) and cancer risk reduction remains unclear. We aimed to assess the association between the use of VKA or DOAC and the incidence of cancer in a large cohort of AF patients by meaans of a population-based, propensity-weighted cohort study using population-wide databases including patients diagnosed with non-valvular AF (NVAF) followed for up of 5 years (median 2.94 years). We created two cohorts based on the initiation therapy (VKA or DOAC). Initiation with VKA or DOAC was defined as filling a prescription with no previous exposure in the preceding 12 months...
July 9, 2021: Clinical Pharmacology and Therapeutics
https://read.qxmd.com/read/33087337/atrial-fibrillation-dashboard-evaluation-using-the-think-aloud-protocol
#6
JOURNAL ARTICLE
Simon de Lusignan, Harshana Liyanage, Julian Sherlock, Filipa Ferreira, Neil Munro, Michael Feher, Richard Hobbs
BACKGROUND: Atrial fibrillation (AF) is a common cardiac arrhythmia which is a major risk factor for stroke, transient ischaemic attacks and increased mortality. Primary care management of AF can significantly reduce these risks. We carried out an evaluation to asses the usability of an AF dashboard developed to improve data quality and the quality of care. METHOD: We developed an online dashboard about the quality of AF management for general practices of the Oxford Royal College of General Practitioners Research and Surveillance Centre network...
October 2020: BMJ health & care informatics
https://read.qxmd.com/read/32579506/a-review-on-the-use-of-reversal-agents-of-direct-oral-anticogulant-drugs-in-case-of-gastrointestinal-bleeding
#7
REVIEW
Veronica Ojetti, Angela Saviano, Mattia Brigida, Luisa Saviano, Alessio Migneco, Francesco Franceschi
BACKGROUND: Major bleeding is a life-threatening condition and a medical emergency with high mortality risk. It is often the complication of anticoagulant's intake. Anticoagulants are commonly used for the prevention and treatment of thrombotic events. The standard therapy with vitamin K antagonist (warfarin) has been frequently replaced by direct oral anticoagulants (DOACs). The latter agents (rivaroxaban, apixaban, edoxaban, dabigatran, and betrixaban) showed better efficacy and safety compared to standard warfarin treatment and they are recommended for the reduction of ischemic stroke...
2020: Reviews on Recent Clinical Trials
https://read.qxmd.com/read/30354610/management-of-intraprocedural-anticoagulation-in-patients-on-non-vitamin-k-antagonist-oral-anticoagulants-undergoing-catheter-ablation-for-atrial-fibrillation
#8
JOURNAL ARTICLE
Anne-Céline Martin, Anne Godier, Kumar Narayanan, David M Smadja, Eloi Marijon
Catheter ablation has gained a prominent role in the management of atrial fibrillation (AF), with recent data providing positive evidence on hard outcomes, including hospitalization and mortality. Ablation, however, exposes the patient to a rather unique situation, combining risks for both major bleeding and thromboembolic events. In this setting, the critical importance of rigorous anticoagulation during the procedure has been underlined, and the latest international guidelines now recommend performing AF catheter ablation with uninterrupted non-vitamin K antagonist oral anticoagulants (NOACs) and concomitant administration of unfractionated heparin adjusted to achieve and maintain a target activated clotting time of ≥300 seconds...
August 7, 2018: Circulation
https://read.qxmd.com/read/27909619/the-role-of-ultra-mini-percutaneous-nephrolithotomy-in-the-treatment-of-kidney-stones
#9
JOURNAL ARTICLE
Abdulkadir Tepeler, İsmail Başıbüyük, Muhammed Tosun, Abdullah Armağan
OBJECTIVE: In our study we aimed to evaluate outcomes of ultra-mini-percutaneous nephrolithotomy (UMP) performed for the treatment of kidney stones. MATERIAL AND METHODS: Between October 2014 and September 2015, a single surgeon performed UMP on a total of 49 consecutive patients with symptomatic kidney stones at our center. Pregnants, anticogulant users, patients with bleeding diathesis pyonephrosis, and partial/complete staghorn stones were excluded from the study...
December 2016: Turkish Journal of Urology
https://read.qxmd.com/read/26246717/purification-and-characterization-of-an-anticoagulant-oligopeptide-from-whitmania-pigra-whitman
#10
JOURNAL ARTICLE
Xiaobei Zheng, Juan Li, Zhengwang Chen, Yimei Liu, Keli Chen
BACKGROUND: Dried Whitmania pigra is used for the treatment of cardiovascular and cerebrovascular diseases in traditional Chinese medicine and hot water and alcohol extracts also have anticogulant activity. However, a lower molecular weight and more stable anticogulant is needed. OBJECTIVE: The objective of the following study is to purify and characterize of an anticoagulant oligopeptide from Hirudo (Whitmania pigra Whitman). MATERIALS AND METHODS: Gel filtration on Sephadex G-50, ion exchange on diethylaminoethyl-cellulose, and semi-prepared high-performance liquid chromatography were used to purify Hirudo...
July 2015: Pharmacognosy Magazine
https://read.qxmd.com/read/25773559/critical-appraisal-of-network-meta-analyses-evaluating-the-efficacy-and-safety-of-new-oral-anticoagulants-in-atrial-fibrillation-stroke-prevention-trials
#11
REVIEW
Shannon Cope, Andreas Clemens, Florence Hammès, Herbert Noack, Jeroen P Jansen
OBJECTIVES: To critically appraise published network meta-analyses (NMAs) evaluating the efficacy or safety of the new oral anticogulants (NOACs) dabigatran, rivaroxaban, and apixaban for the prevention of stroke in patients with nonvalvular atrial fibrillation (AF). METHODS: A systematic literature review was performed to identify the relevant NMAs using MEDLINE, EMBASE, Cochrane Library, Database of Abstracts of Reviews of Effects, and Health Technology Assessment...
March 2015: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
https://read.qxmd.com/read/25770008/-oral-anticogulation-for-non-valvular-atrial-fibrilation-in-the-elderly
#12
REVIEW
Fernando Veiga Fernández, María del Rocío Malfeito Jiménez, Sonia María Barros Cerviño, María del Mar Magariños Losada
Anticoagulation in elderly people with non-valvular atrial afibrillation (AF) is a challenge, due to the thromboembolic, as well as the haemorrhagic risks. The correct use of anticoagulants in these patients has shown a higher net clinical benefit when comparing it with a younger population. Non-vitamin K antagonist oral anticoagulants (NOACs) have been compared to oral vitamin K antagonists in several studies that included a sufficient number of elderly people. Favourable results for non-vitamin K antagonist oral anticoagulants were obtained in these studies, making them the preferred treatment for this group of patients...
May 2015: Revista Española de Geriatría y Gerontología
https://read.qxmd.com/read/25511595/-a-systemic-review-of-low-intensity-anticoagulation-therapy-for-chinese-population-with-heart-valve-replacement
#13
REVIEW
Li Dong, Yingkang Shi, Bo Fu, Xiao Teng, Jin Chen, Bengui Zhang
OBJECTIVE: To investigate the safety and efficacy of low intensity anticogulation therapy for chinese population underwent heart valve replacemnt. METHODS: From January 1999 to October 2010, the literatures concering anticoagulation therapy for chinese population with heart valve replacement were researched in following databases: CBM, CNKI, VIP, Pubmed as well as cochrane library. Screening and quality evaluation was conducted according to the inclusion and exclusion criteria...
September 16, 2014: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://read.qxmd.com/read/25268607/effects-of-anticoagulant-therapy-on-pregnancy-outcomes-in-patients-with-thrombophilia-and-previous-poor-obstetric-history
#14
COMPARATIVE STUDY
Ilknur Mutlu, Mehmet Firat Mutlu, Aydan Biri, Berk Bulut, Mehmet Erdem, Ahmet Erdem
This study investigates the effects of anticoagulant therapy on pregnancy outcomes in 204 patients with thrombophilia and previous poor obstetric outcomes. Patients with poor obstetric history (pre-eclampsia, intrauterine growth retardation, fetal death, placental abruption, recurrent pregnancy loss) and having hereditary thrombophilia were included in this study. Poor obstetric outcomes were observed more frequently in patients who had not taken anticogulant therapy compared with treated group. Live birth rate, gestational age at birth and Apgar scores were significantly higher in the treated group when compared with the untreated group...
April 2015: Blood Coagulation & Fibrinolysis: An International Journal in Haemostasis and Thrombosis
https://read.qxmd.com/read/25016696/is-automated-kinetic-measurement-superior-to-end-point-for-advanced-oxidation-protein-product
#15
JOURNAL ARTICLE
Osman Oguz, Berrin Bercik Inal, Turker Emre, Oguzhan Ozcan, Esma Altunoglu, Gokce Oguz, Cigdem Topkaya, Guvenc Guvenen
BACKGROUND: Advanced oxidation protein product (AOPP) was first described as an oxidative protein marker in chronic uremic patients and measured with a semi-automatic end-point method. Subsequently, the kinetic method was introduced for AOPP assay. We aimed to compare these two methods by adapting them to a chemistry analyzer and to investigate the correlation between AOPP and fibrinogen, the key molecule responsible for human plasma AOPP reactivity, microalbumin, and HbA1c in patients with type II diabetes mellitus (DM II)...
2014: Clinical Laboratory
https://read.qxmd.com/read/24888786/-computer-aided-dosage-management-of-phenprocoumon-anticoagulation-therapy-clinical-validation
#16
JOURNAL ARTICLE
R Dissmann, L J Cromme, A Salzwedel, U Taborski, J Kunath, F Gäbler, K Heyne, H Völler
UNLABELLED: A recently developed multiparameter computer-aided expert system (TheMa) for guiding anticoagulation with phenprocoumon (PPC) was validated by a prospective investigation in 22 patients. The PPC-INR-response curve resulting from physician guided dosage was compared to INR values calculated by "twin calculation" from TheMa recommended dosage. Additionally, TheMa was used to predict the optimal time to perform surgery or invasive procedures after interruption of anticogulation therapy...
2014: Hämostaseologie
https://read.qxmd.com/read/24868905/-methods-of-preparation-of-the-platelet-rich-plasma-used-in-medicine-as-an-accelerator-of-tissue-regeneration
#17
REVIEW
Lena Kesy, Przemysław Kopczyński, Aleksandra Baszczuk, Zygmunt Kopczyński
Platelet rich plasma is being increasingly used in the modem medicine as a material, stimulating regeneration and accelerating tissue healing. Platelet rich plasma is an autologous platelet concentrate, which is obtained from the peripheral blood of the patient. The method of extraction is based on the isolation of platelets during centrifugation of the whole blood, drew on anticoagulant. With the difference in density between the various cellular components of blood, such as red blood cells, buffy coat and platelet poor plasma, the separation into individual fractions is possible...
April 2014: Polski Merkuriusz Lekarski: Organ Polskiego Towarzystwa Lekarskiego
https://read.qxmd.com/read/24633256/is-female-sex-a-risk-factor-for-stroke-and-thromboembolism-in-patients-with-atrial-fibrillation-a-systematic-review-and-meta-analysis
#18
REVIEW
A J Wagstaff, T F Overvad, G Y H Lip, D A Lane
BACKGROUND: Atrial fibrillation (AF) increases the risk of stroke, but this risk is not homogenous. Many risk factors contribute to stroke risk however, the evidence for female sex as a risk factor is less well-established. AIM: To perform a systematic review and meta-analysis of the available evidence to establish if female sex is a risk factor for stroke/thromboembolism among patients with AF. METHODS: A systematic literature search was conducted using Medline...
December 2014: QJM: Monthly Journal of the Association of Physicians
https://read.qxmd.com/read/24579463/-the-study-of-the-expression-of-tcr-bv-cdr3-family-in-fulminant-hepatitis-b-patients
#19
JOURNAL ARTICLE
Wen-Juan Shi, Hong Wan, Jian Zhou, Li Wei, Zheng-Mao Yang, Zhao-Xun Wang
OBJECTIVE: To study the expression of TCR BV CDR3 family in fulminant hepatitis B (FHB) patients. METHODS: Totally 28 patients with fulminant hepatitis B (FHB) (FHB group), who were treated in our hospital from Oct. 2010. to Mar. 2012, and 20 healthy controls( HC group) were included in the study. PBMCs were isolated from anticogulated blood, and RT-PCR was used to detect the levels of TCR BV CDR3 family in the 2 groups. RESULTS: The levels of DeltaCt1, DeltaCt12 and DeltaCt20 in FHB group were higher than those in HC group (P < 0...
August 2013: Chinese Journal of Experimental and Clinical Virology
https://read.qxmd.com/read/24484463/antivitamin-k-drugs-in-stroke-prevention
#20
REVIEW
Domenico Di Raimondo, Antonino Tuttolomondo, Carmelo Buttà, Benedetto Lucifora, Giuseppe Licata, Antonio Pinto
Among the different subtypes of ischaemic strokes, almost 20 % are of cardiac origin. Different are the causes of cardioembolic stroke, but the most common is the atrial fibrillation, a supraventricular arrhythmia. Appropriate use of antiplatelet drugs and anticoagulants after transient ischaemic attack (TIA) or ischaemic stroke depends on whether the underlying cause is cardioembolic or of presumed arterial origin. Adequate antiplatelet therapy is recommended for secondary prevention after cerebral ischaemia of presumed arterial origin, whether for patients with TIA and ischaemic stroke of cardiac origin, mainly due to atrial fibrillation...
November 2013: Current Vascular Pharmacology
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