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https://www.readbyqxmd.com/read/30096039/endothelin-1-differentially-directs-lineage-specification-of-adipose-and-bone-marrow-derived-mesenchymal-stem-cells
#1
Ming-Song Lee, Jesse Wang, Huihua Yuan, Hongli Jiao, Tsung-Lin Tsai, Matthew W Squire, Wan-Ju Li
Blood vessels composed of endothelial cells (ECs) contact with mesenchymal stem cells (MSCs) in different tissues, suggesting possible interaction between these 2 types of cells. We hypothesized that endothelin-1 (ET1), a secreted paracrine factor of ECs, can differentially direct the lineages of adipose-derived stem cells (ASCs) and bone marrow-derived MSCs (BMSCs). Predifferentiated ASCs and BMSCs were treated with ET1 for 2 cell passages and then induced for multilineage differentiation. Our results showed that adipogenesis of ET1-pretreated ASCs and osteogenesis of ET1-pretreated BMSCs were increased compared to those of control cells...
August 10, 2018: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/30089767/mesenchymal-stem-stromal-cell-based-therapy-for-heart-failure-what-is-the-best-source
#2
Kazuya Kobayashi, Ken Suzuki
Transplantation of stem/progenitor cells is a promising, emerging treatment for heart failure (HF) in the modern era. Mesenchymal stem/stromal cells (MSCs) are considered as one of the most promising cell sources for this purpose, because of their powerful secretion of reparative factors and immunomodulatory ability. To date, various sources of MSCs have been examined for the treatment of HF in preclinical or clinical studies, including adult tissues (bone marrow and adipose tissue), perinatal tissues (umbilical cord and amnion), and pluripotent stem cells (induced pluripotent stem cells and embryonic stem cells)...
August 9, 2018: Circulation Journal: Official Journal of the Japanese Circulation Society
https://www.readbyqxmd.com/read/30087676/characteristics-and-immunomodulating-functions-of-adipose-derived-and-bone-marrow-derived-mesenchymal-stem-cells-across-defined-human-leukocyte-antigen-barriers
#3
Matthias Waldner, Wensheng Zhang, Isaac B James, Kassandra Allbright, Emmanuelle Havis, Jacqueline M Bliley, Aurora Almadori, Riccardo Schweizer, Jan A Plock, Kia M Washington, Vijay S Gorantla, Mario G Solari, Kacey G Marra, J Peter Rubin
Background: Vascularized composite allotransplantation opens new possibilities in reconstructive transplantation such as hand or face transplants. Lifelong immunosuppression and its side-effects are the main drawbacks of this procedure. Mesenchymal stem cells (MSCs) have clinically useful immunomodulatory effects and may be able to reduce the burden of chronic immunosuppression. Herein, we assess and compare characteristics and immunomodulatory capacities of bone marrow- and adipose tissue-derived MSCs isolated from the same human individual across defined human leukocyte antigen (HLA) barriers...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/30079130/stem-cell-therapy-for-faecal-incontinence-current-state-and-future-perspectives
#4
REVIEW
Jacobo Trébol, Ana Carabias-Orgaz, Mariano García-Arranz, Damián García-Olmo
Faecal continence is a complex function involving different organs and systems. Faecal incontinence is a common disorder with different pathogeneses, disabling consequences and high repercussions for quality of life. Current management modalities are not ideal, and the development of new treatments is needed. Since 2008, stem cell therapies have been validated, 36 publications have appeared (29 in preclinical models and seven in clinical settings), and six registered clinical trials are currently ongoing. Some publications have combined stem cells with bioengineering technologies...
July 26, 2018: World Journal of Stem Cells
https://www.readbyqxmd.com/read/30078595/equine-mesenchymal-stromal-cells-from-different-tissue-sources-display-comparable-immune-related-gene-expression-profiles-in-response-to-interferon-gamma-ifn-%C3%AE
#5
Jennifer M Cassano, Lisa A Fortier, Rebecca B Hicks, Rebecca M Harman, Gerlinde R Van de Walle
Mesenchymal stromal cells (MSC) have the therapeutic potential to decrease inflammation due to their immunomodulatory properties. They can be isolated from various tissue sources such as bone marrow, adipose tissue, and blood, but it is unknown how the tissue source of origin affects the responses of MSC to inflammatory stimuli. Here, we conceptually addressed this question by evaluating the immune-related gene expression profiles of equine MSC from different tissue sources in response to interferon gamma (IFN-γ) stimulation, with the goal to determine if there is a preferable MSC source for clinical application in an inflammatory environment...
August 2018: Veterinary Immunology and Immunopathology
https://www.readbyqxmd.com/read/30077816/exploiting-the-impact-of-the-secretome-of-mscs-isolated-from-different-tissue-sources-on-neuronal-differentiation-and-axonal-growth
#6
Rita C Assunção-Silva, B Mendes-Pinheiro, P Patrício, L Behie, F G Teixeira, L Pinto, A J Salgado
Cell transplantation free-based therapies using Mesenchymal stem cell (MSC) secretome have recently been presented as a possible for CNS related disorders. MSC secretome is rich in several bio-factors that act synergically towards the repair of damaged tissues, thus making it an ideal candidate for regenerative applications. Great effort is currently being made to map the molecules that compose the MSC secretome. Previous proteomic characterization of the secretome (in the form of conditioned media - CM) of MSCs derived from adipose tissue (ASC), bone-marrow (BMSC) and umbilical cord (HUCPVC) was performed by our group, where proteins relevant for neuroprotection, neurogenic, neurodifferentiation, axon guidance and growth functions were identified...
August 2, 2018: Biochimie
https://www.readbyqxmd.com/read/30075054/chronic-kidney-disease-is-associated-with-greater-bone-marrow-adiposity
#7
Gina N Woods, Susan K Ewing, Sigurdur Sigurdsson, Deborah M Kado, Joachim H Ix, Trisha F Hue, Gudny Eiriksdottir, Kaipin Xu, Vilmundur Gudnason, Thomas J Lang, Eric Vittinghoff, Tamara B Harris, Clifford J Rosen, Xiaojuan Li, Ann V Schwartz
Bone marrow adiposity is associated with aging, osteoporosis and reduced hematopoiesis as well as anorexia nervosa but little is known about the underlying mechanisms that affect marrow adiposity. Chronic kidney disease (CKD) may influence bone marrow adipose tissue (BMAT), possibly through loss of lean mass or higher circulating levels of sclerostin. To test these hypotheses, we investigated the cross-sectional association between estimated glomerular filtration rate (eGFR) as a measure of kidney function and 1 H-MRS based measurement of vertebral BMAT (L1-L4) in 475 older adults from the AGES-Reykjavik study...
August 3, 2018: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/30054522/endoscopic-transplantation-of-mesenchymal-stem-cell-sheets-in-experimental-colitis-in-rats
#8
Sehyung Pak, Sung Wook Hwang, In Kyong Shim, Sang Mun Bae, Yeon- Mi Ryu, Han-Byul Kim, Eun-Ju Do, Hye-Nam Son, Eun-Ji Choi, Sun-Ha Park, Sang-Yeob Kim, Sang Hyoung Park, Byong Duk Ye, Suk-Kyun Yang, Nobuo Kanai, Masanori Maeda, Teruo Okano, Dong-Hoon Yang, Jeong-Sik Byeon, Seung-Jae Myung
Owing to the recent progress in regenerative medicine technology, clinical trials that harnessed the regeneration and immune modulation potentiality of stem cells for treating IBD have shown promising results. We investigated the feasibility and utility of intraluminal endoscopic transplantation of rat MSC sheets in murine models of experimental colitis for targeted delivery of stem cells to lesions. We isolated adipose-derived mesenchymal stem cells (AD-MSC) and bone marrow-derived mesenchymal stem cells (BM-MSC) from EGFP-transgenic rats and fabricated the cells in sheet forms using temperature-responsive culture dishes...
July 27, 2018: Scientific Reports
https://www.readbyqxmd.com/read/30053444/the-suppression-effect-of-dendritic-cells-maturation-by-adipose-derived-stem-cells-through-tgf-%C3%AE-1-related-pathway
#9
Yu-Chi Wang, Rong-Fu Chen, Gerald Brandacher, W P Andrew Lee, Yur-Ren Kuo
BACKGROUND: Our previous studies demonstrated that adipose-derived stem cells (ASCs) could modulate regulatory T cells (Treg) and prolong hind-limb allotransplant survival in vitro and in vivo. Dendritic cells (DC) play a pivotal role in innate and adaptive immunity. The aim of this study is to investigate the underlying mechanism of ASCs in modulating DC maturation. MATERIALS AND METHODS: ASCs were isolated from rodent adipose tissue, DCs were derived from the bone marrow, and CD4+ T cells were purified from splenocytes...
July 24, 2018: Experimental Cell Research
https://www.readbyqxmd.com/read/30051318/therapeutic-potential-of-adipose-stem-cells
#10
Rachel A Sabol, Annie C Bowles, Alexandra Côté, Rachel Wise, Nicholas Pashos, Bruce A Bunnell
Adipose stem cells (ASCs) have gained attention in the fields of stem cells regenerative medicine due to their multifaceted therapeutic capabilities. Promising preclinical evidence of ASCs has supported the substantial interest in the use of these cells as therapy for human disease. ASCs are an adult stem cell resident in adipose tissue with the potential to differentiation along mesenchymal lineages. They also are known to be recruited to sites of inflammation where they exhibit strong immunomodulatory capabilities to promote wound healing and regeneration...
July 27, 2018: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/30044182/comparison-of-antibacterial-and-immunological-properties-of-mesenchymal-stem-stromal-cells-from-equine-bone-marrow-endometrium-and-adipose-tissue
#11
Yennifer Cortes, Karin Amilon, Elisabeth Rink, Georgina Black, Zofia Lisowski, Xavier Donadeu, Cristina L Esteves
Equine Mesenchymal stem/stromal cells (MSCs) are multipotent cells that are widely used for treatment of musculoskeletal injuries, and there is significant interest in expanding their application to non-orthopedic conditions. MSCs possess antibacterial and immunomodulatory properties which may be relevant for combatting infection, however, comparative studies using MSCs from different origins have not been carried out in the horse, and this was the focus of the present study. Our results showed that MSC-conditioned media attenuated the growth of Escherichia coli, and that this effect was, on average, more pronounced for endometrium (EM)- and adipose tissue (AT)- than for bone marrow (BM)-derived MSCs...
July 25, 2018: Stem Cells and Development
https://www.readbyqxmd.com/read/30041472/cartilage-regeneration-in-humans-with-adipose-tissue-derived-stem-cells-and-adipose-stromal-vascular-fraction-cells-updated-status
#12
REVIEW
Jaewoo Pak, Jung Hun Lee, Natalie Pak, Yoon Pak, Kwang Seung Park, Jeong Ho Jeon, Byeong Chul Jeong, Sang Hee Lee
Adipose tissue-derived stem cells (ASCs) in the form of stromal vascular fraction (SVF) and cultured expansion have been applied in clinical settings in some countries to treat osteoarthritis (OA) of knees, one of the most common debilitating, incurable disorders. Since the first report of successful cartilage-like tissue regeneration with autologous adipose SVF containing ASCs, there has been a gradual increase in the number of publications confirming such results. Thus far, most of the reports have been limited to treatments of OA of knees...
July 23, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/30038881/molecular-differences-between-subtypes-of-bone-marrow-adipocytes
#13
Clarissa S Craft, Ziru Li, Ormond A MacDougald, Erica L Scheller
Purpose of Review: Bone marrow adipocytes (BMAs) have distinct molecular properties and physiologic responses depending on their location within the skeleton. Recent Findings: This concept was introduced in the 1970s and validated more recently in the contexts of cold exposure, sympathetic tone, hematopoiesis, diabetes, lactation, fasting and caloric restriction. Summary: In this brief review, we discuss the concept of regulated vs constitutive BMAs, explore their evolutionary and microenvironmental origins, define the site-specific molecular features of BMAs, and discuss the translational implications of the dual bone marrow adipose tissue hypothesis...
March 2018: Current Molecular Biology Reports
https://www.readbyqxmd.com/read/30036727/bone-regeneration-strategies-engineered-scaffolds-bioactive-molecules-and-stem-cells-current-stage-and-future-perspectives
#14
REVIEW
Antalya Ho-Shui-Ling, Johanna Bolander, Laurence E Rustom, Amy Wagoner Johnson, Frank P Luyten, Catherine Picart
Bone fractures are the most common traumatic injuries in humans. The repair of bone fractures is a regenerative process that recapitulates many of the biological events of embryonic skeletal development. Most of the time it leads to successful healing and the recovery of the damaged bone. Unfortunately, about 5-10% of fractures will lead to delayed healing or non-union, more so in the case of co-morbidities such as diabetes. In this article, we review the different strategies to heal bone defects using synthetic bone graft substitutes, biologically active substances and stem cells...
October 2018: Biomaterials
https://www.readbyqxmd.com/read/30036679/differential-effects-of-high-fat-diet-and-exercise-training-on-bone-and-energy-metabolism
#15
Ann-Kristin Picke, Lykke Sylow, Lisbeth L V Møller, Rasmus Kjøbsted, Felix N Schmidt, Mikkel Wermer Steejn, Juliane Salbach-Hirsch, Christine Hofbauer, Matthias Blüher, Anja Saalbach, Björn Busse, Martina Rauner, Lorenz C Hofbauer
Bone microarchitecture and strength are impaired by obesity and physical inactivity, but the underlying molecular regulation of bone metabolism in response to these factors is not well understood. Therefore, we analyzed bone and energy metabolism in male mice fed a high-fat or standard chow diet for 12 weeks with or without free access to running wheels. High-fat diet (HFD) mimicked the human condition of obesity and insulin resistance, including symptoms such as elevated serum glucose and insulin levels and reduced insulin-stimulated glucose uptake into muscle and adipose tissue...
July 20, 2018: Bone
https://www.readbyqxmd.com/read/30036140/effect-of-platelet-rich-plasma-on-chondrogenic-differentiation-of-adipose-and-bone-marrow-derived-mesenchymal-stem-cells
#16
Jr-Jiun Liou, Benjamin B Rothrauff, Peter G Alexander, Rocky S Tuan
Post-traumatic and focal cartilage defects of the knee affect over 3 million Americans annually. Autologous cell-based cartilage repair, for example, autologous chondrocyte implantation, is limited by the need for ex vivo chondrocyte expansion and donor site morbidity. Mesenchymal stem cells (MSCs), owing to their relative ease of isolation, higher replication activity, and chondrogenic potential, represent an alternative reparative cell type. Platelet-rich plasma (PRP) is an autologous, growth factor-rich biologic preparation that has recently received increasing attention and use as a therapeutic adjunct for the treatment of degenerative joint diseases, and there is evidence suggesting that PRP acts by promoting stem cell proliferation and tissue healing...
July 23, 2018: Tissue Engineering. Part A
https://www.readbyqxmd.com/read/30017591/pgc-1%C3%AE-controls-skeletal-stem-cell-fate-and-bone-fat-balance-in-osteoporosis-and-skeletal-aging-by-inducing-taz
#17
Bo Yu, Lihong Huo, Yunsong Liu, Peng Deng, John Szymanski, Jiong Li, Xianghang Luo, Christine Hong, Jiandie Lin, Cun-Yu Wang
Aberrant lineage specification of skeletal stem cells (SSCs) contributes to reduced bone mass and increased marrow adipose tissue (MAT) in osteoporosis and skeletal aging. Although master regulators of osteoblastic and adipogenic lineages have been identified, little is known about factors that are associated with MAT accumulation and osteoporotic bone loss. Here, we identify peroxisome-proliferator-activated receptor γ coactivator 1-α (PGC-1α) as a critical switch of cell fate decisions whose expression decreases with aging in human and mouse SSCs...
August 2, 2018: Cell Stem Cell
https://www.readbyqxmd.com/read/30010050/bone-marrow-derived-and-adipose-derived-mesenchymal-stem-cell-therapy-in-primary-knee-osteoarthritis-a-narrative-review
#18
REVIEW
Prathap Jayaram, Uzoh Ikepeama, Joshua B Rothenberg, Gerard A Malanga
Regenerative medicine in the context of musculoskeletal injury is a broad term that offers potential therapeutic solutions to restore or repair damaged tissue. The current focus in recent literature and clinical practice has been on cell based therapy. In particular, much attention has been centered on autologous bone marrow concentrate (BMAC) and adipose derived (AD) mesenchymal stem cells (MSCs) for cartilage and tendon disorders. This article provides an overview of MSC derived therapy and offers a comprehensive review of Adipose and Bone Marrow derived MSC therapy in primary knee osteoarthritis OA...
July 13, 2018: PM & R: the Journal of Injury, Function, and Rehabilitation
https://www.readbyqxmd.com/read/30009463/exosomes-derived-from-mesenchymal-stem-cells-exert-therapeutic-effect-in-a-rat-model-of-cavernous-nerves-injury
#19
M Li, H Lei, Y Xu, H Li, B Yang, C Yu, Y Yuan, D Fang, Z Xin, R Guan
Postradical prostatectomy erectile dysfunction (pRP-ED) is a major health issue. There has been a shortage of an effective treatment method until now. In this study, a total of 48 adult male Sprague-Dawley (SD) rats were randomly equally divided into four groups, including group 1-sham surgery with cavernous nerve exposure plus vehicle, group 2-bilateral cavernous nerve injury (BCNI) plus vehicle, group 3-BCNI plus adipose-derived mesenchymal stem cells (ADSCs)-derived exosomes (ADSC-Exo), and group 4-BCNI plus bone marrow-derived mesenchymal stem cell (BMSCs)-derived exosomes (BMSC-Exo)...
July 16, 2018: Andrology
https://www.readbyqxmd.com/read/30006022/chemical-shift-encoded-mri-for-assessment-of-bone-marrow-adipose-tissue-fat-composition-pilot-study-in-premenopausal-versus-postmenopausal-women
#20
Dimitri Martel, Benjamin Leporq, Mary Bruno, Ravinder R Regatte, Stephen Honig, Gregory Chang
OBJECT: To quantify and compare subregional proximal femur bone marrow fat composition in premenopausal and postmenopausal women using chemical shift-encoded-MRI (CSE-MRI). MATERIALS AND METHODS: A multi gradient-echo sequence at 3 T was used to scan both hips of premenopausal (n = 9) and postmenopausal (n = 18) women. Subregional fat composition (saturation, poly-unsaturation, mono-unsaturation) was quantitatively assessed in the femoral head, femoral neck, Ward's triangle, greater trochanter, and proximal shaft in bone marrow adipose tissue and separately within red and yellow marrow adipose tissue...
July 10, 2018: Magnetic Resonance Imaging
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