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P2X7 and hyperglycemia

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https://www.readbyqxmd.com/read/29247713/role-of-microglia-neuron-interactions-in-diabetic-encephalopathy
#1
REVIEW
Yuan Liu, Mingchao Li, Zuo Zhang, Yun Ye, Jiyin Zhou
In the central nervous system, the primary immune cells, the microglia, prevent pathogenic invasion as the first line of defense. Microglial energy consumption is dependent on their degree of activity. Microglia express transporters for the three primary energy substrates (glucose, fatty acids, glutamine) and regulate diabetic encephalopathy via microglia-neuron interactions. Microglia may play a sentry role for rapid protection or even ablation of impaired neurons. Neurons exhibit hyperactivity in response to hyperglycemia, hyperlipidemia, and neurotoxic factors and release potential microglial activators...
March 2018: Ageing Research Reviews
https://www.readbyqxmd.com/read/28434946/hyperglycemia-induced-renal-p2x7-receptor-activation-enhances-diabetes-related-injury
#2
Robert I Menzies, John W R Booth, John J Mullins, Matthew A Bailey, Frederick W K Tam, Jill T Norman, Robert J Unwin
Diabetes is a leading cause of renal disease. Glomerular mesangial expansion and fibrosis are hallmarks of diabetic nephropathy and this is thought to be promoted by infiltration of circulating macrophages. Monocyte chemoattractant protein-1 (MCP-1) has been shown to attract macrophages in kidney diseases. P2X7 receptors (P2X7R) are highly expressed on macrophages and are essential components of pro-inflammatory signaling in multiple tissues. Here we show that in diabetic patients, renal P2X7R expression is associated with severe mesangial expansion, impaired glomerular filtration (≤40ml/min/1...
May 2017: EBioMedicine
https://www.readbyqxmd.com/read/25938443/the-atp-receptors-p2x7-and-p2x4-modulate-high-glucose-and-palmitate-induced-inflammatory-responses-in-endothelial-cells
#3
Ramasri Sathanoori, Karl Swärd, Björn Olde, David Erlinge
Endothelial cells lining the blood vessels are principal players in vascular inflammatory responses. Dysregulation of endothelial cell function caused by hyperglycemia, dyslipidemia, and hyperinsulinemia often result in impaired vasoregulation, oxidative stress, inflammation, and altered barrier function. Various stressors including high glucose stimulate the release of nucleotides thus initiating signaling via purinergic receptors. However, purinergic modulation of inflammatory responses in endothelial cells caused by high glucose and palmitate remains unclear...
2015: PloS One
https://www.readbyqxmd.com/read/23523697/high-glucose-impairs-atp-formation-on-the-surface-of-human-peripheral-blood-b-lymphocytes
#4
Monika Sakowicz-Burkiewicz, Marzena Grden, Izabela Maciejewska, Andrzej Szutowicz, Tadeusz Pawelczyk
Diabetes-associated lymphocyte dysfunction may be attributed to the direct effect of hyperglycemia, but the impact of glucose concentration on B cell functionality is not fully resolved. Since, adenosine 5'-triphosphate (ATP) and its metabolite adenosine are the core constituents of the purinergic signaling network involved in regulation of immune response we aimed to investigate the impact of high glucose concentration on ATP outflow and metabolism on B cell surface. Purified human peripheral blood B cells cultured at high glucose (25 mM) concentration released significantly less ATP (~60%) comparing to cells cultured in low glucose (5mM) concentration...
July 2013: International Journal of Biochemistry & Cell Biology
https://www.readbyqxmd.com/read/22883563/high-glucose-concentration-impairs-atp-outflow-and-immunoglobulin-production-by-human-peripheral-b-lymphocytes-involvement-of-p2x7-receptor
#5
Monika Sakowicz-Burkiewicz, Katarzyna Kocbuch, Marzena Grden, Izabela Maciejewska, Andrzej Szutowicz, Tadeusz Pawelczyk
AIMS/HYPOTHESIS: Patients with diabetes are more prone to bacterial infections mostly due to hyperglycemia-induced suppression of immune cells function. B lymphocytes by secreting antibodies inhibit microbial replication, but the impact of high glucose concentration on humoral immune response is not fully resolved. The aim of this work was to investigate the effect of high glucose concentration on B cells response to stimulation with a bacterial antigen and autocrine regulation. METHODS: Purified human peripheral blood B cells were cultured at different glucose concentrations and stimulated in vitro with Staphylococcus aureus Cowan I (SAC) plus IL-2...
April 2013: Immunobiology
https://www.readbyqxmd.com/read/22415881/the-atp-p2x7-signaling-axis-is-dispensable-for-obesity-associated-inflammasome-activation-in-adipose-tissue
#6
Shengyi Sun, Sheng Xia, Yewei Ji, Sander Kersten, Ling Qi
Inflammasome activation in adipose tissue has been implicated in obesity-associated insulin resistance and type 2 diabetes. However, when and how inflammasome is activated in adipose tissue remains speculative. Here we test the hypothesis that extracellular ATP, a potent stimulus of inflammasome in macrophages via purinergic receptor P2X, ligand-gated ion channel, 7 (P2X(7)), may play a role in inflammasome activation in adipose tissue in obesity. Our data show that inflammasome is activated in adipose tissue upon 8-week feeding of 60% high-fat diet (HFD), coinciding with the onset of hyperglycemia and hyperinsulinemia as well as the induction of P2X(7) in adipose tissue...
June 2012: Diabetes
https://www.readbyqxmd.com/read/21832250/purinergic-regulation-of-high-glucose-induced-caspase-1-activation-in-the-rat-retinal-m%C3%A3-ller-cell-line-rmc-1
#7
Katherine E Trueblood, Susanne Mohr, George R Dubyak
Chronic activation of proinflammatory caspase-1 in the retinas of diabetic animals and patients in vivo and retinal Müller cells in vitro is well documented. In this study we characterized how elevated glucose and extracellular purines contribute to the activation of caspase-1 in a cultured rat Müller cell (rMC-1) model. The ability of high glucose (25 mM, 24 h) to activate caspase-1 was attenuated by either apyrase, which metabolizes extracellular ATP to AMP, or adenosine deaminase (ADA), which metabolizes extracellular adenosine to inosine...
November 2011: American Journal of Physiology. Cell Physiology
https://www.readbyqxmd.com/read/18801407/p2rx7-gln460arg-polymorphism-is-associated-with-depression-among-diabetic-patients
#8
Geza Nagy, Zsolt Ronai, Aniko Somogyi, Maria Sasvari-Szekely, Omar Abdul Rahman, Attila Mate, Timea Varga, Zsofia Nemoda
AIMS: Both diabetes mellitus and major depression are public health concerns, and the co-occurrence of these illnesses is highly frequent. Acting as a potential risk factor, hyperglycemia might facilitate the manifestation of depression in patients genetically predisposed to affective disorders. In the present study, candidate polymorphisms of the serotonin transporter, the tryptophan hydroxylase 2 (TPH2) genes, as well as of the brain-derived neurotrophic factor BDNF, and the P2RX7 purinergic receptor genes were analyzed in Hungarian diabetic population...
December 12, 2008: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/14985326/enhancement-of-p2x-7-induced-pore-formation-and-apoptosis-an-early-effect-of-diabetes-on-the-retinal-microvasculature
#9
Tetsuya Sugiyama, Masato Kobayashi, Hajime Kawamura, Qing Li, Donald G Puro, Masato Kobayshi
PURPOSE: A sight-threatening complication of diabetes is cell death in retinal capillaries. Currently, the mechanisms responsible for this classic manifestation of diabetic retinopathy remain uncertain. The hypothesis for the current study is that diabetes increases the vulnerability of retinal microvessels to the potentially lethal consequences of having their P2X(7) purinoceptors activated. A pathophysiological role is suspected for these receptor-operated channels because, in addition to transducing retinovascular responses to extracellular adenosine triphosphate (ATP), the sustained opening of these channels can induce the formation of large transmembrane pores...
March 2004: Investigative Ophthalmology & Visual Science
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