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https://www.readbyqxmd.com/read/28644685/application-of-immunohistochemistry-in-the-diagnosis-of-pulmonary-and-pleural-neoplasms
#1
Jennifer S Woo, Opal L Reddy, Matthew Koo, Yan Xiong, Faqian Li, Haodong Xu
CONTEXT: - A vast majority of neoplasms arising from lung or pleura are initially diagnosed based on the histologic evaluation of small transbronchial, endobronchial, or needle core biopsies. Although most diagnoses can be determined by morphology alone, immunohistochemistry can be a valuable diagnostic tool in the workup of problematic cases. OBJECTIVE: - To provide a practical approach in the interpretation and immunohistochemical selection of lung/pleura-based neoplasms obtained from small biopsy samples...
June 23, 2017: Archives of Pathology & Laboratory Medicine
https://www.readbyqxmd.com/read/28643792/smarca4-deficient-thoracic-sarcoma-a-distinctive-clinicopathological-entity-with-undifferentiated-rhabdoid-morphology-and-aggressive-behavior
#2
Jennifer L Sauter, Rondell P Graham, Brandon T Larsen, Sarah M Jenkins, Anja C Roden, Jennifer M Boland
A distinct subset of thoracic sarcomas with undifferentiated rhabdoid morphology and SMARCA4 inactivation has recently been described, and potential targeted therapy for SMARC-deficient tumors is emerging. We sought to validate the clinicopathological features of SMARCA4-deficient thoracic sarcomas. Clinicopathological information was gathered for 40 undifferentiated thoracic tumors with rhabdoid morphology (mediastinum (n=18), lung (n=14), pleura (n=8)). Thymic carcinomas (n=11) were used as a comparison group...
June 23, 2017: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
https://www.readbyqxmd.com/read/28643111/thymic-carcinoma-initially-presented-with-geographic-destruction-of-scapula-in-a-child
#3
Won-Jong Bahk, An-Hi Lee, Eun-Deok Chang, Dong-Wook Min, Yong-Koo Kang
As the conventional histopathologic examination of thymic carcinoma (TC) is nonspecific, immunohistochemical studies along with correlative radiographic investigations are needed for its correct diagnosis. TC commonly occurs in the late 5th to early 6th decades of life but is extremely rare in childhood. It may be incidentally detected from chest radiographs taken as routine or for other reasons. However, most patients present with symptoms such as chest pain, cough, shortness of breath, dysphagia and hoarseness, which are directly attributable to the mediastinal mass...
June 23, 2017: Skeletal Radiology
https://www.readbyqxmd.com/read/28639833/predictive-ct-features-of-visceral-pleural-invasion-by-t1-sized-peripheral-pulmonary-adenocarcinomas-manifesting-as-subsolid-nodules
#4
Su Yeon Ahn, Chang Min Park, Yoon Kyung Jeon, Hyungjin Kim, Jong Hyuk Lee, Eui Jin Hwang, Jin Mo Goo
OBJECTIVE: The objective of our study was to determine whether visceral pleural invasion (VPI) of T1-sized peripheral pulmonary adenocarcinomas manifesting as subsolid nodules (SSNs) abutting the pleural surface or associated with pleural tags can be predicted. MATERIALS AND METHODS: Our study population consisted of 188 T1-sized peripheral pulmonary adenocarcinomas that appeared as SSNs (24 pure ground-glass nodules [GGNs] and 164 part-solid nodules) and underwent surgical resection between January 2007 and December 2013...
June 22, 2017: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/28638296/ultrasound-guided-percutaneous-cervical-and-upper-thoracic-sympathetic-chain-neuromodulation-for-upper-extremity-complex-regional-pain-syndrome
#5
Samer Narouze, Dmitri Souzdalnitski
BACKGROUND: Complex regional pain syndrome (CRPS) comprises a group of conditions characterized by severe, debilitating pain that is disproportionate to any inciting event and is not distributed in a specific nerve distribution or dermatome. CASE REPORT: A 42-year-old female with a 2-year history of right upper extremity CRPS type I refractory to conventional management underwent an ultrasound-guided and fluoroscopy confirmed percutaneous peripheral nerve stimulation trial with a lead extending from the C6 to the T3 level to cover the cervical and upper thoracic sympathetic chain...
2017: Ochsner Journal
https://www.readbyqxmd.com/read/28634559/malignant-pleural-mesothelioma-with-marked-lymphatic-involvement-a-report-of-two-autopsy-cases
#6
Reiko Ideguchi, Kazuto Ashizawa, Saori Akashi, Michiko Shindo, Kazunori Minami, Toshio Fukuda, Junji Irie, Minoru Fukuda, Masataka Uetani
We herein report two cases of malignant pleural mesothelioma with marked lymphangiosis. The patients included a 68-year-old man and a 67-year-old man who both had a history of exposure to asbestos. Computed tomography (CT) on admission showed pleural effusion with pleural thickening. In both cases, a histopathological examination of the pleura confirmed the diagnosis of epithelioid malignant mesothelioma. They received chemotherapy, but the treatment was only palliative. The chest CT assessments during admission revealed marked pleural effusion and mediastinal lymphadenopathy...
2017: Case Reports in Oncological Medicine
https://www.readbyqxmd.com/read/28633728/bilateral-large-pneumothoraxes-following-implantable-cardioverter-defibrillator-generator-change-a-case-report-of-an-uncommon-event-complicating-a-common-procedure
#7
Ritin Bomb, Sunil K Jha
INTRODUCTION: A bilateral large spontaneous pneumothorax to our knowledge has never been reported after a device implantation. We report an unusual case of a patient developing spontaneous bilateral large pneumothoraxes after an implantable cardioverter-defibrillator generator and lead revision without evidence of any obvious traumatic cardiac injury. CASE PRESENTATION: A 79-year-old white man was scheduled for implantable cardioverter-defibrillator generator change and addition of an atrial lead...
2017: Permanente Journal
https://www.readbyqxmd.com/read/28625620/prognostic-impact-of-uncertain-parietal-pleural-invasion-at-adhesion-sites-in-non-small-cell-lung-cancer-patients
#8
Masashi Mikubo, Hiroyasu Nakashima, Masahito Naito, Yoshio Matsui, Kazu Shiomi, Shi-Xu Jiang, Yukitoshi Satoh
OBJECTIVES: Pleural invasion has been recognized as an important negative prognostic factor in non-small cell lung cancer (NSCLC), and therefore, accurate evaluation is required. However, when the visceral pleura adheres to the parietal pleura around a tumor and parietal pleural structures are destroyed and unrecognizable as a result of inflammation, it is often difficult to accurately evaluate pleural invasion, and classification of the T stage is unclear. To aid in categorization, we defined this status as pl1-3 and investigated the prognostic impact of the pl1-3 status on NSCLC...
June 2017: Lung Cancer: Journal of the International Association for the Study of Lung Cancer
https://www.readbyqxmd.com/read/28624061/new-noncontact-sensor-for-detecting-pulmonary-tumors-during-video-assisted-thoracic-surgery
#9
Koichi Akayama, Yoshihiro Miyata, Tomohiro Kawahara, Morihito Okada, Makoto Kaneko, Masazumi Okajima, Hideki Ohdan
BACKGROUND: Small pulmonary tumors are difficult to localize during video-assisted thoracic surgery (VATS) because of lack of direct tissue contact. However, in partial lung resection, tumor localization is quite important. The aim of this study was to evaluate the safety and feasibility of a new noncontact sensor for detecting pulmonary nodules during VATS using human and porcine models. METHODS: The sensor, based on the principle of phase differences, comprises an air nozzle for producing air pulse jets and an optical fiber sensor to measure phase differences and visualize object stiffness...
June 15, 2017: Journal of Surgical Research
https://www.readbyqxmd.com/read/28621469/solitary-fibrous-tumor-of-the-breast-a-case-report-and-the-review-of-the-literature
#10
Nikolaos S Salemis
Solitary fibrous tumors (SFT) are rare mesenchymal neoplasms. They were first described as spindle-cell tumors originating from the pleura, but they may arise in any anatomical site. SFT of the breast is an exceedingly rare clinical entity. Our literature review yielded only 21 cases reported so far. We describe a case of a SFT of the breast in a premenopausal patient who presented with a gradually enlarging palpable breast mass. Diagnostic evaluation and management are discussed along with a review of the relevant literature...
June 16, 2017: Breast Journal
https://www.readbyqxmd.com/read/28620563/pharmacological-threat-to-lungs-a-case-series-and-literature-review
#11
REVIEW
Omar Irfan, Jaleed A Gilani, Abeel Irshad, Babar Irfan, Javaid A Khan
Drug-induced organ damage stands as a prevalent yet much-neglected issue globally. Keeping in view it's rising frequency, health care providers stand obliged to be well versed with the de-merits of the agents they prescribe. Drug therapies causing damage present with a non-specific clinical presentation, histological findings or radiology, which further elaborates on the necessity of a conscientious diagnosis. Pulmonary architecture ranging from the airways, lung parenchyma, mediastinum, pleura, pulmonary vasculature or the neuromuscular system, all can fall victim to the dreaded outcomes of this menace...
May 9, 2017: Curēus
https://www.readbyqxmd.com/read/28617941/association-of-igg4-and-free-light-chain-with-idiopathic-pleural-effusion
#12
Yoriyuki Murata, Keisuke Aoe, Yuka Mimura-Kimura, Tomoyuki Murakami, Keiji Oishi, Tsuneo Matsumoto, Hiroshi Ueoka, Kazuto Matsunaga, Masafumi Yano, Yusuke Mimura
The cause of pleural effusion remains uncertain in approximately 15% of patients despite exhaustive evaluation. As recently described IgG4-related disease is a fibroinflammatory disorder that can affect various organs including the lungs, we investigate whether idiopathic pleural effusion includes IgG4-associated etiology. Between 2000 and 2012, we collected 830 pleural fluid samples and reviewed 35 patients with pleural effusions undiagnosed after pleural biopsy at Yamaguchi-Ube Medical Center. Importantly, IgG4 immunostaining revealed infiltration of IgG4-positive plasma cells in the pleura of 12 patients (34%, IgG4+ group)...
June 15, 2017: Clinical and Experimental Immunology
https://www.readbyqxmd.com/read/28616293/video-assisted-thoracoscopic-completion-thymectomy-based-on-mediastinal-pleura-guidance
#13
Kai Guo, Liping Tong, Xiaofei Li, Xiaolong Yan
We describe a practical video-assisted thoracoscopic surgery (VATS) technique for the en bloc resection of the thymoma, thymus, and bilateral mediastinum lipid based on mediastinal pleura guidance. By taking advantage of single-lumen endotracheal tube (SLET) anesthesia and artificial pneumothorax, we acquired excellent exposure of the anterior mediastinum operative field. In addition, our limited data showed that this surgical approach might have a potential tendency on reducing the blood loss and the operative times...
May 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/28616274/remedial-localization-after-dislodgement-of-primary-mechanical-localization-in-lung-surgery
#14
Long Wang, Xufeng Zhang, Mu Li, Xiermaimaiti Kadeer, Chenyang Dai, Zhe Shi, Chang Chen
BACKGROUND: Unhooking or displacement of hookwire or microcoil due to technical failures is rather common. We aim to establish a new technique for remedial localization in the case of displacement or unhooking of primary mechanical localization during lung surgery. METHODS: From February 2014 to September 2015, 18 consecutive cases of intraoperative dislodgement during video-assisted thoracoscopic surgery (VATS) were enrolled. Nodule's projection on body surface was located by analyzing computed tomography (CT) images, and a needle was inserted into thoracic cavity through this point...
May 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/28614203/gata3-immunohistochemistry-for-distinguishing-sarcomatoid-and-desmoplastic-mesothelioma-from-sarcomatoid-carcinoma-of-the-lung
#15
Kyra B Berg, Andrew Churg
The separation of sarcomatoid and desmoplastic malignant mesotheliomas from sarcomatoid carcinomas of the lung metastatic to the pleura may be difficult, since both types of tumor can be morphologically similar and are frequently positive only for pan-keratin. GATA binding protein 3 (GATA3) is most commonly used as an immunohistochemical marker of breast and urothelial carcinoma, but is also known to stain other types of tumors including some mesotheliomas. In this study we asked whether GATA3 stains could be used to distinguish sarcomatoid/desmoplastic malignant mesotheliomas (N=19) from sarcomatoid carcinomas of the lung (N=13)...
June 13, 2017: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/28609931/a-new-subfamily-of-feaellidae-arachnida-chelonethi-feaelloidea-from-southeast-asia
#16
Mark L I Judson
The first extant representatives of the pseudoscorpion family Feaellidae from Southeast Asia are described. Cybella n. gen. is proposed for Cybella deharvengi n. sp. (type species), collected from an isolated limestone hill in Hon Chong Province, Vietnam, and C. bedosae n. sp., found in a limestone cave in Kampuchea, Cambodia. Cybella species seem to be restricted to karst formations and are probably troglophilic. The type localities of the two known species are threatened by quarrying activities, these being particularly pressing in the case of C...
April 26, 2017: Zootaxa
https://www.readbyqxmd.com/read/28604085/tension-pneumothorax-after-percutaneous-tracheostomy
#17
Sarina Matsumura, Naotaka Kishimoto, Tomio Iseki, Yoshihiro Momota
A 76-year-old woman with right mandibular gingival cancer was scheduled for surgery. A percutaneous tracheostomy kit was used for tracheostomy under intravenous sedation. After puncturing the cricothyroid membrane, a dilator was inserted along a guidewire. Bucking was observed at the time of insertion of the dilator, despite intratracheal lidocaine spray applied before insertion. After that, the tracheostomy tube was inserted, but no capnographic waveforms appeared when the tube was connected to the anesthesia circuit...
2017: Anesthesia Progress
https://www.readbyqxmd.com/read/28600498/deregulation-of-mirnas-in-malignant-pleural-mesothelioma-is-associated-with-prognosis-and-suggests-an-alteration-of-cell-metabolism
#18
Chiara De Santi, Ombretta Melaiu, Alessandra Bonotti, Luciano Cascione, Gianpiero Di Leva, Rudy Foddis, Alfonso Cristaudo, Marco Lucchi, Marco Mora, Anna Truini, Andrea Tironi, Bruno Murer, Renzo Boldorini, Monica Cipollini, Federica Gemignani, Pierluigi Gasparini, Luciano Mutti, Stefano Landi
Malignant pleural mesothelioma (MPM) is an aggressive human cancer and miRNAs can play a key role for this disease. In order to broaden the knowledge in this field, the miRNA expression was investigated in a large series of MPM to discover new pathways helpful in diagnosis, prognosis and therapy. We employed nanoString nCounter system for miRNA profiling on 105 MPM samples and 10 healthy pleura. The analysis was followed by the validation of the most significantly deregulated miRNAs by RT-qPCR in an independent sample set...
June 9, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28598780/the-liver-in-familial-mediterranean-fever-is-it-involved
#19
REVIEW
Eldad Ben-Chetrit, Hasan Yazici
OBJECTIVES: Familial Mediterranean fever (FMF) is characterised by recurrent attacks of fever and serositis. It may affect the peritoneum, pleura, synovia and the skin. Usually the liver is intact in FMF. Recently, this concept was challenged by some groups which claimed that hepatitis is a feature of FMF and that non-alcoholic liver disease (NAFLD) and cryptogenic cirrhosis are more common among FMF patients. Scope of this paper is to critically review the relevant literature and to answer the question whether or not the liver is involved in FMF...
June 9, 2017: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/28595233/-solitary-fibrous-tumor-originating-from-the-visceral-pleura-presenting-an-extrapleural-sign-report-of-a-case
#20
Kyosuke Matsunaga, Yusuke Takanashi, Shogo Tajima, Takamitsu Hayakawa, Hiroshi Neyatani
We report a case of solitary fibrous tumor (SFT) originating from the visceral pleura, which presented an extrapleural sign on chest computed tomography (CT) and magnetic resonance imaging (MRI). A 44-year-old woman presented at our hospital for a growing mass visible in chest X-rays. Chest CT and MRI detected a 27×12 mm lesion on the intrathoracic side of the right 3rd intercostal space. The extrapleural signs strongly suggested the tumor to be chest wall origin. However, the tumor was found to be pedunculate with an umbrella-like appearance locating on the visceral pleura of the lung...
June 2017: Kyobu Geka. the Japanese Journal of Thoracic Surgery
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