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Pukhraj Rishi, Subramanian Krishnakumar, Jyotirmay Biswas, Sridevi Nair
Purpose: To report bilateral retinoblastoma in an 11-year-old child presenting with floaters and sub-internal limiting membrane (sub-ILM) seeds. Method: An 11-year-old child presented with floaters of 4 months' duration. Examination revealed circumscribed, whitish, subhyaloid, floccular nodules in the juxtapapillary region of both eyes. No solid tumor was seen. Swept-source optical coherence tomography revealed moderately reflective echoes in the sub-ILM space. Vitreous aspiration of sub-ILM deposits and cytopathological examination revealed retinoblastoma...
September 2018: Ocular Oncology and Pathology
Sunil Kumar Yadav, Ella Maria Kadas, Seyedamirhosein Motamedi, Konrad Polthier, Frank Haußer, Kay Gawlik, Friedemann Paul, Alexander Brandt
We present a method for optic nerve head (ONH) 3-D shape analysis from retinal optical coherence tomography (OCT). The possibility to noninvasively acquire in vivo high-resolution 3-D volumes of the ONH using spectral domain OCT drives the need to develop tools that quantify the shape of this structure and extract information for clinical applications. The presented method automatically generates a 3-D ONH model and then allows the computation of several 3-D parameters describing the ONH. The method starts with a high-resolution OCT volume scan as input...
October 2018: Journal of Biomedical Optics
Tajalli Ilm Chandel, Nida Zaidi, Masihuz Zaman, Ishrat Jahan, Aiman Masroor, Ibrar Ahmad Siddique, Shahid M Nayeem, Maroof Ali, Vladimir N Uversky, Rizwan Hasan Khan
Protein aggregation have been associated with several human neurodegenerative diseases, such as Parkinson's and Alzheimer's diseases. There are several small molecules that can reduce aggregation of proteins. The present study aimed to test the hypothesis that the application of more than one inhibitor either simultaneously or consecutively may result in more efficient inhibition of protein aggregation. To this end, the anti-amyloidogenic behaviour of benserazide hydrochloride (BH) and levodopa (LD) individually and in combination (BH + LD) was investigated using various biophysical, microscopic, and computational techniques...
October 9, 2018: Biochimica et biophysica acta. Proteins and proteomics
R Bruce Doak, Gabriela Nass Kovacs, Alexander Gorel, Lutz Foucar, Thomas R M Barends, Marie Luise Grünbein, Mario Hilpert, Marco Kloos, Christopher M Roome, Robert L Shoeman, Miriam Stricker, Kensuke Tono, Daehyun You, Kiyoshi Ueda, Darren A Sherrell, Robin L Owen, Ilme Schlichting
Crystallography chips are fixed-target supports consisting of a film (for example Kapton) or wafer (for example silicon) that is processed using semiconductor-microfabrication techniques to yield an array of wells or through-holes in which single microcrystals can be lodged for raster-scan probing. Although relatively expensive to fabricate, chips offer an efficient means of high-throughput sample presentation for serial diffraction data collection at synchrotron or X-ray free-electron laser (XFEL) sources...
October 1, 2018: Acta Crystallographica. Section D, Structural Biology
Sruthi Arepalli, Sunil K Srivastava, Ming Hu, Peter M Kaiser, Neeley Dukles, Jamie L Reese, Justis P Ehlers
PURPOSE: Ellipsoid zone (EZ) and outer retinal integrity are strongly linked to visual prognosis, but quantitative normative data is lacking. This study evaluates the EZ, outer retina, and inner retina in eyes without macular disease across a wide age spectrum. METHODS: An IRB-approved study was performed for eyes without macular pathology undergoing Spectral Domain Optical Coherence Tomography (SD-OCT) scans on the Cirrus HD-OCT system (Carl Zeiss Meditec, Oberkochen, Germany)...
2018: PloS One
Kanupriya Pande, Jeffrey J Donatelli, Erik Malmerberg, Lutz Foucar, Billy K Poon, Markus Sutter, Sabine Botha, Shibom Basu, R Bruce Doak, Katerina Dörner, Sascha W Epp, Lars Englert, Raimund Fromme, Elisabeth Hartmann, Robert Hartmann, Guenter Hauser, Johan Hattne, Ahmad Hosseinizadeh, Stephan Kassemeyer, Lukas Lomb, Sebastian F Carron Montero, Andreas Menzel, Daniel Rolles, Artem Rudenko, Marvin M Seibert, Raymond George Sierra, Peter Schwander, Abbas Ourmazd, Petra Fromme, Nicholas K Sauter, Michael Bogan, John Bozek, Christoph Bostedt, Ilme Schlichting, Cheryl A Kerfeld, Petrus H Zwart
Fluctuation X-ray scattering (FXS) is an emerging experimental technique in which solution scattering data are collected using X-ray exposures below rotational diffusion times, resulting in angularly anisotropic X-ray snapshots that provide several orders of magnitude more information than traditional solution scattering data. Such experiments can be performed using the ultrashort X-ray pulses provided by a free-electron laser source, allowing one to collect a large number of diffraction patterns in a relatively short time...
October 2, 2018: Scientific Data
Yusuke Shiode, Yuki Morizane, Kosuke Takahashi, Shuhei Kimura, Mio Hosokawa, Masayuki Hirano, Shinichiro Doi, Shinji Toshima, Mika Hosogi, Atsushi Fujiwara, Fumio Shiraga
BACKGROUND: We recently reported that lamellar macular hole (LMH) with lamellar hole-associated epiretinal proliferation (LHEP) can be effectively treated by embedding the LHEP into the retinal cleavage to improve foveal contour and visual acuity. Here, we report a case of LMH with LHEP for which we performed embedding of the LHEP combined with internal limiting membrane (ILM) inversion. We then evaluated the effects of this surgery on macular morphology and visual functions. CASE PRESENTATION: A 62-year-old man presented with visual disturbance (20/29) and metamorphopsia in his right eye...
September 24, 2018: BMC Ophthalmology
Jesus H Gonzalez-Cortes, Abel Ramirez Estudillo, Jorge A Sanchez-Ramos, Yunuen Bages-Rousselon, Mariana Fernandez-Mar, Jesus Mohamed-Hamsho
BACKGROUND AND OBJECTIVE: To evaluate anatomical changes of idiopathic macular hole (MH) after internal limiting membrane removal and after passive suction at the hole's borders using microscope-integrated intraoperative optical coherence tomography (iOCT). PATIENTS AND METHODS: Five eyes of five subjects with full-thickness idiopathic MH underwent phacoemulsification, intraocular lens implantation, pars plana vitrectomy, and internal limiting membrane (ILM) removal...
September 1, 2018: Ophthalmic Surgery, Lasers & Imaging Retina
Yodpong Chantarasorn, Jay C Wang, Miin Roh, Dean Eliott
Macular hole associated with high myopia (MH-HM) and macular hole-associated retinal detachment (MH-RD) are two conditions found in eyes with pathologic myopia that often have poor postoperative outcomes. A discrepancy in size between the stretched retina and the posteriorly expanded sclera is a major factor in the pathogenesis. The authors report a case comprising both types of maculopathy, one in each eye. The eye with the MH-HM (right eye) represents the longest axial length ever reported to have successful macular hole closure by any technique...
September 1, 2018: Ophthalmic Surgery, Lasers & Imaging Retina
Ho Ra, Won Ki Lee
BACKGROUND AND OBJECTIVE: To determine the efficacy of a new surgical technique involving use of a contralateral autologous internal limiting membrane (ILM) free flap for closure of a refractory macular hole (MH). PATIENTS AND METHODS: Closure could not be achieved after several MH surgeries in a 72-year-old woman with an epiretinal membrane (ERM) in the right eye and a chronic MH in the left eye. Therefore, the authors performed surgery on the left eye using a contralateral autologous ILM free flap obtained during ERM surgery performed on the right eye...
September 1, 2018: Ophthalmic Surgery, Lasers & Imaging Retina
Tomaso Caporossi, Lucia Finocchio, Francesco Barca, Fabrizio Franco, Ruggero Tartaro, Stanislao Rizzo
To report a case of a serous macular detachment associated with optic pit that did not improve after a previous vitrectomy with internal limiting membrane (ILM) peeling, peripapillary laser, and gas tamponade. The authors performed a lens-sparing 27-gauge pars plana vitrectomy with autologous transplantation of ILM inside the optic nerve pit and gas tamponade. The subretinal fluid gradually resolved and visual acuity improved to 20/20 at the tenth month after surgery. The authors did not observe a recurrence of subretinal fluid during the 14 months of follow-up...
September 1, 2018: Ophthalmic Surgery, Lasers & Imaging Retina
Ho Ra, Won Ki Lee
PURPOSE: The aim of the present study was to evaluate the efficacy of the inverted internal limiting membrane (ILM) flap technique that involved the use of a perfluorocarbon liquid (PFCL) bubble for the selective prevention of indocyanine green (ICG) staining of the parts of the inverted flap in contact with the retinal pigment epithelium for large macular hole (MH) closure. MATERIALS AND METHODS: This retrospective, interventional, comparative study included 26 patients with idiopathic large MHs (minimum diameter, > 400 µm) who underwent vitrectomy using the inverted ILM flap technique with conventional ILM staining with ICG (n = 14, Group 1) or PFCL-mediated selective ILM staining with ICG (n = 12, Group 2)...
September 14, 2018: Current Eye Research
Hiroya Ota, Hiroshi Kunikata, Naoko Aizawa, Toru Nakazawa
PURPOSE: The internal limiting membrane (ILM) is a normal part of the retina, and the outcomes of ILM removal have not been fully investigated. ILM flap inversion is a recently developed technique that increases the success rate of macular hole (MH) surgery. Thus, we compared the anatomical closure rate and visual outcome in patients undergoing microincision vitrectomy surgery (MIVS) with ILM flap inversion or conventional ILM peeling for the treatment of MH. METHODS: The medical records of 90 eyes with MH were reviewed retrospectively...
2018: PloS One
Yuou Yao, Jinfeng Qu, Chongya Dong, Xiaoxin Li, Jianhong Liang, Hong Yin, Lvzhen Huang, Yan Li, Peipei Liu, Chungting Pan, Xue Ding, Dan Song, Srinivas R Sadda, Mingwei Zhao
PURPOSE: To compare the anatomical outcomes of different extents of internal limiting membrane (ILM) peeling in idiopathic macular hole surgery. METHODS: Prospective, parallel-group, randomized clinical trial. A total of 121 eyes of 121 patients with idiopathic macular hole underwent pars plana vitrectomy, and peeling of the ILM with a diameter of two disk diameters (DD) or 4DD based on randomization. The main outcome was the proportion of eyes with complete hole closure at 12 months...
September 5, 2018: Acta Ophthalmologica
Benjamin Erk, Jan P Müller, Cédric Bomme, Rebecca Boll, Günter Brenner, Henry N Chapman, Jonathan Correa, Stefan Düsterer, Siarhei Dziarzhytski, Stefan Eisebitt, Heinz Graafsma, Sören Grunewald, Lars Gumprecht, Robert Hartmann, Günter Hauser, Barbara Keitel, Clemens von Korff Schmising, Marion Kuhlmann, Bastian Manschwetus, Laurent Mercadier, Erland Müller, Christopher Passow, Elke Plönjes, Daniel Ramm, Dimitrios Rompotis, Artem Rudenko, Daniela Rupp, Mario Sauppe, Frank Siewert, Dieter Schlosser, Lothar Strüder, Angad Swiderski, Simone Techert, Kai Tiedtke, Thomas Tilp, Rolf Treusch, Ilme Schlichting, Joachim Ullrich, Robert Moshammer, Thomas Möller, Daniel Rolles
The non-monochromatic beamline BL1 at the FLASH free-electron laser facility at DESY was upgraded with new transport and focusing optics, and a new permanent end-station, CAMP, was installed. This multi-purpose instrument is optimized for electron- and ion-spectroscopy, imaging and pump-probe experiments at free-electron lasers. It can be equipped with various electron- and ion-spectrometers, along with large-area single-photon-counting pnCCD X-ray detectors, thus enabling a wide range of experiments from atomic, molecular, and cluster physics to material and energy science, chemistry and biology...
September 1, 2018: Journal of Synchrotron Radiation
Thomas J van Rijssen, Danial Mohabati, Greet Dijkman, Thomas Theelen, Eiko K de Jong, Elon H C van Dijk, Camiel J F Boon
PURPOSE: To assess parameters on optical coherence tomography (OCT), and their correlation with best-corrected visual acuity (BCVA) in patients with non-resolving central serous chorioretinopathy (CSC). METHODS: For 25 non-resolving CSC patients treated with photodynamic therapy (PDT), the thickness of retinal layers was assessed on the foveal spectral-domain (SD) OCT scan. Evaluated OCT parameters included the central retinal thickness (CRT), defined as the internal limiting membrane (ILM) to ellipsoid zone (EZ) distance, and the second band thickness (SBT), defined as the EZ to hyperreflective subretinal accumulation distance...
2018: PloS One
Zofia Michalewska, Jerzy Nawrocki
BACKGROUND AND OBJECTIVE: Effects of repeat surgery in failed primary full-thickness macular hole (FTMH) closure with the inverted internal limiting membrane (ILM) flap technique. PATIENTS AND METHODS: Retrospective analysis of patients operated with the inverted ILM flap technique. Optical coherence tomography was performed before initial and secondary surgeries and then at up to 12 months post-surgery. RESULTS: During the second surgery, the inverted ILM flap created at the first attempt had returned to its original position, instead of covering the FTMH...
August 1, 2018: Ophthalmic Surgery, Lasers & Imaging Retina
M Maier, S Bohnacker, J Klein, J Klaas, N Feucht, A Nasseri, C P Lohmann
BACKGROUND: In large full thickness macular holes (FTMH) the closure rate after vitrectomy and conventional internal limiting membrane (ILM) peeling is less than 90%. The aim of this study was to examine the visual acuity and anatomical success rate with high-resolution optical coherence tomography (OCT) after transconjunctival sutureless 23-gauge pars plana vitrectomy as well as intraoperative OCT (iOCT) and Brilliant Peel (BP)-assisted ILM peeling using the inverted ILM flap technique in patients with large FTMHs...
August 13, 2018: Der Ophthalmologe: Zeitschrift der Deutschen Ophthalmologischen Gesellschaft
Rishabh C Date, Emmanuel Y Chang, Veeral S Shah
PURPOSE: To present a case of visually significant retinal injury due to internal limiting membrane (ILM) peeling using ILM forceps alone. METHODS: Case report. RESULTS: A 60-year-old woman who underwent ILM peeling for an epiretinal membrane presented with linear central scotomata. Peeling had been initiated and performed with ILM forceps alone, without the use of other surgical instruments. Fundus examination and spectral domain optical coherence tomography imaging confirmed the presence of several discrete areas of inner and outer retinal injury in the macula, which corresponded to her scotomata...
August 2, 2018: Retinal Cases & Brief Reports
Peipei Zhou, Kai Chen, Man Gao, Jingang Qu, Zhanen Zhang, Randy A Dahlgren, Yanyan Li, Wei Liu, Hong Huang, Xuedong Wang
Conventional magnetic effervescent tablet has many drawbacks, such as not practicable for field processing, rapid moisture absorption, and poor tablet storage characteristics. Herein, we developed a novel magnetic effervescent tablet containing ionic liquid microextraction (MET-ILM) for determination of pyrethroids in dairy milk. It contains only Na2 CO3 as an alkali source (no acidic source) in the Fe3 O4 magnetic tablet; the CO2 -forming reaction is initiated in the acidic solution containing the analytes, and thus the prepared tablet can be stored for long time periods without deterioration...
December 1, 2018: Food Chemistry
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