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Biomarker in plasma

Tao Wang, Xuan Zheng, Ruidong Li, Xintian Liu, Jinhua Wu, Xiaodan Zhong, Wenjun Zhang, Yujian Liu, Xingwei He, Wanjun Liu, Hongjie Wang, Hesong Zeng
Idiopathic pulmonary arterial hypertension (IPAH) is a severe cardiovascular disease that is a serious threat to human life. However, the specific diagnostic biomarkers have not been fully clarified and candidate regulatory targets for IPAH have not been identified. The aim of this study was to explore the potential diagnostic biomarkers and possible regulatory targets of IPAH. We performed a weighted gene coexpression network analysis and calculated module-trait correlations based on a public microarray data set (GSE703) and six modules were found to be related to IPAH...
October 14, 2018: Journal of Cellular Physiology
Takahisa Koyama, Shin Kariya, Yasuharu Sato, Yuka Gion, Takaya Higaki, Takenori Haruna, Tazuko Fujiwara, Akira Minoura, Soshi Takao, Yorihisa Orita, Kengo Kanai, Masami Taniguchi, Kazunori Nishizaki, Mitsuhiro Okano
BACKGROUND: IgG4 production is regulated by type 2 (IL-4 and IL-13) and regulatory (IL-10) cytokines involved in the pathophysiology of chronic rhinosinusitis (CRS). We sought to determine the pathophysiological characteristics of IgG4-positive cells in sinonasal tissues in CRS, especially eosinophilic CRS (ECRS). METHODS: IgG4-positive cells in uncinate tissues (UT) and nasal polyps (NP) were examined by immunohistochemistry. Associations between the number of IgG4-positive cells and clinicopathological factors were analyzed...
October 10, 2018: Allergology International: Official Journal of the Japanese Society of Allergology
I Brandts, M Teles, A Tvarijonaviciute, M L Pereira, M A Martins, L Tort, M Oliveira
The present study aimed to evaluate the effects of ~45 nm nanoplastics (NPs) on the marine fish Dicentrarchus labrax after a short-term exposure. Animals were exposed to a concentration range of NPs for 96 h and liver, plasma and skin mucus sampled. Assessed endpoints included biochemical biomarkers and expression of genes related to lipid metabolism, immune system and general cell stress. Molecular signaling pathways related to lipid metabolism, pparα and pparγ were significantly increased after exposure to NPs...
October 11, 2018: Genomics
Jia-Huei Yan, Xin-Yuan Cai, Ying-Hsien Huang
BACKGROUND: Febrile children are often evaluated for the risk of bacterial infections in the pediatric emergency department (PER). Hepcidin is an acute phase inflammatory protein. In this study, we examined the plasma hepcidin levels in febrile children. METHODS: This study was conducted at a pediatric emergency department with 123 febrile children. We measured plasma hepcidin levels using an enzyme-linked immunosorbent assay. We further evaluated clinical characteristics and routine blood tests along with the hepcidin levels...
September 20, 2018: Pediatrics and Neonatology
Sun-Ho Han, Jong-Chan Park, Min Soo Byun, Dahyun Yi, Jun Ho Lee, Dong Young Lee, Inhee Mook-Jung
Cerebral β-amyloid (cAβ) deposition and cholinergic dysfunction have been considered as major pathological and functional hallmarks of Alzheimer's disease (AD). Acetylcholinesterase (AChE) is one of the major cholinergic enzymes, and there is no report to show the relationship between cAβ accumulation and peripheral AChE alteration in early stage of AD pathogenesis. Recent studies demonstrate that cAβ starts to deposit 15-20 years ahead of symptomatic appearance and this preclinical AD is important for early diagnosis of disease...
September 8, 2018: Neurobiology of Aging
Ronghui Zheng, Yusheng Zhang, Chao Fang, Mengyun Chen, Fukun Hong, Jun Bo
Nonylphenol (NP) and Cadmium (Cd) are two common contaminants that can be detected in aquatic environments. Nevertheless, the combined toxicity of NP and Cd at environmentally relevant concentrations in aquatic organisms has not been thoroughly characterized to date. In the present study, the interactions between NP and Cd on male Sebastiscus marmoratus were studied. After 21 days of exposure, the brain aromatase activity was observed to be significantly induced by 100 ng/L NP and 40 μg/L Cd, whereas all of the concentrations of co-treatment resulted in an increase in brain aromatase activity...
October 10, 2018: Comparative Biochemistry and Physiology. Toxicology & Pharmacology: CBP
J Singh, M Cerghet, L M Poisson, I Datta, K Labuzek, H Suhail, R Rattan, Shailendra Giri
Identification of non-invasive biomarkers of disease progression in multiple sclerosis (MS) is critically needed for monitoring the disease progression and for effective therapeutic interventions. Urine is an attractive source for non-invasive biomarkers because it is easily obtained in the clinic. In search of a urine metabolite signature of progression in chronic experimental autoimmune encephalomyelitis (EAE), we profiled urine at the chronic stage of the disease (day 45 post immunization) by global untargeted metabolomics...
October 12, 2018: Journal of Neuroimmune Pharmacology: the Official Journal of the Society on NeuroImmune Pharmacology
Shelby Barnett, Kayode Ogungbenro, Karelle Menochet, Hong Shen, Griffith W Humphreys, Aleksandra Galetin
Endogenous biomarkers can be clinically relevant tools for the assessment of transporter function in vivo and corresponding drug-drug interactions (DDIs). The aim of this study was to perform systematic evaluation of plasma data obtained for 20 endogenous molecules in the same healthy subjects (n=8-12) in the absence and presence of OATP inhibitor rifampicin (600mg s.d.). The extent of rifampicin DDI magnitude (AUCR), estimated fraction transported (fT) and baseline variability were compared across the biomarkers and relative to rosuvastatin and coproporphyrin I (CPI)...
October 12, 2018: Journal of Pharmacology and Experimental Therapeutics
Ping Lin, Bingyu Ding, Yunqiang Wu, Ke Dong, Qingtian Li
BACKGROUND: Major depressive disorder (MDD) is related to human's immune status, and immunological indicators such as mitogen stimulated cell proliferation and cytokines may become candidate biomarkers for disease diagnosis. METHODS: One hundred diagnosed major depressive disorder subjects and 100 health controls were enrolled in this study. Phytohaemagglutinin and lipopolysaccharide stimulated cell proliferations and cytokine concentrations were detected in peripheral blood mononuclear cells from both groups...
October 12, 2018: BMC Psychiatry
Katarzyna Szczeklik, Tomasz Mach, Dorota Cibor, Danuta Owczarek, Jacek Sapa, Monika Papież, Jolanta Pytko-Polończyk, Wirginia Krzyściak
Diagnostics of Crohn's disease (CD) requires noninvasive biomarkers facilitating early detection and differentiation of the disease. Therefore, in this study, we aimed to determine the relationship between paraoxonase-1 (PON-1), the severity of CD, oxidative stress, and inflammation in CD. The CD activity index was based on the current classification. Plasma PON-1 was measured in 47 patients with CD, and in 23 control volunteers. Using quantitative variables such as receiver operating characteristics (ROC) (area under the curve (AUC)), the diagnostic utility of PON-1 in differentiating the severity of CD was assessed...
October 11, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
Valentina Giudice, Angélique Biancotto, Zhijie Wu, Foo Cheung, Julián Candia, Giovanna Fantoni, Sachiko Kajigaya, Olga Rios, Danielle Townsley, Xingmin Feng, Neal S Young
Single-stranded oligonucleotides containing deoxyuridine are aptamers (SOMAmers) that can bind proteins with high specificity and affinity, and slow dissociation rates. SOMAscan, an aptamer-based proteomic technology, allows measurement of more than 1,300 proteins simultaneously for identification of new disease biomarkers. The aim of the present study was to identify new serum and plasma protein markers for diagnosis of acquired aplastic anemia (AA) and response to immunosuppressive therapies (IST). SOMAscan was used to screen 1,141 serum proteins in 28 AA patients before and after therapy and 1,317 plasma proteins in 7 SAA patients treated with standard IST and a thrombopoietin receptor agonist...
October 9, 2018: Experimental Hematology
J B Whitlam, L Ling, A Skene, J Kanellis, F L Ierino, H R Slater, D L Bruno, D A Power
Graft-derived cell-free DNA (donor-derived cell-free DNA) is an emerging marker of kidney allograft injury. Studies examining the clinical validity of this biomarker have previously used the graft fraction, or proportion of total cell-free DNA that is graft-derived. The present study evaluated the diagnostic validity of absolute measurements of graft-derived cell-free DNA, as well as calculated graft fraction, for the diagnosis of graft dysfunction. Plasma graft-derived cell-free DNA, total cell-free DNA and graft fraction were correlated with biopsy diagnosis as well as individual Banff scores...
October 12, 2018: American Journal of Transplantation
Esther Rodríguez-Gallego, Laura Tarancón-Diez, Felipe García, Jorge Del Romero, Jose Miguel Benito, Verónica Alba, Pol Herrero, Anna Rull, Beatriz Dominguez-Molina, Onofre Martinez-Madrid, Luisa Martin-Pena, Federico Pulido, Agathe León, Carmen Rodríguez, Norma Rallón, Joaquim Peraire, Consuelo Viladés, Manuel Leal, Francesc Vidal, Ezequiel Ruiz-Mateos
Background: Elite Controllers (EC) spontaneously control plasma HIV-1-RNA without antiretroviral therapy. However, 25% lose virological control over time. The aim of this work was to study the proteomic profile that preceded this loss of virological control to identify potential biomarkers. Methods: Plasma samples from EC who spontaneously lost virological control (Transient Controllers, TC), at two and one year before the loss of control, were compared with a control group of EC who persistently maintained virological control during the same follow-up period (Persistent Controllers, PC)...
October 12, 2018: Journal of Infectious Diseases
Takele Feyera, Pan Zhou, Morakot Nuntapaitoon, Kristina Ulrich Sørensen, Uffe Krogh, Thomas Sønderby Bruun, Stig Purup, Henry Jørgensen, Hanne Damgaard Poulsen, Peter Kappel Theil
The aims of this study were to investigate 1) the effect of high dietary fiber (DF; 19.3 to 21.7%) supplemented to late gestating sows on mammary uptake and metabolism of energy substrates as well as colostrum production and 2) the ontogeny of colostral fat and lactose synthesis using mammary carbon balance, and colostral protein using IgG as a biomarker. Sows were fed either a control diet (CON) consisting of a standard gestation diet (14.6% DF) until d 108 of gestation and a transition diet (16.8% DF) from d 109 of gestation until farrowing or a high DF treatment where part of the daily ration was replaced with a high DF supplement (FIB)...
October 12, 2018: Journal of Animal Science
Tim Dierckx, Bram Verstockt, Séverine Vermeire, Johan van Weyenbergh
Background and aims: Glycoprotein acetylation (GlycA) is a novel nuclear magnetic resonance (NMR) biomarker measured in serum or plasma, which summarizes signal originating from glycan groups of certain acute phase glycoproteins. This biomarker has been shown to be robustly associated to cardiovascular and short-term all-cause mortality, and to disease severity in several inflammatory conditions. We investigated GlycA levels in a cohort of healthy individuals (HC), Crohn's disease (CD) and ulcerative colitis (UC) patients prior to and after therapeutic control of inflammation...
October 11, 2018: Journal of Crohn's & Colitis
Ivana Nikolic, Lai-Ming Yung, Peiran Yang, Rajeev Malhotra, Samuel D Paskin-Flerlage, Teresa Dinter, Geoffrey A Bocobo, Kathleen E Tumelty, Anthony J Faugno, Luca Troncone, Megan E McNeil, Xiuli Huang, Kathryn R Coser, Carol S C Lai, Paul D Upton, Marie Jose Goumans, Roham T Zamanian, C Gregory Elliott, Arthur Lee, Wei Zheng, Stephen P Berasi, Christine Huard, Nicholas W Morrell, Raymond T Chung, Richard W Channick, Kari E Roberts, Paul B Yu
RATIONALE: Bone Morphogenetic Protein 9 (BMP9) is a circulating endothelial quiescence factor with protective effects in pulmonary arterial hypertension (PAH). Loss-of-function mutations in BMP9, its receptors and downstream effectors have been reported in heritable PAH. OBJECTIVES: We sought to determine how an acquired deficiency of BMP9 signaling might contribute to PAH. METHODS AND RESULTS: Plasma levels of BMP9 and antagonist soluble Endoglin (sEng) were measured in Group 1 PAH, Group 2 and 3 pulmonary hypertension (PH), and in patients with severe liver disease without PAH...
October 12, 2018: American Journal of Respiratory and Critical Care Medicine
Petter Bjornstad, Sunita K Singh, Janet K Snell-Bergeon, Julie A Lovshin, Yuliya Lytvyn, Leif E Lovblom, Marian J Rewers, Genevieve Boulet, Vesta Lai, Josephine Tse, Leslie Cham, Andrej Orszag, Alanna Weisman, Hillary A Keenan, Michael H Brent, Narinder Paul, Vera Bril, Bruce A Perkins, David Z I Cherney
OBJECTIVE: Our aim was to define the relationships between plasma biomarkers of kidney injury and intrarenal hemodynamic function (glomerular filtration rate [GFR], effective renal plasma flow [ERPF], renal vascular resistance [RVR]) in adults with type 1 diabetes (T1D). METHODS: The study sample consisted of patients with longstanding T1D (≥50 years duration); 44 Diabetic Kidney Disease (DKD) resistors (eGFR >60mL/min/1.73m2 and <30mg/day urine albumin excretion) and 22 with DKD, in addition to 73 controls...
October 12, 2018: Diabetes, Obesity & Metabolism
Hitomi Yamamoto-Imoto, Daria Zamolodchikov, Zu-Lin Chen, S Lloyd Bourne, Syeda Rizvi, Pradeep Singh, Erin H Norris, Frances Weis-Garcia, Sidney Strickland
Introduction: Accumulation of β-amyloid is a pathological hallmark of Alzheimer's disease (AD). β-Amyloid activates the plasma contact system leading to kallikrein-mediated cleavage of intact high-molecular-weight kininogen (HKi) to cleaved high-molecular-weight kininogen (HKc). Increased HKi cleavage is observed in plasma of AD patients and mouse models by Western blot. For potential diagnostic purposes, a more quantitative method that can measure HKc levels in plasma with high sensitivity and specificity is needed...
2018: Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring
David de Gonzalo-Calvo, Germán Cediel, Christian Bär, Julio Núñez, Elena Revuelta-Lopez, Josep Gavara, César Ríos-Navarro, Vicenta Llorente-Cortes, Vicente Bodí, Thomas Thum, Antoni Bayes-Genis
Reliable noninvasive prognostic biomarkers for left ventricular (LV) remodeling in ST-segment elevation myocardial infarction (STEMI) are needed. This study aimed to evaluate a panel of circulating microRNAs (miRNAs) as biomarkers of LV remodeling using cardiovascular magnetic resonance (CMR). We prospectively evaluated patients with a first STEMI treated with primary percutaneous coronary intervention who underwent CMR imaging at 1 week and 6 months after STEMI (n = 70). miRNAs were measured using PCR-based technologies in plasma samples collected at admission...
October 11, 2018: Scientific Reports
Cécile Bergua, Hélène Chiavelli, Yves Allenbach, Louiza Arouche-Delaperche, Christophe Arnoult, Gwladys Bourdenet, Laetitia Jean, Rachid Zoubairi, Nicolas Guerout, Michael Mahler, Olivier Benveniste, Laurent Drouot, Olivier Boyer
OBJECTIVES: In autoimmunity, autoantibodies (aAb) may be simple biomarkers of disease or true pathogenic effectors. A form of idiopathic inflammatory myopathy associated with anti-signal recognition particle (SRP) or anti-3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR) aAb has been individualised and is referred to as immune-mediated necrotising myopathy (IMNM). The level of aAb correlates with IMNM activity and disease may respond to immunosuppression, suggesting that they are pathogenic...
October 11, 2018: Annals of the Rheumatic Diseases
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