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SEP or micropeptides

Ashutosh Chaturvedi, Arun Kumar
Background: Syncope is a common clinical presentation in emergency department. The diagnostic workup for syncope causes significant man-hour loss and expensive investigations. Most often the battery of investigations does not lead to any conclusive diagnosis. Materials and Methods: This was a descriptive study in which included 50 consecutive patients with the diagnosis of syncope. These patients were admitted to a tertiary care hospital between Sep 2009 to Aug 2011...
January 2018: Journal of the Association of Physicians of India
Chi Chung Foo, Samuel Ho Ting Poon, Rosemaire Hon Yiu Chiu, Wai Yiu Lam, Lam Chi Cheung, Wai Lun Law
BACKGROUND: Despite studies showing superior results in terms of reduced stoma rate and higher primary anastomosis rate, the safety of bridge to surgery stenting (BTS stent) for left-sided malignant colonic obstruction, especially in oncological terms, remains a concern. AIM: The aim of this meta-analysis was to evaluate whether BTS stent is a safe alternative to emergency surgery (EmS). METHODS: Randomized control trials (RCTs) comparing BTS stent and EmS for left-sided colonic obstruction caused by primary cancer of the colon, up to Sep 2018, were retrieved from the Pubmed, Embase database, clinical trials registry of U...
October 19, 2018: Surgical Endoscopy
Xiang-Yu Zhang, Yan-Fang Sui, Tie-Cheng Guo, Sai-Hua Wang, Yan Hu, Yin-Shan Lu
Paired associative stimulation (PAS), combining transcranial magnetic stimulation (TMS) with electrical peripheral nerve stimulation (PNS) in pairs with an optimal interstimulus interval (ISI) in between, has been shown to influence the excitability of the motor cortex (MC) in humans. However, the underlying mechanisms remain unclear. This study was designed to explore an optimal protocol of PAS, which can modulate the excitability of MC in rats, and to investigate the underlying mechanisms. The resting motor thresholds (RMTs) of TMS-elicited motor evoked potentials (MEPs) recorded from the gastrocnemius muscle and the latency of P1 component of somatosensory evoked potentials (SEPs) induced by electrical tibial nerve stimulation were determined in male Sprague-Dawley rats (n=10)...
October 2018: Current medical science
Rachel F McCloud, Mesfin A Bekalu, Nicole Maddox, Sara J Minsky, Kasisomayajula Viswanath
BACKGROUND: National Cancer Institute-designated cancer centers provide key cancer research, prevention, and treatment services to members of their catchment area. Characterization of these areas may be complex given the diverse needs of the populations within, particularly those from low socioeconomic position (SEP). The purpose of this paper is to describe the characterization of the Dana-Farber/Harvard Cancer (DF/HCC) catchment area through using a two-pronged approach. METHODS: Participants (n=1,511) were recruited through 1) an online, probability-based survey (n=1,013) and 2) a supplementary, in-person survey from priority groups (African Americans, Latinos, blue collar workers, low SEP, homeless, n=498) within Massachusetts...
October 19, 2018: Cancer Epidemiology, Biomarkers & Prevention
Pooja Ghatalia, Rebecca Koenigsberg, David Pisarcik, Elizabeth A Handorf, Daniel M Geynisman, Matthew Zibelman
Background: We previously published an analysis of clinical trials in renal cell carcinoma (RCC) using the publicly available registry. Here we present a 3-year update to understand clinical research current trends in RCC compared to 2013. Methods: The Website's advanced search function was used to search for RCC trials. The characteristics of the trial were extracted, summarized and compared to 2013 data using Fisher's exact tests. Results: We locked our search on May 26, 2016 with 165 trials eligible, compared with 169 trials on Sep 25, 2013...
November 27, 2017: Kidney cancer
Tomasz Tuzimski, Dominika Pieniążek, Grzegorz Buszewicz, Grzegorz Teresiński
Different extraction and clean-up protocols, based on either the dispersive solid-phase extraction (d-SPE) and the quick, easy, cheap, effective, rugged, and safe (QuEChERS) approach, were optimized and compared for the determination of selected bisphenols such as bisphenol A (BPA) and bisphenol S (BPS) in breast milk samples. QuEChERS-based sample preparation procedure was optimized by evaluation of different clean-up sorbents including zirconium-based sorbents (Z-Sep and Z-Sep Plus) and primary secondary amine...
October 17, 2018: Journal of AOAC International
Marnix J M van Agtmaal, Alfons J H M Houben, Vera de Wit, Ronald M A Henry, Nicolaas C Schaper, Pieter C Dagnelie, Carla J van der Kallen, Annemarie Koster, Simone J Sep, Abraham A Kroon, Jacobus F A Jansen, Paul A Hofman, Walter H Backes, Miranda T Schram, Coen D A Stehouwer
OBJECTIVE: Structural brain abnormalities are key risk factors for brain diseases, such as dementia, stroke, and depression, in type 2 diabetes. It is unknown whether structural brain abnormalities already occur in prediabetes. Therefore, we investigated whether both prediabetes and type 2 diabetes are associated with lacunar infarcts (LIs), white matter hyperintensities (WMHs), cerebral microbleeds (CMBs), and brain atrophy. RESEARCH DESIGN AND METHODS: We used data from 2,228 participants (1,373 with normal glucose metabolism [NGM], 347 prediabetes, and 508 type 2 diabetes (oversampled); mean age 59...
October 16, 2018: Diabetes Care
Raffaele Nardone, Francesco Brigo, Viviana Versace, Luca Sebastianelli, Monica Christova, Stefan Golaszewski, Leopold Saltuari, Eugen Trinka
BACKGROUND: Several studies have applied electrophysiological techniques to physiologically characterize corticobasal degeneration (CBD). METHODS: We performed a systematic literature search of these studies and reviewed all 25 identified articles. RESULTS: Conventional electroencephalography (EEG) is usually normal even in the late stages of disease. Quantitative EEG (qEEG) with spectral analysis revealed mainly lateralized abnormalities, such as an increase of slow wave activity and occasionally the occurrence of sharp waves, and a significant increase of coherence between left parietal-right premotor areas...
October 13, 2018: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
Virginie Prevost, Bénédicte Clarisse, Natacha Heutte, Alexandra Leconte, Cécile Bisson, Rachel Bignon, Sonia Cauchin, Maryline Feuillet, Sylvie Gehanne, Maud Gicquère, Marie-Christine Grach, Cyril Guillaumé, Christine Le Gal, Joelle Le Garrec, Franck Lecaer, Isabelle Lepleux, Anne-Laure Millet, Marie-Claude Ropartz, Nathalie Roux, Virith Sep Hieng, Carole Van Delook, Constance Bechet, Aline Le Chevalier, Claire Delorme
Pain, one of the most feared symptoms for patients with cancer, remains insufficiently alleviated and impairs quality of life. Therapeutic patient education (TPE) is a relevant approach to this problem while allowing patients to develop skills to better manage their pain. In the "Basse-Normandie" French region, the management of pain relies on two organized networks, thus allowing proximity and accessibility for all concerned. In this context, our team has begun a broad five-step research program that is part of a regional health policy: (1) training in TPE of 10 doctor/nurse pairs; (2) identification of educational expectations of patients and their relatives in the field of cancer pain; (3) design and optimization of a TPE program dedicated to cancer pain; (4) regional pilot study aiming to assess the feasibility, quality and transferability of the program; (5) evaluation of the TPE program by interventional comparative randomization at the national level...
October 13, 2018: Bulletin du Cancer
Lida Sharifi-Rad, Seyedeh-Sanam Ladi-Seyedian, Hossein Amirzargar, Abdol-Mohammad Kajbafzadeh
OBJECTIVE: To determine the different urine flow patterns and active pelvic floor electromyography (EMG) during voiding in children with vesicoureteral reflux (VUR) as well as presenting the prevalence of lower urinary tract symptoms in these patients. MATERIALS AND METHODS: We retrospectively reviewed the charts of children diagnosed with VUR after toilet training from Sep 2013 to Jan 2016. 225 anatomically and neurologically normal children were included. The reflux was diagnosed with voiding cystourethrography...
September 25, 2018: International Braz J Urol: Official Journal of the Brazilian Society of Urology
Houcine Maghrebi, Amine Makni, Rami Rhaeim, Alia Zehani, Anis Haddad, Amine Daghfous, Wael Rebai, Mohamed Jouini, Montasser Kacem, Zoubeir Ben Safta
Sclerosing encapsulating peritonitis (SEP) is a rare and little known pathological entity. It is a chronic fibro-inflammatory disease of the peritoneum, resulting in the formation of a thick fibrous membrane, which engages partially or totally the abdominal organs. Clinical and radiological signs make the diagnosis difficult to establish preoperatively. We present two original observations of SEP illustrating different clinical presentations, diagnostic and therapeutic means. His diagnosis requires a peritoneal biopsy...
January 2018: La Tunisie Médicale
Tommaso Cai, Fabrizio Palumbo, Giovanni Liguori, Nicola Mondaini, Fabrizio Idelfonso Scroppo, Danilo Di Trapani, Andrea Cocci, Alessandro Zucchi, Paolo Verze, Andrea Salonia, Alessandro Palmieri
To investigate the efficacy, tolerability, and patient's preference of alprostadil cream for topical use administered within the urethral meatus versus the standard administration route, in erectile dysfunction (ED) treatment. Seventy-one patients (mean age 59.7 ± 9.0 years) affected by ED were analyzed in this multicenter, randomized, two-administration routes, cross-over trial. All patients received a single dose of alprostadil cream applying the dispenser to the tip of the penis (without contacting the urethral meatus) (Standard administration route or ST...
October 15, 2018: International Journal of Impotence Research
Ricardo M da Costa, Jairo K Bastos, Maria C A Costa, Márcia M C Ferreira, Cássia S Mizuno, Giovanni F Caramori, Gláucio R Nagurniak, Marília R Simão, Raquel A Dos Santos, Rodrigo C S Veneziani, Sérgio R Ambrósio, Renato L T Parreira
In this study, ent-kaurenoic acid derivatives were obtained by microbial transformation methodologies and tested against breast cancer cell lines (MCF-7). A multivariate quantitative-structure activity relationship (QSAR) analysis was performed taking into account both microbial transformation derivatives and other analogues previously reported in literature to give some insight into the main features behind the cytotoxic activity displayed by kaurane-type diterpenes against MCF-7 cells. The partial least square regression (PLS) method was employed in the training set and the best PLS model was built with a factor describing 69...
October 12, 2018: Phytochemistry
Cédric Lenoir, Aleksandar Jankovski, André Mouraux
Recently studies have aimed at developing transcutaneous spinal direct current stimulation (tsDCS) as a non-invasive technique to modulate spinal function in humans. Independent studies evaluating its after-effects on nociceptive or non-nociceptive somatosensory responses have reported comparable effects suggesting that tsDCS impairs axonal conduction of both the spino-thalamic and the medial lemniscus tracts. The present study aimed to better understand how tsDCS affects, in humans, the spinal transmission of nociceptive and non-nociceptive somatosensory inputs...
October 12, 2018: Neuroscience
Emilie Rune Hegelund, Trine Flensborg-Madsen, Ditte Vassard, Janni Niclasen, Erik Lykke Mortensen
The strength of the association between parental socioeconomic position (SEP) and risk of attention-deficit/hyperactivity disorder (ADHD) in offspring is found to vary substantially, perhaps due to the negligence of possible changes in parental life course SEP. The present study investigated the association between parental SEP in adulthood and risk of ADHD diagnosis in offspring and whether parental childhood SEP modified this association. The study population included 9648 live-born singletons followed in the Psychiatric Central Register from birth in 1976-1996 until 2013...
October 11, 2018: European Child & Adolescent Psychiatry
Yazdan Ghandi, Danial Habibi, Elham Farahani
Background: The mitral annular plane systolic excursion (MAPSE) and tricuspid annular plane systolic excursion (TAPSE) are parameters for evaluating systolic function, which is directly affected by ventricular morphology and geometry. Materials and Methods: A cross-sectional study in term and preterm neonates calculated TAPSE and MAPSE at the lateral and septal (LAT/SEP) mitral. The study groups were divided into three classes based on birth age: two preterm groups, 30-33 weeks and 34-37 weeks, and one term group, 38-40 weeks...
July 2018: Journal of Cardiovascular Echography
A B V Furtado, D D Hartmann, R P Martins, P C Rosa, I K da Silva, B S L Duarte, L U Signori, F A A Soares, G O Puntel
When exercises are done in intense or exhaustive modes, several acute biochemical mechanisms are triggered. The use of cryotherapy as cold-water immersion is largely used to accelerate the process of muscular recovery based on its anti-inflammatory and analgesic properties. The present study aimed to study the biochemical effects of cold-water immersion treatment in mice submitted to exercise-induced exhaustion. Swiss albino mice were divided into 4 treatment groups: control, cold-water immersion (CWI), swimming exhaustive protocol (SEP), and SEP+CWI...
October 4, 2018: Brazilian Journal of Medical and Biological Research, Revista Brasileira de Pesquisas Médicas e Biológicas
Valentina Velkoska Nakova, Brankica Krstevska, Elizabeta Srbinovska Kostovska, Olivija Vaskova, Ljubica Georgievska Ismail
OBJECTIVE: Treatment of subclinical hypothyroidism (ScH), especially the mild form of ScH, is controversial because thyroid hormones influence cardiac function. We investigate left ventricular systolic and diastolic function in ScH and evaluate the effect of 5-month levothyroxine treatment. SUBJECTS AND METHODS: Fifty-four patients with newly diagnosed mild ScH (4.2 <TSH < 10.0 mU/L) and 30 euthyroid subjects matched by age were analysed. Laboratory analyses and an echocardiography study were done at the first visit and after 5 months in euthyroid stage in patients with ScH...
August 2018: Archives of Endocrinology and Metabolism
Catherine A Makarewich, Amir Z Munir, Gabriele G Schiattarella, Svetlana Bezprozvannaya, Olga N Raguimova, Ellen E Cho, Alexander H Vidal, Seth L Robia, Rhonda Bassel-Duby, Eric N Olson
Calcium (Ca2+ ) dysregulation is a hallmark of heart failure and is characterized by impaired Ca2+ sequestration into the sarcoplasmic reticulum (SR) by the SR-Ca2+ -ATPase (SERCA). We recently discovered a micropeptide named DWORF (<u>DW</u>arf <u>O</u>pen <u>R</u>eading <u>F</u>rame) that enhances SERCA activity by displacing phospholamban (PLN), a potent SERCA inhibitor. Here we show that DWORF has a higher apparent binding affinity for SERCA than PLN and that DWORF overexpression mitigates the contractile dysfunction associated with PLN overexpression, substantiating its role as a potent activator of SERCA...
October 9, 2018: ELife
Mohd Masood, George Mnatzaganian, Sarah R Baker
OBJECTIVES: To examine any change over time in the association between deprivation and caries experience between 2003 and 2013 in a nationally representative sample of UK children. METHODS: Data from UK Children's Dental Health Surveys, 2003 and 2013, were used. The target population was 5-, 8-, 12- and 15-year-olds. A total of 9604 children in 2003 and 9866 in 2013 were included in the surveys. Outcome variables were any active caries, caries experience and total number of carious teeth...
October 9, 2018: Community Dentistry and Oral Epidemiology
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