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P2Y4 and hyperglycemia

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https://www.readbyqxmd.com/read/16497986/extracellular-nucleotides-and-adenosine-independently-activate-amp-activated-protein-kinase-in-endothelial-cells-involvement-of-p2-receptors-and-adenosine-transporters
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Cleide Gonçalves da Silva, Robert Jarzyna, Anke Specht, Elzbieta Kaczmarek
AMP-activated protein kinase (AMPK) plays a key role in the regulation of energy homeostasis and is activated in response to cellular stress, including hypoxia/ischemia and hyperglycemia. The stress events are accompanied by rapid release of extracellular nucleotides from damaged tissues or activated endothelial cells (EC) and platelets. We demonstrate that extracellular nucleotides (ATP, ADP, and UTP, but not UDP) and adenosine independently induce phosphorylation and activation of AMPK in human umbilical vein EC (HUVEC) by the mechanism that is not linked to changes in AMP:ATP ratio...
March 17, 2006: Circulation Research
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