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osteoporosis fall

Muhammad Haroon, Kamil Khan, Lorraine Thong, Kabir Ali, Fayyaz Janjua
AIMS: (1) To calculate the absolute fracture risk by using the fracture risk assessment (FRAX) model among elderly medical inpatients; (2) to assess the risk of falls, especially among patients with increased risk of fractures; and (3) to design and implement a bone health protocol to improve the assessment of fracture risk. METHODS: The study participants were all inpatients admitted to the medical wards at University Hospital Kerry, Ireland. All consecutive eligible patients aged ≥ 65 years were prospectively evaluated to populate clinical risk factor variables used in the FRAX model and the fall assessment was made by using Fracture Risk Questionnaire...
August 11, 2018: Irish Journal of Medical Science
Anne Tournadre, Gaelle Vial, Frédéric Capel, Martin Soubrier, Yves Boirie
Sarcopenia is defined as a combination of low muscle mass with low muscle function. The term was first used to designate the loss of muscle mass and performance associated with aging. Now, recognized causes of sarcopenia also include chronic disease, a physically inactive lifestyle, loss of mobility, and malnutrition. Sarcopenia should be differentiated from cachexia, which is characterized not only by low muscle mass but also by weight loss and anorexia. Sarcopenia results from complex and interdependent pathophysiological mechanisms that include aging, physical inactivity, neuromuscular compromise, resistance to postprandial anabolism, insulin resistance, lipotoxicity, endocrine factors, oxidative stress, mitochondrial dysfunction, and inflammation...
August 8, 2018: Joint, Bone, Spine: Revue du Rhumatisme
Mark Graves, Kim Snyder, Joni McFelea, Jan Szczepanski, Mark Philip Smith, Thomas Strobel, Nona Mehrnia, Jacob Schneider, Madison J Snyder, Andrew Kilian Graves, Judith Canlas
INTRODUCTION/BACKGROUND: Osteoporosis is a common disorder and is associated with an increased risk of bone fracture. Falls are a proximate cause of a high proportion of medical costs and mortality. Improving balance can reduce the risk of falls and improve health outcomes, especially for the at-risk population of people with osteoporosis and osteopenia. The FrameWorksTM exercise program is a formal, standardized, informational and interventional 10-month exercise program. The purpose of this study was to quantitatively assess the improvement in standing balance, functional reach, and overall confidence in balance after participating in the 10-month program...
June 23, 2018: Journal of Clinical Densitometry
L M Giangregorio, J C Gibbs, J A Templeton, J D Adachi, M C Ashe, R R Bleakney, A M Cheung, K D Hill, D L Kendler, A A Khan, S Kim, C McArthur, N Mittmann, A Papaioannou, S Prasad, S C Scherer, L Thabane, J D Wark
We pilot-tested a trial of home exercise on individuals with osteoporosis and spine fracture. Our target enrollment was met, though it took longer than expected. Participants stayed in the study and completed the exercise program with no safety concerns. Future trials should expand the inclusion criteria and consider other changes. PURPOSE: Osteoporotic fragility fractures create a substantial human and economic burden. There have been calls for a large randomized controlled trial examining the effect of exercise on fracture incidence...
August 8, 2018: Osteoporosis International
Claire L Wood, Volker Straub
PURPOSE OF REVIEW: Muscle and bone are intrinsically linked, and therefore, it is not surprising that many muscular dystrophies are associated with impaired bone health and increased risk of osteoporosis. Osteoporotic fracture is an important and preventable cause of morbidity and mortality. This article will firstly review the general causes of impaired bone health in muscular dystrophies and then focus on the evidence available for the diagnosis and treatment of osteoporosis in specific conditions...
August 4, 2018: Current Opinion in Neurology
Norio Imai, Minako Wakasugi, Naoto Endo
Intervention of the osteoporosis liaison service for hemodialysis patients is considered essential, because hemodialysis patients are at higher risk of fracture and fall than individuals not undergoing dialysis. It may help to maintain the activity of hemodialysis patients to practice interprofessional collaboration for consistent prevention of primary fracture, thereby supporting discharge planning. We expect to organize a specialized fracture prevention team for dialysis patients to manage their anti-osteoporosis medication and nutritive support, as well as to evaluate their physical statuses and prevent falls...
2018: Clinical Calcium
Kenichi Akiyama, Norio Hanafusa
According to the current status of chronic dialysis therapy in Japan 2016, the average age at the time of dialysis initiation is 68.57 years for males and 71.19 years for females, which has been rising continuously. Frailty is a geriatric syndrome that is frequently seen in the elderly. It is known that frailty among dialysis patients are more common than the general population of the same age, and that frailty is associated with life prognosis. As eGFR decreases, BMD decreases and fracture risk increase, and dialysis patients are at the highest risk of fracture in CKD patients...
2018: Clinical Calcium
Shozo Yano
Previous studies demonstrated that patients undergoing chronic dialysis therapy showed several times higher risks for hip fracture compared to those of healthy subjects. Their bone tissue would be vulnerable because of the bone loss and poor quality. In addition, volume and strength of the muscle are decreased and the ratio of sarcopenia or frailty is increased among these patients, accordingly leading to higher risks for falls and bone fractures. Considering the pathophysiology of bone fracture in dialysis patients, it is a matter of course that one wonders how effective recently developed medicine for"classical" osteoporosis is...
2018: Clinical Calcium
David Scott, Markus Seibel, Robert Cumming, Vasi Naganathan, Fiona Blyth, David G Le Couteur, David J Handelsman, Louise M Waite, Vasant Hirani
Background: It is unclear whether older men with osteopenia/osteoporosis and sarcopenia (so called "osteosarcopenia") are at greater risk of falls and fractures than those with either condition alone. Methods: 1,575 community-dwelling men aged ≥70 years had appendicular lean mass, total hip and lumbar spine bone mineral density (BMD) determined by dual-energy X-ray absorptiometry, and completed hand grip strength and gait speed tests. Osteopenia/osteoporosis was defined as a T-score at any site ≤-1...
July 18, 2018: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
Alessandra Aldieri, Mara Terzini, Giangiacomo Osella, Adriano M Priola, Alberto Angeli, Andrea Veltri, Alberto Audenino, Cristina Bignardi
At present, the current gold-standard for osteoporosis diagnosis is based on bone mineral density measurement, which, however, has been demonstrated to poorly estimate fracture risk. Further parameters in the hands of the clinicians are represented by the Hip Structural Analysis (HSA) variables, which include geometric information of the proximal femur cross-section. The purpose of this study was to investigate the suitability of HSA parameters as additional hip fracture risk predictors. With this aim, twenty-eight three-dimensional patient-specific models of the proximal femur were built from CT images and a sideways fall condition was reproduced by finite element analyses...
June 25, 2018: Journal of Biomechanical Engineering
Yukari Uemura, Shiro Tanaka, Teruhiko Miyazaki, Mayumi Tsukiyama, Teruki Sone, Akira Taguchi, Satoshi Soen, Satoshi Mori, Hiroshi Hagino, Toshitsugu Sugimoto, Masao Fukunaga, Hiroaki Ohta, Toshitaka Nakamura, Hajime Orimo, Masataka Shiraki
We planned to conduct multi-center, open-labeled, blinded-endpoints, head-to-head randomized trial of minodronate and raloxifene to compare incidences of vertebral and non-vertebral fractures. The study is the Japanese Osteoporosis Intervention Trial protocol number 4 (JOINT-4). Here, we present the pre-fixed study design. The inclusion criteria are ambulatory older women with osteoporosis, aged > 60 years, and without pre-specified risk factors for secondary osteoporosis and dementia. The subjects who meet selection criteria will be randomly allocated to the raloxifene (60 mg/day) or minodronate (1 mg/day or 50 mg/4 weeks) groups using the central registry...
July 17, 2018: Journal of Bone and Mineral Metabolism
Ayse Zengin, Louise J Maple-Brown, Sharon Brennan-Olsen, Jacqueline R Center, Sandra Eades, Peter R Ebeling
INTRODUCTION: Research on non-communicable diseases (NCD) in Indigenous Australians has mostly focused on diabetes mellitus and chronic kidney or cardiovascular disease. Osteoporosis, characterised by low bone mass and structural deterioration of bone tissue, and sarcopenia, the age-related loss of muscle mass and strength, often co-exist with these common NCDs-the combination of which will disproportionately increase bone fragility and fracture risk and negatively influence cortical and trabecular bone...
July 14, 2018: Archives of Osteoporosis
Lia Mara Montagner Rossi, Rafaela Martinez Copes, Leo Canterle Dal Osto, Clovis Flores, Fábio Vasconcellos Comim, Melissa Orlandin Premaor
Although fractures had high mortality and morbidity, many studies proved that fracture risk might be decreased by pharmacological therapy, although a low treatment adherence rate is observed. The aim of this study was to identify factors associated with osteoporosis treatment in postmenopausal women.A cross-sectional study was carried out from March to August 2013 at the primary care setting. Postmenopausal women were recruited. A standardized questionnaire was applied. Women who were using at least one of the following drugs at the moment of the survey were considered as current treatment: bisphosphonates, raloxifene, estrogen, calcitonin, teriparatide, or strontium ranelate...
July 2018: Medicine (Baltimore)
Mohammad Davood Sharifi, Masoud Mohebbi, Mahmood Farrokhfar, Roohie Farzaneh, Hamideh Feiz Disfani, Amir Masoud Hashemian
Osteoporosis is a major public health challenge all over the world. Estrogen hormone was cited amongst other hormones to be an efficient hormone for the production and maintenance of bone density. This study was designed with the purpose of evaluating and analyzing the estradiol effect on fractures of femur neck in the Iranian society. This study evaluated men over 50 years of age suffering with mild trauma (falling off the same level height or lower) and with a fracture on their femur neck. Also, their serum level of estradiol was measured with an ELISA method...
April 24, 2018: European Journal of Translational Myology
Paul Dimitri
The risk of fracture secondary to low-impact trauma is greater in obese children, suggesting obese children are at risk of skeletal fragility. However, despite this finding, there is a lack of agreement about the impact of excessive adiposity on skeletal development. The combination of poor diet, sedentary lifestyle, greater force generated on impact through falls, and greater propensity to falls may in part explain the increased risk of fracture in obese children. To date, evidence suggests that in early childhood years, obesity confers a structural advantage to the developing skeleton...
June 2018: Annals of Pediatric Endocrinology & Metabolism
Atsushi Suzuki
Nutritional guidance and exercise should be beneficial as well as pharmacotherapy in life style-related diseases including diabetes and osteoporosis. Sufficient and appropriate energy intake with protein, calcium and vitamin D is good for bone and muscles in osteoporotic patient. Diabetes patients are often recommended to reduce body weight. However, losing weight could be related to bone loss. Therefore, we should pay attention to keep balance between glucose metabolism and bone metabolism in the patients with both diseases...
2018: Clinical Calcium
N Stolzenberg, D Felsenberg, D L Belavy
Older women with low bone mass are at higher risk of fracture and there is limited data on what is associated with risk of falls. We found explosive jumping to relate most strongly to postural control. It may be beneficial to include power or speed training into falls prevention programs. INTRODUCTION: Post-menopausal women with low bone mass are at higher risk of bone fractures subsequent to falls. Understanding the correlates of postural control in this collective informs intervention design for falls prevention...
June 25, 2018: Osteoporosis International
Ali Dostanpor, Catherine A Dobson, Natalie Vanicek
BACKGROUND: The gait patterns of women with low bone mineral density (BMD) or osteoporosis have not been thoroughly explored, and when examined, often studied in relation to falls and kyphosis. RESEARCH QUESTION: The aim of this study was to investigate the relationships between gait parameters and comfortable, self-selected walking speed and BMD in older post-menopausal women with a broad range of T-scores (healthy to osteoporotic). METHODS: 3D kinematic and kinetic data were collected from forty-five women mean (SD) age 67...
June 20, 2018: Gait & Posture
Jason A Horowitz, Varun Puvanesarajah, Amit Jain, Michael Raad, Joseph P Gjolaj, Francis H Shen, Hamid Hassanzadeh
STUDY DESIGN: Retrospective Review. OBJECTIVE: To identify and compare the incidences of fragility fractures amongst three elderly populations: the general population, patients with surgically treated cervical spondylotic myelopathy (CSM), and patients with CSM not surgically treated. SUMMARY OF BACKGROUND DATA: CSM is a common disease in the elderly. Progression of myelopathic symptoms, including gait imbalance, can be a source of morbidity as it can lead to increased falls...
June 22, 2018: Spine
Andrew D Ablett, Adrian D Wood, Rebecca Barr, Jordan Guillot, Alison J Black, Helen M Macdonald, David M Reid, Phyo K Myint
PURPOSE: To examine the cross-sectional association between anticholinergic medication burden (ACB) and a history of falls, bone mineral density, and low trauma fractures in middle-aged women aged under 65 years from the Aberdeen Prospective Osteoporosis Screening Study. METHODS: ACB (0 = none, 1 = possible, ≥2 = definite) was calculated from medication use for 3883 Caucasian women [mean age (SD) = 54.3 (2.3) years] attending the second Aberdeen Prospective Osteoporosis Screening Study visit (1997-2000)...
August 2018: Annals of Epidemiology
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