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Diastolic Dysfunction Or HFpEF

Nathalie J M Bravo-Valenzuela, Paulo Zielinsky, Jesús Zurita-Peralta, Luiz Henrique Nicoloso, Antonio Piccoli, Luiza Ferreira Van der Sand, Natássia Miranda Sulis, Camila Carvalho Ritter
INTRODUCTION: In intrauterine growth restriction (IUGR), increased uteroplacental vascular impedance contributes to preferential flow to left ventricle (LV), with consequent alteration of its compliance and increased left atrial (LA) pressure. Pulmonary vein pulsatility index (PVPI) reflects the increased impedance to LA filling and could be used as a cardiac monitoring parameter in IUGR. MATERIAL AND METHODS: A total of 27 IUGR fetuses (group 1), 28 fetuses with appropriate growth for gestational age from hypertensive mothers (group 2), and 28 controls (group 3) were studied...
August 17, 2018: Fetal Diagnosis and Therapy
Yixiu Zhao, Xin Zhang, Jing Luan, Buchang Zhao, Na An, Na Sun, Xinhui Wang, Tao Zhao, Yanhong Sun, Zidong Donna Fu, Yan Zhang, Yan Zhang
BACKGROUND/AIMS: Shenxian-shengmai (SXSM) oral liquid, a Chinese patent compound medicine, has been used to treat sinus bradyarrhythmias induced by mild sick sinus syndrome in clinical practice. Myocardial ischemia, in particular in serious or right coronary-related heart diseases, can cause bradyarrhythmias and cardiac dysfunction. Moreover, reperfusion of ischemic myocardium is associated with additional myocardial damage known as myocardial ischemia-reperfusion (I/R) injury. This study was designed to evaluate the effects of SXSM on bradyarrhythmias and cardiac dysfunction induced by myocardial I/R injury, and to explore the underlying mechanisms...
August 17, 2018: Cellular Physiology and Biochemistry
Elisa Zaragoza-Macias, Ali N Zaidi, Nandini Dendukuri, Ariane Marelli
Patients with systemic morphological right ventricles (RVs), including congenitally corrected transposition of the great arteries and dextro-transposition of the great arteries with a Mustard or Senning atrial baffle repair, have a high likelihood of developing systemic ventricular dysfunction. Unfortunately, there are a limited number of clinical studies on the efficacy of medical therapy for systemic RV dysfunction. We performed a systematic review and meta-analysis to assess the effect of angiotensin-converting enzyme (ACE) inhibitors, angiotensin-receptor blockers (ARBs), beta blockers, and aldosterone antagonists in adults with systemic RVs...
August 9, 2018: Journal of the American College of Cardiology
Ercan Yuvanc, Mehmet Tolga Dogru, Vedat Simsek, Hüseyin Kandemir, Devrim Tuglu
PURPOSE: Hypertension (HT) is known to be of the main risk factors for erectile dysfunction (ED). But non-dipping (<%10 drop in the night) of HT is not investigated truly. The aim of this study was to test the hypothesis that the non-dipper hypertensive patients are more prone to develop erectile dysfunction. MATERIALS AND METHODS: This was a cross-sectional clinical study. 70 HT patients diagnosed by Ambulatory blood pressure monitoring (ABPM) were classified into 3 groups (No ED, mild to moderate and severe) according to their International Index of Erectile Function (IIEF) scores...
August 18, 2018: Urology Journal
Leônidas Graças Mendes-Junior, Leandro Ceotto Freitas-Lima, Janaína Ribeiro Oliveira, Marcos B Melo, Carlos Eduardo Mendes D'Angelis, Jonh David Feltenberger, Igor Viana Brandi, Bruna Mara Aparecida Carvalho, André Luiz Sena Guimarães, Alfredo Maurício Batista De Paula, Carlos Eduardo Mendes D'Angelis, Maria José Campagnole-Santos, Robson Augusto Souza Santos, Valdir Andrade Braga, Sérgio Henrique Sousa Santos
Diabetic cardiomyopathy (DC) describes diabetes-associated changes in the structure and function of myocardium that are not directly linked to other factors such as hypertension. Currently there are some models of DC; however, they take a large time period to mimic key features. In the present study, we investigated the effects of a short-term high-fat/high salt diet (HFHS) treatment on myocardial function and structure, and vascular reactivity in C57BL/6 male mice. After 14 weeks HFHS induced hypertension (MAP = 144...
August 14, 2018: Life Sciences
Shigang Qiao, Guofang Mao, Hua Li, Zhimin Ma, Lei Hong, Huiling Zhang, Chen Wang, Jianzhong An
Background: Chronic overnutrition leads to cardiac dysfunction and insulin (INS) resistance. Dipeptidyl peptidase-4 (DPP-4) improves glucose metabolism and insulin sensitivity in both human and animal models. In this study, we explored whether DPP-4 inhibitor sitagliptin (SIT) is involved in the protection of cardiac function and β -cell function using an obesity female mouse model. Methods: Six-week-old C57BL6/J mice were fed a high fat and fructose Western diet with DPP-4 inhibitor SIT for 12 weeks...
2018: Journal of Diabetes Research
Sunit Tolia, Zubair Khan, Gunjan Gholkar, Marcel Zughaib
Background: Routine ambulatory echocardiographic estimates of left ventricular (LV) filling pressures are not cost-effective and are occasionally fraught with anatomic, physiologic as well as logistical limitations. The use of implantable hemodynamic devices such as CardioMEMS Heart Failure (HF) System has been shown to reduce HF-related readmission rates by remote monitoring of LV filling pressures. Little is known about the correlation between CardioMEMS and echocardiography-derived estimates of central hemodynamics...
2018: Cardiology Research and Practice
Sahand Hamidi, Javad Kojuri, Armin Attar, Jamshid Roozbeh, Alireza Moaref, Mohammad Hossein Nikoo
Introduction: Cardiac dysfunction is a major cause of morbidity and mortality in patients with end-stage renal disease (ESRD). Previous studies have shown that kidney transplantation can reverse some of the gross changes in the myocardial structure such as left ventricular ejection fraction (LVEF) and volumes. Whether kidney transplantation can reverse the subtle and early myocardial changes in ESRD patients who do not suffer from gross alternations in myocardial function is not yet studied. The aim of this study was to answer this question...
2018: Journal of Cardiovascular and Thoracic Research
Muriela Silva, Eduarda Pereira, Afonso Rocha, Dulce Sousa, Bruno Peixoto
Introduction: Prospective studies have shown the relation between acute coronary syndrome (ACS) and neurocognitive dysfunction with prevalence ranging between 10.51% and 66.8%. The present study aims to determine the prevalence level of neurocognitive dysfunction; the relations between sociodemographic, clinical and emotional variables and neurocognitive functioning in a sample of ACS patients. Methods: The sample comprised of 53 patients engaged in cardiac rehabilitation within 3 months after an ACS. Patients with any medical history of neuropsychiatric problems prior to the ACS and illiterate subjects were not included in the study...
2018: Journal of Cardiovascular and Thoracic Research
Hilary M DuBrock, Omar F AbouEzzeddine, Margaret M Redfield
BACKGROUND: Microvascular inflammation may contribute to the pathogenesis of both heart failure with preserved ejection fraction (HFpEF) and pulmonary hypertension (PH). We investigated whether the inflammation biomarker C-reactive protein (CRP) was associated with clinical characteristics, disease severity or PH in HFpEF. METHODS: Patients in the Phosphodiesterase-5 Inhibition to Improve Clinical Status and Exercise Capacity in Diastolic Heart failure (RELAX) trial had baseline high-sensitivity CRP levels measured (n = 214)...
2018: PloS One
Bert Andersson, Lilin She, Ru-San Tan, Panniyammakal Jeemon, Krzysztof Mokrzycki, Matthias Siepe, Alexander Romanov, Liliana E Favaloro, Ljubomir T Djokovic, P Krishnam Raju, Piotr Betlejewski, Normand Racine, Adam Ostrzycki, Weerachai Nawarawong, Siuli Das, Jean L Rouleau, George Sopko, Kerry L Lee, Eric J Velazquez, Julio A Panza
Aims: Hypertension (HTN) is a well-known contributor to cardiovascular disease, including heart failure (HF) and coronary artery disease, and is the leading risk factor for premature death world-wide. A J- or U-shaped relationship has been suggested between blood pressure (BP) and clinical outcomes in different studies. However, there is little information about the significance of BP on the outcomes of patients with coronary artery disease and left ventricular dysfunction. This study aimed to determine the relationship between BP and mortality outcomes in patients with ischaemic cardiomyopathy...
August 2, 2018: European Heart Journal
Jill M Wecht, Joseph P Weir, Caitlyn G Katzelnick, Glenn Wylie, Mastanna Eraifej, Nhuguynh Nguyen, Trevor Dyson-Hudson, William A Bauman, Nancy Chiaravalotti
Cognitive deficits are prevalent in the spinal cord injury (SCI) population, and consensus suggests that concomitant traumatic brain injury or co-morbid conditions are primarily responsible for these deficits. However, mounting evidence supports the possibility that systemic and cerebral hemodynamic dysfunction may contribute to the cognitive deficits reported in persons with SCI. We sought to determine the contribution of changes in blood pressure (BP) and changes in cerebral blood flow velocity (CBFv) to test performance on the Symbol Digit Modalities Test (SDMT) in persons with SCI compared to matched nonSCI controls...
August 16, 2018: Journal of Neurotrauma
Ahmit Gupta, Steven R Bailey
PURPOSE OF REVIEW: This article provides an update on percutaneous devices to treat diastolic dysfunction, current clinical experience, and actively enrolling trials. We also discuss potential complications and limitations of devices. RECENT FINDINGS: Exertional symptoms including exertional dyspnea and exercise intolerance are common features of heart failure that are driven by left ventricular and left atrial non-compliance that results in pulmonary vascular congestion...
August 15, 2018: Current Cardiology Reports
Wei-Wei Hao, Su-Li Zhang, Yan Sun, Li-Na Bai, Jing-Wei Bian, Hai-Cun Yu, Xiao-Chen Yin, Peng-Li Wang, Hui-Rong Liu
Myocardial fibrosis (MF) is an important pathological process of cardiac remodeling in patients with heart failure; however its etiology has not been clear. It has been known that the angiotensin II type 1 receptor autoantibody (AT1-AA) is present in patients with heart failure, but it is unclear whether this antibody directly causes MF. In this study, we investigated the role of AT1-AA in MF and its effects on cardiac fibroblasts (CFs). The AT1-AA positive rat model was established by active immunization method, and the measurement of indexes were made in the 8th week after active immunity...
August 25, 2018: Sheng Li Xue Bao: [Acta Physiologica Sinica]
Bing Han, Qingli Wang
Pulmonary hypertension due to left heart disease (PH-LHD) is caused by left ventricular (LV) systolic and/or diastolic dysfunction and left heart valve disease. LV diseases lead to left ventricular filling pressure increases, pulmonary venous obstruction and pulmonary venous pressure increases, and thus to secondary PH. Exercise tolerance is lower and fatality rates are higher in patients with PH-LHD than those in subjects with normal pulmonary arterial pressure. In spite of the progress in the study of the mechanisms of PH-LHD in recent years, no specific treatment is currently available...
August 2018: Experimental and Therapeutic Medicine
I Tong Mak, Joanna J Chmielinska, Christopher F Spurney, William B Weglicki, Jay H Kramer
Chronic effects of a combination antiretroviral therapy (cART = tenofovir/emtricitatine + atazanavir/ritonavir) on systemic and cardiac oxidative stress/injury in HIV-1 transgenic (Tg) rats and protection by Mg-supplementation were assessed. cART (low doses) elicited no significant effects in normal rats, but induced time-dependent oxidative/nitrosative stresses: 2.64-fold increased plasma 8-isoprostane, 2.0-fold higher RBC oxidized glutathione (GSSG), 3.2-fold increased plasma 3-nitrotyrosine (NT), and 3-fold elevated basal neutrophil superoxide activity in Tg rats...
August 15, 2018: International Journal of Molecular Sciences
Friederike Lindemann, David Kuerten, Eva Koch, Matthias Fuest, Claudia Fischer, Andreas Voss, Niklas Plange
PURPOSE: Vascular dysfunction and ischemia are believed to play an important part in the pathogenesis of glaucoma and especially of normal tension glaucoma (NTG). The aim of the present study was to analyze the blood pressure (BP) and heart rate variability patterns in patients with primary open-angle glaucoma (POAG) and NTG compared with controls. METHODS: In total, 37 patients with POAG, 27 patients with NTG, and 82 control subjects were included in a prospective clinical validation study...
August 15, 2018: Current Eye Research
Peter Blomstrand, Peter Sjöblom, Mats Nilsson, Magnus Wijkman, Martin Engvall, Toste Länne, Fredrik H Nyström, Carl Johan Östgren, Jan Engvall
AIMS: Obesity is associated with type 2 diabetes mellitus, left ventricular diastolic dysfunction and heart failure but it is unclear to which extent it is related to left ventricular systolic dysfunction. The aim of the study was to explore the effects of overweight and obesity on left ventricular systolic function in patients with type 2 diabetes mellitus and a control group of non-diabetic persons. METHODS: We prospectively investigated 384 patients with type 2 diabetes mellitus, and 184 controls who participated in the CARDIPP and CAREFUL studies...
August 14, 2018: Cardiovascular Diabetology
Michael DiLorenzo, Wei-Ting Hwang, Elizabeth Goldmuntz, Bonnie Ky, Laura Mercer-Rosa
BACKGROUND: Right ventricular (RV) systolic dysfunction has been associated with adverse outcomes in tetralogy of Fallot (TOF). However, the role and etiology of diastolic dysfunction remain incompletely defined. We assessed the association between traditional echocardiographic measures of diastolic function with catheter-based RV end-diastolic pressure (RVEDP) and identified clinical characteristics independently associated with diastolic dysfunction. METHODS: Single-center, retrospective cohort study of surgically repaired TOF patients undergoing cardiac catheterization with echocardiograms within 3 months prior to the catheterization...
August 13, 2018: Echocardiography
Hong-Kui Yu, Bei Xia, Xiao Liu, Chunxi Han, Weiling Chen, Zhihui Li
Three-dimensional (3D) speckle-tracking echocardiography (STE) is a new imaging modality used for quantitative analysis of left ventricular (LV) function. The aim of this study is to assess the value of 3D STE in early detection of subclinical myocardial involvement in children with Duchenne muscular dystrophy (DMD). Fifty-six children with DMD (mean age, 8.8 ± 1.9 years) and 31 age-matched control subjects were studied. Patients were subdivided into two groups by age: ≤ 8 or > 8 years. Standard echocardiography examinations were performed to measure LV size and ejection fraction (EF)...
August 13, 2018: International Journal of Cardiovascular Imaging
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