Ziteng Liang, Jincheng Tong, Ziqi Sun, Shuo Liu, Jiajing Wu, Xi Wu, Tao Li, Yuanling Yu, Li Zhang, Chenyan Zhao, Qiong Lu, Jianhui Nie, Weijin Huang, Youchun Wang
SARS-CoV-2 breakthrough infections in vaccinated individuals underscore the threat posed by continuous mutating variants, such as Omicron, to vaccine-induced immunity. This necessitates the search for broad-spectrum immunogens capable of countering infections from such variants. This study evaluates the immunogenicity relationship among SARS-CoV-2 variants, from D614G to XBB, through Guinea pig vaccination, covering D614G, Alpha, Beta, Gamma, Delta, BA.1, BA.2, BA.2.75, BA.2.75.2, BA.5, BF.7, BQ.1.1, and XBB, employing three immunization strategies: three-dose monovalent immunogens, three-dose bivalent immunogens, and a two-dose vaccination with D614G followed by a booster immunization with a variant strain immunogen...
January 2024: Journal of Medical Virology