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Annette Fenner
No abstract text is available yet for this article.
August 9, 2018: Nature Reviews. Urology
Annette Fenner
No abstract text is available yet for this article.
July 31, 2018: Nature Reviews. Urology
Lauren A Jordan, Malin C Erlandsson, Benjamin F Fenner, Ruth Davies, Ann K Harvey, Ernest H Choy, Rachel Errington, Maria I Bokarewa, Anwen S Williams
Objective: Macrophage inflammatory protein 1-alpha (CCL3) is a chemokine that regulates macrophage trafficking to the inflamed joint. The agonistic effect of CCL3 on osteolytic lesions in patients with multiple myeloma is recognized; however, its role in skeletal damage during inflammatory arthritis has not been established. The aim of the study was to explore the role of osteoclast-associated CCL3 upon bone resorption, and to test its pharmacological blockade for protecting against bone pathology during inflammatory arthritis...
July 20, 2018: Rheumatology
Annette Fenner
No abstract text is available yet for this article.
July 23, 2018: Nature Reviews. Urology
Joseph W Jackson, Tim Sparer
Human cytomegalovirus (HCMV) is a β-herpes virus that is a significant pathogen within immune compromised populations. HCMV morbidity is induced through viral dissemination and inflammation. Typically, viral dissemination is thought to follow Fenner's hypothesis where virus replicates at the site of infection, followed by replication in the draining lymph nodes, and eventually replicating within blood filtering organs. Although CMVs somewhat follow Fenner's hypothesis, they deviate from it by spreading primarily through innate immune cells as opposed to cell-free virus...
July 20, 2018: Viruses
Trevor Fenner, Martyn Harris, Mark Levene, Judit Bar-Ilan
We propose the χ-index as a bibliometric indicator that generalises the h-index. While the h-index is determined by the maximum square that fits under the citation curve of an author when plotting the number of citations in decreasing order, the χ-index is determined by the maximum area rectangle that fits under the curve. The height of the maximum rectangle is the number of citations ck to the kth most-cited publication, where k is the width of the rectangle. The χ-index is then defined as [Formula: see text], for convenience of comparison with the h-index and other similar indices...
2018: PloS One
Adam Oest, Ali Alsaffar, Mitchell Fenner, Dominic Azzopardi, Sonia M Tiquia-Arashiro
Information on the biodegradation potential of lake and river microbial communities is essential for watershed management. The water draining into the lake ecosystems often carries a significant amount of suspended sediments, which are transported by rivers and streams from the local drainage basin. The organic carbon processing in the sediments is executed by heterotrophic microbial communities, whose activities may vary spatially and temporally. Thus, to capture and apprehend some of these variabilities in the sediments, we sampled six sites: three from the Saint Clair River (SC1, SC2, and SC3) and three from Lake Saint Clair in the spring, summer, fall, and winter of 2016...
2018: International Journal of Microbiology
Khadija Said, Jerry Hella, Mwajabu Ruzegea, Rajesh Solanki, Magreth Chiryamkubi, Francis Mhimbira, Nicole Ritz, Christian Schindler, Anna M Mandalakas, Karim Manji, Marcel Tanner, Jürg Utzinger, Lukas Fenner
BACKGROUND: Childhood tuberculosis (TB) is acquired following exposure to an infectious TB case, often within the household. We prospectively screened children 6-59 months of age, exposed and unexposed to an infectious TB case within the same household, for latent tuberculosis infection (LTBI), in Dar es Salaam, Tanzania. METHODS: We collected medical data and clinical specimens (to evaluate for helminths, TB and HIV coinfections) and performed physical examinations at enrollment and at 3-month and 6-months follow-up surveys...
June 27, 2018: Pediatric Infectious Disease Journal
Yuxin Wang, Adelene Lai, Diogo Latino, Kathrin Fenner, Damian E Helbling
Aerobic biodegradation half-lives (half-lives) are key parameters used to evaluate pesticide persistence in soil. However, half-life estimates for individual pesticides often span several orders of magnitude, reflecting the impact that various environmental or experimental parameters have on half-lives in soil. In this work, we collected literature-reported half-lives for eleven pesticides along with associated metadata describing the environmental or experimental conditions under which they were derived. We then developed a multivariable framework to discover relationships between the half-lives and associated metadata...
June 14, 2018: Chemosphere
Annette Fenner
No abstract text is available yet for this article.
June 21, 2018: Nature Reviews. Urology
Soledad Berríos, Julio López Fenner, Aude Maignan
We show that an inhomogeneous Bernoulli site percolation process running upon a fullerene's dual [Formula: see text] can be used for representing bivalents attached to the nuclear envelope in mouse Mus M. Domesticus 2n = 40 meiotic spermatocytes during pachytene. It is shown that the induced clustering generated by overlapping percolation domains correctly reproduces the probability distribution observed in the experiments (data) after fine tuning the parameters.
June 19, 2018: Journal of Mathematical Biology
Denise Kühnert, Mireia Coscolla, Daniela Brites, David Stucki, John Metcalfe, Lukas Fenner, Sebastien Gagneux, Tanja Stadler
The fast evolution of pathogenic viruses has allowed for the development of phylodynamic approaches that extract information about the epidemiological characteristics of viral genomes. Thanks to advances in whole genome sequencing, they can be applied to slowly evolving bacterial pathogens like Mycobacterium tuberculosis. In this study, we investigate and compare the epidemiological dynamics underlying two M. tuberculosis outbreaks using phylodynamic methods. Specifically, we (i) test if the outbreak data sets contain enough genetic variation to estimate short-term evolutionary rates and (ii) reconstruct epidemiological parameters such as the effective reproduction number...
May 22, 2018: Epidemics
Jonas Brunner, Michael Stickel, Hartwig Fenner
No abstract text is available yet for this article.
May 4, 2018: Deutsches Ärzteblatt International
Annette Fenner
No abstract text is available yet for this article.
July 2018: Nature Reviews. Urology
Lukas Fenner, Anja Kässner, Claudia Berlin, Matthias Egger, Marcel Zwahlen
AIMS: Breast cancer is the most common cancer in women worldwide. We assessed changes in the use of breast cancer screening 2007-2012 in Switzerland, and associations with socioeconomic and health-related determinants. METHODS: We used the nationwide and representative data from the Swiss Health Surveys 2007 and 2012. We analysed the self-reported use of mammography in the last 12 months (proportion of population) among women aged 40-79 years, and opportunistic (without clinical symptoms, initiated by the woman or a physician) and programmatic screening mammography (as part of a systematic screening programme)...
2018: Swiss Medical Weekly
Rikke Buhl, Helena Carstensen, Eva Zander Hesselkilde, Bjørg Zinkernagel Klein, Karen Margrethe Hougaard, Kirsten Bomberg Ravn, Ameli Victoria Loft-Andersen, Merle Friederike Fenner, Christian Pipper, Thomas Jespersen
BACKGROUND: Atrial fibrillation (AF) is the most common arrhythmia affecting performance in horses. However, no previous studies have quantified the performance reduction in horses suffering from AF. OBJECTIVES: To quantify the effect of AF on maximum velocity (Vmax ), maximum heart rate (HRmax ), heart rate recovery (T100 ), hematologic parameters and development of abnormal QRS complexes. ANIMALS: Nine Standardbred trotters. METHODS: Two-arm controlled trial...
May 10, 2018: Journal of Veterinary Internal Medicine
Jonathan Christopher Taylor, Charles Romanowski, Eleanor Lorenz, Christine Lo, Oliver Bandmann, John Fenner
BACKGROUND: For (123 I)FP-CIT imaging, a number of algorithms have shown high performance in distinguishing normal patient images from those with disease, but none have yet been tested as part of reporting workflows. This study aims to evaluate the impact on reporters' performance of a computer-aided diagnosis (CADx) tool developed from established machine learning technology. Three experienced (123 I)FP-CIT reporters (two radiologists and one clinical scientist) were asked to visually score 155 reconstructed clinical and research images on a 5-point diagnostic confidence scale (read 1)...
May 8, 2018: EJNMMI Research
Ling Zou, Adrian Stecula, Anshul Gupta, Bhagwat Prasad, Huan-Chieh Chien, Sook Wah Yee, Li Wang, Jashvant D Unadkat, Simone H Stahl, Katherine S Fenner, Kathleen M Giacomini
Species differences in renal drug transporters continue to plague drug development with animal models failing to adequately predict renal drug toxicity. For example, adefovir, a renally excreted antiviral drug, failed clinical studies for human immunodeficiency virus due to pronounced nephrotoxicity in humans. In this study, we demonstrated that there are large species differences in the kinetics of interactions of a key class of antiviral drugs, acyclic nucleoside phosphonates (ANPs), with organic anion transporter 1 [(OAT1) SLC22A6] and identified a key amino acid residue responsible for these differences...
July 2018: Molecular Pharmacology
Stefan Achermann, Valeria Bianco, Cresten B Mansfeldt, Bernadette Vogler, Boris A Kolvenbach, Philippe F X Corvini, Kathrin Fenner
The presence of antibiotics in treated wastewater and consequently in surface and groundwater resources raises concerns about the formation and spread of antibiotic resistance. Improving the removal of antibiotics during wastewater treatment therefore is a prime objective of environmental engineering. Here we obtained a detailed picture of the fate of sulfonamide antibiotics during activated sludge treatment using a combination of analytical methods. We show that pterin-sulfonamide conjugates, which are formed when sulfonamides interact with their target enzyme to inhibit folic acid synthesis, represent a major biotransformation route for sulfonamides in laboratory batch experiments with activated sludge...
June 5, 2018: Environmental Science & Technology
M F Fenner, D Verwilghen, N Townsend, H Simhofer, J Schwarzer, D D Zani, A Bienert-Zeit
BACKGROUND: Paranasal sinus cysts (PSC) are a common cause of equine secondary sinusitis. The outcome and associated complications have not been frequently reported. OBJECTIVES: To review the associated clinical signs, associated morbidities and outcomes of horses treated for PSC. STUDY DESIGN: Retrospective multicentre case series. METHODS: Retrospective analysis of case records and telephone follow up survey. RESULTS: Subjects were 37 horses 1-24 years old that were presented with nasal discharge (n = 31), facial swelling (n = 25) and epiphora (n = 19)...
April 20, 2018: Equine Veterinary Journal
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