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https://www.readbyqxmd.com/read/30109574/bioactivity-evaluations-of-betulin-identified-from-the-bark-of-betula-platyphylla-var-japonica-for-cancer-therapy
#1
Hae Min So, Hee Jeong Eom, Dahae Lee, Sil Kim, Ki Sung Kang, Il Kyun Lee, Kwan-Hyuck Baek, Jun Yeon Park, Ki Hyun Kim
Identification of bioactive natural products with anticancer activity as well as alleviating effects on chemotherapy-induced side effects has significant implications for cancer treatment. Betula platyphylla var. japonica, commonly known as Asian white birch, has been used in Chinese traditional medicine for a variety of purposes. In this study, the medicinal properties of betulin from B. platyphylla var. japonica useful for cancer management were investigated. LC/MS analysis revealed that betulin is a main chemical component of the EtOH extract of B...
August 14, 2018: Archives of Pharmacal Research
https://www.readbyqxmd.com/read/30108667/myofascial-massage-for-chronic-pain-and-decreased-upper-extremity-mobility-after-breast-cancer-surgery
#2
Jeanne Massingill, Cara Jorgensen, Jacqueline Dolata, Ashwini R Sehgal
Background: Chronic localized pain and decreased upper extremity mobility commonly occur following breast cancer surgery and may persist despite use of pain medication and physical therapy. Purpose: We sought to determine the value of myofascial massage to address these pain and mobility limitations. Setting: The study took place at a clinical massage spa in the U.S. Midwest. The research was overseen by MetroHealth Medical Center's Institutional Review Board and Case Center for Reducing Health Disparities research staff...
August 2018: International Journal of Therapeutic Massage & Bodywork
https://www.readbyqxmd.com/read/30104496/contact-lens-biosensors
#3
REVIEW
Ryan Chang Tseng, Ching-Chuen Chen, Sheng-Min Hsu, Han-Sheng Chuang
Rapid diagnosis and screening of diseases have become increasingly important in predictive and preventive medicine as they improve patient treatment strategies and reduce cost as well as burden on our healthcare system. In this regard, wearable devices are emerging as effective and reliable point-of-care diagnostics that can allow users to monitor their health at home. These wrist-worn, head-mounted, smart-textile, or smart-patches devices can offer valuable information on the conditions of patients as a non-invasive form of monitoring...
August 13, 2018: Sensors
https://www.readbyqxmd.com/read/30104199/microenvironmental-regulation-of-cancer-cell-metabolism-implications-for-experimental-design-and-translational-studies
#4
REVIEW
Alexander Muir, Laura V Danai, Matthew G Vander Heiden
Cancers have an altered metabolism, and there is interest in understanding precisely how oncogenic transformation alters cellular metabolism and how these metabolic alterations can translate into therapeutic opportunities. Researchers are developing increasingly powerful experimental techniques to study cellular metabolism, and these techniques have allowed for the analysis of cancer cell metabolism, both in tumors and in ex vivo cancer models. These analyses show that, while factors intrinsic to cancer cells such as oncogenic mutations, alter cellular metabolism, cell-extrinsic microenvironmental factors also substantially contribute to the metabolic phenotype of cancer cells...
August 7, 2018: Disease Models & Mechanisms
https://www.readbyqxmd.com/read/30103775/recombination-of-a-dual-car-modified-t-lymphocyte-to-accurately-eliminate-pancreatic-malignancy
#5
Erhao Zhang, Peiwei Yang, Jieyi Gu, Heming Wu, Xiaowei Chi, Chen Liu, Ying Wang, Jianpeng Xue, Weiyan Qi, Qingbo Sun, Shengnan Zhang, Jialiang Hu, Hanmei Xu
BACKGROUND: The therapeutic application of T cells endowing with chimeric antigen receptors (CARs) is faced with "on-target, off-tumor" toxicity against solid tumors, particularly in the treatment of the pancreatic cancer. To our best knowledge, the pancreatic cancer cell line AsPC-1 often highly expressed some distinct tumor-associated antigens, such as carcino-embryonic antigen (CEA) and mesothelin (MSLN). Therefore, in this research, we have characterized dual-receptor CAR-modified T cells (dCAR-T) that exert effective and safe cytotoxicity against AsPC-1 cells...
August 13, 2018: Journal of Hematology & Oncology
https://www.readbyqxmd.com/read/30097486/irgd-guided-tumor-penetrating-nanocomplexes-for-therapeutic-sirna-delivery-to-pancreatic-cancer
#6
Justin H Lo, Liangliang Hao, Mandar D Muzumdar, Srivatsan Raghavan, Ester J Kwon, Emilia M Pulver, Felicia Hsu, Andrew J Aguirre, Brian M Wolpin, Charles S Fuchs, William C Hahn, Tyler Jacks, Sangeeta N Bhatia
Pancreatic cancer is one of the leading causes of cancer death, with 5-year survival of 8.5%. The lack of significant progress in improving therapy reflects our inability to overcome the desmoplastic stromal barrier in pancreatic ductal adenocarcinoma (PDAC) as well as a paucity of new approaches targeting its genetic underpinnings. RNA interference holds promise in targeting key mutations driving PDAC; however, a nucleic acid delivery vehicle that homes to PDAC and breaches the stroma does not yet exist. Noting that the cyclic peptide iRGD mediates tumor targeting and penetration through interactions with αvβ3/5 integrins and neuropilin-1, we hypothesized that "tandem" peptides combining a cell-penetrating peptide and iRGD can encapsulate siRNA to form tumor-penetrating nanocomplexes (TPNs) capable of delivering siRNA to PDAC...
August 10, 2018: Molecular Cancer Therapeutics
https://www.readbyqxmd.com/read/30096563/folate-conjugated-nanobubbles-selectively-target-and-kill-cancer-cells-via-ultrasound-triggered-intracellular-explosion
#7
Shuxin Shen, Ying Li, Yunbin Xiao, Zonglei Zhao, Chuanxi Zhang, Junfen Wang, Hairui Li, Feng Liu, Nvqin He, Ye Yuan, Yongkang Lu, Shengcun Guo, Yan Wang, Wangjun Liao, Yulin Liao, Yanmei Chen, Jianping Bin
With the rapid development of cancer-targeted nanotechnology, a variety of nanoparticle-based drug delivery systems have clinically been employed in cancer therapy. However, multidrug resistance significantly impacts the therapeutic efficacy. Physical non-drug therapy has emerged as a new and promising strategy. This study aimed to determine whether novel folate-nanobubbles (F-NBs), combined with therapeutic ultrasound (US), could act as a safe and effective physical targeted cancer therapy. Using folate-conjugated N-palmitoyl chitosan (F-PLCS), we developed novel F-NBs and characterised their physicochemical properties, internalization mechanism, targeting ability, therapeutic effects, and killing mechanism...
July 30, 2018: Biomaterials
https://www.readbyqxmd.com/read/30096477/formulation-and-in-vitro-evaluation-of-magnetoliposomes-as-a-potential-nanotool-in-colorectal-cancer-therapy
#8
Cristina Lorente, Laura Cabeza, Beatriz Clares, Raúl Ortiz, Lyda Halbaut, Ángel V Delgado, Gloria Perazzoli, José Prados, José L Arias, Consolación Melguizo
Magnetoliposomes (MLPs) offer many new possibilities in cancer therapy and diagnosis, including the transport of antitumor drugs, hyperthermia treatment, detection using imaging techniques, and even cell migration. However, high biocompatibility and functionality after cell internalization are essential to their successful application. We synthesized maghemite nanoparticles (γ-Fe2 O3 ) by oxidizing magnetite cores (Fe3 O4 ) and coating them with phosphatidylcholine (PC) liposomes, obtained using the thin film hydration method, to generate MLPs...
July 31, 2018: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/30094728/physical-activity-and-associations-with-treatment-induced-adverse-effects-among-prostate-cancer-patients
#9
Synne-Kristin Hoffart Bøhn, Sophie Dorothea Fosså, Torbjørn Wisløff, Lene Thorsen
PURPOSE: The present study aimed to determine the level of physical activity (PA) among prostate cancer (PCa) patients across treatment modalities and explore the association between PA and treatment-induced adverse effects (AEs). METHODS: The present study was based on a cross-sectional postal survey among members of the Norwegian Prostate Cancer Association. Patients were eligible for the present study if they had either (1) completed radical prostatectomy, (2) completed radiotherapy and (neo)-adjuvant androgen deprivation therapy (ADT), or (3) were undergoing lifelong ADT...
August 9, 2018: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/30094592/breast-ultrasound-recommendations-for-information-to-women-and-referring-physicians-by-the-european-society-of-breast-imaging
#10
Andrew Evans, Rubina M Trimboli, Alexandra Athanasiou, Corinne Balleyguier, Pascal A Baltzer, Ulrich Bick, Julia Camps Herrero, Paola Clauser, Catherine Colin, Eleanor Cornford, Eva M Fallenberg, Michael H Fuchsjaeger, Fiona J Gilbert, Thomas H Helbich, Karen Kinkel, Sylvia H Heywang-Köbrunner, Christiane K Kuhl, Ritse M Mann, Laura Martincich, Pietro Panizza, Federica Pediconi, Ruud M Pijnappel, Katja Pinker, Sophia Zackrisson, Gabor Forrai, Francesco Sardanelli
This article summarises the information that should be provided to women and referring physicians about breast ultrasound (US). After explaining the physical principles, technical procedure and safety of US, information is given about its ability to make a correct diagnosis, depending on the setting in which it is applied. The following definite indications for breast US in female subjects are proposed: palpable lump; axillary adenopathy; first diagnostic approach for clinical abnormalities under 40 and in pregnant or lactating women; suspicious abnormalities at mammography or magnetic resonance imaging (MRI); suspicious nipple discharge; recent nipple inversion; skin retraction; breast inflammation; abnormalities in the area of the surgical scar after breast conserving surgery or mastectomy; abnormalities in the presence of breast implants; screening high-risk women, especially when MRI is not performed; loco-regional staging of a known breast cancer, when MRI is not performed; guidance for percutaneous interventions (needle biopsy, pre-surgical localisation, fluid collection drainage); monitoring patients with breast cancer receiving neo-adjuvant therapy, when MRI is not performed...
August 9, 2018: Insights Into Imaging
https://www.readbyqxmd.com/read/30094114/gastrointestinal-bleed-from-erosive-gastritis-and-duodenitis-a-sentinel-event-of-invasive-lobular-carcinoma-of-the-breast-and-a-diagnostic-dilemma
#11
Mark Bilinyi Ulanja, Mohamed Taha, Arshad Al-Mashhadani, Bryce D Beutler, Marwah Al-Tekreeti, Christie Elliot, Santhosh Ambika
Metastasis from breast cancer to the gastrointestinal (GI) tract is uncommon, and such events presenting as GI bleeding are exceedingly rare. In some individuals, the absence of classical findings of primary breast cancer coupled with the non-specific nature of GI symptoms may make early detection and diagnosis challenging. Our patient is a 75-year-old female who presented with symptomatic anemia manifesting as progressive dizziness, weakness, and early satiety that developed eight days after right knee arthroplasty...
June 7, 2018: Curēus
https://www.readbyqxmd.com/read/30093008/in-vivo-monitoring-of-tumor-distribution-of-hyaluronan-polymeric-micelles-labeled-or-loaded-with-near-infrared-fluorescence-dye
#12
Eva Achbergerová, Daniela Šmejkalová, Gloria Huerta-Angeles, Karel Souček, Martina Hermannová, Hana Vágnerová, Robert Vícha, Vladimír Velebný
Development of delivery systems which allow real-time visual inspection of tumors is critical for effective therapy. Near-infrared (NIR) fluorophores have a great potential for such an application. To overcome NIR dyes short blood circulation time and increase tumor accumulation, a NIR dye, cypate, was associated with oleyl hyaluronan, which can self-assemble into polymeric aggregates. The cypate association with oleyl hyaluronan was performed either by a covalent linkage, or physical entrapment. The two systems were compared for tumor targeting and contrast enhancement using BALB/c mice bearing 4T1 breast cancer tumors...
October 15, 2018: Carbohydrate Polymers
https://www.readbyqxmd.com/read/30091372/psychotherapeutic-interventions-for-chronic-pain-evidence-rationale-and-advantages
#13
Muhammad Hassan Majeed, Ali Ahsan Ali, Donna M Sudak
Background Long-term use of opioids to treat chronic pain incurs serious risks for the individual-including misuse, abuse, addiction, overdose and death-as well as creating economic, social, and cultural impacts on society as a whole. Chronic pain and substance use disorders are often co-morbid with other medical problems and at the present time, primary care clinicians serve most of this population. Primary care clinicians would benefit from having alternatives to opioids to employ in treating such patients...
August 9, 2018: International Journal of Psychiatry in Medicine
https://www.readbyqxmd.com/read/30082477/a-visually-apparent-and-quantifiable-ct-imaging-feature-identifies-biophysical-subtypes-of-pancreatic-ductal-adenocarcinoma
#14
Eugene J Koay, Yeonju Lee, Vittorio Cristini, John S Lowengrub, Ya'an Kang, F Anthony San Lucas, Brian P Hobbs, Rong Ye, Dalia Elganainy, Muayad Almahariq, Ahmed M Amer, Shun Yu, Deyali Chatterjee, Huaming Yan, Peter C Park, Mayrim V Rios Perez, Dali Li, Naveen Garg, Kim Reiss, Anil Chauhan, Mohamed M Zaid, Newsha Nikzad, Robert A Wolff, Milind Javle, Gauri R Varadhachary, Rachna T Shroff, Prajnan Das, Jeffrey E Lee, Mauro Ferrari, Anirban Maitra, Cullen M Taniguchi, Michael P Kim, Christopher H Crane, Matthew H G Katz, Huamin Wang, Priya Bhosale, Eric P Tamm, Jason B Fleming
BACKGROUND AND AIMS: Pancreatic ductal adenocarcinoma (PDAC) is a heterogeneous disease with variable presentations and natural histories of disease. We hypothesized that different morphologic characteristics of PDAC tumors on diagnostic computed tomography (CT) scans would reflect their underlying biology. METHODS: We developed a quantitative method to categorize the PDAC morphology on pre-therapy CT scans from multiple datasets of patients with resectable and metastatic disease, and correlated these patterns with clinical/pathologic measurements...
August 6, 2018: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/30080905/studies-on-the-non-invasive-anticancer-remedy-of-the-triple-combination-of-epigallocatechin-gallate-pulsed-electric-field-and-ultrasound
#15
Chih-Hsiung Hsieh, Chueh-Hsuan Lu, Yu-Yi Kuo, Wei-Ting Chen, Chih-Yu Chao
Cancer is one of the most troublesome diseases and a leading cause of death worldwide. Recently, novel treatments have been continuously developed to improve the disadvantages of conventional therapies, such as prodigious expenses, unwanted side effects, and tumor recurrence. Here, we provide the first non-invasive treatment that has combined epigallocatechin gallate (EGCG), the most abundant catechin in green tea, with a low strength pulsed electric field (PEF) and a low energy ultrasound (US). It has been observed that the cell viability of human pancreatic cancer PANC-1 was decreased approximately to 20% of the control after this combination treatment for 72 h...
2018: PloS One
https://www.readbyqxmd.com/read/30071893/effect-of-exercise-and-or-reduced-calorie-dietary-interventions-on-breast-cancer-related-endogenous-sex-hormones-in-healthy-postmenopausal-women
#16
REVIEW
Martijn de Roon, Anne M May, Anne McTiernan, Rob J P M Scholten, Petra H M Peeters, Christine M Friedenreich, Evelyn M Monninkhof
BACKGROUND: Physical inactivity and being overweight are modifiable lifestyle risk factors that consistently have been associated with a higher risk of postmenopausal breast cancer in observational studies. One biologic hypothesis underlying this relationship may be via endogenous sex hormone levels. It is unclear if changes in dietary intake, physical activity, or both, are most effective in changing these hormone levels. OBJECTIVE: This systematic review and meta-analysis examines the effect of reduced caloric dietary intake and/or increased exercise levels on breast cancer-related endogenous sex hormones...
August 2, 2018: Breast Cancer Research: BCR
https://www.readbyqxmd.com/read/30067919/differential-diagnosis-of-a-pathological-spine-fracture
#17
Priti J Bhatt, Elliot M Greenberg, Brian D Suh
A 71-year-old woman with a 10-month history of atraumatic low back pain was referred to physical therapy after an insidious exacerbation of symptoms. Red flags raised suspicions for spinal compression fracture, necessitating the physical therapist to contact her physician and recommend imaging. Radiographs and magnetic resonance imaging were ordered, the latter of which showed an acute fracture at T10, with lesions at T9 and in the liver suggesting metastasis. Following bone scintigraphy and an ultrasound-guided biopsy of a liver lesion, she was diagnosed with metastatic breast cancer...
July 2018: Journal of Orthopaedic and Sports Physical Therapy
https://www.readbyqxmd.com/read/30067866/social-adjustment-in-adolescent-survivors-of-pediatric-central-nervous-system-tumors-a-report-from-the-childhood-cancer-survivor-study
#18
Fiona Schulte, Tara M Brinkman, Chenghong Li, Taryn Fay-McClymont, Deo Kumar Srivastava, Kirsten K Ness, Rebecca M Howell, Sabine Mueller, Elizabeth Wells, Douglas Strother, Lucie Lafay-Cousin, Wendy Leisenring, Leslie L Robison, Gregory T Armstrong, Kevin R Krull
BACKGROUND: The purpose of this study was to examine the prevalence and predictors of social difficulties in adolescent survivors of central nervous system (CNS) tumors. METHODS: Six hundred sixty-five survivors of CNS tumors (53.8% male and 51.7% treated with cranial radiation therapy [CRT]), who had a current median age of 15.0 years (range, 2.0-17.0 years) and were a median of 12.1 years (range, 8.0-17.7 years) from their diagnosis, were compared with 1376 survivors of solid tumors (50...
August 1, 2018: Cancer
https://www.readbyqxmd.com/read/30067113/lactoferrin-decorated-vs-pegylated-zein-nanospheres-for-combined-aromatase-inhibitor-and-herbal-therapy-of-breast-cancer
#19
Sarah A El-Lakany, Nazik A Elgindy, Maged W Helmy, Marwa M Abu-Serie, Ahmed O Elzoghby
OBJECTIVES: Herein, we propose combined aromatase inhibitor and herbal therapy of breast cancer as a synergistic therapeutic modality. METHODS: Zein nanospheres were prepared by phase separation for co-delivery of exemestane and luteolin. To enhance their tumor-targeting capability, the nanospheres were coated with PEGylated phospholipids and lactoferrin for passive and active targeting, respectively. RESULTS: The developed nanospheres demonstrated a small particle size and controlled drug release...
August 1, 2018: Expert Opinion on Drug Delivery
https://www.readbyqxmd.com/read/30066560/theranostic-mn-porphyrin-metal-organic-frameworks-for-magnetic-resonance-imaging-guided-nitric-oxide-and-photothermal-synergistic-therapy
#20
Hui Zhang, Xue-Tao Tian, Yue Shang, Yu-Hao Li, Xue-Bo Yin
Chemotherapy remains restricted by its toxic adverse effects and resistance to drugs. The treatment of nitric oxide (NO) combined with imaging-guided physical therapy is a promising alternative for clinical application. Herein, we report nanoscale metal organic frameworks (NMOFs) system to integrate magnetic resonance (MR) imaging, spatiotemporally controllable NO delivery, and photothermal therapy (PTT) as a new means of cancer theranostic. As a proof of concept, the NMOFs are prepared with biocompatible Zr4+ ions and Mn-porphyrin as bridging ligand...
August 1, 2018: ACS Applied Materials & Interfaces
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