Luis Vence, Samantha L Bucktrout, Irina Fernandez Curbelo, Jorge Blando, Bevin M Smith, Ashley E Mahne, John C Lin, Terrence Park, Edward Pascua, Tao Sai, Javier Chaparro-Riggers, Sumit K Subudhi, Jorge B Scutti, Maria G Higa, Hao Zhao, Shalini S Yadav, Anirban Maitra, Ignacio I Wistuba, James P Allison, Padmanee Sharma
PURPOSE: Determine the differential effect of a FcγR-binding, mIgG2a anti-GITR antibody in mouse tumor models, and characterize the tumor microenvironment for the frequency of GITR expression in T-cell subsets from seven different human solid tumors. Experimental Design: For mouse experiments, wild-type C57BL/6 mice were subcutaneously injected with MC38 cells or B16 cells, and BALB/c mice were injected with CT26 cells. Mice were treated with the anti-mouse GITR agonist antibody 21B6, and tumor burden and survival were monitored...
November 1, 2019: Clinical Cancer Research