Munazzah Tasleem, Ambreen Shoaib, Asma Al-Shammary, Abdelmuhsin Abdelgadir, Zeina Alsamar, Qazi Mohammad Sajid Jamal, Abdulwahed Alrehaily, Fevzi Bardcki, Abdel Moneim E Sulieman, Tarun Kumar Upadhyay, Irfan Ahmad Ansari, Dakun Lai, Riadh Badroui, Dharmendra Kumar Yadav, Mohd Saeed
Protein tyrosine phosphatase-1B (PTP-1B) is a well-known therapeutic target for diabetes and obesity as it suppresses insulin and leptin signaling. PTP-1B deletion or pharmacological suppression boosted glucose homeostasis and insulin signaling without altering hepatic fat storage. Inhibitors of PTP-1B may be useful in the treatment of type 2 diabetes, and shikonin, a naturally occurring naphthoquinone dye pigment, is reported to inhibit PTP-1B and possess antidiabetic properties. Since the cell contains a large number of phosphatases, PTP-1B inhibitors must be effective and selective...
July 31, 2022: Cellular and Molecular Biology