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https://www.readbyqxmd.com/read/30546893/trabectedin-in-combination-with-pegylated-liposomal-doxorubicin-in-patients-with-ovarian-tumors
#1
Alessandro Villanucci, Ketty Tavella, Laura Vannini, Virginia Rossi, Stefania Nobili, Gianni Amunni, Teresita Mazzei, Enrico Mini
The majority of patients with ovarian cancer will experience relapse and thus require second-line therapy. While platinum-based therapies are the primary treatments for refractory disease other options are required, particularly for those with partially platinum-sensitive disease as their response rates are lower. Agents that can resensitize relapsed ovarian cancers to platinum, including trabectedin, are therefore of increasing interest. Trabectedin is a multitarget agent that has a complex, novel mechanism of action and has exhibited promising results in platinum-sensitive ovarian cancer when in combination with pegylated liposomal doxorubicin (PLD)...
December 2018: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/30542522/serous-cystadenoma-of-pancreas-a-clinicopathologic-experience-of-23-cases-from-a-major-tertiary-care-center
#2
Muhammad Usman Tariq, Zubair Ahmad, Jamshid Abdul-Ghafar, Nasir Ud Din
Background: Serous cystadenomas of pancreas are rare benign epithelial neoplasms, which predominantly occur in the pancreatic body and tail of elderly females. Majority of these tumors have microcystic appearance. Macrocystic and solid variants have also been described. A number of more aggressive cystic pancreatic lesions are included in the differential diagnosis. Distinction from such lesions is important for optimal management. Objective: Our aim was to study the clinical and histological features of serous cystadenomas which would be helpful in making their correct diagnosis and understanding their behavior...
2018: Rare Tumors
https://www.readbyqxmd.com/read/30542485/berberine-reduces-the-occurrence-of-neonatal-necrotizing-enterocolitis-by-reducing-the-inflammatory-response
#3
Yong Jing, Fudong Peng, Yufeng Shan, Jingkai Jiang
Necrotizing enterocolitis (NEC) is a life-threatening disease that occurs in premature infants. The aim of the present study was to investigate the effects of berberine, an isoquinoline alkaloid mainly used to treat digestive diseases, in a rat model of NEC. NEC models were established in newborn rats via inhalation of N2 for 90 sec every 4 h and oral administration of 4 mg/kg/day lipopolysaccharides on days 0 and 1. Berberine was administered via oral gavage. In the NEC model group, Toll-like receptor (TLR)4, nuclear factor NF-κB (NF-κB), inducible nitric oxide synthase (iNOS), tumor necrosis factor (TNF)-α, interleukin (IL)-6 and IL-10 were upregulated...
December 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/30540681/diagnostic-and-prognostic-impact-of-neutrophil-to-lymphocyte-ratio-for-intraductal-papillary-mucinous-neoplasms-of-the-pancreas-with-high-grade-dysplasia-and-associated-invasive-carcinoma
#4
Tatsuo Hata, Masamichi Mizuma, Fuyuhiko Motoi, Masaharu Ishida, Takanori Morikawa, Tatsuyuki Takadate, Kei Nakagawa, Hiroki Hayashi, Atsushi Kanno, Atsushi Masamune, Takashi Kamei, Toru Furukawa, Takeshi Naitoh, Michiaki Unno
OBJECTIVES: The aim of this study was to evaluate the diagnostic and prognostic impact of systemic inflammatory markers for IPMN with high-grade dysplasia (HGD)/invasive carcinoma. METHODS: Neutrophil-to-lymphocyte ratio (NLR), derived NLR, platelet-to-lymphocyte ratio, and C-reactive protein-to-albumin ratio were compared across the different histological grades of 205 IPMN cases. We also tested the diagnostic performance for IPMN with HGD/invasive carcinoma. RESULTS: The median (interquartile range) preoperative NLR was higher in IPMN with HGD/invasive carcinoma (2...
January 2019: Pancreas
https://www.readbyqxmd.com/read/30539491/sites-of-recurrence-after-complete-cytoreduction-and-hyperthermic-intraperitoneal-chemotherapy-for-patients-with-peritoneal-carcinomatosis-from-colorectal-and-appendiceal-adenocarcinoma-a-tertiary-center-experience
#5
Yael Feferman, Daniel Solomon, Shanel Bhagwandin, Joseph Kim, Samantha N Aycart, Daniela Feingold, Umut Sarpel, Daniel M Labow
BACKGROUND: This report describes patterns of disease recurrence after optimal cytoreduction (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) for peritoneal carcinomatosis (PC) of colorectal (CRC) and appendiceal adenocarcinoma (AC) origin. METHODS: Patients undergoing optimal CRS/HIPEC (2007-2016) at the authors' institution were retrospectively reviewed from a prospectively maintained database. Data regarding disease recurrence were analyzed. RESULTS: Of 74 patients who underwent CRS/HIPEC for PC from CRC (n = 46) or AC (n = 28), 49 (66%) had recurrence during a median follow-up period of 39...
December 11, 2018: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/30538291/results-of-first-round-of-surveillance-in-individuals-at-high-risk-of-pancreatic-cancer-from-the-aisp-italian-association-for-the-study-of-the-pancreas-registry
#6
Salvatore Paiella, Gabriele Capurso, Giulia Martina Cavestro, Giovanni Butturini, Raffaele Pezzilli, Roberto Salvia, Marianna Signoretti, Stefano Crippa, Silvia Carrara, Isabella Frigerio, Claudio Bassi, Massimo Falconi, Elsa Iannicelli, Alessandro Giardino, Alessandro Mannucci, Andrea Laghi, Luigi Laghi, Luca Frulloni, Alessandro Zerbi
INTRODUCTION: Surveillance programs on high-risk individuals (HRIs) can detect pre-malignant lesions or early pancreatic cancer (PC). We report the results of the first screening round of the Italian multicenter program supported by the Italian Association for the study of the Pancreas (AISP). METHODS: The multicenter surveillance program included asymptomatic HRIs with familial (FPC) or genetic frailty (GS: BRCA1/2, p16/CDKN2A, STK11/LKB1or PRSS1, mutated genes) predisposition to PC...
December 11, 2018: American Journal of Gastroenterology
https://www.readbyqxmd.com/read/30536902/calcitonin-administration-improves-endometrial-receptivity-via-regulation-of-lif-muc-1-and-microrna-let-7a-in-mice
#7
Naser Shokrzadeh, Mohammad Reza Alivand, Ali Abedelahi, Mohammad B Hessam Shariati, Behrooz Niknafs
Calcitonin (CT) is one of the factors affecting the embryo implantation, but its effects on the implantation window have not been fully investigated. The current study investigated the effects of CT on the endometrium receptivity by morphological study and evaluation of leukemia inhibitory factor (LIF), mucin 1 (Muc-1), and microRNA (miRNA) Let-7a in the ovarian stimulation and the normal ovarian cycle. Then the mechanism of the CT effects through the mammalian target of rapamycin (mTOR) signaling pathway was studied by using PP242...
December 8, 2018: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/30532686/selection-of-fast-and-slow-growing-bacteria-from-fecal-microbiota-using-continuous-culture-with-changing-dilution-rate
#8
K Adamberg, S Adamberg
Background : Nutrient and energy metabolism in human colon depends on bacterial growth rate that is determined by the colonic transit rate. Objective : A novel approach, De-stat culture was used to distinguish the fast and slow growing sub-populations from fecal microbiota. Design : The enrichment and metabolism of bacteria from pooled fecal cultures of children was studied at dilution rates D  = 0.2-0.0 1/h in mucin-supplemented media containing either arabinogalactan or apple pectin. Results : The study revealed clear differentiation of the fecal microbiota at higher (above 0...
2018: Microbial Ecology in Health and Disease
https://www.readbyqxmd.com/read/30531114/-a-case-of-cholangiolocellular-carcinoma-found-to-be-hepatic-hemangioma-at-16-month-follow-up
#9
Katsutoshi Yamaguchi, Yasuyuki Nagao, Satoki Yamane, Keisuke Takemura, Tatsuro Oaku, Yuma Hotta, Nobuhisa Yamada, Satoru Sekoguchi, Yutaka Isozaki, Hirokazu Oyamada
We report a rare case of hepatic cholangiolocellular carcinoma (CoCC) with long-term observation. A 73-year-old woman was found to have a solitary hepatic tumor with a diameter of 10mm on dynamic computed tomography (CT), which showed peripheral enhancement in the arterial phase and enhancement retention in the delayed phase. Although it was initially diagnosed as hepatic hemangioma, the follow up examination conducted 16 months later revealed that the tumor had grown to 18mm. Doubling time of the tumor was calculated to be 177 days...
2018: Nihon Shokakibyo Gakkai Zasshi, the Japanese Journal of Gastro-enterology
https://www.readbyqxmd.com/read/30529606/identification-of-salivary-peptidomic-biomarkers-in-chronic-kidney-disease-patients-undergoing-haemodialysis
#10
Peiyuan Tong, Chao Yuan, Xiangyu Sun, Qi Yue, Xiaoling Wang, Shuguo Zheng
BACKGROUND: Chronic kidney disease (CKD) is a worldwide public health problem. To detect discriminating salivary peptide profiles between CKD patients undergoing haemodialysis (HD) and healthy controls (HCs) and to screen candidate biomarkers for CKD, we preliminarily explored the diagnostic potentiality of saliva. METHODS: Saliva samples from 30 CKD HD patients and 35 HCs were analysed using matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) combined with weak cation exchange magnetic beads...
December 7, 2018: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/30528888/disseminating-universal-genetic-testing-to-a-diverse-indigent-patient-population-at-a-county-hospital-gynecologic-oncology-clinic
#11
Erica M Bednar, Charlotte C Sun, Bethsaida Camacho, John Terrell, Alyssa G Rieber, Lois M Ramondetta, Ralph S Freedman, Karen H Lu
OBJECTIVE: The universal genetic testing initiative (UGTI) is a quality improvement effort to increase rates of guideline-based genetic counseling (GC) and genetic testing (GT) of patients with potentially hereditary cancers. The UGTI was disseminated to a county hospital gynecologic oncology clinic that serves a diverse, indigent patient population. METHODS: Using the Model for Improvement quality improvement framework, interventions including integrated GC, clinic tracking, assisted GC referrals, and provider education were tested over 26 months...
December 8, 2018: Gynecologic Oncology
https://www.readbyqxmd.com/read/30527813/intestinal-mucus-is-capable-of-stabilizing-supersaturation-of-poorly-water-soluble-drugs
#12
Yan Yan Yeap, Jaclyn Lock, Sean Lerkvikarn, Tanner Semin, Nicholas Nguyen, Rebecca L Carrier
The utilization of polymers to stabilize drug supersaturation and enhance oral drug absorption has recently garnered considerable interest. The potential role of intestinal mucus in stabilizing drug supersaturation, however, has not been previously explored. The ability for intestinal mucus to stabilize drug supersaturation and delay drug precipitation is potentially useful in enhancing the absorption of orally dosed compounds from drug delivery systems that generate supersaturation within the gastrointestinal tract (e...
December 6, 2018: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/30523643/inhibition-of-muc1-c-regulates-metabolism-by-akt-pathway-in-esophageal-squamous-cell-carcinoma
#13
Xin GongSun, YongQiang Zhao, Bin Jiang, ZhongWei Xin, Mo Shi, Liang Song, QiMing Qin, Qiang Wang, XiangYan Liu
Esophageal squamous cell carcinoma (ESCC) is one of the most common digestive tumors worldwide. The Mucin 1 (MUC1) heterodimeric protein has been confirmed that is overexpressed in ESCC and induced adverse outcomes. However, the detailed mechanism(s) remained challenging. So, we investigated the relationship between MUC1-C and metabolism in ESCC cells. In the results, TP53-induced glycolysis and apoptosis regulator (TIGAR) was overexpressed and correlative with MUC1-C positively in ESCC tissue. Targeting MUC1-C inhibits AKT-mTORC-S6K1 signaling and blocks TIGAR translation...
December 6, 2018: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/30523470/outcomes-in-peritoneal-dissemination-from-signet-ring-cell-carcinoma-of-the-appendix-treated-with-cytoreductive-surgery-and-hyperthermic-intraperitoneal-chemotherapy
#14
Carlos Munoz-Zuluaga, Armando Sardi, Mary Caitlin King, Carol Nieroda, Michelle Sittig, Ryan MacDonald, Vadim Gushchin
BACKGROUND: Cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (CRS/HIPEC) is standard treatment for peritoneal dissemination from appendiceal cancer (AC); however, its role in high-grade histopathologic subtypes (high-grade mucinous carcinoma peritonei [HGMCP] and HGMCP with signet ring cells [HGMCP-S]) is controversial due to their aggressive behavior. This study analyzed clinical outcomes of high-grade AC after CRS/HIPEC. METHODS: A prospective database of CRS/HIPEC procedures for HGMCP performed from 1998-2017 was reviewed...
December 6, 2018: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/30513627/genomic-characteristics-of-invasive-mucinous-adenocarcinomas-of-the-lung-and-potential-therapeutic-targets-of-b7-h3
#15
Takahiro Nakagomi, Taichiro Goto, Yosuke Hirotsu, Daichi Shikata, Yujiro Yokoyama, Rumi Higuchi, Sotaro Otake, Kenji Amemiya, Toshio Oyama, Hitoshi Mochizuki, Masao Omata
Pulmonary invasive mucinous adenocarcinoma (IMA) is considered a variant of lung adenocarcinomas based on the current World Health Organization classification of lung tumors. However, the molecular mechanism driving IMA development and progression is not well understood. Thus, we surveyed the genomic characteristics of IMA in association with immune-checkpoint expression to investigate new potential therapeutic strategies. Tumor cells were collected from surgical specimens of primary IMA, and sequenced to survey 53 genes associated with lung cancer...
November 30, 2018: Cancers
https://www.readbyqxmd.com/read/30513286/resolvin-d1-but-not-resolvin-e1-transactivates-the-epidermal-growth-factor-receptor-to-increase-intracellular-calcium-and-glycoconjugate-secretion-in-rat-and-human-conjunctival-goblet-cells
#16
Rebecca Kaye, Nora Botten, Marit Lippestad, Dayu Li, Robin R Hodges, Tor P Utheim, Charles N Serhan, Darlene A Dartt
PURPOSE: To identify interactions of the epidermal growth factor receptor (EGFR) with the pro-resolving mediator receptors for RvD1 and RvE1 to stimulate an increase in intracellular [Ca2+ ] ([Ca2+ ]i ) and mucin secretion from cultured human and rat conjunctival goblet cells. METHODS: Goblet cells from human and rat conjunctiva were grown in culture using RPMI media. Cultured goblet cells were pre-incubated with inhibitors, and then stimulated with RvD1, RvE1, EGF or the cholinergic agonist carbachol (Cch)...
December 1, 2018: Experimental Eye Research
https://www.readbyqxmd.com/read/30511409/immune-checkpoint-blockade-opens-a-new-way-to-cancer-immunotherapy
#17
REVIEW
Sanam Sadreddini, Behzad Baradaran, Ali Aghebati-Maleki, Sevil Sadreddini, Dariush Shanehbandi, Ali Fotouhi, Leili Aghebati-Maleki
Among the main promising systems to triggering therapeutic antitumor immunity is the blockade of immune checkpoints. Immune checkpoint pathways regulate the control and eradication of infections, malignancies, and resistance against a host of autoantigens. Initiation point of the immune response is T cells, which have a critical role in this pathway. As several immune checkpoints are initiated by ligand-receptor interactions, they can be freely blocked by antibodies or modulated by recombinant forms of ligands or receptors...
December 3, 2018: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/30511046/effects-of-cdx2-on-prognosis-and-chemotherapy-responsiveness-in-mismatch-repair-deficient-colorectal-cancer
#18
É J Ryan, B Creavin, Y L Khaw, M E Kelly, H M Mohan, R Geraghty, E J Ryan, R Kennelly, A Hanly, S T Martin, D Fennelly, R McDermott, D Gibbons, P R O'Connell, K Sheahan, D C Winter
Background: Caudal-related homeobox transcription factor 2 (CDX2) is an intestine-specific transcription factor implicated in tumour differentiation, proliferation, cell adhesion and migration. Negative CDX2 status (CDX2-) is associated with worse prognosis in colorectal cancer and may identify high-risk stage II disease that benefits from adjuvant chemotherapy. This observational study investigated whether CDX2- is associated with prognosis or response to chemotherapy in the mismatch repair-deficient (dMMR) phenotype of colorectal cancer...
December 2018: BJS open
https://www.readbyqxmd.com/read/30509115/high-density-and-targeted-glycoproteomic-profiling-of-serum-proteins-in-pancreatic-cancer-and-intraductal-papillary-mucinous-neoplasm
#19
Linus Aronsson, Roland Andersson, Monika Bauden, Bodil Andersson, Thomas Bygott, Daniel Ansari
OBJECTIVE: Glycoproteomics is an emerging subfield of proteomics. Tumor-specific variations in protein glycosylation might be potential targets for the development of new cancer diagnostics. Here, we performed high-throughput screening and targeted verification of glycome alterations in serum samples from patients with pancreatic cancer and the precancerous lesion intraductal papillary mucinous neoplasm (IPMN). MATERIAL AND METHODS: The glycosylation profile of 1000 proteins was mapped in a discovery cohort comprising serum samples from 16 individuals, including 8 patients with pancreatic cancer and 8 healthy controls...
December 3, 2018: Scandinavian Journal of Gastroenterology
https://www.readbyqxmd.com/read/30506401/cellularity-in-low-grade-pseudomyxoma-peritonei-impacts-recurrence-free-survival-following-cytoreductive-surgery-and-hyperthermic-intraperitoneal-chemotherapy
#20
Philipp Horvath, Can Yurttas, Philipp Birk, Florian Struller, Alfred Königsrainer
PURPOSE: Documentation of cellularity in Pseudomyxoma peritonei (PMP) is not performed on a regular basis in everyday clinical practice, but is recommended by the PSOGI (Peritoneal Surface Oncology Group International). We investigated the impact of cellularity in PMP following cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) on recurrence-free survival. METHODS: Data from 25 patients with low-grade (American Joint Committee on Cancer grade G1) PMP were retrospectively evaluated...
December 1, 2018: Langenbeck's Archives of Surgery
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