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Psoas lumbar vertebra index

Elizabeth M Cespedes Feliciano, Egor Avrutin, Bette J Caan, Adam Boroian, Marina Mourtzakis
BACKGROUND: Low skeletal muscle quantified using computed tomography (CT) scans is associated with morbidity and mortality among cancer patients. However, existing methods to assess skeletal muscle from CT are time-consuming, expensive, and require training. Clinic-friendly tools to screen for low skeletal muscle in cancer patients are urgently needed. METHODS: We included 807 scans from non-metastatic colorectal cancer patients. With the digital ruler available in most radiological software, we implemented an abbreviated method to assess skeletal muscle area at the third lumbar vertebra (L3), which consisted of assessing the height and width of the psoas and paraspinal muscles and computing their combined 'linear area' in centimetres squared (cm2 )...
July 31, 2018: Journal of Cachexia, Sarcopenia and Muscle
Maria Kalafateli, Andreas Karatzas, Georgios Tsiaoussis, Efstratios Koutroumpakis, Paraskevi Tselekouni, Nikolaos Koukias, Christos Konstantakis, Stelios Assimakopoulos, Charalambos Gogos, Konstantinos Thomopoulos, Christina Kalogeropoulou, Christos Triantos
Background: Ongoing evidence suggests that sarcopenia adversely affects outcomes in cirrhosis. The aim of this study was to evaluate muscle fat infiltration as a component of sarcopenia and its prognostic value in this setting. Methods: In 98 consecutive patients with cirrhosis, muscle density was measured during a computed tomography scan at the level of the fourth to fifth lumbar (L4) vertebrae. Univariate and multivariate Cox regression analysis was used to determine predictors of survival...
July 2018: Annals of Gastroenterology: Quarterly Publication of the Hellenic Society of Gastroenterology
Ryota Nakamura, Yoshihisa Inage, Rika Tobita, Satoshi Yoneyama, Takeshi Numata, Kyoko Ota, Hidetoshi Yanai, Takeo Endo, Yukinori Inadome, Shingo Sakashita, Hiroaki Satoh, Kenji Yuzawa, Toru Terashima
INTRODUCTION: Skeletal muscle depletion, referred to as sarcopenia, has recently been identified as a risk factor for poor outcomes in various malignancies. However, the prognostic significance of sarcopenia in patients with NSCLC after surgery has not been adequately determined. This study investigated the impact of sarcopenia in patients undergoing pulmonary resection for lung cancer. METHODS: This retrospective study consisted of 328 patients with pathologically confirmed NSCLC who underwent curative resection between January 2005 and April 2017...
July 2018: Journal of Thoracic Oncology
Egor Avrutin, Lesley L Moisey, Roselyn Zhang, Jenna Khattab, Emma Todd, Tahira Premji, Rosemary Kozar, Daren K Heyland, Marina Mourtzakis
BACKGROUND: Computed tomography (CT) scans performed during routine hospital care offer the opportunity to quantify skeletal muscle and predict mortality and morbidity in intensive care unit (ICU) patients. Existing methods of muscle cross-sectional area (CSA) quantification require specialized software, training, and time commitment that may not be feasible in a clinical setting. In this article, we explore a new screening method to identify patients with low muscle mass. METHODS: We analyzed 145 scans of elderly ICU patients (≥65 years old) using a combination of measures obtained with a digital ruler, commonly found on hospital radiological software...
July 2018: JPEN. Journal of Parenteral and Enteral Nutrition
Masashi Yamashita, Kentaro Kamiya, Atsuhiko Matsunaga, Tadashi Kitamura, Nobuaki Hamazaki, Ryota Matsuzawa, Kohei Nozaki, Shinya Tanaka, Takeshi Nakamura, Emi Maekawa, Takashi Masuda, Junya Ako, Kagami Miyaji
BACKGROUND: Low skeletal muscle density, determined using computed tomography (CT), has yet to be examined in terms of muscle function and prognostic capability in patients who require open cardiovascular surgery. This study was performed to examine whether psoas muscle area and density, determined using CT, are associated with postoperative mortality in patients who undergo cardiovascular surgery. METHODS: We reviewed the findings in 773 consecutive patients who underwent preoperative CT imaging, including the level of the third lumbar vertebra for clinical purposes...
December 2017: Canadian Journal of Cardiology
Hideyuki Abe, Kohei Takei, Toshitaka Uematsu, Yuumi Tokura, Issei Suzuki, Kazumasa Sakamoto, Daisaku Nishihara, Yoshiyuki Yamaguchi, Tomoya Mizuno, Akinori Nukui, Minoru Kobayashi, Takao Kamai
BACKGROUND: Recently, numerous studies have reported an association between sarcopenia and poor outcomes in various kinds of malignancies. We investigated whether sarcopenia predicts the survival of patients with metastatic urothelial carcinoma who underwent systemic chemotherapy. METHODS: We reviewed 87 metastatic urothelial carcinoma patients who underwent chemotherapy (gemcitabine plus cisplatin or gemcitabine plus carboplatin for cisplatin-unfit patients) between 2007 and 2015...
April 2018: International Journal of Clinical Oncology
Ji Sun Kim, Won Young Kim, Hyun Kyung Park, Myung Chun Kim, Woong Jung, Byuk Sung Ko
OBJECTIVE: Until now, cutoff values of low skeletal muscle mass using computed tomography (CT) were driven by optimal stratification to predict mortality in cancer patients. The aim of the present study was to investigate the simple, age-specific, cutoff value of low skeletal muscle mass by CT in healthy adults. DESIGN: This is a retrospective, observational, single-center study. SETTING: This study was performed in the health screening department of a university-affiliated hospital during a 10-year period...
2017: Annals of Nutrition & Metabolism
Tomoyuki Yoshikawa, Masashi Takano, Morikazu Miyamoto, Isao Yajima, Yukihiro Shimizu, Yusuke Aizawa, Yuki Suguchi, Miki Moriiwa, Tadashi Aoyama, Hiroaki Soyama, Tomoko Goto, Junko Hirata, Ayako Suzuki, Hidenori Sasa, Isao Nagaoka, Hitoshi Tsuda, Kenichi Furuya
PURPOSE: Low skeletal muscle mass (sarcopenia) has been reported to have an influence on survival and toxicities of chemotherapy in several solid tumors. The impact of sarcopenia on the treatment of ovarian cancers has not been determined. The present study aimed to evaluate correlation between sarcopenia and toxicities of chemotherapy in ovarian cancers. METHODS: Medical charts of the ovarian cancer patients that received chemotherapy with paclitaxel and carboplatin at our hospital between 2010 and 2015 were retrospectively reviewed...
September 2017: Cancer Chemotherapy and Pharmacology
Yves Ntilikina, David Bahlau, Julien Garnon, Sébastien Schuller, Axel Walter, Mickaël Schaeffer, Jean-Paul Steib, Yann Philippe Charles
OBJECTIVE Percutaneous instrumentation in thoracolumbar fractures is intended to decrease paravertebral muscle damage by avoiding dissection. The aim of this study was to compare muscles at instrumented levels in patients who were treated by open or percutaneous surgery. METHODS Twenty-seven patients underwent open instrumentation, and 65 were treated percutaneously. A standardized MRI protocol using axial T1-weighted sequences was performed at a minimum 1-year follow-up after implant removal. Two independent observers measured cross-sectional areas (CSAs, in cm2 ) and region of interest (ROI) signal intensity (in pixels) of paravertebral muscles by using OsiriX at the fracture level, and at cranial and caudal instrumented pedicle levels...
August 2017: Journal of Neurosurgery. Spine
Ferdinand Seith, Holger Schmidt, Julia Kunz, Thomas Küstner, Sergios Gatidis, Konstantin Nikolaou, Christian la Fougère, Nina Schwenzer
The aim of our study was to evaluate the effect of stepwise-reduced doses on objective and subjective image parameters and on oncologic readings in whole-body (18)F-FDG PET/MRI. Methods: We retrospectively simulated the stepwise reduction of (18)F-FDG doses of 19 patients (mean age ± SD, 50.9 ± 11.7 y; mean body mass index ± SD, 22.8 ± 3.2 kg/m(2)) who received a whole-body PET/MRI examination from 3 to 0.5 MBq/kg of body weight (kgBW) in intervals of 0.25. Objective imaging parameters were assessed by measuring the SUV and coefficient of variation in different regions (aorta, liver, spleen, kidney, small bowel, lumbar vertebra, psoas muscle, urinary bladder) as well as the noise-equivalent counting rates in each bed position...
October 2017: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
I J G Rutten, J Ubachs, R F P M Kruitwagen, D P J van Dijk, R G H Beets-Tan, L F A G Massuger, S W M Olde Damink, T Van Gorp
BACKGROUND: Sarcopenia, severe skeletal muscle loss, has been identified as a prognostic factor in various malignancies. This study aims to investigate whether sarcopenia is associated with overall survival (OS) and surgical complications in patients with advanced ovarian cancer undergoing primary debulking surgery (PDS). METHODS: Ovarian cancer patients (n = 216) treated with PDS were enrolled retrospectively. Total skeletal muscle surface area was measured on axial computed tomography at the level of the third lumbar vertebra...
April 2017: European Journal of Surgical Oncology
Nicolas Golse, Petru Octav Bucur, Oriana Ciacio, Gabriella Pittau, Antonio Sa Cunha, René Adam, Denis Castaing, Teresa Antonini, Audrey Coilly, Didier Samuel, Daniel Cherqui, Eric Vibert
Although sarcopenia is a common complication of cirrhosis, its diagnosis remains nonconsensual: computed tomography (CT) scan determinations vary and no cutoff values have been established in cirrhotic populations undergoing liver transplantation (LT). Our aim was to compare the accuracy of the most widely used measurement techniques and to establish useful cutoffs in the setting of LT. From the 440 patients transplanted between January 2008 and May 2011 in our tertiary center, we selected 256 patients with cirrhosis for whom a recent CT scan was available during the 4 months prior to LT...
February 2017: Liver Transplantation
Daniel Delitto, Sarah M Judge, Thomas J George, George A Sarosi, Ryan M Thomas, Kevin E Behrns, Steven J Hughes, Andrew R Judge, Jose G Trevino
BACKGROUND: The relationship between myopenia, nutritional status, and long-term oncologic outcomes remains poorly characterized in patients with clinically resectable pancreatic cancer. We sought to reliably quantify prognostic indicators of preoperative cachexia in a manner applicable to any clinical setting. METHODS: Preoperative computed tomographies were available electronically and suitable for analysis in 73 of 82 consecutive patients with pancreatic cancer undergoing pancreatoduodenectomy between November 2010 and February 2014...
April 2017: Surgery
Atsushi Hiraoka, Masashi Hirooka, Yohei Koizumi, Hirofumi Izumoto, Hidetaro Ueki, Miho Kaneto, Shogo Kitahata, Toshihiko Aibiki, Hideomi Tomida, Yuji Miyamoto, Hiroka Yamago, Yoshifumi Suga, Ryuichiro Iwasaki, Kenichiro Mori, Hideki Miyata, Eiji Tsubouchi, Masato Kishida, Tomoyuki Ninomiya, Masanori Abe, Bunzo Matsuura, Hideki Kawasaki, Yoichi Hiasa, Kojiro Michitaka
AIM: To elucidate the clinical significance of muscle wasting in regard to survival of hepatocellular carcinoma (HCC) patients undergoing sorafenib treatment, we evaluated prognostic factors including muscle wasting at the start of sorafenib treatment. METHODS: We enrolled 93 patients with unresectable HCC (68.3 ± 9.4 years old, 81 men, 12 women, Child-Pugh score 5:6:7 = 69:22:2) who were treated with sorafenib. Muscle wasting was evaluated based on psoas muscle area index (psoas muscle area at level of middle of third lumbar vertebra [cm(2) ] / height [m](2) ) calculated from computed tomography findings...
May 2017: Hepatology Research: the Official Journal of the Japan Society of Hepatology
Yuhei Hamaguchi, Toshimi Kaido, Shinya Okumura, Atsushi Kobayashi, Ahmed Hammad, Yumiko Tamai, Nobuya Inagaki, Shinji Uemoto
OBJECTIVES: Low skeletal muscle, referred to as sarcopenia, has been shown to be an independent predictor of lower overall survival in various kinds of diseases. Several studies have evaluated the low skeletal muscle mass using computed tomography (CT) imaging. However, the cutoff values based on CT imaging remain undetermined in Asian populations. METHODS: Preoperative plain CT imaging at the third lumbar vertebrae level was used to measure the psoas muscle mass index (PMI, cm(2)/m(2)) in 541 adult donors for living donor liver transplantation (LDLT)...
November 2016: Nutrition
L Ebbeling, D J Grabo, M Shashaty, R Dua, S S Sonnad, C A Sims, J L Pascual, C W Schwab, D N Holena
INTRODUCTION: Central sarcopenia as a surrogate for frailty has recently been studied as a predictor of outcome in elderly medical patients, but less is known about how this metric relates to outcomes after trauma. We hypothesized that psoas:lumbar vertebral index (PLVI), a measure of central sarcopenia, is associated with increased morbidity and mortality in elderly trauma patients. METHODS: A query of our institutional trauma registry from 2005 to 2010 was performed...
February 2014: European Journal of Trauma and Emergency Surgery: Official Publication of the European Trauma Society
Owoicho Adogwa, S Harrison Farber, Parastou Fatemi, Rupen Desai, Aladine Elsamadicy, Joseph Cheng, Carlos Bagley, Oren Gottfried, Robert E Isaacs
Obese patients undergoing lumbar spinal fusion surgery are a challenge to the operating surgeon. Direct lateral interbody fusion (DLIF) has been performed for degenerative disease of the lumbar spine with good outcomes; nevertheless, how obese patients fare compared to non-obese patients after DLIF remains unknown. The primary aim of this study is to compare rates of postoperative complications and long-term outcomes between obese and non-obese patients undergoing DLIF. Sixty-three patients (obese: 29, non-obese: 34) undergoing index DLIF for degenerative disease of the spine between 2010 and 2012 at our institution were retrospectively enrolled...
March 2016: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
Hesham Mostafa Zakaria, Lonni Schultz, Feras Mossa-Basha, Brent Griffith, Victor Chang
OBJECT Improved objective assessments of perioperative risk after spine surgery are necessary to decrease postoperative morbidity and mortality rates. Morphometric analysis has proven utility in predicting postoperative morbidity and mortality in surgical disciplines. The aim of the present study was to evaluate whether morphometrics can be applied to the cases of patients undergoing lumbar spine surgery. METHODS The authors performed a retrospective review of the perioperative course of 395 patients who underwent lumbar surgery at their institution from 2013 to 2014...
October 2015: Neurosurgical Focus
Satoru Taguchi, Nobuhiko Akamatsu, Tohru Nakagawa, Wataru Gonoi, Atsushi Kanatani, Hideyo Miyazaki, Tetsuya Fujimura, Hiroshi Fukuhara, Haruki Kume, Yukio Homma
BACKGROUND: The purpose of the study was to evaluate the prognostic value of sarcopenia (muscle loss) in patients with metastatic urothelial carcinoma (UC), in a comparison of several methods of computed tomography (CT)-based evaluation of sarcopenia. PATIENTS AND METHODS: We retrospectively reviewed 100 patients with metastatic UC who underwent first-line systemic chemotherapy between 2003 and 2014. Sarcopenia was assessed by the following CT-based methods: skeletal muscle index (SMI), total psoas area (TPA), axial and/or transversal psoas thickness at the level of the third lumbar vertebrae, and axial and/or transversal psoas thickness at the umbilicus level (U-TPT)...
June 2016: Clinical Genitourinary Cancer
Mitsuru Yagi, Naobumi Hosogane, Kota Watanabe, Takashi Asazuma, Morio Matsumoto
BACKGROUND CONTEXT: Various factors are reported to affect the spinal alignment in degenerative lumbar scoliosis (DLS). Although trunk muscles also appear to affect spinal alignment, the role of the trunk muscles is not yet clear. PURPOSE: The aim was to elucidate the role of the multifidus (MF) and psoas (PS) in maintaining global spinal alignment in patients with DLS. STUDY DESIGN: This was a multicenter retrospective matched cohort study...
April 2016: Spine Journal: Official Journal of the North American Spine Society
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