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gene environment interaction

Eva Asselmann, Johannes Hertel, Carsten-Oliver Schmidt, Georg Homuth, Matthias Nauck, Christiane A Pané-Farré, Beesdo-Baum Katja, Hans-Jörgen Grabe
BACKGROUND: It remains unresolved whether childhood adversities interact with genetic variation in regulator of G-protein signaling 2 (RGS2) rs4606 in predicting various anxiety and depressive disorders and whether diagnostic specificity exists in these interactions. METHODS: The genotype of RGS2 rs4606 was determined for N = 2,263 adults with European ancestry from the Study of Health in Pomerania. Lifetime anxiety and depressive disorders according to the Diagnostic and Statistical Manual of Mental Disorders, fourth edition, were assessed with the Munich Composite International Diagnostic Interview (DIA-X/M-CIDI)...
August 14, 2018: Depression and Anxiety
Bruno Sauce, Sophie Bendrath, Margalit Herzfeld, Dan Siegel, Conner Style, Sayeeda Rab, Jonathan Korabelnikov, Louis D Matzel
General cognitive ability can be highly heritable in some species, but at the same time, is very malleable. This apparent paradox could potentially be explained by gene-environment interactions and correlations that remain hidden due to experimental limitations on human research and blind spots in animal research. Here, we shed light on this issue by combining the design of a sibling study with an environmental intervention administered to laboratory mice. The analysis included 58 litters of four full-sibling genetically heterogeneous CD-1 male mice, for a total of 232 mice...
September 26, 2018: Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
Florin Mircea Iliescu, George Chaplin, Niraj Rai, Guy S Jacobs, Chandana Basu Mallick, Anshuman Mishra, Kumarasamy Thangaraj, Nina G Jablonski
OBJECTIVES: Skin color is a highly visible and variable trait across human populations. It is not yet clear how evolutionary forces interact to generate phenotypic diversity. Here, we sought to unravel through an integrative framework the role played by three factors-demography and migration, sexual selection, and natural selection-in driving skin color diversity in India. METHODS: Skin reflectance data were collected from 10 diverse socio-cultural populations along the latitudinal expanse of India, including both sexes...
August 12, 2018: American Journal of Human Biology: the Official Journal of the Human Biology Council
Fang Lin, Yan Jiang, Jian Li, Tingting Yan, Liumin Fan, Jian-Sheng Liang, Z Jeffrey Chen, Dongqing Xu, Xing Wang Deng
Plants have evolved a delicate molecular system to fine-tune their growth and development in response to dynamically changing light environments. In this study, we found that BBX28, a B-box domain protein, negatively regulates photomorphogenic development in a dose-dependent manner in Arabidopsis thaliana. BBX28 interferes with the binding of transcription factor HY5 to the promoters of its target genes through physical interactions, thereby repressing its activity and negatively affecting HY5-regulated gene expression...
August 10, 2018: Plant Cell
Emily E Virgin, Kimberly A Rosvall
Immune function varies with an animal's endocrine physiology and energy reserves, as well as its abiotic and biotic environment. This context-dependency is thought to relate to adaptive trade-off resolution that varies from one context to the next; however, it is less clear how state- and environmentally-dependent differences in endocrine-immune signaling relate to survival in natural populations. We begin to address this question in a prospective study on a free-living passerine bird, the tree swallow (Tachycineta bicolor), by capitalizing upon naturally-occurring variation in ectoparasitism in 12-day old chicks...
August 9, 2018: General and Comparative Endocrinology
Julia Manetsberger, Abhinaba Ghosh, Elizabeth A H Hall, Graham Christie
The exosporium of Bacillus megaterium QM B1551 spores is morphologically distinct to exosporia observed in spores of many other species. Previous work has demonstrated that unidentified genes encoded on one of the large indigenous plasmids are required for the assembly of the Bacillus megaterium exosporium. Here we provide evidence that pBM600-encoded orthologues of the Bacillus subtilis CotW and CotX proteins, which form the crust layer in spores of that species, are structural components of the Bacillus megaterium QM B1551 spore exosporium...
August 10, 2018: Applied and Environmental Microbiology
Chiaki Hori, Jill Gaskell, Dan Cullen, Grzegorz Sabat, Philip E Stewart, Kathleen Lail, Yi Peng, Kerrie Barry, Igor V Grigoriev, Annegret Kohler, Laure Fauchery, Francis Martin, Carolyn A Zeiner, Jennifer M Bhatnagar
Fungi play a key role cycling nutrients in forest ecosystems but the mechanisms remain uncertain. To clarify the enzymatic processes involved in wood decomposition, metatranscriptomics and metaproteomics of extensively decayed lodgepole pine were examined by RNAseq and LC-MS/MS, respectively. Following de novo metatranscriptome assembly, 52,011 contigs were searched for functional domains and homology to database entries. Contigs similar to to basidiomycete transcripts dominated and many of these were most closely related to ligninolytic white rot fungi or cellulolytic brown rot fungi...
August 10, 2018: Applied and Environmental Microbiology
Wenshan Fu, Zhuowang Chen, Yansen Bai, Xiulong Wu, Guyanan Li, Weilin Chen, Gege Wang, Suhan Wang, Xiaoliang Li, Meian He, Xiaomin Zhang, Tangchun Wu, Huan Guo
Telomere length (TL) is an index of cellular aging and can predict the incidences of many age-related diseases. Change of TL might be affected by environmental pollution and individual's genetic background. In this cohort study, we aimed to evaluate the associations between polycyclic aromatic hydrocarbons (PAHs) exposure and longitudinal TL shortening, and investigate whether genetic variations in TERT-CLPTM1L can modify these associations. We measured the baseline concentrations of twelve urinary PAH metabolites and genotyped six variants at TERT-CLPTM1L among 1243 coke-oven workers...
August 7, 2018: Environmental Pollution
Zubaida Daudzai, Chairat Treesubsuntorn, Paitip Thiravetyan
Air pollutants especially polyaromatic hydrocarbons pose countless threats to the environment. This issue demands for an effective phytoremediation technology. In this study we report the beneficial interactions of Clitoria ternatea and its plant growth promoting endophytic bacteria Bacillus cereus ERBP by inoculating it for the remediation of 5 ppm airborne ethylbenzene (EB). The percentage efficiency for ethylbenzene removal among B. cereus ERBP inoculated and non-inoculated sterile and natural C. ternatea has also been determined...
August 7, 2018: Ecotoxicology and Environmental Safety
Conghua Ji, Shan Liu, Kan Zhu, Hongbin Luo, Qiushuang Li, Ying Zhang, Sijia Huang, Qing Chen, Yi Cao
BACKGROUND: Published studies have reported conflicting and heterogeneous results regarding the association between human leukocyte antigen (HLA)-DRB1 polymorphisms and alopecia areata (AA). This study aimed to review and quantitatively analyze the association between HLA-DRB1 polymorphisms and AA. METHODS: In this study, all relevant publications were searched through December 2016. Odds ratios (ORs) and confidence intervals (CIs) for comparisons between case and control groups were calculated...
August 2018: Medicine (Baltimore)
Andrea Bulbena-Cabre, Anahita Bassir Nia, M Mercedes Perez-Rodriguez
PURPOSE OF REVIEW: We review the existing literature on gene-environment interactions (G×E) and epigenetic changes primarily in borderline personality disorder (BPD) but also in antisocial, schizotypal, and avoidant personality disorders. RECENT FINDINGS: Research supports that susceptibility genes to BPD or its underlying traits may be expressed under certain environmental conditions such as physical or childhood sexual abuse. Epigenetic modifications of neurodevelopment- and stress-related genes are suggested to underlie the relationship between early life adversary and borderline personality disorder...
August 9, 2018: Current Psychiatry Reports
Ziran Xu, Xia He, Xu Shi, Yuhan Xia, Xiaomei Liu, Haitao Wu, Pengdong Li, Hongyu Zhang, Weisi Yin, Xiubo Du, Lisha Li, Yulin Li
BACKGROUND: Differentiation of human induced pluripotent stem cells (hiPSCs) into hepatocytes has important clinical significance in providing a new stem cell source for cell therapy of terminal liver disease. The differential gene expression analysis of hiPSCs, induced hepatocyte-like cells (HLCs), and primary human hepatocytes (PHHs) provides valuable information for optimization of an induction scheme and exploration of differentiation mechanisms. METHODS: Human hair follicle-derived iPSCs (hHF-iPSCs) were induced in vitro by mimicking the environment of a developing liver for 19 days...
August 9, 2018: Stem Cell Research & Therapy
Divya Sharma, Apoorv Tiwari, Salej Sood, Gautam Jamra, N K Singh, Prabina Kumar Meher, Anil Kumar
Finger millet (Eleusine coracana L.) is an important dry-land cereal in Asia and Africa because of its ability to provide assured harvest under extreme dry conditions and excellent nutritional properties. However, the genetic improvement of the crop is lacking in the absence of suitable genomic resources for reliable genotype-phenotype associations. Keeping this in view, a diverse global finger millet germplasm collection of 113 accessions was evaluated for 14 agro-morphological characters in two environments viz...
2018: PloS One
Brandon J Coombes, Joanna M Biernacka
Testing for gene-environment (GE) interactions in a gene-set defined by a biological pathway can help us understand the interplay between genes and environments and provide insight into disease etiology. A self-contained gene-set analysis can be performed by combining gene-level p-values using approaches such as the Gamma Method. In a gene-set analysis of genetic main effects, permutation approaches are commonly used to avoid inflated probability of a type 1 error caused by correlation of genes within the same pathway...
August 8, 2018: European Journal of Human Genetics: EJHG
James Rapkin, Kim Jensen, Clarissa M House, Alastair J Wilson, John Hunt
Changes in feeding behaviour, especially the overconsumption of calories, has led to a rise in the rates of obesity, diabetes, and other associated disorders in humans and a range of animals inhabiting human-influenced environments. However, understanding the relative contribution of genes, the nutritional environment, and their interaction to dietary intake and lipid deposition in the sexes still remains a major challenge. By combining nutritional geometry with quantitative genetics, we determined the effect of genes, the nutritional environment, and their interaction on the total nutritional preference (TP), total diet eaten (TE), and lipid mass (LM) of male and female black field crickets (Teleogryllus commodus) fed one of four diet pairs (DPs) differing in the ratio of protein to carbohydrate and total nutritional content...
August 8, 2018: Heredity
Cristina Giuliani, Marco Sazzini, Chiara Pirazzini, Maria Giulia Bacalini, Elena Marasco, Guido Alberto Gnecchi Ruscone, Fang Fang, Stefania Sarno, Davide Gentilini, Anna Maria Di Blasio, Paolina Crocco, Giuseppe Passarino, Daniela Mari, Daniela Monti, Benedetta Nacmias, Sandro Sorbi, Carlo Salvarani, Mariagrazia Catanoso, Davide Pettener, Donata Luiselli, Svetlana Ukraintseva, Anatoliy Yashin, Claudio Franceschi, Paolo Garagnani
The study of the genetics of longevity has been mainly addressed by GWASs that considered subjects from different populations to reach higher statistical power. The "price to pay" is that population-specific evolutionary histories and trade-offs were neglected in the investigation of gene-environment interactions. We propose a new "diachronic" approach that considers processes occurred at both evolutionary and lifespan timescales. We focused on a well-characterized population in terms of evolutionary history ( i...
August 8, 2018: Aging
Tuuli Ahlstrand, Annamari Torittu, Heli Elovaara, Hannamari Välimaa, Marja T Pöllänen, Sergo Kasvandik, Martin Högbom, Riikka Ihalin
Naturally competent bacteria acquire DNA from their surroundings to survive in nutrient-poor environments and incorporate DNA into their genomes as new genes for improved survival. The secretin HofQ from the oral pathogen Aggregatibacter actinomycetemcomitans has been associated with DNA uptake. Cytokine sequestering is a potential virulence mechanism in various bacteria and may modulate both host defense and bacterial physiology. The objective of this study was to elucidate a possible connection between natural competence and cytokine uptake in A...
2018: Virulence
Masaki Nishioka, Miki Bundo, Kazuya Iwamoto, Tadafumi Kato
Psychiatric disorders such as schizophrenia and bipolar disorder are caused by complex gene-environment interactions. While recent advances in genomic technologies have enabled the identification of several risk variants for psychiatric conditions, including single-nucleotide variants and copy-number variations, these factors can explain only a portion of the liability to these disorders. Although non-inherited factors had previously been attributed to environmental causes, recent genomic analyses have demonstrated that de novo mutations are among the main non-inherited risk factors for several psychiatric conditions...
August 7, 2018: Molecular Psychiatry
Quan Luo, Jingxin Zeng, Wei Li, Ling Lin, Xin Zhou, Xin Tian, Weiyu Liu, Lidan Zhang, Xibao Zhang
To investigate the association of MTHFR gene polymorphism and additional gene-gene interaction with psoriasis risk. GMDR model was used to screen the best gene-smoking and gene-drinking interaction combinations. Logistic regression was performed to investigate association between two SNPs and psoriasis. For psoriasis patient-control haplotype analyses, the SHEsis online haplotype analysis software ( ) was employed. We found that carriers of homozygous mutant of rs1801133 polymorphism and heterozygous of rs1801131 are associated with increased psoriasis risk than those with wild-type homozygotes, OR (95%CI) were 2...
August 6, 2018: Immunologic Research
Jay Belsky, Irina Pokhvisneva, Anu Sathyan Sathyapalan Rema, Birit F P Broekman, Michael Pluess, Kieran J O'Donnell, Michael J Meaney, Patrícia P Silveira
A recent article in this journal reported a number of gene × environment interactions involving a serotonin transporter-gene network polygenic score and a composite index of prenatal adversity predicting several problem behavior outcomes at 48 months (e.g., anxious/depressed, pervasive developmental problems) and at 60 months (e.g., withdrawal, internalizing problems), yet did not illuminate the nature or form these genetic × environment interactions took. Here we report results of six additional analyses to evaluate whether these interactions reflected diathesis-stress or differential-susceptibility related processes...
August 7, 2018: Development and Psychopathology
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