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https://www.readbyqxmd.com/read/30324578/the-benefits-of-angiotensin-converting-enzyme-inhibitors-angiotensin-ii-receptor-blockers-combined-with-calcium-channel-blockers-on-metabolic-renal-and-cardiovascular-outcomes-in-hypertensive-patients-a-meta-analysis
#1
Punnaka Pongpanich, Pasvich Pitakpaiboonkul, Kullaya Takkavatakarn, Kearkiat Praditpornsilpa, Somchai Eiam-Ong, Paweena Susantitaphong
BACKGROUND: The prevalence of hypertension and its associated complications are markedly growing. Most patients need more than one drug to achieve blood pressure (BP) target. However, most guidelines only focus on the first-line treatment. We conducted a meta-analysis to explore the benefits of angiotensin-converting enzyme inhibitors (ACEIs)/angiotensin II receptor blockers (ARBs) combined with calcium channel blockers (CCBs) on metabolic, renal, and cardiovascular outcomes in hypertensive patients...
October 15, 2018: International Urology and Nephrology
https://www.readbyqxmd.com/read/30321910/epidermal-growth-factor-receptor-blockers-for-the-treatment-of-ovarian-cancer
#2
REVIEW
Jo Morrison, Clemens Thoma, Richard J Goodall, Thomas J Lyons, Kezia Gaitskell, Alison J Wiggans, Andrew Bryant
BACKGROUND: This is an update of a previously published version of the review (Issue 10, 2011).Epithelial ovarian cancer (EOC) is the seventh most common cause of cancer death among women worldwide. Treatment consists of a combination of surgical debulking and platinum-based chemotherapy. Between 55% and 75% of women who respond to first-line therapy experience relapse within two years. Second-line chemotherapy is palliative and aims to reduce symptoms and prolong survival. Improved understanding about the molecular basis of EOC has led to the development of novel agents, such as epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors and anti-EGFR antibodies...
October 16, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/30318915/hip-spine-syndrome-cross-sectional-study-of-spinal-alignment-in-patients-with-coxalgia
#3
Masayuki Miyagi, Kensuke Fukushima, Gen Inoue, Toshiyuki Nakazawa, Takayuki Imura, Wataru Saito, Naonobu Takahira, Masashi Takaso
INTRODUCTION: Patients presenting with hip diseases often have coexisting spine disorders, a condition that is termed "hip-spine syndrome." However, few reports have evaluated total spinal alignments in patients with coxalgia. In this study, we retrospectively examined the relationship between several clinical and x-ray parameters of the hip joints and spinal alignment in patients with coxalgia. METHODS: 100 patients with coxalgia (24 men, 76 women; average age, 60...
October 14, 2018: Hip International: the Journal of Clinical and Experimental Research on Hip Pathology and Therapy
https://www.readbyqxmd.com/read/30318105/pulmonary-arterial-pressure-management-based-on-oral-medicine-for-pediatric-living-donor-liver-transplant-with-portopulmonary-hypertension
#4
T Ueno, S Hiwatashi, R Saka, H Yamanaka, Y Takama, Y Tazuke, K Bessho, S Kogaki, T Yonekura, H Okuyama
Pediatric living donor liver transplantation (LDLT) in patients with advanced portopulmonary hypertension (PoPH) is associated with poor prognoses. Recently, novel oral medications, including endothelin receptor antagonists (ERAs), phosphodiesterase 5 (PDE5) inhibitors, and oral prostacyclin (PGI2) have been used to treat PoPH. Pediatric patients with PoPH who underwent LDLT from 2006 to 2016 were enrolled. Oral pulmonary hypertension (PH) medication was administered to control pulmonary arterial pressure (PAP)...
March 15, 2018: Transplantation Proceedings
https://www.readbyqxmd.com/read/30315622/lessons-learned-from-a-hospital-wide-review-of-blood-stream-infections-for-paediatric-central-line-associated-blood-stream-infection-prevention
#5
Anita J Campbell, Christopher C Blyth, Christopher J Hewison, Yu-Ping Chen, Leanne Gough, Zoy Goff, Asha C Bowen
AIM: Bacteraemia episodes were assessed to calculate a hospital-wide central line-associated blood stream infection (CLABSI) rate per 1000 catheter-days. Secondary objectives were to describe risk factors, microbiology and outcomes of children with CLABSI. METHODS: A retrospective study was conducted at an Australian tertiary paediatric hospital in children <18 years who had blood culture sampling during the 2-year period, 2014-2015. All blood culture results were extracted from the hospital's laboratory information system...
October 13, 2018: Journal of Paediatrics and Child Health
https://www.readbyqxmd.com/read/30314897/mitochondrial-enzyme-glud2-plays-a-critical-role-in-glioblastoma-progression
#6
Sara Franceschi, Debora Corsinovi, Francesca Lessi, Elena Tantillo, Paolo Aretini, Michele Menicagli, Claudia Scopelliti, Prospero Civita, Francesco Pasqualetti, Antonio G Naccarato, Michela Ori, Chiara M Mazzanti
BACKGROUND: Glioblastoma (GBM) is the most frequent and malignant primary brain tumor in adults and despite the progress in surgical procedures and therapy options, the overall survival remains very poor. Glutamate and α-KG are fundamental elements necessary to support the growth and proliferation of GBM cells. Glutamate oxidative deamination, catalyzed by GLUD2, is the predominant pathway for the production of α-KG. METHODS: GLUD2 emerged from the RNA-seq analysis of 13 GBM patients, performed in our laboratory and a microarray analysis of 77 high-grade gliomas available on the Geo database...
October 9, 2018: EBioMedicine
https://www.readbyqxmd.com/read/30306523/pain-associated-neural-plasticity-in-the-parabrachial-to-central-amygdala-circuit-pain-changes-the-brain-and-the-brain-changes-the-pain
#7
Fusao Kato, Yae K Sugimura, Yukari Takahashi
In addition to the canonical spino-thalamo-cortical pathway, lines of recently accumulated anatomical and physiological evidence suggest that projections originating in nociception-specific neurons in lamina I of the dorsal horn or the spinal nucleus of the trigeminal nerve to the lateral parabrachial nucleus (LPB) and then to the central amygdala (CeA) play essential roles in the nociception-emotion link and its tightening in chronic pain. With recent advances in the artificial manipulation of central neuronal activity, such as those with optogenetics, it is now possible to address many unanswered questions regarding the molecular and cellular mechanisms underlying the plastic changes in this pathway and their role in the pain chronification process...
2018: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/30305194/interventions-to-reduce-unnecessary-central-venous-catheter-use-to-prevent-central-line-associated-bloodstream-infections-in-adults-a-systematic-review
#8
Zhaoyu Xiong, Haiyan Chen
OBJECTIVE: To identify, describe, and evaluate interventions to reduce unnecessary central venous catheter (CVC) use to prevent central-line-associated bloodstream infections (CLABSIs) in adults. DESIGN: Systematic review. METHODS: The review has been registered in PROSPERO, an international prospective register of systematic reviews. We searched PubMed, EMBASE, the Cochrane Central Register of Controlled Trials (CENTRAL), and the Cumulative Index to Nursing and Allied Health (CINAHL) from inception until August 28, 2018, to collect experimental and observational studies...
October 11, 2018: Infection Control and Hospital Epidemiology
https://www.readbyqxmd.com/read/30302608/yes-associated-protein-yap-molecule-expression-in-odontogenic-epithelium-of-ameloblastoma
#9
Rahul Anand, Sachin C Sarode, Gargi S Sarode, Ladu Singh Rajpurohit, Shankargouda Patil
OBJECTIVES: YAP (Yes-associated protein molecule) augments multiple processes known to be important for tumor progression and metastasis. Hence, the application of YAP as a targeted therapy for several malignancies has been documented in the literature. Ameloblastoma being a locally invasive odontogenic lesion causes tissue destruction and presents with a great chance of recurrence. Based on these qualities, we hypothesized that YAP could exhibit increased expression in the odontogenic epithelium of ameloblastoma...
October 9, 2018: Clinical Oral Investigations
https://www.readbyqxmd.com/read/30301731/ascites-with-hepatic-extravasation-of-total-parenteral-nutrition-tpn-secondary-to-umbilical-venous-catheter-uvc-malposition-in-an-extremely-preterm-baby
#10
Satyaranjan Pegu, Poornima Murthy
The ease of access and advantages of a secure central line makes use of umbilical venous catheter (UVC) and umbilical artery catheters a part of the standard of care in the extremely premature babies in the neonatal intensive care unit. However, there are complications associated with their use. One of the uncommon complications reported is total parenteral nutrition (TPN) ascites secondary to vessel perforation or hepatic erosion by the tip of the catheter due to malposition of a UVC. We present here a case of such catheter perforation causing ascites and right hepatic collection of TPN in a 28-week-old infant...
October 8, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/30300440/pharmacokinetics-of-the-meropenem-component-of-meropenem-vaborbactam-in-the-treatment-of-kpc-producing-klebsiella-pneumoniae-bloodstream-infection-in-a-pediatric-patient
#11
Alexandra M Hanretty, Ishminder Kaur, Alan T Evangelista, Wayne S Moore, Adela Enache, Arun Chopra, Jeffrey J Cies
INTRODUCTION: Meropenem-vaborbactam is a new β-lactam/β-lactamase inhibitor combination designed to target Klebsiella pneumoniae carbapenemase (KPC)-producing Enterobacteriaceae. Meropenem-vaborbactam was Food and Drug Administration FDA approved for complicated urinary tract infections (cUTI) in patients 18 years of age or older. An understanding of the pharmacokinetics of meropenem when given in combination with vaborbactam is important to understanding the dosing of meropenem-vaborbactam...
October 9, 2018: Pharmacotherapy
https://www.readbyqxmd.com/read/30297010/infection-prevention-for-the-emergency-department-out-of-reach-or-standard-of-care
#12
REVIEW
Stephen Y Liang, Madison Riethman, Josephine Fox
The emergency department (ED) presents unique challenges to infection control and prevention. Hand hygiene, transmission-based precautions, environmental cleaning, high-level disinfection and sterilization of reusable medical devices, and prevention of health care-associated infections (catheter-associated urinary tract infection, ventilator-associated pneumonia, central line-associated bloodstream infection) are key priorities in ED infection prevention. Effective and sustainable infection prevention strategies tailored to the ED are necessary and achievable...
November 2018: Emergency Medicine Clinics of North America
https://www.readbyqxmd.com/read/30294508/transkingdom-network-reveals-bacterial-players-associated-with-cervical-cancer-gene-expression-program
#13
Khiem Chi Lam, Dariia Vyshenska, Jialu Hu, Richard Rosario Rodrigues, Anja Nilsen, Ryszard A Zielke, Nicholas Samuel Brown, Eva-Katrine Aarnes, Aleksandra E Sikora, Natalia Shulzhenko, Heidi Lyng, Andrey Morgun
Cervical cancer is the fourth most common cancer in women worldwide with human papillomavirus (HPV) being the main cause the disease. Chromosomal amplifications have been identified as a source of upregulation for cervical cancer driver genes but cannot fully explain increased expression of immune genes in invasive carcinoma. Insight into additional factors that may tip the balance from immune tolerance of HPV to the elimination of the virus may lead to better diagnosis markers. We investigated whether microbiota affect molecular pathways in cervical carcinogenesis by performing microbiome analysis via sequencing 16S rRNA in tumor biopsies from 121 patients...
2018: PeerJ
https://www.readbyqxmd.com/read/30293206/aggressiveness-of-localized-prostate-cancer-the-key-value-of-testosterone-deficiency-evaluated-by-both-total-and-bioavailable-testosterone-androcan-study-results
#14
Yann Neuzillet, Jean-Pierre Raynaud, Jean-François Dreyfus, Camélia Radulescu, Mathieu Rouanne, Marc Schneider, Sylvie Krish, Morgan Rouprêt, Sarah J Drouin, Eva Comperat, Marc Galiano, Xavier Cathelineau, Pierre Validire, Vincent Molinié, Jean Fiet, Franck Giton, Thierry Lebret, Henry Botto
Failure rates after first-line treatment of localized prostate cancer (PCa) treatment remain high. Improvements to patient selection and identification of at-risk patients are central to reducing mortality. We aimed to determine if cancer aggressiveness correlates with androgen levels in patients undergoing radical prostatectomy for localized PCa. We performed a prospective, multicenter cohort study between June 2013 and June 2016, involving men with localized PCa scheduled to undergo radical prostatectomy...
October 6, 2018: Hormones & Cancer
https://www.readbyqxmd.com/read/30292482/clinical-outcomes-of-home-parenteral-nutrition-patients-using-taurolidine-as-catheter-lock-a-long-term-cohort-study
#15
Yannick Wouters, Britt Roosenboom, Erna Causevic, Wietske Kievit, Hans Groenewoud, Geert J A Wanten
BACKGROUND & AIMS: Central venous access device (CVAD)-related complications, such as central-line associated bloodstream infections (CLABSIs), CVAD-related venous thromboses (CRVTs) and -occlusions frequently occur in home parenteral nutrition (HPN) patients. A preventive strategy to decrease the incidence of CLABSIs is the use of CVAD lock solutions, such as 2% taurolidine. The aim of this study was to evaluate long-term clinical outcomes of our HPN cohort while using taurolidine as lock solution...
September 20, 2018: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/30290903/intensive-treatment-strategies-in-advanced-stage-hodgkin-s-lymphoma-hd9-and-hd12-analysis-of-long-term-survival-in-two-randomised-trials
#16
Bastian von Tresckow, Stefanie Kreissl, Helen Goergen, Paul J Bröckelmann, Thomas Pabst, Michael Fridrik, Mathias Rummel, Wolfram Jung, Julia Thiemer, Stephanie Sasse, Carolin Bürkle, Christian Baues, Volker Diehl, Andreas Engert, Peter Borchmann
BACKGROUND: Although intensified chemotherapy regimens have improved tumour control and survival in advanced-stage Hodgkin's lymphoma, data on the long-term sequelae are scarce. We did preplanned follow-up analyses of the German Hodgkin Study Group (GHSG) trials HD9 and HD12 to assess whether the primary results of these trials-which had shown that intensive initial therapy in advanced-stage Hodgkin's lymphoma has a beneficial effect on treatment outcomes-would continue with longer follow-up...
October 2018: Lancet Haematology
https://www.readbyqxmd.com/read/30290306/protecting-pax6-3-utr-from-microrna-7-partially-restores-pax6-in-islets-from-an-aniridia-mouse-model
#17
Kevin Yongblah, Spencer C Alford, Bridget C Ryan, Robert L Chow, Perry L Howard
Aniridia is a rare congenital syndrome that is associated with reduced visual acuity and progressive loss of vision. Aniridia patients may also develop systemic health issues associated with defects in the pancreas, digestive, and central nervous systems. The spectrum of symptoms associated with aniridia is due to haploinsufficiency of the paired box 6 gene (PAX6) and its role in the development and maintenance of the affected tissues. Here, we isolated pancreatic islets from mice heterozygous for Pax6 to test whether a Pax6-specific miRNA suppression (target protector) strategy can restore PAX6 protein levels...
September 1, 2018: Molecular Therapy. Nucleic Acids
https://www.readbyqxmd.com/read/30284632/isolation-identification-and-classification-of-a-novel-rhabdovirus-from-diseased-chinese-rice-field-eels-monopterus-albus
#18
Wenzhi Liu, Yuding Fan, Zhong Li, Jianqing Zhao, Yong Zhou, Nan Jiang, Jia Zeng, Kenneth Cain, Lingbing Zeng
In 2017, a clinical disease outbreak resulted in substantial mortality of adults and larvae of cultured Chinese rice-field eels (Monopterus albus) on a farm in Hubei, Central China. A rhabdovirus was isolated from moribund specimens, and typical clinical symptoms associated with an outbreak included an enlarged and swollen head. This differed from previous observations. Histological changes included necrosis and cavities of various sizes within the brain and kidney. Homogenized tissues of diseased Chinese rice-field eels were screened for viral isolation using six different fish cell lines...
October 4, 2018: Archives of Virology
https://www.readbyqxmd.com/read/30282021/single-cell-analysis-of-quiescent-hiv-infection-reveals-host-transcriptional-profiles-that-regulate-proviral-latency
#19
Todd Bradley, Guido Ferrari, Barton F Haynes, David M Margolis, Edward P Browne
A detailed understanding of the mechanisms that establish or maintain the latent reservoir of HIV will guide approaches to eliminate persistent infection. We used a cell line and primary cell models of HIV latency to investigate viral RNA (vRNA) expression and the role of the host transcriptome using single-cell approaches. Single-cell vRNA quantitation identified distinct populations of cells expressing various levels of vRNA, including completely silent populations. Strikingly, single-cell RNA-seq of latently infected primary cells demonstrated that HIV downregulation occurred in diverse transcriptomic environments but was significantly associated with expression of a specific set of cellular genes...
October 2, 2018: Cell Reports
https://www.readbyqxmd.com/read/30281074/locking-hemodialysis-catheters-with-trimethoprim-ethanol-ca-edta-to-prevent-bloodstream-infections-a-randomized-evaluator-blinded-clinical-trial
#20
Bart Rijnders, Gino DiSciullo, Botond Csiky, Boleslaw Rutkowski, Krzysztof Appelt, John Cheronis, Roger Aitchison, Gilad Gordon, Michel Jadoul, Richard Fluck
Background: Central line associated bloodstream infections(CLABSI) often result from intraluminal microbial colonization and are associated with morbidity, mortality, and substantial costs. The use of antimicrobial catheter lock solutions may reduce the incidence of CLABSI. Methods: Patients undergoing hemodialysis through a prevalent central venous catheter(CVC) were randomly assigned to have their CVC locked between dialysis sessions with an antimicrobial catheter lock solution containing trimethoprim 5 mg/mL, Ethanol 25% and Ca-EDTA 3%(Investigational Medical Device, IMD) or heparin 5,000 U/mL(Active Control Heparin, ACH)...
October 3, 2018: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
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