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Fibrosis renal

Ming Wu, Weixia Han, Shan Song, Yunxia Du, Chao Liu, Nan Chen, Haijiang Wu, Yonghong Shi, Huijun Duan
Diabetic nephropathy (DN) is the leading cause of end-stage renal disease. Activation of the nucleotide binding and oligomerization domain-like receptor family pyrin domain-containing 3 (NLRP3) inflammasome has been reported in diabetic kidney, yet the potential role of NLRP3 inflammasome in DN is not well known. In this study, we explored the role of NLRP3 inflammasome on inflammation and fibrosis in diabetic kidney using NLRP3 knockout mice. Renal expression of NLRP3, caspase-1 p10, interleukin-18 (IL-18) and cleaved IL-1β was increased in diabetic wild-type (WT) mice at 24 weeks...
August 8, 2018: Molecular and Cellular Endocrinology
Siu Chiu Chan, Ying Zhang, Annie Shao, Svetlana Avdulov, Jeremy Herrera, Karam Aboudehen, Marco Pontoglio, Peter Igarashi
BACKGROUND: Mutation of HNF1B , the gene encoding transcription factor HNF-1 β , is one cause of autosomal dominant tubulointerstitial kidney disease, a syndrome characterized by tubular cysts, renal fibrosis, and progressive decline in renal function. HNF-1 β has also been implicated in epithelial-mesenchymal transition (EMT) pathways, and sustained EMT is associated with tissue fibrosis. The mechanism whereby mutated HNF1B leads to tubulointerstitial fibrosis is not known. METHODS: To explore the mechanism of fibrosis, we created HNF-1 β -deficient mIMCD3 renal epithelial cells, used RNA-sequencing analysis to reveal differentially expressed genes in wild-type and HNF-1 β -deficient mIMCD3 cells, and performed cell lineage analysis in HNF-1 β mutant mice...
August 10, 2018: Journal of the American Society of Nephrology: JASN
Egor Y Plotnikov, Anna A Brezgunova, Irina B Pevzner, Ljubava D Zorova, Vasily N Manskikh, Vasily A Popkov, Denis N Silachev, Dmitry B Zorov
Neonatal sepsis is one of the major causes of mortality and morbidity in newborns, greatly associated with severe acute kidney injury (AKI) and failure. Handling of newborns with kidney damage can be significantly different compared to adults, and it is necessary to consider the individuality of an organism's response to systemic inflammation. In this study, we used lipopolysaccharide (LPS)-mediated acute kidney injury model to study mechanisms of kidney cells damage in neonatal and adult rats. We found LPS-associated oxidative stress was more severe in adults compared to neonates, as judged by levels of carbonylated proteins and products of lipids peroxidation...
August 8, 2018: Antioxidants (Basel, Switzerland)
Ibnouf Sulieman, Ahmed Mahfouz, Einas AlKuwari, Lajos Szabados, Walid Elmoghazy, Ahmed Elaffandi, Hatem Khalaf
INTRODUCTION: Most patients with pancreatic masses pose a diagnostic challenge when a benign lesion is suspected, and often, resection is needed before a benign diagnosis is confirmed. PRESENTATION OF CASE: A 57 years old male patient presented with a pancreatic head mass, obstructive jaundice and submandibular lymph node enlargement. He also had a history of recurrent eye pain and redness, skin lesions, and benign prostatic hypertrophy. MRI showed a pancreatic head mass with double duct sign, aortic thickening, bilateral renal lesions, diffuse lymph node enlargement, and prostatic enlargement...
July 31, 2018: International Journal of Surgery Case Reports
Simina-Ramona Selejan, Dominik Linz, Anna-Maria Tatu, Mathias Hohl, Thimoteus Speer, Sebastian Ewen, Felix Mahfoud, Ingrid Kindermann, Olesja Zamyatkin, Andrey Kazakov, Ulrich Laufs, Michael Böhm
Receptors-for-Advanced-Glycation-End-products (RAGE) activate pro-inflammatory programs mediated by carboxymethyllysine (CML) and high-mobility-group-box1 protein (HMGB1). The soluble isoform sRAGE neutralizes RAGE-ligands preventing cardiovascular complications in conditions associated with increased sympathetic activation like hypertension and diabetes. The effects of sympathetic modulation on RAGE/sRAGE-balance and end-organ damage in metabolic syndrome on top of hypertension remains unknown. We hypothesized that increased sympathoadrenergic activity might lead to an unfavourable RAGE/sRAGE regulation...
August 7, 2018: Journal of Molecular and Cellular Cardiology
Mariana Machado Forti Nastri, Glaucia Vanessa Novak, Adriana Elias Maluf Sallum, Lucia Maria Arruda Campos, Roberto Augusto Plaza Teixeira, Clovis Artur Silva
INTRODUCTION: Immunoglobulin G4-related disease (IgG4-RD) is an condition rarely reported in children. Additionally, IgG4-RD may rarely mimic vasculitis in adults and may infrequently present with uveitis. In our service, 6,198 patients were followed-up and only one (0.0001%) of them had IgG4-RD. To our knowledge, the present IgG4-RD case was the first mimicking childhood polyarteritis nodosa (c-PAN) with recurrent uveitis and kidney tumor. CASE REPORT: We describe herein a 7-year-old boy that presented intermittent fever...
July 18, 2018: Acta Reumatológica Portuguesa
Rong Xue, Yingping Li, Xiaoli Li, Jingang Ma, Caiping An, Zhigang Ma
Kidney fibrosis is usually the final manifestation of a wide variety of renal diseases. Recent years, research reported that lncRNAs played important roles in a variety of human diseases. However, the role and underlying mechanisms of lncRNAs in kidney fibrosis were complicated and largely unclear. In our study, we constructed the cell model of renal fibrosis in HK2 cells using TGF-β1 and found that lncRNA MEG3 was down-regulated in TGF-β1-induced renal fibrosis. We then found that overexpressed MEG3 inhibited the TGF-β1-induced promotion of EMT, cell viability and proliferation...
August 10, 2018: Cell Biology International
Yuxi Wang, Zhi Zhao, Weiqi Yang, Lin Li, Fengming Zhu, Guangchang Pei, Juan Yang, Han Zhu, Huzi Xu, Meng Wang, Qian Yang, Zhizhi Hu, Pengge Wang, Gang Xu, Rui Zeng, Ying Yao
Tamoxifen is used to activate tamoxifen-dependent Cre recombinase (CreER) to generate time- and tissue-specific genetically mutant mice. However, tamoxifen is also an active estrogen analogue that binds with higher affinity to estrogen receptors and exhibits anti-apoptosis, anti-inflammation, and antifibrotic properties. Renal ischemia reperfusion (I/R) injury is characterized by increased apoptosis and inflammation, so optimal utility of tamoxifen-inducible CreER genetic systems in I/R model is important. The purpose of this study was to optimize the tamoxifen dose and evaluate its safety and tolerability in the development of mouse I/R injury...
2018: American Journal of Translational Research
Wanghui Jing, Bahman Jabbari, Nosratola D Vaziri
Chronic kidney disease (CKD) results in various central nervous systems (CNS) disorders including cognitive dysfunction, depression, anxiety, movement disorders, seizures and encephalopathy. Uremic retention products, oxidative stress, inflammation and impaired blood-brain barrier have been implicated as the major mediators of CKD-induced CNS disorders. However, mechanisms of CKD-induced cerebral tissue oxidative stress, inflammation and impaired blood brain barrier have not been fully elucidated and were explored...
2018: American Journal of Translational Research
Wanghui Jing, Ane Nunes, Ted Farzaneh, Mahyar Khazaeli, Wei Ling Lau, Nosratola D Vaziri
Chronic kidney disease (CKD) causes anemia and impairs intestinal iron absorption. However, use of the phosphate binder, ferric citrate (FC), increases body iron stores and hemoglobin levels in CKD patients. By intensifying oxidative stress and inflammation iron overload can accelerate CKD progression. Present study explored the route of absorption and tissue distribution of iron with FC administration and its effect on renal function, histology and inflammatory, oxidative and fibrosis pathways in CKD rats...
August 9, 2018: Journal of Pharmacology and Experimental Therapeutics
Lili Zhou, Shan Zhou, Peng Yang, Yuan Tian, Zhiwei Feng, Xiang-Qun Xie, Youhua Liu
The cannabinoid receptor type 2 (CB2) is a G protein-coupled seven transmembrane receptor that transmits endogenous cannabinoid signaling. The role of CB2 in the pathogenesis of kidney injury and fibrosis remains poorly understood. Here we demonstrate that CB2 was induced, predominantly in kidney tubular epithelium, in various models of kidney disease induced by unilateral ureteral obstruction, adriamycin or ischemia/reperfusion injury. In vitro, forced expression of CB2 or treatment with a CB2 agonist was sufficient to trigger matrix gene expression, whereas knockdown of CB2 by siRNA abolished transforming growth factor-β1-induced signaling and fibrogenic responses in kidney tubular cells...
August 6, 2018: Kidney International
Noha A T Abbas, Amal El Salem, Mohammed M Awad
Chronic kidney disease (CKD) is a global healthcare problem; however until now, there is no effective treatment that can stop its progression. In this study, we aimed to investigate the effect of empagliflozin, a sodium-glucose linked transporter-2 inhibitor (SGLT2 I) in a model of unilateral ureteric obstruction (UUO) in rats, as a model of progressive renal interstitial fibrosis in vivo and the possibility of inclusion of klotho protein. Rats were randomly divided into five groups: group 1: control group, group 2: UUO untreated group, group 3: prophylactic SGLT2 I treatment before UUO, group 4: immediate SGLT2 I treatment after UUO, and group 5: delayed SGLT2 I treatment (this group received distilled water 1 week after UUO then empagliflozin for 2 weeks)...
August 8, 2018: Naunyn-Schmiedeberg's Archives of Pharmacology
Kai Jiang, Tristan A Ponzo, Hui Tang, Prasanna K Mishra, Slobodan I Macura, Lilach O Lerman
The rodent model of folic acid (FA)-induced acute kidney injury (AKI) provides a useful model for studying human AKI, but little is known about longitudinal changes in renal hemodynamics and evolution of renal fibrosis in vivo. In this work, we aimed to longitudinally assess renal structural and functional changes using multi-parametric magnetic resonance imaging (MRI). Ten adult mice were injected with FA, after which multi-parametric MRI was used to measure kidney volume, hypoxia index R2 * , magnetization transfer ratio (MTR), perfusion, T1 , and glomerular filtration rate (GFR) at 2 weeks post-treatment...
August 8, 2018: American Journal of Physiology. Renal Physiology
Sofia Hussain, Naureen Akhtar, Reem Qamar, Naima Khan, Muhammad Naeem
Nephronophthisis is an autosomal recessive cystic kidney disease characterized by tubular interstitial infiltration, periglomerular fibrosis, and cysts, and is the most frequent genetic cause of end-stage renal disease in children. Nephronophthisis is pleiotropic as almost all the causative genes are involved in primary cilium and centrosome function which are found in almost all human cells. Genetic heterogeneity in nephronophthisis makes the molecular and genetic diagnosis somewhat difficult. Homozygous deletions in the nephronophthisis 1 (NPHP1) gene are the major contributor of nephronophthisis cases, while other genes accounts for less than 3% each...
July 2018: Iranian Journal of Kidney Diseases
Shuang Li, Bingbing Qiu, Hong Lu, Yunshi Lai, Jixing Liu, Jiajun Luo, Fengxin Zhu, Zheng Hu, Miaomiao Zhou, Jianwei Tian, Shouyi Yu, Fan Yi, Jing Nie
AIMS: The risk factors promoting acute kidney injury (AKI) to chronic kidney disease (CKD) progression remains largely unknown. The aim of the present study was to investigate whether hyperhomocysteinemia (Hhcy) accelerates the development of renal fibrosis after AKI. RESULTS: Hhcy aggravated ischemia-reperfusion-induced AKI and the subsequent development of renal fibrotic lesions characterized by excessive extracellular matrix deposition. Mechanistically, the RNA binding protein human antigen R (HuR) bound to the 3'-untranslated region (3'-UTR) of heme oxygenase-1 (HO-1) mRNA...
August 7, 2018: Antioxidants & Redox Signaling
Mei Huang, Jin Zhang, Hui Xu, Ting Ding, Damu Tang, Qiongjing Yuan, Lijian Tao, Zunlong Ye
Renal interstitial fibrosis is a common renal injury resulted from a variety of chronic kidney conditions and an array of factors. We report here that Notch3 is a potential contributor. In comparison to 6 healthy individuals, a robust elevation of Notch3 expression was observed in the renal tubular epithelial cells of 18 patients with obstructive nephropathy. In a rat unilateral ureteral obstruction (UUO) model which mimics the human disease, Notch3 upregulation closely followed the course of renal injury, renal fibrosis, TGFβ expression, and alpha-smooth muscle actin (α-SMA) expression, suggesting a role of Notch3 in promoting tubulointerstitial fibrosis...
August 3, 2018: Cellular Signalling
Weiwei Xi, Xuming Zhao, Meijun Wu, Wenjuan Jia, Hua Li
Although microRNA-155 (miR-155) is implicated in the pathogenesis of several fibrotic diseases, information regarding its functional role in renal fibrosis is limited. The current study aims to investigate the effects of miR-155 on renal fibrosis in unilateral ureteral occlusion (UUO) mice. MiR-155 level was significantly increased in renal tissues of UUO mice and TGF-β1-treated HK2 cells. Masson's trichrome staining showed that delivery of adeno-associated virus encoding miR-155 inhibitor led to a decrease in renal fibrosis induced by UUO...
August 6, 2018: Cell Biology International
Guadalupe Tirma González-Mateo, Lucía Pascual-Antón, Pilar Sandoval, Abelardo Aguilera Peralta, Manuel López-Cabrera
Peritoneal dialysis (PD) is a renal replacement therapy consistent on the administration and posterior recovery of a hyperosmotic fluid in the peritoneal cavity to drain water and toxic metabolites that functionally-insufficient kidneys are not able to eliminate. Unfortunately, this procedure deteriorates the peritoneum. Tissue damage triggers the onset of inflammation to heal the injury. If the injury persists and inflammation becomes chronic, it may lead to fibrosis, which is a common occurrence in many diseases...
July 19, 2018: Journal of Visualized Experiments: JoVE
J Q Li, Y Lu, Y L Qiu, J S Wang
Objective: To summarize and review the clinical and genetic features of neonatal sclerosing cholangitis (NSC) caused by DCDC2 variations. Methods: Whole exome sequencing was performed to identify DCDC2 variants in two Chinese siblings with NSC who were diagnosed in Children's Hospital of Fudan University in May 2017. Clinical, laboratory and genetic data of the two cases were summarized. Key words of "DCDC2" "neonatal sclerosing cholangitis" were searched in Chinese databases and PubMed for articles published until April 2018, and all the relevant literature were reviewed...
August 2, 2018: Zhonghua Er Ke za Zhi. Chinese Journal of Pediatrics
Alireza Mafi, Esmat Aghadavod, Naghmeh Mirhosseini, Moein Mobini, Zatollah Asemi
MicroRNAs (miRNAs) have recently become well-known efficacious biomarkers for the diagnosis of diabetic nephropathy (DN). MiRNAs, short noncoding RNAs, are posttranscriptional regulators of gene expression, which regulate several biological cell functions, including insulin production and secretion, as well as insulin resistance in tissues. Today, the focus of the medical world is centered on the role of miRNAs as mediators for different diseases, such as DN and end-stage renal diseases (ESRD). MiRNAs are stable and detectable in human biological fluids, so their detection for early diagnosis of different diseases is highly sensitive and specific...
August 4, 2018: Journal of Cellular Physiology
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