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Man Zhu, Yuxin Cui, Liu Yang, Tianfeng Yang, Hongying Wang, Dongdong Zhang, Weina Ma, Yanmin Zhang
Erythropoietin-producing hepatocyte B4 (EphB4) has recently been reported to be an oncogenic factor in many cancers and overexpressed in several types of tumors. Thus, EphB4 has the potential to be a therapeutic target in these malignancies. High-performance affinity chromatography has been a powerful tool to study the interaction between drugs and receptors. In this study, we constructed a novel EphB4 affinity chromatography model to investigate the active compounds which can target EphB4. More than 50 crude extracts of traditional Chinese medicine were screened by this affinity chromatography model...
December 4, 2018: Journal of Chromatography. A
Nausheen Nazir, Muhammad Zahoor, Mohammad Nisar, Imran Khan, Nasiara Karim, Heba Abdel-Halim, Akhtar Ali
BACKGROUND: The fruit of Elaeagnus umbellata has high medicinal values and is an excellent source of phytochemicals. This study was aimed to evaluate the antioxidant, enzyme inhibitory and antidiabetic potential of Elaeagnus umbellata. METHODS: The antioxidant potential of the crude extract and subfractions of E. umbellata fruit were determined using DPPH (2, 20-diphenyl-1-picrylhydrazyl) and ABTS (2, 2'-azinobis-3-ethylbenzothiazoline-6-sulfonic acid) assays. The enzyme inhibitory potentials of extracts against α-amylase and α-glucosidase enzymes were also determined...
December 13, 2018: BMC Complementary and Alternative Medicine
Pamela J Surkan, Donna M Strobino, Sucheta Mehra, Abu Ahmed Shamim, Mahbubur Rashid, Lee Shu-Fune Wu, Hasmot Ali, Barkat Ullah, Alain B Labrique, Rolf D W Klemm, Keith P West, Parul Christian
BACKGROUND: Little is known about the relation between unwanted pregnancy and intention discordance and maternal mental health in low-income countries. The study aim was to evaluate maternal and paternal pregnancy intentions (and intention discordance) in relation to perinatal depressive symptoms among rural Bangladeshi women. METHODS: Data come from a population-based, community trial of married rural Bangladeshi women aged 13-44. We examined pregnancy intentions among couples and pregnancy-intention discordance, as reported by women at enrollment soon after pregnancy ascertainment, in relation to depressive symptoms in the third trimester of pregnancy (N = 14,629) and six months postpartum (N = 31,422)...
December 13, 2018: BMC Pregnancy and Childbirth
Zichao Wang, Peizhang Chen, Ning Tao, Huiru Zhang, Ruifang Li, Xiaobei Zhan, Fuzhuan Wang, Yingben Shen
Two polysaccharides were produced by Chaetomium globosum CGMCC 6882 from glycerol (GCP-1) and crude glycerol (GCP-2). Chemical characteristics results showed GCP-1 and GCP-2 were similar polysaccharides, but the molecular weights of GCP-1 and GCP-2 were 5.340 × 10⁴ Da and 3.105 × 10⁴ Da, respectively. Viabilities of A549 cells after treatment with GCP-1 and GCP-2 were 49% and 39% compared to the control group. Meanwhile, flow cytometry results indicated that GCP-1 and GCP-2 could induce 17.79% and 24...
December 11, 2018: Biomolecules
Min-Kyeong Lee, Jeong-Wook Choi, Youn Hee Choi, Taek-Jeong Nam
Glucocorticoids (GCs), which are endocrine hormones released under stress conditions, can cause skeletal muscle atrophy. This study investigated whether Pyropia yezoensis crude protein (PYCP) inhibits synthetic GCs dexamethasone (DEX)-induced myotube atrophy associated with proteolytic systems. Mouse skeletal muscle C2C12 myotubes were treated with DEX in the presence or absence of PYCP. DEX exposure (100 μM) for 24 h significantly decreased myotube diameter and myogenin expression, which were all increased by treatment with 20 and 40 μg/mL PYCP...
December 8, 2018: Marine Drugs
Ali Medbouhi, Aura Tintaru, Claire Beaufay, Jean-Valère Naubron, Nassim Djabou, Jean Costa, Joëlle Quetin-Leclercq, Alain Muselli
The chemical composition of a hexanic extract of Eryngium campestre , obtained from its aerial parts, was investigated by GC-FID, GC/MS, HRMS, NMR and VCD analyses. The main compounds were germacrene D (23.6%), eudesma-4(15)-7-dien-1-β-ol (8.2%) and falcarindiol (9.4%), which are associated with a new uncommon and naturally found 17-membered ring lactone. This 17-membered ring features conjugated acetylenic bonds, named campestrolide (23.0%). The crude extract showed moderate antitrypanosomal ( Trypanosoma brucei brucei ), antileishmanial ( Leishmania mexicana mexicana ) and anticancer (cancerous macrophage-like murine cells) activities, and also displayed cytotoxicity, (human normal fibroblasts) in similar concentration ranges (IC50 = 3...
December 8, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
Rafa S Almeer, Doaa Soliman, Rami B Kassab, Gadah I AlBasher, Saud Alarifi, Saad Alkahtani, Daoud Ali, Dina Metwally, Ahmed E Abdel Moneim
The current study examined the efficacy of royal jelly (RJ) against cadmium chloride (CdCl₂)-induced testicular dysfunction. A total of 28 Swiss male mice were allocated into four groups (n = 7), and are listed as follows: (1) the control group, who was intraperitoneally injected with physiological saline (0.9% NaCl) for 7 days; (2) the RJ group, who was orally supplemented with RJ (85 mg/kg daily equivalent to 250 mg crude RJ) for 7 days; (3) the CdCl₂ group, who was intraperitoneally injected with 6.5 mg/kg for 7 days; and (4) the fourth group, who was supplemented with RJ 1 h before CdCl₂ injection for 7 days...
December 10, 2018: International Journal of Molecular Sciences
Masataka Sunagawa, Kojiro Yamaguchi, Mana Tsukada, Nachi Ebihara, Hideshi Ikemoto, Tadashi Hisamitsu
Stomatitis is occasionally multiple, recurrent, and refractory. Currently, mucositis induced by chemotherapy and radiation therapy in patients with cancer has become a significant clinical problem. Effective treatments have not been established and the treatment of numerous cases remains a challenge for physicians. Traditional Japanese herbal medicines termed Kampo formulae (i.e., Hangeshashinto, Orengedokuto, Inchinkoto, Orento, Byakkokaninjinto, Juzentaihoto, Hochuekkito, and Shosaikoto) are used for treating various types of stomatitis and mucositis...
December 10, 2018: Medicines (Basel, Switzerland)
Yi Zhang, Jing Gao, Qiao Zhang, Kan Wang, Weifeng Yao, Beihua Bao, Li Zhang, Yuping Tang
Euphorbia kansui stir-fried with vinegar (V-kansui) has promising biological activities toward treating malignant ascites with reduced toxicity compared to crude kansui. But the mechanism concerning promoting the excretion of ascites has not been systematically studied. The purpose of this paper was to investigate the possible mechanism of V-kansui in treating malignant ascites, including metabolic pathways and molecular mechanism using an integrated serum and urine metabolomics coupled with network pharmacology...
December 7, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
(no author information available yet)
OBJECTIVEPrevious Japanese Leksell Gamma Knife Society studies (JLGK0901) demonstrated the noninferiority of stereotactic radiosurgery (SRS) alone as the initial treatment for patients with 5-10 brain metastases (BMs) compared with those with 2-4 BMs in terms of overall survival and most secondary endpoints. The authors studied the aforementioned treatment outcomes in a subset of patients with BMs from non-small cell lung cancer (NSCLC).METHODSPatients with initially diagnosed BMs treated with SRS alone were enrolled in this prospective observational study...
December 1, 2018: Journal of Neurosurgery
Keren Agay-Shay, Yaron Michael, Xavier Basagaña, Èrica Martínez-Solanas, David Broday, Itamar M Lensky, Mary Rudolf, Lisa Rubin, Rafi Kent, Nadav Levy, Ziona Haklai, Itamar Grotto
Background: Natural environments may have beneficial impacts on pregnancy outcomes. However, longitudinal evidence is limited and the associations with variance in surrounding greenness is unknown. Our objective was to evaluate these associations among 73 221 live births in Tel Aviv, Israel. Methods: Longitudinal exposure to mean of greenness during pregnancy and trimesters were calculated using satellite-based Moderate Resolution Imaging Spectroradiometer (MODIS) Normalised Difference Vegetation Index (NDVI) data...
December 13, 2018: International Journal of Epidemiology
Janice Dahmer, Gabriele do Carmo, Marco Aurélio Mostardeiro, Alexandre Tibursky Neto, Ubiratan Flores da Silva, Ionara Irion Dalcol, Ademir Farias Morel
ETHNOPHARMACOLOGY RELEVANCE: Discaria americana Gillies ex Hook (sin. Discaria febrifuga and Discaria longispina) (Rhamnaceae) is a plant native from Rio Grande do Sul (Southern Brazil), Uruguay and Argentine, and has been used in Brazilian traditional medicine as antipyretic agent, and for stomach disorders. In Rio Grande do Sul, Uruguay and Argentine, the roots, in decoction, are used as tonic and febrifuge. Although it is a plant widely used by the population, there are no studies proving this popular use...
December 10, 2018: Journal of Ethnopharmacology
Rui-Qi Yang, Bing-Lin Zhang, Hai-Li Sun, Gao-Sen Zhang, Shi-Weng Li, Guang-Xiu Liu, Tuo Chen, Yun-Shi Li, Yong-Na Wu, Li-Zhe An, Wei Zhang, Xiu-Kun Wu
A Gram-stain-positive, aerobic, non-motile and mycolic-acid-containing strain, designated Y48T , was isolated from soil contaminated by crude oil located in the northern margin of the Qaidam Basin. Phylogenetic analysis based on 16S rRNA gene sequences revealed that strain Y48T belongs to the genus Nocardia and is closely related to N. cummidelens DSM 44490T (99.0 % similarity), N. soli DSM 44488T (99.0 %), N. lasii 3C-HV12T (98.9 %), N. salmonicida NBRC 13393T (98.6 %), N. ignorata NBRC 108230T (98...
December 13, 2018: International Journal of Systematic and Evolutionary Microbiology
M Dhaneesha, O Hasin, K C Sivakumar, R Ravinesh, C Benjamin Naman, S Carmeli, T P Sajeevan
A sponge-associated actinomycete (strain MCCB267) was isolated from a marine sponge Mycale sp. collected in the Indian Ocean off the Southeast coast of India. Phylogenetic studies of this strain using 16S rRNA gene sequencing showed high sequence similarity to Streptomyces zhaozhouensis. However, strain MCCB267 showed distinct physiological and biochemical characteristic features and was thus designated as S. zhaozhouensis subsp. mycale. subsp. nov. A cytotoxicity-guided fractionation of the crude ethyl acetate extract of strain MCCB267 culture medium yielded four pure compounds belonging to the polycyclic tetramate macrolactam (PTM) family of natural products: ikarugamycin (IK) (1), clifednamide A (CF) (2), 30-oxo-28-N-methylikarugamycin (OI) (3), and 28-N-methylikarugamycin (MI) (4)...
December 13, 2018: Marine Biotechnology
Amer Jamal Hashmat, Muhammad Afzal, Kaneez Fatima, Muhammad Anwar-Ul-Haq, Qaiser Mahmood Khan, Carlos A Arias, Hans Brix
Ten plant species were grown in constructed wetlands (CWs) to remediate water containing 2% (w/v) crude oil. The plant species with better growth and biomass production were Typha latifolia and Cyperus laevigatus, and they were significantly correlated (R2  = 0.91) with hydrocarbon degradation. From T. latifolia and C. laevigatus, 33 hydrocarbon-degrading bacterial strains were isolated from the rhizosphere, and root and shoot interiors. More diversified bacteria were found in the rhizosphere and endosphere of C...
December 12, 2018: Bulletin of Environmental Contamination and Toxicology
Su Liu, Yunzong Huang, Chuangli Wang, Shoujing Tian, Youjia Xu, Jianfei Ge
The effect of epimedium extracting solution on bone mineral density (BMD) of steroid-induced avascular necrosis of femoral head (SANFH) in rats was evaluated to further explore its function mechanism. Twenty-four Sprague-Dawley (SD) rats (male/female: 1/1) were randomly divided into three groups: the control (n=8), the glucocorticoid (n=8) and the epimedium (n=8) group. Rats in the glucocorticoid and the epimedium group were injected with prednisolone acetate injection in gluteal muscles with 15 mg/kg/day twice a week...
December 2018: Experimental and Therapeutic Medicine
Snigdha Rai, Stefan Lucius, Ramona Kern, Hermann Bauwe, Aaron Kaplan, Joachim Kopka, Martin Hagemann
Photorespiratory phosphoglycolate (2PG) metabolism is essential for cyanobacteria, algae, and plants. The first enzyme of the pathway, 2PG phosphatase (PGPase), is known from plants and algae but was scarcely investigated in cyanobacteria. In silico analysis revealed four candidate genes ( slr0458 , slr0586 , sll1349 , and slr1762 ) in the genome of the model cyanobacterium Synechocystis sp. PCC 6803 that all belong to the 2-haloacid dehalogenase (HAD) superfamily and could possibly encode PGPase proteins. However, in contrast to known algal and plant PGPases, the putative cyanobacterial PGPases belong to another HAD subfamily implying that PGPases in eukaryotic phototrophs did not originate from cyanobacterial PGPases...
2018: Frontiers in Plant Science
Naoka Matsuda, Shunsuke Murata, Rei Ono
AIM: To examine the association between health literacy (HL) and life space in community-dwelling older adults. METHODS: In this cross-sectional study, we analyzed 210 community-dwelling older adults (mean age: 74.6 years, women: 63.8%). Health literacy was measured using the 14-item Health Literacy Scale (HLS-14). The 14 items consist of 5 items for functional HL (FHL), 5 items for interactive HL (CHL), and 4 items for critical HL (IHL). We calculated the total score, FHL score, CHL score, and IHL score...
2018: Nihon Ronen Igakkai Zasshi. Japanese Journal of Geriatrics
Kazuki Uemura, Minoru Yamada, Masafumi Kuzuya, Hiroshi Okamoto
AIM: This study aimed to investigate the effects of limited health literacy on arterial stiffness measured by the cardio-ankle vascular index (CAVI) in community-dwelling older adults. METHODS: A total of 288 older adults (mean age, 72.4 years, men, n = 99) participated. The degree of arterial stiffness was assessed based on the CAVI using the VS-1500 device (Fukuda Denshi Co., Ltd., Tokyo, Japan). Arterial stiffness was defined according to a cut-off point of ≥9...
2018: Nihon Ronen Igakkai Zasshi. Japanese Journal of Geriatrics
Junmin Ji, Zhengfa Ge, Yeshen Feng, Xuede Wang
To develop and use the hazelnut, the main composition, and the physicochemical characteristics, fatty acid compositions, triacylglycerol (TAG) distribution and tocol contents of Hazelnut (Corylus mandshurica Maxim.) which growing in Changbai mountain of Jilin province (HO1) and Anshan city of Liaoning province (HO2) in China were investigated, and the comparative study between the two hazelnut oils and American hazelnut / Turkish hazelnut were also explored. The content of crude lipid and protein in HO1 and HO2 were approximately 54% and 17%, 55% and 16%, respectively...
December 12, 2018: Journal of Oleo Science
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