keyword
https://read.qxmd.com/read/38504832/antihistamine-and-wound-healing-potential-of-gold-nanoparticles-synthesized-using-bulbine-frutescens-l-willd
#21
JOURNAL ARTICLE
Marizé Cuyler, Danielle Twilley, Velaphi C Thipe, Vusani Mandiwana, Michel L Kalombo, Suprakas S Ray, Rirhandzu Shamaine Rikhotso-Mbungela, Arno Janse van Vuuren, Will Coetsee, Kattesh V Katti, Namrita Lall
BACKGROUND: Atopic dermatitis (eczema) is an inflammatory skin condition with synthetic treatments that induce adverse effects and are ineffective. One of the proposed causes for the development of the condition is the outside-in hypothesis, which states that eczema is caused by a disruption in the skin barrier. These disruptions include developing dry cracked skin, which promotes the production of histamine. Bulbine frutescens (BF) is traditionally used to treat wounds and eczema; however, limited research has been conducted to scientifically validate this...
2024: Nanotechnology, Science and Applications
https://read.qxmd.com/read/38500882/unraveling-the-skin-a-comprehensive-review-of-atopic-dermatitis-current-understanding-and-approaches
#22
REVIEW
Moeina Afshari, Martina Kolackova, Michaela Rosecka, Jarmila Čelakovská, Jan Krejsek
Atopic dermatitis, also known as atopic eczema, is a chronic inflammatory skin disease characterized by red pruritic skin lesions, xerosis, ichthyosis, and skin pain. Among the social impacts of atopic dermatitis are difficulties and detachment in relationships and social stigmatization. Additionally, atopic dermatitis is known to cause sleep disturbance, anxiety, hyperactivity, and depression. Although the pathological process behind atopic dermatitis is not fully known, it appears to be a combination of epidermal barrier dysfunction and immune dysregulation...
2024: Frontiers in Immunology
https://read.qxmd.com/read/38496894/advancing-cancer-theranostics-through-biomimetics-a-comprehensive-review
#23
REVIEW
Kuttiappan Anitha, Santenna Chenchula, Vijayaraj Surendran, Bhatt Shvetank, Parameswar Ravula, Rhythm Milan, Radhika Chikatipalli, Padmavathi R
Nanotheranostics, especially those employing biomimetic approaches, are of substantial interest for molecular imaging and cancer therapy. The incorporation of diagnostics and therapeutics, known as cancer theranostics, represents a promising strategy in modern oncology. Biomimetics, inspired by nature, offers a multidisciplinary avenue with potential in advancing cancer theranostics. This review comprehensively analyses recent progress in biomimetics-based cancer theranostics, emphasizing its role in overcoming current treatment challenges, with a focus on breast, prostate, and skin cancers...
March 30, 2024: Heliyon
https://read.qxmd.com/read/38493820/carrageenan-xanthan-nanocomposite-film-with-improved-bioadhesion-and-permeation-profile-in-human-skin-a-cutaneous-friendly-platform-for-ketoprofen-local-delivery
#24
JOURNAL ARTICLE
Marcel Henrique Marcondes Sari, Camila Parcianello Saccol, Vanessa Neuenschwander Custódio, Lucas Saldanha da Rosa, Juliê Silveira da Costa, André Ricardo Fajardo, Luana Mota Ferreira, Letícia Cruz
Ketoprofen (KET), commonly used for inflammation in clinical settings, leads to systemic adverse effects with prolonged use, mitigated by topical administration. Nanotechnology-based cutaneous forms, like films, may enhance KET efficacy. Therefore, this study aimed to prepare and characterize films containing KET nanoemulsions (F-NK) regarding mechanical properties, chemical composition and interactions, occlusive potential, bioadhesion, drug permeation in human skin, and safety. The films were prepared using a κ-carrageenan and xanthan gum blend (2 % w/w, ratio 3: 1) plasticized with glycerol through the solvent casting method...
March 15, 2024: International Journal of Biological Macromolecules
https://read.qxmd.com/read/38491859/the-combination-of-membrane-disruption-and-ftsz-targeting-by-a-chemotherapeutic-hydrogel-synergistically-combats-pathogens-infections
#25
JOURNAL ARTICLE
Xianyuan Wei, Jintong Guo, Xiaorui Geng, Bin Xue, Shaohui Huang, Zhen Yuan
The emergence of multidrug-resistant (MDR) bacteria poses a significant challenge to global health. Due to a shortage of antibiotics, alternative therapeutic strategies are urgently needed. Unfortunately, colistin, the last-resort antibiotic, has unavoidable nephrotoxicity and hepatotoxicity, and its single killing mechanism is prone to drug resistance. To address this challenge, we propose a promising combinatorial approach that includes colistin, a membrane-disrupting antimicrobial agent, and chelerythrine (CHE), a FtsZ protein inhibitor...
March 16, 2024: Advanced Healthcare Materials
https://read.qxmd.com/read/38490740/robust-gradient-hydrogel-loaded-nanofiber-fleshy-artificial-skin-via-a-coupled-microfluidic-electrospinning-reactive-coating-strategy
#26
JOURNAL ARTICLE
Qing Li, Rong Chen, Tingting Cui, Yuting Bai, Jie Hu, Jiafei Yu, Gefei Wang, Su Chen
Skin regeneration has attracted tremendous interest due to the important role of skin for human protection and beauty. Thus, methods allowing artificial skin to be carried out in a controllable fashion are potentially important for wound healing, which involves an intersection of materials, medicine, biology and other disciplines. Herein, aiming at a new general methodology for fleshy materials, we designed and fabricated a new hydrogel-loaded hydrophobic-hydrophilic nanofiber fleshy artificial skin. The gradient hydrogel-loaded nanofiber artificial skin integrates both advantages of nanofiber and hydrogel, exhibiting fleshy feature (comparability to real skin in terms of appearance, texture and function), excellent air permeability, compatibility, good mechanical and antibacterial property...
March 15, 2024: Advanced Healthcare Materials
https://read.qxmd.com/read/38488127/zeolitic-imidazolate-framework-90-loaded-with-methylprednisolone-sodium-succinate-effectively-reduces-hypertrophic-scar-in-vivo
#27
JOURNAL ARTICLE
Xiaoxiang Xu, Jun Liu, Zixuan Xiao, Shuang Li, Ya Zhang, Peng Song, Kun Lin, Lei Zhang, Haoquan Zheng, Yuye Zhou, Xiong Chen
Hypertrophic scar (HS) is characterized by an abnormal fibroblast-myofibroblast transformation; non-apoptosis of fibroblasts; and redundant expression of TGF-β1, VEGF, α-SMA, and collagen I/III. An HS affects patients' physical and psychological quality of life, leading to joint dysfunction and skin cancer. However, there is currently no satisfactory drug to treat this disorder. In this study, we constructed methylprednisolone sodium succinate (MPSS) encapsulated ZIF-90 (MPSS@ZIF-90) for the effective treatment of an HS...
March 15, 2024: Nanoscale
https://read.qxmd.com/read/38482948/hybrid-interface-chemistry-enabling-mixed-conducting-via-ultrafast-microwave-polarization-toward-dendrite-free-zn-anodes
#28
JOURNAL ARTICLE
Yakai Chen, Yiyao Cao, Ke Chen, Jiayi Rui, Jingxi Chang, Yan Yan, Huijuan Lin, Yan Lu, Cong Zhao, Jixin Zhu, Kun Rui
Zn metal anodes in aqueous electrolytes suffer from interface issues including uncontrolled dendrite growth and undesired side reactions, resulting in their limited application in terms of short circuits and cell failure. Herein, a hybrid interface chemistry strategy is developed through ultrafast microwave polarization at the skin region of bare Zn. Owing to efficient Joule heating directed by abundant local hot spots at electron valleys, the rapid establishment of a dense interfacial layer can be realized within a minute...
March 14, 2024: Small
https://read.qxmd.com/read/38481054/scalable-and-versatile-metal-ion-solidificated-alginate-hydrogel-for-skin-wound-infection-therapy
#29
JOURNAL ARTICLE
By Haomiao Zhang, Ye Lu, Lei Huang, Ping Liu, Jun Ni, Tianqi Yang, Yihong Li, Yu Zhong, Xinping He, Xinhui Xia, Jiancang Zhou
Bacterial infections in wounds continue to be a major challenge in clinical settings worldwide and represent a significant threat to human health. In this work, we have proposed novel expandable and versatile methods for solidifying sodium alginate (SA) with metal ions (such as Fe3+ , Co2+ , Ni2+ , Cu2+ , and Zn2+ ) to create Metal-Alginate (M-Alg) hydrogel with adjustable morphology, composition, and microstructure. It conforms to the wound site, protects against second infection, reduces inflammation, and promotes the healing of infected wounds...
March 13, 2024: Advanced Healthcare Materials
https://read.qxmd.com/read/38478847/3d-bioprinted-human-skin-model-recapitulating-native-like-tissue-maturation-and-immunocompetence-as-an-advanced-platform-for-skin-sensitization-assessment
#30
JOURNAL ARTICLE
Bibrita Bhar, Eshani Das, Kodieswaran Manikumar, Biman B Mandal
Physiologically-relevant in vitro skin models hold utmost importance for efficacy assessments of pharmaceutical and cosmeceutical formulations, offering valuable alternatives to animal testing. Here, we present an advanced immunocompetent three-dimensional (3D) bioprinted human skin model to assess skin sensitization. Initially, a photopolymerizable bioink is formulated using silk fibroin methacrylate, gelatin methacrylate, and photoactivated human platelet releasate. The developed bioink shows desirable physicochemical and rheological attributes for microextrusion bioprinting...
March 13, 2024: Advanced Healthcare Materials
https://read.qxmd.com/read/38477350/novel-smartreservoirs-for-hydrogel-forming-microneedles-to-improve-the-transdermal-delivery-of-rifampicin
#31
JOURNAL ARTICLE
Abraham M Abraham, Qonita Kurnia Anjani, Masoud Adhami, Aaron R J Hutton, Eneko Larrañeta, Ryan F Donnelly
Hydrogel-forming microneedles (HF-MNs) are composed of unique cross-linked polymers that are devoid of the active pharmaceutical ingredient (API) within the microneedle array. Instead, the API is housed in a reservoir affixed on the top of the baseplate of the HF-MNs. To date, various types of drug-reservoirs and multiple solubility-enhancing approaches have been employed to deliver hydrophobic molecules combined with HF-MNs. These strategies are not without drawbacks, as they require multiple manufacturing steps, from solubility enhancement to reservoir production...
March 13, 2024: Journal of Materials Chemistry. B, Materials for Biology and Medicine
https://read.qxmd.com/read/38470769/electronic-skin-based-on-polydopamine-modified-superelastic-fibers-with-superior-conductivity-and-durability
#32
JOURNAL ARTICLE
Chengfeng Chen, Yimiao Wang, Hang Wang, Xinqing Wang, Mingwei Tian
Owing to their excellent elasticities and adaptability as sensing materials, ionic hydrogels exhibit significant promise in the field of intelligent wearable devices. Nonetheless, molecular chains within the polymer network of hydrogels are susceptible to damage, leading to crack extension. Hence, we drew inspiration from the composite structure of the human dermis to engineer a composite hydrogel, incorporating dopamine-modified elastic fibers as a reinforcement. This approach mitigates crack expansion and augments sensor sensitivity by fostering intermolecular forces between the dopamine on the fibers, the hydrogel backbone, and water molecules...
February 28, 2024: Nanomaterials
https://read.qxmd.com/read/38470207/polyphosphate-nanoparticles-balancing-energy-requirements-in-tissue-regeneration-processes
#33
REVIEW
Werner E G Müller, Meik Neufurth, Shunfeng Wang, Heinz C Schröder, Xiaohong Wang
Nanoparticles of a particular, evolutionarily old inorganic polymer found across the biological kingdoms have attracted increasing interest in recent years not only because of their crucial role in metabolism but also their potential medical applicability: it is inorganic polyphosphate (polyP). This ubiquitous linear polymer is composed of 10-1000 phosphate residues linked by high-energy anhydride bonds. PolyP causes induction of gene activity, provides phosphate for bone mineralization, and serves as an energy supplier through enzymatic cleavage of its acid anhydride bonds and subsequent ATP formation...
March 12, 2024: Small
https://read.qxmd.com/read/38468689/amnion-derived-hydrogels-as-a-versatile-platform-for-regenerative-therapy-from-lab-to-market
#34
REVIEW
Golara Kafili, Hassan Niknejad, Elnaz Tamjid, Abdolreza Simchi
In recent years, the amnion (AM) has emerged as a versatile tool for stimulating tissue regeneration and has been of immense interest for clinical applications. AM is an abundant and cost-effective tissue source that does not face strict ethical issues for biomedical applications. The outstanding biological attributes of AM, including side-dependent angiogenesis, low immunogenicity, anti-inflammatory, anti-fibrotic, and antibacterial properties facilitate its usage for tissue engineering and regenerative medicine...
2024: Frontiers in Bioengineering and Biotechnology
https://read.qxmd.com/read/38468531/unraveling-skin-carcinoma-a-comprehensive-examination-of-diagnosis-treatment-strategies-and-emerging-therapeutic-avenues-in-skin-cancer-management
#35
JOURNAL ARTICLE
Namrata Bhadouria, Aftab Alam, Awaneet Kaur
Cancer that begins in the skin is by far the most common kind of skin cancer found everywhere in the globe. It is further subdivided into groups, such as basal cell carcinoma and cutaneous squamous cell carcinoma, in addition to other, less common types of skin cancer. In this article, the diagnostic aspects that need to be taken into consideration when utilizing these new guidelines, go over the essential features of cutaneous SCC, conduct an analysis of recent changes in the category of cutaneous SCC, and speak about recent advancements in the categorization of cutaneous SCC...
March 8, 2024: Pharmaceutical Nanotechnology
https://read.qxmd.com/read/38462597/ce6-modified-fe-ions-doped-carbon-dots-as-multifunctional-nanoplatform-for-ferroptosis-and-photodynamic-synergistic-therapy-of-melanoma
#36
JOURNAL ARTICLE
Haiqiu Li, Yichen Dou, Hang Yang, Hanlin Xing, Cheng Zhu, Tao Wang, Zhaopeng Xuan, Mingxi Yang
BACKGROUND: Despite the higher sensitivity of melanoma towards ferroptosis and photodynamic therapy (PDT), the lack of efficient ferroptosis inducers and the poor solubility of photosensitizers restrict their synergistic strategies. With unique advantages, carbon dots (CDs) are expected to serve as innovative building blocks for combination therapy of cancers. RESULTS: Herein, an ferroptosis/PDT integrated nanoplatform for melanoma therapy is constructed based on chlorin e6-modified Fe ions-doped carbon dots (Fe-CDs@Ce6)...
March 10, 2024: Journal of Nanobiotechnology
https://read.qxmd.com/read/38461551/facile-and-cost-effective-fabrication-of-wearable-alpha-naphtholphthalein-based-halochromic-sensor-for-wound-ph-monitoring
#37
JOURNAL ARTICLE
Hee Sung Seo, Hyejin Lim, Taekyung Lim, Keumyoung Seo, Jonguk Yang, Youngsoo Kang, Shin Ji Han, Sanghyun Ju, Sang-Mi Jeong
The sensor, designed to be worn directly on the skin, is suitable for real-time monitoring of the recovery level of not only general wounds, but also difficult-to-heal wounds, such as those with chronic inflammation. Notably, healthy skin has a pH range of 4-6. When a wound occurs, the pH is known to be approximately 7.4. In this study, alpha-naphtholphthalein (Naph) was immersed in a cotton-blended textile to produce a wearable halochromic sensor that clearly changed color depending on the pH of the skin in the range 6-9, including pH 7...
March 10, 2024: Nanotechnology
https://read.qxmd.com/read/38458595/applications-of-nitric-oxide-releasing-nanomaterials-in-dermatology-skin-infections-and-wound-healing
#38
JOURNAL ARTICLE
Sara Abdel Azim, Cleo Whiting, Adam J Friedman
Nitric oxide (NO) is produced in most cells in the skin and is an important regulator of essential cutaneous functions, including responses to UV irradiation, microbial defense, wound healing, melanogenesis and epidermal permeability barrier homeostasis. Harnessing the physiological activities of NO for therapeutic use is difficult because the molecule is highly reactive and unstable. A variety of exogenous NO delivery platforms have been developed and evaluated; however, they have limited clinical applications in dermatology due to instability and poor cutaneous penetration...
March 6, 2024: Nitric Oxide: Biology and Chemistry
https://read.qxmd.com/read/38456378/thermal-responsive-gel-based-overheat-limiter-enabled-intelligent-photothermal-therapy
#39
JOURNAL ARTICLE
Yanji Chu, Qianci Wang, Shanzhi Lyu, Bin Yuan, Jiahao Huang, Ji Li, Yapei Wang
Uncontrolled and excessive photothermal heating in photothermal therapy (PTT) inevitably causes thermal damage to surrounding normal tissues, severely limiting the universality and safety of PTT. To address this issue, an intelligent cooling thermal-responsive (ICTR) gel containing poly(N-isopropylacrylamide-co-acrylamide) (P(NIPAM-AM))microgel is applied onto the skin to realize intelligent PTT, which can avoid excessive heating and accidental injury. The high near-infrared (NIR) light transmittance (> 95%) of the ICTR gel ensures effective light delivery at low temperatures, while the refractive index of the P(NIPAM-AM) microgel increases remarkably when the temperature exceeds a predetermined threshold, resulting in progressively enhanced light scattering and weakened photothermal conversion...
March 8, 2024: Small
https://read.qxmd.com/read/38453672/mofs-and-mof-based-composites-as-next-generation-materials-for-wound-healing-and-dressings
#40
REVIEW
Ashkan Bigham, Negar Islami, Arezoo Khosravi, Atefeh Zarepour, Siavash Iravani, Ali Zarrabi
In recent years, there has been growing interest in developing innovative materials and therapeutic strategies to enhance wound healing outcomes, especially for chronic wounds and antimicrobial resistance. Metal-organic frameworks (MOFs) represent a promising class of materials for next-generation wound healing and dressings. Their high surface area, pore structures, stimuli-responsiveness, antibacterial properties, biocompatibility, and potential for combination therapies make them suitable for complex wound care challenges...
March 7, 2024: Small
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