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B Vriens, F D'Abate, B A Ozdemir, C Fenner, W Maynard, J Budge, D Carradice, R J Hinchliffe
We thank Hersant and colleagues for their interest in our work [1]. Our study was principally designed to address the utility of clinical examination and adjunctive tests to exclude peripheral artery disease (PAD) in people with diabetes-related foot ulceration. We emphasize the importance of a negative likelihood ratio (and sensitivity) throughout because a missed diagnosis has potentially more severe consequences. This article is protected by copyright. All rights reserved.
September 22, 2018: Diabetic Medicine: a Journal of the British Diabetic Association
Martin Fenner, Christoph Oing, Annette Dieing, Thomas Gauler, Karin Oechsle, Anja Lorch, Marcus Hentrich, Hans-Georg Kopp, Carsten Bokemeyer, Friedemann Honecker
BACKGROUND: Treatment options for patients (pts) with multiply relapsed or refractory metastatic germ cell cancer (GCC) are limited. The mTOR inhibitor everolimus has been approved for the treatment of different solid tumors and was assessed in refractory GCC within this phase II RADIT trial of the German Testicular Cancer Study Group. METHODS: GCC pts progressing during cisplatin-based salvage chemotherapy, or relapsing after high-dose chemotherapy, or failing at least two lines of cisplatin-based chemotherapy were eligible...
September 19, 2018: Journal of Cancer Research and Clinical Oncology
Justine Fenner, Nanette B Silverberg
Atopic dermatitis (AD) is the most common chronic inflammatory skin disorder. The disease is typified by chronic pruritus, a series of signs and symptoms associated with immune dysfunction (eg, increased immunoglobulin E mediated allergies), and abnormal skin barrier dysfunction (eg, increased response to irritants). Due to the chronic itch and reactivity, patients and parents of affected children will seek therapy. Therapies range from emollients to topical medicaments, including topical corticosteroids, and immunosuppressive agents...
September 2018: Clinics in Dermatology
Justine Fenner, Nanette B Silverberg
Atopic dermatitis is a common chronic pruritic inflammatory skin disorder, characterized by an abnormal skin barrier, immune dysfunction, and an altered skin microbiome. Atopic dermatitis may be seen in conjunction with a variety of other skin disorders due to the complex pathogenesis of atopic dermatitis, involving genetic and environmental factors that are associated with immune dysfunction, barrier defects, and altered skin microbiomes. Skin disorders associated with atopic dermatitis include diseases sharing similar genetic origins like ichthyosis vulgaris, infectious diseases such as impetigo, and eczema herpeticum, in addition to the cutaneous autoimmune diseases, alopecia areata, and vitiligo...
September 2018: Clinics in Dermatology
Stefan Achermann, Per Falås, Adriano Joss, Cresten B Mansfeldt, Yujie Men, Bernadette Vogler, Kathrin Fenner
For many polar organic micropollutants, biotransformation by activated sludge microorganisms is a major removal process during wastewater treatment. However, our current understanding of how wastewater treatment operations influence microbial communities and their micropollutant biotransformation potential is limited, leaving major parts of observed variability in biotransformation rates across treatment facilities unexplained. Here, we present biotransformation rate constants for 42 micropollutants belonging to different chemical classes along a gradient of solids retention time (SRT)...
October 1, 2018: Environmental Science & Technology
Helena Carstensen, Eva Z Hesselkilde, Merle Fenner, Ameli V Loft-Andersen, Mette Flethøj, Jørgen K Kanters, Stefan M Sattler, Jacob Tfelt-Hansen, Steen Pehrson, Thomas Jespersen, Rikke Buhl
BACKGROUND: Pharmacological treatment of atrial fibrillation (AF) in horses can be challenging because of low efficacy and adverse effects. Flecainide has been tested with variable efficacy. OBJECTIVE: To test whether the efficacy of flecainide is dependent on AF duration. ANIMALS: Nine Standardbred mares. METHODS: Factorial study design. All horses were instrumented with a pacemaker and assigned to a control or an AF group...
August 22, 2018: Journal of Veterinary Internal Medicine
Annette Fenner
No abstract text is available yet for this article.
October 2018: Nature Reviews. Urology
Annette Fenner
No abstract text is available yet for this article.
October 2018: Nature Reviews. Urology
Lauren A Jordan, Malin C Erlandsson, Benjamin F Fenner, Ruth Davies, Ann K Harvey, Ernest H Choy, Rachel Errington, Maria I Bokarewa, Anwen S Williams
Objective: Macrophage inflammatory protein 1-alpha (CCL3) is a chemokine that regulates macrophage trafficking to the inflamed joint. The agonistic effect of CCL3 on osteolytic lesions in patients with multiple myeloma is recognized; however, its role in skeletal damage during inflammatory arthritis has not been established. The aim of the study was to explore the role of osteoclast-associated CCL3 upon bone resorption, and to test its pharmacological blockade for protecting against bone pathology during inflammatory arthritis...
July 20, 2018: Rheumatology
Annette Fenner
No abstract text is available yet for this article.
September 2018: Nature Reviews. Urology
Joseph W Jackson, Tim Sparer
Human cytomegalovirus (HCMV) is a β-herpes virus that is a significant pathogen within immune compromised populations. HCMV morbidity is induced through viral dissemination and inflammation. Typically, viral dissemination is thought to follow Fenner's hypothesis where virus replicates at the site of infection, followed by replication in the draining lymph nodes, and eventually replicating within blood filtering organs. Although CMVs somewhat follow Fenner's hypothesis, they deviate from it by spreading primarily through innate immune cells as opposed to cell-free virus...
July 20, 2018: Viruses
Trevor Fenner, Martyn Harris, Mark Levene, Judit Bar-Ilan
We propose the χ-index as a bibliometric indicator that generalises the h-index. While the h-index is determined by the maximum square that fits under the citation curve of an author when plotting the number of citations in decreasing order, the χ-index is determined by the maximum area rectangle that fits under the curve. The height of the maximum rectangle is the number of citations ck to the kth most-cited publication, where k is the width of the rectangle. The χ-index is then defined as [Formula: see text], for convenience of comparison with the h-index and other similar indices...
2018: PloS One
Adam Oest, Ali Alsaffar, Mitchell Fenner, Dominic Azzopardi, Sonia M Tiquia-Arashiro
Information on the biodegradation potential of lake and river microbial communities is essential for watershed management. The water draining into the lake ecosystems often carries a significant amount of suspended sediments, which are transported by rivers and streams from the local drainage basin. The organic carbon processing in the sediments is executed by heterotrophic microbial communities, whose activities may vary spatially and temporally. Thus, to capture and apprehend some of these variabilities in the sediments, we sampled six sites: three from the Saint Clair River (SC1, SC2, and SC3) and three from Lake Saint Clair in the spring, summer, fall, and winter of 2016...
2018: International Journal of Microbiology
Khadija Said, Jerry Hella, Mwajabu Ruzegea, Rajesh Solanki, Magreth Chiryamkubi, Francis Mhimbira, Nicole Ritz, Christian Schindler, Anna M Mandalakas, Karim Manji, Marcel Tanner, Jürg Utzinger, Lukas Fenner
BACKGROUND: Childhood tuberculosis (TB) is acquired following exposure to an infectious TB case, often within the household. We prospectively screened children 6-59 months of age, exposed and unexposed to an infectious TB case within the same household, for latent tuberculosis infection (LTBI), in Dar es Salaam, Tanzania. METHODS: We collected medical data and clinical specimens (to evaluate for helminths, TB and HIV coinfections) and performed physical examinations at enrollment and at 3-month and 6-months follow-up surveys...
June 27, 2018: Pediatric Infectious Disease Journal
Yuxin Wang, Adelene Lai, Diogo Latino, Kathrin Fenner, Damian E Helbling
Aerobic biodegradation half-lives (half-lives) are key parameters used to evaluate pesticide persistence in soil. However, half-life estimates for individual pesticides often span several orders of magnitude, reflecting the impact that various environmental or experimental parameters have on half-lives in soil. In this work, we collected literature-reported half-lives for eleven pesticides along with associated metadata describing the environmental or experimental conditions under which they were derived. We then developed a multivariable framework to discover relationships between the half-lives and associated metadata...
October 2018: Chemosphere
Annette Fenner
No abstract text is available yet for this article.
June 21, 2018: Nature Reviews. Urology
Soledad Berríos, Julio López Fenner, Aude Maignan
We show that an inhomogeneous Bernoulli site percolation process running upon a fullerene's dual [Formula: see text] can be used for representing bivalents attached to the nuclear envelope in mouse Mus M. Domesticus 2n = 40 meiotic spermatocytes during pachytene. It is shown that the induced clustering generated by overlapping percolation domains correctly reproduces the probability distribution observed in the experiments (data) after fine tuning the parameters.
June 19, 2018: Journal of Mathematical Biology
Denise Kühnert, Mireia Coscolla, Daniela Brites, David Stucki, John Metcalfe, Lukas Fenner, Sebastien Gagneux, Tanja Stadler
The fast evolution of pathogenic viruses has allowed for the development of phylodynamic approaches that extract information about the epidemiological characteristics of viral genomes. Thanks to advances in whole genome sequencing, they can be applied to slowly evolving bacterial pathogens like Mycobacterium tuberculosis. In this study, we investigate and compare the epidemiological dynamics underlying two M. tuberculosis outbreaks using phylodynamic methods. Specifically, we (i) test if the outbreak data sets contain enough genetic variation to estimate short-term evolutionary rates and (ii) reconstruct epidemiological parameters such as the effective reproduction number...
May 22, 2018: Epidemics
Jonas Brunner, Michael Stickel, Hartwig Fenner
No abstract text is available yet for this article.
May 4, 2018: Deutsches Ärzteblatt International
Annette Fenner
No abstract text is available yet for this article.
July 2018: Nature Reviews. Urology
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