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Takashi Ueki, Shuntato Nagai, Tatsuya Manabe, Ryo Koba, Kinuko Nagayoshi, Masafumi Nakamura, Masao Tanaka
Laparoscopic D3 lymph node dissection for transverse colon cancer is technically demanding because of complicated anatomy. Here, we reviewed the vascular structure of the transverse mesocolon, explored the extent of the base of the transverse mesocolon, and evaluated the feasibility and oncological safety of D3 lymph node dissection. We retrospectively reviewed the clinical records of 42 patients with advanced transverse colon cancer who underwent curative surgery and D3 dissection at Kyushu University Hospital between January 2008 and December 2015...
October 17, 2018: Surgical Endoscopy
Benjamin P T Loveday, Martin J Dib, Sangita Sequeira, Nouf Alotaiby, Robin Visser, Andrew S Barbas, Alice C Wei, Sean P Cleary, Carol-Anne Moulton, Steven Gallinger, Paul D Greig, Ian D McGilvray
BACKGROUND: The left renal vein (LRV) may be used for venous reconstruction during hepato-pancreato-biliary (HPB) surgery, although concerns exist about compromising renal function. This study aimed to determine renal outcomes following LRV harvest during HPB resections. METHODS: Circumferential PV/SMV resections from 2008 to 2014 were included within two groups (LRV harvest, Control). Absolute and change in Creatinine (Cr) and estimated GFR (eGFR), and rates of acute kidney injury (AKI) and chronic kidney disease (CKD), were compared...
October 12, 2018: HPB: the Official Journal of the International Hepato Pancreato Biliary Association
Ajit Yadav, Gaurav Gangwani, Nitin Mishra, Arun Gupta
Occlusion of Portal Vein (PV) and Superior Mesenteric Vein (SMV) is a known effect of local infiltration by pancreatic or mesenteric neuroendocrine tumors. Venous occlusion leads to formation of collateral pathways to restore hepatopetal flow in main PV and these collateral pathways can be seen in the form of ectopic (duodenal or jejunal) varices. We present a case of bleeding duodenal varices secondary to SMV occlusion by a locally infiltrating pancreatic neuroendocrine tumor which was successfully treated by coil embolization of varices and SMV stenting of the occluded venous segment after failure of endoscopic glue injection...
September 2018: Journal of Clinical and Experimental Hepatology
Shasha Jiang, Na Du, Shue Song, Wanguo Hou
A "sorbent mass variation" (SMV) method has been suggested to investigate the adsorption at solid-liquid interfaces, which can provide information on the adsorbed layer structure including its thickness and composition. However, there has been little research focused on the method, and therefore, it is essential to examine its general applicability. Herein, the adsorption of benzyldimethyldodecylammonium bromide (BDDABr), a cationic surfactant, on silica (SiO2 ) nanoparticles (with ∼12 and 24 nm in size, denoted as S-SiO2 and L-SiO2 , respectively) in water was investigated using the SMV method...
October 18, 2018: Langmuir: the ACS Journal of Surfaces and Colloids
Mohammed Sedki, Islam A Khalil, Ibrahim M El-Sherbiny
Prostate cancer is the most common non-skin cancer among men. Though statins are mainly used as antihyperlipidemic drugs, many studies have reported their proapoptotic and antimetastatic activities on prostate cancer. However, the poor solubility and insufficient delivery of statins in tumor site limit their anticancer activity. The present study introduces an efficient hybrid drug delivery system for the treatment of prostate cancer. The system involves the chemical conjugation of Simvastatin (SMV), a statin compound, to acid-terminated poly(D, L-lactic-co-glycolic acid), PLGA chains followed by its conversion into nanoparticles (NPs), with in situ physical incorporation of more SMV and superparamagnetic iron oxide nanoparticles (SPIONS) into the PLGA NPs...
October 8, 2018: Artificial Cells, Nanomedicine, and Biotechnology
Xingmao Zhang, Jie Zhang, Hua Fan, Yu Liu, Qiang He
This study was designed to explore the risk factors related to metastasis of para-aortic lymph node (PALN).Clinicopathologic data of 241 patients with resectable or borderline resectable pancreatic cancer who underwent pancreaticoduodenectomy with extended lymphadenectomy between January 2008 and December 2015 were collected, potential factors related to metastasis of PALN were analyzed.Positive rate of PALN was 19.5% (47/241). Univariate analysis showed that back pain (P = .028), preoperative CA19-9 level (P < ...
October 2018: Medicine (Baltimore)
Mureo Kasahara, Kengo Sasaki, Hajime Uchida, Yoshihiro Hirata, Masahiro Takeda, Akinari Fukuda, Seisuke Sakamoto
PV hypoplasia may increase the risk of posttransplant complications, especially when it extends to near the SMV and SpV junction. We described our experience of 10 pediatric cases of PV hypoplasia/thrombus in which the pullout technique was required for PV reconstruction. There were five male and five female patients. The median age was 9 months, and the median weight was 8.1 kg. The indications for the pullout technique were PV hypoplasia in seven patients and PV thrombus in 3. The inflow sites of the enlarged LGV were as follows: the main PV trunk (n = 2), the SMV and SpV junction (n = 4), and the SpV (n = 4)...
October 2, 2018: Pediatric Transplantation
Qingyong Chen, Xiaoming Shuai, Libo Chen
OBJECTIVE: To explore the safety and feasibility of the combined medial and caudal approach in laparoscopic D3 lymphadenectomy plus complete mesocolic excision(CME) for right hemicolectomy in the treatment of right hemicolon cancer complicated with incomplete ileus. METHODS: Clinical data of 65 patients with incomplete obstructive right-sided colon cancer (T1 to 4M0) diagnosed by abdominal CT enhanced scan or MRI and/or electric colonscope undergoing laparoscopic right hemicolectomy (D3 lymphadenectomy + CME) at Department of Emergency Medicine and Department of Gastrointestinal Surgery from June 2014 to June 2017 were retrospectively analyzed...
September 25, 2018: Zhonghua Wei Chang Wai Ke za Zhi, Chinese Journal of Gastrointestinal Surgery
Shintaro Akabane, Shoichiro Mukai, Hiroyuki Egi, Tomohiro Adachi, Masatoshi Kochi, Koki Sato, Yusuke Sumi, Ikki Nakashima, Kazuhiro Taguchi, Haruki Sada, Akira Ishikawa, Wataru Yasui, Hideki Ohdan
INTRODUCTION: The occurrence of colorectal cancer with tumor thrombosis in the mesenteric vein is very rare. Here, we report a case of ascending colon cancer with tumor thrombosis in the superior mesenteric vein (SMV) that was treated by complete resection. PRESENTATION OF CASE: A 48-year-old woman was initially admitted due to anemia. Ascending colon cancer coinciding with tumor thrombosis in the SMV was detected. Right hemicolectomy, tumor thrombectomy, and greater saphenous vein grafting of the SMV were performed...
September 9, 2018: International Journal of Surgery Case Reports
Guanwei Wu, Xiaoyan Cui, Hui Chen, Justin B Renaud, Kangfu Yu, Xin Chen, Aiming Wang
Endocytosis and endosomal trafficking regulate the proteins targeted to the plasma membrane and play essential roles in diverse cellular processes including responses to pathogen attack. Here, we report the identification of an endocytosis dynamin-like protein 5A (GmSDL5A) associated with purified soybean mosaic virus (SMV) virions from soybean using a top-down proteomics approach. Knock-down of GmSDL5A and its homologous gene GmSDL12A inhibits SMV infection in soybean. The role of analogous dynamin-like proteins in potyvirus infection was further confirmed and investigated using the Arabidopsis/turnip mosaic virus (TuMV) pathosystem...
September 26, 2018: Journal of Virology
Ifukibot L Usende, James O Olopade, Benjamin O Emikpe, Ademola A Oyagbemi, Adeolu A Adedapo
Vanadium is a contaminant of crude oil that released into the atmosphere through burning of fossil fuels. The mechanism by which it exerts toxic influences had not been fully elucidated in African giant rat (AGR). This study investigates the mechanisms of sodium metavanadate (SMV) induced oxidative stress in AGR. A total of 24 adult male AGR weighing 600-850 g were used. Animals were randomly divided into six groups. Groups 1, 3 and 5 served as control while groups 2, 4 and 6 were treated with intraperitoneal 3 mg/kg body weight of SMV for 3, 7 and 14 days, respectively...
June 2018: International Journal of Veterinary Science and Medicine
Ammar A Javed, Michael J Wright, Ayat Siddique, Alex B Blair, Ding Ding, Richard A Burkhart, Martin Makary, John L Cameron, Amol Narang, Joseph Herman, Lei Zheng, Daniel Laheru, Matthew J Weiss, Christopher Wolfgang, Jin He
INTRODUCTION: Approximately, 20% of patients with pancreatic ductal adenocarcinoma have resectable disease at diagnosis. Given improvements in locoregional and systemic therapies, some patients with borderline resectable pancreatic cancer (BRPC) can now undergo successful resection. The outcomes of patients with BRPC after neoadjuvant therapy remain unclear. METHODS: A prospectively maintained single-institution database was utilized to identify patients with BRPC who were managed at the Johns Hopkins Pancreas Multidisciplinary Clinic (PMDC) between 2013 and 2016...
September 21, 2018: Journal of Gastrointestinal Surgery: Official Journal of the Society for Surgery of the Alimentary Tract
Huali Wu, Wenting Lv, Qi Pan, Praveen Kumar Kalavagunta, Qiongzhen Liu, Guohong Qin, Minxuan Cai, Liangliang Zhou, Tao Wang, Zhenjiang Xia, Jing Shang
BACKGROUND: A high-fat diet (HFD)-induced obesity/hyperlipidemia is accompanied by hormonal and neurochemical changes that can be associated with depression. Emerging studies indicate that simvastatin (SMV, decreasing cholesterol levels) has therapeutic effects on neurological and neuropsychiatric diseases through hippocampal-dependent function. However, the studies on the HFD exposure in adolescent animals, which investigate the neuroprotective effects of SMV on the hippocampal morphology, serotonin (5-HT) system and inflammation, are limited...
January 15, 2019: Journal of Affective Disorders
David Martin, David Petermann, Sara Fontanella, Yan Pu, Nermin Halkic, Nicolas Demartines, Markus Schäfer
OBJECTIVES: Technical feasibility and safety of portal vein (PV) and superior mesenteric vein (SMV) resection during pancreaticoduodenectomy (PD) for cancer has been confirmed, but oncological benefits remain unclear. The present study aimed to explore the long-term outcomes of PD with PV/SMV resection and proven histologically invasion. PATIENTS AND METHODS: A total of 95 consecutive PD were performed between January 2008 and August 2013, and 29 patients underwent PV/SMV resection with histologically proven venous tumor infiltration...
September 14, 2018: European Journal of Gastroenterology & Hepatology
Atsushi Hiroishi, Takayuki Yamada, Tsuyoshi Morimoto, Kuniyasu Horikoshi, Yasuo Nakajima
PURPOSE: To prospectively correlate the preoperative vessel anatomy in three-dimensional computed tomographic angiography with computed tomographic colonography (3D-CTA with CTC) with that in laparoscopic surgery for colorectal cancer. METHODS: The study protocol was approved by our institutional review board. The study population consisted of 101 patients with colon cancer who underwent 3D-CTA with CTC between June 2016 and January 2018. Two radiologists assessed the branching patterns of sigmoid arteries (SAs) and right colonic artery (RCA), the position between the ileocolic artery (ICA) and superior mesenteric vein (SMV), and the existence of an accessory middle colonic artery (aMCA)...
September 14, 2018: Japanese Journal of Radiology
Xiangbing Deng, Tao Hu, Mingtian Wei, Qingbin Wu, Tinghan Yang, Wenjian Meng, Ziqiang Wang
BACKGROUND: Complete mesocolic excision (CME) with central ligation or D3 lymphadenectomy has been reported to provide increased lymph node retrieval with the prospect of superior oncological results in colon cancer. However, right hemicolectomy with CME or D3 lymphadenectomy by laparoscopy is considered to be a technically challenging and time-consuming procedure with a higher risk of causing intraoperative injuries. Here, we introduce a novel laparoscopic approach for the D3 right hemicolectomy and report its feasibility, safety, and efficacy in cancer clearance...
September 2018: Langenbeck's Archives of Surgery
Ryosuke Okura, Shigetsugu Takano, Tetsuo Yokota, Hideyuki Yoshitomi, Shingo Kagawa, Katsunori Furukawa, Tsukasa Takayashiki, Satoshi Kuboki, Daisuke Suzuki, Nozomu Sakai, Hiroyuki Nojima, Takashi Mishima, Masaru Miyazaki, Masayuki Ohtsuka
The standard treatment for locally advanced unresectable (UR-LA) pancreatic ductal adenocarcinoma (PDAC) is chemo-radiotherapy. Surgery following chemo-radiotherapy (conversion surgery), has been considered a useful strategy and has been used for UR-LA PDAC. The current study presents the case of a 43-year-old woman who complained of back pain. A radiological examination revealed a pancreatic tumor in contact with >270 degrees of the superior mesenteric artery (SMA) perimeter, with invasion extending from the superior mesenteric vein (SMV) to the portal vein (PV)...
October 2018: Molecular and Clinical Oncology
Suguru Ito, Masaaki Higashiyama, Kazuki Horiuchi, Akinori Mizoguchi, Shigeyoshi Soga, Rina Tanemoto, Shin Nishii, Hisato Terada, Akinori Wada, Nao Sugihara, Yoshinori Hanawa, Hirotaka Furuhashi, Takeshi Takajo, Kazuhiko Shirakabe, Chikako Watanabe, Shunsuke Komoto, Kengo Tomita, Shigeaki Nagao, Masami Shinozaki, Akihiko Nakagawa, Michio Kubota, Daisuke Miyagishima, Nobuaki Gotoh, Soichiro Miura, Hideki Ueno, Ryota Hokari
We herein report a 44-year-old man suffering from systemic edema due to protein-losing enteropathy (PLE) with superior mesenteric vein (SMV) obstruction and development of collateral veins, which subsequently proved to be a chronic result of thrombosis and a complication of Crohn's disease (CD). PLE was supposedly induced by both intestinal erosion and thrombosis-related lymphangiectasia, which was histologically proven in his surgically-resected ileal stenosis. Elemental diet and anti-TNFα agent improved his hypoalbuminemia after surgery...
September 12, 2018: Internal Medicine
Neha Goel, Jimson W D'Souza, Karen J Ruth, Barton Milestone, Andreas Karachristos, Rajeswari Nagarathinam, Harry Cooper, John Hoffman, Sanjay Reddy
Controversy exists on accurately grading vascular involvement on preoperative imaging for pancreatic ductal adenocarcinoma. We reviewed the association between preoperative imaging and margin status in 137 patients. Radiologists graded venous involvement based on the Ishikawa classification system and arterial involvement based on preoperative imaging. For patients with both classifications recorded, we categorized vascular involvement as "None," "Arterial only," "Venous only," or "Both" and examined the association of vascular involvement and pathologic margin status...
2018: Journal of Oncology
Darragh F Halpenny, Marcus Goncalves, Emily Schwitzer, Jennifer Golia Pernicka, Jasmyne Jackson, Stephanie Gandelman, Chaya S Moskowitz, Michael Postow, Marina Mourtzakis, Bette Caan, Lee W Jones, Andrew J Plodkowski
OBJECTIVE: Evaluate the accuracy of CT-derived regional skeletal muscle volume (SMV) measurements to predict whole body SMV in patients with melanoma. METHODS: 148 patients with advanced melanoma who underwent whole body positron emission tomography/CT were studied. Whole body SMV was measured on CT and used as the reference standard. CT-derived regional measures of SMV were obtained in the thorax, abdomen, pelvis, and lower limbs. Models were developed on a discovery cohort (n-98), using linear regression to model whole body SMV as a function of each regional measure, and clinical factors...
October 3, 2018: British Journal of Radiology
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