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Total psoas area index

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https://www.readbyqxmd.com/read/30066490/screening-for-low-muscularity-in-colorectal-cancer-patients-a-valid-clinic-friendly-approach-that-predicts-mortality
#1
Elizabeth M Cespedes Feliciano, Egor Avrutin, Bette J Caan, Adam Boroian, Marina Mourtzakis
BACKGROUND: Low skeletal muscle quantified using computed tomography (CT) scans is associated with morbidity and mortality among cancer patients. However, existing methods to assess skeletal muscle from CT are time-consuming, expensive, and require training. Clinic-friendly tools to screen for low skeletal muscle in cancer patients are urgently needed. METHODS: We included 807 scans from non-metastatic colorectal cancer patients. With the digital ruler available in most radiological software, we implemented an abbreviated method to assess skeletal muscle area at the third lumbar vertebra (L3), which consisted of assessing the height and width of the psoas and paraspinal muscles and computing their combined 'linear area' in centimetres squared (cm2 )...
July 31, 2018: Journal of Cachexia, Sarcopenia and Muscle
https://www.readbyqxmd.com/read/30040184/relationship-between-total-body-protein-and-cross-sectional-skeletal-muscle-area-in-liver-cirrhosis-is-influenced-by-overhydration
#2
Cameron I Wells, John L McCall, Lindsay D Plank
Sarcopenia as defined by reduced skeletal muscle area (SMA) on cross-sectional abdominal imaging has been proposed as an objective measure of malnutrition, and is associated with both waitlist mortality and post-transplant complications in patients with cirrhosis. SMA, however, has never been validated against the gold-standard measurement of total body protein (TBP) by in vivo neutron activation analysis (IVNAA). Furthermore, overhydration is common in cirrhosis and its effect on muscle area measurement remains unknown...
July 24, 2018: Liver Transplantation
https://www.readbyqxmd.com/read/30005446/the-ratio-between-estimated-glomerular-filtration-rates-egfr-of-creatinine-and-cystatin-c-predicts-overall-survival-in-patients-with-hepatocellular-carcinoma
#3
Yasuyuki Tamai, Motoh Iwasa, Yuya Kawasaki, Naohiko Yoshizawa, Suguru Ogura, Ryosuke Sugimoto, Akiko Eguchi, Norihiko Yamamoto, Kazushi Sugimoto, Hiroshi Hasegawa, Yoshiyuki Takei
AIM: Hepatocellular carcinoma (HCC) patients with sarcopenia have a poor survival, but there are no predictive markers for survival relating to muscle mass and liver function. Therefore, we investigated whether the ratio between estimated glomerular filtration rates of serum creatinine (Scre) and serum cystain C (Scys) (eGFRcre/eGFRcys) can be used as a predictive marker of survival in HCC patients. METHODS: First, the correlation between Scre/Scys ratio and muscle mass was examined in 50 patients with chronic liver disease...
July 13, 2018: Hepatology Research: the Official Journal of the Japan Society of Hepatology
https://www.readbyqxmd.com/read/29991895/muscle-fat-infiltration-assessed-by-total-psoas-density-on-computed-tomography-predicts-mortality-in-cirrhosis
#4
Maria Kalafateli, Andreas Karatzas, Georgios Tsiaoussis, Efstratios Koutroumpakis, Paraskevi Tselekouni, Nikolaos Koukias, Christos Konstantakis, Stelios Assimakopoulos, Charalambos Gogos, Konstantinos Thomopoulos, Christina Kalogeropoulou, Christos Triantos
Background: Ongoing evidence suggests that sarcopenia adversely affects outcomes in cirrhosis. The aim of this study was to evaluate muscle fat infiltration as a component of sarcopenia and its prognostic value in this setting. Methods: In 98 consecutive patients with cirrhosis, muscle density was measured during a computed tomography scan at the level of the fourth to fifth lumbar (L4) vertebrae. Univariate and multivariate Cox regression analysis was used to determine predictors of survival...
July 2018: Annals of Gastroenterology: Quarterly Publication of the Hellenic Society of Gastroenterology
https://www.readbyqxmd.com/read/29944880/preoperative-sarcopenia-portends-worse-outcomes-after-descending-thoracic-aortic-aneurysm-repair
#5
Akiko Tanaka, Harleen K Sandhu, Zainulabdeen Al Rstum, RanaO Afifi, Charles C Miller, Kristofer M Charlton-Ouw, Maria E Codreanu, Naveed U Saqib, Hazim J Safi, Anthony L Estrera
BACKGROUND: Sarcopenia may be an indicator of frailty. We used total psoas area index (TPAI) to identify sarcopenia and evaluated the effect of preoperative TPAI on outcomes following descending thoracic aortic aneurysm (DTAA) repair. METHODS: DTAA patients between 2007-2015 undergoing thoracic endovascular aortic repair (TEVAR) and open surgical repair (OSR) with available preoperative imaging were analyzed. Sarcopenia was defined as TPAI<6.5cm2 /m2 . Adverse event was defined as composite endpoint comprised of three or more multi-system complications, discharge to other than home or death within 30 days...
June 23, 2018: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/29898443/patient-s-skeletal-muscle-radiation-attenuation-and-sarcopenic-obesity-are-associated-with-postoperative-morbidity-after-neoadjuvant-chemoradiation-and-resection-for-rectal-cancer
#6
Annefleur E M Berkel, Joost M Klaase, Feike de Graaff, Marjolein G J Brusse-Keizer, Bart C Bongers, Nico L U van Meeteren
BACKGROUND/AIMS: To investigate the relation between skeletal muscle measurements (muscle mass, radiation attenuation, and sarcopenic obesity), postoperative morbidity, and survival after treatment of locally advanced rectal cancer. METHODS: This explorative retrospective study identified 99 consecutive patients who underwent neoadjuvant chemoradiation and surgery between January 2007 and May 2012. Skeletal muscle mass was measured as total psoas area and total abdominal muscle area (TAMA) at 3 anatomical levels using the patient's preoperative computed tomography scan...
June 13, 2018: Digestive Surgery
https://www.readbyqxmd.com/read/29564168/impact-of-sarcopenia-in-borderline-resectable-and-locally-advanced-pancreatic-cancer-patients-receiving-stereotactic-body-radiation-therapy
#7
William H Jin, Eric A Mellon, Jessica M Frakes, Gilbert Z Murimwa, Pamela J Hodul, Jose M Pimiento, Mokenge P Malafa, Sarah E Hoffe
Background: Total psoas area (TPA), a marker of sarcopenia, has been used as an independent predictor of clinical outcomes in gastrointestinal (GI) cancers as a proxy for frailty and nutritional status. Our study aimed to evaluate whether TPA, in contrast to traditional measurements of nutrition like body mass index (BMI) and body surface area (BSA), was predictive of outcomes in borderline resectable pancreatic cancer (BRPC) and locally advanced pancreatic cancer (LAPC) patients receiving stereotactic body radiation therapy (SBRT)...
February 2018: Journal of Gastrointestinal Oncology
https://www.readbyqxmd.com/read/29534880/the-impact-of-changes-in-radiographic-sarcopenia-on-overall-survival-in-older-adults-undergoing-different-treatment-pathways-for-pancreatic-cancer
#8
Andrew J Benjamin, Mary M Buschmann, Shuang Qin Zhang, Kristen Wroblewski, Hedy L Kindler, Kevin K Roggin, William Dale
OBJECTIVE: Sarcopenia is associated with poor outcomes in patients undergoing surgery for pancreatic ductal adenocarcinoma (PDAC). However, few studies have assessed changes in sarcopenia during multimodality therapy or its effect on overall survival (OS). METHODS: Computed tomography (CT) total psoas area index (TPAI) and weighted average Hounsfield units (HU) were measured at each treatment interval in patients with resectable PDAC. Four cohorts were compared: 1...
July 2018: Journal of Geriatric Oncology
https://www.readbyqxmd.com/read/29500672/preoperative-detection-of-sarcopenic-obesity-helps-to-predict-the-occurrence-of-gastric-leak-after-sleeve-gastrectomy
#9
Martin Gaillard, Hadrien Tranchart, Sophie Maitre, Gabriel Perlemuter, Panagiotis Lainas, Ibrahim Dagher
BACKGROUND: Sleeve gastrectomy (SG) has become the primary procedure for many bariatric teams and staple-line leak represents its most feared complication. Sarcopenic obesity combines the risks of obesity and depleted lean mass leading possibly to an inferior surgical outcome after abdominal surgery. OBJECTIVES: The aim of this study was to evaluate the existence of a potential link between radiologically determined sarcopenic obesity and staple-line leak risk after SG...
August 2018: Obesity Surgery
https://www.readbyqxmd.com/read/29435297/a-low-psoas-muscle-volume-predicts-longer-hospitalization-and-cancer-recurrence-in-upper-urinary-tract-urothelial-carcinoma
#10
Sohgo Tsutsumi, Takashi Kawahara, Jun-Ichi Teranishi, Masahiro Yao, Hiroji Uemura
The aging population is becoming a primary global problem. The most important alteration that occurs in the body with age, is the loss of skeletal muscle. Previously, sarcopenia, which is associated with the loss of skeletal muscle, has been reported to be associated with the prognosis of cancer and complications. The present study investigated the importance of sarcopenia with regard to the prognosis or postoperative complications of upper urothelial cancer patients who underwent nephro-ureterectomy. A total of sixty patients (male, n=44; female, n=16) underwent nephro-ureterectomy for upper urothelial carcinoma...
February 2018: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/29417591/clinically-practical-approach-for-screening-of-low-muscularity-using-electronic-linear-measures-on-computed-tomography-images-in-critically-ill-patients
#11
Egor Avrutin, Lesley L Moisey, Roselyn Zhang, Jenna Khattab, Emma Todd, Tahira Premji, Rosemary Kozar, Daren K Heyland, Marina Mourtzakis
BACKGROUND: Computed tomography (CT) scans performed during routine hospital care offer the opportunity to quantify skeletal muscle and predict mortality and morbidity in intensive care unit (ICU) patients. Existing methods of muscle cross-sectional area (CSA) quantification require specialized software, training, and time commitment that may not be feasible in a clinical setting. In this article, we explore a new screening method to identify patients with low muscle mass. METHODS: We analyzed 145 scans of elderly ICU patients (≥65 years old) using a combination of measures obtained with a digital ruler, commonly found on hospital radiological software...
July 2018: JPEN. Journal of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/29300439/quantifying-sarcopenia-reference-values-using-lumbar-and-thoracic-muscle-areas-in-a-healthy-population
#12
B A Derstine, S A Holcombe, R L Goulson, B E Ross, N C Wang, J A Sullivan, G L Su, S C Wang
BACKGROUND: Sarcopenia is defined as the loss of skeletal muscle mass and function associated with aging. Muscle mass can be reliably and accurately quantified using clinical CT scans but reference measurements are lacking, particularly in healthy US populations. METHODS: Two-phase CT scans from healthy kidney donors (age 18-40) at the University of Michigan between 1999-2010 were utilized. Muscle mass was quantified using two thoracic and two lumbar muscle cross-sectional area (CSA) measures...
2017: Journal of Nutrition, Health & Aging
https://www.readbyqxmd.com/read/29299352/a-semi-automated-assessment-of-sarcopenia-using-psoas-area-and-density-predicts-outcomes-after-pancreaticoduodenectomy-for-pancreatic-malignancy
#13
Jukes P Namm, Kiran H Thakrar, Chi-Hsiung Wang, Susan J Stocker, Malini D Sur, Jonathan Berlin, William Dale, Mark S Talamonti, Kevin K Roggin
Background: Sarcopenia has been associated with increased adverse outcomes after major abdominal surgery. Sarcopenia defined as decreased muscle volume or increased fatty infiltration may be a proxy for frailty. In conjunction with other preoperative clinical risk factors, radiographic measures of sarcopenia using both muscle size and density may enhance prediction of outcomes after pancreaticoduodenectomy (PD) for malignancy. Methods: Preoperative computed tomography (CT) scans of patients undergoing PD for malignancy were analyzed from a prospective pancreatic surgery database...
December 2017: Journal of Gastrointestinal Oncology
https://www.readbyqxmd.com/read/29276105/grip-strength-measurement-for-frailty-assessment-in-patients-with-vascular-disease-and-associations-with-comorbidity-cardiac-risk-and-sarcopenia
#14
Thomas E Reeve, Rebecca Ur, Timothy E Craven, James H Kaan, Matthew P Goldman, Matthew S Edwards, Justin B Hurie, Gabriela Velazquez-Ramirez, Matthew A Corriere
OBJECTIVE: Frailty is associated with adverse events, length of stay, and nonhome discharge after vascular surgery. Frailty measures based on walking-based tests may be impractical or invalid for patients with walking impairment from symptoms or sequelae of vascular disease. We hypothesized that grip strength is associated with frailty, comorbidity, and cardiac risk among patients with vascular disease. METHODS: Dominant hand grip strength was measured during ambulatory clinic visits among patients with vascular disease (abdominal aortic aneurysm [AAA], carotid stenosis, and peripheral artery disease [PAD])...
May 2018: Journal of Vascular Surgery
https://www.readbyqxmd.com/read/29234981/sarcopenia-after-induction-therapy-in-childhood-acute-lymphoblastic-leukemia-its-clinical-significance
#15
Daisuke Suzuki, Ryoji Kobayashi, Hirozumi Sano, Daiki Hori, Kunihiko Kobayashi
Muscle weakness is one of the most serious problems during chemotherapy for childhood hematological malignancies. It may be caused by long-term hospitalization, unfavorable physical conditions, and restricted activities. Although the concept of sarcopenia is becoming widely recognized, especially in geriatric medicine, there have been few reports about sarcopenia in pediatric patients with hematological malignancies. A total of 47 consecutive first-onset acute lymphoblastic leukemia (ALL) patients who underwent induction therapy between January 2011 and September 2016 were investigated...
April 2018: International Journal of Hematology
https://www.readbyqxmd.com/read/29184684/impact-of-sarcopenia-on-outcomes-of-locally-advanced-esophageal-cancer-patients-treated-with-neoadjuvant-chemoradiation-followed-by-surgery
#16
Gilbert Z Murimwa, Puja S Venkat, William Jin, Susan Leuthold, Kujtim Latifi, Khaldoun Almhanna, Jose M Pimiento, Jacques-Pierre Fontaine, Sarah E Hoffe, Jessica M Frakes
Background: Sarcopenia is an independent predictor of clinical outcomes in multiple gastrointestinal cancers. Total psoas area (TPA), as measured on a single cross-sectional CT image at the L4 vertebral body level, has been correlated with sarcopenia. We sought to evaluate whether TPA was predictive of acute grade ≥3 toxicity, pathologic response, and overall survival in patients with locally advanced esophageal cancer receiving tri-modality therapy. Methods: An institutional database of esophageal cancer patients treated with neoadjuvant chemoradiation followed by surgery was queried...
October 2017: Journal of Gastrointestinal Oncology
https://www.readbyqxmd.com/read/29098519/significance-of-sarcopenia-as-a-prognostic-factor-for-metastatic-urothelial-carcinoma-patients-treated-with-systemic-chemotherapy
#17
Hideyuki Abe, Kohei Takei, Toshitaka Uematsu, Yuumi Tokura, Issei Suzuki, Kazumasa Sakamoto, Daisaku Nishihara, Yoshiyuki Yamaguchi, Tomoya Mizuno, Akinori Nukui, Minoru Kobayashi, Takao Kamai
BACKGROUND: Recently, numerous studies have reported an association between sarcopenia and poor outcomes in various kinds of malignancies. We investigated whether sarcopenia predicts the survival of patients with metastatic urothelial carcinoma who underwent systemic chemotherapy. METHODS: We reviewed 87 metastatic urothelial carcinoma patients who underwent chemotherapy (gemcitabine plus cisplatin or gemcitabine plus carboplatin for cisplatin-unfit patients) between 2007 and 2015...
April 2018: International Journal of Clinical Oncology
https://www.readbyqxmd.com/read/29065187/prognostic-value-of-sarcopenia-in-patients-with-liver-cirrhosis-a-systematic-review-and-meta-analysis
#18
REVIEW
Gaeun Kim, Seong Hee Kang, Moon Young Kim, Soon Koo Baik
BACKGROUND: Sarcopenia is a common syndrome in chronic diseases such as liver cirrhosis. The association between sarcopenia and outcomes, such as complications and survival has recently been described in various patient groups. However, study results remain inconclusive. Therefore, the aim of this study was to systematically review the impact of sarcopenia on outcome in patients with cirrhosis. METHODS AND FINDINGS: We conducted a systematic review (SR) and meta-analysis (MA) on the impact of sarcopenia on outcome in liver cirrhosis was performed according to the Preferred Reporting Items for Systematic Reviews and Meta-Analysis guidelines...
2017: PloS One
https://www.readbyqxmd.com/read/28923108/a-low-psoas-muscle-volume-correlates-with-a-longer-hospitalization-after-radical-cystectomy
#19
Yoko Saitoh-Maeda, Takashi Kawahara, Yasuhide Miyoshi, Sohgo Tsutsumi, Daiji Takamoto, Kota Shimokihara, Yuutaro Hayashi, Taku Mochizuki, Mari Ohtaka, Manami Nakamura, Yusuke Hattori, Jun-Ichi Teranishi, Yasushi Yumura, Kimito Osaka, Hiroki Ito, Kazuhide Makiyama, Noboru Nakaigawa, Masahiro Yao, Hiroji Uemura
BACKGROUND: Recently, sarcopenia has been reported as a new predictor for patient outcomes or likelihood of post-operative complications. The purpose of this study was to evaluate the association of the psoas muscle volume with the length of hospitalization among patients undergoing radical cystectomy. METHODS: A total of 63 (80.8%) male patients and 15 (19.2%) female patients who underwent radical cystectomy for their bladder cancer in our institution from 2000 to 2015 were analyzed...
September 18, 2017: BMC Urology
https://www.readbyqxmd.com/read/28850803/high-serum-essential-amino-acids-as-a-predictor-of-skeletal-muscle-depletion-in-patients-with-cachexia-and-advanced-gastrointestinal-cancers
#20
Moeko Kitagawa, Seiji Haji, Teruyoshi Amagai
BACKGROUND: In recent years, the number of patients with cancer has increased. These patients are prone to sarcopenia as a result of the decrease in muscle mass and muscle weakness that occur in cancer cachexia. Amino Index Cancer Screening is carried out to evaluate cancer cachexia risk by examining amino acid concentration and analyzing amino acid balance. METHODS: We conducted a retrospective chart review of consecutive patients with unresectable advanced gastrointestinal cancer (stage IV) receiving chemotherapy treatment (December 2012-September 2015) in an outpatient or in-hospital setting at our institution (N = 46)...
October 2017: Nutrition in Clinical Practice
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