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https://www.readbyqxmd.com/read/30115913/transcriptomic-signatures-of-schizophrenia-revealed-by-dopamine-perturbation-in-an-ex-vivo-model
#1
Jubao Duan, Harald H H Göring, Alan R Sanders, Winton Moy, Jessica Freda, Eugene I Drigalenko, Mark Kos, Deli He, Pablo V Gejman
The dopaminergic hypothesis of schizophrenia (SZ) postulates that dopaminergic over activity causes psychosis, a central feature of SZ, based on the observation that blocking dopamine (DA) improves psychotic symptoms. DA is known to have both receptor- and non-receptor-mediated effects, including oxidative mechanisms that lead to apoptosis. The role of DA-mediated oxidative processes in SZ has been little studied. Here, we have used a cell perturbation approach and measured transcriptomic profiles by RNAseq to study the effect of DA exposure on transcription in B-cell transformed lymphoblastoid cell lines (LCLs) from 514 SZ cases and 690 controls...
August 16, 2018: Translational Psychiatry
https://www.readbyqxmd.com/read/30115664/preclinical-efficacy-of-the-novel-monocarboxylate-transporter-1-inhibitor-bay-8002-and-associated-markers-of-resistance
#2
Maria Quanz, Eckhard Bender, Charlotte Kopitz, Sylvia Grünewald, Andreas Schlicker, Wolfgang Schwede, Ashley Eheim, Luisella Toschi, Roland Neuhaus, Carmen Richter, Joern Toedling, Claudia Merz, Ralf Lesche, Atanas Kamburov, Holger Siebeneicher, Marcus Bauser, Andrea Haegebarth
The lactate transporter SLC16A1/MCT1 plays a central role in tumor cell energy homeostasis. In a cell based screen, we identified a novel class of monocarboxylate transporter 1 (MCT1) inhibitors, including BAY-8002, which potently suppress bidirectional lactate transport. We investigated the antiproliferative activity of BAY-8002 in a panel of 246 cancer cell lines and show that hematopoietic tumor cells, in particular diffuse large B-cell lymphoma cell lines, and subsets of solid tumor models are particularly sensitive to MCT1 inhibition...
August 16, 2018: Molecular Cancer Therapeutics
https://www.readbyqxmd.com/read/30112254/fidaxomicin-vs-vancomycin-for-the-treatment-of-a-first-episode-of-clostridium-difficile-infection-a-meta-analysis-and-systematic-review
#3
REVIEW
Laith A Al Momani, Omar Abughanimeh, Boonphiphop Boonpheng, Joseph Gabriel Gabriel, Mark Young
Clostridium difficile infection (CDI) continues to possess a significant disease burden in the United States (US) as well as all over the world. Given the increase in severity and recurrence rate, the decrease in cure rate, and the fact that the virulent ribotype 027 strain remains one of the most commonly identified strains in the US, the Infectious Diseases Society of America (IDSA) published a clinical practice guideline in February 2018 moving away from metronidazole as the first-line treatment for initial CDI and recommending either oral vancomycin or fidaxomicin...
June 11, 2018: Curēus
https://www.readbyqxmd.com/read/30111976/perceptions-of-vascular-access-for-intravenous-systemic-therapy-and-risk-factors-for-lymphedema-in-early-stage-breast-cancer-a-patient-survey
#4
N LeVasseur, C Stober, M Ibrahim, S Gertler, J Hilton, A Robinson, S McDiarmid, D Fergusson, S Mazzarello, B Hutton, A A Joy, M McInnes, M Clemons
Background: The choice of vascular access for systemic therapy administration in breast cancer remains an area of clinical equipoise, and patient preference is not consistently acknowledged. Using a patient survey, we evaluated the patient experience with vascular access during treatment for early-stage breast cancer and explored perceived risk factors for lymphedema. Methods: Patients who had received systemic therapy for early-stage breast cancer were surveyed at 2 Canadian cancer centres...
August 2018: Current Oncology
https://www.readbyqxmd.com/read/30111975/optimizing-vascular-access-for-patients-receiving-intravenous-systemic-therapy-for-early-stage-breast-cancer-a-survey-of-oncology-nurses-and-physicians
#5
N LeVasseur, C Stober, K Daigle, A Robinson, S McDiarmid, S Mazzarello, B Hutton, A Joy, D Fergusson, J Hilton, M McInnes, M Clemons
Background: Despite advances in systemic therapy choices for patients with early-stage breast cancer, optimal practices for intravenous (IV) access remain unknown. That lack of knowledge holds particularly true for the use of central venous access devices (cvads) such as peripherally inserted central catheters (piccs) and implanted vascular access devices (ports). Methods: Using a survey of Canadian oncologists and oncology nurses responsible for the care of breast cancer patients, we evaluated current access practices, perceptions of complications, and perceptions of risk, and we estimated complication rates and evaluated perceived risk factors for lymphedema...
August 2018: Current Oncology
https://www.readbyqxmd.com/read/30111931/the-era-of-device-colonizers-chryseobacterium-indologenes-infections-from-a-tertiary-care-center-in-north-india
#6
Vidhi Jain, Chinmoy Sahu, Nayani Amrin Fatema Afzal Hussain, Malay Ghar, Kashi Nath Prasad
Background: Chryseobacterium indologenes is a hospital environment contaminant and can cause healthcare-associated infections. Methods: Patients with C. indologenes infections in a tertiary care center in North India for 6 months were evaluated for susceptibility patterns, comorbidities, mechanical devices, risk factors, and treatment outcomes. The organism was provisionally identified phenotypically, and identification was confirmed by the BD Phoenix automated microbiology system...
July 2018: Indian Journal of Critical Care Medicine
https://www.readbyqxmd.com/read/30108104/validation-of-mir-31-3p-expression-to-predict-cetuximab-efficacy-when-used-as-first-line-treatment-in-ras-wild-type-metastatic-colorectal-cancer
#7
Pierre Laurent-Puig, Marie-Lise Grisoni, Volker Heinemann, Francois Liebaert, Daniel Neureiter, Andreas Jung, François Montestruc, Yann Gaston-Mathe, Raphaële Thiébaut, Sebastian Stintzing
PURPOSE: MiR-31-3p expression has been shown to be associated with response to anti-EGFR therapy. We investigated the predictive role of this biomarker in the FIRE-3 study population, including its ability to differentiate outcomes between patients receiving anti-EGFR and anti-VEGF therapy. EXPERIMENTAL DESIGN: MiR-31-3p expression was measured in primary tumors obtained from 340 RAS WT mCRC patients enrolled in the FIRE-3 Trial. This included 164 patients randomized to receive FOLFIRI plus cetuximab (FOLFIRI+Cetux) and 176 to FOLFIRI plus bevacizumab (FOLFIRI+Beva)...
August 14, 2018: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/30106869/true-versus-false-bacteremia-in-infants-and-children-less-than-3-years-of-age
#8
Elizabeth Mannino Avila, Erin Stucky Fisher, Kyung Rhee
OBJECTIVE: The objective of this study was to examine patient history as well as clinical and laboratory features associated with true bacteremia versus false bacteremia in previously healthy febrile children ages 0 to 36 months in the era of polyvalent conjugate pneumococcal immunization. METHODS: Using retrospective chart review, we examined history, physical examination, and laboratory characteristics associated with true and false bacteremia. We included subjects under 3 years old, with a positive blood culture obtained in the emergency department or clinic from July 2011 to July 2013, and fever defined as a temperature of greater than or equal to 100...
August 13, 2018: Pediatric Emergency Care
https://www.readbyqxmd.com/read/30106667/do-perineuronal-net-elements-contribute-to-pathophysiology-of-spinal-muscular-atrophy-in-vitro-and-transcriptomics-insights
#9
Didem Dayangac-Erden, Bala Gur-Dedeoglu, Fatma Nazli Eskici, Yasemin Oztemur-Islakoglu, Sevim Erdem-Ozdamar
Spinal muscular atrophy (SMA) is one of the most common childhood onset neurodegenerative disorders in global health whereby novel biomarkers and therapeutic targets are sorely needed. SMA is an autosomal recessive genetic disorder resulting in degeneration of α-motor neurons in the brain stem and spinal cord that leads to mortality in infants worldwide. In majority of the patients, SMA is caused by homozygous deletion of the SMN1 gene. The clinical spectrum of the SMA displays, however, large person-to-person variations where the underlying mechanisms are poorly understood...
August 14, 2018: Omics: a Journal of Integrative Biology
https://www.readbyqxmd.com/read/30101838/intracellular-localization-of-gga-accessory-protein-p56-in-cell-lines-and-central-nervous-system-neurons
#10
Takefumi Uemura, Naoki Sawada, Takao Sakaba, Satoshi Kametaka, Masaya Yamamoto, Satoshi Waguri
Adaptor protein complex-1 (AP-1) and Golgi associated, γ-adaptin ear containing, Arf binding proteins (GGAs) are clathrin adaptors that regulate membrane trafficking between the trans-Golgi network (TGN) and endosomes. p56 is a clathrin adaptor accessory protein that may modulate the function of GGAs in mammalian cell lines. However, the precise relationship between p56 and the three GGAs (GGA1-3), as well as the physiological role of p56 in tissue cells, remain unknown. To this end, we generated an antibody against p56 and determined its cellular localization...
2018: Biomedical Research
https://www.readbyqxmd.com/read/30100999/chk1-inhibition-as-a-novel-therapeutic-strategy-in-melanoma
#11
Bor-Jang Hwang, Gautam Adhikary, Richard L Eckert, A-Lien Lu
Melanoma patients respond poorly to chemotherapies because they acquire drug resistance. Therapies that can overcome the resistance to inhibitors of the mutated BRAF protein kinase in melanoma are urgently needed. Chk1 protein kinase is a central component of the DNA damage response and plays a crucial role in controlling cell cycle progression. Analyses indicate that low mRNA expression of Chk1 is significantly associated with good overall survival of melanoma patients. To evaluate the effectiveness of Chk1 inhibitors in melanoma therapy, we have generated BRAF inhibitor (PLX4032 or vemurafenib) resistant melanoma cell lines (A375-PLX-R and WM9-PLX-R) from A375 and WM9, respectively...
July 13, 2018: Oncotarget
https://www.readbyqxmd.com/read/30098743/special-considerations-for-the-septic-patient-going-to-the-operating-room
#12
REVIEW
Juanita L Derouen
Perioperative care of the septic patient presents unique challenges for the nurse. Understanding the physiology of sepsis is important for the nurse to anticipate the physiologic changes associated with the disorder and to prioritize the patient's needs. Ensuring adequate intravenous access by peripheral or central venous access as well as anticipating potential invasive monitoring lines allows the nurse to quickly administer antibiotic therapy, initiate fluid resuscitation, and prepare for potential vasopressor use...
September 2018: Critical Care Nursing Clinics of North America
https://www.readbyqxmd.com/read/30097713/non-participation-in-breast-cancer-screening-among-previous-cancer-patients
#13
Line Flytkjær Virgilsen, Anette Fischer Pedersen, Berit Andersen, Peter Vedsted
PURPOSE: Breast cancer can be detected at early stages through organised screening. This study explored reasons for non-participation in breast cancer screening among previous cancer patients, who have high risk of developing a new primary cancer. METHOD: We conducted a population-based historical cohort study, including all women invited to the first organised screening round in 2008-2009 in the Central Denmark Region (n = 149,234). All data were based on national registers...
August 10, 2018: Journal of Cancer Research and Clinical Oncology
https://www.readbyqxmd.com/read/30095499/complication-and-failures-of-central-vascular-access-device-in-adult-critical-care-settings
#14
Mari Takashima, Jessica Schults, Gabor Mihala, Amanda Corley, Amanda Ullman
OBJECTIVES: To examine the proportion and rate of central venous access device failure and complications across central venous access device types in adult intensive care. DATA SOURCES: A systematic search was undertaken in the electronic databases Cochrane Central Register of Controlled Trials (CENTRAL), Embase, U.S. National Library of Medicine National Institutes of Health (MEDLINE), and Cumulative Index to Nursing and Allied Health (CINAHL) in September 2017...
August 7, 2018: Critical Care Medicine
https://www.readbyqxmd.com/read/30091022/impact-of-front-line-relative-dose-intensity-for-methotrexate-and-comorbidities-in-immunocompetent-elderly-patients-with-primary-central-nervous-system-lymphoma
#15
Jonathan Farhi, Kamel Laribi, Corentin Orvain, Jean-François Hamel, Mélanie Mercier, Aurélien Sutra Del Galy, Aline Clavert, Marie-Christine Rousselet, Aline Tanguy-Schmidt, Mathilde Hunault-Berger, Marie-Pierre Moles-Moreau
Primary central nervous system lymphomas (PCNSL) are non-Hodgkin lymphomas strictly localized to the CNS, occurring mainly in elderly patients with comorbidities. Current treatment in fit patients relies on high-dose methotrexate and high-dose cytarabine. The aim of this study was to evaluate the efficacy and feasibility of this treatment in elderly patients and to assess potential prognostic factors associated with survival. We conducted a retrospective study in two centers between January 2008 and September 2015 including 35 elderly immunocompetent patients who received first-line treatment with high-dose methotrexate...
August 8, 2018: Annals of Hematology
https://www.readbyqxmd.com/read/30090837/impact-of-a-multidisciplinary-infection-prevention-initiative-on-central-line-and-urinary-catheter-utilization-in-a-long-term-acute-care-hospital
#16
Suganya Chandramohan, Bhagyashri Navalkele, Ammara Mushtaq, Amar Krishna, John Kacir, Teena Chopra
Background: Prolonged central line (CL) and urinary catheter (UC) use can increase risk of central line-associated bloodstream infection (CLABSI) and catheter-associated urinary tract infection (CAUTI). Methods: This interventional study conducted in a 76-bed long-term acute care hospital (LTACH) in Southeast Michigan was divided into 3 periods: pre-intervention (January 2015-June 2015), intervention (July-November 2015), and postintervention (December 2015-March 2017)...
July 2018: Open Forum Infectious Diseases
https://www.readbyqxmd.com/read/30087855/atezolizumab-for-the-first-line-treatment-of-non-small-cell-lung-cancer-nsclc-current-status-and-future-prospects
#17
REVIEW
Rachel Ryu, Kristina E Ward
Purpose: Atezolizumab is a programmed death ligand 1 (PDL-1) blocking antibody that was approved for metastatic non-small cell lung cancer (NSCLC) in patients with disease progression. Various studies have been initiated to explore the effectiveness of atezolizumab among different patient cohorts and disease statuses, including as first-line therapy. The purpose of this paper is to identify and summarize the trials that use atezolizumab as a first-line agent in chemotherapy-naïve patients with NSCLC. Methods: A database search was performed on Pubmed, Embase, and Wiley Cochrane Library-Central Register of Controlled Trials to identify clinical trials using atezolizumab as first-line therapy in NSCLC...
2018: Frontiers in Oncology
https://www.readbyqxmd.com/read/30086759/il-8-cxcr1-2-signalling-promotes-tumor-cell-proliferation-invasion-and-vascular-mimicry-in-glioblastoma
#18
Ira Sharma, Avninder Singh, Fouzia Siraj, Sunita Saxena
BACKGROUND: Glioblastoma multiforme (GBM) is one of the lethal malignant tumors of the central nervous system. Despite advances made in understanding this complex disease, little has been achieved in improving clinical efficacy towards it. Factors such as chemokines play important role in shaping the tumor microenvironment which in turn plays a significant role in deciding course of tumor progression. In this study, we investigated the role of chemokine IL-8 in glioblastoma progression with particular emphasis on immunomodulation, cellular proliferation, invasion and vascular mimicry...
August 8, 2018: Journal of Biomedical Science
https://www.readbyqxmd.com/read/30081400/risk-factors-linked-to-central-catheter-associated-thrombosis-in-critically-ill-infants-in-the-neonatal-intensive-care-unit
#19
Isabella Lambert, Sergey Tarima, Michael Uhing, Susan S Cohen
OBJECTIVE:  Our study identified risk factors for the development of clinically identifiable catheter-associated thrombosis (CT). STUDY DESIGN:  We performed a retrospective cohort study of neonates in whom a central catheter was present. A total of 1,475 catheters were identified in 766 patients during a 36-month study period. The odds ratio (OR) of thrombi formation in catheterized neonates was modeled using simple (single predictor) and multiple (multiple predictors) logistic regressions as well as simple and multiple Cox's proportional hazard models...
August 6, 2018: American Journal of Perinatology
https://www.readbyqxmd.com/read/30079284/comparison-of-short-vs-long-axis-technique-for-ultrasound-guided-peripheral-line-placement-a-systematic-review-and-meta-analysis
#20
REVIEW
Michael Gottlieb, Dallas Holladay, Gary D Peksa
Ultrasound-guided peripheral intravenous line (PIV) placement is associated with increased success rates, decreased time to cannulation, and fewer skin punctures than traditional, landmark-based techniques. However, it is unclear which technique is best. This review compares the short-axis (SA) and long-axis (LA) techniques for PIV placement. PubMed, Embase, Scopus, the Cochrane Database of Systematic Reviews, the Cochrane Central Register of Controlled Trials, and bibliographies of selected articles were assessed for prospective trials evaluating the first pass success rate of SA vs LA ultrasound-guided PIV placement...
May 31, 2018: Curēus
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