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Biomarker in plasma

Takatoyo Kiko, Akiomi Yoshihisa, Yuki Kanno, Tetsuro Yokokawa, Satoshi Abe, Makiko Miyata-Tatsumi, Tomofumi Misaka, Masayoshi Oikawa, Atsushi Kobayashi, Takafumi Ishida, Yasuchika Takeishi
Sarcoidosis is a systemic granulomatous disease including heart (cardiac sarcoidosis, CS). It has recently been reported that isolated CS, which presenting primarily cardiac symptoms without clinical evidence of sarcoid involvement in other organs. Diagnostic and prognostic biomarkers of CS, especially in isolated CS, have not yet been established.We studied plasma levels of angiotensin-converting enzyme (ACE), soluble interleukin-2 receptor (sIL-2R), B-type natriuretic peptide (BNP) and cardiac troponin I (cTnI) in consecutive 172 patients with diagnosed sarcoidosis...
August 11, 2018: International Heart Journal
Qixin Leng, Jen-Hui Tsou, Min Zhan, Feng Jiang
PURPOSE: Fucosyltransferases (FUTs) catalyze fucosylation, which plays a central role in biological processes. Aberrant fucosylation is associated with malignant transformation. Here we investigated whether transcriptional levels of genes coding the FUTs in plasma could provide cell-free circulating biomarkers for lung cancer. METHODS: mRNA expression of all 13 Futs (Fut1-11, Pofut1, and Pofut2) was evaluated by PCR assay in 48 lung tumor tissues and the 48 matched noncancerous lung tissues, and plasma of 64 lung cancer patients and 32 cancer-free individuals to develop plasma Fut biomarkers...
August 12, 2018: Journal of Cancer Research and Clinical Oncology
Ane S Kværner, Dong Hang, Edward L Giovannucci, Walter C Willett, Andrew T Chan, Mingyang Song
Background: A major pathway through which obesity increases the risk of cardiometabolic diseases and cancer is by inducing hormonal and metabolic abnormalities, including hyperinsulinemia and altered insulin-like growth factor (IGF) signaling. However, little is known about the influence of lifetime adiposity on the relevant biomarkers. Objective: The aim of this study was to examine associations of trajectories of body fatness with plasma biomarker concentrations of the insulin-IGF system in 2 large prospective cohorts of US men and women...
August 1, 2018: American Journal of Clinical Nutrition
Sinead Tj McDonagh, Lee J Wylie, Paul T Morgan, Anni Vanhatalo, Andrew M Jones
BACKGROUND: Ingestion of nitrate (NO3 - )-containing vegetables, alcohol and polyphenols, separately, can reduce blood pressure (BP). However, the pharmacokinetic response to the combined ingestion of NO3 - and polyphenol-rich or low polyphenol alcoholic beverages is unknown. AIM: The aim of this study was to investigate how the consumption of low and high polyphenolic alcoholic beverages combined with a NO3 - -rich meal can influence NO3 - metabolism and systemic BP...
August 13, 2018: Nutrition and Health
Wenjie Zhu, Mei Liu, Ying Fan, Fei Ma, Ningzhi Xu, Binghe Xu
BACKGROUND: Circulating microRNAs (miRNAs) have been indicated as predictive biomarkers in breast cancer. We aimed to explore the association of plasma miRNA dynamics with response to neoadjuvant chemotherapy (NCT) and disclose early markers for predicting sensitivity. METHODS: One hundred and nine patients with operable or locally advanced breast cancer, who participated in a prospective clinical trial and received NCT, were analyzed. Blood samples were collected before random assignment, after two cycles of chemotherapy (C2) and before surgery...
August 11, 2018: Cancer Medicine
Xiaoyan Chen, Jinguo Liu, Mengchan Zhu, Bijie Hu, Fengxi Bai, Wenting Jin, Jian Zhou, Cuicui Chen, Yuanlin Song, Jue Pan
BACKGROUND: Progranulin is a pleiotropic glycosylated protein precursor that plays an important role in inflammation. Limited data exist regarding the role of progranulin in the acute exacerbation of chronic obstructive pulmonary disease (AECOPD). OBJECTIVES: The study is to assess the efficiency of progranulin as a circulating biomarker of AECOPD. METHODS: The plasma progranulin levels were measured and compared in patients with AECOPD (n = 52), patients with stable COPD (n = 56) and healthy controls (n = 36)...
August 12, 2018: Clinical Respiratory Journal
Matthew F Buas, Christopher I Li, Garnet L Anderson, Margaret S Pepe
BACKGROUND: Biomarker candidates are often ranked using P-values. Standard P-value calculations use normal or logit-normal approximations, which may not be correct for small P-values and small sample sizes common in discovery research. METHODS: We compared exact P-values, correct by definition, with logit-normal approximations in a simulated study of 40 cases and 160 controls. The key measure of biomarker performance was sensitivity at 90% specificity. Data for 3000 uninformative false markers and 30 informative true markers were generated randomly...
August 9, 2018: Cancer Epidemiology
Catherine Augello, Jessica M Noll, Timothy J Distel, Jolita Wainright, Charles Stout, Byron D Ford
The use of blood biomarkers for stroke has been long considered an excellent method to determine the occurrence, timing, subtype, and severity of stroke. In this study, venous blood was obtained from ischemic stroke patients after stroke onset and compared with age and sex-matched controls. We used a multiplex panel of 37 inflammatory molecules, analyzed using Luminex MagPix technology, to identify the changes in plasma proteins after ischemic stroke. We identified eight key molecules that were altered within the blood of stroke patients as compared to controls...
August 9, 2018: Brain Research
Nicklas Juel Pedersen, David Hebbelstrup Jensen, Giedrius Lelkaitis, Katalin Kiss, Birgitte Wittenborg Charabi, Henrik Ullum, Lena Specht, Ane Yde Schmidt, Finn Cilius Nielsen, Christian von Buchwald
BACKGROUND: MicroRNAs (miRNAs) hold promise as diagnostic cancer biomarkers. Here we aimed to define the miRNome in oral squamous cell carcinoma (OSCC) and normal oral mucosa (NOM), and to identify and validate new diagnostic miRNAs and miRNA combinations in formalin-fixed paraffin-embedded (FFPE) tissue samples and plasma samples. METHODS: We performed next-generation miRNA sequencing in FFPE tissue samples of OSCC (n = 80) and NOM (n = 8). Our findings were validated by quantitative polymerase chain reaction (qPCR) analysis of OSCC (n = 195) and NOM (n = 103) FFPE tissue samples, and plasma samples from OSCC patients (n = 55) and healthy persons (n = 18)...
August 2018: Oral Oncology
Kathiroli Sujithra, Subramani Srinivasan, Dhananjayan Indumathi, Veerasamy Vinothkumar
Therapeutic approaches based on dietary compounds obtained from food products to handle diabetes involving oxidative stress and inflammation. Garlic is a common spice and has a long history as a folk remedy. Allyl methyl sulfide (AMS) is a potential garlic-derived organosulfur compound displaying a substantial range of optimistic actions in various diseases. Herein, we investigated the potential role of AMS in ameliorating the effects of oxidative stress and inflammation in the liver of streptozotocin (STZ)-induced experimental rats...
August 8, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
Viktoriia Burkina, Galia Zamaratskaia, Sidika Sakalli, Pham Thai Giang, Vit Kodes, Roman Grabic, Josef Velisek, Jan Turek, Jitka Kolarova, Vladimir Zlabek, Tomas Randak
Monitoring the contamination level in aquatic environments and assessing the impact on aquatic life occurs throughout the world. In the present study, an approach based on a combination of biomarkers and the distribution of various industrial and municipal pollutants was used to investigate the effect of aquatic environmental contamination on fish. Monitoring was performed in ten rivers in the Czech Republic (Berounka, Dyje, Elbe, Lužnice, Odra, Ohře, Otava, Sázava, Svratka, and Vltava rivers, with one or two locations in each river) at the same sites that were regularly monitored within the Czech National Monitoring Program in 2007-2011...
August 8, 2018: Ecotoxicology and Environmental Safety
Yanli Lin, Qixin Leng, Min Zhan, Feng Jiang
The early detection of lung cancer is a major clinical challenge. Long noncoding RNAs (lncRNAs) have important functions in tumorigenesis. Plasma lncRNAs directly released from primary tumors or the circulating cancer cells might provide cell-free cancer biomarkers. The objective of this study was to investigate whether the lncRNAs could be used as plasma biomarkers for early-stage lung cancer. By using droplet digital polymerase chain reaction, we determined the diagnostic performance of 26 lung cancer-associated lncRNAs in plasma of a development cohort of 63 lung cancer patients and 33 cancer-free individuals, and a validation cohort of 39 lung cancer patients and 28 controls...
August 8, 2018: Translational Oncology
Shiv Ram Krishn, Amrita Singh, Nicholas Bowler, Alexander N Duffy, Andrea Friedman, Carmine Fedele, Senem Kurtoglu, Sushil K Tripathi, Kerith Wang, Adam Hawkins, Aejaz Sayeed, Chirayu P Goswami, Madhukar L Thakur, Renato V Iozzo, Stephen C Peiper, William K Kelly, Lucia R Languino
The αvβ3 integrin has been shown to promote aggressive phenotypes in many types of cancers, including prostate cancer. We show that GFP-labeled αvβ3 derived from cancer cells circulates in the blood and is detected in distant lesions in NOD scid gamma (NSG) mice. We therefore hypothesized that αvβ3 travels through exosomes and we tested its levels in pools of vesicles, which we designate extracellular vesicles highly enriched in exosomes (ExVs), and in exosomes isolated from the plasma of prostate cancer patients...
August 8, 2018: Matrix Biology: Journal of the International Society for Matrix Biology
Mohsen Dorraki, Anahita Fouladzadeh, Stephen J Salamon, Andrew Allison, Brendon J Coventry, Derek Abbott
C-reactive protein (CRP) is an acute-phase plasma protein that can be used as a biomarker for activation of the immune system. A spectral analysis of CRP level over time for patients with gynaecological tumours has been reported by Madondo et al., using a periodogram method, suggesting that there is no significant periodicity in the data. In our study, we investigate the impact of low sample number on periodogram analysis, for non-uniform sampling intervals-we conclude that data of Madondo et al. cannot rule out periodic behaviour...
August 10, 2018: Scientific Reports
Kerstin Zwirner, Franz J Hilke, German Demidov, Stephan Ossowski, Cihan Gani, Olaf Rieß, Daniel Zips, Stefan Welz, Christopher Schroeder
BACKGROUND AND PURPOSE: Radiochemotherapy is a standard treatment option for patients with head and neck cancer (HNSCC). During radiation, local toxicities are common and need to be differentiated from infections. As levels of circulating cell-free DNA (cfDNA) are known to be elevated during infections, cfDNA might complement clinical parameters. The aim of the study was to investigate the dynamics of cfDNA during radiochemotherapy. MATERIAL AND METHODS: In total, 78 blood samples of 20 patients with HNSCC were analysed in this prospective biomarker study...
August 7, 2018: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
Premkumari Kumarathasan, Renaud Vincent, Erica Blais, Agnieszka Bielecki, Josée Guénette, Alain Filiatreault, Orly Brion, Sabit Cakmak, Errol M Thomson, Robin Shutt, Lisa Marie Kauri, Mamun Mahmud, Ling Liu, Robert Dales
BACKGROUND: There is a paucity of mechanistic information that is central to the understanding of the adverse health effects of source emission exposures. To identify source emission-related effects, blood and saliva samples from healthy volunteers who spent five days near a steel plant (Bayview site, with and without a mask that filtered many criteria pollutants) and at a well-removed College site were tested for oxidative stress, inflammation and endothelial dysfunction markers. METHODS: Biomarker analyses were done using multiplexed protein-array, HPLC-Fluorescence, EIA and ELISA methods...
August 10, 2018: Particle and Fibre Toxicology
Kheng Siang Ted Ng, Angelia Sia, Maxel K W Ng, Crystal T Y Tan, Hui Yu Chan, Chay Hoon Tan, Iris Rawtaer, Lei Feng, Rathi Mahendran, Anis Larbi, Ee Heok Kua, Roger C M Ho
The effect of horticultural therapy (HT) on immune and endocrine biomarkers remains largely unknown. We designed a waitlist-control randomized controlled trial to investigate the effectiveness of HT in improving mental well-being and modulating biomarker levels. A total of 59 older adults was recruited, with 29 randomly assigned to the HT intervention and 30 to the waitlist control group. The participants attended weekly intervention sessions for the first 3 months and monthly sessions for the subsequent 3 months...
August 9, 2018: International Journal of Environmental Research and Public Health
Aasif Ahmad Sheikh, O K Hooda, Ankita Kalyan, Aarti Kamboj, Seid Mohammed, Mohanned Alhussien, Srinu Reddi, Panreiphy Gachuiwo Shimray, Ankita Rautela, Sujata Pandita, Suman Kapila, Sachinandan De, A K Dang
The embryonic mortality in cows is a growing concern for an ever-expanding dairy industry. The current study was an attempt to shorten the open period of dairy cows having suffered embryonic loss by diagnosing them at an earlier stage. The blood samples were collected from the Karan Fries (KF) cows on days 0 (day of AI/estrus), 4, 8, 12, 14, 16, 18, 21, 24, 28, 35 and 42 post insemination. The experimental animals were then categorized into pregnant (P), conception failure/early embryonic mortality (EEM) and late embryonic mortality cows (LEM), based on progesterone assay, ultrasonography and per-rectal palpation...
July 29, 2018: Theriogenology
Aydan Caglayan, Doruk Cevdi Katlan, Zafer Selcuk Tuncer, Kunter Yuce, Hasan Berkan Sayal, Belma Kocer-Gumusel
OBJECTIVES: Uterine myomas (UM) are responsible for significant morbidity and have adverse effects on quality of life in women. Reactive oxygen species (ROS) and antioxidant enzymes (AOE), as well as sex steroids play important roles in the reproductive physiology processes. Thus, we aimed to investigate the role of oxidant-antioxidant status in UM by measuring the AOE activities and lipid peroxidation (LPO) levels. This is the first study assessing these parameters together in UM based on also menopausal status and evaluating possible correlations between AOE activities, LPO markers, tumor biomarkers, female reproductive system hormone levels, comprehensively...
August 1, 2018: European Journal of Obstetrics, Gynecology, and Reproductive Biology
Takeshi Osonoi, Maki Gouda, Mamiko Kubo, Kenji Arakawa, Toshio Hashimoto, Masanori Abe
BACKGROUND: Albuminuria characterizes the progression of kidney injury. The effect of canagliflozin on the excretion of microalbumin was assessed for investigating its renoprotective potential in Japanese patients with type 2 diabetes mellitus (T2DM). PATIENTS AND METHODS: Twenty Japanese patients with T2DM and microalbuminuria were enrolled and administered with 100 mg of canagliflozin once a day for 12 weeks. These subjects were admitted to the clinic at the start and end of the treatment period for 24-h urine collection...
August 10, 2018: Diabetes Technology & Therapeutics
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