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Fibrosis kidney

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https://www.readbyqxmd.com/read/30114247/deubiquitinase-inhibitor-pr-619-reduces-smad4-expression-and-suppresses-renal-fibrosis-in-mice-with-unilateral-ureteral-obstruction
#1
Kotaro Soji, Shigehiro Doi, Ayumu Nakashima, Kensuke Sasaki, Toshiki Doi, Takao Masaki
Deubiquitinating enzymes (DUBs) remove ubiquitin from their substrates and, together with ubiquitin ligases, play an important role in the regulation of protein expression. Although transforming growth factor (TGF)-β1-Smad signaling is a central pathway of renal fibrosis, the role of DUBs in the expression of TGF-β receptors and Smads during the development of renal fibrosis remains unknown. In this study, we investigated whether PR-619, a pan-DUB inhibitor, suppresses fibrosis in mice with unilateral ureteral obstruction (UUO) and TGF-β1-stimulated normal rat kidney (NRK)-49F cells, a rat renal fibroblast cell line...
2018: PloS One
https://www.readbyqxmd.com/read/30113636/successful-heart-lung-kidney-and-domino-heart-transplantation-following-veno-venous-extracorporeal-membrane-oxygenation-support
#2
Yuanjia Zhu, Yasuhiro Shudo, Anson M Lee, Y Joseph Woo
A 60-year-old man with cystic fibrosis, mediastinal shift and end-stage kidney disease underwent a heart-lung-kidney transplantation. His explanted heart was used for a domino heart transplantation. This case showed an excellent outcome, even with high preoperative acuity requiring veno-venous extracorporeal membrane oxygenation and continuous veno-venous haemodialysis.
August 2, 2018: Interactive Cardiovascular and Thoracic Surgery
https://www.readbyqxmd.com/read/30113367/nonalcoholic-fatty-liver-disease-current-concepts-epidemiology-and-management-strategies
#3
Dunya Tomic, William W Kemp, Stuart K Roberts
Nonalcoholic fatty liver disease (NAFLD) is now the most prevalent liver disease in the world. It involves a spectrum of conditions from hepatic steatosis to nonalcoholic steatohepatitis and liver fibrosis, and is a major cause of cirrhosis and hepatocellular carcinoma. It is defined by presence of steatosis in 5% of hepatocytes or more in the absence of other causes of fatty liver. The metabolic syndrome is the major known risk factor for NAFLD. Dietary contributors such as high fructose intake and coffee consumption appear to increase and decrease the risk of disease respectively, but these links are unclear...
August 14, 2018: European Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/30112104/pm2-5-induced-cardiac-hypertrophy-via-creb-gsk3b-sos1-pathway-and-metabolomics-alterations
#4
Kuan-Lun Li, Yen-Chang Lin
The particle matter with diameter less 2.5μm (PM2.5) easier to adsorb toxic substance, and interfere with pulmonary gas exchange. In this study, cardioprotective effects of low molecular weight (LMW) fucoidan in cardiac hypertrophy subjects induced by PM2.5 exposure was conducted by measuring QT interval, Blood pressure, cardiac structure, metabolites and proteins expression in different organs. After PM2.5 exposure, increase in blood pressure, abnormal cardiac function (Prolongation of Action Potential Duration and QT Interval), and structral remodeling (cardiac hypertrophy and fibrosis) were recorded...
July 20, 2018: Oncotarget
https://www.readbyqxmd.com/read/30111809/aristolochic-acid-i-determine-the-phenotype-and-activation-of-macrophages-in-acute-and-chronic-kidney-disease
#5
Mohsen Honarpisheh, Orestes Foresto-Neto, Stefanie Steiger, Franziska Kraft, Paulina Koehler, Ekaterina von Rauchhaupt, Jan Potempa, Karina Adamowicz, Joanna Koziel, Maciej Lech
Acute and chronic kidney injuries are multifactorial traits that involve various risk factors. Experimental animal models are crucial to unravel important aspects of injury and its pathophysiological mechanisms. Translating knowledge obtained from experimental approaches into clinically useful information is difficult; therefore, significant attention needs to be paid to experimental procedures that mimic human disease. Herein, we compared aristolochic acid I (AAI) acute and chronic kidney injury model with unilateral ischemic-reperfusion injury (uIRI), cisplatin (CP)- or folic acid (FA)-induced renal damage...
August 15, 2018: Scientific Reports
https://www.readbyqxmd.com/read/30111497/evaluating-renal-fibrosis-with-r2-histogram-analysis-of-the-whole-cortex-in-a-unilateral-ureteral-obstruction-model
#6
Tingting Zha, Xiaojun Ren, Zhaoyu Xing, Jinggang Zhang, Xiaojuan Tian, Yanan Du, Wei Xing, Jie Chen
RATIONALE AND OBJECTIVES: The aim of this study was to use histogram analysis to assess the correlation between blood oxygen-level dependent magnetic resonance imaging (BOLD-MRI) and renal fibrosis induced by unilateral ureteral obstruction (UUO) in an animal model for a long experimental period. MATERIALS AND METHODS: The rabbits were randomly divided into a control group (n = 6) and a UUO group (n = 30). The rabbits in the UUO group underwent left ureteral obstruction surgery...
August 12, 2018: Academic Radiology
https://www.readbyqxmd.com/read/30110674/uric-acid-as-a-predictor-of-immunoglobulin-a-nephropathy-progression-a-cohort-study-of-1965-cases
#7
Bin Zhu, Dong-Rong Yu, Ji-Cheng Lv, Yi Lin, Qiang Li, Jia-Zhen Yin, Yuan-Yuan Du, Xuan-Li Tang, Li-Chan Mao, Qiu-Fen Li, Yue Sun, Ling Liu, Xian-Fa Li, Dan Fei, Xin-Yi Wei, Cai-Feng Zhu, Xiao-Xia Cheng, Hong-Yu Chen, Yong-Jun Wang
BACKGROUND: The role of serum uric acid (SUA) level in the progression of Immunoglobulin A nephropathy (IgAN) remains controversial. METHODS: In a cohort of 1,965 cases with biopsy-proven IgAN, we examined the associations of SUA concentration with the primary outcome of a composite of all-cause mortality or kidney failure (defined as a reduction of estimated glomerular filtration rate [eGFR] by 40% from baseline, requirements for dialysis and transplantation), or the outcome of kidney failure alone, assessed using Cox and logistic regression models, respectively, with adjustment for confounders...
August 15, 2018: American Journal of Nephrology
https://www.readbyqxmd.com/read/30108638/cardiac-and-renal-fibrosis-and-oxidative-stress-balance-in-lipopolysaccharide-induced-inflammation-in-male-rats
#8
Fereshteh Asgharzadeh, Rahimeh Bargi, Mahmoud Hosseini, Mehdi Farzadnia, Majid Khazaei
BACKGROUND: Subclinical inflammation induced by persistent exposure to lipopolysaccharide (LPS) is found in some clinical conditions such as obesity or diabetes. This study aimed to investigate the effect of recurrent LPS exposure on inflammatory markers, oxidative stress balance and cardiac and renal fibrosis in male rats. METHODS: Male Wistar rats were divided into control and LPS-treated. LPS (10 mg/kg/week) was injected intraperitoneally. After 4 weeks, left ventricles and kidneys were homogenized and stained with hematoxylin and eosin (H&E) and Masson trichrome for histological examination...
March 2018: ARYA Atherosclerosis
https://www.readbyqxmd.com/read/30107860/therapeutic-potential-of-stromal-cells-of-non-renal-or-renal-origin-in-experimental-chronic-kidney-disease
#9
Cinzia Rota, Marina Morigi, Domenico Cerullo, Martino Introna, Ornella Colpani, Daniela Corna, Chiara Capelli, Ton J Rabelink, Danielle G Leuning, Daniela Rottoli, Ariela Benigni, Carlamaria Zoja, Giuseppe Remuzzi
BACKGROUND: Mesenchymal stromal cell (MSC)-based therapy is a promising strategy for preventing the progression of chronic kidney disease (CKD), with the potential to induce tissue regeneration. In search of the best cellular source we compared, in the rat model of adriamycin (ADR) nephropathy, the regenerative potential of human stromal cells of non-renal origin, such as bone marrow (bm) MSCs and umbilical cord (uc) MSCs, with that of newly discovered stromal cells of renal origin, the kidney perivascular cells (kPSCs) known to exhibit tissue-specific properties...
August 14, 2018: Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/30107561/delayed-spironolactone-administration-prevents-the-transition-from-acute-kidney-injury-to-chronic-kidney-disease-through-improving-renal-inflammation
#10
Jonatan Barrera-Chimal, Leslie Rocha, Isabel Amador-Martínez, Rosalba Pérez-Villalva, Rafael González, Cesar Cortés-González, Norma Uribe, Victoria Ramírez, Nathan Berman, Gerardo Gamba, Norma A Bobadilla
Background: Acute kidney injury (AKI) is not as harmless as previously thought since it may lead to chronic kidney disease (CKD). Because most of the time ischemic AKI occurs unexpectedly, it is difficult to prevent its occurrence and there are no specific therapeutic approaches to prevent the AKI to CKD transition. We aimed to determine whether mineralocorticoid receptor blockade (MRB) in the first days after ischemia/reperfusion (IR) can prevent progression to CKD. Methods: Four groups of male Wistar rats were included: sham and three groups of bilateral renal ischemia for 45 min, one without treatment and the other two receiving spironolactone for 5 or 10 days, starting 24 h after IR...
August 9, 2018: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/30107490/the-metabolic-syndrome-does-not-affect-development-of-collateral-circulation-in-the-post-stenotic-swine-kidney
#11
Xin Zhang, Seo Rin Kim, Christopher M Ferguson, Behzad Ebrahimi, Ahmad F Hedayat, Amir Lerman, Lilach O Lerman
Background: The collateral circulation is important in maintenance of blood supply to the ischemic kidney distal to renal artery stenosis (RAS). Obesity-metabolic syndrome (MetS) preserves renal blood flow (RBF) in the stenotic kidney, but whether this is related to an increase of collateral vessel growth is unknown. We hypothesized that MetS increased collateral circulation around the renal artery. Methods: Twenty-one domestic pigs were randomly divided into unilateral RAS fed an atherogenic (high-fat/high-fructose, MetS-RAS) or standard diet, or controls (n=7 each)...
August 9, 2018: American Journal of Hypertension
https://www.readbyqxmd.com/read/30103003/comparative-incidence-and-excess-risk-of-acute-kidney-injury-in-hospitalized-patients-receiving-vancomycin-and-piperacillin-tazobactam-in-combination-or-as-monotherapy
#12
Joseph J Carreno, Tori Smiraglia, Christopher Hunter, Ellis Tobin, Ben Lomaestro
INTRODUCTION: Combination therapy with vancomycin and piperacillin-tazobactam has been associated with increased risk of acute kidney injury (AKI) as compared to monotherapy. This study was conducted to assess the comparative incidence of AKI due to combination therapy in patients receiving vancomycin and piperacillin-tazobactam in combination or as monotherapy. METHODS: Retrospective, matched, cohort study of patients receiving vancomycin and piperacillin-tazobactam in combination or as monotherapy...
August 10, 2018: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/30102719/microrna-regulation-in-blood-cells-of-renal-transplanted-patients-with-interstitial-fibrosis-tubular-atrophy-and-antibody-mediated-rejection
#13
Mareen Matz, Frederik Heinrich, Christine Lorkowski, Kaiyin Wu, Jens Klotsche, Qiang Zhang, Nils Lachmann, Pawel Durek, Klemens Budde, Mir-Farzin Mashreghi
Interstitial fibrosis/tubular atrophy (IFTA) is associated with reduced allograft survival, whereas antibody-mediated rejection (ABMR) is the major cause for renal allograft failure. To identify specific microRNAs and their regulation involved in these processes, total RNA from blood cells of 16 kidney transplanted (KTx) patients with ABMR, stable graft function (SGF) and with T-cell mediated rejection (TCMR) was isolated. MicroRNA expression was determined by high-throughput sequencing. Differentially expressed candidate microRNAs were analyzed with RT-PCR in patients with SGF (n = 53), urinary tract infection (UTI) (n = 17), borderline rejection (BL) (n = 19), TCMR (n = 40), ABMR (n = 22) and IFTA (n = 30)...
2018: PloS One
https://www.readbyqxmd.com/read/30101942/clinical-and-pathological-characteristics-of-elderly-japanese-patients-with-iga-vasculitis-with-nephritis-a-case-series
#14
Hiroyuki Ueda, Yoichi Miyazaki, Nobuo Tsuboi, Keita Hirano, Shinya Yokote, Emi Kobayashi, Makoto Ogura, Tetsuya Kawamura, Munekazu Ryuzaki, Takashi Yokoo
Objective This case series aimed to identify the clinical and pathological characteristics of elderly patients (≥60 years) with biopsy-proven IgA vasculitis with nephritis (IgAVN). Methods The clinical and pathological presentation and treatment outcomes were compared between two groups. Patients Patients with IgAVN who were ≥19 years old at the time of their renal biopsy were divided into elderly (≥60 years) and adult (19-59 years) groups. Results Of the 23 patients in our study, 13 were elderly. In the elderly group, the median age at the diagnosis was 68 years (range, 60-85 years), with a median follow-up period of 15 months (range, 3-80 months)...
August 10, 2018: Internal Medicine
https://www.readbyqxmd.com/read/30101622/3-3-diindolylmethane-ameliorates-renal-fibrosis-through-the-inhibition-of-renal-fibroblast-activation-in-vivo-and-in-vitro
#15
Zun-En Xia, Juan-Li Xi, Lei Shi
3,3'-Diindolylmethane (DIM), a natural acid condensation extracted from cruciferous plants, exhibits anti-fibrotic effects in hepatic and cardiac fibrosis models. The effects of DIM on renal fibrosis, however, are unclear. This study aimed to explore the protective effects of DIM on renal fibrosis. Unilateral ureteral obstruction (UUO) and transforming growth factor (TGF)-β1-stimulated normal rat kidney (NRK)-49F fibroblast cell mouse models were established. The models were then treated with DIM for the assessment of its anti-fibrotic effects and mechanisms...
November 2018: Renal Failure
https://www.readbyqxmd.com/read/30100243/intracellular-lipids-are-an-independent-cause-of-liver-injury-and-chronic-kidney-disease-in-non-alcoholic-fatty-liver-disease-like-context
#16
Laure Monteillet, Monika Gjorgjieva, Marine Silva, Vincent Verzieux, Linda Imikirene, Adeline Duchampt, Hervé Guillou, Gilles Mithieux, Fabienne Rajas
OBJECTIVE: Ectopic lipid accumulation in the liver and kidneys is a hallmark of metabolic diseases leading to non-alcoholic fatty liver disease (NAFLD) and chronic kidney disease (CKD). Moreover, recent data have highlighted a strong correlation between NAFLD and CKD incidences. In this study, we use two mouse models of hepatic steatosis or CKD, each initiated independently of the other upon the suppression of glucose production specifically in the liver or kidneys, to elucidate the mechanisms underlying the development of CKD in the context of NAFLD-like pathology...
August 1, 2018: Molecular Metabolism
https://www.readbyqxmd.com/read/30099700/toll-like-receptor-4-deficiency-alleviates-chronic-intermittent-hypoxia-induced-renal-injury-inflammation-and-fibrosis
#17
Yan Zhang, Xiaoli Su, Fangfang Zou, Tengjuan Xu, Pinhua Pan, Chengping Hu
BACKGROUND: Obstructive sleep apnea (OSA)-associated chronic kidney disease is mainly caused by chronic intermittent hypoxia (CIH) triggered renal damage. This study aims to investigate the role of toll-like receptor-4 (TLR4) in underlying mechanism involved chronic intermittent hypoxia (CIH)-induced renal damage. METHODS: C57BL/6J mice with normal TLR4 (TLR4 WT) or deficient TLR4 (TLR4 KO) were divided into four groups and exposed to normal air (NA) and CIH: TLR4 WT + NA, TLR4 KO + NA, TLR4 WT + CIH, and TLR4 KO + CIH...
August 11, 2018: Sleep & Breathing, Schlaf & Atmung
https://www.readbyqxmd.com/read/30099457/a-pan-nadph-oxidase-inhibitor-ameliorates-kidney-injury-in-type-1-diabetic-rats
#18
Debra Dorotea, Guideock Kwon, Jung Hwa Lee, Erika Saunders, Yun Soo Bae, Sung Hwan Moon, Soo Jin Lee, Dae Ryong Cha, Hunjoo Ha
BACKGROUND: NADPH oxidases (Nox) is a major enzyme system contributing to oxidative stress, which plays an important role in the pathogenesis of diabetic kidney disease (DKD). We have shown an elevation of renal Nox1, Nox2, and Nox4 in diabetic mice. APX-115, a pan-Nox inhibitor, attenuated the progression of DKD in mice. As the standard diabetic mice cannot fully mimic human DKD, the present study was aimed to show the dose-dependent effect and to provide a confirmatory evidence of APX-115 in attenuating DKD in diabetic rats...
August 10, 2018: Pharmacology
https://www.readbyqxmd.com/read/30098377/nlrp3-deficiency-ameliorates-renal-inflammation-and-fibrosis-in-diabetic-mice
#19
Ming Wu, Weixia Han, Shan Song, Yunxia Du, Chao Liu, Nan Chen, Haijiang Wu, Yonghong Shi, Huijun Duan
Diabetic nephropathy (DN) is the leading cause of end-stage renal disease. Activation of the nucleotide binding and oligomerization domain-like receptor family pyrin domain-containing 3 (NLRP3) inflammasome has been reported in diabetic kidney, yet the potential role of NLRP3 inflammasome in DN is not well known. In this study, we explored the role of NLRP3 inflammasome on inflammation and fibrosis in diabetic kidney using NLRP3 knockout mice. Renal expression of NLRP3, caspase-1 p10, interleukin-18 (IL-18) and cleaved IL-1β was increased in diabetic wild-type (WT) mice at 24 weeks...
August 8, 2018: Molecular and Cellular Endocrinology
https://www.readbyqxmd.com/read/30097458/mechanism-of-fibrosis-in-hnf1b-related-autosomal-dominant-tubulointerstitial-kidney-disease
#20
Siu Chiu Chan, Ying Zhang, Annie Shao, Svetlana Avdulov, Jeremy Herrera, Karam Aboudehen, Marco Pontoglio, Peter Igarashi
BACKGROUND: Mutation of HNF1B , the gene encoding transcription factor HNF-1 β , is one cause of autosomal dominant tubulointerstitial kidney disease, a syndrome characterized by tubular cysts, renal fibrosis, and progressive decline in renal function. HNF-1 β has also been implicated in epithelial-mesenchymal transition (EMT) pathways, and sustained EMT is associated with tissue fibrosis. The mechanism whereby mutated HNF1B leads to tubulointerstitial fibrosis is not known. METHODS: To explore the mechanism of fibrosis, we created HNF-1 β -deficient mIMCD3 renal epithelial cells, used RNA-sequencing analysis to reveal differentially expressed genes in wild-type and HNF-1 β -deficient mIMCD3 cells, and performed cell lineage analysis in HNF-1 β mutant mice...
August 10, 2018: Journal of the American Society of Nephrology: JASN
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