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https://www.readbyqxmd.com/read/30324413/patients-with-prostate-cancer-and-androgen-deprivation-therapy-have-increased-risk-of-fractures-a-study-from-the-fractures-and-fall-injuries-in-the-elderly-cohort-frailco
#1
M Wallander, K F Axelsson, D Lundh, M Lorentzon
Osteoporosis is a common complication of androgen deprivation therapy (ADT). In this large Swedish cohort study consisting of a total of nearly 180,000 older men, we found that those with prostate cancer and ADT have a significantly increased risk of future osteoporotic fractures. INTRODUCTION: Androgen deprivation therapy (ADT) in patients with prostate cancer is associated to increased risk of fractures. In this study, we investigated the relationship between ADT in patients with prostate cancer and the risk of incident fractures and non-skeletal fall injuries both compared to those without ADT and compared to patients without prostate cancer...
October 15, 2018: Osteoporosis International
https://www.readbyqxmd.com/read/30311093/the-role-of-the-fracture-liaison-service-fls-in-subsequent-fracture-prevention-in-the-extreme-elderly
#2
Ilknur Sanli, Sven H van Helden, René H M Ten Broeke, Piet Geusens, Joop P W Van den Bergh, Peter R G Brink, Martijn Poeze
BACKGROUND: Several guidelines recommend a bone and fall-related osteoporosis risk assessment in all patients with fracture and age > 50 years. In practice, however, there is no consensus whether screening > 85 years is useful. AIM: To evaluate the subsequent fracture risk in all patient > 85 years, comparing the two populations of Fracture Liaison Service (FLS) attenders and non-attenders. METHODS: All patients > 85 years that presented at the FLS with a non-vertebral fracture were included in the study during a 5-year period (September 2004 and December 2009)...
October 11, 2018: Aging Clinical and Experimental Research
https://www.readbyqxmd.com/read/30310959/prevalence-risk-factors-and-therapeutic-aspects-of-injuries-and-accidents-in-women-with-epilepsy
#3
René Danilo Verboket, Nicolas Söhling, Ingo Marzi, Esther Paule, Susanne Knake, Felix Rosenow, Adam Strzelczyk, Laurent Maximilian Willems
BACKGROUND: Epilepsy-related injuries and accidents (ERIA) are a frequent cause of hospitalisation and represent a relevant burden for patients with epilepsy. In particular, osteoporosis and other gender-specific aspects may increase the risk of seizure-related fractures and injuries in women with epilepsy. AIM AND SCOPE: The aim of this analysis is to determine the prevalence and clinical nature of ERIA in a cohort of women with epilepsy, to identify possible determinants including osteoporosis and to give an overview of the current knowledge of clinically important prophylactic and therapeutic aspects...
October 11, 2018: European Journal of Trauma and Emergency Surgery: Official Publication of the European Trauma Society
https://www.readbyqxmd.com/read/30310769/perception-of-peri-menopausal-and-postmenopausal-lebanese-women-on-osteoporosis-a-cross-sectional-study
#4
Hala Ahmadieh, Ahmad Basho, Amal Chehade, Adeeb Al Mallah, Ahmad Dakour
Introduction: Osteoporosis is a generalized skeletal disorder characterized by decreased bone mineral density and microarchitectural deterioration, resulting in increased susceptibility to fractures. The prevalence of osteoporosis in Lebanon, defined as T-score <-2.5 at the total hip using NHANES gender-specific database was estimated to be 31% among postmenopausal women. Purpose: To assess the general perception of osteoporosis among women in Lebanon as well as their general knowledge of its lifestyle, risk factors, diagnostic, preventive and therapeutic measures...
December 2018: Journal of Clinical & Translational Endocrinology
https://www.readbyqxmd.com/read/30298174/association-between-high-levels-of-parathyroid-hormone-and-frailty-the-nepean-osteoporosis-and-frailty-nof-study
#5
L Murthy, P Dreyer, P Suriyaarachchi, F Gomez, C L Curcio, D Boersma, G Duque
BACKGROUND: Frailty is associated with poor outcomes hence identification of risks factors is pivotal. Since the independent role of parathyroid hormone (PTH) in frailty remains unexplored, we aimed to determine this in a population of older individuals with a history of falling. DESIGN: Cross-sectional study. SETTING: Falls and Fracture Clinic, Nepean Hospital (Penrith, Australia). PARTICIPANTS: 692 subjects (mean age=79, 65% women) assessed between 2009-2015...
2018: Journal of Frailty & Aging
https://www.readbyqxmd.com/read/30296993/current-imaging-techniques-in-osteoporosis
#6
REVIEW
John J Carey, Bjoern Buehring
Osteoporosis is a global pandemic affecting children, men and women of all ages and ethnicities. Millions of people suffer fragility fractures each year around the world as a result of this bone disease, which can have devastating consequences for them, including permanent disability and death. Many fractures are preventable by identifying people at high risk for fracture and falls, and diagnosing those who already have osteoporosis, before they fracture. Rheumatologists commonly encounter people with fragile bones, either as an isolated entity, or a co-morbidity to their underlying rheumatic illness or treatment...
September 2018: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/30288335/the-community-health-experience-model-value-generation-from-person-centered-health-transaction-network
#7
Zoltán Lantos, Judit Simon
Background: Network society is creating new opportunities for value generation in all areas of our lives: new collaborative methods and tools are increasingly available for use by closely connected individuals and organizations. The stakeholders of the health ecosystem are potential winners of this networking process as a consequence of the increase in knowledge about health value generation supported by teamwork and collaborative approaches in this field. Case Presentation: In this paper, we focus on the transactional nature of health value generation networks...
2018: Public Health Reviews
https://www.readbyqxmd.com/read/30287350/french-recommendations-for-osteoporosis-prevention-and-treatment-in-patients-with-prostate-cancer-treated-by-androgen-deprivation
#8
Karine Briot, Julien Paccou, Philippe Beuzeboc, Jacques Bonneterre, Béatrice Bouvard, Cyrille B Confavreux, Catherine Cormier, Bernard Cortet, Jean-Michel Hannoun-Lévi, Christophe Hennequin, Rose-Marie Javier, Eric Lespessailles, Didier Mayeur, Pierre Mongiat Artus, Marie-Hélène Vieillard, Françoise Debiais
Androgen-deprivation therapy (ADT) in patients with prostate cancer can be achieved surgically or chemically, notably by prescribing LHRH analogs. Major bone loss occurs rapidly in both cases, due to the decrease in testosterone levels, and can increase the fracture risk. The objective of developing these recommendations was to achieve a practical consensus among various scientific societies, based on a literature review, about osteoporosis prevention and treatment in patients on ADT. The following scientific societies contributed to the work: Société Française de Rhumatologie (SFR), Groupe de Recherche et d'Information sur les Ostéoporoses (GRIO), Groupe Européen d'Etudes des Métastases Osseuses (GEMO), Association Francophone pour les SOins de Support (AFSOS), Association Française d'Urologie (AFU), Société Française de Radiothérapie Oncologique (SFRO)...
October 1, 2018: Joint, Bone, Spine: Revue du Rhumatisme
https://www.readbyqxmd.com/read/30283610/pharmacological-and-non-pharmacological-means-for-prevention-of-fractures-among-elderly
#9
REVIEW
Auda Fares
Fractures are major cause of morbidity, mortality, and healthcare and social services expenditure in elderly. Fractures often have multifactorial etiologies and the condition emerges due to the interaction between the different predisposing and precipitating factors. One of the most common causes leading to fractures after minimal trauma in older people is osteoporosis. The objective of this article is to describe the clinical concept and summarize the evidence and to explain the future directions for research, focusing on specific issues related to prevent fracture in the elderly...
2018: International Journal of Preventive Medicine
https://www.readbyqxmd.com/read/30195707/bone-mineral-density-among-individuals-with-residual-lower-limb-weakness-after-polio
#10
Beth Grill, Pamela K Levangie, Maria Cole, Darren Rosenberg, Leah Jensen
BACKGROUND: Literature indicates that individuals with long-term residual lower extremity (LE) weakness after polio have decreased bone mineral density (BMD) deficiencies related to muscle weakness. Where weakness is asymmetrical, bone densitometry (BDt) measured only on the stronger LE may misclassify BMD. OBJECTIVE: To determine (1) whether femoral neck BMD differed from side to side in individuals with asymmetrical LE muscle weakness, and (2) the proportion of individuals at risk for underdiagnosis of low bone density or osteoporosis given unilateral assessment of the femoral neck...
September 7, 2018: PM & R: the Journal of Injury, Function, and Rehabilitation
https://www.readbyqxmd.com/read/30182268/-trochanteric-and-subtrochanteric-fractures
#11
C Bahrs, A Schreiner, U Stöckle, T Klopfer, P Hemmann
Proximal femoral fractures are one of the most common fractures, particularly in older people. The most common cause is a falling event due to dizziness and gait insecurity. In most cases prompt surgical treatment is necessary to achieve early mobilization and to reduce the risk of mortality. The aim is a stable osteosynthesis and patient-centered care. A great variety of implants are available for this purpose. Furthermore, perioperative management is important to prevent further problematic events, such as delirium, reoccurrence of falling events and to diagnose and adequately treat a pre-existing osteoporosis...
October 2018: Der Chirurg; Zeitschrift Für Alle Gebiete der Operativen Medizen
https://www.readbyqxmd.com/read/30175057/osteoporosis-and-musculoskeletal-complications-related-to-therapy-of-breast-cancer
#12
REVIEW
Johanna Suskin, Charles L Shapiro
Aromatase inhibitors (AIs) are the treatment of choice for the majority of postmenopausal women with estrogen receptor (ER) positive breast cancers in early and advanced stage settings. One of most frequent side effects of AIs is bone loss that is of sufficient magnitude to increase risk of osteoporotic fractures. Osteoporosis is primarily a complex genetic disease with few modifiable risk factors. As the lifespan increases, and breast mortality decreases, more women with breast cancer will be at risk of osteoporotic fractures, or falls that result in fractures...
August 2018: Gland Surgery
https://www.readbyqxmd.com/read/30159752/elevated-red-blood-cell-distribution-width-is-associated-with-morphometric-vertebral-fracture-in-community-dwelling-older-adults-independent-of-anemia-inflammation-and-nutritional-status-the-korean-urban-rural-elderly-kure-study
#13
Namki Hong, Chang Oh Kim, Yoosik Youm, Jin-Young Choi, Hyeon Chang Kim, Yumie Rhee
Elevated red blood cell distribution width (RDW), a simple measure of red blood cell size heterogeneity, has been associated with increased mortality and morbidity in the elderly population, which might reflect systemic inflammation and malnutrition. However, whether elevated RDW is associated with prevalent morphometric vertebral fracture (VF) in older adults has not been investigated. We examined 2127 individuals (mean age 71.7 years; women 66%) from a community-based cohort. VF was defined as ≥ 25% reduction in vertebral column height using the Genant semiquantitative method...
August 29, 2018: Calcified Tissue International
https://www.readbyqxmd.com/read/30138538/27-hydroxycholesterol-an-endogenous-serm-and-risk-of-fracture-in-postmenopausal-women-a-nested-case-cohort-study-in-the-women-s-health-initiative
#14
Po-Yin Chang, David Feldman, Marcia L Stefanick, Donald P McDonnell, Bonne M Thompson, Jeffrey G McDonald, Jennifer S Lee
27-hydroxycholesterol (27HC) is a purported, novel endogenous SERM. In animal models, 27HC has an anti-estrogen effect in bone, and 17β-estradiol mitigates this effect. 27HC in relation to fracture risk has not been investigated in humans. Depending on the level of bioavailable 17β-estradiol (bioE2), 27HC may increase fracture risk in postmenopausal women and modify the fracture risk reduction from menopausal hormone therapy (MHT). To test these a priori hypotheses, we conducted a nested case-cohort study of 868 postmenopausal women within the Women's Health Initiative Hormone Therapy trials (WHI-HT)...
August 23, 2018: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/30131112/mapping-anisotropy-improves-qct-based-finite-element-estimation-of-hip-strength-in-pooled-stance-and-side-fall-load-configurations
#15
J Panyasantisuk, E Dall'Ara, M Pretterklieber, D H Pahr, P K Zysset
Hip fractures are one of the most severe consequences of osteoporosis. Compared to the clinical standard of DXA-based aBMD at the femoral neck, QCT-based FEA delivers a better surrogate of femoral strength and gains acceptance for the calculation of hip fracture risk when a CT reconstruction is available. Isotropic, homogenised voxel-based, finite element (hvFE) models are widely used to estimate femoral strength in cross-sectional and longitudinal clinical studies. However, fabric anisotropy is a classical feature of the architecture of the proximal femur and the second determinant of the homogenised mechanical properties of trabecular bone...
September 2018: Medical Engineering & Physics
https://www.readbyqxmd.com/read/30109432/dysmobility-syndrome-is-associated-with-prevalent-morphometric-vertebral-fracture-in-older-adults-the-korean-urban-rural-elderly-kure-study
#16
Namki Hong, Chang Oh Kim, Yoosik Youm, Jin-Young Choi, Hyeon Chang Kim, Yumie Rhee
In a community-dwelling elderly cohort, dysmobility syndrome was associated with elevated odds of morphometric vertebral fracture or any prevalent fracture, independent of age and covariates. Dysmobility syndrome improved discrimination for fracture when added to the FRAX score. INTRODUCTION: Dysmobility syndrome was coined to indicate patients with impaired musculoskeletal health. Data on the association of dysmobility syndrome with prevalent morphometric vertebral fracture (VF) in elderly persons are limited...
August 14, 2018: Archives of Osteoporosis
https://www.readbyqxmd.com/read/30099717/high-prevalence-of-risk-factors-for-low-bone-mineral-density-and-estimated-fracture-and-fall-risk-among-elderly-medical-inpatients-a-missed-opportunity
#17
Muhammad Haroon, Kamil Khan, Lorraine Thong, Kabir Ali, Fayyaz Janjua
AIMS: (1) To calculate the absolute fracture risk by using the fracture risk assessment (FRAX) model among elderly medical inpatients; (2) to assess the risk of falls, especially among patients with increased risk of fractures; and (3) to design and implement a bone health protocol to improve the assessment of fracture risk. METHODS: The study participants were all inpatients admitted to the medical wards at University Hospital Kerry, Ireland. All consecutive eligible patients aged ≥ 65 years were prospectively evaluated to populate clinical risk factor variables used in the FRAX model and the fall assessment was made by using Fracture Risk Questionnaire...
August 11, 2018: Irish Journal of Medical Science
https://www.readbyqxmd.com/read/30098424/sarcopenia
#18
Anne Tournadre, Gaelle Vial, Frédéric Capel, Martin Soubrier, Yves Boirie
Sarcopenia is defined as a combination of low muscle mass with low muscle function. The term was first used to designate the loss of muscle mass and performance associated with aging. Now, recognized causes of sarcopenia also include chronic disease, a physically inactive lifestyle, loss of mobility, and malnutrition. Sarcopenia should be differentiated from cachexia, which is characterized not only by low muscle mass but also by weight loss and anorexia. Sarcopenia results from complex and interdependent pathophysiological mechanisms that include aging, physical inactivity, neuromuscular compromise, resistance to postprandial anabolism, insulin resistance, lipotoxicity, endocrine factors, oxidative stress, mitochondrial dysfunction, and inflammation...
August 8, 2018: Joint, Bone, Spine: Revue du Rhumatisme
https://www.readbyqxmd.com/read/30097246/quantitative-measurement-of-the-improvement-derived-from-a-10-mo-progressive-exercise-program-to-improve-balance-and-function-in-women-at-increased-risk-for-fragility-fractures
#19
Mark Graves, Kim Snyder, Joni McFelea, Jan Szczepanski, Mark Philip Smith, Thomas Strobel, Nona Mehrnia, Jacob Schneider, Madison J Snyder, Andrew Kilian Graves, Judith Canlas
INTRODUCTION/BACKGROUND: Osteoporosis is a common disorder and is associated with an increased risk of bone fracture. Falls are a proximate cause of a high proportion of medical costs and mortality. Improving balance can reduce the risk of falls and improve health outcomes, especially for the at-risk population of people with osteoporosis and osteopenia. The FrameWorksTM exercise program is a formal, standardized, informational and interventional 10-month exercise program. The purpose of this study was to quantitatively assess the improvement in standing balance, functional reach, and overall confidence in balance after participating in the 10-month program...
June 23, 2018: Journal of Clinical Densitometry
https://www.readbyqxmd.com/read/30091064/build-better-bones-with-exercise-b3e-pilot-trial-results-of-a-feasibility-study-of-a-multicenter-randomized-controlled-trial-of-12-months-of-home-exercise-in-older-women-with-vertebral-fracture
#20
L M Giangregorio, J C Gibbs, J A Templeton, J D Adachi, M C Ashe, R R Bleakney, A M Cheung, K D Hill, D L Kendler, A A Khan, S Kim, C McArthur, N Mittmann, A Papaioannou, S Prasad, S C Scherer, L Thabane, J D Wark
We pilot-tested a trial of home exercise on individuals with osteoporosis and spine fracture. Our target enrollment was met, though it took longer than expected. Participants stayed in the study and completed the exercise program with no safety concerns. Future trials should expand the inclusion criteria and consider other changes. PURPOSE: Osteoporotic fragility fractures create a substantial human and economic burden. There have been calls for a large randomized controlled trial examining the effect of exercise on fracture incidence...
August 8, 2018: Osteoporosis International
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