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https://www.readbyqxmd.com/read/28622781/-iron-requirements-during-the-first-6-months-of-life
#1
A Lapillonne, O Becquet
Because of the postnatal redistribution of the iron store, the term infant born after an uneventful pregnancy virtually needs no iron during its first 6 months of life. On the other hand, several factors, such as duration of gestation, gender, mother's iron status, alteration of the iron placental transfer, significantly influence the iron store at birth. Because of their reduced body store at birth and their higher demand during catch-up growth, low birth weight infants should receive an iron supplement, which should be started earlier and given at a higher dose in the more premature infants...
May 2017: Archives de Pédiatrie: Organe Officiel de la Sociéte Française de Pédiatrie
https://www.readbyqxmd.com/read/28622417/the-antimigraine-butterbur-ingredient-isopetasin-desensitises-peptidergic-nociceptors-via-the-transient-receptor-potential-ankyrin-1-channel
#2
Silvia Benemei, Francesco De Logu, Simone Li Puma, Ilaria Maddalena Marone, Elisabetta Coppi, Filippo Ugolini, Wolfgang Liedtke, Pollastro Federica, Giovanni Appendino, Pierangelo Geppetti, Serena Materazzi, Romina Nassini
BACKGROUND AND PURPOSE: The mechanism of the antimigraine action of butterbur [Petasites hybridus (L.) Gaertn.] is unknown. Here, we investigated the ability of isopetasin, a major butterbur constituent, to specifically target the transient receptor ankyrin 1 (TRPA1) channel and to affect functional responses relevant to migraine. EXPERIMENTAL APPROACH: Single cell calcium imaging and patch-clamp recordings in human and rodent TRPA1-expressing cells, neurogenic motor responses in isolated rat/mouse urinary bladder, release of calcitonin gene-related peptide (CGRP) from mouse spinal cord in vitro, and facial rubbing in mice and meningeal blood flow in rat were examined...
June 16, 2017: British Journal of Pharmacology
https://www.readbyqxmd.com/read/28606652/rocuronium-versus-suxamethonium-for-rapid-sequence-induction-of-general-anaesthesia-for-caesarean-section-influence-on-neonatal-outcomes
#3
M Kosinova, P Stourac, M Adamus, D Seidlova, T Pavlik, P Janku, I Krikava, Z Mrozek, M Prochazka, J Klucka, R Stoudek, I Bartikova, H Harazim, H Robotkova, K Hejduk, Z Hodicka, M Kirchnerova, J Francakova, L Obare Pyszkova, J Hlozkova, P Sevcik
BACKGROUND: In a previous study we compared rocuronium and suxamethonium for rapid-sequence induction of general anaesthesia for caesarean section and found no difference in maternal outcome. There was however, a significant difference in Apgar scores. As this was a secondary outcome, we extended the study to explore this finding on a larger sample. METHODS: We included 488 parturients of whom 240 were women from the original study. Women were randomly assigned to receive either rocuronium 1mg/kg (ROC n=245) or suxamethonium 1mg/kg (SUX n=243) after propofol 2mg/kg...
May 10, 2017: International Journal of Obstetric Anesthesia
https://www.readbyqxmd.com/read/28591905/management-of-the-third-stage-of-labor-how-delayed-umbilical-cord-clamping-can-affect-neonatal-outcome
#4
Mitchell J Kresch
No abstract text is available yet for this article.
June 7, 2017: American Journal of Perinatology
https://www.readbyqxmd.com/read/28589518/forty-years-of-sodium-channels-structure-function-pharmacology-and-epilepsy
#5
William A Catterall
Voltage-gated sodium channels initiate action potentials in brain neurons. In the 1970s, much was known about the function of sodium channels from measurements of ionic currents using the voltage clamp method, but there was no information about the sodium channel molecules themselves. As a postdoctoral fellow and staff scientist at the National Institutes of Health, I developed neurotoxins as molecular probes of sodium channels in cultured neuroblastoma cells. During those years, Bruce Ransom and I crossed paths as members of the laboratories of Marshall Nirenberg and Philip Nelson and shared insights about sodium channels in neuroblastoma cells from my work and electrical excitability and synaptic transmission in cultured spinal cord neurons from Bruce's pioneering electrophysiological studies...
June 7, 2017: Neurochemical Research
https://www.readbyqxmd.com/read/28579948/modulation-of-low-voltage-activated-inward-current-permeable-to-sodium-and-calcium-by-darpp-32-drives-spontaneous-firing-of-insect-octopaminergic-neurosecretory-cells
#6
Bruno Lapied, Antoine Defaix, Maria Stankiewicz, Eléonore Moreau, Valérie Raymond
Identification of the different intracellular pathways that control phosphorylation/dephosphorylation process of ionic channels represents an exciting alternative approach for studying the ionic mechanisms underlying neuronal pacemaker activity. In the central nervous system of the cockroach Periplaneta americana, octopaminergic neurons, called dorsal unpaired median (DUM; DUM neurons), generate spontaneous repetitive action potentials. Short-term cultured adult DUM neurons isolated from the terminal abdominal ganglion (TAG) of the nerve cord were used to study the regulation of a tetrodotoxin-sensitive low-voltage-activated (LVA) channel permeable to sodium and calcium (Na/Ca), under whole cell voltage- and current-clamp conditions...
2017: Frontiers in Systems Neuroscience
https://www.readbyqxmd.com/read/28578361/current-umbilical-cord-clamping-practices-and-attitudes-of-obstetricians-and-midwives-toward-delayed-cord-clamping-in-saudi-arabia
#7
Nadia O Ibrahim, Hatouf H Sukkarieh, Rami T Bustami, Elaf A Alshammari, Lama Y Alasmari, Hanan M Al-Kadri
BACKGROUND: In Saudi Arabia, as in many countries, there is usually no clear definition of the timing of umbilical cord clamping (UCC) in the policies and procedures used by hospitals. The World Health Organization (WHO) recommends delayed cord clamping (DCC) ( > 1 minute after birth) as it can significantly improve hemodynamics and long-term neurodevelopment. OBJECTIVE: To investigate current practices of healthcare professionals on the timing of UCC in Saudi Arabia...
May 2017: Annals of Saudi Medicine
https://www.readbyqxmd.com/read/28576935/inflammatory-pain-reduces-c-fibre-activity-dependent-slowing-in-a-sex-dependent-manner-amplifying-nociceptive-input-to-the-spinal-cord
#8
Allen C Dickie, Barry McCormick, Veny Lukito, Kirsten L Wilson, Carole Torsney
C fibres display activity-dependent slowing (ADS), whereby repetitive stimulation (≥1Hz) results in a progressive slowing of action potential conduction velocity, which manifests as a progressive increase in response latency. However, the impact of ADS upon spinal pain processing has not been explored nor whether ADS is altered in inflammatory pain conditions. To investigate, compound action potentials were made, from dorsal roots isolated from rats with or without complete Freund's adjuvant (CFA) hindpaw inflammation, in response to electrical stimulus trains...
June 2, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28562299/delayed-umbilical-cord-clamping-after-birth
#9
(no author information available yet)
No abstract text is available yet for this article.
May 29, 2017: Pediatrics
https://www.readbyqxmd.com/read/28561189/delayed-umbilical-cord-clamping-at-32-weeks-gestation-implementation-and-outcomes
#10
Janine S Rhoades, Tatiana Bierut, Shayna N Conner, Methodius G Tuuli, Zachary A Vesoulis, George A Macones, Alison G Cahill
No abstract text is available yet for this article.
May 25, 2017: American Journal of Perinatology
https://www.readbyqxmd.com/read/28560313/urothelial-tight-junction-barrier-dysfunction-sensitizes-bladder-afferents
#11
Nicolas Montalbetti, Anna C Rued, Stefanie N Taiclet, Lori A Birder, F Aura Kullmann, Marcelo D Carattino
Interstitial cystitis/bladder pain syndrome (IC/BPS) is a chronic voiding disorder that presents with pain in the urinary bladder and surrounding pelvic region. A growing body of evidence suggests that an increase in the permeability of the urothelium, the epithelial barrier that lines the interior of the bladder, contributes to the symptoms of IC/BPS. To examine the consequence of increased urothelial permeability on pelvic pain and afferent excitability, we overexpressed in the urothelium claudin 2 (Cldn2), a tight junction (TJ)-associated protein whose message is significantly upregulated in biopsies of IC/BPS patients...
May 2017: ENeuro
https://www.readbyqxmd.com/read/28542001/acetaminophen-metabolite-n-acylphenolamine-induces-analgesia-via-transient-receptor-potential-vanilloid-1-receptors-expressed-on-the-primary-afferent-terminals-of-c-fibers-in-the-spinal-dorsal-horn
#12
Nobuko Ohashi, Daisuke Uta, Mika Sasaki, Masayuki Ohashi, Yoshinori Kamiya, Tatsuro Kohno
BACKGROUND: The widely used analgesic acetaminophen is metabolized to N-acylphenolamine, which induces analgesia by acting directly on transient receptor potential vanilloid 1 or cannabinoid 1 receptors in the brain. Although these receptors are also abundant in the spinal cord, no previous studies have reported analgesic effects of acetaminophen or N-acylphenolamine mediated by the spinal cord dorsal horn. We hypothesized that clinical doses of acetaminophen induce analgesia via these spinal mechanisms...
May 25, 2017: Anesthesiology
https://www.readbyqxmd.com/read/28538235/what-should-we-do-about-low-blood-pressure-in-preterm-infants
#13
Eugene M Dempsey
The management of preterm infants with low blood pressure soon after birth remains unresolved. The definition of what constitutes low blood pressure is uncertain. At birth, mean blood pressure appears to be gestation specific and increases in the first few days of life. Antenatal steroids, delayed cord clamping, and the avoidance of mechanical ventilation are all associated with higher mean blood pressure and less hypotension after birth. Rates of hypotension of 15-50% have been reported in various studies of extremely preterm infants...
2017: Neonatology
https://www.readbyqxmd.com/read/28526223/delayed-cord-clamping-in-newborns-born-at-term-at-risk-for-resuscitation-a-feasibility-randomized-clinical-trial
#14
Anup C Katheria, Melissa K Brown, Arij Faksh, Kasim O Hassen, Wade Rich, Danielle Lazarus, Jane Steen, Shahram Sean Daneshmand, Neil N Finer
Infants may benefit if resuscitation could be provided with an intact umbilical cord. Infants identified at risk for resuscitation were randomized to 1- or 5-minute cord clamping. The 5-minute group had greater cerebral oxygenation and blood pressure. Studies are needed to determine whether this translates into improved outcomes. TRIAL REGISTRATION: ClinicalTrials.gov: NCT02827409.
May 16, 2017: Journal of Pediatrics
https://www.readbyqxmd.com/read/28511482/effect-of-ketofol-on-pain-and-complication-after-caesarean-delivery-under-spinal-anaesthesia-a-randomized-double-blind-clinical-trial
#15
Molouk Jaafarpour, Aminolah Vasigh, Javaher Khajavikhan, Ali Khani
INTRODUCTION: Pain is the key concern of women after caesarean delivery that may interfere with breastfeeding. AIM: The aim of this study was to assess effect of ketofol (ketamine/propofol combination) on pain and complication after caesarean delivery under spinal anaesthesia. MATERIALS AND METHODS: In this randomized double-blind clinical trial, 92 parturient scheduled for elective caesarean delivery under spinal anaesthesia were included...
March 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28498927/efficacy-and-safety-of-carbetocin-given-as-an-intravenous-bolus-compared-with-short-infusion-for-caesarean-section-double-blind-double-dummy-randomized-controlled-non-inferiority-trial
#16
S Dell-Kuster, I Hoesli, O Lapaire, E Seeberger, L A Steiner, H C Bucher, T Girard
Background: Carbetocin is a synthetic oxytocin-analogue, which should be administered as bolus according to manufacturer's recommendations. A higher speed of oxytocin administration leads to increased cardiovascular side-effects. It is unclear whether carbetocin administration as short infusion has the same efficacy on uterine tone compared with bolus administration and whether haemodynamic parameters differ. Methods: In this randomized, double-blind, non-inferiority trial, women undergoing planned or unplanned Caesarean section (CS) under regional anaesthesia received a bolus and a short infusion, only one of which contained carbetocin 100 mcg (double dummy)...
May 1, 2017: British Journal of Anaesthesia
https://www.readbyqxmd.com/read/28489932/camkii%C3%AE-may-modulate-fentanyl-induced-hyperalgesia-via-a-celc-pag-rvm-spinal-cord-descending-facilitative-pain-pathway-in-rats
#17
Zhen Li, Pingping Yin, Jian Chen, Shenglan Jin, Jieqiong Liu, Fang Luo
Each of the lateral capsular division of central nucleus of amygdala(CeLC), periaqueductal gray (PAG), rostral ventromedial medulla(RVM) and spinal cord has been proved to contribute to the development of opioid-induced hyperalgesia(OIH). Especially, Ca2+/calmodulin-dependent protein kinase IIα (CaMKIIα) in CeLC and spinal cord seems to play a key role in OIH modulation. However, the pain pathway through which CaMKIIα modulates OIH is not clear. The pathway from CeLC to spinal cord for this modulation was explored in the present study...
2017: PloS One
https://www.readbyqxmd.com/read/28460036/reoperative-repair-of-descending-thoracic-and-thoracoabdominal-aneurysms%C3%A2
#18
Christopher Lau, Mario Gaudino, Ivancarmine Gambardella, Erin Mills, Monica Munjal, Mohamed Elsayed, Leonard Girardi
OBJECTIVES: To evaluate the results of reoperation on descending thoracic and thoracoabdominal aneurysms. METHODS: Sixty-nine consecutive patients undergoing reoperative aneurysm repair (20 descending thoracic and 49 thoracoabdominal) were compared to 602 contemporary primary repairs. Propensity matching was used to reduce observable differences in preoperative characteristics. RESULTS: The reoperation group was younger (60.2 vs 65.3 years, P  = 0...
April 27, 2017: European Journal of Cardio-thoracic Surgery
https://www.readbyqxmd.com/read/28446203/clinicians-views-and-experiences-of-offering-two-alternative-consent-pathways-for-participation-in-a-preterm-intrapartum-trial-a-qualitative-study
#19
Celine Y Chhoa, Alexandra Sawyer, Susan Ayers, Angela Pushpa-Rajah, Lelia Duley
BACKGROUND: The Cord Pilot Trial compared alternative policies for timing of cord clamping at very preterm birth at eight UK hospitals. Preterm birth can be rapid and unexpected, allowing little time for the usual consent process. Therefore, in addition to the usual procedure for written consent, a two-stage pathway for consent for use when birth was imminent was developed. The aims of this study were to explore clinicians' views and experiences of offering two consent pathways for recruitment to a randomised trial of timing of cord clamping at very preterm birth...
April 26, 2017: Trials
https://www.readbyqxmd.com/read/28443558/towards-evidence-based-resuscitation-of-the-newborn-infant
#20
REVIEW
Brett J Manley, Louise S Owen, Stuart B Hooper, Susan E Jacobs, Jeanie L Y Cheong, Lex W Doyle, Peter G Davis
Effective resuscitation of the newborn infant has the potential to save many lives around the world and reduce disabilities in children who survive peripartum asphyxia. In this Series paper, we highlight some of the important advances in the understanding of how best to resuscitate newborn infants, which includes monitoring techniques to guide resuscitative efforts, increasing awareness of the adverse effects of hyperoxia, delayed umbilical cord clamping, the avoidance of routine endotracheal intubation for extremely preterm infants, and therapeutic hypothermia for hypoxic-ischaemic encephalopathy...
April 22, 2017: Lancet
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