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https://www.readbyqxmd.com/read/28743176/technique-of-skeletal-navigation-for-localizing-solitary-pulmonary-nodules
#1
Rui Mao, Weirong Shi, Donglai Chen, Xier Maimaiti Kadeer, Mu Li, Ke Fei, Chang Chen
We herein detail a novel method of skeletal navigation for localizing small solitary pulmonary nodules of 8-30 mm size and at a distance of less than 15 mm from visceral pleura. Thirty-four lesions found in 29 patients were successfully localized. All 34 target nodules first underwent wedge resections, and there were no cases of technical failure of the present method. This technique incurs no additional cost and complications as caused by other localization approaches. Additionally, this approach provides a backup method in cases of mark displacement...
July 25, 2017: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28740682/combined-analgesic-treatment-of-epidural-and-paravertebral-block-after-thoracic-surgery
#2
Yujiro Yokoyama, Takahiro Nakagomi, Daichi Shikata, Taichiro Goto
In pulmonary surgical practice, appropriate pain management after thoracotomy is essential for patient recovery and the prevention of complications. Although epidural analgesia (EPI) has been established for chest surgery, it has some limitations and contraindications. Recently, paravertebral block (PVB) was reported as a good alternative method with fewer side effects. Despite the significant effects of these two treatments, postoperative pain remains among the greatest patient burdens. In our institution, we apply a combination of epidural and PVBs after thoracic surgery to reduce pain more effectively...
June 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/28734445/primary-solitary-fibrous-tumor-of-the-forearm-with-frequent-late-onset-recurrence-in-the-pleura
#3
Yoko Yamamoto, Ryu Kanzaki, Masayoshi Inoue, Meinoshin Okumura
Solitary fibrous tumor (SFT) is a relatively rare form of mesenchymal tumor that generally has a benign clinical course. However, SFTs have malignant potential. We report the case of a 36-year-old man with local relapse and frequent late-onset pleural metastasis of primary SFT of the forearm. Pleural metastasis was first seen 11 years after the initial operation. During a 17-year period, he underwent 5 surgical resections. He has been free of disease for 61 months since the most recent operation.
August 2017: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/28733201/prone-percutaneous-nephrolithotomy-does-bolster-orientation-matter
#4
Daniel Sagalovich, Cecilia Besa, Timothy Tran, Haresh Thummar, Blake Le Grand, Bachir Taouli, Mantu Gupta
OBJECTIVES: To assess whether horizontal versus vertical bolster orientation affects kidney position during prone percutaneous nephrolithotomy as this could impact the need for supracostal access and therefore the likelihood of pleural injury. METHODS: In a prospective trial, ten subjects with 20 renal units underwent magnetic resonance imaging in prone position with standard cylindrical bolsters oriented vertically and then horizontally. Vertical bolsters were placed along the lateral aspect of the chest...
July 18, 2017: Urology
https://www.readbyqxmd.com/read/28730250/metastatic-high-grade-myxofibrosarcoma-review-of-a-clinical-case
#5
Tiberiu Paul Neagu, Ruxandra Diana Sinescu, Valentin Enache, Sanda Claudia Achim, Mirela Ţigliş, Liliana Elena Mirea
We present the particular clinical and histological features of a metastatic high-grade myxofibrosarcoma (MFS) of the left buttock in a 77-year-old male patient. The tumor was biopsied and surgically removed in order to increase the patient's comfort, due to its increased size and aggressive clinical behavior. Computed tomography (CT) revealed metastases in the pleura and mediastinal lymph nodes, so limb-sparing tumor excision followed by palliative care was the best practice for the patient until the fatal outcome...
2017: Romanian Journal of Morphology and Embryology, Revue Roumaine de Morphologie et Embryologie
https://www.readbyqxmd.com/read/28729349/fgf9-prevents-pleural-fibrosis-induced-by-intra-pleural-adenovirus-injection-in-mice
#6
Aurélien Justet, Audrey Joannes, Valérie Besnard, Joëlle Marchal-Sommé, Madeleine Jaillet, Phillippe Bonniaud, Jean-Michel Sallenave, Brigitte Solhonne, Yves Castier, Pierre Mordant, Hervé Mal, Aurélie Cazes, Raphael Borie, Arnaud A Mailleux, Bruno Crestani
Fibroblast Growth Factor 9 (FGF9) is necessary for fetal lung development and is expressed by epithelium and mesothelium. We evaluated the role of FGF9 overexpression on adenoviral-induced pleural injury in vivo and determined the biological effects of FGF9 on mesothelial cells in vitro. We assessed the expression of FGF9 and FGF receptors by mesothelial cells in both Human and mouse lungs. Intrapleural injection of an adenovirus expressing human FGF9 (AdFGF9) or a control adenovirus (Adcont) was performed...
July 20, 2017: American Journal of Physiology. Lung Cellular and Molecular Physiology
https://www.readbyqxmd.com/read/28726658/-optimization-of-diagnostics-of-exudative-pleuritis-of-unknown-origin
#7
B Bayramov
The article describes 143 cases of exudative pleuritis of unknown origin in patients who were diagnosed and treated with any minimally invasive surgical procedures: pleural puncture (PP), video-assisted thoracoscopy (VATS) with biopsy of the pleura. A different diagnostic methods (cytological, microbiological, histological) used in various diagnostic surgical procedures are analyzed in detail and calculated diagnostic sensitivity, specificity, and accuracy of each method. Based on the analysis of cytological, histological and microbiological studies in the performance of VATS concluded relatively high, comparable with the method of open pleural biopsy, diagnostic efficiency, the sensitivity of this method in the scheme of the diagnostic algorithm of EP of unknown origin...
June 2017: Georgian Medical News
https://www.readbyqxmd.com/read/28718312/gbm-skin-metastasis-a-case-report-and-review-of-the-literature
#8
Gary D Lewis, Andreana L Rivera, Ivo W Tremont-Lukats, Leomar Y Ballester-Fuentes, Yi Jonathan Zhang, Bin S Teh
Glioblastoma (GBM) is the most common type of malignant tumor found in the brain, and acts very aggressively by quickly and diffusely infiltrating the surrounding brain parenchyma. Despite its aggressive nature, GBM is rarely found to spread extracranially and develop distant metastases. The most common sites of these rare metastases are the lungs, pleura and cervical lymph nodes. There are also a few case reports of skin metastasis. We present the clinical, imaging and pathologic features of a case of a GBM with metastasis to the soft tissue scar and skin near the original craniotomy site...
July 18, 2017: CNS Oncology
https://www.readbyqxmd.com/read/28717083/pirfenidone-induced-eosinophilic-pleurisy
#9
Isano Hase, Bunpei Yamaguchi, Hidenori Takizawa, Hiroaki Arakawa, Hideo Sakuma, Koichi Fujiu, Hideaki Miyamoto, Yoshiki Ishii
The patient was a 69-year-old man with idiopathic pulmonary fibrosis who was taking pirfenidone. After 7 weeks of treatment, he suffered from left-sided eosinophilic pleurisy. Medical thoracoscopy was performed and the histopathological examination of the parietal pleura revealed the massive infiltration of eosinophils and lymphoid follicles. After stopping pirfenidone therapy, the patient's pleural effusion disappeared without additional treatment, and never recurred. This is the first case report of pirfenidone-induced pleurisy...
2017: Internal Medicine
https://www.readbyqxmd.com/read/28716868/solitary-fibrous-tumour-a-rare-tumour-of-the-pleural-cavity
#10
Ronit Bar-Haim, Alexe Gavrilov, Alexander Samokhvalov, Edward Altman
Solitary fibrous tumours are a rare group of tumours that originate from connective tissues such as the pleura and mediastinum. When growing within the thoracic cavity these tumours exert pressure on vital organs and large vessels. We have successfully operated on two patients with large solitary fibrous tumours and managed the pathophysiological changes manifested as superior vena cava syndrome resulting from these tumours.
July 16, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28716200/benchmarking-of-pluck-lesions-at-slaughter-as-a-health-monitoring-tool-for-pigs-slaughtered-at-170kg-heavy-pigs
#11
Annalisa Scollo, Flaviana Gottardo, Barbara Contiero, Claudio Mazzoni, Philippe Leneveu, Sandra A Edwards
Abattoir post-mortem inspections offer a useful tool for the development and monitoring of animal health plans and a source of data for epidemiological investigation. The aim of the present work was to develop an abattoir benchmarking system which provides feedback on the prevalence and severity of lesions of the pluck (lung, pleura and liver) in batches of pigs to inform individual producers and their veterinarians of the occurrence of pathological conditions affecting their herds. The weekly collection of data throughout a year (from September 2014 to September 2015) supported the further aim of providing benchmark values for the prevalence of lesions and their seasonality in Italian heavy pig production...
September 1, 2017: Preventive Veterinary Medicine
https://www.readbyqxmd.com/read/28714265/can-malignant-and-inflammatory-pleural-effusions-in-dogs-be-distinguished-using-computed-tomography
#12
Thom C Watton, Ana Lara-Garcia, Christopher R Lamb
Computed tomography (CT) is the primary imaging modality used to investigate human patients with suspected malignant or inflammatory pleural effusion, but there is a lack of information about the clinical use of this test in dogs. To identify CT signs that could be used to distinguish pleural malignant neoplasia from pleuritis, a retrospective case-control study was done based on dogs that had pleural effusion, pre- and postcontrast thoracic CT images, and cytological or histopathological diagnosis of malignant or inflammatory pleural effusion...
July 16, 2017: Veterinary Radiology & Ultrasound
https://www.readbyqxmd.com/read/28713675/novel-systemic-therapy-against-malignant-pleural-mesothelioma
#13
REVIEW
Michael R Mancuso, Joel W Neal
Malignant pleural mesothelioma is an aggressive tumor of the pleura with an overall poor prognosis. Even with surgical resection, for which only a subset of patients are eligible, long term disease free survival is rare. Standard first-line systemic treatment consists of a platinum analog, an anti-metabolite, and sometimes anti-angiogenic therapy, but there is currently no well-established standard therapy for refractory or relapsed disease. This review focuses on efforts to develop improved systemic therapy for the treatment of malignant pleural mesothelioma (MPM) including cytotoxic systemic therapy, a variety of tyrosine kinase inhibitors and their downstream effector pathways, pharmacologic targeting of the epigenome, novel approaches to target proteins expressed on mesothelioma cells (such as mesothelin), arginine depletion therapy, and the emerging role of immunotherapy...
June 2017: Translational Lung Cancer Research
https://www.readbyqxmd.com/read/28710703/igg4-related-disease-involving-polyserous-effusions-with-elevated-serum-interleukin-6-levels-a-case-report-and-literature-review
#14
Xiang Tong, Min Bai, Weiya Wang, Qingbing Han, Panwen Tian, Hong Fan
Immunoglobulin G4-related disease (IgG4-RD) is a recently described immune-mediated fibroinflammatory disease with a characteristic histopathologic appearance that can affect various organs. We report a 43-year-old Chinese female patient with IgG4-RD involving polyserous effusions with reports of worsening exertional dyspnea for 3 months. Laboratory blood tests revealed that serum interleukin (IL)-6, carbohydrate antigens (CA-199 and CA-125), and alpha-fetoprotein levels were significantly increased, but serum IgG4 levels were normal...
July 14, 2017: Immunologic Research
https://www.readbyqxmd.com/read/28709816/-current-knowledge-on-perioperative-treatments-of-non-small-cell-lung-carcinomas
#15
REVIEW
S Brosseau, C Naltet, M Nguenang, V Gounant, P Mordant, B Milleron, Y Castier, G Zalcman
Surgery is still the main treatment in early-stage of non-small cell lung cancer with 5-year survival of stage IA patients exceeding 80%, but 5-year survival of stage II patients rapidly decreasing with tumor size, N status, and visceral pleura invasion. The major metastatic risk in such patients has supported clinical research assessing systemic or loco-regional perioperative treatments. Modern phase 3 trials clearly validated adjuvant or neo-adjuvant platinum-based chemotherapy in resected stage I-III patients as a standard treatment of which value has been reassessed several independent meta-analyses, showing a 5% benefit in 5y-survival, and a decrease of the relative risk for death around from 12 to 25%...
July 11, 2017: Revue des Maladies Respiratoires
https://www.readbyqxmd.com/read/28707542/the-physiological-consequences-of-different-distributions-of-diffuse-pleural-thickening-on-ct-imaging
#16
Duneesha de Fonseka, Anthony Edey, Louise Stadon, Jason Viner, Michael Darby, Nick A Maskell
OBJECTIVES: Diffuse pleural thickening refers to extensive visceral pleural fibrosis, with adhesion formation to the parietal pleura, obliterating the pleural space. The radiological definition of DPT remains controversial with most literature requiring the presence of an obliterated costophrenic angle for defining DPT. We conducted a study to investigate the variable distributions of DPT and associated lung function deficit. METHODS: Eighty-five patients referred to a pleural clinic with suspected pleural thickening were screened for our study...
July 14, 2017: British Journal of Radiology
https://www.readbyqxmd.com/read/28706914/pleurectomy-and-decortication
#17
Tedi Vlahu, Wicki T Vigneswaran
Pleurectomy and decortication (P/D) improve survival and quality of life in selected patients with malignant pleural mesothelioma. The operative procedure was not standardized until recently. The goal of the operation is to perform a macroscopic complete resection of the tumor. This often involves resection of the parietal and visceral pleura and invariably a partial or complete resection and prosthetic reconstruction of ipsilateral hemidiaphragm. We describe our operative planning and technique as well as outcomes of P/D reported in current literature...
June 2017: Annals of Translational Medicine
https://www.readbyqxmd.com/read/28706913/novel-immunotherapy-clinical-trials-in-malignant-pleural-mesothelioma
#18
Zachary E Tano, Navin K Chintala, Xiaoyu Li, Prasad S Adusumilli
In this article, we review ongoing novel clinical trials currently investigating immunotherapeutic approaches for patients with malignant pleural mesothelioma (MPM). There is a dearth of effective therapeutic options for patients diagnosed with MPM and metastatic cancers of the pleura; these diseases have an estimated annual incidence of 150,000. Modulating the immune microenvironment to promote antitumor immune responses by systemically and regionally delivered therapeutic agents is an active area of investigation...
June 2017: Annals of Translational Medicine
https://www.readbyqxmd.com/read/28706904/malignant-peritoneal-mesothelioma-a-review
#19
REVIEW
Joseph Kim, Shanel Bhagwandin, Daniel M Labow
Mesothelioma is a malignancy of serosal membranes. It is most commonly encountered in the visceral pleura with the second most common location in the peritoneum. The diagnosis is very rare and has been linked to toxic exposure to industrial pollutants, especially asbestos. Malignant peritoneal mesothelioma (MPM) commonly presents with diffuse, extensive spread throughout the abdomen with rare metastatic spread beyond the abdominal cavity. Due to its rarity and nonspecific symptoms, it is usually diagnosed late when the disease burden is extensive...
June 2017: Annals of Translational Medicine
https://www.readbyqxmd.com/read/28706903/overview-of-treatment-related-complications-in-malignant-pleural-mesothelioma
#20
REVIEW
David J Murphy, Ritu R Gill
Malignant pleural mesothelioma (MPM) is an aggressive malignant neoplasm of the pleura related to asbestos exposure. Despite recent advances in therapy for MPM, the prognosis remains poor, with considerable treatment associated morbidity. Radiological assessment plays a central role in the timely identification and subsequent management of treatment related complications in MPM. This review highlights common and uncommon complications associated with and encountered in the post treatment phase.
June 2017: Annals of Translational Medicine
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