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https://www.readbyqxmd.com/read/30527470/effects-of-ghrelin-on-the-oxidative-stress-and-healing-of-the-colonic-anastomosis-in-rats
#1
Humberto Fenner Lyra Junior, Leonardo de Lucca Schiavon, Igor Kunze Rodrigues, Daniella Serafin Couto Vieira, Roberta de Paula Martins, Bruna Lenfers Turnes, Alexandra Susana Latini, Armando José D'Acâmpora
BACKGROUND: Anastomotic leakage is the deadliest complication of colonic procedures. Ghrelin is an orexigenic hormone with potent actions on growth hormone release and functions in the processes of growth, tissue inflammation, repair, and oxidative stress. We evaluated the hypothesis that the exogenous administration of ghrelin causes beneficial effects on the healing of colonic anastomosis. MATERIALS AND METHODS: Sixty-four male Wistar rats were randomly assigned to eight subgroups receiving postoperative intraperitoneal administration of ghrelin (23 μg/kg/d) or saline after a colonic anastomosis...
February 2019: Journal of Surgical Research
https://www.readbyqxmd.com/read/30514967/efficacy-of-a-novel-single-dose-oral-antibiotic-for-urogenital-gonorrhoea
#2
Annette Fenner
No abstract text is available yet for this article.
December 4, 2018: Nature Reviews. Urology
https://www.readbyqxmd.com/read/30425343/ecoin-device-stops-patients-from-spending-a-penny
#3
Annette Fenner
No abstract text is available yet for this article.
November 13, 2018: Nature Reviews. Urology
https://www.readbyqxmd.com/read/30356147/ar-variants-in-ctcs-correlate-with-outcomes
#4
Annette Fenner
No abstract text is available yet for this article.
October 24, 2018: Nature Reviews. Urology
https://www.readbyqxmd.com/read/30356146/mirabegron-miracle-cure-for-male-incontinence
#5
Annette Fenner
No abstract text is available yet for this article.
October 24, 2018: Nature Reviews. Urology
https://www.readbyqxmd.com/read/30356145/mismatch-mutations-aggressive-but-sensitive
#6
Annette Fenner
No abstract text is available yet for this article.
October 24, 2018: Nature Reviews. Urology
https://www.readbyqxmd.com/read/30356144/microrna-signature-aids-diagnosis
#7
Annette Fenner
No abstract text is available yet for this article.
October 24, 2018: Nature Reviews. Urology
https://www.readbyqxmd.com/read/30326586/dietary-sodium-restriction-reduces-arterial-stiffness-vascular-tgf-%C3%AE-dependent-fibrosis-and-marinobufagenin-in-young-normotensive-rats
#8
Yulia N Grigorova, Wen Wei, Natalia Petrashevskaya, Valentina Zernetkina, Ondrej Juhasz, Rachel Fenner, Christian Gilbert, Edward G Lakatta, Joseph I Shapiro, Alexei Y Bagrov, Olga V Fedorova
High salt (HS) intake stimulates the production of marinobufagenin (MBG), an endogenous steroidal Na/K-ATPase ligand, which activates profibrotic signaling. HS is accompanied by a blood pressure (BP) increase in salt-sensitive hypertension, but not in normotensive animals. Here, we investigated whether HS stimulates MBG production and activates transforming growth factor-beta (TGF-β) profibrotic signaling in young normotensive rats, and whether these changes can be reversed by reducing salt to a normal salt (NS) level...
October 15, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/30325305/avurt-aspirin-versus-placebo-for-the-treatment-of-venous-leg-ulcers-a-phase-ii-pilot-randomised-controlled-trial
#9
Helen Tilbrook, Laura Clark, Liz Cook, Martin Bland, Hannah Buckley, Ian Chetter, Jo Dumville, Chris Fenner, Rachael Forsythe, Rhian Gabe, Keith Harding, Alison Layton, Ellie Lindsay, Catriona McDaid, Christine Moffatt, Debbie Rolfe, Illary Sbizzera, Gerard Stansby, David Torgerson, Peter Vowden, Laurie Williams, Robert Hinchliffe
BACKGROUND: Venous leg ulcers (VLUs) are the most common cause of leg ulceration, affecting 1 in 100 adults. VLUs may take many months to heal (25% fail to heal). Estimated prevalence is between 1% and 3% of the elderly population. Compression is the mainstay of treatment and few additional therapies exist to improve healing. Two previous trials have indicated that low-dose aspirin, as an adjunct to standard care, may improve healing time, but these trials were insufficiently robust. Aspirin is an inexpensive, widely used medication but its safety and efficacy in the treatment of VLUs remains to be established...
October 2018: Health Technology Assessment: HTA
https://www.readbyqxmd.com/read/30242908/screening-for-peripheral-artery-disease-in-people-with-diabetes-authors-reply
#10
B Vriens, F D'Abate, B A Ozdemir, C Fenner, W Maynard, J Budge, D Carradice, R J Hinchliffe
We thank Hersant and colleagues for their interest in our work [1]. Our study was principally designed to address the utility of clinical examination and adjunctive tests to exclude peripheral artery disease (PAD) in people with diabetes-related foot ulceration. We emphasize the importance of a negative likelihood ratio (and sensitivity) throughout because a missed diagnosis has potentially more severe consequences. This article is protected by copyright. All rights reserved.
September 22, 2018: Diabetic Medicine: a Journal of the British Diabetic Association
https://www.readbyqxmd.com/read/30232558/everolimus-in-patients-with-multiply-relapsed-or-cisplatin-refractory-germ-cell-tumors-results-of-a-phase-ii-single-arm-open-label-multicenter-trial-radit-of-the-german-testicular-cancer-study-group
#11
Martin Fenner, Christoph Oing, Annette Dieing, Thomas Gauler, Karin Oechsle, Anja Lorch, Marcus Hentrich, Hans-Georg Kopp, Carsten Bokemeyer, Friedemann Honecker
BACKGROUND: Treatment options for patients (pts) with multiply relapsed or refractory metastatic germ cell cancer (GCC) are limited. The mTOR inhibitor everolimus has been approved for the treatment of different solid tumors and was assessed in refractory GCC within this phase II RADIT trial of the German Testicular Cancer Study Group. METHODS: GCC pts progressing during cisplatin-based salvage chemotherapy, or relapsing after high-dose chemotherapy, or failing at least two lines of cisplatin-based chemotherapy were eligible...
September 19, 2018: Journal of Cancer Research and Clinical Oncology
https://www.readbyqxmd.com/read/30217278/oral-supplements-in-atopic-dermatitis
#12
Justine Fenner, Nanette B Silverberg
Atopic dermatitis (AD) is the most common chronic inflammatory skin disorder. The disease is typified by chronic pruritus, a series of signs and symptoms associated with immune dysfunction (eg, increased immunoglobulin E mediated allergies), and abnormal skin barrier dysfunction (eg, increased response to irritants). Due to the chronic itch and reactivity, patients and parents of affected children will seek therapy. Therapies range from emollients to topical medicaments, including topical corticosteroids, and immunosuppressive agents...
September 2018: Clinics in Dermatology
https://www.readbyqxmd.com/read/30217275/skin-diseases-associated-with-atopic-dermatitis
#13
Justine Fenner, Nanette B Silverberg
Atopic dermatitis is a common chronic pruritic inflammatory skin disorder, characterized by an abnormal skin barrier, immune dysfunction, and an altered skin microbiome. Atopic dermatitis may be seen in conjunction with a variety of other skin disorders due to the complex pathogenesis of atopic dermatitis, involving genetic and environmental factors that are associated with immune dysfunction, barrier defects, and altered skin microbiomes. Skin disorders associated with atopic dermatitis include diseases sharing similar genetic origins like ichthyosis vulgaris, infectious diseases such as impetigo, and eczema herpeticum, in addition to the cutaneous autoimmune diseases, alopecia areata, and vitiligo...
September 2018: Clinics in Dermatology
https://www.readbyqxmd.com/read/30208701/trends-in-micropollutant-biotransformation-along-a-solids-retention-time-gradient
#14
Stefan Achermann, Per Falås, Adriano Joss, Cresten B Mansfeldt, Yujie Men, Bernadette Vogler, Kathrin Fenner
For many polar organic micropollutants, biotransformation by activated sludge microorganisms is a major removal process during wastewater treatment. However, our current understanding of how wastewater treatment operations influence microbial communities and their micropollutant biotransformation potential is limited, leaving major parts of observed variability in biotransformation rates across treatment facilities unexplained. Here, we present biotransformation rate constants for 42 micropollutants belonging to different chemical classes along a gradient of solids retention time (SRT)...
October 1, 2018: Environmental Science & Technology
https://www.readbyqxmd.com/read/30133839/time-dependent-antiarrhythmic-effects-of-flecainide-on-induced-atrial-fibrillation-in-horses
#15
Helena Carstensen, Eva Z Hesselkilde, Merle Fenner, Ameli V Loft-Andersen, Mette Flethøj, Jørgen K Kanters, Stefan M Sattler, Jacob Tfelt-Hansen, Steen Pehrson, Thomas Jespersen, Rikke Buhl
BACKGROUND: Pharmacological treatment of atrial fibrillation (AF) in horses can be challenging because of low efficacy and adverse effects. Flecainide has been tested with variable efficacy. OBJECTIVE: To test whether the efficacy of flecainide is dependent on AF duration. ANIMALS: Nine Standardbred mares. METHODS: Factorial study design. All horses were instrumented with a pacemaker and assigned to a control or an AF group...
September 2018: Journal of Veterinary Internal Medicine
https://www.readbyqxmd.com/read/30093626/bcg-enriches-t-reg-cells
#16
Annette Fenner
No abstract text is available yet for this article.
October 2018: Nature Reviews. Urology
https://www.readbyqxmd.com/read/30065358/unearthing-roles-for-the-gut-microbiome
#17
Annette Fenner
No abstract text is available yet for this article.
October 2018: Nature Reviews. Urology
https://www.readbyqxmd.com/read/30053130/inhibition-of-ccl3-abrogated-precursor-cell-fusion-and-bone-erosions-in-human-osteoclast-cultures-and-murine-collagen-induced-arthritis
#18
Lauren A Jordan, Malin C Erlandsson, Benjamin F Fenner, Ruth Davies, Ann K Harvey, Ernest H Choy, Rachel Errington, Maria I Bokarewa, Anwen S Williams
Objective: Macrophage inflammatory protein 1-alpha (CCL3) is a chemokine that regulates macrophage trafficking to the inflamed joint. The agonistic effect of CCL3 on osteolytic lesions in patients with multiple myeloma is recognized; however, its role in skeletal damage during inflammatory arthritis has not been established. The aim of the study was to explore the role of osteoclast-associated CCL3 upon bone resorption, and to test its pharmacological blockade for protecting against bone pathology during inflammatory arthritis...
November 1, 2018: Rheumatology
https://www.readbyqxmd.com/read/30038428/chlamydia-paralyses-neutrophils-via-cpaf
#19
Annette Fenner
No abstract text is available yet for this article.
September 2018: Nature Reviews. Urology
https://www.readbyqxmd.com/read/30037007/there-is-always-another-way-cytomegalovirus-multifaceted-dissemination-schemes
#20
REVIEW
Joseph W Jackson, Tim Sparer
Human cytomegalovirus (HCMV) is a β-herpes virus that is a significant pathogen within immune compromised populations. HCMV morbidity is induced through viral dissemination and inflammation. Typically, viral dissemination is thought to follow Fenner's hypothesis where virus replicates at the site of infection, followed by replication in the draining lymph nodes, and eventually replicating within blood filtering organs. Although CMVs somewhat follow Fenner's hypothesis, they deviate from it by spreading primarily through innate immune cells as opposed to cell-free virus...
July 20, 2018: Viruses
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