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Immunomodulator

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https://www.readbyqxmd.com/read/29666625/dying-to-be-noticed-epigenetic-regulation-of-immunogenic-cell-death-for-cancer-immunotherapy
#1
REVIEW
Brianne Cruickshank, Michael Giacomantonio, Paola Marcato, Sherri McFarland, Jonathan Pol, Shashi Gujar
Immunogenic cell death (ICD) activates both innate and adaptive arms of the immune system during apoptotic cancer cell death. With respect to cancer immunotherapy, the process of ICD elicits enhanced adjuvanticity and antigenicity from dying cancer cells and consequently, promotes the development of clinically desired antitumor immunity. Cancer ICD requires the presentation of various "hallmarks" of immunomodulation, which include the cell-surface translocation of calreticulin, production of type I interferons, and release of high-mobility group box-1 and ATP, which through their compatible actions induce an immune response against cancer cells...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29666112/increased-erythrophagocytosis-induces-ferroptosis-in-red-pulp-macrophages-in-a-mouse-model-of-transfusion
#2
Lyla A Youssef, Abdelhadi Rebbaa, Sergey Pampou, Stuart P Weisberg, Brent R Stockwell, Eldad A Hod, Steven L Spitalnik
Macrophages play important roles in recycling iron derived from the clearance of red blood cells (RBCs). They are also a critically important component of host defense, protecting against invading pathogens. However, the effects on macrophage biology of acutely ingesting large numbers of RBCs are not completely understood. To investigate this issue, we used a mouse model of RBC transfusion and clearance, which mimics the clinical setting. In this model, transfusions of refrigerator storage-damaged (i.e., "old") RBCs led to increased erythrophagocytosis by splenic red pulp macrophages (RPMs)...
April 17, 2018: Blood
https://www.readbyqxmd.com/read/29665255/concise-review-rational-use-of-mesenchymal-stem-cells-in-the-treatment-of-ischemic-heart-disease
#3
REVIEW
Michael R Ward, Armin Abadeh, Kim A Connelly
The capacity of stem and progenitor cells to stimulate cardiac regeneration has been studied for almost 20 years, with very promising preclinical data and mixed clinical results. Several cell types have been studied, identified by their cell surface markers, differentiation capacity and their secreted growth factors. Bone marrow derived mesenchymal stem cells (MSCs) have been found to have potent regenerative capacity, through multiple mechanisms, including mesoderm lineage differentiation, immunomodulation, and paracrine stimulation...
April 17, 2018: Stem Cells Translational Medicine
https://www.readbyqxmd.com/read/29664038/-cedrus-deodara-in-vitro-antileishmanial-efficacy-immumomodulatory-activity
#4
Shyam Narayan, Chandreshwar Prasad Thakur, Shiv Bahadur, Meenakshi Thakur, Shashi Nath Pandey, Ajit Kumar Thakur, Dipendra K Mitra, Pulok K Mukherjee
Background & objectives: The existing antileishmanial drugs for complete cure of visceral leishmaniasis (kala-azar) are limited. The available drugs are either toxic or less effective leading to disease relapse or conversion to post-kala-azar dermal leishmaniasis. Several herbal extracts have been shown to have antileishmanial activity, but a herbal drug may not always be safe. In the present study, the extract of Cedrus deodara leaves has been standardized and tested for immunomodulatory antileishmanial activities...
December 2017: Indian Journal of Medical Research
https://www.readbyqxmd.com/read/29662751/blood-transfusion-and-postoperative-infection-in-spine-surgery-a-systematic-review
#5
Christian Fisahn, Cameron Schmidt, Josh E Schroeder, Emiliano Vialle, Isador H Lieberman, Joseph R Dettori, Thomas A Schildhauer
Study Design: Systematic review. Objectives: Allogeneic blood transfusion-related immunomodulation may relatively suppress the immune system, heightening the risk of infection following spine surgery. This systematic review seeks to determine whether allogeneic blood transfusion increases the risk of postoperative infection and whether there are any factors that modify this association. Methods: PubMed, Cochrane Central Register of Controlled Trials, and reference lists from included studies were searched from inception to April 20, 2017 to identify studies examining the risk of infection following allogeneic blood transfusion in adult patients receiving surgery for degenerative spine disease...
April 2018: Global Spine Journal
https://www.readbyqxmd.com/read/29662450/poly-ethylene-glycol-polylactide-micelles-for-cancer-therapy
#6
REVIEW
Jixue Wang, Shengxian Li, Yuping Han, Jingjing Guan, Shirley Chung, Chunxi Wang, Di Li
For the treatment of malignancy, many therapeutic agents, including small molecules, photosensitizers, immunomodulators, proteins and genes, and so forth, have been loaded into nanocarriers for controllable cancer therapy. Among these nanocarriers, polymeric micelles have been considered as one of the most promising nanocarriers, some of which have already been applied in different stages of clinical trials. The successful advantages of polymeric micelles from bench to bedside are due to their special core/shell structures, which can carry specific drugs in certain disease conditions...
2018: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29661929/arginase-1-expression-in-myeloid-cells-regulates-s-aureus-planktonic-but-not-biofilm-infection
#7
Kelsey J Yamada, Cortney E Heim, Amy L Aldrich, Casey M Gries, Anna G Staudacher, Tammy Kielian
S. aureus is a leading cause of device-associated biofilm infections, which represent a serious health care concern based on their chronicity and antibiotic resistance. We previously reported that S. aureus biofilms preferentially recruit myeloid-derived suppressor cells (MDSCs), which promote monocyte and macrophage anti-inflammatory properties. This is associated with increased myeloid arginase-1 (Arg-1) expression, which has been linked to anti-inflammatory and pro-fibrotic activity that are observed during S...
April 16, 2018: Infection and Immunity
https://www.readbyqxmd.com/read/29661282/impact-of-fresh-frozen-plasma-transfusion-on-postoperative-inflammation-and-prognosis-of-colorectal-liver-metastases
#8
Yuichi Nakaseko, Koichiro Haruki, Hiroaki Shiba, Takashi Horiuchi, Nobuhiro Saito, Taro Sakamoto, Takeshi Gocho, Katsuhiko Yanaga
BACKGROUND: Blood transfusion has been reported to be associated with immunomodulation and poor oncologic outcomes in several malignancies. The aim of the study is to investigate the influence of the use of fresh frozen plasma (FFP) on long-term outcomes in patients with colorectal liver metastases (CRLM) after hepatic resection. MATERIALS AND METHODS: The study comprised 127 patients who had undergone first hepatic resection for CRLM between April 2000 and December 2013...
June 2018: Journal of Surgical Research
https://www.readbyqxmd.com/read/29660466/formononetin-an-isoflavone-from-astragalus-membranaceus-inhibits-proliferation-and-metastasis-of-ovarian-cancer-cells
#9
Jing Zhang, Likun Liu, Jing Wang, Baoyin Ren, Lin Zhang, Weiling Li
ETHNOPHARMACOLOGICAL RELEVANCE: Astragalus membranaceus which was originally described in the Shennong's Classic of Materia Medica, the earliest complete Pharmacopoeia of China written from the Warring States Period to Han Dynasty, has been widely used in Chinese medicine for>2,000 years, especially in the prescription of curing cancer. A. membranaceus has various bioactivities, such as anti-tumor, anti-viral, anti-oxidant, anti-diabetes, anti-inflammation, anti-atherosclerosis, immunomodulation, hepatoprotection, hematopoiesis, neuroprotection and so on...
April 13, 2018: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29657376/smoke-inhalation-injury-etiopathogenesis-diagnosis-and-management
#10
REVIEW
Kapil Gupta, Mayank Mehrotra, Parul Kumar, Anoop Raj Gogia, Arun Prasad, Joseph Arnold Fisher
Smoke inhalation injury is a major determinant of morbidity and mortality in fire victims. It is a complex multifaceted injury affecting initially the airway; however, in short time, it can become a complex life-threatening systemic disease affecting every organ in the body. In this review, we provide a summary of the underlying pathophysiology of organ dysfunction and provide an up-to-date survey of the various critical care modalities that have been found beneficial in caring for these patients. Major pathophysiological change is development of edema in the respiratory tract...
March 2018: Indian Journal of Critical Care Medicine
https://www.readbyqxmd.com/read/29655744/immunomodulatory-acidic-polysaccharides-from-zizyphus-jujuba-cv-huizao-insights-into-their-chemical-characteristics-and-modes-of-action
#11
Man Zou, Yilun Chen, Dongxiao Sun-Waterhouse, Yuhuan Zhang, Feng Li
Chinese jujube is commonly used in folklore medicine. This study aimed to examine the in vivo immunomodulatory activity of two acidic polysaccharides, HP1 and HP2, extracted and purified from Zizyphus jujuba cv. Huizao (which remains extensively unexplored). HP1 and HP2 had the same monosaccharide species and manganese contents, but differed in their molar rhamnose, arabinose, mannose, glucose, galactose and uronic acid contents (7.32 and 35.9%, as galacturonic acid), Mw (68.7 and 111 kDa, respectively), and contents of K, Cr, Cu, Zn, Pb and Ca...
August 30, 2018: Food Chemistry
https://www.readbyqxmd.com/read/29653378/possible-origins-of-consciousness-in-simple-control-over-involuntary-neuroimmunological-action
#12
REVIEW
Kevin B Clark
The origin(s) and purpose(s) of consciousness continue to be fervently debated by neuroscientists. A recent unconventional hypothesis put forth by Morsella et al. suggests the primary function of consciousness is the integration, selection, and execution of advantageous lower-level voluntary skeletal muscle behavior on surrounding external environments. However, at main issue is whether more precise, adaptable voluntary skeletal motor action, and therefore the corresponding workings of consciousness, first emerged and evolved in animals to exert control over external environments or internal ones regulated by less flexible autonomic function...
April 10, 2018: Consciousness and Cognition
https://www.readbyqxmd.com/read/29652798/the-double-face-of-exosome-carried-micrornas-in-cancer-immunomodulation
#13
REVIEW
Romina Alfonsi, Ludovica Grassi, Michele Signore, Désirée Bonci
In recent years many articles have underlined the key role of nanovesicles, i.e., exosomes, as information carriers among biological systems including cancer. Tumor-derived exosomes (TEXs) are key players in the dynamic crosstalk between cancer cells and the microenvironment while promote immune system control evasion. In fact, tumors are undoubtedly capable of silencing the immune response through multiple mechanisms, including the release of exosomes. TEXs have been shown to boost tumor growth and promote progression and metastatic spreading via suppression or stimulation of the immune response towards cancer cells...
April 13, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29651939/role-of-sertoli-cell-proteins-in-immunomodulation
#14
Giovanni Luca, Tiziano Baroni, Iva Arato, Barbara Hansen, Don Cameron, Riccardo Calafiore
Several publications have been written reviewing the basic physiology of the mammalian Sertoli cell, but the aim of this review is to summarize some of the recent findings regarding the immunomodulatory role of Sertoli cells, and especially the key Sertoli cell regulatory proteins that are associated with the well-defined immune privileged status of the testis. A better definition and understanding of these Sertoli cell proteins and the mechanisms of immuno-protection should help to elucidate their role in damage of the spermatogenic process and their role in cell therapy for a number of cell-mediated chronic diseases...
April 12, 2018: Protein and Peptide Letters
https://www.readbyqxmd.com/read/29650268/efficacy-and-toxicity-profile-of-carfilzomib-based-regimens-for-treatment-of-multiple-myeloma-a-systematic-review
#15
REVIEW
Adeela Mushtaq, Vikas Kapoor, Azka Latif, Ahmad Iftikhar, Umar Zahid, Ali McBride, Ivo Abraham, Irbaz Bin Riaz, Faiz Anwer
Standard induction therapy for multiple myeloma is three-drug combination based on following classes of drugs: proteasome inhibitors, immunomodulators and steroids. Despite its notable efficacy, bortezomib has side effects like peripheral neuropathy (PNP) with reported incidence of grade ≥3 PNP between 2%-23% Schlafer et al., 2017. Carfilzomib (CFZ) has high selectivity and minimal off-target adverse effects including lower rates of PNP. CFZ is already approved for treatment of relapsed and refractory multiple myeloma (RRMM) as single agent as well as in combination with lenalidomide and/or dexamethasone...
May 2018: Critical Reviews in Oncology/hematology
https://www.readbyqxmd.com/read/29645394/cicatricial-alopecia
#16
Varvara Kanti, Joachim Röwert-Huber, Annika Vogt, Ulrike Blume-Peytavi
In the classification of the North American Hair Research Society, primary cicatricial alopecias (PCA) are divided into four groups according to their prominent inflammatory infiltrate: PCAs with lymphocytic, neutrophilic, mixed or nonspecific cell inflammation pattern. The hair loss can begin subclinically and progress slowly so that the exact onset of the disease is often difficult to determine. The diagnosis is often delayed. While most forms of cicatricial alopecia can be clearly diagnosed based on clinical presentation in the acute disease stage, diagnosis can be challenging in the subacute, early or late disease stages...
April 2018: Journal der Deutschen Dermatologischen Gesellschaft, Journal of the German Society of Dermatology: JDDG
https://www.readbyqxmd.com/read/29643001/immune-cell-bdnf-expression-in-treatment-na%C3%A3-ve-relapsing-remitting-multiple-sclerosis-patients-and-following-one-year-of-immunomodulation-therapy
#17
Alicja Kalinowska-Łyszczarz, Mikołaj A Pawlak, Aleksandra Wyciszkiewicz, Krystyna Osztynowicz, Wojciech Kozubski, Sławomir Michalak
Although neurons are the main source of neurotrophins in the healthy brain, neurotrophins can also be expressed in the immune system. We have previously shown that in relapsing-remitting multiple sclerosis (RRMS) lower immune-cell neurotrophin levels are associated with brain atrophy and cognitive impairment. The aim of the present study was to assess if immune-cell neurotrophin expression is impaired in MS as compared with the healthy controls, and to describe if these levels change in treatment-naïve RRMS patients, following one year of immunomodulation...
March 29, 2018: Neurologia i Neurochirurgia Polska
https://www.readbyqxmd.com/read/29642953/impact-of-bone-marrow-mesenchymal-stem-cell-immunomodulation-on-the-osteogenic-effects-of-laponite
#18
Tao Li, Zhong Long Liu, Ming Xiao, Ze Zheng Yang, Ming Zheng Peng, Cui Di Li, Xiao Jun Zhou, Jin Wu Wang
BACKGROUND: With the development of osteoimmunology and bone tissue engineering (BTE), it has been recognized that the immunomodulatory properties of bone biomaterials have considerable impact in determining their fate after implantation. In this regard, the polarization of macrophages secondary to biomaterials is postulated to play a crucial role in modulating their osteogenesis; thus, strategies that may facilitate this process engender increasing levels of attention. Whereas a variety of reports highlight the immunomodulation of bone marrow mesenchymal stem cells (BMSCs) in cell therapy or their osteogenesis in BTE, few have focused on the effect of BMSCs in promoting osteogenesis in BTE through regulating the phenotype of macrophages...
April 11, 2018: Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/29642394/neuroprotective-effects-of-platonin-a-therapeutic-immunomodulating-medicine-on-traumatic-brain-injury-in-mice-after-controlled-cortical-impact
#19
Ting-Lin Yen, Chao-Chien Chang, Chi-Li Chung, Wen-Chin Ko, Chih-Hao Yang, Cheng-Ying Hsieh
Traumatic brain injury (TBI) is one of the leading causes of mortality worldwide and leads to persistent cognitive, sensory, motor dysfunction, and emotional disorders. TBI-caused primary injury results in structural damage to brain tissues. Following the primary injury, secondary injuries which are accompanied by neuroinflammation, microglial activation, and additional cell death subsequently occur. Platonin, a cyanine photosensitizing dye, has been used to treat trauma, ulcers, and some types of acute inflammation...
April 6, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29629338/metabolic-symbiosis-and-immunomodulation-how-tumor-cell-derived-lactate-may-disturb-innate-and-adaptive-immune-responses
#20
REVIEW
Alexandre Morrot, Leonardo Marques da Fonseca, Eduardo J Salustiano, Luciana Boffoni Gentile, Luciana Conde, Alessandra Almeida Filardy, Tatiany Nunes Franklim, Kelli Monteiro da Costa, Celio Geraldo Freire-de-Lima, Leonardo Freire-de-Lima
The tumor microenvironment (TME) is composed by cellular and non-cellular components. Examples include the following: (i) bone marrow-derived inflammatory cells, (ii) fibroblasts, (iii) blood vessels, (iv) immune cells, and (v) extracellular matrix components. In most cases, this combination of components may result in an inhospitable environment, in which a significant retrenchment in nutrients and oxygen considerably disturbs cell metabolism. Cancer cells are characterized by an enhanced uptake and utilization of glucose, a phenomenon described by Otto Warburg over 90 years ago...
2018: Frontiers in Oncology
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