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https://www.readbyqxmd.com/read/30550847/a-role-for-wnt-%C3%AE-catenin-signalling-in-suppressing-bacillus-calmette-guerin-induced-macrophage-autophagy
#1
Xiaoling Wu, Jiamei Zhang, Chenjie Ma, Wu Li, Jin Zeng, Yujiong Wang, Guangcun Deng
Mycobacterium tuberculosis (Mtb)-induced autophagy of alveolar macrophages has been confirmed to play a central role in the pathogenesis of tuberculosis. Growing evidence indicates that excessive or uncontrolled autophagic activity, which results in type II programmed cell death, can be regulated by many factors, including Wnt/β-catenin signalling. Wnt/β-catenin signalling has been demonstrated to be involved in multiple diseases through the regulation of autophagy; however, its exact role in regulating autophagy induced by Mtb remains unclear...
December 11, 2018: Microbial Pathogenesis
https://www.readbyqxmd.com/read/30549365/quantitative-multi-locus-metabarcoding-and-waggle-dance-interpretation-reveal-honey-bee-spring-foraging-patterns-in-midwest-agroecosystems
#2
Rodney T Richardson, Hailey R Curtis, Emma G Matcham, Chia Hua Lin, Sreelakshmi Suresh, Douglas B Sponsler, Luke E Hearon, Reed M Johnson
We explored the pollen foraging behavior of honey bee colonies situated in the corn and soybean dominated agroecosystems of central Ohio over a month-long period using both pollen metabarcoding and waggle dance inference of spatial foraging patterns. For molecular pollen analysis we developed simple and cost-effective laboratory and bioinformatics methods. Targeting four plant barcode loci (ITS2, rbcL, trnL and trnH), we implemented metabarcoding library preparation and dual-indexing protocols designed to minimize amplification biases and index mis-tagging events...
December 14, 2018: Molecular Ecology
https://www.readbyqxmd.com/read/30547197/predictors-of-thrombosis-in-testicular-cancer-during-platinum-based-chemotherapy
#3
Pia Paffenholz, Katharina Grein, Isabel Heidegger, Tim Nestler, Markus Grabbert, Johannes Salem, Martin Hellmich, David Pfister, Axel Heidenreich
PURPOSE: To identify potential risk factors for the development of venous thromboembolic events in testicular cancer patients receiving platinum-based chemotherapy. METHODS: We performed a retrospective analysis including 255 patients with testicular germ cell tumors who received platinum-based chemotherapy from 2003 to 2018 as a multi-center observational cohort study. Patient and tumor characteristics of patients with and without a thromboembolic event were analyzed...
December 13, 2018: World Journal of Urology
https://www.readbyqxmd.com/read/30544507/-drosophila-as-a-model-to-study-brain-innate-immunity-in-health-and-disease
#4
REVIEW
Shu Hui Lye, Stanislava Chtarbanova
Innate immunity is the first line of defense against invading pathogens and plays an essential role in defending the brain against infection, injury, and disease. It is currently well recognized that central nervous system (CNS) infections can result in long-lasting neurological sequelae and that innate immune and inflammatory reactions are highly implicated in the pathogenesis of neurodegeneration. Due to the conservation of the mechanisms that govern neural development and innate immune activation from flies to mammals, the lack of a classical adaptive immune system and the availability of numerous genetic and genomic tools, the fruit fly Drosophila melanogaster presents opportunities to investigate the cellular and molecular mechanisms associated with immune function in brain tissue and how they relate to infection, injury and neurodegenerative diseases...
December 7, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/30543927/a-large-screen-for-paraneoplastic-neurological-autoantibodies-diagnosis-and-predictive-values
#5
Lior Seluk, Alisa Taliansky, Hagith Yonath, Boris Gilburd, Howard Amital, Yehuda Shoenfeld, Shaye Kivity
BACKGROUND: Paraneoplastic neurological syndromes (PNS) are a group of syndromes that affect the central and peripheral neuromuscular system in association with cancer. Specific antibodies may assist in the diagnosis of PNS. The antibodies tested can be classified into those directed against intracellular neuronal proteins ("well characterized" PNS: Hu, Yo, RI, CV2, amphiphysin, Ma1, Ma2) and those directed against neural surface antigens (autoimmune encephalitis syndromes: NMDA, AMPA, LGI1, CASPR2, GABAR)...
December 10, 2018: Clinical Immunology: the Official Journal of the Clinical Immunology Society
https://www.readbyqxmd.com/read/30543538/perioperative-clinical-considerations-in-a-patient-with-carotid-agenesis-a-case-report
#6
Milly T Rambhia, Eric Kamenetsky
An 86-year-old female with previously diagnosed congenitally absent right internal carotid artery presented for total shoulder arthroplasty. Bedside ultrasonography confirmed the anomaly and identified several arterial collateral vessels. No aberrant vessels were seen traversing the brachial plexus. The patient received brachial plexus blockade and general anesthesia for the procedure. Carotid agenesis is associated with increased prevalence of intracranial aneurysm. Patients are often asymptomatic due to adequate blood supply from collateral vessels...
December 11, 2018: A&A practice
https://www.readbyqxmd.com/read/30538527/antineutrophil-cytoplasmic-antibody-associated-vasculitis-update-on-molecular-pathogenesis-diagnosis-and-treatment
#7
REVIEW
Farid Arman, Marina Barsoum, Umut Selamet, Hania Shakeri, Olivia Wassef, Mira Mikhail, Anjay Rastogi, Ramy M Hanna
Circulating antineutrophil cytoplasmic antibodies (ANCAs) are the central pathogenic mechanism for a group of systemic and renal syndromes called the ANCA-associated vasculitis (AAV). The nomenclature has changed from eponymous labeling to granulomatosis with polyangiitis, eosinophilic granulomatosis with polyangiitis, and microscopic polyangiitis. These syndromes predominantly affect the pulmonary and renal systems. We also review the molecular pathology behind ANCAs and associated antigens and infections...
2018: International Journal of Nephrology and Renovascular Disease
https://www.readbyqxmd.com/read/30537994/microrna-153-3p-enhances-cell-radiosensitivity-by-targeting-bcl2-in-human-glioma
#8
Deyu Sun, Yi Mu, Haozhe Piao
BACKGROUND: Glioma is the most prevalent malignant tumor in human central nervous systems. Recently, the development of resistance to radiotherapy in glioma patients markedly vitiates the therapy outcome. MiR-153-3p has been reported to be closely correlated with tumor progression, but its effect and molecular mechanism underlying radioresistance remains unclear in glioma. METHODS: The expression of miR-153-3p was determined in radioresistant glioma clinical specimens as well as glioma cell lines exposed to irradiation (IR) using quantitative real-time PCR...
December 11, 2018: Biological Research
https://www.readbyqxmd.com/read/30535802/-r-gemox-chemotherapy-for-unfit-patients-with-refractory-or-recurrent-primary-central-nervous-system-lymphoma-a-loc-study
#9
A Collignon, C Houillier, G Ahle, O Chinot, S Choquet, A Schmitt, P Agape, C Soussain, K Hoang-Xuan, Emeline Tabouret
Recurrent primary central nervous system lymphomas (PCNSL) have a very poor prognosis. For young and fit patients, intensive chemotherapy followed by autologous stem cell transplantation could be proposed at relapse. In the other cases (unfit or elderly patients), therapeutic options are limited with no consensual regimen. The poly-chemotherapy by (R)-GEMOX is associated with anti-tumor activity in systemic lymphomas and a favorable toxicity profile. Our objective was to evaluate the activity and tolerance of (R)-GEMOX in PCNSL patients enrolled in the French nation-wide LOC cohort...
December 7, 2018: Annals of Hematology
https://www.readbyqxmd.com/read/30533330/the-impact-of-automated-electronic-surveillance-of-electronic-medical-records-on-pediatric-inpatient-care
#10
Jais Emmanuel, Adalberto Torres
Purpose To assess the impact of the automated surveillance of the electronic medical record process on clinical interventions among hospitalized children at a tertiary care pediatric center. Methods A retrospective chart review of the alerts triggered for central line-associated blood stream infections (CLABSIs), catheter-associated urinary tract infections (CAUTIs), neonatal sepsis, or clinical deterioration through elevated pediatric early warning scores (PEWS) by automated electronic surveillance of the hospital electronic medical record (EMR) over a five-month period among hospitalized children...
October 1, 2018: Curēus
https://www.readbyqxmd.com/read/30529211/promising-neuroprotective-effects-of-%C3%AE-caryophyllene-against-lps-induced-oligodendrocyte-toxicity-a-mechanistic-study
#11
Vahid Reza Askari, Reza Shafiee-Nick
Myelin loss subsequent to oligodendrocyte death has been reported in a variety of myelin-associated disorders such as multiple sclerosis (MS). Lipopolysaccharide (LPS) has been shown to elicit cellular responses in the central nervous system (CNS) and trigger immune infiltrates and glial cells to release a variety of inflammatory cytokines and mediators. LPS-induced oligodendrocytes toxicity may be chosen as an efficient model to evaluate the role of oligodendrocytes in neuroprotective activities of compounds...
December 5, 2018: Biochemical Pharmacology
https://www.readbyqxmd.com/read/30527768/compliance-with-evidence-based-guidelines-for-the-prevention-of-central-line-associated-bloodstream-infections-in-a-belgian-home-care-setting-an-observational-study
#12
Ester Steffens, Isabel Spriet, Johan Van Eldere, Annette Schuermans
This study assessed the compliance of Belgian home care nurses with good practice recommendations to prevent central line-associated bloodstream infections. The compliance to 3 care bundles was 0% (0 out of 7), 13.3% (2 out of 15), and 22.2% (2 out of 9), respectively. This finding is important given the increasing number of home care patients with an intravascular catheter and underscores the need for quality improvement strategies to prevent central line-associated bloodstream infections in home care.
December 6, 2018: American Journal of Infection Control
https://www.readbyqxmd.com/read/30527053/cligosiban-a-novel-brain-penetrant-selective-oxytocin-receptor-antagonist-inhibits-ejaculatory-physiology-in-rodents
#13
Chris Wayman, Rachel Russell, Kim Tang, Laura Weibly, Samantha Gaboardi, Lucy Fisher, Kelly Allers, Margaret Jackson, Tony Hawcock, Nicola Robinson, Lesley Wilson, Julie Gupta, James Casey, Karl R Gibson
INTRODUCTION: Few treatments are available for men with premature ejaculation (PE); oxytocin (OT) receptor antagonism in the central nervous system (CNS) is a potential new approach. AIM: To determine if cligosiban selectively inhibits human OT receptors, penetrates the CNS, shows pharmacology in the CNS, and effects ejaculatory physiology in pre-clinical systems. METHODS: Experiments complied with United Kingdom legislation and were subject to local ethical review...
December 2018: Journal of Sexual Medicine
https://www.readbyqxmd.com/read/30526719/centers-for-medicare-and-medicaid-services-hospital-acquired-conditions-policy-for-central-line-associated-bloodstream-infection-clabsi-and-catheter-associated-urinary-tract-infection-cauti-shows-minimal-impact-on-hospital-reimbursement-corrigendum
#14
https://www.readbyqxmd.com/read/30522838/kamishibai-cards-to-sustain-evidence-based-practices-to-reduce-health-care-associated-infections
#15
Grace Shea, Windy Smith, Kirsten Koffarnus, Mary Jo Knobloch, Nasia Safdar
BACKGROUND: Sustaining healthcare-associated infection (HAI) prevention practices is complex. We examined the use of Kamishibai Cards (K Cards) as a tool to encourage compliance interactions between leaders and staff. METHODS: We explored one unit of a children's hospital to assess acceptability of K Cards. Interactions were recorded (n = 14), and interviews were conducted (n = 22). We used the Health Belief Model (HBM) for analyses. Central line utilization, bundle compliance and rates of HAIs were also examined...
December 3, 2018: American Journal of Infection Control
https://www.readbyqxmd.com/read/30522104/association-of-central-venous-oxygen-saturation-variability-and-mortality-in-hemodialysis-patients
#16
Hanjie Zhang, Israel Campos, Lili Chan, Anna Meyring-Wösten, Leticia M Tapia Silva, Lemuel Rivera Fuentes, Priscila Preciado, Stephan Thijssen, Jeroen P Kooman, Frank M van der Sande, Peter Kotanko
BACKGROUND: Central venous oxygen saturation (ScvO2) is correlated with cardiac output. In most patients, ScvO2 declines during hemodialysis (HD) due to factors such as reduced preload, myocardial stunning, and intermittent arrhythmias. Previous research has shown that low ScvO2 is associated with higher mortality in chronic HD patients. In this research, we tested the hypothesis that ScvO2 variability is associated with all-cause mortality. METHODS: We conducted a retrospective study in 232 chronic HD patients with central venous catheter as vascular access...
December 6, 2018: Blood Purification
https://www.readbyqxmd.com/read/30521864/a-network-approach-to-quantifying-radiotherapy-effect-on-cancer-radiosensitive-gene-group-centrality
#17
Yu-Xiang Yao, Zhi-Tong Bing, Liang Huang, Zi-Gang Huang, Ying-Cheng Lai
Radiotherapy plays a vital role in cancer treatment, for which accurate prognosis is important for guiding sequential treatment and improving the curative effect for patients. An issue of great significance in radiotherapy is to assess tumor radiosensitivity for devising the optimal treatment strategy. Previous studies focused on gene expression in cells closely associated with radiosensitivity, but factors such as the response of a cancer patient to irradiation and the patient survival time are largely ignored...
December 3, 2018: Journal of Theoretical Biology
https://www.readbyqxmd.com/read/30521571/evaluation-of-the-prognostic-value-of-all-four-her-family-receptors-in-patients-with-metastatic-breast-cancer-treated-with-trastuzumab-a-hellenic-cooperative-oncology-group-hecog-study
#18
Angelos Koutras, Georgios Lazaridis, Georgia-Angeliki Koliou, George Kouvatseas, Christos Christodoulou, Dimitrios Pectasides, Vassiliki Kotoula, Anna Batistatou, Mattheos Bobos, Eleftheria Tsolaki, Kyriaki Papadopoulou, George Pentheroudakis, Pavlos Papakostas, Stavroula Pervana, Kalliopi Petraki, Sofia Chrisafi, Evangelia Razis, Amanda Psyrri, Dimitrios Bafaloukos, Konstantine T Kalogeras, Haralambos P Kalofonos, George Fountzilas
In the current study, we performed a complete analysis, with four different methods, of all four HER family receptors, in a series of patients with metastatic breast cancer treated with trastuzumab-based regimens and evaluated their prognostic value. Formalin-fixed paraffin-embedded tumor tissue samples were collected from 227 patients, considered to be HER2-positive when assessed at the local laboratories. We evaluated gene amplification, copy number variations (CNVs), mRNA and protein expression of all four HER family members...
2018: PloS One
https://www.readbyqxmd.com/read/30516122/cefazolin-as-surgical-antimicrobial-prophylaxis-in-hysterectomy-a-systematic-review-and-meta-analysis-of-randomized-controlled-trials
#19
Aurora Pop-Vicas, Stephen Johnson, Nasia Safdar
OBJECTIVE: Current practice guidelines recommend cefazolin, cefoxitin, cefotetan, or ampicillin-sulbactam as first-line antibiotic prophylaxis in hysterectomy. We undertook this systematic review and meta-analysis of randomized controlled trials (RCTs) to determine whether cefazolin, with limited antianaerobic spectrum, is as effective in preventing surgical site-infection (SSI) as the other first-choice antimicrobials that have more extensive antianaerobic activity. METHODS: We searched PubMed, Scopus, Web of Science, Cochrane Central, and EMBASE for relevant randomized controlled trials (RCT) in any language up to January 23, 2018...
December 5, 2018: Infection Control and Hospital Epidemiology
https://www.readbyqxmd.com/read/30514230/egf-egfr-upregulates-and-cooperates-with-netrin-4-to-protect-glioblastoma-cells-from-dna-damage-induced-senescence
#20
Li Li, Yulun Huang, Yuge Gao, Tengfei Shi, Yunyun Xu, Huini Li, Marko Hyytiäinen, Jorma Keski-Oja, Qiuying Jiang, Yizhou Hu, Zhimin Du
BACKGROUND: Glioblastoma multiforme (GBM) is the most malignant central nervous system tumor. Alkylating agent, temozolomide (TMZ), is currently the first-line chemotherapeutic agent for GBM. However, the sensitivity of GBM cells to TMZ is affected by many factors. And, several clinic trials, including co-administration of TMZ with other drugs, have failed in successful treatment of GBM. We have previously reported that Netrin-4 (NTN4), a laminin-like axon guidance protein, plays a protective role in GBM cell senescence upon TMZ-triggered DNA damage...
December 4, 2018: BMC Cancer
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