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"mental stress induced myocardial ischemia"

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https://www.readbyqxmd.com/read/29996267/-a-clinical-study-of-mental-stress-induced-myocardial-ischemia-in-patients-with-stable-coronary-artery-disease-and-depression-anxiety
#1
L J Zhang, D F He, Y Yang, L H Pu, L Y Xu, Y X Zhou, M Y Liu
Objectives: Exploring the association between depression/anxiety and mental stress-induced myocardial ischemia (MSIMI) in patients with stable coronary artery disease (CAD). Methods: A total of 178 subjects was enrolled according to the inclusion and exclusion criterion with 88 men and 90 women at age of (54±12)years. The subjects were divided into four groups including CAD with depression/anxiety, CAD without depression/anxiety, depression/anxiety without CAD, and control group based on the state of coronary artery, the scores of Patient Health Questionnaire 9-item (PHQ-9) and Generalized Anxiety Disorder 7-item (GAD-7) ...
July 1, 2018: Zhonghua Nei Ke za Zhi [Chinese Journal of Internal Medicine]
https://www.readbyqxmd.com/read/29794945/brain-correlates-of-mental-stress-induced-myocardial-ischemia
#2
J Douglas Bremner, Carolina Campanella, Zehra Khan, Majid Shah, Muhammad Hammadah, Kobina Wilmot, Ibhar Al Mheid, Bruno B Lima, Ernest V Garcia, Jonathon Nye, Laura Ward, Michael H Kutner, Paolo Raggi, Brad D Pearce, Amit J Shah, Arshed A Quyyumi, Viola Vaccarino
OBJECTIVE: Coronary artery disease (CAD) is a major cause of morbidity and mortality, and despite important advances in our understanding of this disorder, the underlying mechanisms remain under investigation. Recently, increased attention has been placed on the role of behavioral factors such as emotional stress on CAD risk. Brain areas involved in memory and the stress response, including medial prefrontal cortex, insula, and parietal cortex, also have outputs to the peripheral cardiovascular system...
July 2018: Psychosomatic Medicine
https://www.readbyqxmd.com/read/29459465/mental-stress-induced-myocardial-ischemia-in-young-patients-with-recent-myocardial-infarction-sex-differences-and-mechanisms
#3
Viola Vaccarino, Samaah Sullivan, Muhammad Hammadah, Kobina Wilmot, Ibhar Al Mheid, Ronnie Ramadan, Lisa Elon, Pratik M Pimple, Ernest V Garcia, Jonathon Nye, Amit J Shah, Ayman Alkhoder, Oleksiy Levantsevych, Hawkins Gay, Malik Obideen, Minxuan Huang, Tené T Lewis, J Douglas Bremner, Arshed A Quyyumi, Paolo Raggi
BACKGROUND: Mental stress-induced myocardial ischemia (MSIMI) is frequent in patients with coronary artery disease and is associated with worse prognosis. Young women with a previous myocardial infarction (MI), a group with unexplained higher mortality than men of comparable age, have shown elevated rates of MSIMI, but the mechanisms are unknown. METHODS: We studied 306 patients (150 women and 156 men) ≤61 years of age who were hospitalized for MI in the previous 8 months and 112 community controls (58 women and 54 men) frequency matched for sex and age to the patients with MI...
February 20, 2018: Circulation
https://www.readbyqxmd.com/read/29269515/sex-differences-in-hemodynamic-and-microvascular-mechanisms-of-myocardial-ischemia-induced-by-mental-stress
#4
Samaah Sullivan, Muhammad Hammadah, Ibhar Al Mheid, Kobina Wilmot, Ronnie Ramadan, Ayman Alkhoder, Nino Isakadze, Amit Shah, Oleksiy Levantsevych, Pratik M Pimple, Michael Kutner, Laura Ward, Ernest V Garcia, Jonathon Nye, Puja K Mehta, Tené T Lewis, J Douglas Bremner, Paolo Raggi, Arshed A Quyyumi, Viola Vaccarino
OBJECTIVE: To investigate sex-specific vascular mechanisms for mental stress-induced myocardial ischemia (MSIMI). APPROACH AND RESULTS: Baseline data from a prospective cohort study of 678 patients with coronary artery disease underwent myocardial perfusion imaging before and during a public speaking stressor. The rate-pressure product response was calculated as the difference between the maximum value during the speech minus the minimum value during rest. Peripheral vasoconstriction by peripheral arterial tonometry was calculated as the ratio of pulse wave amplitude during the speech over the resting baseline; ratios <1 indicate a vasoconstrictive response...
February 2018: Arteriosclerosis, Thrombosis, and Vascular Biology
https://www.readbyqxmd.com/read/29224740/chest-pain-and-mental-stress-induced-myocardial-ischemia-sex-differences
#5
Pratik Pimple, Muhammad Hammadah, Kobina Wilmot, Ronnie Ramadan, Ibhar Al Mheid, Oleksiy Levantsevych, Samaah Sullivan, Ernest V Garcia, Jonathon Nye, Amit J Shah, Laura Ward, Puja Mehta, Paolo Raggi, J Douglas Bremner, Arshed A Quyyumi, Viola Vaccarino
BACKGROUND: Mental stress-induced myocardial ischemia is a frequent phenomenon in patients with coronary artery disease. Women with coronary artery disease tend to have more mental stress-induced myocardial ischemia and more chest pain/anginal symptoms than men, but whether the association between mental stress-induced myocardial ischemia and angina burden differs in women and men is unknown. METHODS: This was a cross-sectional study with experimental manipulation of 950 individuals with stable coronary artery disease...
May 2018: American Journal of Medicine
https://www.readbyqxmd.com/read/28986223/inflammatory-response-to-mental-stress-and-mental-stress-induced-myocardial-ischemia
#6
Muhammad Hammadah, Samaah Sullivan, Brad Pearce, Ibhar Al Mheid, Kobina Wilmot, Ronnie Ramadan, Ayman Samman Tahhan, Wesley T O'Neal, Malik Obideen, Ayman Alkhoder, Naser Abdelhadi, Heval Mohamed Kelli, Mohamad Mazen Ghafeer, Pratik Pimple, Pratik Sandesara, Amit J Shah, Kareem Mohammed Hosny, Laura Ward, Yi-An Ko, Yan V Sun, Lei Weng, Michael Kutner, J Douglas Bremner, David S Sheps, Fabio Esteves, Paolo Raggi, Viola Vaccarino, Arshed A Quyyumi
BACKGROUND: Mental stress-induced myocardial ischemia (MSIMI) is associated with increased risk of adverse cardiovascular outcomes, yet the underlying mechanisms are not well understood. We measured the inflammatory response to acute laboratory mental stress in patients with coronary artery disease (CAD) and its association with MSIMI. We hypothesized that patients with MSIMI would have a higher inflammatory response to mental stress in comparison to those without ischemia. METHODS: Patients with stable CAD underwent 99mTc sestamibi myocardial perfusion imaging during mental stress testing using a public speaking stressor...
February 2018: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/28917493/usefulness-of-myocardial-annular-velocity-change-during-mental-stress-to-predict-cardiovascular-outcome-in-patients-with-coronary-artery-disease-from-the-responses-of-mental-stress-induced-myocardial-ischemia-to-escitalopram-treatment-trial
#7
RANDOMIZED CONTROLLED TRIAL
Fawaz Alenezi, Beverly H Brummett, Stephen H Boyle, Zainab Samad, Michael A Babyak, Nabil Alzaeim, Jennifer Wilson, Minna M D Romano, Julia L Sun, Mads Ersboll, Christopher M O'Connor, Eric J Velazquez, Wei Jiang
Mental stress-induced myocardial ischemia is common and a prognostic factor of adverse cardiovascular outcomes in patients with coronary artery disease (CAD). The present study aimed at examining associations between mental stress-induced myocardial annular velocity (MAV) and cardiovascular outcome in patients with CAD. MAV, specifically, diastolic early (e'), diastolic late (a'), and systolic (s') velocities were obtained at rest and during mental stress testing in 224 patients with clinically stable CAD. Using Cox regression models, age, sex, and baseline-adjusted mental stress-induced MAV measures were examined as predictors of a priori defined composite event term that comprised all-cause mortality and/or nonfatal cardiovascular events, resulting in an unplanned hospitalization (major adverse cardiovascular events [MACE])...
November 1, 2017: American Journal of Cardiology
https://www.readbyqxmd.com/read/28571621/hemodynamic-catecholamine-vasomotor-and-vascular-responses-determinants-of-myocardial-ischemia-during-mental-stress
#8
Muhammad Hammadah, Ayman Alkhoder, Ibhar Al Mheid, Kobina Wilmot, Nino Isakadze, Naser Abdulhadi, Danielle Chou, Malik Obideen, Wesley T O'Neal, Samaah Sullivan, Ayman Samman Tahhan, Heval Mohamed Kelli, Ronnie Ramadan, Pratik Pimple, Pratik Sandesara, Amit J Shah, Laura Ward, Yi-An Ko, Yan Sun, Irina Uphoff, Brad Pearce, Ernest V Garcia, Michael Kutner, J Douglas Bremner, Fabio Esteves, David S Sheps, Paolo Raggi, Viola Vaccarino, Arshed A Quyyumi
AIMS: Mental stress-induced myocardial ischemia (MSIMI) in patients with coronary artery disease (CAD) is associated with adverse cardiovascular outcomes. We aim to assess hemodynamic, neuro-hormonal, endothelial, vasomotor and vascular predictors of MSIMI. METHODS AND RESULTS: We subjected 660 patients with stable CAD to 99mTc sestamibi myocardial perfusion imaging at rest, with mental (speech task) and with conventional (exercise/pharmacological) stress. Endothelium-dependent flow-mediated dilation (FMD), microvascular reactivity [reactive hyperemia index (RHI)] and arterial stiffness [pulse wave velocity (PWV)] were measured at rest and 30-min after mental stress...
September 15, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28330661/association-between-high-sensitivity-cardiac-troponin-levels-and-myocardial-ischemia-during-mental-stress-and-conventional-stress
#9
Muhammad Hammadah, Ibhar Al Mheid, Kobina Wilmot, Ronnie Ramadan, Ayman Alkhoder, Malik Obideen, Naser Abdelhadi, Shuyang Fang, Ijeoma Ibeanu, Pratik Pimple, Heval Mohamed Kelli, Amit J Shah, Brad Pearce, Yan Sun, Ernest V Garcia, Michael Kutner, Qi Long, Laura Ward, J Douglas Bremner, Fabio Esteves, Paolo Raggi, David Sheps, Viola Vaccarino, Arshed A Quyyumi
OBJECTIVES: This study sought to investigate whether patients with mental stress-induced myocardial ischemia will have high resting and post-mental stress high-sensitivity cardiac troponin I (hs-cTnI). BACKGROUND: Hs-cTnI is a marker of myocardial necrosis, and its elevated levels are associated with adverse outcomes. Hs-cTnI levels may increase with exercise in patients with coronary artery disease. Mental stress-induced myocardial ischemia is also linked to adverse outcomes...
April 2018: JACC. Cardiovascular Imaging
https://www.readbyqxmd.com/read/28067532/mental-stress-induced-left-ventricular-dysfunction-and-adverse-outcome-in-ischemic-heart-disease-patients
#10
RANDOMIZED CONTROLLED TRIAL
Julia L Sun, Stephen H Boyle, Zainab Samad, Michael A Babyak, Jennifer L Wilson, Cynthia Kuhn, Richard C Becker, Thomas L Ortel, Redford B Williams, Joseph G Rogers, Christopher M O'Connor, Eric J Velazquez, Wei Jiang
Aims Mental stress-induced myocardial ischemia (MSIMI) occurs in up to 70% of patients with clinically stable ischemic heart disease and is associated with increased risk of adverse prognosis. We aimed to examine the prognostic value of indices of MSIMI and exercise stress-induced myocardial ischemia (ESIMI) in a population of ischemic heart disease patients that was not confined by having a recent positive physical stress test. Methods and results The Responses of Mental Stress Induced Myocardial Ischemia to Escitalopram Treatment (REMIT) study enrolled 310 subjects who underwent mental and exercise stress testing and were followed annually for a median of four years...
April 2017: European Journal of Preventive Cardiology
https://www.readbyqxmd.com/read/28002382/the-mental-stress-ischemia-prognosis-study-objectives-study-design-and-prevalence-of-inducible-ischemia
#11
Muhammad Hammadah, Ibhar Al Mheid, Kobina Wilmot, Ronnie Ramadan, Amit J Shah, Yan Sun, Brad Pearce, Ernest V Garcia, Michael Kutner, J Douglas Bremner, Fabio Esteves, Paolo Raggi, David S Sheps, Viola Vaccarino, Arshed A Quyyumi
OBJECTIVE: Mental stress-induced myocardial ischemia (MSIMI) is a common phenomenon in patients with coronary artery disease (CAD), but contemporary studies of its prognostic significance and its underlying pathophysiology are limited. METHODS: We prospectively enrolled patients with confirmed CAD in the Mental Stress Ischemia Prognosis Study (MIPS) between 2011 and 2014. All patients underwent mental stress testing using a standardized public speaking task, and ischemia was detected by Tc-sestamibi myocardial perfusion imaging...
April 2017: Psychosomatic Medicine
https://www.readbyqxmd.com/read/27607164/mental-stress-induced-myocardial-ischemia-related-to-generalized-anxiety-disorder-in-a-patient-with-acute-coronary-syndrome-and-normal-coronary-arteries
#12
Julio Cesar Tolentino, Juliana J Schmidt, Guilherme J Schmidt, Claudio Tinoco Mesquita, Sergio L Schmidt
Mental stress-induced myocardial ischemia (MSIMI) has been described in patients with acute coronary syndrome (ACS). We reported the case of a patient admitted with ACS and MSIMI related to generalized anxiety disorder (GAD). Myocardial perfusion imaging (MPI) after exercise stress and computed tomography coronary angiography showed normal results. In contrast, MPI with mental stress documented MSIMI. He began to improve 7 days after starting escitalopram and remained without angina at 1-year follow-up. These data suggest the applicability of mental stress radionuclide imaging for the detection of MSIMI in patients with ACS and GAD, even in normal coronary arteries...
November 2016: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/27559072/sex-differences-in-mental-stress-induced-myocardial-ischemia-in-patients-with-coronary-heart-disease
#13
Viola Vaccarino, Kobina Wilmot, Ibhar Al Mheid, Ronnie Ramadan, Pratik Pimple, Amit J Shah, Ernest V Garcia, Jonathon Nye, Laura Ward, Muhammad Hammadah, Michael Kutner, Qi Long, J Douglas Bremner, Fabio Esteves, Paolo Raggi, Arshed A Quyyumi
BACKGROUND: Emerging data suggest that young women with coronary heart disease (CHD) are disproportionally vulnerable to the adverse cardiovascular effects of psychological stress. We hypothesized that younger, but not older, women with stable CHD are more likely than their male peers to develop mental stress-induced myocardial ischemia (MSIMI). METHODS AND RESULTS: We studied 686 patients (191 women) with stable coronary heart disease (CHD). Patients underwent (99m)Tc-sestamibi myocardial perfusion imaging at rest and with both mental (speech task) and conventional (exercise/pharmacological) stress testing...
August 24, 2016: Journal of the American Heart Association
https://www.readbyqxmd.com/read/26895096/the-role-of-the-myocardial-microvasculature-in-mental-stress-induced-myocardial-ischemia
#14
REVIEW
Huan Ma, Lan Guo, Daozheng Huang, Lei Wang, Liheng Guo, Qingshan Geng, Minzhou Zhang
There is increasing evidence that mental stress can manifest as physical diseases. One such condition is mental stress-induced myocardial ischemia (MSIMI); a silent, transient, myocardial ischemic response to stressful conditions. We propose that the cardiac microvasculature may be an important site for the interplay between mental stress and MSIMI. This study is a review of the literature discussing the prevalence and emerging mechanisms underlying MSIMI. We identified several aspects underlying MSIMI, including psychological, genetic, and physiological causes...
April 2016: Clinical Cardiology
https://www.readbyqxmd.com/read/26813547/-chinese-expert-consensus-on-the-diagnosis-and-treatment-of-mental-stress-induced-myocardial-ischemia-in-patients-with-stable-coronary-artery-disease
#15
(no author information available yet)
No abstract text is available yet for this article.
January 2016: Zhonghua Xin Xue Guan Bing za Zhi
https://www.readbyqxmd.com/read/26575295/anxiety-as-a-risk-factor-in-cardiovascular-disease
#16
REVIEW
Christer Allgulander
PURPOSE OF REVIEW: The narrative review covers recent studies of anxiety as a companion in cardiovascular disease. RECENT FINDINGS: Prospective population-based studies and studies of cases with known cardiovascular disease have been conducted, as well as studies of intervention with coronary bypass grafting, heart transplants, and implantable cardioverter-defibrillators, and subsequent rehabilitation programs. Mental stress-induced myocardial ischemia (MSIMI) stands for this emerging research arena...
January 2016: Current Opinion in Psychiatry
https://www.readbyqxmd.com/read/25983674/metabolomics-analysis-reveals-insights-into-biochemical-mechanisms-of-mental-stress-induced-left-ventricular-dysfunction
#17
Stephen H Boyle, Wayne R Matson, Eric J Velazquez, Zainab Samad, Redford B Williams, Swati Sharma, Beena Thomas, Jennifer L Wilson, Christopher O'Connor, Wei Jiang
Mental stress induced left ventricular dysfunction (LVD) has been associated with a greater risk of adverse events in coronary heart disease (CHD) patients independent of conventional risk indicators. The underlying biochemical mechanisms of this cardiovascular condition are poorly understood. Our objective was to use metabolomics technology to identify biochemical changes that co-occur with mental stress-induced LVD in patients with clinically stable CHD. Participants were adult CHD patients who were recruited for mental stress-induced myocardial ischemia screening...
June 1, 2015: Metabolomics: Official Journal of the Metabolomic Society
https://www.readbyqxmd.com/read/25907488/-clinical-intervention-research-on-mental-stress-induced-myocardial-ischemia
#18
RANDOMIZED CONTROLLED TRIAL
Meiyan Liu, Mengchao Liu
OBJECTIVE: To observe the impact of Xinkeshu on top of standard medication on psychological stress-related emotional and biophysiological parameters in patients with mental stress-induced myocardial ischemia (MSIMI). METHODS: A randomized controlled clinical trial was conducted on 40 patients with MSIMI and patients were randomized into treatment group (n = 21) and control group (n = 19) by random number table method. Patients in the treatment group received Xinkeshu (12 capsules/d) on top of standard therapy, and the control group received placebo on top of standard therapy...
February 2015: Zhonghua Xin Xue Guan Bing za Zhi
https://www.readbyqxmd.com/read/25819856/platelet-aggregation-and-mental-stress-induced-myocardial-ischemia-results-from-the-responses-of-myocardial-ischemia-to-escitalopram-treatment-remit-study
#19
RANDOMIZED CONTROLLED TRIAL
Wei Jiang, Stephen H Boyle, Thomas L Ortel, Zainab Samad, Eric J Velazquez, Robert W Harrison, Jennifer Wilson, Cynthia Kuhn, Redford B Williams, Christopher M O'Connor, Richard C Becker
BACKGROUND: Mental stress-induced myocardial ischemia (MSIMI) is common in patients with ischemic heart disease (IHD) and associated with a poorer cardiovascular prognosis. Platelet hyperactivity is an important factor in acute coronary syndrome. This study examined associations between MSIMI and resting and mental stress-induced platelet activity. METHODS: Eligible patients with clinically stable IHD underwent a battery of 3 mental stress tests during the recruitment phase of REMIT study...
April 2015: American Heart Journal
https://www.readbyqxmd.com/read/25727240/angina-and-mental-stress-induced-myocardial-ischemia
#20
Pratik Pimple, Amit J Shah, Cherie Rooks, J Douglas Bremner, Jonathon Nye, Ijeoma Ibeanu, Paolo Raggi, Viola Vaccarino
OBJECTIVE: Mental stress-induced myocardial ischemia is a common phenomenon in patients with coronary artery disease (CAD) and an emerging prognostic factor. Mental stress ischemia is correlated with ambulatory ischemia. However, whether it is related to angina symptoms during daily life has not been examined. METHODS: We assessed angina frequency (past month) in 98 post-myocardial infarction (MI) subjects (age 18-60 years) using the Seattle Angina Questionnaire...
May 2015: Journal of Psychosomatic Research
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