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https://www.readbyqxmd.com/read/30518005/-a-multicenter-clinical-study-on-1-138-cases-of-invasive-pneumococcal-disease-in-children-from-2012-to-2017
#1
L Zhu, W H Li, X H Wang, K Tan, Q F Fang, Q X Zhu, K K Wu, Q Z Yang, A W Lin, H L Deng, J Bi, J Liu, S Y Zhao, Y Liu, S J Jing, Y M Wang, L M Li, Q Zhao, K H Yao, X Wang, L Jia, F Wang, J K Deng, J Sun, C H Zhu, K Zhou, J Liang, X Z Nie, S C Cao, D M Wang, S J Li, X X Chen, J Li, Y Wang, L Ye, Y H Zhang, F Dong, Z Li, Y H Yang, G Liu
Objective: To explore the clinical features, the serotype distribution and drug resistance of the isolates in patient with invasive pneumococcal disease (IPD). Methods: By retrieving the laboratory information system in 18 children's hospitals from 2012 to 2017, the children with IPD were enrolled. Streptococcus pneumoniae (Spn) must be isolated from the sterile sites (blood, cerebrospinal fluid, hydrothorax and joint effusion etc.). The clinical characteristics, serotype, drug resistance, treatment and prognosis were reviewed and analyzed...
December 2, 2018: Zhonghua Er Ke za Zhi. Chinese Journal of Pediatrics
https://www.readbyqxmd.com/read/30517641/evaluation-of-the-ability-of-linezolid-and-tedizolid-to-eradicate-intraosteoblastic-and-biofilm-embedded-staphylococcus-aureus-in-the-bone-and-joint-infection-setting
#2
Lélia Abad, Virginie Tafani, Jason Tasse, Jérôme Josse, Christian Chidiac, Sébastien Lustig, Tristan Ferry, Alan Diot, Frédéric Laurent, Florent Valour
Objectives: Prolonged use of linezolid for bone and joint infection (BJI) is limited by its long-term toxicity. The better safety profile of tedizolid, a recently developed oxazolidinone, could offer an alternative. However, its efficacy against biofilm-embedded and intracellular Staphylococcus aureus, the two main bacterial reservoirs associated with BJI chronicity, is unknown. Methods: Using three S. aureus strains (6850 and two clinical BJI isolates), linezolid and tedizolid were compared regarding their ability: (i) to target the S...
December 4, 2018: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/30516637/serum-erythrocyte-sedimentation-rate-and-c-reactive-protein-level-have-weaknesses-but-are-the-best-screening-so-far-commentary-on-an-article-by-michael-m-kheir-md-et-al-routine-diagnostic-tests-for-periprosthetic-joint-infection-demonstrate-a-high-false-negative
#3
https://www.readbyqxmd.com/read/30516629/routine-diagnostic-tests-for-periprosthetic-joint-infection-demonstrate-a-high-false-negative-rate-and-are-influenced-by-the-infecting-organism
#4
Michael M Kheir, Timothy L Tan, Noam Shohat, Carol Foltz, Javad Parvizi
BACKGROUND: Current guidelines recommend serum erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) as the first-line testing for evaluation of suspected periprosthetic joint infection, in addition to synovial white blood-cell (WBC) count and polymorphonuclear percentage. However, the sensitivity and other diagnostic measures of these tests using a standardized definition of periprosthetic joint infection and the influence of organisms on these inflammatory markers remain inadequately investigated...
December 5, 2018: Journal of Bone and Joint Surgery. American Volume
https://www.readbyqxmd.com/read/30516626/the-effect-of-prosthetic-design-and-polyethylene-type-on-the-risk-of-revision-for-infection-in-total-knee-replacement-an-analysis-of-336-997-prostheses-from-the-australian-orthopaedic-association-national-joint-replacement-registry
#5
Christopher J Vertullo, Richard N de Steiger, Peter L Lewis, Michelle Lorimer, Yi Peng, Stephen E Graves
BACKGROUND: Periprosthetic infection following total knee replacement remains alarmingly frequent, is devastating for patients, and is an increasingly substantial public health burden. While both the prosthetic design elements and type of polyethylene used in total knee replacement can independently affect survivorship of the prosthesis, their influence on the risk of revision for infection is unknown. Therefore, we examined the effects of total knee prosthetic design and type of polyethylene bearing on the long-term revision risk for nonacute infection following total knee replacement by comparing 4 different cohorts: patients who had minimally stabilized total knee prostheses with crosslinked polyethylene (XLPE) bearing surfaces, minimally stabilized total knee prostheses with noncrosslinked polyethylene (NXLPE), posterior stabilized total knee prostheses with XLPE, and posterior stabilized total knee prostheses with NXLPE...
December 5, 2018: Journal of Bone and Joint Surgery. American Volume
https://www.readbyqxmd.com/read/30511329/ertapenem-for-osteoarticular-infections-in-obese-patients-a-pharmacokinetic-study-of-plasma-and-bone-concentrations
#6
Jonathan Chambers, Madhu Page-Sharp, Sam Salman, John Dyer, Timothy M E Davis, Kevin T Batty, Laurens Manning
PURPOSE: Ertapenem is used off-label to treat osteoarticular infections but there are few pharmacokinetic (PK) data to guide optimal dosing strategies in patients who may be obese with multiple co-morbidities including diabetes and peripheral vascular disease. METHODS: Participants undergoing lower limb amputation or elective joint arthroplasty received a dose of intravenous ertapenem prior to surgery. Eight plasma samples were collected over 24 h, together with at least one bone sample per patient...
December 4, 2018: European Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/30511272/dengue-and-chikungunya-infections-in-children-guest-editor-bhim-s-pandhi
#7
REVIEW
Nitin Dhochak, Sushil K Kabra, Rakesh Lodha
Dengue and Chikungunya are two important mosquito-borne acute febrile illnesses in children. With increased urbanization and newer strains of chikungunya virus with improved transmission with Aedes albopictus, the at-risk population for these infections has greatly increased. Dengue fever has been classified by WHO as dengue with/ without warning signs and severe dengue. Severe dengue is associated with hemorrhagic manifestations, hypovolemia and hypotension secondary to third space loss due to capillary leak or severe end organ dysfunction...
December 4, 2018: Indian Journal of Pediatrics
https://www.readbyqxmd.com/read/30509263/diversity-analysis-of-msp1-identifies-conserved-epitope-organization-in-block-2-amidst-high-sequence-variability-in-indian-plasmodium-falciparum-isolates
#8
Sharmistha Ghoshal, Pragya Gajendra, Sumana Datta Kanjilal, Mitashree Mitra, Sanghamitra Sengupta
BACKGROUND: Despite its immunogenicity, the polymorphic nature of merozoite surface protein 1, an important vaccine candidate for Plasmodium falciparum malaria, remains a concern. This study analyses the impact of genetic variability and parasite population structure on epitope organization of different MSP1 segments. METHODS: Altogether 98 blood samples collected from P. falciparum infected mild and severe malaria patients of Chhattisgarh and West Bengal were used to sequence regions encoding block 2 and MSP1-19 of msp1...
December 3, 2018: Malaria Journal
https://www.readbyqxmd.com/read/30508936/a-comparison-of-adductor-canal-block-and-femoral-nerve-block-after-total-knee-arthroplasty-regarding-analgesic-effect-effectiveness-of-early-rehabilitation-and-lateral-knee-pain-relief-in-the-early-stage
#9
Zhen Tan, Pengde Kang, FuXing Pei, Bin Shen, ZongKe Zhou, Jing Yang
BACKGROUND: The aim of this study was to compare the analgesic effect on the lateral and overall knee and early rehabilitation between adductor canal block (ACB) and femoral nerve block (FNB) after total-knee arthroplasty. METHOD: Two hundred patients randomly participated in the study and were divided into the ACB group and FNB group in a randomized manner. All patients received standardized anesthesia and analgesia upon hospitalization. Outcome evaluations included visual analog scale (VAS) scores at rest and during activity, quadriceps strength, range of motion (ROM), total opioid consumption and complication occurrence, sleep interruptions caused by pain, postoperative nausea and vomiting (PONV), and postoperative length of stay (PLOS) before discharge in all groups...
November 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/30507831/corr-insights%C3%A2-do-trabecular-metal-acetabular-components-reduce-the-risk-of-rerevision-after-revision-tha-performed-for-periprosthetic-joint-infection-a-study-using-the-njr-data-set
#10
David R Maldonado
No abstract text is available yet for this article.
November 30, 2018: Clinical Orthopaedics and related Research
https://www.readbyqxmd.com/read/30503321/total-hip-arthroplasty-in-human-immunodeficiency-virus-positive-patients-a-concise-follow-up-at-10-to-14-years
#11
David Novikov, Afshin A Anoushiravani, Kevin K Chen, Theodore S Wolfson, Nimrod Snir, Ran Schwarzkopf
BACKGROUND: Advancements in the management of human immunodeficiency virus (HIV) now permit HIV-positive patients to have longer life spans, increasing their cumulative risk of developing an advanced degenerative joint disease, necessitating total hip arthroplasty (THA). The purpose of this study was to provide an extended follow-up on a previously published study on a cohort of HIV-positive THA recipients in an effort to confirm the safety and longevity of THA in this population. METHODS: This study is a follow-up on a previous study comprised of 41 hips in 31 HIV-positive THA recipients...
November 8, 2018: Journal of Arthroplasty
https://www.readbyqxmd.com/read/30502487/are-coagulase-negative-staphylococci-virulent
#12
REVIEW
Christine Heilmann, Wilma Ziebuhr, Karsten Becker
BACKGROUND: Progress in contemporary medicine is associated with an increasing number of immunocompromised individuals. In this vulnerable group, the underlying disease together with long-term hospitalization and the use of medical devices facilitate infections by opportunistic pathogens for which coagulase-negative staphylococci (CoNS) represent a prime example. OBJECTIVES: The diversity of CoNS with species- and strain-specific differences concerning virulence and clinical impact is highlighted...
November 28, 2018: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/30501477/incidence-and-risk-factors-for-dental-pathology-in-patients-planned-for-elective-total-hip-or-knee-arthroplasty
#13
M Vuorinen, T Mäkinen, M Rantasalo, J Leskinen, H Välimaa, K Huotari
BACKGROUND AND AIMS: To prevent severe prosthetic joint infections, a dental examination is usually recommended prior to arthroplasty, even sometimes regarded resource- and time-consuming. The aim of this study was to determine whether a risk factor-based algorithm could be created to send only selected patients for dental clearance. MATERIALS AND METHODS: A prospective study of 952 patients scheduled for elective arthroplasty was performed. Patients filled out a questionnaire regarding potential risk factors for dental infections, and dentists documented patients' oral health and interventions performed (data available for 731 patients)...
December 2, 2018: Scandinavian Journal of Surgery: SJS
https://www.readbyqxmd.com/read/30497094/glove-change-to-reduce-the-risk-of-surgical-site-infection-or-prosthetic-joint-infection-in-arthroplasty-surgeries-a-systematic-review
#14
REVIEW
Katy Kim, Mark Zhu, Jacob T Munro, Simon W Young
BACKGROUND: Microbiological contamination of surgical gloves occurs during surgery, which may warrant glove change during orthopaedic surgeries. However, no systematic review of this topic has previously been published. Therefore, this review evaluated whether changing gloves during arthroplasty surgeries reduces the risk of surgical site infection/prosthetic joint infection (SSI/PJI) and the optimal frequency of glove change. METHODS: Search terms such as surgical gloves, surgical site infections, prosthesis-related infections, arthroplasty were used, including Medical Subject Headings terms...
November 29, 2018: ANZ Journal of Surgery
https://www.readbyqxmd.com/read/30496717/setting-the-scene-setting-the-targets-the-joint-united-nations-programme-on-hiv-aids-prevention-targets-of-2016-and-estimating-global-pre-exposure-prophylaxis-targets
#15
Rosalind Coleman
Commitment to ambitious and time-bound targets for HIV interventions has been part of the response from the beginning of the HIV epidemic. The Joint United Nations Programme on HIV/AIDS (UNAIDS) HIV primary prevention workA is built on five pillars that include offering pre-exposure prophylaxis (PrEP) to population groups at substantial risk of HIV infection. After a slow start, countries are now setting coverage targets for PrEP, but the weakness of epidemiological, demographic and behavioural data at subnational level in many countries where there is a high burden of new HIV infections, makes it difficult to define the locations and populations where to offer PrEP...
November 2018: Sexual Health
https://www.readbyqxmd.com/read/30488282/implementation-of-a-multidisciplinary-infections-conference-affects-the-treatment-plan-in-prosthetic-joint-infections-of-the-hip-a-retrospective-study
#16
Dimitris Ntalos, J Berger-Groch, H Rohde, L G Grossterlinden, A Both, A Luebke, M J Hartel, T O Klatte
INTRODUCTION: Establishing a systematic multidisciplinary approach in the treatment of prosthetic joint infections (PJI) of the hip and analyzing its effect on clinical decision-making. PATIENTS AND METHODS: Forty-six patients diagnosed with PJI of the hip were included in the retrospective study. The treatment plan was either established by a single-discipline approach (n = 20) or by a weekly multidisciplinary infections conference (n = 26) consisting of at least an orthopedic surgeon, microbiologist and pathologist...
November 28, 2018: Archives of Orthopaedic and Trauma Surgery
https://www.readbyqxmd.com/read/30487497/wound-coverage-of-infected-open-fracture-of-distal-third-of-tibia-by-distally-based-medial-hemi-soleus-muscle-flap
#17
M S Islam, M T Hossain, M N Uddin, M R Chowdhury, M S Hasan
We conducted a study to evaluate the reliability of the medial hemi-soleus muscle flap for wound coverage of infected open fracture of distal third of tibia. Wound coverage of exposed lower third tibia and ankle region remains a difficult task. Muscle flaps are preferred for infected wounds especially where there are exposed bone, joint and/or tendons. Soleus muscle is a good option for local reconstruction. Soleus being the prime ankle plantar flexor and stabilizer of the ankle in ambulation cannot be sacrificed without significant morbidity...
October 2018: Mymensingh Medical Journal: MMJ
https://www.readbyqxmd.com/read/30485337/surgeons-are-deeply-affected-when-patients-are-diagnosed-with-prosthetic-joint-infection
#18
Charlotte Mallon, Rachael Gooberman-Hill, Ashley Blom, Michael Whitehouse, Andrew Moore
Knee replacement is a common preference sensitive quality-of-life procedure that can reduce pain and improve function for people with advanced knee arthritis. While most patients improve, knee replacement surgery has the potential for serious complications. Prosthetic knee infection is an uncommon but serious complication. This study explored the impact of cases of prosthetic knee infection on surgeons' personal and professional wellbeing. Qualitative telephone interviews were conducted with consultant orthopaedic surgeons who treated patients for prosthetic knee infection in one of six high-volume NHS orthopaedic departments...
2018: PloS One
https://www.readbyqxmd.com/read/30484853/bone-scintigraphy-a-review-of-technical-aspects-and-applications-in-orthopedic-surgery
#19
John W Krumme, Madelyn F Lauer, Justin T Stowell, Nebiyu M Beteselassie, Suhel Y Kotwal
Due to its high sensitivity, low cost, accessibility, and ease of use, bone scintigraphy is used in orthopedic surgery for the diagnosis and management of varied pathology. It is commonly used for insufficiency fractures, metastatic neoplasia, staging and surveillance of sarcoma, and nonaccidental trauma. It augments diagnoses, including stress or occult fractures, musculoskeletal neoplasia or infection, and chronic regional pain syndrome, in patients presenting with normal results on radiographs. Bone scan images are resistant to metal-based implant artifact, allowing effective evaluation of failed total joint prostheses...
November 26, 2018: Orthopedics
https://www.readbyqxmd.com/read/30482665/cost-effectiveness-of-preoperative-smoking-cessation-interventions-in-total-joint-arthroplasty
#20
Matthew R Boylan, Joseph A Bosco, James D Slover
BACKGROUND: Smoking is associated with adverse outcomes after total joint arthroplasty (TJA), including periprosthetic joint infection (PJI). Although preoperative smoking cessation interventions may help reduce the risk PJI, the short-term cost-effectiveness of these programs remains unclear. METHODS: Decision analysis was used to evaluate the cost-effectiveness of a preoperative smoking cessation intervention over a 90-day TJA episode of care. Costs and probabilities were derived from literature review and published Medicare data...
September 28, 2018: Journal of Arthroplasty
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