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Mucin 1

Tong Gao, Yi Yu, Qing Cong, Yisheng Wang, Mingming Sun, Liangqing Yao, Congjian Xu, Wei Jiang
BACKGROUND: The tumour microenvironment conferred by mesenchymal stem cells (MSCs) plays a key role in tumour development and progression. We previously determined that platelet-activating factor receptor (PAFR) was overexpressed in ovarian cancer cells (OCCs) and that PAF can promote ovarian cancer progression via PAF/PAFR-mediated inflammatory signalling pathways. Evidence suggests that MSCs can secrete high concentrations of PAF. Here, we investigated the role of PAF/PAFR signalling in the microenvironment mediated by MSCs and OCCs and its effect on cancer progression...
October 19, 2018: BMC Cancer
Álvaro Fernández-Montero, Silvia Torrecillas, Marisol Izquierdo, María José Caballero, Douglas John Milne, Christopher John Secombes, John Sweetman, Polyana Da Silva, Félix Acosta, Daniel Montero
The main objective of this study was to determine the effect of two forms of mannan oligosaccharides (MOS: Bio-Mos® and cMOS: Actigen® , Alltech Inc, USA) and their combination on greater amberjack (Seriola dumerili) growth performance and feed efficiency, immune parameters and resistance against ectoparasite (Neobenedenia girellae) infection. Fish were fed for 90 days with 5 g kg-1 MOS, 2 g kg-1 cMOS or a combination of both prebiotics, in a Seriola commercial base diet (Skretting, Norway). At the end of the feeding period, no differences were found in growth performance or feed efficiency...
October 16, 2018: Fish & Shellfish Immunology
Sercan Karav, Giorgio Casaburi, Steven A Frese
Mucin glycoproteins play an important role in protecting the gut epithelium by keeping gut microbes from direct contact with the gut epithelium while allowing for diffusion of small molecules from the lumen to the epithelium. The mucin glycocalyx can be degraded by gut bacteria such as Bacteroides and Akkermansia , but other bacteria, such as Bifidobacterium longum subsp . Infantis , cannot consume mucin glycans. Untargeted mass spectrometry profiles were compared to microbiome profiles to assess how different gut microbiomes affect colonic mucin degradation...
October 2018: FEBS Open Bio
Núria Piqué, Barbara De Servi
Background: To assess the effects of Rhinosectan® spray, a medical device containing xyloglucan, on nasal ciliary function (in MucilAir™Nasal cells). Methods: MucilAir™Nasal, a three-dimensional organotypic airway tissue model (with different cell types), was treated with Rhinosectan® (30 µl) or with a control (saline solution). The effects of Rhinosectan® were evaluated at 15 and 60 min post-exposure by: measurement of the cilia beating frequency (Hz), mucin detection (Enzyme-Linked Lectin Assay-ELLA), mucociliary clearance (µm/s) and phagocytosis assay (fluorescence)...
2018: Allergy, Asthma, and Clinical Immunology
Min Han Kim, Chang Hoon Bae, Yoon Seok Choi, Hyung Gyun Na, Si-Youn Song, Yong-Dae Kim
Objectives: Endoplasmic reticulum (ER) stress is known to be associated with inflammatory airway diseases, and three major transmembrane receptors: double-stranded RNA-activated protein kinase-like ER kinase, inositol requiring enzyme 1, and activating transcription factor 6 (ATF6) play important roles in ER stress-related proinflammatory signaling. However, the effects of ER stress and these three major signaling pathways on the regulation of the production of airway mucins in human nasal airway epithelial cells have not been elucidated...
October 20, 2018: Clinical and Experimental Otorhinolaryngology
Akiko Suzuki, Junichi Iwata
Every day, salivary glands produce about 0.5 to 1.5 L of saliva, which contains salivary proteins that are essential for oral health. The contents of saliva, 0.3% proteins (1.5 to 4.5 g) in fluid, help prevent oral infections, provide lubrication, aid digestion, and maintain oral health. Acinar cells in the lobular salivary glands secrete prepackaged secretory granules that contain salivary components such as amylase, mucins, and immunoglobulins. Despite the important physiological functions of salivary proteins, we know very little about the regulatory mechanisms of their secretion via exocytosis, which is a process essential for the secretion of functional proteins, not only in salivary glands, but also in other secretory organs, including lacrimal and mammary glands, the pancreas, and prostate...
October 17, 2018: International Journal of Molecular Sciences
Wesley P Schweer, Eric R Burrough, John F Patience, Brian J Kerr, Nicholas K Gabler
Brachyspira hyodysenteriae (Bhyo) induces mucohemorrhagic diarrhea in pigs and is an economically significant disease worldwide. Our objectives were to determine the impact of Bhyo on apparent total tract digestibility (ATTD), ileal digestibility (AID), and ileal basal endogenous losses (BEL) in grower pigs. In addition, we assessed the effect of Bhyo on hindgut disappearance of DM, N, and GE. Thirty-two Bhyo negative gilts (38.6 ± 0.70 kg BW) were fitted with a T-cannula in the distal ileum and individually penned...
October 17, 2018: Journal of Animal Science
Yun-Xia Zhao, Hui-Ran Zhang, Xiu-Na Yang, Yu-Hao Zhang, Shan Feng, Feng-Xue Yu, Xi-Xin Yan
Background: Fine particulate matter (PM2.5 ) exacerbates airway inflammation and hyperreactivity in patients with asthma, but the mechanism remains unclear. The aim of this study was to observe the effects of prolonged exposure to high concentrations of PM2.5 on the pathology and airway hyperresponsiveness (AHR) of BALB/c mice undergoing sensitization and challenge with ovalbumin (OVA) and to observe the effects of apoptosis and T-cell immunoglobulin and mucin domain 1 (TIM-1) in this process...
October 20, 2018: Chinese Medical Journal
Jin Song, Lori J Sokoll, Jered J Pasay, Abigail L Rubin, Hanying Li, Dylan M Bach, Daniel W Chan, Zhen Zhang
BACKGROUND: Pancreatic cancer is a deadly disease for which available biomarkers, such as CA19-9, lack the desired sensitivity and specificity for early detection. Additional biomarkers are needed to improve both its sensitivity and specificity. METHODS: Multiplex immunoassays were developed for selected biomarkers using a Bio-Plex 200 system and analytical performance optimized. All proteins were analyzed in sera of patients diagnosed with pancreatic ductal adenocarcinoma (PDAC, n=188) or benign pancreatic conditions (131), and healthy controls (89)...
October 17, 2018: Cancer Epidemiology, Biomarkers & Prevention
Yuichiro Kai, Vishwa Jeet Amatya, Kei Kushitani, Takahiro Kambara, Rui Suzuki, Yasuhiro Tsutani, Yoshihiro Miyata, Morihito Okada, Yukio Takeshima
AIMS: The process of differential diagnosis between epithelioid mesothelioma and lung adenocarcinoma has been progressing; however, there are no absolute immunohistochemical markers to definitively diagnose epithelioid mesothelioma. The aim of this study was to search for a novel negative marker of epithelioid mesothelioma. MATERIALS AND METHODS: We immunohistochemically studied the applicability of mucin 21 (MUC21), which was identified in our previous study, as a novel, negative diagnostic marker for epithelioid mesothelioma...
October 17, 2018: Histopathology
Inhee Moon, Hyun Goo Kang, Areum Yeo, Hyemi Noh, Hyeon Chang Kim, Jong Suk Song, Yong Woo Ji, Hyung Keun Lee
PURPOSE: To determine the mucinogenic effect of dry eye (DE) treatment drugs currently in use, we compared the levels of mucin production and inflammatory cytokine expression on the ocular surfaces using a DE-induced mice model. METHODS: C57BL/6 mice were separated into 6 groups: a control group, DE-induced mice with the vehicle and treated with cyclosporine A (CsA), rebamipide (Reb), diquafosol tetrasodium (DQS), or prednisolone (Pred). The mRNA expression of MUC 1, 4, 16, 5AC, and proinflammatory cytokines on the corneal epithelia were determined by quantitative real-time polymerase chain reaction...
October 16, 2018: Journal of Ocular Pharmacology and Therapeutics
A L B Moreira Filho, P R Ferket, R D Malheiros, C J B Oliveira, P C Aristimunha, D E Wilsmann, P E N Givisiez
The effects of in ovo feeding with threonine (Thr) on intestinal morphology, ileal gene expression and performance of broiler chicken between 1 and 21 d of age (d) were assessed. On day 17.5 of incubation, fertile eggs were randomly allotted to 5 treatments of Thr injection in the amniotic fluid (0; 1.75; 3.5; 5.25; 7%, corresponding to 17.5; 35; 52.5 and 70 mg Thr/mL). After hatch, chicks were given a commercial corn-soybean diet up to 21 d. Daily feed intake (FI), body weight (BW), and food conversion ratio (FCR) were measured from 1 to 7, 14, and 21 d of age...
October 15, 2018: Poultry Science
David Dunkin, Alina C Iuga, Sanda Mimouna, Carolyn L Harris, Jean-Vianney Haure-Mirande, Dominique Bozec, Garabet Yeretssian, Stephanie Dahan
Increasing evidence links Notch-1 signaling with the maintenance of intestinal architecture and homeostasis. Dysfunction in the common Notch-1 pathway transcription factor recombinant binding protein suppressor of hairless (RBP-J) is associated with loss of epithelial barrier integrity and aberrant conversion of proliferative crypt cells into goblet cells. Furthermore, we have recently discovered that epithelial Notch-1 is indispensable in bridging innate and adaptive immunity in the gut and is required for supporting protective epithelial pro-inflammatory responses...
September 11, 2018: Oncotarget
Tatyana Milman, Codrin Iacob, Simeon Lauer, Michael D Feldman, Paul J L Zhang
Neoplasms arising in accessory lacrimal glands are rare. We describe a 33-year-old man with adenocarcinoma arising in the left lower eyelid accessory lacrimal gland. Microscopic evaluation demonstrated an infiltrative neoplasm composed of mildly to moderately pleomorphic cells with abundant eosinophilic cytoplasm and focal intracytoplasmic vacuoles, arranged predominantly in ductules. Foci of luminal and intracytoplasmic eosinophilic secretory material and occasional mucin were noted. An in situ component was identified in the gland of Wolfring...
September 2018: Ocular Oncology and Pathology
Min Seo Kim, Ji Yeon Kim
This study assessed the anti-inflammatory effect of ginger extract on colitis by 5% dextran sulfate sodium (DSS) in BALB/c mice. The mice were administered either distilled water or three doses of ginger extracts for 21 days. We evaluated the change in clinical and histopathological signs and cytokine and gene expression levels. Contrary to the DSS group, the ginger groups increased body weight and inhibited shortening of the colon. DAI values and colon injury in the ginger groups were lower than that in the DSS group...
October 2018: Food Science and Biotechnology
Masoud Najafi, Bagher Farhood, Keywan Mortezaee
Regulatory T cells (Tregs) represent a low number of T-cell population under normal conditions, and they play key roles for maintaining immune system in homeostasis. The number of these cells is extensively increased in nearly all cancers, which is for dampening responses from immune system against cancer cells, metastasis, tumor recurrence, and treatment resistance. The interesting point is that apoptotic Tregs are stronger than their live counterparts for suppressing responses from immune system. Tregs within the tumor microenvironment have extensive positive cross-talks with other immunosuppressive cells including cancer-associated fibroblasts, cancer cells, macrophage type 2 cells, and myeloid-derived suppressor cells, and they have negative interactions with immunostimulatory cells including cytotoxic T lymphocytes (CTL) and natural killer cells...
October 14, 2018: Journal of Cellular Physiology
Khadija El Jellas, Bente B Johansson, Karianne Fjeld, Aristotelis Antonopoulos, Heike Immervoll, Man H Choi, Dag Hoem, Mark E Lowe, Dominique Lombardo, Pål R Njølstad, Anne Dell, Eric Mas, Stuart M Haslam, Anders Molven
Carboxyl-ester lipase (CEL) is a pancreatic fat-digesting enzyme associated with human disease. Rare mutations in the CEL gene cause a syndrome of pancreatic exocrine and endocrine dysfunction denoted MODY8, whereas a recombined CEL allele increases the risk for chronic pancreatitis. Moreover, CEL has been linked to pancreatic ductal adenocarcinoma (PDAC) through a postulated oncofetal CEL variant termed feto-acinar pancreatic protein (FAPP). The monoclonal antibody mAb16D10 was previously reported to detect a glycotope in the highly O-glycosylated, mucin-like C-terminus of CEL/FAPP...
October 12, 2018: Journal of Biological Chemistry
Rei Suzuki, Hiroki Irie, Tadayuki Takagi, Mitsuru Sugimoto, Naoki Konno, Yuki Sato, Ko Watanabe, Jun Nakamura, Shigeru Marubashi, Takuto Hikichi, Hiromasa Ohira
BACKGROUND: Endoscopic ultrasound-guided fine needle aspiration (EUS-FNA) for mucinous cystic neoplasm of the pancreas carries a potential risk of inducing peritoneal tumor cell dissemination. We investigated the diagnostic yield and safety of EUS-FNA-based cytology of cells obtained from the pancreatic invasion site of intraductal papillary-mucinous neoplasm-derived adenocarcinoma (IPMC). METHODS: We included 22 surgically resected IPMCs and 84 pancreatic ductal adenocarcinomas (PDACs)...
October 12, 2018: BMC Cancer
Ryuichiro Kimura, Azusa Yoneshige, Man Hagiyama, Tomoyuki Otani, Takao Inoue, Naoki Shiraishi, Kazuyoshi Yanagihara, Tomohiko Wakayama, Akihiko Ito
AIMS: To determine cellular distribution of cell adhesion molecule 1 (CADM1), an immunoglobulin superfamily member, in the human oxyntic gastric mucosa, and to explore possible involvement in the development and peritoneal dissemination of signet ring cell (SRC) gastric carcinoma, which often develops in the oxyntic mucosa. MAIN METHODS: Immunohistochemistry and double immunofluorescence were conducted on surgical specimens of normal and SRC-bearing stomachs and peritoneal metastatic foci of SRCs...
October 9, 2018: Life Sciences
Tsung-Hsing Chen, Wey-Ran Lin, Chieh Lee, Cheng-Tang Chiu, Jun-Te Hsu, Ta-Sen Yeh, Kwang-Huei Lin, Puo-Hsien Le, Chau-Ting Yeh
Background: Gastric signet ring cell carcinoma (SRCC) is a histologic variant characterized by abundant intracytoplasmic mucin. Although it has been recognized that gastric adenocarcinoma harboring this feature has poorer prognosis, prognostic stratification within gastric SRCCs themselves has not been clearly defined. N-acetylgalactosaminyltransferase14 (GALNT14) genotype has been associated to poorer treatment outcome in mucinous type colorectal cancer. Here we incorporated clinicopathological factors and GALNT14 genotype to stratify prognosis of advanced gastric SRCC...
2018: Journal of Cancer
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