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https://www.readbyqxmd.com/read/30549048/ef%C3%AF-cacy-and-safety-of-sofosbuvir-based-therapy-in-hepatitis-c-virus-recurrence-post-living-donor-liver-transplant-a-real-life-egyptian-experience
#1
Ayman Yosry, Hadeel Gamal Eldeen, Eman Medhat, Mai Mehrez, Naglaa Zayed, Wafaa Elakel, Reham Abdelmoniem, Mona Kaddah, Ashraf Abdelaziz, Gamal Esmat, Magdy El-Serafy, Wahid Doss
BACKGROUND AND AIM: Direct acting antiviral has offered treatment of hepatitis C virus (HCV) recurrence post liver transplantation (LT) with an all-oral regimen for short duration, excellent safety profile, and high sustained virological response (SVR). The aim of this study was to evaluate the efficacy and safety of sofosbuvir (SOF)-based regimens in the real world among a cohort of Egyptian patients with recurrent HCV post living donor LT (LDLT). METHODS: Patients with HCV-G4 recurrence post-LDLT were recruited from National Committee of Control of Viral Hepatitis, Egypt, from November 2014 to May 2017...
December 14, 2018: Journal of Medical Virology
https://www.readbyqxmd.com/read/30546815/a-rare-case-of-laryngeal-cleft-in-association-with-vacterl-and-malrotation
#2
Chen Jesse, Stern Jonathan, Neuman Jeremy, Koshy June
We report a rare case of a neonatal girl who presented with coughing and dyspnea immediately after feeds. At birth, she was noted to have an imperforate anus with a posterior fourchette fistula from which she was stooling. Initial imaging with radiography showed a normal bowel gas pattern; however, lumbar vertebral anomalies were noted. An upper GI series was performed and revealed a laryngeal cleft and malrotation. Ultrasound confirmed malrotation with an abnormal SMA-SMV relationship. Since laryngeal cleft is a rare condition and may not be known to most radiologists, its incidence is likely underestimated...
March 2019: Radiology Case Reports
https://www.readbyqxmd.com/read/30539487/pancreaticoduodenectomy-with-mesocaval-shunt-for-locally-advanced-pancreatic-adenocarcinoma
#3
Eve Simoneau, Claire Goumard, Jeffrey E Lee, Jean-Nicolas Vauthey, Thomas A Aloia, Yun Shin Chun, Michael P Kim, Matthew H G Katz, Ching-Wei D Tzeng
INTRODUCTION: Patients with locally advanced pancreatic cancer (LAPC) represent a challenging group to treat, given the involvement of major vascular structures. In selected patients with favorable biology, temporary mesocaval shunt can facilitate the resection and allow for a safer procedure with enhanced exposure to the superior mesenteric vessels. METHODS: We present a video of a pancreaticoduodenectomy (PD) with temporary mesocaval shunt with left internal jugular (LIJ) vein conduit...
December 11, 2018: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/30535849/over-expression-of-gmkr3-a-tir-nbs-lrr-type-r-gene-confers-resistance-to-multiple-viruses-in-soybean
#4
Hongwei Xun, Xiangdong Yang, Hongli He, Meng Wang, Peng Guo, Ying Wang, Jinsong Pang, Yingshan Dong, Xianzhong Feng, Shucai Wang, Bao Liu
That overexpression of GmKR3 enhances innate virus resistance by stimulating. Soybean mosaic virus (SMV) is found in many soybean production areas, and SMV infection is one of the prevalent viral diseases that can cause significant yield losses in soybean. In plants, resistance (R) genes are involved in pathogen reorganization and innate immune response activation. Most R proteins have nucleotide-binding site and leucine-rich repeat (NBS-LRR) domains, and some of the NBS-LRR type R proteins in dicots have Toll/Interleukin-1 Receptor (TIR) motifs...
December 10, 2018: Plant Molecular Biology
https://www.readbyqxmd.com/read/30506433/increased-multiple-virus-resistance-in-transgenic-soybean-overexpressing-the-double-strand-rna-specific-ribonuclease-gene-pac1
#5
Xiangdong Yang, Lu Niu, Wei Zhang, Hongli He, Jing Yang, Guojie Xing, Dongquan Guo, Qianqian Zhao, Xiaofang Zhong, Haiyun Li, Qiyun Li, Yingshan Dong
Viruses constitute a major constraint to soybean production worldwide and are responsible for significant yield losses every year. Although varying degrees of resistance to specific viral strains has been identified in some soybean genetic sources, the high rate of mutation in viral genomes and mixed infections of different viruses or strains under field conditions usually hinder the effective control of viral diseases. In the present study, we generated transgenic soybean lines constitutively expressing the double-strand RNA specific ribonuclease gene PAC1 from Schizosaccharomyces pombe to evaluate their resistance responses to multiple soybean-infecting virus strains and isolates...
December 1, 2018: Transgenic Research
https://www.readbyqxmd.com/read/30502510/proteomic-profiling-reveals-key-cancer-progression-modulators-in-shed-microvesicles-released-from-isogenic-human-primary-and-metastatic-colorectal-cancer-cell-lines
#6
Wittaya Suwakulsiri, Alin Rai, Rong Xu, Maoshan Chen, David W Greening, Richard J Simpson
Extracellular vesicles can be classified into two main classes - exosomes and shed microvesicles (sMVs). Whilst much is known about exosome cargo and functionality, sMVs are poorly understood. Here, we describe the large-scale purification of sMVs released from primary (SW480) and metastatic (SW620) human isogenic colorectal cancer (CRC) cell lines using a combination of differential ultracentrifugation and isopycnic iodixanol density centrifugation. The yield of SW480-sMVs and SW620-sMVs was 0.75 mg and 0...
November 28, 2018: Biochimica et biophysica acta. Proteins and proteomics
https://www.readbyqxmd.com/read/30501987/can-post-hoc-video-review-of-robotic-pancreaticoduodenectomy-predict-portal-superior-mesenteric-vein-margin-status-in-pancreatic-adenocarcinoma
#7
Jae P Jung, Mazen S Zenati, Ahmad Hamad, Melissa E Hogg, Richard L Simmons, Amer H Zureikat, Herbert J Zeh, Brian A Boone
BACKGROUND: Achieving margin negative resection is a significant determinant of outcome in pancreatic adenocarcinoma (PDA). However, because of the fibrotic nature of PDA, it can be difficult to discriminate fibrosis from active disease intra-operatively. We sought to determine if post-hoc video review of robotic pancreatico-duodenectomy (RPD) could predict the portal/superior mesenteric vein (PV/SMV) margin status on final pathology. METHODS: Experienced pancreatic surgeons, blinded to patient and operative variables, reviewed the PV/SMV margin for available RPD videos of consecutive PDA patients from 9/2012 through 6/2017...
November 27, 2018: HPB: the Official Journal of the International Hepato Pancreato Biliary Association
https://www.readbyqxmd.com/read/30478805/acute-median-arcuate-ligament-syndrome-after-pancreaticoduodenectomy
#8
Daisuke Imai, Takashi Maeda, Huanlin Wang, Takahiro Ohmine, Keitaro Edahiro, Makoto Edagawa, Tomoyoshi Takenaka, Shohei Yamaguchi, Kozo Konishi, Shinichi Tsutsui, Hiroyuki Matsuda
BACKGROUND: Median arcuate ligament syndrome (MALS) can cause severe complications after pancreaticoduodenectomy (PD). Most of the reported cases of MALS have been diagnosed perioperatively and can be treated efficiently by interventional radiology or division of the median acute ligament (MAL) fibers. CASE REPORT: A 69-year-old woman underwent PD with resection of the SMV for pancreatic head cancer. Intraoperative exploration showed normal anatomy of the celiac trunk...
November 26, 2018: Surgical Case Reports
https://www.readbyqxmd.com/read/30469963/super-multi-view-near-eye-display-to-solve-vergence-accommodation-conflict
#9
Takaaki Ueno, Yasuhiro Takaki
A super multi-view (SMV) technique is applied to near-eye displays to solve the vergence-accommodation conflict that causes visual fatigue. The proposed SMV near-eye display employs a high-speed spatial light modulator (SLM), a two-dimensional (2D) light source array, and an imaging optics for each eye. The imaging optics produces a virtual image of the SLM and real images of the light sources to generate a 2D array of viewpoints. The SMV images are generated using a time-multiplexing technique: the multiple light sources sequentially emit light while the SLM synchronously displays corresponding parallax images...
November 12, 2018: Optics Express
https://www.readbyqxmd.com/read/30469132/simultaneous-quantification-of-simeprevir-sodium-a-hepatitis-c-protease-inhibitor-in-binary-and-ternary-mixtures-with-sofosbuvir-and-or-ledipasvir-utilizing-direct-and-h-point-standard-addition-strategies
#10
Sabrein H Mohamed, Yousry M Issa, Alyaa I Salim
Simeprevir sodium (SMV); a novel hepatitis C inhibitor, quells hepatitis C viral replication by binding to and repressing the protease, hepatitis C infection (HCV) NS3/4A. In this way, it is known as a prompt acting antiviral agent. Calibration curves of SMV were built in various solvents; ethanol, methanol, acetonitrile, chloroform and dichloromethane. It is obeyed up to 60.0 μg/mL; in all solvents at two maximum wavelengths (280 and 327 nm). Several investigations show that, SMV might be present in a mixture of Sofosbuvir (SOF) and/or Ledipasvir (LDP)...
July 6, 2018: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/30467724/multimodality-imaging-of-the-meso-rex-bypass
#11
REVIEW
Vincenzo Carollo, Gianluca Marrone, Kelvin Cortis, Giuseppe Mamone, Settimo Caruso, Mariapina Milazzo, Luigi Maruzzelli, Fabrizio di Francesco, Martin Delle, Roberto Miraglia, Jean de Ville de Goyet
Extrahepatic portal vein obstruction (EHPVO) is the most common cause of upper gastrointestinal bleeding in children. It is defined as thrombosis of the extrahepatic portal vein with or without extension to the intrahepatic portal veins. The Meso-Rex shunt is the gold standard treatment in children with favorable anatomy since it restores physiological portal liver reperfusion. This is achieved by rerouting the splanchnic venous blood through an autologous graft from the superior mesenteric vein (SMV) into the Rex recess of the left portal vein, curing portal hypertension by doing so...
November 22, 2018: Abdominal Radiology
https://www.readbyqxmd.com/read/30428441/intraoperative-catheter-directed-thrombolytic-therapy-for-the-treatment-of-superior-mesenteric-and-portal-vein-thrombosis
#12
M Marshad, M Maresch, T Al Abbasi
INTRODUCTION AND CASE PRESENTATION: Acute portal and superior mesenteric vein thrombosis(SMV) is a rare but potentially lethal condition that is often characterized by generalized and non-specific symptoms. A high index of suspicion is warranted for early diagnosis and management. We present a case of 54 year old male who presented with generalized abdominal pain which was later accompanied by hemodynamic instability and radiological diagnosis of portal vein and superior mesenteric vein thrombosis...
October 5, 2018: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/30370052/three-dimensional-surgical-simulation-of-the-bile-duct-and-vascular-arrangement-in-pancreatoduodenectomy-a-retrospective-cohort-study
#13
Ryoichi Miyamoto, Yukio Oshiro, Naoki Sano, Satoshi Inagawa, Nobuhiro Ohkohchi
Background/aims: We evaluated the usefulness of three-dimensional (3D) images for pancreatoduodenectomy (PD), including the classification of the bile duct and vascular arrangement, i.e., hepatic artery, inferior mesenteric vein (IMV) and left gastric vein (LGV). We evaluated the extent to which this simulation affected the perioperative outcomes of PD. Methods: In all, 117 patients who underwent PD were divided into the without-3D (n = 53) and with-3D (n = 64) groups, and perioperative outcomes were compared...
December 2018: Annals of Medicine and Surgery
https://www.readbyqxmd.com/read/30368199/superior-mesenteric-vein-injury-in-penetrating-abdominal-trauma-a-case-report
#14
Nada Faris Alhassan, Saad Mohammed Alsaawy, Ibrahim Tawfiq Albabtain
INTRODUCTION: Injury to the superior mesenteric vein (SMV) is considerably rare amongst abdominal visceral vascular injuries. Multiple factors play a role in identifying such injuries, leading to the high morbidity and mortality associated. CASE PRESENTATION: We report a twenty-six-year-old male sustaining a SMV injury following a self-inflected gun shot. Initial assessment of the patient reveals hemodynamic instability and intraabdominal hemorrhage. Surgically approaching the patient was performed in two stages...
2018: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/30355968/elements-involved-in-the-rsv3-mediated-extreme-resistance-against-an-avirulent-strain-of-soybean-mosaic-virus
#15
Mazen Alazem, Kuan-Chieh Tseng, Wen-Chi Chang, Jang-Kyun Seo, Kook-Hyung Kim
Extreme resistance (ER) is a type of R -gene-mediated resistance that rapidly induces a symptomless resistance phenotype, which is different from the phenotypical R -resistance manifested by the programmed cell death, accumulation of reactive oxygen species, and hypersensitive response. The Rsv3 gene in soybean cultivar L29 is responsible for ER against the avirulent strain G5H of soybean mosaic virus (SMV), but is ineffective against the virulent strain G7H. Rsv3-mediated ER is achieved through the rapid accumulation of callose, which arrests SMV-G5H at the point of infection...
October 24, 2018: Viruses
https://www.readbyqxmd.com/read/30334162/vascular-anatomy-of-the-transverse-mesocolon-and-bidirectional-laparoscopic-d3-lymph-node-dissection-for-patients-with-advanced-transverse-colon-cancer
#16
Takashi Ueki, Shuntato Nagai, Tatsuya Manabe, Ryo Koba, Kinuko Nagayoshi, Masafumi Nakamura, Masao Tanaka
Laparoscopic D3 lymph node dissection for transverse colon cancer is technically demanding because of complicated anatomy. Here, we reviewed the vascular structure of the transverse mesocolon, explored the extent of the base of the transverse mesocolon, and evaluated the feasibility and oncological safety of D3 lymph node dissection. We retrospectively reviewed the clinical records of 42 patients with advanced transverse colon cancer who underwent curative surgery and D3 dissection at Kyushu University Hospital between January 2008 and December 2015...
October 17, 2018: Surgical Endoscopy
https://www.readbyqxmd.com/read/30322713/renal-outcomes-following-left-renal-vein-harvest-for-venous-reconstruction-during-pancreas-and-liver-surgery
#17
Benjamin P T Loveday, Martin J Dib, Sangita Sequeira, Nouf Alotaiby, Robin Visser, Andrew S Barbas, Alice C Wei, Sean P Cleary, Carol-Anne Moulton, Steven Gallinger, Paul D Greig, Ian D McGilvray
BACKGROUND: The left renal vein (LRV) may be used for venous reconstruction during hepato-pancreato-biliary (HPB) surgery, although concerns exist about compromising renal function. This study aimed to determine renal outcomes following LRV harvest during HPB resections. METHODS: Circumferential PV/SMV resections from 2008 to 2014 were included within two groups (LRV harvest, Control). Absolute and change in Creatinine (Cr) and estimated GFR (eGFR), and rates of acute kidney injury (AKI) and chronic kidney disease (CKD), were compared...
October 12, 2018: HPB: the Official Journal of the International Hepato Pancreato Biliary Association
https://www.readbyqxmd.com/read/30302050/percutaneous-transhepatic-approach-for-recanalization-of-superior-mesenteric-and-portal-vein-in-a-patient-with-pancreatic-neuroendocrine-tumor-presenting-with-bleeding-duodenal-varices-a-brief-case-report
#18
Ajit Yadav, Gaurav Gangwani, Nitin Mishra, Arun Gupta
Occlusion of Portal Vein (PV) and Superior Mesenteric Vein (SMV) is a known effect of local infiltration by pancreatic or mesenteric neuroendocrine tumors. Venous occlusion leads to formation of collateral pathways to restore hepatopetal flow in main PV and these collateral pathways can be seen in the form of ectopic (duodenal or jejunal) varices. We present a case of bleeding duodenal varices secondary to SMV occlusion by a locally infiltrating pancreatic neuroendocrine tumor which was successfully treated by coil embolization of varices and SMV stenting of the occluded venous segment after failure of endoscopic glue injection...
September 2018: Journal of Clinical and Experimental Hepatology
https://www.readbyqxmd.com/read/30295500/analysis-of-adsorbed-layers-of-benzyldimethyldodecylammonium-bromide-on-silica-particles-in-water-using-the-sorbent-mass-variation-method
#19
Shasha Jiang, Na Du, Shue Song, Wanguo Hou
A "sorbent mass variation" (SMV) method has been suggested to investigate the adsorption at solid-liquid interfaces, which can provide information on the adsorbed layer structure including its thickness and composition. However, there has been little research focused on the method, and therefore, it is essential to examine its general applicability. Herein, the adsorption of benzyldimethyldodecylammonium bromide (BDDABr), a cationic surfactant, on silica (SiO2 ) nanoparticles (with ∼12 and 24 nm in size, denoted as S-SiO2 and L-SiO2 , respectively) in water was investigated using the SMV method...
October 30, 2018: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/30295086/hybrid-nanocarrier-system-for-guiding-and-augmenting-simvastatin-cytotoxic-activity-against-prostate-cancer
#20
Mohammed Sedki, Islam A Khalil, Ibrahim M El-Sherbiny
Prostate cancer is the most common non-skin cancer among men. Though statins are mainly used as antihyperlipidemic drugs, many studies have reported their proapoptotic and antimetastatic activities on prostate cancer. However, the poor solubility and insufficient delivery of statins in tumor site limit their anticancer activity. The present study introduces an efficient hybrid drug delivery system for the treatment of prostate cancer. The system involves the chemical conjugation of Simvastatin (SMV), a statin compound, to acid-terminated poly(D, L-lactic-co-glycolic acid), PLGA chains followed by its conversion into nanoparticles (NPs), with in situ physical incorporation of more SMV and superparamagnetic iron oxide nanoparticles (SPIONS) into the PLGA NPs...
October 8, 2018: Artificial Cells, Nanomedicine, and Biotechnology
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