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https://www.readbyqxmd.com/read/28535592/stream-salinization-and-fungal-mediated-leaf-decomposition-a-microcosm-study
#1
Cristina Canhoto, Sara Simões, Ana Lúcia Gonçalves, Lúcia Guilhermino, Felix Bärlocher
Salinization is of major global concern due to its effect on stream biota, and ecosystem functions and services. In small streams, litter decomposition is a key ecosystem-level process driven by decomposers, mainly fungi (aquatic hyphomycetes), which link litter and invertebrates. Here we assessed the effects of an environmentally relevant range of salt additions (0, 2, 4, 8, 16gL(-1) NaCl) on (1) fungal growth and species-specific reproductive output and (2) fungal mediated-decomposition of Quercus robur leaves...
May 19, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28535331/computer-and-mobile-technology-interventions-for-self-management-in-chronic-obstructive-pulmonary-disease
#2
REVIEW
Catherine McCabe, Margaret McCann, Anne Marie Brady
BACKGROUND: Chronic obstructive pulmonary disease (COPD) is characterised by airflow obstruction due to an abnormal inflammatory response of the lungs to noxious particles or gases, for example, cigarette smoke. The pattern of care for people with moderate to very severe COPD often involves regular lengthy hospital admissions, which result in high healthcare costs and an undesirable effect on quality of life. Research over the past decade has focused on innovative methods for developing enabling and assistive technologies that facilitate patient self-management...
May 23, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28534272/braf-mutation-is-associated-with-an-improved-survival-in-glioma-a-systematic-review-and-meta-analysis
#3
REVIEW
Huy Gia Vuong, Ahmed M A Altibi, Uyen N P Duong, Hanh T T Ngo, Thong Quang Pham, Kar-Ming Fung, Lewis Hassell
Newly emerged molecular markers in gliomas provide prognostic values beyond the capabilities of histologic classification. BRAF mutation, especially BRAF V600E, is common in a subset of gliomas and may represent a potential prognostic marker. The aim of our study is to investigate the potential use of BRAF mutations on prognosis of glioma patients. Four electronic databases were searched for potential articles, including PubMed, Scopus, ISI Web of Science, and Virtual Health Library (VHL). Data of hazard ratio (HR) for overall survival (OS) and progression-free survival (PFS) were directly obtained from original papers or indirectly estimated from Kaplan Meier curve (KMC)...
May 22, 2017: Molecular Neurobiology
https://www.readbyqxmd.com/read/28533536/a-systemic-review-and-an-updated-meta-analysis-minimally-invasive-vs-open-pancreaticoduodenectomy
#4
Zhanwei Zhao, Zifang Yin, Zhenning Hang, Gang Ji, Quanxin Feng, Qingchuan Zhao
The feasible of minimally invasive pancreaticoduodenectomy (MIPD) remains controversial when compared with open pancreaticoduodenectomy (OPD). We conducted a systemic review and meta-analysis to summarise the available evidence to compare MIPD vs OPD. We systemically searched PubMed, EMBASE and Web of Science for studies published through February 2016. The primary endpoint was postoperative pancreatic fistula (POPF, grade B/C). A total of 27 studies involving 14,231 patients (2,377 MIPD and 11,854 OPD) were included...
May 22, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28533426/a-reappraised-meta-analysis-of-the-genetic-association-between-vitamin-d-receptor-bsm-i-rs1544410-polymorphism-and-pulmonary-tuberculosis-risk
#5
Mohammed Y Areeshi, Raju K Mandal, Sajad Ahmad Dar, Abdulrahman M Alshahrani, Aqeel Ahmad, Arshad Jawed, Mohd Wahid, Mohtashim Lohani, Aditya K Panda, Shafiul Haque
BsmI (rs1544410) polymorphism located in intron 8 at the 3' end of the VDR gene is known to be involved in the regulation of mRNA stability. Many studies evaluated the possible correlation between VDR Bsm I polymorphism and the risk of pulmonary tuberculosis (PTB), and reported conflicting results. In this study, an updated meta-analysis was performed to evaluate the above said association. PubMed, EMBASE, and Google Scholar web-databases were searched for the relevant studies and a meta-analysis was performed by calculating pooled odds ratios (ORs) and 95% confidence intervals (95% CIs) for all the genetic models...
May 22, 2017: Bioscience Reports
https://www.readbyqxmd.com/read/28533424/comparison%C3%A2-of%C3%A2-efficacy%C3%A2-and%C3%A2-safety%C3%A2-between%C3%A2-dezocine-and%C3%A2-morphine-for-persistence-of-pain-in-cancer-patients-in-chinese-a-meta-analysis
#6
Lei Wang, Xudong Liu, Jianfeng Wang, Yingjiao Sun, Guozhuan Zhang, Lishuang Liang
   The association between the efficacy and safety of dezocine injection and morphine injection for persistence of pain in patients with cancer had yielded controversial results. Therefore, we conduct a meta-analysis of existing observational published studies to assess the relationship between them among Chinese. We conducted a comprehensive research from the databases of PubMed, Web of Science and Wan Fang Med Online for the related studies up to October 2016. Summary odds ratio (OR) with 95% confidence interval (95% CI) were calculated with the random effects model...
May 22, 2017: Bioscience Reports
https://www.readbyqxmd.com/read/28533329/pregnancy-outcome-after-first-trimester-use-of-methyldopa-a-prospective-cohort-study
#7
Maria Hoeltzenbein, Evelin Beck, Anne-Katrin Fietz, Juliane Wernicke, Sandra Zinke, Angela Kayser, Stephanie Padberg, Corinna Weber-Schoendorfer, Reinhard Meister, Christof Schaefer
Published experience on first trimester exposure to methyldopa is still limited, although it is recommended as first-line treatment for hypertensive disorders in pregnancy in most countries. The primary aim of this prospective observational cohort study was to analyze the rate of major birth defects and spontaneous abortions in women with methyldopa therapy for chronic hypertension. Outcomes of 261 pregnancies with first trimester exposure to methyldopa and 526 comparison pregnancies without chronic hypertension reported to the German Embryotox pharmacovigilance institute were evaluated...
May 22, 2017: Hypertension
https://www.readbyqxmd.com/read/28532537/-video-assisted-thoracoscope-versus-video-assisted-mini-thoracotomy-for-non-small-cell-lung-cancer-a-meta-analysis
#8
Bing Wang, Fang Lv, Liang Zhao, Minjun Du, Shugeng Gao
BACKGROUND: The aim of this study is to assess the effect of video-assisted thoracoscopic surgery (VATS) and video-assisted mini-thoracotomy (VAMT) in the treatment of non-small cell lung cancer (NSCLC). METHODS: We searched PubMed, EMbase, CNKI, VIP and ISI Web of Science to collect randomized controlled trials (RCTs) of VATS versus VAMT for NSCLC. Each database was searched from May 2006 to May 2016. Two reviewers independently assessed the quality of the included studies and extracted relevant data, using RevMan 5...
May 20, 2017: Zhongguo Fei Ai za Zhi, Chinese Journal of Lung Cancer
https://www.readbyqxmd.com/read/28529971/a-comparative-effectiveness-trial-of-three-walking-self-monitoring-strategies
#9
Caroline R Richardson, David E Goodrich, Angela R Larkin, David Ronis, Robert G Holleman, Laura J Damschroder, Julie C Lowery
PURPOSE: Walking programs improve health outcomes in adults at risk for cardiovascular disease and self-monitoring strategies can improve adherence to such programs. The objective of this study was to determine if a six-month internet-based walking program using web-enhanced pedometers results in more weight loss than walking programs based on time or simple pedometer-step count goals in adults with or at risk for cardiovascular disease (CVD). METHODS: This was a multi-site, randomized controlled trial of 255 male Veterans who were ambulatory, insufficiently active, BMI ≥ 28, and who reported 1 ≥ CVD risk factors...
November 2016: Translational Journal of the American College of Sports Medicine
https://www.readbyqxmd.com/read/28529195/rapid-web-based-platform-for-assessment-of-orthopedic-surgery-patient-care-milestones-a-2-year-validation
#10
Kenneth R Gundle, Dayne T Mickelson, Arien Cherones, Jason Black, Doug P Hanel
OBJECTIVE: To determine the validity, feasibility, and responsiveness of a new web-based platform for rapid milestone-based evaluations of orthopedic surgery residents. SETTING: Single academic medical center, including a trauma center and pediatrics tertiary hospital. PARTICIPANTS: Forty residents (PG1-5) in an orthopedic residency program and their faculty evaluators. METHODS: Residents and faculty were trained and supported in the use of a novel trainee-initiated web-based evaluation system...
May 18, 2017: Journal of Surgical Education
https://www.readbyqxmd.com/read/28528409/polychlorinated-biphenyl-related-alterations-of-the-expression-of-essential-genes-in-harbour-seals-phoca-vitulina-from-coastal-sites-in-canada-and-the-united-states
#11
Marie Noël, Neil Dangerfield, Steve Jeffries, Dyanna Lambourn, Monique Lance, Caren Helbing, Michel Lebeuf, Peter S Ross
As long-lived marine mammals found throughout the temperate coastal waters of the North Pacific and Atlantic Oceans, harbour seals (Phoca vitulina) have become an invaluable sentinel of food-web contamination. Their relatively high trophic position predisposes harbour seals to the accumulation of harmful levels of persistent organic pollutants (POPs). We obtained skin/blubber biopsy samples from live-captured young harbour seals from various sites in the northeastern Pacific (British Columbia, Canada, and Washington State, USA) as well as the northwestern Atlantic (Newfoundland and Quebec, Canada)...
May 20, 2017: Archives of Environmental Contamination and Toxicology
https://www.readbyqxmd.com/read/28528164/mri-derived-myocardial-strain-measures-in-normal-subjects
#12
Ha Q Vo, Thomas H Marwick, Kazuaki Negishi
OBJECTIVES: The aim of this study was to perform a systematic review and meta-analysis to estimate the normal ranges of magnetic resonance imaging (MRI)-based feature tracking (FT) and to identify sources of variations. Similar analyses were also performed for strain encoding, displacement encoding with stimulated echoes, and myocardial tagging. BACKGROUND: MRI-FT is a novel technique for quantification of myocardial deformation using MRI cine images. However, the reported 95% confidence intervals (CIs) from the 2 largest studies have no overlaps...
May 11, 2017: JACC. Cardiovascular Imaging
https://www.readbyqxmd.com/read/28526668/north-american-public-opinion-survey-on-the-acceptability-of-crowdsourcing-basic-life-support-for-out-of-hospital-cardiac-arrest-with-the-pulsepoint-mobile-phone-app
#13
Katie N Dainty, Haris Vaid, Steven C Brooks
BACKGROUND: The PulsePoint Respond app is a novel system that can be implemented in emergency dispatch centers to crowdsource basic life support (BLS) for patients with cardiac arrest and facilitate bystander cardiopulmonary resuscitation (CPR) and automated external defibrillator use while first responders are en route. OBJECTIVE: The aim of this study was to conduct a North American survey to evaluate the public perception of the above-mentioned strategy, including acceptability and willingness to respond to alerts...
May 17, 2017: JMIR MHealth and UHealth
https://www.readbyqxmd.com/read/28526538/trastuzumab-emtansine-versus-treatment-of-physician-s-choice-in-patients-with-previously-treated-her2-positive-metastatic-breast-cancer-th3resa-final-overall-survival-results-from-a-randomised-open-label-phase-3-trial
#14
Ian E Krop, Sung-Bae Kim, Antonio Gonzalez Martin, Patricia M LoRusso, Jean-Marc Ferrero, Tanja Badovinac-Crnjevic, Silke Hoersch, Melanie Smitt, Hans Wildiers
BACKGROUND: In the randomised, parallel assignment, open-label, phase 3 TH3RESA study, progression-free survival was significantly longer with trastuzumab emtansine versus treatment of physician's choice in previously treated patients with HER2-positive advanced breast cancer. We report results from the final overall survival analysis of the TH3RESA trial. METHODS: Eligible patients for the TH3RESA trial were men and women (aged ≥18 years) with centrally confirmed HER2-positive advanced breast cancer previously treated with both trastuzumab and lapatinib (advanced setting) and a taxane (any setting) and with progression on two or more HER2-directed regimens in the advanced setting...
May 16, 2017: Lancet Oncology
https://www.readbyqxmd.com/read/28526115/different-life-cycle-strategies-of-the-dinoflagellates-fragilidium-duplocampanaeforme-and-its-prey-dinophysis-acuminata-may-explain-their-different-susceptibilities-to-the-infection-by-the-parasite-parvilucifera-infectans
#15
Bora Lee, Myung Gil Park
Some marine dinoflagellates form ecdysal cyst (=temporary cysts) as part of their life cycle or under unfavorable growth conditions. Whether the dinoflagellates form ecdysal cysts or not may influence susceptibility to parasitism. In this study, parasite prevalence relative to inoculum size of the parasitoid Parvilucifera infectans zoospores for two dinoflagellate hosts (i.e., Fragilidium duplocampanaeforme and Dinophysis acuminata), which have different life cycle strategies, was examined. Further, susceptibility of cysts to parasitism, encystment signal, duration of encystments, and effects of induced encystment on diel periodicity, using ecdysal cyst-forming F...
May 2017: Harmful Algae
https://www.readbyqxmd.com/read/28524930/nutrition-support-in-hospitalised-adults-at-nutritional-risk
#16
REVIEW
Joshua Feinberg, Emil Eik Nielsen, Steven Kwasi Korang, Kirstine Halberg Engell, Marie Skøtt Nielsen, Kang Zhang, Maria Didriksen, Lisbeth Lund, Niklas Lindahl, Sara Hallum, Ning Liang, Wenjing Xiong, Xuemei Yang, Pernille Brunsgaard, Alexandre Garioud, Sanam Safi, Jane Lindschou, Jens Kondrup, Christian Gluud, Janus C Jakobsen
BACKGROUND: The prevalence of disease-related malnutrition in Western European hospitals is estimated to be about 30%. There is no consensus whether poor nutritional status causes poorer clinical outcome or if it is merely associated with it. The intention with all forms of nutrition support is to increase uptake of essential nutrients and improve clinical outcome. Previous reviews have shown conflicting results with regard to the effects of nutrition support. OBJECTIVES: To assess the benefits and harms of nutrition support versus no intervention, treatment as usual, or placebo in hospitalised adults at nutritional risk...
May 19, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28524646/cervical-spine-involvement-risk-factors-in-rheumatoid-arthritis-a-meta-analysis
#17
Shuai Zhu, Wangdong Xu, Yubin Luo, Yi Zhao, Yi Liu
AIM: This study aims to discuss risk factors associated with cervical spine involvement (CSI) in patients with rheumatoid arthritis (RA). METHODS: A literature search was performed in Medline, EMBASE, Web of Science and CBMdisc databases for potential studies published before October 2016. The clinical and laboratory data were extracted, and a meta-analysis was performed to evaluate the risk factors for CSI in RA patients. RESULTS: Twelve studies involving a total of 2750 cases with RA and 733 CSI (26...
May 19, 2017: International Journal of Rheumatic Diseases
https://www.readbyqxmd.com/read/28524104/dietary-intake-of-meat-cooking-related-mutagens-hcas-and-risk-of-colorectal-adenoma-and-cancer-a-systematic-review-and-meta-analysis
#18
Manuela Chiavarini, Gaia Bertarelli, Liliana Minelli, Roberto Fabiani
Much evidence suggests that the positive association between meat intake and colorectal adenoma (CRA) and cancer (CRC) risk is mediated by mutagenic compounds generated during cooking at high temperature. A number of epidemiological studies have estimated the effect of meat-related mutagens intake on CRC/CRA risk with contradictory and sometimes inconsistent results. A literature search was carried out (PubMed, Web of Science and Scopus) to identify articles reporting the relationship between the intake of meat-related mutagens (2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP), 2-amino-3,8-dimethylimidazo[4,5-f] quinoxaline (MeIQx), 2-amino-3,4,8-trimethylimidazo[4,5-f] quinoxaline: DiMeIQx, benzo(a) pyrene (B(a)P) and "meat derived mutagenic activity" (MDM)) and CRC/CRA risk...
May 18, 2017: Nutrients
https://www.readbyqxmd.com/read/28524026/-high-flow-nasal-cannulae-oxygen-in-patients-with-respiratory-failure-a-meta-analysis
#19
Weigang Yue, Zhigang Zhang, Caiyun Zhang, Liping Yang, Jufang He, Yuying Hou, Ying Tang, Jinhui Tian
OBJECTIVE: To systematically evaluate the efficacy of high-flow nasal cannulae oxygen (HFNC) in patients with respiratory failure. METHODS: Computerized PubMed, Embase, Web of Science, the Cochrane Library, CNKI, CBM, VIP, Wanfang Database up to March 31st, 2017, all published available randomized controlled trials (RCTs) or cohort studies about HFNC therapy for patients with respiratory failure were searched. The control group was treated with face mask oxygen therapy (FM) or non-invasive positive pressure ventilation (NIPPV), while the experimental group was treated with HFNC...
May 2017: Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
https://www.readbyqxmd.com/read/28522849/carcinopred-el-novel-models-for-predicting-the-carcinogenicity-of-chemicals-using-molecular-fingerprints-and-ensemble-learning-methods
#20
Li Zhang, Haixin Ai, Wen Chen, Zimo Yin, Huan Hu, Junfeng Zhu, Jian Zhao, Qi Zhao, Hongsheng Liu
Carcinogenicity refers to a highly toxic end point of certain chemicals, and has become an important issue in the drug development process. In this study, three novel ensemble classification models, namely Ensemble SVM, Ensemble RF, and Ensemble XGBoost, were developed to predict carcinogenicity of chemicals using seven types of molecular fingerprints and three machine learning methods based on a dataset containing 1003 diverse compounds with rat carcinogenicity. Among these three models, Ensemble XGBoost is found to be the best, giving an average accuracy of 70...
May 18, 2017: Scientific Reports
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