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https://www.readbyqxmd.com/read/29927838/-logistics-in-coordinating-the-first-adult-trans-atlantic-bilateral-hand-transplant-lessons-learned
#1
Oded Ben-Amotz, Erwin A Kruger, Christine McAndrew, David Bozentka, David Steinberg, Benjamin Chang, Laurent Lantieri, L Scott Levin
Hand transplantation requires precise preoperative planning and surgical execution. Coordinating a transplant team-including surgeons, anesthesiologists, nurses, and supporting staff-is a time-sensitive challenge when a donor-recipient match is confirmed. International human limb transplantation occurs when the recipient and donor are in separate countries. We describe the logistics behind the first trans-Atlantic adult bilateral hand transplantation, which, to date, required the highest level of coordination and timing...
June 12, 2018: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/29922299/the-emerging-link-between-the-complement-cascade-and-purinergic-signaling-in-stress-hematopoiesis
#2
REVIEW
Mariusz Z Ratajczak, Mateusz Adamiak, Magda Kucia, William Tse, Janina Ratajczak, Wieslaw Wiktor-Jedrzejczak
Innate immunity plays an important role in orchestrating the immune response, and the complement cascade (ComC) is a major component of this ancient defense system, which is activated by the classical-, alternative-, or mannan-binding lectin (MBL) pathways. However, the MBL-dependent ComC-activation pathway has been somewhat underappreciated for many years; recent evidence indicates that it plays a crucial role in regulating the trafficking of hematopoietic stem/progenitor cells (HSPCs) by promoting their egress from bone marrow (BM) into peripheral blood (PB)...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29920932/genetic-immune-and-inflammatory-markers-associated-with-diabetes-in-solid-organ-transplant-recipients
#3
Lina Quteineh, Agnieszka Wójtowicz, Pierre-Yves Bochud, Severine Crettol, Frederik Vandenberghe, Jean-Pierre Venetz, Oriol Manuel, Dela Golshayan, Roger Lehmann, Nicolas J Mueller, Isabelle Binet, Christian van Delden, Jürg Steiger, Paul Mohacsi, Jean-Francois Dufour, Paola M Soccal, Zoltan Kutalik, Pedro Marques-Vidal, Peter Vollenweider, Mike Recher, Christoph Hess, Manuel Pascual, Chin B Eap
New-onset diabetes after transplantation (NODAT) is a complication following solid organ transplantation (SOT) and may be related to immune or inflammatory responses. We investigated whether single nucleotide polymorphisms (SNPs) within 158 immune- or inflammation-related genes contribute to NODAT in SOT recipients. The association between 263 SNPs and NODAT were investigated in a discovery sample of SOT recipients from the Swiss Transplant Cohort Study (STCS, n1 =696). Positive results were tested in a first STCS replication sample (n2 =489) and SNPs remaining significant after multiple test corrections were tested in a second SOT replication sample (n3 =156)...
June 19, 2018: American Journal of Transplantation
https://www.readbyqxmd.com/read/29920643/the-microbiome-in-autoimmune-diseases
#4
REVIEW
Fabrizio De Luca, Yehuda Shoenfeld
The microbiome is represented by microorganisms which live in a symbiotic way with the mammalian. The microorganisms have the ability to influence different physiological aspects such as the immune system, metabolism and behaviour. In the last years, several studies have highlighted the role of the microbiome in the pathogenesis of autoimmune diseases. Notably, in systemic lupus erythematosus an alteration of the intestinal flora (lower Firmicutes/Bacteroidetes ratio) was described. On the other hand, changes to the gut commensal and periodontal disease were proposed as important factors to the pathogenesis of rheumatoid arthritis...
June 19, 2018: Clinical and Experimental Immunology
https://www.readbyqxmd.com/read/29914392/three-novel-mutations-in-the-atp7b-gene-of-unrelated-vietnamese-patients-with-wilson-disease
#5
Nguyen Thi Mai Huong, Nguyen Thi Kim Lien, Ngo Diem Ngoc, Nguyen Thi Phuong Mai, Nguyen Pham Anh Hoa, Le Thanh Hai, Phan Van Chi, Ta Thanh Van, Tran Van Khanh, Nguyen Huy Hoang
BACKGROUND: Wilson disease (OMIM # 277900) is a autosomal recessive disorder characterized by accumulation of copper in liver and brain. The accumulation of copper resulting in oxidative stress and eventually cell death. The disease has an onset in a childhood and result in a significant neurological impairment or require lifelong treatment. Another serious consequence of the disease is the development of liver damage and acute liver failure leading to liver transplant. The disorder is caused by mutations in the ATP7B gene, encoding a P-type copper transporting ATPase...
June 18, 2018: BMC Medical Genetics
https://www.readbyqxmd.com/read/29913041/the-ethics-of-organ-donation-donation-after-circulatory-determination-of-death-and-xenotransplantation-from-an-islamic-perspective
#6
Aasim I Padela, Rosie Duivenbode
Donation after circulatory determination of death (DCDD) and xenotransplantation are advanced as possible solutions to the growing gap between the number of individuals in need of organ transplantation and the pool of donors. Investigating how various publics, including religious leaders, might view these "therapies" is essential for broad public and professional support and will be needed in order to make these solutions viable. This study, therefore, presents normative Islamic bioethical perspectives on donation after circulatory determination of death and xenotransplantation...
May 2018: Xenotransplantation
https://www.readbyqxmd.com/read/29907807/availability-of-hla-allele-matched-unrelated-donors-estimation-from-haplotype-frequency-in-the-japanese-population
#7
Satoshi Nishiwaki, Hidenori Tanaka, Hiroto Kojima, Shinichiro Okamoto
A human leukocyte antigen (HLA)-matched unrelated donor is the primary alternative donor for allogeneic hematopoietic cell transplantation in Japan. In considering an optimal donor registry size, the availability of HLA-matched donors is important. In this study, the probability of finding an HLA-A, -B, -C, and -DRB1 allele-matched donor was estimated using two different methods based on the haplotype frequencies in the Japanese population: an actual measurement method (AMM) and a formula method (FM). According to AMM, the probabilities of finding an HLA-matched donor were 40...
June 15, 2018: Bone Marrow Transplantation
https://www.readbyqxmd.com/read/29904028/prognosis-and-follow-up-of-idiopathic-pulmonary-fibrosis
#8
REVIEW
Estrella Fernández Fabrellas, Ricardo Peris Sánchez, Cristina Sabater Abad, Gustavo Juan Samper
Idiopathic pulmonary fibrosis (IPF), a devastating progressive interstitial lung disease (ILD) with no known cause, is the most common and deadly of the idiopathic interstitial pneumonias. With a median survival of 3⁻5 years following diagnosis, IPF is characterized by a progressive decline in lung function and quality of life in most patients. Prognostic factors recognized classically that influence mortality include functional, clinical and radiological parameters. However, in recent years, there has also been progress in the knowledge of genetic factors and biomarkers that may be useful in the prognostic evaluation of these patients...
June 14, 2018: Medical Sciences: Open Access Journal
https://www.readbyqxmd.com/read/29903852/transplants-for-non-lethal-conditions-a-case-against-hand-transplantation-in-minors
#9
Charles E Hedges, Philip M Rosoff
Human allografts for life-threatening organ failure have been demonstrated to be lifesaving and are now considered to be standard of care for many conditions. Transplantation of non-vital anatomic body parts has also been accomplished. Hand transplantation after limb loss in adults has been shown to offer some promising benefits in both functional and psychological measures in preliminary studies. It has been suggested to expand eligibility criteria to include minors, with one such operation having already been performed...
June 14, 2018: Journal of Medical Ethics
https://www.readbyqxmd.com/read/29894408/long-term-topical-corticosteroid-use-and-risk-of-skin-cancer-a-systematic-review
#10
Sonia Ratib, Esther Burden-Teh, Jo Leonardi-Bee, Catherine Harwood, Fiona Bath-Hextall
OBJECTIVE: The objective of this systematic review was to synthesize available research evidence to determine the risk of skin cancer in patients with long-term use of topical corticosteroids (TCS). INTRODUCTION: Topical corticosteroids are one of the most commonly prescribed medicines in dermatology and the mainstay of the treatment of atopic dermatitis and other skin conditions such as psoriasis. They are often required for months or years to control the disease and ultimately restore patients' quality of life...
June 2018: JBI Database of Systematic Reviews and Implementation Reports
https://www.readbyqxmd.com/read/29892294/the-interleukin-20-cytokine-family-in-liver-disease
#11
REVIEW
Esther Caparrós, Rubén Francés
The three main causes of inflammation and chronic injury in the liver are viral hepatitis, alcohol consumption, and non-alcoholic steatohepatitis, all of which can lead to liver fibrosis, cirrhosis, and hepatocellular carcinoma, which in turn may prompt the need for liver transplant. The interleukin (IL)-20 is a subfamily part of the IL-10 family of cytokines that helps the liver respond to damage and disease, they participate in the control of tissue homeostasis, and in the immunological responses developed in this organ...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29879365/bone-marrow-stromal-cells-promote-innervation-of-bioengineered-teeth
#12
M Strub, L Keller, Y Idoux-Gillet, H Lesot, F Clauss, N Benkirane-Jessel, S Kuchler-Bopp
Transplantation of bone marrow mesenchymal stem cells (BMDCs) into a denervated side of the spinal cord was reported to be a useful option for axonal regeneration. The innervation of teeth is essential for their function and protection but does not occur spontaneously after injury. Cultured reassociations between dissociated embryonic dental mesenchymal and epithelial cells and implantation lead to a vascularized tooth organ regeneration. However, when reassociations were coimplanted with a trigeminal ganglion (TG), innervation did not occur...
June 1, 2018: Journal of Dental Research
https://www.readbyqxmd.com/read/29870507/procurement-of-extended-vascularized-skin-flaps-from-the-donor-enables-hand-transplantation-in-severe-upper-extremity-burns-an-anatomical-study
#13
Edoardo Dalla Pozza, Bahar Bassiri Gharb, Francis A Papay, Richard L Drake, Andrew Steckler, Antonio Rampazzo
BACKGROUND: Hand transplantation in patients with severe upper extremity burns can be associated with an increased risk of exposure of vessels, tendons and nerves because of extensive skin and soft tissue deficit. This study evaluated how to reliably transfer additional extended skin flaps with a standard hand allograft. METHODS: Twenty-five upper extremities were used. Sixteen were injected with latex to map the perforating branches of the brachial (BA), superior ulnar collateral (SUCA), radial (RA), ulnar (UA) and posterior interosseous (PIA) arteries...
May 19, 2018: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/29868012/late-development-of-fc%C3%AE%C2%B5r%C3%AE-neg-adaptive-natural-killer-cells-upon-human-cytomegalovirus-reactivation-in-umbilical-cord-blood-transplantation-recipients
#14
Letizia Muccio, Michela Falco, Alice Bertaina, Franco Locatelli, Francesco Frassoni, Simona Sivori, Lorenzo Moretta, Alessandro Moretta, Mariella Della Chiesa
In human natural killer (NK) cells, human cytomegalovirus (HCMV) has been shown to be a driving force capable of inducing the expansion of a highly differentiated NKG2C+ CD57+ subset, persisting over time in both HCMV+ healthy subjects and umbilical cord blood transplantation (UCBT) recipients experiencing HCMV viral reactivation. In HCMV+ healthy subjects, such expanded NK-cells are characterized by epigenetic modifications that modulate their phenotypic and functional characteristics. In particular, an enhanced ADCC activity is detectable in NK cells lacking the signaling protein FcεRγ...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29807842/partial-hand-transplant-lessons-learned-from-cadaveric-dissection-studies
#15
Valeriy Shubinets, Christine McAndrew, Jaclyn Mauch, Alyssa Ricker Glennon, Stephen J Kovach, Benjamin L Gray, David R Steinberg, David J Bozentka, Laurent Lantieri, Benjamin Chang, L Scott Levin, Ines C Lin
As the field of vascularized composite allotransplantation continues to expand, new upper extremity transplant candidates are being considered. We recently evaluated a bilateral amputee who had a mid-forearm amputation and a contralateral metacarpal hand amputation. In the latter limb, a "partial" hand transplant that preserved the majority of the patient's existing hand, including a partially severed thumb with intact thenar muscle function, was proposed. The feasibility of this partial hand transplant was studied in fresh-frozen cadaver limbs...
May 25, 2018: Journal of Hand Surgery
https://www.readbyqxmd.com/read/29781812/pim-2-protein-kinase-negatively-regulates-t-cell-responses-in-transplantation-and-tumor-immunity
#16
Anusara Daenthanasanmak, Yongxia Wu, Supinya Iamsawat, Hung D Nguyen, David Bastian, MengMeng Zhang, M Hanief Sofi, Shilpak Chatterjee, Elizabeth G Hill, Shikhar Mehrotra, Andrew S Kraft, Xue-Zhong Yu
PIM kinase family members play a crucial role in promoting cell survival and proliferation via phosphorylation of their target substrates. In this study, we investigated the role of the PIM kinases with respect to T cell responses in transplantation and tumor immunity. We found that the PIM-2 isoform negatively regulated T cell responses to alloantigen, in contrast to the PIM-1 and PIM-3 isoforms, which acted as positive regulators. T cells deficient in PIM-2 demonstrated increased T cell differentiation toward Th1 subset, proliferation, and migration to target organs after allogeneic bone marrow transplantation, resulting in dramatically accelerated graft-versus-host disease (GVHD) severity...
May 21, 2018: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/29781456/how-can-a-personal-connection-build-confidence-in-your-graduate-nursing-journey
#17
Grace Tueffel
I wrapped my bright yellow stethoscope around my neck, pockets heavy with essential nursing tools and my clipboard clenched in my right hand. It was my first shift off orientation on the bone marrow transplantation unit at a teaching hospital in North Carolina. As I listened to the change-of-shift report, I felt my nerves on edge. I repeated "be the best nurse you can be" over and over in my head as I did my best to keep calm on that first day. That is what I remember from the first day and now, a few months later, I can reflect on what I learned and what "be the best nurse you can be" means to me...
June 1, 2018: Clinical Journal of Oncology Nursing
https://www.readbyqxmd.com/read/29779314/-impact-of-psoas-muscle-index-on-early-postoperative-mortality-and-complications-after-liver-transplantation
#18
J C Hou, H Zheng, Z Qiang, Y M Zhang, W T Jiang, W Gao, J Z Cai, J J Zhang, Z Y Shen
Objective: To investigate the relationship between psoas muscle index (PMI) and early postoperative survival rate and the incidence of complications after liver transplantation in adults. Methods: The clinical data of 225 patients (male, n =184; female, n =41) underwent liver transplantation at the Organ Transplantation Department of First Central Clinic Institute of Tianjin Medical University from January 2014 to December 2016 were analyzed, retrospectively.Original disease: hepatitis B liver cirrhosis(44 cases), hepatitis C cirrhosis(10 cases), autoimmune liver cirrhosis(29 cases), other benign liver diseases(24 cases), liver cirrhosis with liver cancer(116 cases), hilar cholangiocarcinoma(1 case) and hepatic vascular sarcoma(1 case)...
May 1, 2018: Zhonghua Wai Ke za Zhi [Chinese Journal of Surgery]
https://www.readbyqxmd.com/read/29775981/from-auto-to-allotransplantation-immunomodulatory-protocol-for-hand-and-arm-transplantation
#19
W P Andrew Lee, Jaimie T Shores, Gerald Brandacher
AIM:  To achieve a favorable risk-benefit balance for hand transplantation, an immunomodulatory protocol was developed in the laboratory and translated to clinical application. METHODS:  Following donor bone marrow infusion into transplant recipients, hand and arm allografts have been maintained on low-dose tacrolimus monotherapy. RESULTS:  Good-to-excellent functional recovery has been achieved in patients compliant with medication and therapy, thus restoring autonomous and productive lives...
May 18, 2018: Journal of Reconstructive Microsurgery
https://www.readbyqxmd.com/read/29762828/neoplasms-and-renal-transplantation-impact-of-gender-comorbidity-and-age-on-in-hospital-mortality-a-retrospective-study-in-the-region-emilia-romagna-of-italy
#20
F Fabbian, A De Giorgi, R Tiseo, R Cappadona, B Zucchi, M Rubbini, F Signani, A Storari, R De Giorgio, G La Manna, R Manfredini
OBJECTIVE: The aim of this retrospective study was to investigate the relationship between cancer, non-immunologic comorbidity, estimated by International Classification of Diseases, 9th Revision, Clinical Modification (ICD-9-CM) codification, gender and in-hospital mortality (IHM) in a large sample of renal transplant recipients (RTRs) living in the region Emilia-Romagna (RER) of Italy. PATIENTS AND METHODS: We evaluated IHM in RTRs admitted between 2000 and 2013 recorded in the RER database...
April 2018: European Review for Medical and Pharmacological Sciences
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