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Physical therapy cancer

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https://www.readbyqxmd.com/read/30341298/nanodiamond-autophagy-inhibitor-allosterically-improves-the-arsenical-based-therapy-of-solid-tumors
#1
Zhifen Cui, Yu Zhang, Kai Xia, Qinglong Yan, Huating Kong, Jichao Zhang, Xiaolei Zuo, Jiye Shi, Lihua Wang, Ying Zhu, Chunhai Fan
Arsenic trioxide (ATO) is a successful chemotherapeutic drug for blood cancers via selective induction of apoptosis; however its efficacy in solid tumors is limited. Here we repurpose nanodiamonds (NDs) as a safe and potent autophagic inhibitor to allosterically improve the therapeutic efficacy of ATO-based treatment in solid tumors. We find that NDs and ATO are physically separate and functionally target different cellular pathways (autophagy vs. apoptosis); whereas their metabolic coupling in human liver carcinoma cells remarkably enhances programmed cell death...
October 19, 2018: Nature Communications
https://www.readbyqxmd.com/read/30339481/do-compression-sleeves-reduce-the-incidence-of-arm-lymphedema-and-improve-quality-of-life-two-year-results-from-a-prospective-randomized-trial-in-breast-cancer-survivors
#2
Katarzyna Ochalek, Hugo Partsch, Tomasz Gradalski, Zbigniew Szygula
BACKGROUND: In a previous randomized controlled trial it has been demonstrated that arm compression sleeves worn immediately after breast cancer surgery, including axillary lymph node removal in addition to physical therapy are able to reduce the occurrence of early postoperative swelling and of arm lymphedema up to 1 year and to improve quality of life. The aim of the present investigation was to check the further development of the arm swelling in patients using compression sleeves or not, and to compare the quality of life in women treated due to breast cancer 2 years after surgery...
October 19, 2018: Lymphatic Research and Biology
https://www.readbyqxmd.com/read/30339353/magnetic-targeting-tumor-microenvironment-responsive-intelligent-nanocatalysts-for-enhanced-tumor-ablation
#3
Lili Feng, Rui Xie, Chuanqing Wang, Shili Gai, Fei He, Dan Yang, Piaoping Yang, Jun Lin
Therapeutic nanosystems which can be triggered by the distinctive tumor microenvironment possess great selectivity and safety to treat cancers via in situ transformation of nontoxic prodrugs into toxic therapeutic agents. Here, we constructed an intelligent, magnetic targeting and tumor microenvironment responsive nanocatalysts that can acquire oxidation therapy of cancer via specific reaction at tumor site. The magnetic nanoparticle core of iron carbide-glucose oxidase (Fe5C2-GOD) achieved by physical absorption has a high enzyme payload and the manganese dioxide (MnO2) nanoshell as an intelligent "gatekeeper" shields GOD from premature leaking until reaching tumor tissue...
October 19, 2018: ACS Nano
https://www.readbyqxmd.com/read/30339213/identification-of-signs-and-symptoms-of-axillary-web-syndrome-and-breast-seroma-during-a-course-of-physical-therapy-seven-months-post-lumpectomy-a-case-report
#4
Tamar Jacob, Jillian Bracha
Background and Purpose: Axillary web syndrome (AWS) and seroma are common and function-limiting side effects after breast cancer treatments. Studies of AWS and seroma are rare, and there are no guidelines for physical therapy in these cases. Case Description: After left breast lumpectomy due to invasive ductal carcinoma, a 65-year-old female patient underwent intraoperative radiation therapy and whole breast radiation. Seven months later, during treatment for breast swelling, AWS and breast seroma were identified by a physical therapist certified in lymphedema treatment...
October 18, 2018: Physical Therapy
https://www.readbyqxmd.com/read/30338173/p-q-and-n-type-voltage-gated-calcium-channel-binding-antibodies-associated-with-paraneoplastic-chorea-and-mixed-invasive-ductal-and-lobular-carcinoma-of-the-breasts-in-an-elderly-patient
#5
Kevin Chang, Anita Lwanga, Tanjeev Kaur, Cathy Helgason
Paraneoplastic neurologic syndromes are a group of immune-mediated, cancer-associated disorders affecting the nervous system. While these syndromes are not understood fully, they are reportedly caused by an immune response against common antigens expressed by the cancer and nervous system. We describe the course of a patient who suffered paraneoplastic chorea before being diagnosed with breast cancer. A 70-year-old female presented with complaints of "shaking" movements of her head. History, physical exam findings, and preliminary workup ruled out the hereditary, metabolic, and infectious causes of chorea while brain computed tomography (CT) ruled out chorea due to a basal ganglia lesion...
August 4, 2018: Curēus
https://www.readbyqxmd.com/read/30334366/satisfaction-with-pain-management-and-impact-of-pain-on-quality-of-life-in-cancer-patients
#6
Johnson Lin, Ruey-Kuen Hsieh, Jen-Shi Chen, Kuan-Der Lee, Kun-Ming Rau, Yu-Yun Shao, Yung-Chuan Sung, Su-Peng Yeh, Cheng-Shyong Chang, Ta-Chih Liu, Ming-Fang Wu, Ming-Yang Lee, Ming-Sun Yu, Chia-Jui Yen, Pang-Yu Lai, Wen-Li Hwang, Tzeon-Jye Chiou
AIM: To evaluate the prevalence of pain in cancer outpatients in Taiwan and to investigate the impact of pain on quality of life (QoL) and patient satisfaction. Results were compared to those of a similarly designed study conducted in 2008 to identify trends. METHODS: Adult patients with cancer treated as outpatients in hospitals throughout Taiwan were recruited. Pain intensity and the extent to which pain interfered with QoL were self-reported using a modified version of the Brief Pain Inventory...
October 17, 2018: Asia-Pacific Journal of Clinical Oncology
https://www.readbyqxmd.com/read/30334105/physical-activity-and-exercise-during-preoperative-pancreatic-cancer-treatment
#7
Nathan H Parker, An Ngo-Huang, Rebecca E Lee, Daniel P O'Connor, Karen M Basen-Engquist, Maria Q B Petzel, Xuemei Wang, Lianchun Xiao, David R Fogelman, Keri L Schadler, Richard J Simpson, Jason B Fleming, Jeffrey E Lee, Gauri R Varadhachary, Sunil K Sahai, Matthew H G Katz
PURPOSE: Guidelines recommend exercise to cancer survivors, but limited data exists regarding exercise among patients undergoing preoperative cancer treatment. We examined differences in weekly self-reported exercise and accelerometer-measured physical activity among participants in a home-based exercise program administered during preoperative treatment for pancreatic cancer. METHODS: Participants were encouraged to perform at least 60 min/week of moderate-intensity aerobic exercise and at least 60 min/week of full-body strengthening exercises concurrent with chemotherapy, chemoradiation therapy or both sequentially and received resistance equipment, program instruction, and biweekly follow-up calls to encourage adherence...
October 17, 2018: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/30334035/efficient-in-situ-gene-delivery-via-peg-diacrylate-matrices
#8
Paresh Shrimali, Mathew Peter, Archana Singh, Neha Dalal, Suresh Dakave, Shubhada V Chiplunkar, Prakriti Tayalia
For diseases related to genetic disorders or cancer, many cellular therapies rely on the ex vivo modification of cells for attaining a desired therapeutic effect. The efficacy of such therapies involving the genetic modification of cells relies on the extent of gene expression and subsequent persistence of modified cells when infused into the patient's body. In situ gene delivery implies the manipulation of cells in their in vivo niche such that the effectiveness can be improved by minimizing post manipulation effects like cell death, lack of persistence, etc...
October 18, 2018: Biomaterials Science
https://www.readbyqxmd.com/read/30329114/long-term-survivorship-care-after-cancer-treatment-a-new-emphasis-on-the-role-of-rehabilitation-services
#9
Nicole L Stout, Julie K Silver, Catherine M Alfano, Kirsten K Ness, Laura S Gilchrist
In May of 2018, the National Cancer Policy Forum (NCPF) of the National Academies of Sciences, Engineering, and Medicine (formerly the Institute of Medicine) released a report titled:  Long-Term Survivorship Care After Cancer Treatment: Proceedings of Workshop. NCPF published reports have historically played a significant role in driving policy and payment model changes in oncology care, in addition to elevating awareness regarding the needs of individuals with cancer. The current report provides a specific set of recommendations for improving symptom management and rehabilitation that suggest the integration of rehabilitation services at the point of cancer diagnosis and throughout the continuum of cancer care to effectively screen for and manage the anticipated functional morbidity associated with cancer treatment...
October 17, 2018: Physical Therapy
https://www.readbyqxmd.com/read/30328719/cancer-rehabilitation-current-trends-and-practices-within-an-austrian-university-hospital-center%C3%A2
#10
Richard Crevenna, Franz Kainberger, Christoph Wiltschke, Christine Marosi, Michael Wolzt, Fadime Cenik, Mohammad Keilani
BACKGROUND: Cancer rehabilitation has the goal to improve functional status, quality of life, participation, and can improve quality of patient-centered programs and health care efficiencies. In Austria, inpatient cancer rehabilitation is well established but outpatient rehabilitation has not yet established well. METHODS: The present article is describing current rehabilitation in practice and focuses on cancer rehabilitation in Austria, namely bringing together a descriptive account of current trends and practices within an Austrian University Hospital Center (General Hospital of Vienna linked to the Medical University of Vienna) and the Comprehensive Cancer Centre (CCC) Vienna, Austria...
October 17, 2018: Disability and Rehabilitation
https://www.readbyqxmd.com/read/30328379/selective-drug-free-cancer-apoptosis-by-three-dimensional-self-targeting-magnetic-nickel-oxide-nanomatrix
#11
Sivaprasad Chinnakkannu Vijayakumar, Krishnan Venkatakrishnan, Bo Tan
AIM: To develop a drug-free strategy addressing limitations of current cancer therapy. MATERIALS & METHODS: A 3D self-assembled magnetic nickel oxide (NiO) nanomatrix is synthesized using femtosecond pulsed laser to mimic extracellular matrix. RESULTS: The tunable laser pulse-interaction time and repetition rate aided in generating programmable NiO nanomatrix chemistry. The nanomatrix mimicked extracellular matrix in physical configuration and properties presenting favorable cues to cancerous HeLa cell and fibroblast cell adhesion and proliferation without cytotoxicity...
October 17, 2018: Nanomedicine
https://www.readbyqxmd.com/read/30328326/preliminary-findings-on-the-effectiveness-of-meaning-centered-psychotherapy-in-patients-with-pancreatobiliary-cancer
#12
Jin Sun Ryu, Sun Woo Choi, Sung Su Yun, Bon Hoon Koo, In Seok Choi, Seung Jun Kim, Joon Seong Park, Jeong Ho Seok, Dong Sup Yoon
PURPOSE: This study investigated the effectiveness of meaning-centered psychotherapy (MCP), which is known to be a helpful psychotherapeutic intervention in distressing conditions, for patients with pancreatobiliary cancer. MATERIALS AND METHODS: We recruited 37 patients with pancreatobiliary cancer from three university general hospitals and assessed their psychological characteristics. Patients who reported clinically significant emotional distress were recommended to undergo MCP...
November 2018: Yonsei Medical Journal
https://www.readbyqxmd.com/read/30328167/recent-advances-in-carbon-nanomaterials-for-cancer-phototherapy
#13
Bang-Ping Jiang, Bo Zhou, Zhaoxing Lin, Hong Liang, Xing-Can Shen
Carbon nanomaterials have received great attention from the scientific community over the past few decades because of their unique physical and chemical properties. In this minireview, we will summarize the recent progress of various carbon nanomaterials in the field of cancer phototherapy. The structural characteristics of each category and the surface functionalization strategies of these nanomaterials will be briefly introduced before focusing on their therapeutic applications. Recent advances of carbon nanomaterials on photothermal therapy, photodynamic therapy, and combined phototherapies are presented...
October 16, 2018: Chemistry: a European Journal
https://www.readbyqxmd.com/read/30324350/applications-of-nanoparticles-probes-for-prostate-cancer-imaging-and-therapy
#14
Tang Gao, Anyao Bi, Shuiqi Yang, Yi Liu, Xiangqi Kong, Wenbin Zeng
Prostate cancer (PCa) is the most common type of cancer in men with high morbidity and mortality. However, the current treatment with drugs often leads to chemotherapy resistance. It is known that the multi-disciplines research on molecular imaging is very helpful for early diagnosing, staging, restaging and precise treatment of PCa. In the past decades, the tumor-specific targeted drugs were developed for the clinic to treat prostate cancer. Among them, the emerging nanotechnology has brought about many exciting novel diagnosis and treatments systems for PCa...
2018: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/30324083/functionalized-mos-2-nanosheets-as-multi-gene-delivery-vehicles-for-in-vivo-pancreatic-cancer-therapy
#15
Feng Yin, Tommy Anderson, Nishtha Panwar, Kang Zhang, Swee Chuan Tjin, Beng Koon Ng, Ho Sup Yoon, Junle Qu, Ken-Tye Yong
Transition metal dichalcogenides (TMDCs) are categorized as novel two-dimensional (2D) nanomaterials with unique physical and chemical properties, bearing varied applications in medical and materials sciences. However, only a few works report the application of TMDCs for gene therapy in cancer treatment. Here, we engineer a multi-gene delivery system based on functionalized monolayer MoS2 , which can co-deliver HDAC1 and KRAS small interfering RNAs (siRNAs) to Panc-1 cancer cells for combinational cancer therapy...
2018: Nanotheranostics
https://www.readbyqxmd.com/read/30323306/photo-catalytic-killing-of-hela-cancer-cells-using-facile-synthesized-pure-and-ag-loaded-wo-3-nanoparticles
#16
Rasha A AbuMousa, Umair Baig, Mohammed A Gondal, Mohamad S AlSalhi, Fulwah Yahya Alqahtani, Sultan Akhtar, Fadilah Sfouq Aleanizy, Mohamed A Dastageer
Chemotherapy, the most commonly used therapeutic method for cancer, has the inherent constraint of low bioavailability. A number of physical cancer therapeutic treatments like radiation, ultrasound, photo-acoustic/photo thermal, microwave therapies are based on locating the afflicted sites with the help of imaging, but the serious drawbacks of these treatment options are that they damage the neighboring normal tissues and/or induce undesired cancer metastasis. In addition, these methods of treatment are very expensive and not in the reach of a common man especially in the developing countries...
October 15, 2018: Scientific Reports
https://www.readbyqxmd.com/read/30322499/do-complementary-and-integrative-medicine-therapies-reduce-healthcare-utilization-among-oncology-patients-a-systematic-review-of-the-literature-and-recommendations
#17
REVIEW
Rachel Tillery, Meghan E McGrady
PURPOSE: Complementary and integrative medicine (CIM) is frequently used by oncology teams for reducing physical and emotional side-effects related to cancer treatment. In light of the changing healthcare system, evidence is needed regarding the economic implications of these interventions. The purpose of this study was to: (1) systematically examine the literature for links between CIM interventions and healthcare utilization (2) provide recommendations for growing this area of research...
October 2018: European Journal of Oncology Nursing: the Official Journal of European Oncology Nursing Society
https://www.readbyqxmd.com/read/30321080/adverse-cutaneous-effects-of-neratinib
#18
Ramiz N Hamid, Christine S Ahn, William W Huang
Neratinib is a tyrosine kinase inhibitor that was FDA-approved for extended adjuvant treatment in adults with HER-2 positive breast cancer in 2017. Due to the novelty of the drug, there are no current reports in the literature of adverse cutaneous effects associated with neratinib therapy. We present a case of a woman on neratinib for HER-2 positive infiltrating ductal carcinoma of the right breast who presented to the dermatology clinic with changes to the fingernails, acne, and a rash on the face. Physical examination revealed erythema, induration, and some serum crust along the lateral nail folds of the right 4th and left 3rd digits as well as monomorphic acneiform papules and pustules on the face...
October 15, 2018: Journal of Dermatological Treatment
https://www.readbyqxmd.com/read/30319977/immune-checkpoint-inhibitors-for-the-treatment-of-central-nervous-system-cns-metastatic-disease
#19
REVIEW
Suneel D Kamath, Priya U Kumthekar
While the CNS has long been viewed as an immune-privileged environment, a paradigm shift in neuro-immunology has elevated the role of systemic immunotherapy for the treatment of metastatic disease. Increasing knowledge regarding the presence of a CNS lymphatic system and the physical and biochemical alteration of the blood brain barrier (BBB) by the tumor microenvironment suggests immune cell trafficking in and out of the CNS is possible. Emerging clinical data suggest immune checkpoint inhibitors (ICIs) can stimulate T cells peripherally to in turn have anti-tumor effects in the CNS...
2018: Frontiers in Oncology
https://www.readbyqxmd.com/read/30317432/spirituality-and-physical-health-status-a-longitudinal-examination-of-reciprocal-effects-in-breast-cancer-survivors
#20
Neha G Goyal, Edward H Ip, John M Salsman, Nancy E Avis
PURPOSE: This longitudinal study sought to examine the reciprocal relationship between spirituality and physical health status among breast cancer survivors. METHODS: Breast cancer survivors (N = 634) completed baseline assessments (T1) within 8 months of breast cancer diagnosis and 12 (T2) and 18 months (T3) after their baseline assessment. Spirituality was assessed by the Functional Assessment of Chronic Illness Therapy-Spiritual Well-Being (FACIT-Sp) scale which consists of three subscales: meaning, peace, and faith...
October 13, 2018: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
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