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Teruyo Kida, Josef Flammer, Hidehiro Oku, Katarzyna Konieczka, Seita Morishita, Taeko Horie, Tsunehiko Ikeda
Retinal vein occlusion (RVO) is a common vascular disease of the retina; however, the pathogenesis of RVO is still unclear. Branch RVO (BRVO) commonly occurs at the arteriovenous crossing and it was formerly believed that the diseased artery mechanically compresses the vein. However, it has been reported that the retinal vein runs deep beneath the artery at the arteriovenous crossing in eyes with an arterial overcrossing, and the venous lumen often appears to be preserved, even at the arteriovenous crossing, as shown by optical coherence tomography...
December 2018: Data in Brief
Bożena Bądzyńska, Iwona Baranowska, Olga Gawryś, Janusz Sadowski
KEY POINTS: The development of new effective methods to treat arterial hypertension is hindered by uncertainty regarding its causes. According to one widespread concept hypertension is caused by abnormal blood circulation in the kidney, specifically by reduction of blood flow through the kidney medulla. However. such causal relationship has never been rigorously verified. We checked if in rats with three different forms of experimental hypertension prolonged selective elevation of renal medullary blood flow using local infusion of vasodilator bradykinin would lower arterial pressure...
October 18, 2018: Journal of Physiology
Te-Jung Lu, Chee-Hong Chan, Pin Ling, Yung-Mei Chao, Bo-Ying Bao, Chun-Yen Chiang, Te-Hsiu Lee, Yui-Ping Weng, Wei-Chih Kan, Te-Ling Lu
Defective renal salt and water excretion, together with increased salt intake, frequently contributes to hypertension. Recent studies indicate that Ste20 family kinases, such as proline-alanine-rich Ste20-related kinase (SPAK) and oxidative stress-response protein 1 (OSR1), are regulators of cell volume, ion transport, and hypertension. The aim of this study was to investigate whether mammalian sterile 20-like protein kinase 3 (MST3), which is also a stress-regulated kinase, is involved in the development of hypertension...
October 16, 2018: International Urology and Nephrology
Ting Hway Wong, Yu Jie Wong, Zheng Yi Lau, Nivedita Nadkarni, Gek Hsiang Lim, Dennis Chuen Chai Seow, Marcus Eng Hock Ong, Kelvin Bryan Tan, Hai V Nguyen, Chek Hooi Wong
OBJECTIVES: Readmission after acute care is a significant contributor to health care costs, and has been proposed as a quality indicator. Our earlier studies showed that patients aged ≥55 years who are injured by falls from heights of ≤0.5 m were at increased risk for long-term mortality, compared to patients by high-velocity blunt trauma (higher fall heights, road injuries, and other blunt trauma). We hypothesized that these patients are also at higher risk of readmission, compared to patients injured by high-velocity mechanisms...
October 9, 2018: Journal of the American Medical Directors Association
Juan Pablo Alderuccio, Wei Zhao, Amrita Desai, Nicolas Gallastegui, Jeremy Ramdial, Erik Kimble, Macarena I de la Fuente, Joseph D Rosenblatt, Jennifer R Chapman, Francisco Vega, Isildinha M Reis, Izidore S Lossos
PURPOSE: Given the paucity of data on higher-grade transformation (HGT) to aggressive lymphoma in patients with marginal zone lymphoma (MZL), we report on a large cohort of patients, identify risk factors, and determine HGT impact on overall survival (OS). METHODS: We analyzed 453 patients with biopsy-proven MZL seen at our institution between 1995 and 2016. Kaplan-Meier, Cox proportional hazards regression, and competing risk methods were used in analyses of time-to-event outcomes...
October 12, 2018: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
Biljana Jakovljevic, Tamara Nikolic Turnic, Nevena Jeremic, Jovana Jeremic, Jovana Bradic, Marko Ravic, Vladimir Lj Jakovljevic, Djordje Jelic, Dragan Radovanovic, Olga Pechanova, Vladimir Zivkovic
This study was aimed to assess the impact of aerobic and anaerobic type of exercise on blood pressure and redox status in normotensive and hypertensive rats. After 1 week of preconditioning feeding and 1 week of preconditioning running regimen, Wistar albino rats (n = 72; bw: 270 ± 50 g) were randomly assigned to three groups according to running protocol (high-intensity interval training (HIIT) or moderate-intensity training (MIT)): sedentary control, MIT, HIIT; spontaneous hypertensive sedentary control (SHR), SHR + MIT and SHR + HIIT...
October 11, 2018: Molecular and Cellular Biochemistry
Sabrina Bajwah, Joanna M Davies, Hanan Tanash, David C Currow, Adejoke O Oluyase, Magnus Ekström
Safety concerns are a barrier to prescribing benzodiazepines (BDZ) and opioids in Interstitial Lung Disease (ILD). We therefore examined association of BDZ and opioids on risk of admission to hospital and death.We conducted a population based longitudinal cohort study of fibrotic ILD patients starting Long Term Oxygen Therapy in Sweden 2005-2014. Effects of BDZ and opioids on rates of admission to hospital and mortality were analysed using Fine-Gray and Cox regression whilst adjusting for potential confounders...
October 11, 2018: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
Juan Kong, Li Han, Han Su, Yihan Hu, Xueshi Huang, Yan Lou
BACKGROUND/AIMS: Nephropathy related with renin can be alleviated with ACE-inhibitors or AT1R blockers, whereas they might be ineffective after long-term administration because of a feedback production of enhanced renin. Therefore, it is urgent to develop a new category of anti-nephropathy medicine directly targeting renin. Riligustilide (C20), originally isolated from the Chinese herb Ligusticumporteri, a rhizome, was confirmed effective against many diseases. METHODS: The therapeutic effect of C20 on renal injury and its underlying mechanism were investigated in three different nephrotic models, which were spontaneously hypertension rats (SHR) model, diabetic nephropathy in BTBR ob/ob mice model and 5/6-nephrectomized (5/6NX) rats model...
October 11, 2018: Cellular Physiology and Biochemistry
Cleide Adriane Signor Tirloni, Aniely Oliveira Silva, Rhanany Alan Calloi Palozi, Paulo César de Paula Vasconcelos, Roosevelt Isaias Carvalho Souza, Ariany Carvalho Dos Santos, Valter Paes de Almeida, Jane Manfron Budel, Lauro Mera de Souza, Arquimedes Gasparotto Junior
Talisia esculenta (A. St.-Hil.) Radlk. is a large tree belonging to family Sapindaceae and popularly known as "pitombeira" or "pitomba." Although species have relevant economic and medicinal uses in Brazil, no study has investigated its effectiveness as a diuretic, hypotensive, and antihypertensive agent. The aim of this study was to present a detailed anatomical and histochemical study for T. esculenta and provide important safety and efficacy parameters. After morpho-anatomical and microchemical study, a purified aqueous extract (ethanol soluble fraction obtained from T...
October 10, 2018: Journal of Medicinal Food
J Santabárbara, R Lopez-Anton, C de la Cámara, E Lobo, P Gracia-García, B Villagrasa, J Bueno-Notivol, G Marcos, A Lobo
OBJECTIVE: To evaluate whether clinically significant anxiety is an independent risk factor for dementia, taking into account both depression among potentially confounding factors and the competing risk of death. METHOD: During the Zaragoza Dementia and Depression (ZARADEMP) study, a random sample of community dwellers aged 55 years or older was assessed (n = 4803), and a two-wave, 4.5-year follow-up was completed. Geriatric Mental State (GMS)-AGECAT criteria were used to diagnose anxiety and DSM-IV criteria were applied to diagnose incident dementia...
October 10, 2018: Acta Psychiatrica Scandinavica
Ramsay Macdonald, Duilio Cascio, Michael J Collazo, Martin L Phillips, Robert T Clubb
In order to proliferate and mount an infection, many bacterial pathogens need to acquire iron from their host. The most abundant iron source in the body is the oxygen transporter hemoglobin (Hb). Streptococcus pyogenes, a potentially lethal human pathogen, uses the Shr protein to capture Hb on the cell surface. Shr is an important virulence factor, yet the mechanism by which it captures Hb and acquires its heme is not well understood. Here we show using NMR and biochemical methods that Shr binds Hb using two related modules that were previously defined as domains of unknown function (DUF1533)...
October 9, 2018: Journal of Biological Chemistry
Changyong Yang, Xiaoping Zhao, Xing Sun, Jinlong Li, Weiqiang Wang, Lianshan Zhang, Shaohua Gou
1. The in vivo pharmacokinetics (PK) profiles of a novel c-Met antibody-drug conjugate (ADC), SHR-A1403, were investigated and characterized in mice, rats and monkeys. 2. Serum concentrations of ADC and total antibody were detected using validated ELISA methods. The results showed low systemic clearance of both ADC and total antibody in all three species as reflected by gradual decrease in serum concentrations. Half-life (t1/2 ) of ADC ranged from 4.6 to 11.3 days in the three species. 3. Tissue distribution study in tumor-bearing mice showed high accumulation of 125 I-SHR-A1403 in tumor tissues over the other organs/tissues, indicating the favourable safety of SHR-A1403 and characteristics of an ADC drug...
October 9, 2018: Xenobiotica; the Fate of Foreign Compounds in Biological Systems
Ieva Kurilova, Regina G H Beets-Tan, Jessica Flynn, Mithat Gönen, Gary Ulaner, Elena N Petre, F Edward Boas, Etay Ziv, Hooman Yarmohammadi, Elisabeth G Klompenhouwer, Andrea Cercek, Nancy A Kemeny, Constantinos T Sofocleous
INTRODUCTION: The purpose of this study was to identify predictors of overall (OS) and liver progression-free survival (LPFS) following Yttrium-90 radioembolization (RAE) of heavily pretreated patients with colorectal cancer liver metastases (CLM), as well as to create and validate a predictive nomogram for OS. MATERIALS AND METHODS: Metabolic, anatomic, laboratory, pathologic, genetic, primary disease, and procedure-related factors, as well as pre- and post-RAE therapies in 103 patients with CLM treated with RAE from September 15, 2009 to March 21, 2017 were analyzed...
September 13, 2018: Clinical Colorectal Cancer
Ella Grilz, Florian Posch, Oliver Königsbrügge, Ilse Schwarzinger, Irene Marthe Lang, Christine Marosi, Ingrid Pabinger, Cihan Ay
Patients with cancer are at risk of developing venous and arterial thromboembolism (VTE and ATE). Elevated platelet-to-lymphocyte (PLR) and neutrophil-to-lymphocyte ratios (NLR) have been suggested as potential biomarkers for cancer-associated chronic inflammation, VTE and mortality. We investigated the association between PLR and NLR with VTE, ATE and mortality in patients with cancer. Within a prospective cohort study, we followed-up patients with newly diagnosed or progressing cancer for objectively confirmed, symptomatic VTE, ATE and death...
October 8, 2018: Thrombosis and Haemostasis
Hélène Roul, Murielle Mary-Krause, Jade Ghosn, Constance Delaugerre, Gilles Pialoux, Lise Cuzin, Odile Launay, Jean-Marc Lacombe, Amélie Menard, Pierre De Truchis, Jean-François Delfraissy, Laurence Weiss, Dominique Costagliola
OBJECTIVE: To assess CD4 recovery after combined antiretroviral therapy (cART) initiation with sustained virologic control. DESIGN: Cohort study based on the French Hospital Database on HIV (FHDH-ANRS CO4). METHODS: We selected naïve HIV-1-infected individuals initiating cART between 2006 and 2014 with CD4 counts < 500/mm who achieved virologic control, defined as two consecutive viral loads < 50 copies/mL. We estimated the cumulative incidence of CD4 recovery ≥ 500 cells/mm and identified associated factors, considering "virologic failure", "loss to follow-up", and "death" as competing events...
October 4, 2018: AIDS
Tian Tian, Yan Zhang, Tianqi Wu, Lei Yang, Chunxiao Chen, Nan Li, Yue Li, Siliang Xu, Ziyi Fu, Xianwei Cui, Chenbo Ji, Xia Chi, Meiling Tong, Ronghua Chen, Qin Hong, Youfang Hu
Attention-deficit/hyperactivity disorder (ADHD) is characterized by attention  deficit, hyperactivity, impulsivity, and learning and memory impairment. Although the pathogenesis of learning and memory impairment is still unknown, some studies have suggested an association with hippocampus dysfunction. We aimed to explore the role of miRNAs in the learning and memory impairments observed in ADHD. Differentially expressed hippocampal micro-ribonucleic acids (miRNAs) in spontaneously hypertensive rats (SHRs) and Wistar-Kyoto rats (WKYs) were detected on an Illumina HiSeq...
September 30, 2018: Journal of Cellular Biochemistry
Maryam Ebadi, Connie W Wang, Jennifer C Lai, Srinivasan Dasarathy, Matthew R Kappus, Michael A Dunn, Elizabeth J Carey, Aldo J Montano-Loza
BACKGROUND: Sarcopenia, characterized by low muscle mass, associates with mortality in patients with cirrhosis. Skeletal muscle area in a single computed tomography image at the level of the third lumbar vertebrate (L3) is a valid representative of whole body muscle mass. Controversy remains regarding applicability of psoas muscle to identify patients at greater risk of mortality. We aimed to determine psoas muscle index (PMI) association with skeletal muscle index (SMI) and to evaluate the capacity of PMI to predict liver transplant waitlist mortality...
September 29, 2018: Journal of Cachexia, Sarcopenia and Muscle
Ludmila S Peres Diaz, Mariano Luis Schuman, Maia Aisicovich, Jorge Eduardo Toblli, Carlos José Pirola, María Silvina Landa, Silvia Inés García
Cardiac tyhrotropin-releasing hormone (TRH) is overexpressed in the hypertrophied left ventricle (LV) of spontaneously hypertensive rats (SHR) and its inhibition prevents both hypertrophy and fibrosis. In a normal heart, the TRH increase induces fibrosis and hypertrophy opening the question of whether TRH could be a common mediator of left ventricular hypertrophy (LVH). We used angiotensin II (AngII) as an inductor of LVH to evaluate if the blockade of LV-TRH prevents hypertrophy and fibrosis in mice. We challenged C57BL/6 adult male mice with an infusion of AngII (osmotic pumps; 2 mg/kg...
September 27, 2018: Journal of Molecular and Cellular Cardiology
Tomasz Huc, Adrian Drapala, Marta Gawrys, Marek Konop, Klaudia Bielinska, Ewelina Zaorska, Emilia Samborowska, Aleksandra Wyczalkowska-Tomasik, Leszek Pączek, Michal Dadlez, Marcin Ufnal
Several studies suggest negative effects of trimethylamine oxide (TMAO) on the circulatory system. However, a number of studies showed protective functions of TMAO, a piezolyte and osmolyte, in animals exposed to high hydrostatic and/or osmotic stress. We evaluated the effects of TMAO treatment on the development of hypertension and its complications in male, Spontaneously Hypertensive Rats maintained on water (SHR-WATER) and SHR drinking TMAO water solution from weaning (SHR-TMAO). Wistar-Kyoto rats (WKY) were used as normotensive controls to discriminate between age-dependent and hypertension-dependent changes...
September 28, 2018: American Journal of Physiology. Heart and Circulatory Physiology
Gabriel Mulinari Dos Santos, Fábio Roberto de Souza Batista, Franziska Kirchweger, Stefan Tangl, Reinhard Gruber, Roberta Okamoto
OBJECTIVE: Hypertension is associated with cardiovascular diseases but also with alterations in bone quality. Hypertension therefore might be a risk factor for osseointegration. Preclinical studies suggest that losartan, an angiotensin II receptor blocker widely used to treat hypertension, has a beneficial effect in graft consolidation. Here we determine the effect of hypertension and losartan on osseointegration. METHODS: We used spontaneously hypertensive rats (SHR) and normotensive Wistar albinus rats receiving losartan (30 mg/kg, p...
September 28, 2018: Clinical Oral Implants Research
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