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https://www.readbyqxmd.com/read/30224623/-a-case-of-carcinoma-showing-thymus-like-differentiation-castle-of-the-thyroid
#1
Yuzuru Inoue, Shiro Kohi, Masato Gobara, Fumi Joden, Kei Yabuki, Takayuki Tanoue, Nagahiro Sato, Takefumi Katsuki, Takahisa Nagata, Kazunori Shibao, Masanori Hisaoka, Keiji Hirata
The case presented herein was a 70-year-old woman who had no compliant, but had a mass in the lower part of the right lobe of the thyroid detected by ultrasound (US). The US image of the tumor, measuring 13 mm in diameter, showed a low and heterogeneous internal echo level with calcification and an irregular margin. The tumor appeared to extend to the adjacent sternothyroid muscle, and cervical lymph node swelling was detected in a computer tomography (CT) image, but no metastatic lesion was found by positron emission tomography (PET)-CT...
2018: Journal of UOEH
https://www.readbyqxmd.com/read/30217623/thymic-epithelial-neoplasms-with-rhabdomyomatous-component-a-clinicopathological-and-immunohistochemical-study-of-7-cases
#2
Neda Kalhor, Cesar A Moran
Seven primary thymic epithelial neoplasms, three thymomas, and four thymic carcinomas with rhabdomyomatous component are herein described. The patients are two women and 5 men between the ages of 42 and 62years (average: 52years). Clinically, the patients presented with non-specific symptoms of cough, chest pain, and dyspnea. None of the patients had history of myasthenia gravis or of previous malignancy. Diagnostic imaging revealed the presence of an anterior mediastinal mass in all the patients. Surgical resection was accomplished in all the cases...
September 11, 2018: Human Pathology
https://www.readbyqxmd.com/read/30037371/-correlation-between-serum-cytokeratin-19-fragment-and-the-clinicopathological-features-and-prognosis-of-thymic-epithelial-tumors
#3
Xuefei Zhang, Chunyu Ji, Zhitao Gu, Wentao Fang
BACKGROUND: So far there's no tumor maker applied in diagnosis and treatment of thymic epithelial tumors. This study is to assess the correlation between serum cytokine 19 fragment (Cyfra 21-1) and clinicopathological features and prognosis of thymic epithelial tumors (TETs). METHODS: The clinical data of 159 patients with TETs in Shanghai Chest Hospital was retrospectively analysed. Patients were divided into groups according to different tumor stages and histotypes...
July 20, 2018: Zhongguo Fei Ai za Zhi, Chinese Journal of Lung Cancer
https://www.readbyqxmd.com/read/29975245/poorly-differentiated-nonkeratinizing-squamous-cell-carcinoma-of-the-thymus-clinicopathologic-and-molecular-genetic-study-of-25-cases
#4
David Suster, German Pihan, Alexander C Mackinnon, Saul Suster
Thymic carcinoma represents a rare and poorly understood type of thymic epithelial neoplasm that has been the subject of much controversy. Poorly differentiated nonkeratinizing squamous cell carcinoma, also known as lymphoepithelioma-like thymic carcinoma, is a rare variant of thymic carcinoma that has not been adequately characterized in the literature. The clinicopathologic, immunohistochemical, ultrastructural, and molecular features of 25 cases are reported. The patients were 19 men and 6 women, ranging in age from 20 to 85 years (mean: 60 y)...
September 2018: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/29803383/useful-computed-tomography-features-for-differentiating-between-focal-atelectasis-and-pleural-dissemination-on-preoperative-evaluations-of-thymic-epithelial-tumors
#5
Shingo Omata, Yoshiyuki Ozawa, Motoo Nakagawa, Masaki Hara, Yuta Shibamoto
PURPOSE: Distinguishing between focal atelectasis (FA) and pleural dissemination (PD) is important for determining the optimal therapeutic strategy for thymic epithelial tumors (TET). This study aimed to identify useful computed tomography (CT) features for distinguishing between these two conditions. MATERIALS AND METHODS: We retrospectively analyzed preoperative CT images of 27 TET, which included 40 PD and 40 FA lesions. Two radiologists independently interpreted the pleural lesions without knowing the final diagnosis...
June 2018: European Journal of Radiology
https://www.readbyqxmd.com/read/29613961/mr-imaging-of-thymic-epithelial-neoplasms
#6
REVIEW
Brett W Carter, John P Lichtenberger, Marcelo F Benveniste
Thymic epithelial neoplasms are malignant lesions that originate from the thymus and include thymoma, thymic carcinoma, and thymic neuroendocrine tumors. Although computed tomography (CT) is typically considered the imaging modality of choice for identifying thymic tumors, characterizing the primary neoplasm, and staging of disease, the role of magnetic resonance (MR) imaging continues to expand. MR imaging is effective in distinguishing thymic epithelial neoplasms and other malignant tumors from benign lesions in the prevascular mediastinum, can be used to characterize and stage thymic tumors in those patients with contraindications to contrast-enhanced CT, and can reveal morphologic features of thymic tumors...
April 2018: Topics in Magnetic Resonance Imaging: TMRI
https://www.readbyqxmd.com/read/29395795/comparison-of-interobserver-agreement-and-diagnostic-accuracy-for-iaslc-itmig-thymic-epithelial-tumor-staging-among-co-registered-fdg-pet-mri-whole-body-mri-integrated-fdg-pet-ct-and-conventional-imaging-examination-with-and-without-contrast-media-administrations
#7
Yoshiharu Ohno, Yuji Kishida, Shinichiro Seki, Hisanobu Koyama, Masao Yui, Kota Aoyagi, Takeshi Yoshikawa
RATIONALE AND OBJECTIVES: The purpose of this study was to compare the interobserver agreements and diagnostic accuracies for IASLC/ITMIG (International Association for the Study of Lung Cancer/International Thymic Malignancies Interest Group) thymic epithelial tumor staging of co-registered fluorodeoxyglucose positron emission tomography/magnetic resonance imaging (FDG-PET/MRI), MRI, integrated fluorodeoxyglucose positron emission tomography/computed tomography (FDG-PET/CT), and conventional imaging examination...
January 22, 2018: Academic Radiology
https://www.readbyqxmd.com/read/29339175/primary-thymic-adenocarcinomas-a-clinicopathological-and-immunohistochemical-study-of-16-cases-with-emphasis-on-the-morphological-spectrum-of-differentiation
#8
Neda Kalhor, Cesar A Moran
Sixteen cases of primary thymic adenocarcinoma are presented. The patients are 9 men and 7 women between the ages of 22 and 68 years (average, 45 years) who presented with non-specific symptoms including cough, chest pain, and dyspnea. Diagnostic imaging revealed the presence of an anterior mediastinal mass, which was surgically removed in all of the patients. Histologically, none of the tumors was encapsulated and showed different growth patterns including mucinous, non-mucinous, and papillary features. The majority of cases showed mixed growth pattern, and the tumor was limited to the mediastinum with only a few cases extending to lymph nodes or pericardium...
April 2018: Human Pathology
https://www.readbyqxmd.com/read/29301178/epidural-metastasis-in-malignant-thymoma-mimicking-epidural-abscess-case-report-and-literature-review
#9
Ji Yoon Kim, Young Seok Lee, Dong Ho Kang, Min Hye Kim, Jeong Hee Lee, Chul Hee Lee, In Sung Park
Thymoma and thymic carcinoma are rare epithelial tumors that originate from the thymus gland. Extrathoracic metastases occur in the liver, kidney, and bone in 1% to 15% of patients. Although thymoma and thymic carcinoma exhibit highly aggressive biological behavior, spinal metastasis is rare. We describe a 78-year-old man with left wrist and grasp weakness that occurred 7 days before admission. The patient underwent thymoma surgery 7 years ago and was cured. Magnetic resonance images showed a rim-enhanced mass in the C6-7-T1 epidural space...
December 2017: Korean Journal of Spine
https://www.readbyqxmd.com/read/29219888/computed-tomography-features-associated-with-the-eighth-edition-tnm-stage-classification-for-thymic-epithelial-tumors
#10
Sukhmani K Padda, Donato Terrone, Lu Tian, Amanda Khuong, Joel W Neal, Jonathan W Riess, Mark F Berry, Chuong D Hoang, Bryan M Burt, Ann N Leung, Erich J Schwartz, Joseph B Shrager, Heather A Wakelee
PURPOSE: The eighth edition of the TNM classification of malignant tumors for the first time includes an official staging system for thymic epithelial tumors (TETs) recognized by the American Joint Committee on Cancer (AJCC) and the Union for International Cancer Control (UICC). Staging is critical for the management of TETs, and determining stage accurately from imaging has the potential to improve clinical outcomes. We examine preoperative computed tomography (CT) characteristics of TETs associated with AJCC/UICC pathologic TNM stage...
May 2018: Journal of Thoracic Imaging
https://www.readbyqxmd.com/read/29114474/thymic-epithelial-tumors-and-metastasis-to-the-brain-a-case-series-and-systematic-review
#11
Helen Gharwan, Chul Kim, Anish Thomas, Arlene Berman, Sun A Kim, Nadia Biassou, Seth M Steinberg, Arun Rajan
Background: Thymic epithelial tumors (TETs) rarely metastasize to the brain. Clinico-pathologic features of TET patients with brain metastasis are not well described. Methods: TET patients referred for consultation or screening for clinical trials are included. Imaging to evaluate for brain metastases was performed when clinically indicated or if required for screening. Tumor tissue from brain metastases was obtained for analysis, when available. Clinical characteristics and survival was evaluated and a systematic review of the literature on brain metastases associated with TETs was performed...
October 2017: Translational Lung Cancer Research
https://www.readbyqxmd.com/read/29097942/the-effect-of-diagnostic-imaging-on-surgical-treatment-planning-in-diseases-of-the-thymus
#12
REVIEW
Aurel Ottlakan, Bernadett Borda, Zita Morvay, Aniko Maraz, Jozsef Furak
Accurate imaging of the thymus is essential in the diagnosis and surgical treatment of both neoplastic and nonneoplastic conditions. Imaging of the thymus is a rather complex task, which affects both initial diagnosis and further surgical treatment planning. Imaging techniques include a wide armamentary of possibilities, from the most frequently used computed tomography (CT) to 18-fluorodeoxyglucose positron emission tomography- (18-FDG-PET-) CT and chemical shift magnetic resonance imaging (CS-MRI). In cases where surgical treatment is involved diagnostic imaging is of pivotal importance, not only in distinguishing benign from malignant disease but also in making a way among subtypes of thymic conditions...
2017: Contrast Media & Molecular Imaging
https://www.readbyqxmd.com/read/29036455/jlcs-medical-practice-guidelines-for-thymic-tumors-summary-of-recommendations
#13
Kohei Yokoi, Kazuya Kondo, Kiminori Fujimoto, Masaki Hara, Yoshihisa Kadota, Koji Kawaguchi, Hideo Kunitoh, Yoshihiro Matsuno, Jun Nakajima, Makoto Nishio, Kazuhiko Ogawa, Mitsugu Omasa
The Guideline Committee of the Japan Lung Cancer Society (JLCS) for Thymic Tumors published the Medical Practice Guideline for Thymic Tumors in Japanese as Chapter 3 of the Medical Practice Guidelines for Lung Cancers according to evidence-based medicine in December 2016. This medical practice guideline is the first for thymic epithelial tumors in Japan, and comprises a set of recommendations covering clinical diagnosis, treatment and pathological diagnosis. Thymic epithelial tumors include thymoma, thymic carcinoma and thymic neuroendocrine tumor...
December 1, 2017: Japanese Journal of Clinical Oncology
https://www.readbyqxmd.com/read/28777164/mr-imaging-of-mediastinal-masses
#14
REVIEW
Brett W Carter, Sonia L Betancourt, Marcelo F Benveniste
The mediastinum contains vital vascular and nonvascular structures and organs, and a wide variety of abnormalities may arise from this region of the thorax. Although mediastinal masses may be initially detected on chest radiography, cross-sectional imaging plays an important role in the identification and evaluation of mediastinal lesions, enabling the formulation of focused differential diagnoses and ultimately guiding management. Computed tomography (CT) is considered the imaging modality of choice for evaluating most mediastinal masses; however, the role of magnetic resonance (MR) imaging continues to expand, as it is superior to CT in differentiating between cystic and solid masses, identifying cystic and solid components within complex lesions, and distinguishing thymic hyperplasia and normal thymus from thymic epithelial neoplasms and other neoplasms...
August 2017: Topics in Magnetic Resonance Imaging: TMRI
https://www.readbyqxmd.com/read/28624025/quantitative-computed-tomography-texture-analysis-for-estimating-histological-subtypes-of-thymic-epithelial-tumors
#15
Koichiro Yasaka, Hiroyuki Akai, Masanori Nojima, Aya Shinozaki-Ushiku, Masashi Fukayama, Jun Nakajima, Kuni Ohtomo, Shigeru Kiryu
OBJECTIVES: To investigate whether high-risk thymic epithelial tumor (TET) (HTET) can be differentiated from low-risk TET (LTET) using computed tomography (CT) quantitative texture analysis. MATERIALS AND METHODS: The data of 39 patients (mean age, 58.6±14.1 years) (39 unenhanced CT (UECT) and 33 contrast-enhanced CT (CECT)) who underwent thymectomy for TET were retrospectively analyzed. A region of interest was placed to include the entire TET within the slice at its maximum diameter...
July 2017: European Journal of Radiology
https://www.readbyqxmd.com/read/28574817/intravoxel-incoherent-motion-diffusion-weighted-mr-imaging-parameters-predict-pathological-classification-in-thymic-epithelial-tumors
#16
Gang-Feng Li, Shi-Jun Duan, Lin-Feng Yan, Wen Wang, Yong Jing, Wei-Qiang Yan, Qian Sun, Shu-Mei Wang, Hai-Yan Nan, Tian-Yong Xu, Dan-Dan Zheng, Yu-Chuan Hu, Guang-Bin Cui
We evaluated the performance of intravoxel incoherent motion (IVIM) parameters for preoperatively predicting the subtype and Masaoka stage of thymic epithelial tumors (TETs). Seventy-seven patients with pathologically confirmed TETs underwent a diffusion weighted imaging (DWI) sequence with 9 b values. Differences in the slow diffusion coefficient (D), fast perfusion coefficient (D*), and perfusion fraction (f) IVIM parameters, as well as the multi b-value fitted apparent diffusion coefficient (ADCmb), were compared among patients with low-risk (LRT) and high-risk thymomas (HRT) and thymic carcinomas (TC), and between early stage (stages I and II) and advanced stage (stages III and IV) TET patients...
July 4, 2017: Oncotarget
https://www.readbyqxmd.com/read/28493800/iaslc-itmig-staging-system-and-lymph-node-map-for-thymic-epithelial-neoplasms
#17
REVIEW
Brett W Carter, Marcelo F Benveniste, Rachna Madan, Myrna C Godoy, Patricia M de Groot, Mylene T Truong, Melissa L Rosado-de-Christenson, Edith M Marom
Thymic epithelial neoplasms are rare malignancies that arise from the thymus and include thymoma, thymic carcinoma, and thymic neuroendocrine tumors. At least 15 different stage classifications have been proposed for thymic epithelial neoplasms and used to varying degrees in clinical practice, many of which have been constructed from small groups of patients. Traditionally, the Masaoka and Masaoka-Koga staging systems have been the schemes most commonly employed, and the latter has been recommended for use by the International Thymic Malignancy Interest Group (ITMIG)...
May 2017: Radiographics: a Review Publication of the Radiological Society of North America, Inc
https://www.readbyqxmd.com/read/28095872/an-unusual-combined-thymic-carcinoma-composed-of-squamous-cell-carcinoma-and-type-ab-thymoma-a-rare-case-report
#18
Yufeng Jiang, Yang Liu, Xiuying Shi, Xiaoyun Mao, Yang Zhao, Chuifeng Fan
BACKGROUND: Combined thymic carcinoma is a malignant neoplasm of the thymus recently added to the 4th edition of the World Health Organization (WHO) classification of tumors of the lung, pleura, thymus and heart. It involves at least one type of thymic carcinoma and another thymic epithelial tumor. The previously used term "combined thymic epithelial tumor" has been abandoned. CASE PRESENTATION: Here, we present an unusual case of combined thymic carcinoma of the thymus in a 44-year-old male who had suffered from fever, chest pain, chest tightness and shortness of breath...
January 17, 2017: Diagnostic Pathology
https://www.readbyqxmd.com/read/27920842/utility-of-electrocardiography-ecg-gated-computed-tomography-ct-for-preoperative-evaluations-of-thymic-epithelial-tumors
#19
Yoshiyuki Ozawa, Masaki Hara, Motoo Nakagawa, Yuta Shibamoto
BACKGROUND: Preoperative evaluation of invasion to the adjacent organs is important for the thymic epithelial tumors on CT. The purpose of our study was to evaluate the utility of electrocardiography (ECG)-gated CT for assessing thymic epithelial tumors with regard to the motion artifacts produced and the preoperative diagnostic accuracy of the technique. MATERIAL/METHODS: Forty thymic epithelial tumors (36 thymomas and 4 thymic carcinomas) were examined with ECG-gated contrast-enhanced CT using a dual source scanner...
2016: Polish Journal of Radiology
https://www.readbyqxmd.com/read/27666658/radiologic-response-to-neoadjuvant-treatment-predicts-histologic-response-in-thymic-epithelial-tumors
#20
Geoffrey B Johnson, Marie Christine Aubry, Eunhee S Yi, Chi Wan Koo, Sarah M Jenkins, Yolanda I Garces, Randolph S Marks, Stephen D Cassivi, Anja C Roden
INTRODUCTION: Neoadjuvant treatment might increase resectability of thymic epithelial tumors (TETs). No standardized pathologic grading scheme for tumor response is available. Also, it is unclear whether radiologic treatment response can predict pathologic response. METHODS: Patients with unresectable TETs who underwent neoadjuvant treatment before surgery at Mayo Clinic Rochester (1942-2014) were included. The pathologic tumor response grade (TRG) was based on Mandard grading (1994), ranging from TRG 1 (no viable tumor) to TRG 5 (no regression)...
February 2017: Journal of Thoracic Oncology
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