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Gynecological pathology

Emily R Rosen, David M Kushner, Aparna M Mahajan, Cara R King
Background: Various ovarian neoplasms may show histological findings that are morphologically indistinguishable from adult granulosa cell tumor (AGCT). Case presentation: A 36 year-old women presented with left lower extremity pain and numbness. Ultrasound revealed a 10 cm left adnexal mass treated with ovarian cystectomy. Histopathology revealed endometriotic cyst with intramural granulosa cell tumor. She underwent a laparoscopic left salpingo-oophorectomy and omental biopsy by Gynecologic Oncology...
February 2019: Gynecologic Oncology Reports
Vincent Wagner, Heather Winn, Andreea Newtson, David Bender, Megan McDonald
When elevated serum hCG is discovered during the work up of a gynecologic tumor, it is paramount to identify the source of hCG prior to initiation of treatment. Potential sources of hCG include viable intrauterine pregnancy, ectopic pregnancy, miscarriage, gestational trophoblastic disease, pituitary hCG production, phantom hCG (heterophilic antibody interference), and tumor production. Here, we present a case of elevated hCG in a young women with a large complex pelvic mass. Prior to treatment initiation, the patient underwent work up for hCG elevation, which was ultimately found to be from tumor production...
November 2018: Gynecologic Oncology Reports
Ci Huang, Mun-Kun Hong, Tang-Yuan Chu, Dah-Ching Ding
Background: Adnexal torsion is a gynecologic emergency that requires surgical treatment. In this study, we reviewed the surgical outcomes of women with adnexal torsion in eastern Taiwan (Hualien county, area 4,629 km2 , 330,000 residents). Methods: This retrospective study included 42 women diagnosed with surgically-proven adnexal torsion from January 1, 2010, to September 31, 2015. We compared the symptoms, objective findings, and surgical outcomes of patients who underwent laparotomy or laparoscopy...
2018: PeerJ
David G Deckey, Daniel B C Reid, Scott Mallozzi, Alan H Daniels
BACKGROUND: Cervical squamous cell carcinoma is the second most common cancer in women worldwide, and the third most common cause of female cancer mortality. It frequently metastasizes to the osseous spine and has been rarely reported to cause cutaneous metastases at gynecological surgical scars. CASE DESCRIPTION: A 63-year-old woman with known metastatic cervical squamous cell carcinoma presented with a pathologic fracture of the L2 vertebra, unrelenting back pain, bilateral lower extremity weakness, and inability to ambulate...
December 5, 2018: World Neurosurgery
Hae Lee Joo, Yu Ri Shin, Sung Eun Rha, Chang Suk Park, Dong Jae Shim, Kijun Kim
OBJECTIVES: Clear cell carcinoma (CCC) of the ovary shows distinct clinical characteristics depending on the stage. We aimed to investigate the imaging predictability for tumour stage in CCC. PATIENTS AND METHODS: Fifty-six tumours in 48 patients with pathologically proven CCC were enrolled. CCCs were divided into early and advanced stage based on the International Federation of Gynecology and Obstetrics staging. Two reviewers assessed diverse computed tomography (CT) and magnetic resonance imaging (MRI) findings associated with CCC: laterality, size, margin, cystic component features (internal architecture, CT attenuation, and T1 signal intensity of MRI), solid component features (amount, shape, growth pattern, signal intensity, enhancement pattern, and diffusion restriction), and secondary manifestations (ascites, endometriosis, and venous thromboembolism)...
December 2018: European Journal of Radiology
H L Song, L J Jiang, L Z Jiang, W W Zhang, X Wang, Z H Yan
Objective: To investigate the diagnostic value of MRI for placenta previa complicated with placenta accreta or not. Methods: A total of 220 placenta previa patients were diagnosed by prenatal ultrasound and MRI in The Second Affiliated Hospital of Wenzhou Medical University from May 2014 to May 2017.The MRI images of 220 placenta previa patients suspicious of placenta previa were interpreted by two radiologists who majored on gynecological radiology. The sensitivity, specificity, accuracy, positive predictive value and negative predictive value of two radiologists in diagnosis of placenta accreta were calculated respectively...
December 4, 2018: Zhonghua Yi Xue za Zhi [Chinese medical journal]
Anis Cerovac, Dzenita Ljuca, Enida Nevacinovic, Azur Tulumovic, Ermina Iljazovic
Introduction: Malignant ovarian germ cell tumors (MOGCTs) account for 2-5% of all ovarian cancers and among them pure embryonal cell cancer is rare condition (1, 2, 3, 4). Aim: To show successful pregnancy after unilateral salpingooopherectomy and chemotherapy in a girl with embryonal carcinoma of ovary (ECO). Case report: Patient had FIGO stage III c disease. After the surgical removal of the tumour, the patient underwent six cycles of adjuvant chemotherapy with bleomycin, etoposide and cisplatin (BEP)...
November 2018: Medical Archives
Sawanya Benchahong, Athita Chanthasenanont, Densak Pongrojpaw, Junya Pattaraarchachai, Kornkarn Bhamarapravatana, Komsun Suwannarurk
Abnormal uterine bleeding in women aged 35 years or over is an important clinical sign of many gynecological conditions. The diagnoses of these conditions require the pathological report of the endometrial tissue. Outpatient-based endometrial biopsy is an excellent option compared to standard fractional uterine curettage or hysteroscopy with endometrial biopsy in providing a definite diagnosis for abnormal uterine bleeding as it is less painful and does not require high potency anesthesia. This study evaluates the effect of intrauterine lidocaine on the patient's pain score during endometrial biopsy by the Novak curette...
2018: Pain Research and Treatment
Maria Inês Raposo, Catarina Meireles, Mariana Cardoso, Mariana Ormonde, Cristina Ramalho, Mónica Pires, Mariana Afonso, Almerinda Petiz
Benign Metastasizing Leiomyoma (BML) is a rare condition with few cases reported in the literature. It is usually incidentally diagnosed several years after a primary gynecological surgery for uterine leiomyoma. Differential diagnosis of BML is complex requiring an extensive work-up and exclusion of malignancy. Here, we report two cases of BML based on similarity of histopathological, immunohistochemical, and genetic patterns between lung nodules and uterine leiomyoma previously resected, evidencing the variability of clinical and radiological features of BML...
2018: Case Reports in Obstetrics and Gynecology
Brigitte M Ronnett
CONTEXT.—: Distinction of hydatidiform moles from nonmolar specimens and subclassification of hydatidiform moles as complete hydatidiform mole versus partial hydatidiform mole are important for clinical practice and investigational studies. Risk of persistent gestational trophoblastic disease and clinical management differ for these entities. Diagnosis based on morphology is subject to interobserver variability and remains problematic, even for experienced gynecologic pathologists. OBJECTIVES...
December 2018: Archives of Pathology & Laboratory Medicine
Pei Hui, Lanjing Zhang
No abstract text is available yet for this article.
December 2018: Archives of Pathology & Laboratory Medicine
Gabriele Filip, Alessandro Balzano, Angelo Cagnacci
BACKGROUND: The objective of this study is to evaluate the prevalence of adenomyosis, leiomyomas and of their concomitance in women who underwent hysterectomy. METHODS: An observational study carried out on a cohort of 347 women who underwent hysterectomy from a sample of 2383 patients who had gynecological surgery for benign disease in a single University Hospital between 2013 and 2016. An histological evaluation of all surgical specimens was carried out for the presence of adenomyosis and leiomyomas...
November 27, 2018: Minerva Ginecologica
Anahita Nosrati, Eissa Soleymani, Lotfollah Davoodi
Echinococcus granulosus has been described as the common etiology of hydatid cysts in many parts of the world. A 54-yr-old female with lower abdominal pain referred to Gynecology Ward of Sari Imam Khomeini Hospital, Iran in 2016. Sonography was carried out and cysts in ovaries and liver were observed. The cysts of liver seemed to be hydatidosis but physicians were suspected about ovarian cystic mass. Anti- Echinococcus antibodies (ELISA) screen was positive. The operation was done on her and treatment by albendazole started one week before surgery and continued after discharge from the hospital...
July 2018: Iranian Journal of Parasitology
Nobuko Yasutake, Hirotsugu Noguchi, Yuta Ibayashi, Hiroaki Nakamura, Kazuki Tateishi, Kotaro Yuki, Ryuji Shiina, Shohei Shimajiri, Takuji Fujita
Introduction: Malignant struma ovarii is a rare neoplasm. It is usually asymptomatic and not commonly diagnosed preoperatively. In addition, there is currently no established diagnostic and therapeutic approach for malignant struma ovarii. Case Report: A 66-year-old asymptomatic female was referred to our hospital. Computed tomography showed the presence of a well-defined mass with enhancement in the internal and peripheral areas. The patient underwent total abdominal hysterectomy, bilateral salpingo-oophorectomy, and partial omentectomy...
September 2018: Case Reports in Oncology
Kenta Takahashi, Mayu Yunokawa, Shinsuke Sasada, Yae Takehara, Naoyuki Miyasaka, Tomoyasu Kato, Kenji Tamura
OBJECTIVE: To develop and validate a 3-year recurrence prediction score (RPS) system for predicting the baseline risk of recurrence of stage I-II endometrial carcinoma. METHODS: We reviewed 427 patients with International Federation of Gynecology and Obstetrics staging I-II endometrial carcinoma underwent surgery without any adjuvant therapy from 2005 to 2013. The patients were divided into 2 groups: the test cohort (n=251) comprising those who underwent surgery in odd-numbered years, and the validation cohort (n=176) comprising those who underwent surgery in even-numbered years...
October 2, 2018: Journal of Gynecologic Oncology
Qing Wang, Raul Rodriguez, Jenna Z Marcus, Lisa Podolsky, Damali Campbell, Debra Heller
Primary lymphoma of the ovary, particularly in an HIV-positive woman, is exceptionally rare, and ovarian lymphoma may not be considered at the time of intraoperative consultation. In this article, we present a case in an HIV-positive woman thought to be a dysgerminoma at the time of frozen section, but which was found to be a diffuse large B-cell lymphoma of the ovary.
November 25, 2018: International Journal of Surgical Pathology
Alison G Cahill, Richard Beigi, R Phillips Heine, Robert M Silver, Joseph R Wax
Placenta accreta spectrum, formerly known as morbidly adherent placenta, refers to the range of pathologic adherence of the placenta, including placenta increta, placenta percreta, and placenta accreta. The most favored hypothesis regarding the etiology of placenta accreta spectrum is that a defect of the endometrial-myometrial interface leads to a failure of normal decidualization in the area of a uterine scar, which allows abnormally deep placental anchoring villi and trophoblast infiltration. Maternal morbidity and mortality can occur because of severe and sometimes life-threatening hemorrhage, which often requires blood transfusion...
December 2018: American Journal of Obstetrics and Gynecology
Benjamin L Taylor, Cathleen E Matrai, Ariana L Smith, Abimbola Ayangbesan, Leilei Xia, David M Golombos, Juan Miguel Mosquera, Joseph Nicolas, Brian D Robinson, Douglas S Scherr, Francesca Khani
PURPOSE: To determine a subset of women who could undergo ovary-sparing radical cystectomy (OSRC) for bladder cancer without compromising oncologic safety. PATIENTS AND METHODS: A retrospective review was performed of 164 consecutive women who underwent cystectomy at a single tertiary-care center from 1997 to 2018. Clinicopathologic and preoperative radiographic data were reviewed. Univariable and multivariable logistic regression models adjusting for pathologic stage, lymphovascular invasion (LVI), and carcinomain-situ were performed to evaluate the risk of ovarian and reproductive organ (RO) involvement...
October 29, 2018: Clinical Genitourinary Cancer
T Zou, P-L Wang, Y Gao, W-T Liang
OBJECTIVE: Circular RNAs (circRNAs) have been identified as important regulators in regulating cancer progression. The study aims to investigate the expression of circular RNA_LARP4 (circ LARP4) and clinical significance in ovarian cancer (OC). PATIENTS AND METHODS: The expression of circ LARP4 was detected in a total of 78 paired ovarian cancer tissue and adjacent normal tissue samples using quantitative Reverse Transcription-Polymerase Chain Reaction (qRT-PCR) analyses...
November 2018: European Review for Medical and Pharmacological Sciences
Vijayalakshmi Padmanabhan, Güliz A Barkan, Laura Tabatabai, Rhona Souers, Ritu Nayar, Barbara A Crothers
BACKGROUND: Intra-procedural assessment of touch imprint (TI) cytology from needle core biopsies (NCB) is used to ensure sample adequacy and to provide immediate diagnosis in various settings. We aimed to survey laboratories for current practices on the use of cytology with NCB. METHODS: A voluntary supplemental questionnaire including questions on demographics, personnel involved, sites, accessioning, and reporting was sent with the College of American Pathologists (CAP) 2015 Non gynecologic Cytopathology Education Program to survey practices of cytologic assessment of NCB...
November 23, 2018: Diagnostic Cytopathology
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