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Chika Horikawa, Rei Otsuka, Yuki Kato, Yukiko Nishita, Chikako Tange, Tomohiro Rogi, Hiroshi Kawashima, Hiroshi Shibata, Fujiko Ando, Hiroshi Shimokata
It remains unclear whether n -3 long-chain polyunsaturated fatty acids (LCPUFA) have a preventive effect on depression in the general population. This study investigated the longitudinal association between n -3 LCPUFA intake and depressive symptoms in community-dwelling Japanese participants. The participants were aged 40⁻79 years at baseline in the cohort study; wherein examinations; including the assessment of depressive symptoms and nutritional status; were biennially conducted from 1997 to 2012. The subjects ( n = 2335) who had a Center for Epidemiologic Studies Depression Scale (CES-D) score < 16 at the first examination and who participated in the follow-up study at least once were included in the analysis...
November 3, 2018: Nutrients
Yasue Uchida, Yukiko Nishita, Takashi Kato, Kaori Iwata, Saiko Sugiura, Hirokazu Suzuki, Michihiko Sone, Chikako Tange, Rei Otsuka, Fujiko Ando, Hiroshi Shimokata, Akinori Nakamura
A growing body of literature has demonstrated that dementia and hearing loss are interrelated. Recent interest in dementia research has expanded to brain imaging analyses with auditory function. The aim of this study was to investigate the link between hearing ability, which was assessed using pure-tone audiometry, and the volume of brain regions, specifically the hippocampus, entorhinal cortex, Heschl's gyrus, and total gray matter, using Freesurfer software and T1-weighted brain magnetic resonance imaging...
2018: Frontiers in Aging Neuroscience
Kirat Singh Grewal, Rohit Bhatia, Nishita Singh, Rajesh Singh, Deepa Dash, Manjari Tripathi
We report the case of a pregnant female presenting with behavioral change and hallucinations followed by focal seizures with impaired awareness. EEG revealed generalized slowing interspersed with extreme delta-brush pattern and MRI brain was normal. Both Serum and CSF anti-N-methyl-d-aspartate receptor (NMDAR) antibodies were positive. Patient had a prolonged hospital stay with full recovery and delivered a healthy baby, highlighting the significance of early diagnosis and management in this disorder.
December 15, 2018: Journal of Neuroimmunology
Mohamed H Khalaf, Vandana Sundaram, Mohammed Ahmed AbdelRazek Mohammed, Rajesh Shah, Ankaj Khosla, Katherine Jackson, Manisha Desai, Nishita Kothary
Purpose To develop and validate a predictive model for postembolization syndrome (PES) following transarterial hepatic chemoembolization (TACE) for hepatocellular carcinoma. Materials and Methods In this single-center, retrospective study, 370 patients underwent 513 TACE procedures between October 2014 and September 2016. Seventy percent of the patients were randomly assigned to a training data set and the remaining 30% were assigned to a testing data set. Variables included demographic, laboratory, clinical, and procedural details...
October 9, 2018: Radiology
Yosuke Amaike, Yoshinori Nishita, Kohji Uraguchi, Ryuichi Masuda
To assess the genetic diversity of the red fox (Vulpes vulpes) population on Hokkaido Island, northern Japan, we examined genotypes of exon 2 of the major histocompatibility complex (MHC) class II DRB1 gene for 232 individuals and identified 17 novel alleles. The subpopulation in the Southern area was genetically differentiated from those in all other areas on Hokkaido, suggesting isolation in southern Hokkaido. In addition, the Southern subpopulation is lower in genetic diversity than the other subpopulations, possibly resulting from purifying selection and/or a recent bottleneck...
October 2018: Zoological Science
Nishita Shastri, Yu-Chen Tsai, Suzanne Hile, Deondre Jordan, Barrett Powell, Jessica Chen, Dillon Maloney, Marei Dose, Yancy Lo, Theonie Anastassiadis, Osvaldo Rivera, Taehyong Kim, Sharvin Shah, Piyush Borole, Kanika Asija, Xiang Wang, Kevin D Smith, Darren Finn, Jonathan Schug, Rafael Casellas, Liliya A Yatsunyk, Kristin A Eckert, Eric J Brown
DNA polymerase stalling activates the ATR checkpoint kinase, which in turn suppresses fork collapse and breakage. Herein, we describe use of ATR inhibition (ATRi) as a means to identify genomic sites of problematic DNA replication in murine and human cells. Over 500 high-resolution ATR-dependent sites were ascertained using two distinct methods: replication protein A (RPA)-chromatin immunoprecipitation (ChIP) and breaks identified by TdT labeling (BrITL). The genomic feature most strongly associated with ATR dependence was repetitive DNA that exhibited high structure-forming potential...
October 18, 2018: Molecular Cell
Mohammed A AbdelRazek Mohammed, Mohamed H Khalaf, Tie Liang, David S Wang, Matthew P Lungren, Jarret Rosenberg, Nishita Kothary
PURPOSE: To evaluate validity of albumin-bilirubin (ALBI) grade as a predictor of acute-on-chronic liver failure (ACLF) after transarterial chemoembolization for hepatocellular carcinoma (HCC) in patients with baseline moderate to severe liver dysfunction. MATERIALS AND METHODS: In this retrospective study, serum albumin and bilirubin levels measured before chemoembolization were used to calculate ALBI score in 123 patients treated with 187 high-risk chemoembolizations...
November 2018: Journal of Vascular and Interventional Radiology: JVIR
Nishita Singh, Sucharita Ray, Achal Srivastava
Giving a diagnosis of amyotrophic lateral sclerosis to a patient is akin to handing out a death certificate. However, not all patients presenting with the classical dysphagia, wasting, and weakness may have motor neuron diseases. In these cases, it is extremely important not to miss little cues which can suggest an alternative diagnosis and in many cases a lease of life in terms of a treatment option. In this review, we consider some clinical scenarios that can present with the same symptom complex as diseases involving motor neurons but have a different anatomical or etiopathological basis and in many cases even a therapeutic option...
July 2018: Annals of Indian Academy of Neurology
Muhammad Awais Rehan, Annapurna Kuppa, Abhilasha Ahuja, Shazra Khalid, Nishita Patel, Firman Sandiyah Budi Cardi, Viraj V Joshi, Amna Khalid, Hassaan Tohid
We discuss a strange case of dissociative identity disorder, also known as multiple personality disorder. This article describes the case of a 55-year-old Caucasian woman with a history of substance use disorder with seven personalities. The patient describes a couple of triggers for her condition. More research is needed to understand these triggers.
July 10, 2018: Curēus
Yasue Uchida, Saiko Sugiura, Yukiko Nishita, Naoki Saji, Michihiko Sone, Hiromi Ueda
The amount of attention to age-related hearing loss (ARHL) has been growing, not only from the perspective of being one of the most common health conditions affecting older adults, but also from the perspective of its relation to cognition. Results from a number of epidemiological and laboratory studies have demonstrated a significant link between ARHL and cognitive decline. The Lancet International Commission on Dementia, Prevention, Intervention, and Care has estimated that mid-life hearing loss, if eliminated, might decrease the risk of dementia by nine percent, since hearing loss is a modifiable age-associated condition linked to dementia...
August 31, 2018: Auris, Nasus, Larynx
Atsumu Yuki, Rei Otsuka, Chikako Tange, Yukiko Nishita, Makiko Tomida, Fujiko Ando, Hiroshi Shimokata
AIM: The association between polypharmacy and the development of frailty is unknown. The present study assessed the longitudinal relationship between polypharmacy and frailty risk in Japanese community-dwelling older adults. METHODS: Participants included 299 non-frail older Japanese adults aged 65-81 years who participated in both baseline and follow-up examinations of a longitudinal study of aging (mean duration 6.2 years). At baseline examination, all prescribed and non-prescribed medications used during the previous 2 weeks were confirmed and coded by physicians...
August 30, 2018: Geriatrics & Gerontology International
Mandeep Tomar, Richa Dhiman, Gaurav Sharma, Nishita Yadav
No abstract text is available yet for this article.
July 2018: Journal of Ophthalmic & Vision Research
Toshinori Onishi, Akiko Honda, Michitaka Tanaka, Pratiti H Chowdhury, Hitoshi Okano, Tomoaki Okuda, Daiki Shishido, Yoshihiro Terui, Shuichi Hasegawa, Takayuki Kameda, Susumu Tohno, Masahiko Hayashi, Chiharu Nishita-Hara, Keiichiro Hara, Kozo Inoue, Makoto Yasuda, Shigeru Hirano, Hirohisa Takano
Ambient particulate matter (PM) epidemiologically exacerbates respiratory and immune health, including allergic rhinitis (AR) and bronchial asthma (BA). Although fine and coarse particles can affect respiratory tract, the differences in their effects on the upper and lower respiratory tract and immune system, their underlying mechanism, and the components responsible for the adverse health effects have not been yet completely elucidated. In this study, ambient fine and coarse particles were collected at three different locations in Japan by cyclone technique...
November 2018: Environmental Pollution
Rishika, Nishita Garg, Sandeep Singh Mayall, Lumbini Pathivada, Ramakrishna Yeluri
OBJECTIVE: This manuscript shows if enamel deproteinization along with an intermediate layer of bonding enhances the retention of pit and fissure sealants.. STUDY DESIGN: Two hundred six mandibular first permanent molars were allocated to Group I (n=103) and Group II (n=103). Group I underwent deproteinization, acid etching, bonding agent application and pit & fissure sealant placement while Group II treated with acid etching followed by pit & fissure sealant application only...
2018: Journal of Clinical Pediatric Dentistry
Keishi Kishimoto, Masaru Tamura, Michiru Nishita, Yasuhiro Minami, Akira Yamaoka, Takaya Abe, Mayo Shigeta, Mitsuru Morimoto
Tube morphogenesis is essential for internal-organ development, yet the mechanisms regulating tube shape remain unknown. Here, we show that different mechanisms regulate the length and diameter of the murine trachea. First, we found that trachea development progresses via sequential elongation and expansion processes. This starts with a synchronized radial polarization of smooth muscle (SM) progenitor cells with inward Golgi-apparatus displacement regulates tube elongation, controlled by mesenchymal Wnt5a-Ror2 signaling...
July 19, 2018: Nature Communications
Mark C de Gooijer, Ping Zhang, Levi C M Buil, Ceren H Çitirikkaya, Nishita Thota, Jos H Beijnen, Olaf van Tellingen
Characterization of the genomic landscapes of intracranial tumours has revealed a clear role for the PI3K-AKT-mTOR pathway in tumorigenesis and tumour maintenance of these malignancies, making phosphatidylinositol 3-kinase (PI3K) inhibition a promising therapeutic strategy for these tumours. Buparlisib is a novel pan-PI3K inhibitor that is currently in clinical development for various cancers, including primary and secondary brain tumours. Importantly however, earlier studies have revealed that sufficient brain penetration is a prerequisite for antitumor efficacy against intracranial tumours...
July 17, 2018: Scientific Reports
Maria Victoria Botuyan, Gaofeng Cui, Pascal Drané, Catarina Oliveira, Alexandre Detappe, Marie Eve Brault, Nishita Parnandi, Shweta Chaubey, James R Thompson, Benoît Bragantini, Debiao Zhao, J Ross Chapman, Dipanjan Chowdhury, Georges Mer
Dynamic protein interaction networks such as DNA double-strand break (DSB) signaling are modulated by post-translational modifications. The DNA repair factor 53BP1 is a rare example of a protein whose post-translational modification-binding function can be switched on and off. 53BP1 is recruited to DSBs by recognizing histone lysine methylation within chromatin, an activity directly inhibited by the 53BP1-binding protein TIRR. X-ray crystal structures of TIRR and a designer protein bound to 53BP1 now reveal a unique regulatory mechanism in which an intricate binding area centered on an essential TIRR arginine residue blocks the methylated-chromatin-binding surface of 53BP1...
July 2018: Nature Structural & Molecular Biology
Shamshidin Abduriyim, Yoshinori Nishita, Pavel A Kosintsev, Evgeniy Raichev, Risto Väinölä, Alexey P Kryukov, Alexei V Abramov, Yayoi Kaneko, Ryuichi Masuda
Because of their role in immune defense against pathogens, major histocompatibility complex (MHC) genes are useful in evolutionary studies on how wild vertebrates adapt to their environments. We investigated the molecular evolution of MHC class I (MHCI) genes in four closely related species of Eurasian badgers, genus Meles. All four species of badgers showed similarly high variation in MHCI sequences compared to other Carnivora. We identified 7-21 putatively functional MHCI sequences in each of the badger species, and 2-7 sequences per individual, indicating the existence of 1-4 loci...
June 29, 2018: Heredity
Mohammed Ahmed Abdelrazek Mohammed, Mohamed H Khalaf, Andrew Kesselman, David S Wang, Nishita Kothary
Current imaging technologies are capable of acquiring volumetric data, but they are limited by the flat 2-dimensional representation of complex 3-dimensional data. This pictorial report illustrates the potential role of interactive virtual reality (VR) that enables physicians to visualize and interact with image data as if they were real physical objects. Increasing availability of tools that make the VR environment a possibility could potentially be valuable in the interventional radiology suite.
July 2018: Journal of Vascular and Interventional Radiology: JVIR
Takeshi Saji, Michiru Nishita, Hiroyuki Ogawa, Takefumi Doi, Yasuhiro Sakai, Yoshimasa Maniwa, Yasuhiro Minami
Malignant pleural mesothelioma (MPM) is a highly aggressive tumor with poor prognosis and closely related to exposure to asbestos. MPM is a heterogeneous tumor with three main histological subtypes, epithelioid, sarcomatoid, and biphasic types, among which sarcomatoid type shows the poorest prognosis. The Ror-family of receptor tyrosine kinases, Ror1 and Ror2, is expressed in various types of tumor cells at higher levels and affects their aggressiveness. However, it is currently unknown whether they are expressed in and involved in aggressiveness of MPM...
July 2018: Genes to Cells: Devoted to Molecular & Cellular Mechanisms
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