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https://www.readbyqxmd.com/read/30526035/green-synthesis-and-biological-activity-of-silver-curcumin-nanoconjugates
#1
Ahmed M Abdellah, Mahmoud A Sliem, Mona Bakr, Rehab M Amin
AIM: There is an urgent need to develop alternative antimicrobial agents and, one of which is via the use of nanotechnology. Green synthetic routes are recently being replaced for nanoparticles preparation. Methods results: Silver-curcumin nanoconjugates (Ag-CurNCs) were prepared in an eco-friendly method. The prepared nanomaterials were characterized and the photostability was studied under the influence of UV irradiation. Results showed that, the conjugation between curcumin and silver in the nanoform improve the photostability of curcumin...
November 2018: Future Medicinal Chemistry
https://www.readbyqxmd.com/read/30513731/dealing-with-skin-and-blood-brain-barriers-the-unconventional-challenges-of-mesoporous-silica-nanoparticles
#2
REVIEW
Alessandra Nigro, Michele Pellegrino, Marianna Greco, Alessandra Comandè, Diego Sisci, Luigi Pasqua, Antonella Leggio, Catia Morelli
Advances in nanotechnology for drug delivery are fostering significant progress in medicine and diagnostics. The multidisciplinary nature of the nanotechnology field encouraged the development of innovative strategies and materials to treat a wide range of diseases in a highly specific way, which allows reducing the drug dosage and, consequently, improving the patient's compliance. Due to their good biocompatibility, easy synthesis, and high versatility, inorganic frameworks represent a valid tool to achieve this aim...
December 1, 2018: Pharmaceutics
https://www.readbyqxmd.com/read/30488798/topical-nano-emulgel-for-skin-disorders-formulation-approach-and-characterization
#3
Javed Ahmad, Anuj Gautam, Shahadali Komath, Mehdiya Bano, Anuj Garg, Keerti Jain
BACKGROUNDS: Acne vulgaris is a common chronic skin disease that affects approximately 650 million people or about 9.4% of the population globally. Growing research in the area of nanotechnology over the years has now been exploited in management of various human disorders by their application in drug delivery. These approaches have an enormous opportunity for the designing of a novel, low-dose and effective treatment systems to control acne disease. Topical nanoemulsion-based gel preparations are said to have various benefits over the conventional formulations...
November 28, 2018: Recent Patents on Anti-infective Drug Discovery
https://www.readbyqxmd.com/read/30444194/development-of-topical-nanocarriers-for-skin-cancer-treatment-using-quality-by-design-approach
#4
Erzsebet Csanyi, Mónika Bakonyi, Anita Kovács, Mária Budai-Szűcs, Ildikó Csóka, Szilvia Berkó
BACKGROUND: One of the most compelling medical challenges of this century is the treatment of cancer and among them, skin cancer is the most common type. Thus, current treatments need to be renewed continuously to handle this challenge. OBJECTIVE: This review presents considerations which can be employed during the development of nanosized formulations dedicated to the topical treatment of skin cancer. We aimed to collect and organize literature data on the treatment options for skin cancer in order to determine the required quality attributes of an effective dermal anticancer formulation...
November 16, 2018: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/30368765/advances-in-carbon-nanotubes-for-malignant-melanoma-a-chance-for-treatment
#5
REVIEW
Elidamar Nunes de Carvalho Lima, José Roberto Castilho Piqueira, Durvanei Augusto Maria
Malignant melanoma is an aggressive skin cancer with limited therapeutic options. Cancer is the second largest cause of death in society and one of the most difficult diseases to treat. Advances in biotechnology have enabled the current use of nanotechnology via the application of nanomaterials, especially as drug delivery systems for the transportation of very small particles. In this context, carbon nanotubes, with a potential role in the diagnosis and treatment of melanoma, are still an emerging research field...
December 2018: Molecular Diagnosis & Therapy
https://www.readbyqxmd.com/read/30359833/use-of-cerium-oxide-nanoparticles-conjugated-with-microrna-146a-to-correct-the-diabetic-wound-healing-impairment
#6
Carlos Zgheib, Sarah A Hilton, Lindel C Dewberry, Maggie M Hodges, Subhadip Ghatak, Junwang Xu, Sushant Singh, Sashwati Roy, Chandan K Sen, Sudipta Seal, Kenneth W Liechty
BACKGROUND: Diabetic wounds have become one of the most challenging public health issues of the 21st century and yet there's no effective treatment available. We have previously shown that the diabetic wound healing impairment is associated with increased inflammation and decreased expression of the regulatory microRNA miR-146a. We have conjugated miR-146a to cerium oxide nanoparticles (CNP-miR146a) to target reactive oxygen species (ROS) and inflammation. This study aims to evaluate the consequences of CNP-miR146a treatment of diabetic wounds...
September 27, 2018: Journal of the American College of Surgeons
https://www.readbyqxmd.com/read/30288248/performing-dna-nanotechnology-operations-on-a-zebrafish
#7
Jian Yang, Zhuojun Meng, Qing Liu, Yasuhito Shimada, René C L Olsthoorn, Herman P Spaink, Andreas Herrmann, Alexander Kros
Nanoscale engineering of surfaces is becoming an indispensable technique to modify membranes and, thus cellular behaviour. Here, such membrane engineering related was explored on the surface of a living animal using DNA nanotechnology. We demonstrate the immobilization of oligonucleotides functionalized with a membrane anchor on 2 day old zebrafish. The protruding single-stranded DNA on the skin of zebrafish served as a handle for complementary DNAs, which allowed the attachment of small molecule cargo, liposomes and dynamic relabeling by DNA hybridization protocols...
September 28, 2018: Chemical Science
https://www.readbyqxmd.com/read/30276135/nanotechnology-in-wound-healing-semisolid-dosage-forms-containing-curcumin-ampicillin-solid-lipid-nanoparticles-in-vitro-ex-vivo-and-in-vivo-characteristics
#8
Solmaz Ghaffari, Faezeh Alihosseini, Seyed Mahdi Rezayat Sorkhabadi, Sepideh Arbabi Bidgoli, Seyyedeh Elaheh Mousavi, Setareh Haghighat, Ahoo Afshar Nasab, Nooshin Kianvash
Purpose: Wound healing is a natural biologic process, but the duration of it may take too long. Trying to shorten this process is one of the challenges for scientists. Many technologies were applied to achieve this goal as well as nanotechnology. In this study semi solid formulations containing curcumin and ampicillin solid lipid nanoparticles (SLNs) were prepared to evaluate as burn wound healing agent. Methods: Curcumin as an anti-inflammatory and anti-bacterial agent and ampicillin as an antibiotic were applied...
August 2018: Advanced Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/30227825/nanotechnological-carriers-for-treatment-of-acne
#9
Shivani Verma, Puneet Utreja, Lalit Kumar
BACKGROUND: Acne is a multifactorial skin disease associated with pilosebaceous unit and caused by bacteria Propionibacterium acnes and Acne vulgaris. Near about 95% people throughout the world suffer from acne at some point in their life span. This disease is more prominent in adults compared to neonates and prepubescent children. Conventionally it is treated with either creams or gels having large number of side effects on patients. METHODS: We searched about recent advancements in the use of nanotechnological carriers for effective treatment of acne...
September 18, 2018: Recent Patents on Anti-infective Drug Discovery
https://www.readbyqxmd.com/read/30214204/natural-product-based-nanomedicines-for-wound-healing-purposes-therapeutic-targets-and-drug-delivery-systems
#10
REVIEW
Marziyeh Hajialyani, Devesh Tewari, Eduardo Sobarzo-Sánchez, Seyed Mohammad Nabavi, Mohammad Hosein Farzaei, Mohammad Abdollahi
Wound healing process is an intricate sequence of well-orchestrated biochemical and cellular phenomena to restore the integrity of the skin and subcutaneous tissue. Several plant extracts and their phytoconstituents are known as a promising alternative for wound healing agents due to the presence of diverse active components, ease of access, and their limited side effects. The development of nanotechnological methods can help to improve the efficacy of different therapeutics as well as herbal-based products...
2018: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/30181504/novel-whole-cell-inactivated-neisseria-gonorrhoeae-microparticles-as-vaccine-formulation-in-microneedle-based-transdermal-immunization
#11
Rikhav P Gala, Rokon Uz Zaman, Martin J D'Souza, Susu M Zughaier
Neisseria gonorrhoeae is a strict human pathogen responsible for more than 100 million new sexually transmitted infections worldwide each year. Due to the global emergence of antibiotic resistance, the Center for Disease control (CDC) recently listed N. gonorrhoeae as an urgent threat to public health. No vaccine is available in spite of the huge disease burden and the possibility of untreatable gonorrhea. The aim of this study is to investigate the immunogenicity of a novel whole-cell-based inactivated gonococcal microparticle vaccine formulation loaded in dissolvable microneedles for transdermal administration...
September 4, 2018: Vaccines
https://www.readbyqxmd.com/read/30122919/evaluation-of-immunoresponses-and-cytotoxicity-from-skin-exposure-to-metallic-nanoparticles
#12
REVIEW
Menglei Wang, Xuan Lai, Longquan Shao, Li Li
Nanotechnology is an interdisciplinary science that has developed rapidly in recent years. Metallic nanoparticles (NPs) are increasingly utilized in dermatology and cosmetology, because of their unique properties. However, skin exposure to NPs raises concerns regarding their transdermal toxicity. The tight junctions of epithelial cells form the skin barrier, which protects the host against external substances. Recent studies have found that NPs can pass through the skin barrier into deeper layers, indicating that skin exposure is a means for NPs to enter the body...
2018: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/30119225/application-of-nanoparticles-in-percutaneous-delivery-of-active-ingredients-in-cosmetic-preparations
#13
REVIEW
Khadijeh Khezri, Majid Saeedi, Solmaz Maleki Dizaj
Developments in nanotechnology have expanded novel nanoparticles for several applications, including cosmetic topical preparation. The aim of this article was to review recent literature on percutaneous delivery of cosmetics active ingredient by nanoparticles. The main focus here, is on lipid based nanoparticles since they are of great importance in skin cargo delivery and have vast application in current cosmetic formulations. Data were collected via electronic databases using MeSH keywords, including nanoparticles, lipid particles, cosmetic, dermal delivery and combinations of these words...
October 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/30094536/melanoma-treatment-from-conventional-to-nanotechnology
#14
REVIEW
Harshita Mishra, Pawan K Mishra, Adam Ekielski, Manu Jaggi, Zeenat Iqbal, Sushama Talegaonkar
INTRODUCTION: Melanoma is the most serious form of skin cancer causing most of the skin cancer-related deaths. The incidence of melanoma has risen so dramatically over past few years that no other solid or blood malignancy comes close to it in terms of increased incidence. The main problem associated with the treatment of melanoma is low response rate to the existing treatment modalities, which in turn is due to the incomplete response by chemotherapeutic agents and inherent resistance of melanoma cells...
December 2018: Journal of Cancer Research and Clinical Oncology
https://www.readbyqxmd.com/read/30094529/biopolymers-applications-in-wound-healing-and-skin-tissue-engineering
#15
REVIEW
T G Sahana, P D Rekha
Wound is a growing healthcare challenge affecting several million worldwide. Lifestyle disorders such as diabetes increases the risk of wound complications. Effective management of wound is often difficult due to the complexity in the healing process. Addition to the conventional wound care practices, the bioactive polymers are gaining increased importance in wound care. Biopolymers are naturally occurring biomolecules synthesized by microbes, plants and animals with highest degree of biocompatibility. The bioactive properties such as antimicrobial, immune-modulatory, cell proliferative and angiogenic of the polymers create a microenvironment favorable for the healing process...
August 9, 2018: Molecular Biology Reports
https://www.readbyqxmd.com/read/30071805/nanotechnology-advances-for-hair-loss
#16
Maira N Pereira, Camila Y Ushirobira, Marcilio Ss Cunha-Filho, Guilherme M Gelfuso, Tais Gratieri
Alopecia is the partial or total reduction of hair in a specific area of the skin that affects millions of men and women worldwide. Most common approved treatments present inconvenient therapeutic regimes and serious adverse effects. In this scenario, nanoencapsulation has emerged as a relatively simple technology for improving the therapeutic outcome of this pathology, promoting a targeted drug delivery with enhanced local bioavailability, which could reduce the adverse effects. Herein, we present some recent studies involving the nanosystems developed for the pharmacological treatment of alopecia, highlighting how each system represents an improvement in relation to conventional drug products and the future perspectives of these new technologies in reaching the market...
August 2018: Therapeutic Delivery
https://www.readbyqxmd.com/read/30051726/microneedle-arrays-for-vaccine-delivery-the-possibilities-challenges-and-use-of-nanoparticles-as-a-combinatorial-approach-for-enhanced-vaccine-immunogenicity
#17
Aoife Maria Rodgers, Ana Sara Cordeiro, Adrien Kissenpfennig, Ryan F Donnelly
Vaccination is one of the greatest breakthroughs of modern preventative medicine. Despite this, there remain problems surrounding delivery, efficacy and compliance. Thus, there is a pressing need to develop cost-effective vaccine delivery systems that could expand the use of vaccines, particularly within developing countries. Microneedle (MN) arrays, given their ease of use, painlessness and ability to target skin antigen presenting cells, provide an attractive platform for improved vaccine delivery and efficacy...
September 2018: Expert Opinion on Drug Delivery
https://www.readbyqxmd.com/read/30005092/nitric-oxide-releasing-nanoparticles-as-a-strategy-to-improve-current-onychomycosis-treatments
#18
Caroline B Costa-Orlandi, Breanne Mordorski, Ludmila M Baltazar, Maria José S Mendes-Giannini, Joel M Friedman, Joshua D Nosanchuk, Adam J Friedman
Topical antimicrobials are the ideal mode of onychomycosis treatment for efficient drug delivery and avoidance of sytemic effects associated with oral medications. However, high treatment costs, tissue penetration limitations, and low cure rates have continued to pose major challenges. To capitalize on the progress made by topical efinaconazole solution, efinaconazole was combined with inexpensive, previously-characterized nitric oxide releasing nanoparticles (NO-np), which have been shown to offer sustained nitric oxide release over time and enhanced barrier penetration, while exerting broad spectrum antimicrobial and immunomodulating properties...
July 1, 2018: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/29920573/graphene-and-graphene-oxide-induce-ros-production-in-human-hacat-skin-keratinocytes-the-role-of-xanthine-oxidase-and-nadh-dehydrogenase
#19
Marco Pelin, Laura Fusco, Cristina Martín, Silvio Sosa, Javier Frontiñán-Rubio, Jose Miguel González-Domínguez, Mario Durán-Prado, Ester Vázquez, Maurizio Prato, Aurelia Tubaro
The extraordinary physicochemical properties of graphene-based nanomaterials (GBNs) make them promising tools in nanotechnology and biomedicine. Considering the skin contact as one of the most feasible exposure routes to GBNs, the mechanism of toxicity of two GBNs (few-layer-graphene, FLG, and graphene oxide, GO) towards human HaCaT skin keratinocytes was investigated. Both materials induced a significant mitochondrial membrane depolarization: 72 h cell exposure to 100 μg mL-1 FLG or GO increased mitochondrial depolarization by 44% and 56%, respectively, while the positive control valinomycin (0...
July 5, 2018: Nanoscale
https://www.readbyqxmd.com/read/29807522/current-state-of-nanomedicines-in-the-treatment-of-topical-infectious-disorders
#20
Kanika Thakur, Gajanand Sharma, Bhupinder Singh, Sanjay Chhibber, Om Prakash Katare
BACKGROUND: Topical infections, involving a number of diseases such as impetigo, eczema, pustular acne, psoriasis and infected seborrheic dermatitis are one among the many challenges to health which stand out for their profound impact on human species. The treatment of topical infections has always been a difficult proposition because of the lack of efficacy of existing anti-infectives, longer period of treatment and yet incomplete recovery. The increasing emergence of antibiotic resistant bacterial strains like Staphylococcus aureus, Methicillin-Resistant Staphylococcus aureus (MRSA) and Pseudomonas aeruginosa undermine the need of development of new delivery systems to enhance the therapeutic efficacy of existing topical anti-infectives...
May 28, 2018: Recent Patents on Anti-infective Drug Discovery
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