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https://www.readbyqxmd.com/read/28822188/-characterization-and-activity-effect-on-adh-of-polysaccharides-from-mori-fructus
#1
Xing Wang, Qing-Fang Deng, Hua-Guo Chen, Xin Zhou
Mori Fructus polysaccharides (MFPs) have been used as a source of therapeutic agents. The most promising activities of these biopolymers are their immunomodulation and anti-cancer effects. It was reported that polysaccharides were a potential drug against liver injury, but the hepatoprotective effect of MFPs was ambiguous. In this study, the fractionation of crude polysaccharides on DEAE-Cellulose 52 gave four fractions (MFP-1, MFP-2, MFP-2 and MFP-4). The results showed that the contents of carbohydrates were 75...
June 2017: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/28822000/effects-of-fusariotoxin-co-exposure-on-thp-1-human-immune-cells
#2
Marie-Caroline Smith, Stéphanie Madec, Samuel Troadec, Emmanuel Coton, Nolwenn Hymery
Deoxynivalenol (DON), nivalenol (NIV), T-2 toxin (T2), fumonisin B1 (FB1), zearalenone (ZEA), and moniliformin (MON) mycotoxins are common food and feed contaminants produced by Fusarium spp. However, while they are usually found to co-occur in a large range of commodities, only few data are available on mycotoxin co-exposure effects and cellular response mechanisms. In this study, the individual and combined toxic effects of these fusariotoxins were evaluated on the THP-1 human immune cell line as major fusariotoxins are mostly potent immunomodulators...
August 18, 2017: Cell Biology and Toxicology
https://www.readbyqxmd.com/read/28821152/the-common-lavender-lavandula-angustifolia-mill-pectic-polysaccharides-modulate-phagocytic-leukocytes-and-intestinal-peyer-s-patch-cells
#3
Yordan N Georgiev, Berit S Paulsen, Hiroaki Kiyohara, Milan Ciz, Manol H Ognyanov, Ondrej Vasicek, Frode Rise, Petko N Denev, Haruki Yamada, Antonin Lojek, Vesselin Kussovski, Hilde Barsett, Albert I Krastanov, Irina Z Yanakieva, Maria G Kratchanova
Two pectic (chPS-L1, chPS-L2) and one polyphenolic (chPP-L) fractions were obtained from lavender flowers after boiling water extraction, exhaustive removing of alcohol-soluble molecules and SEC. chPS-L1 (52.4kDa) contains mainly low-acetylated and high-methoxylated homogalacturonans (HG), and smaller rhamnogalacturonan (RG) I backbone fragments rich in 1,3,5-branched arabinan and arabinogalactan (AG) II side chains. chPS-L2 (21.8kDa) contains predominantly similarly esterified HG, followed by RGI with AGII structures and RGII...
October 15, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28821115/rheology-and-bioactivity-of-high-molecular-weight-dextrans-synthesised-by-lactic-acid-bacteria
#4
Kenza Zarour, Mª Goretti Llamas, Alicia Prieto, Patricia Rúas-Madiedo, María Teresa Dueñas, Pilar Fernández de Palencia, Rosa Aznar, Mebrouk Kihal, Paloma López
Dextrans synthesised by three Leuconostoc mesenteroides strains, isolated from mammalian milks, were studied and compared with dextrans produced by Lc. mesenteroides and Lactobacillus sakei strains isolated from meat products. Size exclusion chromatography coupled with multiangle laser light scattering detection analysis demonstrated that the dextrans have molecular masses between 1.74×10(8)Da and 4.41×10(8)Da. Rheological analysis of aqueous solutions of the polymer revealed that all had a pseudoplastic behaviour under shear conditions and a random, and flexible, coil structure...
October 15, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28819194/hdac3-inhibition-ameliorates-spinal-cord-injury-by-immunomodulation
#5
Tomoharu Kuboyama, Shalaka Wahane, Yong Huang, Xiang Zhou, Jamie K Wong, Andrew Koemeter-Cox, Michael Martini, Roland H Friedel, Hongyan Zou
Following spinal cord injury (SCI), the innate immune response of microglia and infiltrating macrophages clears up cellular debris and promotes tissue repair, but it also inflicts secondary injury from inflammatory responses. Immunomodulation aimed at maximizing the beneficial effects while minimizing the detrimental roles of the innate immunity may aid functional recovery after SCI. However, intracellular drivers of global reprogramming of the inflammatory gene networks in the innate immune cells are poorly understood...
August 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28819018/adjuvant-treatment-of-anogenital-warts-with-systemic-interferon-a-systematic-review-and-meta-analysis
#6
Lukas Westfechtel, Ricardo Niklas Werner, Corinna Dressler, Matthew Gaskins, Alexander Nast
BACKGROUND: Interferons are natural messenger proteins that are used to treat various disease entities. Due to their immunomodulating, antiviral and antiproliferative effects, the systemic administration of interferons after ablative treatment for anogenital warts (AGWs) has been advocated to increase clearance and decrease recurrence rates. However, studies investigating the efficacy of adjuvant systemic interferon have yielded inconsistent results. The objective of this systematic review and meta-analysis was to comprehensively assess and evaluate the available evidence from randomised controlled trials...
August 17, 2017: Sexually Transmitted Infections
https://www.readbyqxmd.com/read/28818657/activity-guided-isolation-and-structural-identification-of-immunomodulating-substances-from-pleurotus-eryngii-byproducts
#7
Yanan Sun, Wenxiang Li
A two-step extraction process was used to investigate the bioactive substances from the byproducts of the fungus Pleurotus eryngii. Methanol extraction followed by extraction using different polar solvents coupled with silica column chromatography was carried out to separate the bioactive components. The immunomodulating activity of the extracts was investigated using Ana-1 mouse macrophage cells. At 25μg/mL, the butyl alcohol extract showed the highest enhancement of Ana-1 cell proliferative activity and secretion of cytokines...
August 14, 2017: International Immunopharmacology
https://www.readbyqxmd.com/read/28818625/the-therapeutic-potential-of-crth2-dp2-beyond-allergy-and-asthma
#8
REVIEW
Katharina Jandl, Akos Heinemann
Prostaglandin (PG) D2 has been in the focus of research for quite a long time, but its biological effects and its roles in human disease are still not fully characterized. When in 2001 a second major PGD2 receptor termed chemoattractant receptor homologue expressed on Th2 cells (CRTH2; alternative name DP2) was discovered, diverse investigations started to shed more light on the complex and often controversial actions of the prostaglandin. With various immunomodulating effects, such as induction of migration, activation, and cytokine release of leukocytes observed both in vivo and in vitro, CRTH2 has emerged as a promising target for the treatment of allergic diseases...
August 14, 2017: Prostaglandins & Other Lipid Mediators
https://www.readbyqxmd.com/read/28818362/two-year-follow-up-of-crohn-s-patients-substituted-to-certolizumab-anti-tnfa-therapy-savant-2
#9
Andrew Motlis, Moheb Boktor, Paul Jordan, Urska Cvek, Marjan Trutschl, J Steven Alexander
The effectiveness of ant-TNF 'biologic' therapy in is well supported in the management of moderate to severe Crohn's Disease (CD). Our first 'SAVANT' study was to our knowledge the first study report one- year outcomes in patients (n=60) who switched from previous anti-TNFa treatment to Cimzia/Certolizumab. This current study (SAVANT 2) follows up on longer term outcomes and provides additional clinical and biochemical data that may contribute to therapeutic responses. This IRB approved study was a retrospective analysis of the initial patients included in SAVANT 1...
August 9, 2017: Pathophysiology: the Official Journal of the International Society for Pathophysiology
https://www.readbyqxmd.com/read/28818044/effects-of-the-vertically-transmitted-microsporidian-facilispora-margolisi-and-the-parasiticide-emamectin-benzoate-on-salmon-lice-lepeophtheirus-salmonis
#10
Jordan D Poley, Ben J G Sutherland, Mark D Fast, Ben F Koop, Simon R M Jones
BACKGROUND: Microsporidia are highly specialized, parasitic fungi that infect a wide range of eukaryotic hosts from all major taxa. Infections cause a variety of damaging effects on host physiology from increased stress to death. The microsporidian Facilispora margolisi infects the Pacific salmon louse (Lepeophtheirus salmonis oncorhynchi), an economically and ecologically important ectoparasitic copepod that can impact wild and cultured salmonids. RESULTS: Vertical transmission of F...
August 17, 2017: BMC Genomics
https://www.readbyqxmd.com/read/28815811/study-of-the-effects-of-spray-drying-in-whey-starch-on-the-probiotic-capacity-of-lactobacillus-rhamnosus-64-in-the-gut-of-mice
#11
L Lavari, P Burns, R Páez, J Reinheimer, G Vinderola
AIMS: To evaluate the effects of spray-drying of Lactobacillus rhamnosus 64 on its capacity to modulate the gut immune response and on the attenuation of TNBS-induced colitis in mice. METHODS AND RESULTS: L. rhamnosus 64 was spray-dried in cheese whey-starch solution and administered to mice for three, six or ten consecutive days. Peritoneal macrophage phagocytic activity, secretory-IgA (S-IgA) levels in the small intestinal fluid and TNFα, IFNγ, IL-10, IL-6 and IL-2 levels in homogenates of the small and large intestine were determined...
August 17, 2017: Journal of Applied Microbiology
https://www.readbyqxmd.com/read/28812358/bioinspired-active-stealth-magneto-nanomicelles-for-theranostics-combining-efficient-mri-and-enhanced-drug-delivery
#12
Kai-Long Zhang, Jie Zhou, Hong Zhou, Ying Wu, Rui Liu, Li-Li Wang, Wei-Wen Lin, Guoming Huang, Huang-Hao Yang
The mononuclear phagocyte system (MPS), with key roles in recognition and clearance of foreign particles, is a major constraint to nanoparticle-based delivery systems. The desire to improve the delivery efficiency has prompted the search for stealthy long-circulating nanoplatforms. Herein, we design an antiphagocytic delivery system with "active" stealth behavior for cancer theranostics combining efficient MRI and enhanced drug delivery. We modify self-peptide, a synthetic peptide for active immunomodulation, to biodegradable poly (lactide-glycolide)-poly (ethylene glycol) (PLGA-PEG), then utilize the self-assembly properties of PLGA-PEG to form nanomicelles that encapsulating iron oxide (IO) nanoparticles and anticancer drug paclitaxel (PTX)...
August 16, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28812098/-radiological-response-assessment-of-modern-immunotherapy-using-irecist
#13
REVIEW
T Persigehl, T D Poeppel, O Sedlaczek
CLINICAL/METHODICAL ISSUE: Modern immunotherapies in oncology show tumor response patterns differing from conventional chemotherapies including initial pseudo-progression. STANDARD RADIOLOGICAL METHODS: Response evaluation criteria in solid tumors (RECIST 1.1) represent the currently most used response criteria for conventional chemotherapy of solid tumors. However, atypical response patterns of immunotherapies are not correctly classified using RECIST 1.1 so that the effectiveness is also incorrectly interpreted...
August 15, 2017: Der Radiologe
https://www.readbyqxmd.com/read/28811841/bacteriophages-in-the-gastrointestinal-tract-and-their-implications
#14
Marzanna Łusiak-Szelachowska, Beata Weber-Dąbrowska, Ewa Jończyk-Matysiak, Renata Wojciechowska, Andrzej Górski
The gut microbiota plays an essential role in health and disease of humans. Bacteriophages are the most abundant members of the gut virobiota and display great diversity. Phages can translocate through the mucosa to lymph and internal organs and play a role as regulators of the bacterial population in the gut. Increasing abundance of phages in the gut mucosa may reduce colonization by bacteria. Moreover, phages may have an immunomodulatory role in the immune response in the human gut. The role of phages in inflammatory bowel disease (IBD) remains unknown...
2017: Gut Pathogens
https://www.readbyqxmd.com/read/28809991/treatment-of-inverse-intertriginous-psoriasis-updated-guidelines-from-the-medical-board-of-the-national-psoriasis-foundation
#15
Hasan Khosravi, Michael P Siegel, Abby S Van Voorhees, Joseph F Merola
<p>Inverse or intertriginous psoriasis commonly involves skin fold areas including the axillae, perianal skin, intergluteal cleft, inframammary, genital/inguinal, abdominal, and retroauricular folds. After reviewing the literature for new treatments, a task force was convened to update a consensus on inverse psoriasis therapy. Short-term treatment continues to be low-potency topical steroids. In order to avoid steroid-induced adverse effects, long-term therapy includes topical immunomodulators, calcitriol, and calcipotriene...
August 1, 2017: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/28808390/immunomodulatory-cytotoxicity-and-antioxidant-activities-of-roots-of-ziziphus-mauritiana
#16
Samina Afzal, Murium Batool, Bashir Ahmad Ch, Ashfaq Ahmad, Muhammad Uzair, Khurram Afzal
AIMS: The study is conducted to evaluate the immunomodulatory, cytotoxicity, and antioxidant potential of Ziziphus mauritiana (Rhamnaceae). Phytochemical analysis of Z. mauritiana revealed the presence of alkaloids, anthraquinone glycoside, cardiac glycoside, saponin, tannin, and flavonoids. METHODOLOGY: The cytotoxicity of the plant Z. mauritiana was evaluated by brine shrimp lethality test. Antioxidant parameters such as superoxide dismutase (SOD), total antioxidant capacity (T-AOC), and malondialdehyde (MDA) levels were calculated in the plasma of rats after chronic administration of 400 mg/kg of Z...
July 2017: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/28807724/the-versatile-functions-of-lrr-only-proteins-in-mollusk-chlamys-farreri
#17
Mengqiang Wang, Lingling Wang, Zhihao Jia, Xiudan Wang, Qilin Yi, Zhao Lv, Linsheng Song
Leucine-rich repeat (LRR)-only proteins are involved in the innate immune responses as they mediate protein-ligand interactions. In the present study, three novel LRR-only proteins, CfLRRop-4, CfLRRop-5 and CfLRRop-6, were identified and characterized from Zhikong scallop Chlamys farreri. They all contained LRR motifs with consensus signature sequences of LxxLxLxxNxL or LxxLxLxxCxxL. All the mRNA transcripts of three CfLRRops were high abundant in hepatopancreas, gills and gonads, and their mRNA transcripts in hemocytes could respond to the stimulations of different microbes, including Vibrio anguillarum, Micrococcus luteus and Pichia pastoris...
August 11, 2017: Developmental and Comparative Immunology
https://www.readbyqxmd.com/read/28806274/transfusion-related-immunomodulation-a-reappraisal
#18
Lyla A Youssef, Steven L Spitalnik
PURPOSE OF REVIEW: This review summarizes current and prior observations regarding transfusion-related immunomodulation (TRIM) and puts these ideas into a modern immunological context, incorporating concepts from innate, adaptive, and nutritional immunity. We propose that TRIM research focus on determining whether there are specific, well-defined immunosuppressive effects from transfusing 'pure' red blood cells (RBCs) themselves, along with the by-products produced by the stored RBCs as a result of the 'storage lesion...
August 12, 2017: Current Opinion in Hematology
https://www.readbyqxmd.com/read/28804863/personalised-immunomodulating-treatments-for-graves-disease-fact-or-fiction
#19
Tristan Mirko Struja, Alexander Kutz, Stefan Fischli, Christian Meier, Beat Müller, Philipp Schütz
Although Graves' disease has been recognised for more than 100 years, its physiopathological mechanisms are incompletely understood. Treatment strategies today mainly focus on suppression of thyroid hormone production by use of antithyroid drugs or radio-iodine, but neglect the underlying immunological mechanisms. Although Graves' disease is often seen as a prototype for an autoimmune mechanism, it is more likely to be a heterogeneous syndrome showing characteristics of both autoimmunity and immunodeficiency...
August 14, 2017: Swiss Medical Weekly
https://www.readbyqxmd.com/read/28803057/cross-reactivity-and-cross-immunomodulation-between-venoms-of-the-snakes-bothrops-asper-crotalus-simus-and-lachesis-stenophrys-and-its-effect-in-the-production-of-polyspecific-antivenom-for-central-america
#20
Cynthia Arroyo, Sergio Solano, Álvaro Segura, María Herrera, Ricardo Estrada, Mauren Villalta, Mariángela Vargas, José María Gutiérrez, Guillermo León
A mixture of the venoms of Bothrops asper, Crotalus simus and Lachesis stenophrys is used as immunogen to produce the polyspecific Central American antivenom (PoliVal-ICP). In this work, we studied the ability of each of these venoms to modulate the antibody response induced by the other two venoms included in the immunization mixture. For that, equine monospecific, bispecific and polyspecific antivenoms were prepared and compared regarding their ability to neutralize the phospholipase A2, coagulant and lethal activities of each venom, and their anti-venom antibodies concentration...
August 9, 2017: Toxicon: Official Journal of the International Society on Toxinology
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