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P R Pugh, C W Dunn, S H D Haddock
A new species of calycophoran siphonophore, Tottonophyes enigmatica gen. nov, sp. nov., is described. It has a unique combination of traits, some shared with prayomorphs (including two rounded nectophores) and some with clausophyid diphyomorphs (the nectophores are dissimilar, with one slightly larger and slightly to the anterior of the other, and both possess a somatocyst). Molecular phylogenetic analyses indicate that the new species is the sister group to all other diphyomorphs. A new family, Tottonophyidae, is established for it...
May 1, 2018: Zootaxa
Richard R Suminski, Walker S C Poston, R Sue Day, Nattinee Jitnarin, C Keith Haddock, Sara A Jahnke, Gregory M Dominick
OBJECTIVES: To establish the extent of steady state hypohydration among firefighters and examine factors associated with their hydration status. METHODS: Data on 450 career firefighters from 11 randomly selected fire departments had their body composition, total body water (TBW), and hypohydration status assessed using bioelectrical impedance. Measured height and weight were used to determine body mass index (BMI) and weight classification. RESULTS: The hypohydration rate was 17% and 94% of hypohydrated firefighters were obese...
October 10, 2018: Journal of Occupational and Environmental Medicine
Laith A Jawad, Tom J Hansen, Sonnich Meier, Jon Egil Skjaeraasen, Per Gunnar Fjelldal
This study describes radiological malformations in the vertebral column of adult sexually mature wild haddock, Melanogrammus aeglefinus collected from Masfjorden, Western Norway, in 2014 and 2015. There were seven deformed fish (33% of sampled fish), five with mild deformities and two with severe deformities. The deformity types discovered were lordosis, vertebra body asymmetry, compression, fusion (ankylosis), remodelling, and haemal spine hyperostosis. The two severely deformed fish were as follows: (a) one specimen with 29 deformed vertebrae within the region vertebrae nos...
October 7, 2018: Journal of Fish Diseases
David M Routman, Ryan K Funk, Bradley J Stish, Lance A Mynderse, Torrence M Wilson, Robert McLaren, W Scott Harmsen, Kristin Mara, Christopher L Deufel, Keith M Furutani, Michael G Haddock, Thomas M Pisansky, C Richard Choo, Brian J Davis
PURPOSE: To report outcomes of patients undergoing low-dose-rate (LDR) brachytherapy and investigate factors associated with biochemical failure and survival. METHODS: Consecutive patients undergoing LDR with I-125 at our institution between 1998 through 2013 for primary intact prostate cancer were examined. Those with low- and intermediate-risk disease receiving LDR with a minimum of 2 years followup and at least one post-LDR prostate-specific antigen (PSA) were included...
October 4, 2018: Brachytherapy
Sneha Rai, Pallavi Mohanty, Sonika Bhatnagar
PH domains mediate interactions involved in cell signaling, intracellular membrane transport regulation and cytoskeleton organization. Some PH domains bind phosphoinositides with different affinity and specificity. The two novel PLCη (1 and 2) possess an N-terminal PH domain (PHη1 and PHη2 respectively) that has been implicated in membrane association and induction of PLC activity. Understanding of the structure and dynamics is crucial for future modulation of lipid-protein interactions in PHη1, PHη2 and other PH domains...
August 29, 2018: Journal of Molecular Graphics & Modelling
Leslie S Babonis, Melissa B DeBiasse, Warren R Francis, Lynne M Christianson, Anthony G Moss, Steven H D Haddock, Mark Q Martindale, Joseph F Ryan
The origin of novel traits can promote expansion into new niches and drive speciation. Ctenophores (comb jellies) are unified by their possession of a novel cell type: the colloblast, an adhesive cell found only in the tentacles. Although colloblast-laden tentacles are fundamental for prey capture among ctenophores, some species have tentacles lacking colloblasts and others have lost their tentacles completely. We used transcriptomes from 36 ctenophore species to identify gene losses that occurred specifically in lineages lacking colloblasts and tentacles...
August 30, 2018: Molecular Biology and Evolution
Panagiotis I Koukos, Li C Xue, Alexandre M J J Bonvin
We report the performance of HADDOCK in the 2018 iteration of the Grand Challenge organised by the D3R consortium. Building on the findings of our participation in last year's challenge, we significantly improved our pose prediction protocol which resulted in a mean RMSD for the top scoring pose of 3.04 and 2.67 Å for the cross-docking and self-docking experiments respectively, which corresponds to an overall success rate of 63% and 71% when considering the top1 and top5 models respectively. This performance ranks HADDOCK as the 6th and 3rd best performing group (excluding multiple submissions from a same group) out of a total of 44 and 47 submissions respectively...
August 20, 2018: Journal of Computer-aided Molecular Design
Min Zhu, Xiuchang Ma, Yongxiang Gao, Xiaowu Li, Jiyuan Ke, Muhammad Hidayatullah Khan, Maikun Teng, Honghua Ge, Zhongliang Zhu, Liwen Niu
By bearing a papain-like core structure and a cysteine-based catalytic triad, deamidase can convert glutamine to glutamic acid or asparagine to aspartic acid to modify the functions of host target proteins resulting in the blocking of eukaryotic host cell function. Legionella pneumophila effector Lpg2148 (MvcA) is a deamidase, a structural homolog of cycle inhibiting factor (Cif) effectors. Lpg2148 and Cif effectors are functionally diverse, with Lpg2148 only catalyzing ubiquitin but not NEDD8. However, a detailed understanding of substrate specificity is still missing...
September 18, 2018: Biochemical and Biophysical Research Communications
Elham Jafari, Ali Gheysarzadeh, Karim Mahnam, Rezvan Shahmohammadi, Amir Ansari, Hadi Bakhtyari, Mohammad Reza Mofid
Insulin-like growth factor binding protein-3 (IGFBP-3) is a vital protein exist in circulation which interacts with high affinity to insulin-like growth factor (IGFs) altering their activities. Therefore, the interaction between IGFs and IGFBP-3 has a key role altering large spectrum of activities such as cell cycle progression, proliferation and apoptosis. Despite decades of research, the crystal structure of IGFBP-3 has not been identified possibly due to some technical challenge in its crystallizing. The three-dimensional (3D) structure of IGFBP-3 was predicted using homology modeling, Phyre2, and molecular dynamic...
August 2018: Research in Pharmaceutical Sciences
Sumeet S Teotia, Nicholas T Haddock
No abstract text is available yet for this article.
October 2018: Plastic and Reconstructive Surgery
Andrew Haddock, Kyle T Mitchell, Andrew Miller, Jill L Ostrem, Howard J Chizeck, Svjetlana Miocinovic
Deep brain stimulation (DBS) programming, the systematic selection of fixed electrical stimulation parameters that deliver maximal therapeutic benefit while limiting side effects, poses several challenges in the treatment of movement disorders. DBS programming requires the expertise of trained neurologists or nurses who assess patient symptoms according to standardized clinical rating scales and use patient reports of DBS-related side effects to adjust stimulation parameters and optimize therapy. In this paper, we describe and validate an automated software platform for DBS programming for tremor associated with Parkinson's disease and essential tremor...
August 2018: IEEE Transactions on Neural Systems and Rehabilitation Engineering
Min-Jeong Cho, Nicholas T Haddock, Andrew A Gassman, Sumeet S Teotia
The success of microvascular reconstruction depends on many factors. Although many factors cannot be dictated by a surgeon, the success of anastomosis can be maximized by honing skill with performing anastomoses. However, size discrepancy of vessels remains a common challenge, given the lack of an ideal technique. In this study, the authors introduce their experience in using composite deep inferior epigastric arterial and venous grafts to overcome the vessel size and pedicle length discrepancy in lateral thigh and superficial inferior epigastric artery (SIEA) flaps...
October 2018: Plastic and Reconstructive Surgery
D T Schultz, A A Kotlobay, R Ziganshin, A Bannikov, N M Markina, T V Chepurnyh, E S Shakhova, K Palkina, S H D Haddock, I V Yampolsky, Y Oba
No abstract text is available yet for this article.
September 5, 2018: Biochemical and Biophysical Research Communications
Zsuzsanna Orbán-Németh, Rebecca Beveridge, David M Hollenstein, Evelyn Rampler, Thomas Stranzl, Otto Hudecz, Johannes Doblmann, Peter Schlögelhofer, Karl Mechtler
In the version of this article initially published online, the authors used incorrectly defined restraints for specifying the distance between residues when using the HADDOCK portal. Following the publication of a Correspondence by the developers of the HADDOCK portal (Nat. Protoc., 2018) and a Reply by the authors of the Protocol (Nat. Protoc., 2018), the syntax in step 21 has been corrected. In addition, the input files (available as Supplementary Data 5-7) have been replaced...
July 2018: Nature Protocols
Catriona Munro, Stefan Siebert, Felipe Zapata, Mark Howison, Alejandro Damian-Serrano, Samuel H Church, Freya E Goetz, Philip R Pugh, Steven H D Haddock, Casey W Dunn
Siphonophores are a diverse group of hydrozoans (Cnidaria) that are found at most depths of the ocean - from the surface, like the familiar Portuguese man of war, to the deep sea. They play important roles in ocean ecosystems, and are among the most abundant gelatinous predators. A previous phylogenetic study based on two ribosomal RNA genes provided insight into the internal relationships between major siphonophore groups. There was, however, little support for many deep relationships within the clade Codonophora...
October 2018: Molecular Phylogenetics and Evolution
David W Hawman, Elaine Haddock, Kimberly Meade-White, Brandi Williamson, Patrick W Hanley, Kyle Rosenke, Takashi Komeno, Yousuke Furuta, Brian B Gowen, Heinz Feldmann
Crimean-Congo hemorrhagic fever virus (CCHFV) is a cause of serious hemorrhagic disease in humans. Humans infected with CCHFV develop a non-specific febrile illness and then progress to the hemorrhagic phase where case fatality rates can be as high as 30%. Currently there is lack of vaccines and the recommended antiviral treatment, ribavirin, has inconsistent efficacy in both human and animal studies. In this study we developed a model of CCHFV infection in type I interferon deficient mice using the clinical CCHFV isolate strain Hoti...
September 2018: Antiviral Research
Lauren M Stein, Christopher J Haddock, Willis K Samson, Grant R Kolar, Gina L C Yosten
Using a series of classical protein purification techniques, coupled with more modern molecular approaches, a family of neuropeptides, the Phoenixins, was identified to be produced in brain and heart, and to bind selectively in pituitary gland, ovary and brain. These same binding sites were revealed, using a novel receptor identification strategy, to express the orphan G protein-coupled receptor, GPR173, the expression of which was required for the actions of phoenixin both in vivo and in vitro. In fact, studies using small interfering RNA molecules to compromise GPR173 expression revealed the physiologic relevance of the initially reported pharmacologic actions of the peptides...
August 2018: Peptides
Jacob Beal, Traci Haddock-Angelli, Geoff Baldwin, Markus Gershater, Ari Dwijayanti, Marko Storch, Kim de Mora, Meagan Lizarazo, Randy Rettberg
Fluorescent reporters are commonly used to quantify activities or properties of both natural and engineered cells. Fluorescence is still typically reported only in arbitrary or normalized units, however, rather than in units defined using an independent calibrant, which is problematic for scientific reproducibility and even more so when it comes to effective engineering. In this paper, we report an interlaboratory study showing that simple, low-cost unit calibration protocols can remedy this situation, producing comparable units and dramatic improvements in precision over both arbitrary and normalized units...
2018: PloS One
Emma B Holliday, Scott C Lester, W Scott Harmsen, Cathy Eng, Michael G Haddock, Sunil Krishnan, Prajnan Das, Christopher L Hallemeier
PURPOSE: To report cancer control rates and adverse events (AEs) of curative-intent, extended-field chemoradiation therapy administered to patients with squamous cell carcinoma (SCC) of the anal canal presenting with distant metastasis limited to the para-aortic (PA) lymph nodes. METHODS: This was a retrospective review of patients with SCC of the anal canal metastatic to the PA lymph nodes at initial diagnosis who were treated with curative-intent, extended-field chemoradiation therapy between September 2002 and February 2016 at two tertiary care centers...
September 1, 2018: International Journal of Radiation Oncology, Biology, Physics
William F Regine, Kathryn Winter, Ross A Abrams, Howard Safran, Ivan L Kessel, Yuhchyau Chen, James A Fugazzi, Eric D Donnelly, Thomas A DiPetrillo, Samir Narayan, John P Plastaras, Rakesh Gaur, Guila Delouya, John H Suh, Joshua E Meyer, Michael G Haddock, Mukund S Didolkar, Gilbert D A Padula, David Johnson, John P Hoffman, Christopher H Crane
Purpose: NRG Oncology RTOG 9704 was the first adjuvant trial to validate the prognostic value of postresection CA19-9 levels for survival in patients with pancreatic carcinoma. The data resulting from this study also provide information about predictors of recurrence that may be used to tailor individualized management in this disease setting. This secondary analysis assessed the prognostic value of postresection CA19-9 and surgical margin status (SMS) in predicting patterns of disease recurrence...
April 2018: Advances in Radiation Oncology
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