keyword
https://read.qxmd.com/read/37977170/short-medium-and-long-deferral-of-umbilical-cord-clamping-compared-with-umbilical-cord-milking-and-immediate-clamping-at-preterm-birth-a-systematic-review-and-network-meta-analysis-with-individual-participant-data
#21
JOURNAL ARTICLE
Anna Lene Seidler, Sol Libesman, Kylie E Hunter, Angie Barba, Mason Aberoumand, Jonathan G Williams, Nipun Shrestha, Jannik Aagerup, James X Sotiropoulos, Alan A Montgomery, Gillian M L Gyte, Lelia Duley, Lisa M Askie
BACKGROUND: Deferred (also known as delayed) cord clamping can improve survival of infants born preterm (before 37 weeks of gestation), but the optimal duration of deferral remains unclear. We conducted a systematic review and individual participant data network meta-analysis with the aim of comparing the effectiveness of umbilical cord clamping strategies with different timings of clamping or with cord milking for preterm infants. METHODS: We searched medical databases and trial registries from inception until Feb 24, 2022 (updated June 6, 2023) for randomised controlled trials comparing cord clamping strategies for preterm infants...
November 14, 2023: Lancet
https://read.qxmd.com/read/37977169/deferred-cord-clamping-cord-milking-and-immediate-cord-clamping-at-preterm-birth-a-systematic-review-and-individual-participant-data-meta-analysis
#22
JOURNAL ARTICLE
Anna Lene Seidler, Mason Aberoumand, Kylie E Hunter, Angie Barba, Sol Libesman, Jonathan G Williams, Nipun Shrestha, Jannik Aagerup, James X Sotiropoulos, Alan A Montgomery, Gillian M L Gyte, Lelia Duley, Lisa M Askie
BACKGROUND: Umbilical cord clamping strategies at preterm birth have the potential to affect important health outcomes. The aim of this study was to compare the effectiveness of deferred cord clamping, umbilical cord milking, and immediate cord clamping in reducing neonatal mortality and morbidity at preterm birth. METHODS: We conducted a systematic review and individual participant data meta-analysis. We searched medical databases and trial registries (from database inception until Feb 24, 2022; updated June 6, 2023) for randomised controlled trials comparing deferred (also known as delayed) cord clamping, cord milking, and immediate cord clamping for preterm births (<37 weeks' gestation)...
December 9, 2023: Lancet
https://read.qxmd.com/read/37970724/2023-american-heart-association-and-american-academy-of-pediatrics-focused-update-on-neonatal-resuscitation-an-update-to-the-american-heart-association-guidelines-for-cardiopulmonary-resuscitation-and-emergency-cardiovascular-care
#23
REVIEW
Nicole K Yamada, Edgardo Szyld, Marya L Strand, Emer Finan, Jessica L Illuzzi, Beena D Kamath-Rayne, Vishal S Kapadia, Susan Niermeyer, Georg M Schmölzer, Amanda Williams, Gary M Weiner, Myra H Wyckoff, Henry C Lee
This 2023 focused update to the neonatal resuscitation guidelines is based on 4 systematic reviews recently completed under the direction of the International Liaison Committee on Resuscitation Neonatal Life Support Task Force. Systematic reviewers and content experts from this task force performed comprehensive reviews of the scientific literature on umbilical cord management in preterm, late preterm, and term newborn infants, and the optimal devices and interfaces used for administering positive-pressure ventilation during resuscitation of newborn infants...
November 16, 2023: Circulation
https://read.qxmd.com/read/37967898/delaying-umbilical-cord-clamping-for-two-minutes-cuts-deaths-in-premature-babies-studies-show
#24
JOURNAL ARTICLE
Jacqui Wise
No abstract text is available yet for this article.
November 15, 2023: BMJ: British Medical Journal
https://read.qxmd.com/read/37941523/umbilical-cord-milking-versus-delayed-cord-clamping-in-infants-28-to-32-weeks-a-randomized-trial
#25
RANDOMIZED CONTROLLED TRIAL
Anup Katheria, Jeff Szychowski, Waldemar A Carlo, Akila Subramaniam, Frank Reister, Jochen Essers, Farha Vora, Courtney Martin, Georg M Schmölzer, Brenda Law, Eugene Dempsey, Keelin O'Donoghue, Joseph Kaempf, Mark Tomlinson, Kevin Fulford, Bergen Folsom, Simon Karam, Rachael Morris, Toby Yanowitz, Stacy Beck, Erin Clark, Tara DuPont, Manoj Biniwale, Rangasamy Ramanathan, Shazia Bhat, Matthew Hoffman, Nitin Chouthai, Fayez Bany-Mohammed, Janardhan Mydam, Vivek Narendran, Fiona Wertheimer, Yvonne Gollin, Yvonne Vaucher, Kathy Arnell, Michael Varner, Gary Cutter, Nicole Wilson, Wade Rich, Neil Finer
OBJECTIVES: To determine whether rate of severe intraventricular hemorrhage (IVH) or death among preterm infants receiving placental transfusion with UCM is noninferior to delayed cord clamping (DCC). METHODS: Noninferiority randomized controlled trial comparing UCM versus DCC in preterm infants born 28 to 32 weeks recruited between June 2017 through September 2022 from 19 university and private medical centers in 4 countries. The primary outcome was Grade III/IV IVH or death evaluated at a 1% noninferiority margin...
December 1, 2023: Pediatrics
https://read.qxmd.com/read/37921769/extrauterine-placental-perfusion-and-oxygenation-in-infants-with-very-low-birth-weight-a-randomized-clinical-trial
#26
JOURNAL ARTICLE
Benjamin Kuehne, Berthold Grüttner, Martin Hellmich, Barbara Hero, Angela Kribs, André Oberthuer
IMPORTANCE: An extrauterine placental perfusion (EPP) approach for physiological-based cord clamping (PBCC) may support infants with very low birth weight (VLBW) during transition without delaying measures of support. OBJECTIVE: To test whether EPP in resuscitation of infants with VLBW results in higher hematocrit levels, better oxygenation, or improved infant outcomes compared with delayed cord clamping (DCC). DESIGN, SETTING, AND PARTICIPANTS: This nonblinded, single-center randomized clinical trial was conducted at a tertiary care neonatal intensive care unit...
November 1, 2023: JAMA Network Open
https://read.qxmd.com/read/37917943/intravenous-calcium-to-decrease-blood-loss-during-intrapartum-cesarean-delivery-a-randomized-controlled-trial
#27
RANDOMIZED CONTROLLED TRIAL
Jessica R Ansari, Alla Yarmosh, Guillermina Michel, Deirdre Lyell, Haley Hedlin, David N Cornfield, Brendan Carvalho, Brian T Bateman
OBJECTIVE: To evaluate whether prophylactic administration of 1 g of intravenous calcium chloride after cord clamping reduces blood loss from uterine atony during intrapartum cesarean delivery. METHODS: This single-center, block-randomized, placebo-controlled, double-blind superiority trial compared the effects of 1 g intravenous calcium chloride with those of saline placebo control on blood loss at cesarean delivery. Parturients at 34 or more weeks of gestation requiring intrapartum cesarean delivery after oxytocin exposure in labor were enrolled...
January 1, 2024: Obstetrics and Gynecology
https://read.qxmd.com/read/37876521/respiratory-patterns-in-spontaneously-breathing-near-term-lambs-delivered-by-caesarean-section-under-spinal-anaesthesia
#28
JOURNAL ARTICLE
I M Davies, K J Crossley, E V McGillick, I Nitsos, K Rodgers, A Thiel, V A Zahra, A B Te Pas, S B Hooper
INTRODUCTION: The transition to newborn life has typically been studied in intubated and mechanically ventilated newborn lambs delivered via caesarean section (CS) under general anaesthesia. As a result, little is known of the spontaneous breathing patterns in lambs at birth, particularly those at risk of developing respiratory distress (RD). We have developed a method for delivering spontaneously breathing near-term lambs to characterise their breathing patterns in the immediate newborn period...
2023: Frontiers in Pediatrics
https://read.qxmd.com/read/37839504/umbilical-cord-clamping-in-the-early-phases-of-the-covid-19-era-a-systematic-review-and-meta-analysis-of-reported-practice-and-recommendations-in-guidelines
#29
JOURNAL ARTICLE
Johan Berg, Li Thies-Lagergren, Jenny Svedenkrans, Jeremiah Samkutty, Sara Marie Larsson, Judith S Mercer, Heike Rabe, Ola Andersson, Mehreen Zaigham
OBJECTIVES: In the beginning of the COVID-19 pandemic, delayed umbilical cord clamping (CC) at birth may have been commonly discouraged despite a lack of convincing evidence of mother-to-neonate SARS-CoV-2 transmission. We aimed to systematically review guidelines, reports of practice and to analyze associations between timing of cord clamping and mother-to-neonate SARS-CoV-2 transmission during the early phases of the pandemic. METHODS: Major databases were searched December 1, 2019 to July 20, 2021...
October 13, 2023: International Journal of Infectious Diseases: IJID
https://read.qxmd.com/read/37791162/outcomes-of-neonatal-resuscitation-with-and-without-an-intact-umbilical-cord-a-meta-analysis
#30
REVIEW
Santosh Avinash B, Suresh Babu Mendu, Paramesh Pandala, Rakesh Kotha, Venkata Narayana Yerraguntla
Around the world, very few babies require a more intensive resuscitative effort for stabilization. The optimal timing of an intact umbilical cord to help with resuscitation is controversial. Our objective in the review is to compare the outcomes of neonatal resuscitation with and without an intact umbilical cord. A search of six electronic database libraries was explored for data released between 2014 and 2023. A manual search of secondary references in relevant studies was also performed. Studies focused only on randomized controlled trials comparing the outcomes of neonatal resuscitation with and without an intact umbilical cord at any gestational age...
August 2023: Curēus
https://read.qxmd.com/read/37778675/effect-of-maternal-hyperoxygenation-on-neonatal-outcomes-among-women-in-labour-with-pathological-cardiotocography-an-open-label-randomized-controlled-trial
#31
JOURNAL ARTICLE
Sruthy P Sulaiman, Nivedita Jha, Adhisivam Bethou, Hanumanthappa Nandeeha, Ajay Kumar Jha
BACKGROUND: Hyperoxygenation has shown promise in improving suspicious fetal heart patterns in women in labor. However, the effect of hyperoxygenation on neonatal outcomes in women in labor with pathologic fetal heart rate tracing has not been studied. OBJECTIVE: This study aimed to evaluate the effect of fractional inspiration of oxygen of 80% compared with fractional inspiration of oxygen of 40% on neonatal outcomes in women with pathologic fetal heart rate tracing...
September 29, 2023: American Journal of Obstetrics and Gynecology
https://read.qxmd.com/read/37726014/supine-versus-prone-position-during-delayed-cord-clamping-in-infants-%C3%A2-36-weeks-a-randomized-trial
#32
JOURNAL ARTICLE
Brahim Bensouda, Romain Mandel, Abdelwaheb Mejri, Laurent Tordjman, Marie St-Hilaire, Nabeel Ali
OBJECTIVE:  There is no recommendation in the literature on optimal positioning of the newborn immediately at birth during delayed cord clamping. To evaluate if prone positioning on the mother's chest at birth during delayed cord clamping leads to a higher hematocrit at 30 hours of life compared to supine positioning. STUDY DESIGN:  A randomized unblinded trial comparing prone and supine position of the newborn before umbilical cord clamping...
September 19, 2023: American Journal of Perinatology
https://read.qxmd.com/read/37713021/low-dose-remifentanil-in-preterm-cesarean-section-with-general-anesthesia-a-randomized-controlled-trial
#33
JOURNAL ARTICLE
Clément Chollat, Fabien Tourrel, Estelle Houivet, Romain Gillet, Eric Verspyck, Maryline Lecointre, Stéphane Marret, Vincent Compère
BACKGROUND AND OBJECTIVE: The conventional technique of general anesthesia induction during a Cesarean section involves the use of opioids only after cord clamping. We hypothesized that the use of remifentanil before cord clamping might reduce the use of maternal supplemental anesthetic agents and improve the maternal hemodynamics status and neonatal adaptation of the preterm neonate. METHODS: A phase III, double-blind, randomized, placebo-controlled, hospital-based trial enrolled parturients undergoing a Cesarean section under general anesthesia before 37 weeks of gestation...
September 15, 2023: Paediatric Drugs
https://read.qxmd.com/read/37696147/timing-of-umbilical-cord-occlusion-delayed-vs-early-in-preterm-babies-a-randomized-controlled-trial-code-p-trial
#34
RANDOMIZED CONTROLLED TRIAL
A Gregoraci, M Carbonell, A Linde, M Goya, N Maiz, P Gabriel, Y Villena, S Bérgamo, D Beneitez, I Montserrat, M C Céspedes, M Vargas, F Castillo, E Carreras
INTRODUCTION: Our hypothesis was that delayed cord clamping (DCC) (not earlier than 30 s; at 30-60 s) in premature neonates (born between 26.0 and 32.6 weeks of gestation), as compared with the usual early cord clamping (ECC), significantly reduces the need for blood transfusions and incidence of intraventricular haemorrhage (IVH) without an increased rate of maternal postpartum haemorrhage. MATERIAL AND METHODS: A prospective, open-label, randomized, controlled trial was conducted at Vall d'Hebron Hospital from July 2014 to December 2018...
October 2023: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://read.qxmd.com/read/37656131/cardiovascular-responses-to-mild-perinatal-asphyxia-in-growth-restricted-preterm-lambs
#35
JOURNAL ARTICLE
Matthew Oyang, Beth R Piscopo, Valerie Zahra, Atul Malhotra, Amy E Sutherland, Arvind Sehgal, Stuart B Hooper, Suzanne L Miller, Graeme R Polglase, Beth J Allison
<u>Background</u>: Growth-restricted neonates have worse outcomes after perinatal asphyxia, with more severe metabolic acidosis than appropriately grown neonates. The unique cardiovascular physiology associated with fetal growth restriction (FGR) may hinder growth-restricted neonates' cardiovascular response to asphyxia. However, research on asphyxia in FGR is limited. We aimed to compare cardiovascular haemodynamics in preterm growth-restricted and control lambs during mild perinatal asphyxia. <u>Methods:</u> Single umbilical artery ligation induced FGR in one twin, while the other served as a control...
September 1, 2023: American Journal of Physiology. Heart and Circulatory Physiology
https://read.qxmd.com/read/37654868/dry-arthroscopic-cartilage-repair-of-the-knee-joint-using-umbilical-cord-mesenchymal-stem-cells-kelly-clamp-technique
#36
JOURNAL ARTICLE
Tae Jin Lee, Chan Dong Jeong, Tae Hoon Lee
Among various cartilage regeneration treatments, methods using mesenchymal stem cells, whose safety and effectiveness have been verified, are emerging. Mesenchymal stem cell can be implanted through open arthrotomy or arthroscopy. Although arthroscopic surgery has the advantage of earlier recovery and less scar formation compared to open arthrotomy, dry arthroscopy is not technically easy, which is necessary for successful implantation and prevention of washout. This Technical Note will introduce an easier and more effective method of dry arthroscopic mesenchymal stem cell implantation...
August 2023: Arthroscopy Techniques
https://read.qxmd.com/read/37439849/effects-of-umbilical-cord-milking-versus-delayed-cord-clamping-on-systemic-blood-flow-in-intrauterine-growth-restricted-neonates-a-randomized-controlled-trial
#37
JOURNAL ARTICLE
Chaitra Angadi, Poonam Singh, Yash Shrivastava, Mayank Priyadarshi, Suman Chaurasia, Jaya Chaturvedi, Sriparna Basu
UNLABELLED: Recommendations for umbilical cord management in intrauterine growth-restricted (IUGR) neonates are lacking. The present randomized controlled trial compared hemodynamic effects of umbilical cord milking (UCM) with delayed cord clamping (DCC) in IUGR neonates > 28 weeks of gestation, not requiring resuscitation. One hundred seventy IUGR neonates were randomly allocated to intact UCM (4 times squeezing of 20 cm intact cord; n = 85) or DCC (cord clamping after 60 s; n = 85) immediately after delivery...
July 13, 2023: European Journal of Pediatrics
https://read.qxmd.com/read/37436521/variation-in-delivery-room-management-of-preterm-infants-across-europe-a-survey-of-the-union-of-european-neonatal-and-perinatal-societies
#38
JOURNAL ARTICLE
Camilla Gizzi, Luigi Gagliardi, Daniele Trevisanuto, Stefano Ghirardello, Sandra Di Fabio, Artur Beke, Giuseppe Buonocore, Antonia Charitou, Manuela Cucerea, Marina V Degtyareva, Boris Filipović-Grčić, Nelly Georgieva Jekova, Esin Koç, Joana Saldanha, Manuel Sanchez Luna, Dalia Stoniene, Heili Varendi, Matteo Calafatti, Giulia Vertecchi, Fabio Mosca, Corrado Moretti
The aim of the present study, endorsed by the Union of European Neonatal and Perinatal Societies (UENPS) and the Italian Society of Neonatology (SIN), was to analyze the current delivery room (DR) stabilization practices in a large sample of European birth centers that care for preterm infants with gestational age (GA) < 33 weeks. Cross-sectional electronic survey was used in this study. A questionnaire focusing on the current DR practices for infants < 33 weeks' GA, divided in 6 neonatal resuscitation domains, was individually sent to the directors of European neonatal facilities, made available as a web-based link...
July 12, 2023: European Journal of Pediatrics
https://read.qxmd.com/read/37422415/to-guide-future-practice-perinatal-trials-should-be-much-larger-simpler-and-less-fragile-with-close-to-100-ascertainment-of-mortality-and-other-key-outcomes
#39
JOURNAL ARTICLE
William Odita Tarnow-Mordi, Kristy Robledo, Ian Marschner, Lene Seidler, John Simes
The Australian Placental Transfusion Study (APTS) randomised 1,634 fetuses to delayed (≥60 s) versus immediate (≤10 s) clamping of the umbilical cord. Systematic reviews with meta-analyses, including this and similar trials, show that delaying clamping in preterm infants reduces mortality and need for blood transfusions. Amongst 1,531 infants in APTS followed up at two years, aiming to delay clamping for 60 s or more reduced the relative risk of the primary composite outcome of death or disability by 17% (p = 0...
August 2023: Seminars in Perinatology
https://read.qxmd.com/read/37390833/maternal-anaemia-and-the-risk-of-postpartum-haemorrhage-a-cohort-analysis-of-data-from-the-woman-2-trial
#40
JOURNAL ARTICLE
(no author information available yet)
BACKGROUND: Worldwide, more than half a billion women of reproductive age are anaemic. Each year, about 70 000 women who give birth die from postpartum haemorrhage. Almost all deaths are in low-income or middle-income countries. We examined the association between anaemia and the risk of postpartum haemorrhage. METHODS: We did a prospective cohort analysis of data from the World Maternal Antifibrinolytic-2 (WOMAN-2) trial. This trial enrols women with moderate or severe anaemia giving birth vaginally in hospitals in Pakistan, Nigeria, Tanzania, and Zambia...
August 2023: Lancet Global Health
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