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San-Ni Chen, Chung-May Yang
Purpose: To evaluate logical surgical approaches to closing macular holes in eyes with proliferative diabetic retinopathy with retinal detachment. Methods: Retrospective, interventional case series. Results: 10 eyes in 10 patients were included in this study. The inverted internal limiting membrane (ILM) flap technique was used in 2 eyes, while inverted ILM insertion was used in 5 eyes, and free ILM flaps in 3 eyes. Closed macular holes and retinal reattachment were observed in all eyes...
2018: Journal of Ophthalmology
Ronel Soibam, Parvez Ahmad Bhat, Manabjyoti Barman, Harsha Bhattacharjee, Arsalan Un Nisa
The purpose of this study was to present the surgical outcome in optic disc pit associated maculopathy in a patient who was treated with vitrectomy, internal limiting membrane (ILM) peeling, barrage laser photocoagulation, and silicone oil tamponade. A 21-year-old Indian male was diagnosed with optic disc pit maculopathy in his left eye with a best-corrected visual acuity (BCVA) of 20/200. A 23-gauge pars plana vitrectomy with peeling of ILM was done using brilliant blue dye. After completion of vitrectomy, fluid-air exchange was performed and silicone oil was instilled into eye...
September 2018: Oman Journal of Ophthalmology
Masihuz Zaman, Haaris Ahsan Safdari, Asra Nasir Khan, Syed Mohammad Zakariya, Saima Nusrat, Tajalli Ilm Chandel, Rizwan Hasan Khan
The interaction between drugs and proteins has turned out to be a significant research area in recent years. These interactions offer structural strategy in drug formulations through better medical efficiency. Thus, interaction of a pharmacologically important flavonoid, pinostrobin, with hen egg white lysozyme (HEWL) has been examined using a multitude of spectroscopic techniques including fluorescence spectroscopy, UV-visible spectroscopy, circular dichroism (CD) and dynamic light scattering (DLS) techniques...
November 29, 2018: Journal of Biomolecular Structure & Dynamics
HyunYoung Ha, Jeff P Hamm
Illusory line motion (ILM) refers to perceived motion in a bar when it is presented all at once. Explanations for ILM include low-level visual accounts, visual attention, and object tracking. These explanations tend to arise from studies using different protocols to induce ILM, based on the assumption that the same illusion is being generated. Using real motion in the same and in the opposite direction as the ILM quantifies the illusions from all protocols as the area between response curves for the left- and right-side inducers...
November 28, 2018: Attention, Perception & Psychophysics
Lu Chen, Yantao Wei, Xuezhi Zhou, Zhaotian Zhang, Wei Chi, Li Gong, Xintong Jiang, Shaochong Zhang
Purpose: To investigate alterations in the morphologic, compositional, and biomechanical properties of the internal limiting membrane (ILM) in pathologic myopic foveoschisis (MF) eyes. Methods: ILM specimens were peeled from 61 eyes with MF and 56 eyes with stage III/IV idiopathic macular hole (IMH) as a control. Samples were analyzed for transmission electron microscopy (TEM), scanning electron microscopy, immunofluorescence, Western blotting, and atomic force microscopy...
November 1, 2018: Investigative Ophthalmology & Visual Science
Xu-Ting Hu, Qin-Tuo Pan, Jing-Wei Zheng, Zong-Duan Zhang
PURPOSE: The aim of this study was to determine the effect of the inverted internal limiting membrane (ILM) flap technique on the macular hole (MH) closure and foveal microstructure recovery of patients with highly myopic MH. METHODS: Pars plana vitrectomy and gas tamponade with the inverted ILM flap technique (19 eyes) or with the ILM peeling technique (21 eyes) were performed in patients with highly myopic MH with or without retinal detachment. The rate of MH closure and retinal reattachment, the reconstructive anatomical change of the foveal microstructure and the best-corrected visual acuities (BCVA) of the two groups were compared...
November 23, 2018: British Journal of Ophthalmology
Atul Kumar, Nasiq Hasan, Prateek Kakkar, Vineet Mutha, R Karthikeya, Dheepak Sundar, Raghav Ravani
Purpose: To compare clinical outcomes of patients undergoing macular hole surgery with heads-up three-dimensional (3D) viewing system and conventional microscope. Methods: In all, 50 eyes of 50 patients with stage 3 or 4 macular hole were randomized and macular hole surgery [inverted internal limiting membrane (ILM) flap technique] was performed in 25 eyes using 3D viewing system and 25 eyes using conventional microscope. All surgeries were performed by a single surgeon...
December 2018: Indian Journal of Ophthalmology
Xin-Ying Hu, Huan Liu, Li-Na Wang, Yu-Zhi Ding, Jie Luan
AIM: To evaluate the efficacy and safety of vitrectomy with internal limiting membrane (ILM) peeling for diabetic macular edema (DME). METHODS: The PubMed, Embase, Web of Science, Cochrane, SionMed,, CNKI databases and Wanfang databases, published until Oct. 2017, were searched to identify studies comparing the clinical outcomes following vitrectomy with and without ILM peeling, for treating DME. Pooled results were expressed as odds ratios (ORs) with corresponding 95% confidence intervals (CI) for vitrectomy with and without ILM peeling with regard to best corrected visual acuity (BCVA), central macular thickness (CMT), and complication incidents...
2018: International Journal of Ophthalmology
A-L Jeancolas, P Foveau, B Leroy, J-P Berrod, J-B Conart
PURPOSE: To evaluate the anatomical and functional outcomes of macular hole (MH) surgery with a temporal inverted internal limiting membrane (ILM) flap technique. METHODS: Monocentric retrospective study of 24 patients who were operated on for macular hole between March 2014 and April 2017 at Nancy University Hospital. All patients underwent pars plana vitrectomy with the inverted ILM flap technique. ILM peeling was restricted to the temporal side of the fovea, and the macular hole was then covered with the ILM flap, followed by SF6 tamponnade and first day face-down positioning...
November 12, 2018: Journal Français D'ophtalmologie
Christopher J Creveling, Jourdan Colter, Brittany Coats
While several studies have qualitatively investigated age- and region-dependent adhesion between the vitreous and retina, no studies have directly measured the vitreoretinal strength of adhesion. In this study, we developed a rotational peel device and associated methodology to measure the maximum and steady-state peel forces between the vitreous and the retina. Vitreoretinal adhesion in the equator and posterior pole were measured in human eyes from donors ranging 30 to 79 years of age, and in sheep eyes from premature, neonatal, young lamb, and young adult sheep...
2018: Frontiers in Bioengineering and Biotechnology
María Bové Álvarez, Sergi Sabaté, María Gómez-Resa, José García-Arumí
PURPOSE: To compare the results of vitrectomy with internal limiting membrane (ILM) peeling and inverted ILM flap for treating myopic macular hole without retinal detachment. METHODS: Twenty-eight eyes of 28 patients undergoing vitrectomy with either ILM peeling (n = 16) or inverted ILM flap technique (n = 12) were included. Outcomes were myopic macular hole closure by optical coherence tomography and visual acuity at 6 months and at the end of follow-up. RESULTS: Closure of myopic macular hole was achieved in 13 eyes (81...
October 29, 2018: Retina
Kanupriya Pande, Jeffrey J Donatelli, Erik Malmerberg, Lutz Foucar, Christoph Bostedt, Ilme Schlichting, Petrus H Zwart
Fluctuation X-ray scattering (FXS) is an emerging experimental technique in which X-ray solution scattering data are collected from particles in solution using ultrashort X-ray exposures generated by a free-electron laser (FEL). FXS experiments overcome the low data-to-parameter ratios associated with traditional solution scattering measurements by providing several orders of magnitude more information in the final processed data. Here we demonstrate the practical feasibility of FEL-based FXS on a biological multiple-particle system and describe data-processing techniques required to extract robust FXS data and significantly reduce the required number of snapshots needed by introducing an iterative noise-filtering technique...
November 13, 2018: Proceedings of the National Academy of Sciences of the United States of America
Jie Ma, Timothy J Bruce, Ponnerassery S Sudheesh, Christopher Knupp, Thomas P Loch, Mohamed Faisal, Kenneth D Cain
Bacterial coldwater disease, caused by Flavobacterium psychrophilum, remains one of the most significant bacterial diseases of salmonids worldwide. A previously developed and reported live-attenuated immersion vaccine (F. psychrophilum; B.17-ILM) has been shown to confer significant protection to salmonids. To further characterize this vaccine, a series of experiments were carried out to determine the cross-protective efficacy of this B.17-ILM vaccine against 9 F. psychrophilum isolates (representing seven sequence types/three clonal complexes as determined by multilocus sequence typing) in comparison with a wild-type virulent strain, CSF-259-93...
October 28, 2018: Journal of Fish Diseases
Arunava Chakravarty, Jayanthi Sivaswamy
BACKGROUND AND OBJECTIVE: Accurate segmentation of the intra-retinal tissue layers in Optical Coherence Tomography (OCT) images plays an important role in the diagnosis and treatment of ocular diseases such as Age-Related Macular Degeneration (AMD) and Diabetic Macular Edema (DME). The existing energy minimization based methods employ multiple, manually handcrafted cost terms and often fail in the presence of pathologies. In this work, we eliminate the need to handcraft the energy by learning it from training images in an end-to-end manner...
October 2018: Computer Methods and Programs in Biomedicine
Josef Guber, Max Vieregge, Hendrik P N Scholl, Christophe Valmaggia
PURPOSE: To evaluate the technique and the long-term outcomes after autologous internal limiting membrane flap surgery for refractory macular holes. METHODS: The free ILM flap technique was used as a secondary procedure for non-closing macular holes after failed initial standard procedure. SD-OCT images were taken to assess the anatomical outcome of surgery while best corrected visual acuity (BCVA) was used to evaluate the functional outcome during a one-year follow-up...
October 16, 2018: Klinische Monatsblätter Für Augenheilkunde
Andrew M Vahabzadeh-Hagh, Pranati Pillutla, Zhaoyan Zhang, Dinesh K Chhetri
OBJECTIVES: Laryngeal function requires neuromuscular activation of the intrinsic laryngeal muscles (ILMs). Rapid activation of the ILMs occurs in cough, laughter, and voice-unvoiced-voiced segments in speech and singing. Abnormal activation is observed in hyperfunctional disorders such as vocal tremor and dystonia. In this study, we evaluate the dynamics of ILM contraction. STUDY/DESIGN: Basic science study in an in vivo canine model. METHODS: The following ILMs were stimulated: thyroarytenoid (TA), lateral cricoarytenoid/interarytenoid (LCA/IA), cricothyroid (CT), all laryngeal adductors (LCA/IA/TA), and the posterior cricoarytenoid (PCA)...
October 16, 2018: Laryngoscope
Tommaso Rossi, Tomaso Caporossi, Stanislao Rizzo, Carlandrea Trillo, Serena Telani, Francesco Barca, Guido Ripandelli
PURPOSE: To review a series of highly myopic eyes with retinal detachment undergoing pars plana vitrectomy with autologous internal limiting membrane (ILM) flap placed over posterior retinal breaks located in areas of choroidal atrophy. METHODS: Retrospective review of 13 consecutive patients receiving pars plana vitrectomy with ILM flap over causative breaks, compared with 19 controls receiving the same surgery with ILM peeling but no ILM flap. Main outcome measures included anatomical success rate, visual acuity, number of surgeries and the rate of silicone oil removal...
October 15, 2018: British Journal of Ophthalmology
Pukhraj Rishi, Subramanian Krishnakumar, Jyotirmay Biswas, Sridevi Nair
Purpose: To report bilateral retinoblastoma in an 11-year-old child presenting with floaters and sub-internal limiting membrane (sub-ILM) seeds. Method: An 11-year-old child presented with floaters of 4 months' duration. Examination revealed circumscribed, whitish, subhyaloid, floccular nodules in the juxtapapillary region of both eyes. No solid tumor was seen. Swept-source optical coherence tomography revealed moderately reflective echoes in the sub-ILM space. Vitreous aspiration of sub-ILM deposits and cytopathological examination revealed retinoblastoma...
September 2018: Ocular Oncology and Pathology
Sunil Kumar Yadav, Ella Maria Kadas, Seyedamirhosein Motamedi, Konrad Polthier, Frank Haußer, Kay Gawlik, Friedemann Paul, Alexander Brandt
We present a method for optic nerve head (ONH) 3-D shape analysis from retinal optical coherence tomography (OCT). The possibility to noninvasively acquire in vivo high-resolution 3-D volumes of the ONH using spectral domain OCT drives the need to develop tools that quantify the shape of this structure and extract information for clinical applications. The presented method automatically generates a 3-D ONH model and then allows the computation of several 3-D parameters describing the ONH. The method starts with a high-resolution OCT volume scan as input...
October 2018: Journal of Biomedical Optics
Tajalli Ilm Chandel, Nida Zaidi, Masihuz Zaman, Ishrat Jahan, Aiman Masroor, Ibrar Ahmad Siddique, Shahid M Nayeem, Maroof Ali, Vladimir N Uversky, Rizwan Hasan Khan
Protein aggregation have been associated with several human neurodegenerative diseases, such as Parkinson's and Alzheimer's diseases. There are several small molecules that can reduce aggregation of proteins. The present study aimed to test the hypothesis that the application of more than one inhibitor either simultaneously or consecutively may result in more efficient inhibition of protein aggregation. To this end, the anti-amyloidogenic behaviour of benserazide hydrochloride (BH) and levodopa (LD) individually and in combination (BH + LD) was investigated using various biophysical, microscopic, and computational techniques...
October 9, 2018: Biochimica et biophysica acta. Proteins and proteomics
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