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Diastolic Dysfunction Or HFpEF

Gaetano Ruocco, Isabella Evangelista, Beatrice Franci, Barbara Lucani, Simona Martini, Ranuccio Nuti, Alberto Palazzuoli
BACKGROUND: Diabetes is a common disease in heart failure and its prevalence ranges from 10 to 30%. ST-2 is a novel biomarker of myocardial fibrosis and remodelling in heart failure and may be involved in the inflammatory process of diabetes mellitus. In this study, we sought: to evaluate levels of ST-2 and B-type natriuretic peptide (BNP) in groups with acute heart failure with and without diabetes; to analyse the prognostic impact of ST-2 over a 6-month follow-up period. METHODS: We performed an echocardiographic examination and measured ST-2 and BNP within 24 h of hospital admission...
December 11, 2018: Journal of Cardiovascular Medicine
Marie Aymami, Myriam Amsallem, Jackson Adams, Karim Sallam, Kegan Moneghetti, Matthew Wheeler, William Hiesinger, Jeffrey Teuteberg, Dana Weisshaar, Jean-Philippe Verhoye, Y Joseph Woo, Richard Ha, François Haddad, Dipanjan Banerjee
BACKGROUND: Right heart failure (RHF) after left ventricular assist device (LVAD) implantation is associated with high morbidity and mortality. Existing risk scores include semiquantitative evaluation of right ventricular (RV) dysfunction. This study aimed to determine whether quantitative evaluation of both RV size and function improve risk stratification for RHF after LVAD implantation beyond validated scores. METHODS AND RESULTS: From 2009 to 2015, 158 patients who underwent implantation of continuous-flow devices who had complete echocardiographic and hemodynamic data were included...
December 2018: Journal of Cardiac Failure
Bożena Targońska-Stępniak, Małgorzata Biskup, Wojciech Biskup, Maria Majdan
INTRODUCTION/OBJECTIVES: Patients with rheumatoid arthritis (RA) are at increased risk for congestive heart failure (CHF) and left ventricular diastolic dysfunction (LVDD), as compared to the general population. High disease activity is to be associated with higher incidence of cardiovascular disease (CVD), CHF, and mortality in RA patients. LVDD is not anticipated in RA patients without CVD symptoms and may be underdiagnosed especially in those with low disease activity. METHOD: The study group consisted of 70 RA patients (54 women, 16 men) with no CVD and 33 healthy controls, of comparable age...
December 12, 2018: Clinical Rheumatology
Shunta Hori, Tatsuki Miyamoto, Keiichi Sakamoto, Takuto Shimizu, Kazuki Ichikawa, Yosuke Morizawa, Daisuke Gotoh, Yasushi Nakai, Makito Miyake, Tatsuo Yoneda, Nobumichi Tanaka, Katsunori Yoshida, Kiyohide Fujimoto
Background: Transplant renal vein thrombosis (TRVT) is a severe vascular complication and is caused by various factors, including recipient factors, donor factors, immunosuppression regimens, and surgical techniques. Despite adequate interventions, including thrombolytic therapy or surgical thrombectomy, successful salvage of the allograft is often difficult. We observed a case of TRVT induced by compression of the renal vein immediately after intraoperative abdominal closure. Case presentation: A 41-year-old male underwent ABO-compatible living kidney transplantation...
2018: International Journal of Nephrology and Renovascular Disease
Geoffrey J Culshaw, Hannah M Costello, David Binnie, Kevin R Stewart, Alicja Czopek, Neeraj Dhaun, Patrick W F Hadoke, David J Webb, Matthew A Bailey
KEY POINTS SUMMARY: Type 1 diabetes mellitus increases cardiovascular risk: hypertension amplifies this risk. Pressure natriuresis regulates long-term blood pressure. We induced type 1 diabetes in rats by streptozotocin injection and after three weeks demonstrated a substantial impairment of pressure natriuresis: acute increases in blood pressure did not increase renal medullary blood flow, and tubular sodium reabsorption was not downregulated. Proximal tubule sodium reabsorption, measured by lithium clearance, was unaffected...
December 7, 2018: Journal of Physiology
Zhen-Wei Ge, Bao-Cai Wang, Jun-Long Hu, Jun-Jie Sun, Sheng Wang, Xian-Jie Chen, Shu-Ping Meng, Lin Liu, Zhao-Yun Cheng
Cardiac rupture and ventricular remodeling are recognized as the severe complications and major risk factors of acute myocardial infarction (AMI). This study aims to evaluate the regulatory roles of interleukin-1 receptor-associated kinase 3 (IRAK3) and nuclear factor-κB (NF-κB) signaling pathway in cardiac rupture and ventricular remodeling. Microarray analysis was performed to screen AMI-related differentially expressed genes and IRAK3 was identified. The models of AMI were established in male C57BL/6 mice to investigate the functional role of IRAK3...
December 7, 2018: Journal of Cellular Physiology
Stojan Peric, Bogdan Bjelica, Ksenija Aleksic, Masa Kovacevic, Edita Cvitan, Gorana Mandic Stojmenovic, Vidosava Rakocevic Stojanovic
Myotonic dystrophy type 2 (DM2) is a slowly progressive, autosomal-dominant disease. This is a multisystemic disorder that affects the heart, which is one of the main causes of morbidity and mortality in DM2. The aim of the study was to define cardiac impairments in patients with DM2 and its association with sociodemographic and clinical features of patients. This retrospective study comprised 62 adult patients with DM2 hospitalized at the Neurology Clinic, Clinical Center of Serbia from 2013 until 2018, who underwent electrocardiography (ECG) and echocardiography examinations...
December 7, 2018: Acta Neurologica Belgica
Zhuo Xu, Hui-Ping Gu, Yang Gu, Wei Sun, Kun Yu, Xi-Wen Zhang, Xiang-Qing Kong
Objective: To study the coronary microvascular function in older patients with heart failure with preserved ejection fraction (HFpEF) using an invasive pressure-temperature sensor guidewire. Methods: Patients undergoing echocardiography and cardiac catheterization examinations for exertional dyspnea and a positive stress test were retrospectively enrolled from January 2014 to November 2017, and were allocated into the control group or HFpEF group. The HFpEF group was secondary divided into two groups according to the age of 65...
November 2018: Journal of Geriatric Cardiology: JGC
Tsunehisa Yamamoto, Jin Endo, Masaharu Kataoka, Tomohiro Matsuhashi, Yoshinori Katsumata, Kohsuke Shirakawa, Naohiro Yoshida, Sarasa Isobe, Hidenori Moriyama, Shinichi Goto, Kaoru Yamashita, Hiroki Nakanishi, Yuta Shimanaka, Nozomu Kono, Ken Shinmura, Hiroyuki Arai, Keiichi Fukuda, Motoaki Sano
Increase in saturated fatty acid (SFA) content in membrane phospholipids dramatically affects membrane properties and cellular functioning. We sought to determine whether exogenous SFA from the diet directly affects the degree of membrane phospholipid unsaturation in adult hearts and if these changes correlate with contractile dysfunction. Although both SFA-rich high fat diets (HFDs) and monounsaturated FA (MUFA)-rich HFDs cause the same degree of activation of myocardial FA uptake, triglyceride turnover, and mitochondrial FA oxidation and accumulation of toxic lipid intermediates, the former induced more severe diastolic dysfunction than the latter, which was accompanied with a decrease in membrane phospholipid unsaturation, induction of unfolded protein response (UPR), and a decrease in the expression of Sirt1 and stearoyl-CoA desaturase-1 (SCD1), catalyzing the conversion of SFA to MUFA...
2018: PloS One
Rahel Kluttig, Till Friedheim, Christoph Behem, Niko Zach, Rosannis Brown, Michael Graessler, Daniel Reuter, Christian Zöllner, Constantin Trepte
One of the leading causes of morbidity and mortality in patients with heart failure is right ventricular (RV) dysfunction, especially if it is due to pulmonary hypertension. For a better understanding and treatment of this disease, precise hemodynamic monitoring of left and right ventricular parameters is important. For this reason, it is essential to establish experimental pig models of cardiac hemodynamics and measurements for research purpose. This article shows the induction of ARDS by using oleic acid (OA) and consequent right ventricular dysfunction, as well as the instrumentation of the pigs and the data acquisition process that is needed to assess hemodynamic parameters...
November 26, 2018: Journal of Visualized Experiments: JoVE
Wei Li, Fengxiao Zhang, Chenhui Ju, Suying Lv, Kai Huang
BACKGROUND: CD4+ T cells are key players in regulating the inflammatory processes and physiological repair mechanisms engaged after acute myocardial infarction (AMI). Although signaling through the CD27-CD70 co-stimulatory pathway are known to be important in CD4+ T cell activation and proliferation in certain contexts, the role of the CD27-CD70 pathway in AMI remains unclear. METHODS AND RESULTS: A total of 43 control subjects, 42 unstable angina patients, and 90 AMI patients were enrolled in the present study...
December 3, 2018: International Journal of Cardiology
M J DiVincenzo, J D Bonagura, L Rings, T A Burns, R E Cianciolo, R Kohnken
An 8-month-old Hanoverian gelding was presented with a history of cardiac murmurs that were not apparent as a foal nor reported at the time of castration. Major echocardiographic findings included mitral valvular thickening, functional stenosis, and mitral regurgitation of sufficient severity to cause diastolic and systolic cardiac murmurs, left-sided volume overload, and pulmonary hypertension. Due to the hemodynamic severity of the lesion and poor prognosis for future performance and longevity, euthanasia was elected...
December 2018: Journal of Veterinary Cardiology: the Official Journal of the European Society of Veterinary Cardiology
Aymeric Menet, Brigitte Ranque, Ibrahima Bara Diop, Samuel Kingue, Roland N'guetta, Mamadou Diarra, Dapa Diallo, Saliou Diop, Ibrahima Diagne, Ibrahima Sanogo, David Chelo, Guillaume Wamba, Indou Deme-Ly, Blaise Felix Faye, Moussa Seck, Aissata Tolo, Kouakou Boidy, Gustave Koffi, Eli Cochise Abough, Cheick Oumar Diakite, Youssouf Traore, Gaëlle Legueun, Ismael Kamara, Lucile Offredo, Sylvestre Marechaux, Mariana Mirabel, Xavier Jouven
Background: Several studies conducted in America or Europe have described major cardiac remodeling and diastolic dysfunction in patients with sickle cell disease (SCD). We aimed at assessing cardiac involvement in SCD in sub-Saharan Africa where SCD is the most prevalent. Methods: In Cameroon, Mali and Senegal, SCD patients and healthy controls of the CADRE study underwent transthoracic echocardiography if aged ≥10 years. The comparison of clinical and echocardiographic features between patients and controls, and the associations between echocardiographic features and the vascular complications of SCD were assessed...
2018: Frontiers in Medicine
Lamia Al Saikhan, Alun D Hughes, Wing-See Chung, Maryam Alsharqi, Petros Nihoyannopoulos
Aims: Heart failure (HF) with mid-range ejection fraction (HFmrEF) shares similar diagnostic criteria to HF with preserved ejection fraction (HFpEF). Whether left atrial (LA) function differs between HFmrEF and HFpEF is unknown. We, therefore, used 2D-speckle-tracking echocardiography (2D-STE) to assess LA phasic function in patients with HFpEF and HFmrEF. Methods and results: Consecutive outpatients diagnosed with HF according to current European recommendations were prospectively enrolled...
December 4, 2018: European Heart Journal Cardiovascular Imaging
Yalın Tolga Yaylalı, Güzin Fidan-Yaylalı, Beray Can, Hande Şenol, Mehmet Kılınç, Mustafa Yurtdaş
OBJECTIVE: Body mass index (BMI) and waist circumference (WC) as measures of obesity have some limitations. The aim of this study was to evaluate whether one measure could predict the presence of diastolic dysfunction (DD) more accurately than the other measures. METHODS: A total of 91 obese patients without any other risk factors for DD were prospectively enrolled. Echocardiographic examination was performed. DD was defined and categorized according to recent guidelines...
December 2018: Türk Kardiyoloji Derneği Arşivi: Türk Kardiyoloji Derneğinin Yayın Organıdır
Servet Altay
No abstract text is available yet for this article.
December 2018: Türk Kardiyoloji Derneği Arşivi: Türk Kardiyoloji Derneğinin Yayın Organıdır
Rudolf A Werner, Christoph Eissler, Nobuyuki Hayakawa, Paula Arias-Loza, Hiroshi Wakabayashi, Mehrbod S Javadi, Xinyu Chen, Tetsuya Shinaji, Constantin Lapa, Theo Pelzer, Takahiro Higuchi
In diabetic cardiomyopathy, left ventricular (LV) diastolic dysfunction is one of the earliest signs of cardiac involvement prior to the definitive development of heart failure (HF). We aimed to explore the LV diastolic function using electrocardiography (ECG)-gated 18 F-fluorodeoxyglucose positron emission tomography (18 F-FDG PET) imaging beyond the assessment of cardiac glucose utilization in a diabetic rat model. ECG-gated 18 F-FDG PET imaging was performed in a rat model of type 2 diabetes (ZDF fa/fa) and ZL control rats at age of 13 weeks (n = 6, respectively)...
December 4, 2018: Scientific Reports
Anna Pedrinolla, Massimo Venturelli, Emine Kirmizi, Federica Moschetta, Monica Zardini, Doriana Rudi, Elisabetta Bacchi, Federico Schena, Paolo Moghetti, Massimo Lanza
In western countries, aging is often accompanied by obesity and age-related obesity is characterized by vascular dysfunction and a low-grade inflammatory profile. Exercise is a nonpharmacological strategy able to decrease the development and incidence of risk factors for several health-threatening diseases. Nonetheless, its long-term effect on vascular function and inflammation in age-related obesity is still unclear. The aim of this study was to investigate the effect of regular, supervised exercise on inflammatory profile and vascular function in age-related obesity...
2018: Journal of Immunology Research
S C Heslinga, T C Konings, I E van der Horst-Bruinsma, O Kamp, V P van Halm, Hacm de Bruin-Bon, M J Peters, M T Nurmohamed
Background: Diastolic left ventricular (LV) dysfunction appears more prevalent in ankylosing spondylitis (AS). The effects of tumor necrosis factor alpha (TNF-α) blocking therapy, a strong and effective anti-inflammatory drug, on diastolic LV function in AS are unknown. The objective of the study was to find the effects of 1-year treatment with golimumab 50 mg subcutaneously once per month on systolic and diastolic LV dysfunction in AS patients. Methods: Forty consecutive AS patients were treated with TNF-α blocking therapy for 1 year...
2018: Biologics: Targets & Therapy
Paulo T Muller, Karina A M Utida, Tiago R L Augusto, Marcos V P Spreafico, Reiby C Mustafa, Ana W Xavier, Erlandson F Saraiva
BACKGROUND: Left ventricular diastolic dysfunction (LVDD) is highly prevalent in COPD and conflicting results have emerged regarding the consequences on exercise capacity in the 6MWT. We sought to examine the ventilatory efficiency and variability metrics as the primary endpoint and aerobic capacity (V'O2 ) as the secondary endpoint. METHODS: Forty subjects were included and submitted to comprehensive lung function tests, detailed pulsed-Doppler echocardiography, and cardiopulmonary exercise testing...
December 2018: Respiratory Medicine
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