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Diastolic Dysfunction Or HFpEF

Céline Guilbeau-Frugier, Marie Cauquil, Clément Karsenty, Olivier Lairez, Camille Dambrin, Bruno Payré, Hervé Cassard, Claudie Josse, Marie-Hélène Seguelas, Sophie Allart, Maxime Branchereau, Christophe Heymes, Franck Mandel, Marie-Bernadette Delisle, Atul Pathak, Etienne Dague, Jean-Michel Sénard, Céline Galés
Aims: This study explored the lateral crest structures of adult cardiomyocytes (CMs) within healthy and diseased cardiac tissue. Methods and results: Using high-resolution electron and atomic force microscopy, we performed an exhaustive quantitative analysis of the three-dimensional (3D) structure of the CM lateral surface in different cardiac compartments from various mammalian species (mouse, rat, cow and human) and determined the technical pitfalls that limit its observation...
October 17, 2018: Cardiovascular Research
Steffen Pabel, Stefan Wagner, Hannah Bollenberg, Philipp Bengel, Árpád Kovács, Christian Schach, Petros Tirilomis, Julian Mustroph, André Renner, Jan Gummert, Thomas Fischer, Sophie Van Linthout, Carsten Tschöpe, Katrin Streckfuss-Bömeke, Gerd Hasenfuss, Lars S Maier, Nazha Hamdani, Samuel Sossalla
AIMS: Empagliflozin, a clinically used oral antidiabetic drug that inhibits the sodium-dependent glucose co-transporter 2, has recently been evaluated for its cardiovascular safety. Surprisingly, empagliflozin reduced mortality and hospitalization for heart failure (HF) compared to placebo. However, the underlying mechanisms remain unclear. Therefore, our study aims to investigate whether empagliflozin may cause direct pleiotropic effects on the myocardium. METHODS AND RESULTS: In order to assess possible direct myocardial effects of empagliflozin, we performed contractility experiments with in toto-isolated human systolic end-stage HF ventricular trabeculae...
October 17, 2018: European Journal of Heart Failure
Danilo Cardim, Chiara Robba, Basil Matta, Graham Tytherleigh-Strong, Niel Kang, Bernhard Schmidt, Joseph Donnelly, Leanne Calviello, Peter Smielewski, Marek Czosnyka
Although the beach-chair position (BCP) is widely used during shoulder surgery, it has been reported to associate with a reduction in cerebral blood flow, oxygenation, and risk of brain ischaemia. We assessed cerebral haemodynamics using a multiparameter transcranial Doppler-derived approach in patients undergoing shoulder surgery. 23 anaesthetised patients (propofol (2 mg/kg)) without history of neurologic pathology undergoing elective shoulder surgery were included. Arterial blood pressure (ABP, monitored with a finger-cuff plethysmograph calibrated at the auditory meatus level) and cerebral blood flow velocity (FV, monitored in the middle cerebral artery) were recorded in supine and in BCP...
October 17, 2018: Journal of Clinical Monitoring and Computing
Lukas Weber, Hans Rickli, Philipp K Haager, Lucas Joerg, Daniel Weilenmann, Roman Brenner, Maurizio Taramasso, Philipp Baier, Francesco Maisano, Micha T Maeder
AIMS: We aimed to investigate the prevalence, detailed invasive haemodynamics, and prognostic impact of pulmonary hypertension (PH) in severe aortic stenosis (AS). METHODS AND RESULTS: We studied 503 patients (mean age 74 ± 10 years) with severe AS (indexed aortic valve area 0.4 ± 0.1 cm2 /m2 , left ventricular ejection fraction 57 ± 12%) undergoing left and right heart catheterization prior to aortic valve replacement. Median follow-up was 3...
October 17, 2018: European Journal of Heart Failure
Lingfei Li, Qiong Zhang, Xingyue Zhang, Junhui Zhang, Xuefeng Wang, Jun Ren, Jiezhi Jia, Dongxia Zhang, Xupin Jiang, Jiaping Zhang, Hao Mei, Bing Chen, Jiongyu Hu, Yuesheng Huang
BACKGROUND: Cardiac remodeling is a pathophysiological process that involves various changes in heart, including cardiac hypertrophy and fibrosis. Cardiac remodeling following pathological stimuli is common trigger leading to cardiac maladaptation and onset of heart failure, and their pathogenesis remains unclear. METHODS: Heart specimens of tetralogy of Fallot (TOF) patients, myocardial infarction (MI) and transverse aortic constriction (TAC) mouse models were collected to determine changes of microtubule associated protein 4 (MAP4) phosphorylation...
October 13, 2018: EBioMedicine
Regina Ribeiras
No abstract text is available yet for this article.
October 13, 2018: Portuguese Journal of Cardiology: An Official Journal of the Portuguese Society of Cardiology
Il Young Kim, June Hyun Kim, Min Jeong Kim, Dong Won Lee, Cheol Gu Hwang, Miyeun Han, Harin Rhee, Sang Heon Song, Eun Young Seong, Soo Bong Lee
BACKGROUND: Cardiovascular disease (CVD) is a leading cause of death in patients with chronic kidney disease (CKD). Left ventricular hypertrophy (LVH) and left ventricular diastolic dysfunction (LVDD) are known as predictors of CVD in these patients. Neutrophil gelatinase-associated lipocalin (NGAL) is a biomarker of acute kidney injury. Recently, elevated NGAL levels have been reported in patients with CVD. This study aimed to evaluate the association between plasma NGAL levels and LVH/LVDD in patients with CKD...
2018: PloS One
Lu-Xi Zou, Ling Sun
BACKGROUND: Intradialytic hypertension (IDH) is emerging as an important issue in maintenance hemodialysis (MHD) patients. This study aimed to discuss potential factors related to IDH and build forecasting models for post-dialysis blood pressure (BP) in MHD patients with IDH. METHODS: A total of 266 MHD patients were enrolled, included 133 (50%) patients with IDH and 133 patients without IDH. The BP and pulse were determined and recorded over six consecutive dialysis treatments...
October 16, 2018: Clinical and Experimental Hypertension: CHE
Pei-Hsun Sung, Sarah Chua, Kuan-Hung Chen, Cheuk-Kwan Sun, Yi-Chen Li, Chi-Ruei Huang, Chi-Wen Luo, Han-Tan Chai, Hung-I Lu, Hon-Kan Yip
This study tested the hypothesis that extracellular matrix accumulation in tPA-/- /MMP-9-/- [double-knockout (DKO)] may be protective against left ventricular (LV) remodeling and dysfunction following transverse aortic constriction (TAC)-induced hypertrophic cardiomyopathy in mice. Wild-type C57BL/6 mice (n = 20) were equally categorized into sham-control (SC1 ) and TAC1 . Similarly, DKO mice (n = 20) were equally divided into two groups (i.e., SC2 and ATC2 ). By days 28/60 after TAC, LV ejection fraction (LVEF) was significantly higher in TAC2 than TAC1 , whereas LV end-systolic/diastolic dimensions displayed an opposite pattern to LVEF between the two groups (all P < 0...
2018: American Journal of Translational Research
Madeleine Johansson, Fabrizio Ricci, Giuseppe Di Martino, Cecilia Rogmark, Richard Sutton, Viktor Hamrefors, Olle Melander, Artur Fedorowski
OBJECTIVE: To assess the role of four biomarkers of neuroendocrine activation and endothelial dysfunction in the longitudinal prediction of fragility fractures. METHODS: We analysed a population-based prospective cohort of 5415 community-dwelling individuals (mean age, 68.9±6.2 years) enrolled in the Malmö Preventive Project followed during 8.1±2.9 years, and investigated the longitudinal association between C-terminal pro-arginine vasopressin (CT-proAVP), C-terminal endothelin-1 precursor fragment (CT-proET-1), the mid-regional fragments of pro-adrenomedullin (MR-proADM) and pro-atrial natriuretic peptide (MR-proANP), and incident vertebral, pelvic and extremity fractures...
October 15, 2018: Heart: Official Journal of the British Cardiac Society
Kristof Vandekerckhove, Kathleen De Waele, Aurelie Minne, Ilse Coomans, Katya De Groote, Joseph Panzer, Catherine Dhooge, Victoria Bordon, Daniel De Wolf, Jan Boone
BACKGROUND: Physical fitness is an important determinant of quality of life (QOL) after hematopoietic stem cell transplantation. Cardiac function can influence exercise performance. The aim of this study was to assess these factors and their interrelationship. PROCEDURE: Children underwent cardiopulmonary exercise testing (CPET) at least 1 year after hematopoietic stem cell transplantation (HSCT) and were compared with healthy controls. Systolic and diastolic heart function and left ventricle (LV) wall dimensions were measured...
October 14, 2018: Pediatric Blood & Cancer
Silvio Piffer, Valeria Bignamini, Umberto Rozzanigo, Piero Poletti, Stefano Merler, Elisabetta Gremes, Domenico Marco Bonifati
INTRODUCTION AND STUDY AIM: Embolic strokes of undetermined source (ESUS) represent a rather recent diagnostic entity under clinical research for relapse prevention in cryptogenic stroke patients. Despite strict diagnostic criteria, ESUS definition ignores major clinical and radiological aspects, so including heterogeneous cases and probably influencing trial results. This study researches clinically relevant phenotypes among ESUS patients. PATIENTS AND METHODS: We evaluated ESUS patients admitted at Trento Stroke Unit over a 4-year period...
October 12, 2018: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
Miguel Guerra, Adelino F Leite-Moreira
Intraventricular pressure gradients (IVPGs) play a physiological role in normal filling and emptying of the left ventricle. Regional alterations in IVPGs might be an important factor in the characteristic changes that occur in intraventricular flow in specific cardiac disorders and may contribute to and represent an early sign of ventricular dysfunction. Diastolic IVPGs, a marker of normal ventricular filling, and systolic IVPGs, a marker of normal ventricular emptying, can be attenuated, lost entirely or even reversed when ventricular emptying is opposed by afterload elevations, after regional acute ischaemia and in failing hearts...
January 2018: Revista Portuguesa de Cirurgia Cardio-torácica e Vascular
Kotb Abbass Metwalley, Hekma Saad Farghaly, Abdelrahman Abdelhamid
BACKGROUND/AIMS: Homocysteine is an important and independent risk factor for atherosclerotic diseases. The aim of this study was to evaluate serum levels of homocysteine in children with congenital adrenal hyperplasia (CAH) and their relation to carotid artery intima-media thickness (CA-IMT) and left ventricular (LV) function. METHODS: This study included 36 children with classic CAH and 36 healthy children. All underwent anthropometric evaluation. Measurement of serum levels of total homocysteine was carried out...
October 12, 2018: Hormone Research in Pædiatrics
Constantina Aggeli, Kali Polytarchou, Dimitrios Varvarousis, Stellios Kastellanos, Dimitrios Tousoulis
Stress echocardiography (SE) is a very useful method in clinical practice, since it offers important information both for patient's functional status and hemodynamic changes during stress. Therefore, SE provides strong diagnostic and prognostic data in a wide spectrum of cardiovascular diseases. This review summarizes the clinical applications of SE in conditions beyond coronary artery disease and highlights practical recommendations and key issues for each condition that need further investigation. SE is an established method for the evaluation of symptomatic and asymptomatic patients with valvular heart disease and cardiomyopathies, and provides important information regarding prognosis and management of patients with congenital heart disease, pulmonary hypertension or diastolic dysfunction...
October 12, 2018: Clinical Cardiology
Hidekatsu Fukuta, Toshihiko Goto, Kazuaki Wakami, Takeshi Kamiya, Nobuyuki Ohte
Left ventricular (LV) diastolic dysfunction is associated with the pathophysiology of heart failure with preserved ejection fraction (HFpEF) and contributes importantly to exercise intolerance that results in a reduced quality of life (QOL) in HFpEF patients. Experimental studies have shown that aldosterone plays a role in the genesis of myocardial hypertrophy and fibrosis, thereby enhancing LV diastolic dysfunction, and that aldosterone antagonists (mineralocorticoid receptor antagonists [MRAs]) prevents myocardial hypertrophy and fibrosis...
October 12, 2018: Heart and Vessels
R Sobhy, M Samir, G Abdelmohsen, H Ibrahim, M Y Abd El Rahman, N Abdelrahman, N Behairy, O Imam, H Hamza
Rheumatic heart disease (RHD) is a major cause of morbidity and mortality in developing countries, so early diagnosis and treatment can reduce morbidity and mortality resulting from subsequent valvular damage. The aim of this study was to detect subtle myocardial dysfunction among children with RHD with preserved left ventricular systolic function. This is a cross-sectional case-control study that was conducted on 30 children with RHD (who had valvular affection of any degree and were not in activity) compared to 23 healthy children...
October 12, 2018: Pediatric Cardiology
Tien C Nguyen, Yoshiaki Ohyama, Ayako Taketomi-Takahashi, Huong T Nguyen, Akio Sugimoto, Makito Sato, Hisako Sumiyoshi, Tetsuya Nakamura, Masahiko Kurabayashi, Yoshito Tsushima
PURPOSE: To evaluate the correlation between cardiac functional parameters and image quality in coronary computed tomography angiography (CCTA). MATERIAL AND METHODS: Sixty-six patients who underwent both CCTA and echocardiography were included. The coronary artery attenuation values and contrast-to-noise ratios (CNR) were measured in the proximal right coronary arteries (RCA) and left main (LM) trunk. Then, the averages of the mean values derived from RCA and LM were calculated...
October 6, 2018: Clinical Imaging
Alsayed Salem, Ahmed Moustafa Ewiss Abdelgawad, Ahmed Elshemy
BACKGROUND: Rheumatic heart disease (RHD) is the leading cause of mitral valve disease in the developing world. In general, mitral valve repair is preferred over replacement. Although it is very successful in degenerative disease, its results in the rheumatic valve are not as successful as that for degenerative repair. Our approach has been to repair rheumatic mitral valves when the anatomic substrate appears to permit it, and we aimed by this study to present our immediate and midterm follow-ups of our cohort of rheumatic valve repair patients...
August 14, 2018: Heart Surgery Forum
Gee Hee Kim, Jung Sun Cho, Woo-Baek Chung, Chan Seok Park, Sang Hyun Ihm
Left atrial (LA) strain is known to exhibit an early progressive reduction in hypertensive patients with diastolic dysfunction. However, an association of the renin-angiotensin-*aldosterone system (RAAS) with LA deformation has not been found in these patients. We aimed to investigate the association of plasma aldosterone concentration (PAC) and 24-hour ambulatory blood pressure monitoring (ABPM) with LA and left ventricle (LV) deformation in never-treated early hypertensive patients. This cross-sectional study included 101 never-treated subjects who were registered in a working group at The Catholic University of Korea...
October 12, 2018: Clinical and Experimental Hypertension: CHE
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