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Prosthetic AND Joint AND infection

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https://www.readbyqxmd.com/read/30547120/comparison-of-implant-survivability-in-primary-1-to-2-level-lumbar-fusion-amongst-opioid-abusers-and-non-opioid-abusers
#1
Rushabh M Vakharia, Chester J Donnally, Augustus J Rush, Ajit M Vakharia, Derek D Berglund, Neil V Shah, Michael Y Wang
Background: Primary lumbar fusion (LF) is a treatment option for degenerative disc disease. The literature is limited regarding postoperative complications in opioid abusers undergoing LF. The purpose of this study was to compare 2-year short term implant-related complications, infection rates, 90-day readmission rates, in-hospital length of stay, and cost of care amongst opioid abusers (OAS) and non-opioid abusers (NAS) undergoing primary 1- to 2-level primary lumbar fusion (1-2LF). Methods: A retrospective review was performed using the Medicare Standard Analytical Files from an administrative database...
September 2018: Journal of Spine Surgery (Hong Kong)
https://www.readbyqxmd.com/read/30545655/is-operative-time-a-predictor-for-post-operative-infection-in-primary-total-knee-arthroplasty
#2
Hiba K Anis, Nipun Sodhi, Alison K Klika, Michael A Mont, Wael K Barsoum, Carlos A Higuera, Robert M Molloy
BACKGROUND: The purpose of this study is to identify factors affecting operative times and to evaluate the associations of operative times with prosthetic joint infections (PJIs) and surgical site infections (SSIs) in primary total knee arthroplasty. METHODS: A total of 11,840 primary total knee arthroplasties with a mean 2-year post-operative follow-up were studied. Operative times were analyzed both as categorical and continuous variables. Associations with PJIs and SSIs were evaluated with univariate and multivariate analyses to adjust for gender, age, body mass index, Charlson Comorbidity Index, year of surgery, antibiotic cement use, and hospital/surgeon volume...
November 22, 2018: Journal of Arthroplasty
https://www.readbyqxmd.com/read/30543660/lbl-assembled-gentamicin-delivery-system-for-pmma-bone-cements-to-prolong-antimicrobial-activity
#3
Yazan Al Thaher, Lirong Yang, Steve A Jones, Stefano Perni, Polina Prokopovich
INTRODUCTION: Antibiotic-loaded poly(methyl methacrylate) bone cements (ALBCs) are widely used in total joint replacement (TJR), for local delivery of antibiotics to provide prophylaxis against prosthetic joint infections (PJI). One of the shortcomings of the current generation of ALBCs is that the antibiotic release profile is characterized by a burst over the first few hours followed by a sharp decrease in rate for the following several days (often below minimum inhibitory concentration (MIC)), and, finally, exhaustion (after, typically, ~ 20 d)...
2018: PloS One
https://www.readbyqxmd.com/read/30541933/sonication-culture-of-antimicrobial-agent-containing-cement-spacers-removed-during-staged-revisions-for-arthroplasty-infection
#4
Eric Gomez-Urena, Rafael J Sierra, Kerryl E Greenwood-Quiantance, Melissa J Karau, James M Steckelberg, Robin Patel
Diagnosis of persistent infection at the time of reimplantation for staged revision of infected arthroplasties is challenging. Implant sonication culture for the diagnosis of prosthetic joint infection (PJI) has improved sensitivity compared to standard periprosthetic tissue culture. We report our experience with periprosthetic tissue culture and sonication culture of antimicrobial agent-containing cement spacers (ACSs) collected during second stages of staged revisions for arthroplasty infection. We studied 87 ACSs from 66 patients undergoing two-stage revision arthroplasty for PJI submitted for sonication culture along with conventional periprosthetic tissue cultures...
December 12, 2018: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/30538688/bone-environment-influences-irreversible-adhesion-of-a-methicillin-susceptible-staphylococcus-aureus-strain
#5
Fany Reffuveille, Jérôme Josse, Frédéric Velard, Fabien Lamret, Jennifer Varin-Simon, Marie Dubus, Evan F Haney, Robert E W Hancock, Céline Mongaret, Sophie C Gangloff
Prosthesis and joint infections are an important threat in public health, especially due to the development of bacterial biofilms and their high resistance to antimicrobials. Biofilm-associated infections increase mortality and morbidity rates as well as hospitalization costs. Prevention is the best strategy for this serious issue, so there is an urgent need to understand the signals that could induce irreversible bacterial adhesion on a prosthesis. In this context, we investigated the influence of the bone environment on surface adhesion by a methicillin-susceptible Staphylococcus aureus strain...
2018: Frontiers in Microbiology
https://www.readbyqxmd.com/read/30533346/economic-analysis-in-a-diagnosis-related-groups-system-for-two-stage-exchange-of-prosthetic-joint-infections
#6
Arnaud Fischbacher, Karine Peltier, Olivier Borens
Background: There is a constant increase of joint arthroplasties performed, with an infectious risk of 1-2%. Different therapeutic options for prosthetic-joint infections exist, but surgery remains essential. With a two-stage exchange procedure, a success rate above 90% can be expected. Currently, there is no consensus regarding the optimal interval duration between explantation and reimplantation. This retrospective study aimed to assess the economic impact of a two-stage exchange from a single-hospital perspective...
2018: Journal of Bone and Joint Infection
https://www.readbyqxmd.com/read/30533345/accuracy-of-synovial-leukocyte-and-polymorphonuclear-cell-count-in-patients-with-shoulder-prosthetic-joint-infection
#7
Carol Strahm, Vilijam Zdravkovic, Claus Egidy, Bernhard Jost
Joint aspiration in suspected infected implants is a validated diagnostic method in establishing the diagnosis of prosthetic joint infection (PJI). Cut-off values for synovial leukocyte counts and differentials are well described for patients with hip and knee PJI. In 19 failed shoulder implants, a leucocyte count of >12.2 G/L had a sensitivity and specificity of 92% and 100% respectively; A differential of >54% neutrophils had a sensitivity of 100 % and a specificity of 75%.
2018: Journal of Bone and Joint Infection
https://www.readbyqxmd.com/read/30533344/totally-implantable-venous-access-device-infection-causing-hematogenous-prosthetic-joint-infection-a-retrospective-case-series
#8
Fernanda Medina, Vanina Meyssonnier, Valérie Zeller, Beate Heym, Jean-Marc Ziza, Simon Marmor
Introduction: Prosthetic joint infections (PJIs) can be acquired hematogenously from a distant site or device. Notably, 30%-40% of patients with PJIs have Staphylococcus aureus bacteremia. No case reports or series of PJIs acquired from totally implantable venous-access device (TIVAD) infection or colonization have been published. This study was undertaken to describe epidemiological, clinical, microbiological and radiological characteristics of such PJIs, their treatments and outcomes. Methods: This retrospective study included all patients, identified in a prospective French Bone-and-Joint Infections Referral Center cohort treated between 2004 and 2017, with PJI secondary to TIVAD infection, with the same microbiologically documented microorganism isolated from both...
2018: Journal of Bone and Joint Infection
https://www.readbyqxmd.com/read/30516626/the-effect-of-prosthetic-design-and-polyethylene-type-on-the-risk-of-revision-for-infection-in-total-knee-replacement-an-analysis-of-336-997-prostheses-from-the-australian-orthopaedic-association-national-joint-replacement-registry
#9
Christopher J Vertullo, Richard N de Steiger, Peter L Lewis, Michelle Lorimer, Yi Peng, Stephen E Graves
BACKGROUND: Periprosthetic infection following total knee replacement remains alarmingly frequent, is devastating for patients, and is an increasingly substantial public health burden. While both the prosthetic design elements and type of polyethylene used in total knee replacement can independently affect survivorship of the prosthesis, their influence on the risk of revision for infection is unknown. Therefore, we examined the effects of total knee prosthetic design and type of polyethylene bearing on the long-term revision risk for nonacute infection following total knee replacement by comparing 4 different cohorts: patients who had minimally stabilized total knee prostheses with crosslinked polyethylene (XLPE) bearing surfaces, minimally stabilized total knee prostheses with noncrosslinked polyethylene (NXLPE), posterior stabilized total knee prostheses with XLPE, and posterior stabilized total knee prostheses with NXLPE...
December 5, 2018: Journal of Bone and Joint Surgery. American Volume
https://www.readbyqxmd.com/read/30502487/are-coagulase-negative-staphylococci-virulent
#10
REVIEW
Christine Heilmann, Wilma Ziebuhr, Karsten Becker
BACKGROUND: Progress in contemporary medicine is associated with an increasing number of immunocompromised individuals. In this vulnerable group, the underlying disease together with long-term hospitalization and the use of medical devices facilitate infections by opportunistic pathogens for which coagulase-negative staphylococci (CoNS) represent a prime example. OBJECTIVES: The diversity of CoNS with species- and strain-specific differences concerning virulence and clinical impact is highlighted...
November 28, 2018: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/30501477/incidence-and-risk-factors-for-dental-pathology-in-patients-planned-for-elective-total-hip-or-knee-arthroplasty
#11
M Vuorinen, T Mäkinen, M Rantasalo, J Leskinen, H Välimaa, K Huotari
BACKGROUND AND AIMS: To prevent severe prosthetic joint infections, a dental examination is usually recommended prior to arthroplasty, even sometimes regarded resource- and time-consuming. The aim of this study was to determine whether a risk factor-based algorithm could be created to send only selected patients for dental clearance. MATERIALS AND METHODS: A prospective study of 952 patients scheduled for elective arthroplasty was performed. Patients filled out a questionnaire regarding potential risk factors for dental infections, and dentists documented patients' oral health and interventions performed (data available for 731 patients)...
December 2, 2018: Scandinavian Journal of Surgery: SJS
https://www.readbyqxmd.com/read/30497094/glove-change-to-reduce-the-risk-of-surgical-site-infection-or-prosthetic-joint-infection-in-arthroplasty-surgeries-a-systematic-review
#12
REVIEW
Katy Kim, Mark Zhu, Jacob T Munro, Simon W Young
BACKGROUND: Microbiological contamination of surgical gloves occurs during surgery, which may warrant glove change during orthopaedic surgeries. However, no systematic review of this topic has previously been published. Therefore, this review evaluated whether changing gloves during arthroplasty surgeries reduces the risk of surgical site infection/prosthetic joint infection (SSI/PJI) and the optimal frequency of glove change. METHODS: Search terms such as surgical gloves, surgical site infections, prosthesis-related infections, arthroplasty were used, including Medical Subject Headings terms...
November 29, 2018: ANZ Journal of Surgery
https://www.readbyqxmd.com/read/30488282/implementation-of-a-multidisciplinary-infections-conference-affects-the-treatment-plan-in-prosthetic-joint-infections-of-the-hip-a-retrospective-study
#13
Dimitris Ntalos, J Berger-Groch, H Rohde, L G Grossterlinden, A Both, A Luebke, M J Hartel, T O Klatte
INTRODUCTION: Establishing a systematic multidisciplinary approach in the treatment of prosthetic joint infections (PJI) of the hip and analyzing its effect on clinical decision-making. PATIENTS AND METHODS: Forty-six patients diagnosed with PJI of the hip were included in the retrospective study. The treatment plan was either established by a single-discipline approach (n = 20) or by a weekly multidisciplinary infections conference (n = 26) consisting of at least an orthopedic surgeon, microbiologist and pathologist...
November 28, 2018: Archives of Orthopaedic and Trauma Surgery
https://www.readbyqxmd.com/read/30485337/surgeons-are-deeply-affected-when-patients-are-diagnosed-with-prosthetic-joint-infection
#14
Charlotte Mallon, Rachael Gooberman-Hill, Ashley Blom, Michael Whitehouse, Andrew Moore
Knee replacement is a common preference sensitive quality-of-life procedure that can reduce pain and improve function for people with advanced knee arthritis. While most patients improve, knee replacement surgery has the potential for serious complications. Prosthetic knee infection is an uncommon but serious complication. This study explored the impact of cases of prosthetic knee infection on surgeons' personal and professional wellbeing. Qualitative telephone interviews were conducted with consultant orthopaedic surgeons who treated patients for prosthetic knee infection in one of six high-volume NHS orthopaedic departments...
2018: PloS One
https://www.readbyqxmd.com/read/30482664/treatment-of-prosthetic-joint-infection-established-patient-relationships-may-impact-medical-decision-making
#15
Sean P Ryan, Tyler J Vovos, Cierra S Hong, Michael A Bergen, Peter M Formby, Michael P Bolognesi, Thorsten M Seyler
BACKGROUND: Choosing the intervention for prosthetic joint infections, whether debridement, antibiotics, and implant retention (DAIR), or explant and antibiotic spacer placement, is multifactorial. One characteristic that may influence this decision is a previously established relationship with the patient. We hypothesized that patients receiving their arthroplasty at an outside institution and presenting with infection would be more likely to undergo removal of their implant without an attempt at DAIR compared to patients who underwent primary arthroplasty at the investigating institution...
October 9, 2018: Journal of Arthroplasty
https://www.readbyqxmd.com/read/30474047/salvage-debridement-antibiotics-and-implant-retention-dair-with-local-injection-of-a-selected-cocktail-of-bacteriophages-is-it-an-option-for-an-elderly-patient-with-relapsing-staphylococcus-aureus-prosthetic-joint-infection
#16
Tristan Ferry, Gilles Leboucher, Cindy Fevre, Yannick Herry, Anne Conrad, Jérôme Josse, Cécile Batailler, Christian Chidiac, Mathieu Medina, S Lustig, Frédéric Laurent
Local injection of a bacteriophages mix during debridement, antibiotics and implant retention ("DAIR") was performed to treat a relapsing Staphylococcus aureus chronic prosthetic joint infection (PJI). This salvage treatment was safe and associated with a clinical success. Scientific evaluation of the potential clinical benefit of bacteriophages as antibiofilm treatment in PJI is now feasible and required.
November 2018: Open Forum Infectious Diseases
https://www.readbyqxmd.com/read/30471785/polymerase-chain-reaction-assay-using-the-restriction-fragment-length-polymorphism-technique-in-the-detection-of-prosthetic-joint-infections-a-multi-centered-study
#17
Ataollah Moshirabadi, Mohammad Razi, Peyman Arasteh, Mohammad Mahdi Sarzaeem, Saman Ghaffari, Saied Aminiafshar, Kami Hosseinian Khosroshahy, Fatemeh Maryam Sheikholeslami
BACKGROUND: PCR-RFLP (polymerase chain reaction-restriction fragment length polymorphism) techniques have been used for the diagnosis of bacteria in some infections. In this study, we aimed to evaluate the diagnostic accuracy of PCR for the diagnosis of prosthetic joint infections (PJI) and to identify isolated microorganisms, using the RFLP method. METHODS: During January 2015 to January 2018, patients who were suspected of having PJI after arthroplasty surgery or were candidates for revision surgery due to loosening of implant entered the study...
October 25, 2018: Journal of Arthroplasty
https://www.readbyqxmd.com/read/30470866/effects-of-vitamin-e-incorporation-in-polyethylene-on-oxidative-degradation-wear-rates-immune-response-and-infections-in-total-joint-arthroplasty-a-review-of-the-current-literature
#18
REVIEW
Bart Lambert, Daniëlle Neut, Hugo C van der Veen, Sjoerd K Bulstra
Highly cross-linked ultrahigh molecular weight polyethylene (UHMWPE) was introduced to decrease wear debris and osteolysis. During cross-linking, free radicals are formed, making highly cross-linked polyethylene vulnerable to oxidative degradation. In order to reduce this process, anti-oxidant vitamin E can be incorporated in polyethylene. This review provides an overview of the effects of vitamin E incorporation on major complications in total joint arthroplasty: material failure due to oxidative degradation, wear debris and subsequent periprosthetic osteolysis, and prosthetic joint infections...
November 23, 2018: International Orthopaedics
https://www.readbyqxmd.com/read/30467117/optimising-detection-and-prevention-of-prosthetic-joint-infections
#19
Christopher Kandel, Nick Daneman
No abstract text is available yet for this article.
November 22, 2018: BMJ Quality & Safety
https://www.readbyqxmd.com/read/30457550/in-host-adaptation-of-salmonella-enterica-serotype-dublin-during-prosthetic-hip-joint-infection
#20
Faten El Sayed, Guillaume Sapriel, Nizar Fawal, Aurelia Gruber, Thomas Bauer, Beate Heym, Caroline Dupont, Henri-Jean Garchon, Jean-Louis Gaillard, Martin Rottman, Simon Le Hello
Genome degradation has been central to the adaptation of Salmonella enterica serotypes to their hosts throughout evolution. We witnessed the patho-adaptation of a strain of Salmonella Dublin (a cattle-adapted serotype) to a human host during the course of a recurrent prosthetic hip joint infection evolving over several years.
December 2018: Emerging Infectious Diseases
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