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Nandita M deSouza, Clare M Tempany
Recognition of < 3 metastases in < 2 organs, particularly in cancers with a known predisposition to oligometastatic disease (OMD) (colorectal, prostate, renal, sarcoma and lung), offers the opportunity to focally treat the lesions identified and confers a survival advantage. The reliability with which OMD is identified depends on the sensitivity of the imaging technique used for detection and may be predicted from phenotypic and genetic factors of the primary tumour, which determine metastatic risk. Whole-body or organ-specific imaging to identify oligometastases requires optimization to achieve maximal sensitivity...
August 11, 2018: International Journal of Cancer. Journal International du Cancer
Sarah B Rockswold, Phillip C Burton, Amy Chang, Nova McNally, Andrea Grant, Gaylan Rockswold, Walter C Low, Lynn Eberly, Essa Yacoub, Christophe Lenglet
Mild traumatic brain injury (mTBI) is a significant cause of disability, especially when symptoms become chronic. This chronicity is often linked to oculomotor dysfunction (OMD).1,2 To our knowledge, this is the first prospective study to localize aberrations in brain function between mTBI cohorts, by comparing mTBI patients with OMD to an mTBI control group without OMD, using task and resting-state functional magnetic resonance imaging (fMRI). Ten mTBI subjects who had OMD (OMD group) were compared to nine mTBI subjects who had no findings of OMD (control group)...
July 17, 2018: Journal of Neurotrauma
Ryo Iwamura, Masayuki Tanaka, Eiji Okanari, Tomoko Kirihara, Noriko Odani-Kawabata, Naveed Shams, Kenji Yoneda
EP2 receptor agonists are expected to be effective ocular hypotensive agents; however, it has been suggested that agonism to other EP receptor subtypes may lead to undesirable effects. Through medicinal chemistry efforts, we identified a scaffold bearing a (pyridin-2-ylamino)acetic acid moiety as a promising EP2-selective receptor agonist. (6-((4-(Pyrazol-1-yl)benzyl)(pyridin-3-ylsulfonyl)aminomethyl)pyridin-2-ylamino)acetic acid 13ax (omidenepag, OMD) exerted potent and selective activity toward the human EP2 receptor (h-EP2)...
July 30, 2018: Journal of Medicinal Chemistry
Frank Schneider, Lavi Erisson, Hooman Beygi, Margaret Bradbury, Orit Cohen-Barak, Igor D Grachev, Serge Guzy, Pippa S Loupe, Micha Levi, Mirna McDonald, Juha-Matti Savola, Spyros Papapetropoulos, William G Tracewell, Maria Velinova, Ofer Spiegelstein
AIM: SD-1077, a selectively deuterated precursor of dopamine (DA) structurally related to L-3,4-dihydroxyphenylalanine (L-DOPA), is under development for treatment of motor symptoms of Parkinson's disease. Preclinical models have shown slower metabolism of central deuterated DA. The present study investigated the peripheral pharmacokinetics (PK), metabolism and safety of SD-1077. METHODS: Plasma and urine PK of drug and metabolites and safety after a single oral 150 mg SD-1077 dose were compared to 150 mg L-DOPA, each in combination with 37...
June 29, 2018: British Journal of Clinical Pharmacology
M Abbasi, Y Rouzbehan, J Rezaei, S E Jacobsen
This study assessed the influence of wilting, lactobacillus (LAB) and / or molasses on the chemical composition, phenolic compounds, in situ degradability and in vitro ruminal fermentation parameters of amaranth (var. Maria) silage using a randomized complete block design with 6 replicates. Treatments were fresh amaranth forage (FAF), ensiled amaranth without additive (EA), EA inoculated with LAB (EAB), EA + 5% of molasses (EAM), EA inoculated with LAB + 5% of molasses (EABM) and 24-h wilted EA (WEA). The ensiled materials were stored anaerobically for a period of 45 d...
June 25, 2018: Journal of Animal Science
Linda Slaim, Myriam Cohen, Patrick Klap, Marie Vidailhet, Alain Perrin, Daniel Brasnu, Denis Ayache, Marie Mailly
OBJECTIVE: To report demographic data from a large cohort of patients with oromandibular dystonia (OMD). METHODS: This is a retrospective review of patients with OMD referred to our institution between 1989 and 2015. Demographic (age of onset, gender, and familial history of dystonia) and clinical (type of OMD, associated dystonia, and etiology of dystonia) data were collected from a cohort of 240 individuals. RESULTS: The mean age of onset of OMD was 51...
May 2018: Journal of Movement Disorders
Letizia Scarponi, Claudia Maria de Felicio, Chiarella Sforza, Claudia Lucia Pimenta Ferreira, Daniela Ginocchio, Nicole Pizzorni, Stefania Barozzi, Francesco Mozzanica, Antonio Schindler
OBJECTIVE: To evaluate the reliability, validity, and responsiveness of the Italian OMES (I-OMES). PATIENTS AND METHODS: The study consisted of 3 phases: (1) internal consistency and reliability, (2) validity, and (3) responsiveness analysis. The recruited population included 27 patients with orofacial myofunctional disorders (OMD) and 174 healthy volunteers. Forty-seven subjects, 18 healthy and all recruited patients with OMD were assessed for inter-rater and test-retest reliability analysis...
2018: Folia Phoniatrica et Logopaedica
Umberto Raucci, Pasquale Parisi, Nicola Vanacore, Valentina Ferro, Giacomo Garone, Federica Sancetta, Sergio Petroni, Stefano Pro, Rossella Rossi, Antonino Reale, Nicola Pirozzi
BACKGROUND: Acute ocular motility disorders (OMDs) in children admitted to Emergency Department (ED) represents a not so rare condition with a wide spectrum of different etiologies. The emergency physician must be skilled in rapidly identifying patients with potentially life threatening (LT) forms, requiring further diagnostic procedures. The aim of the study was to assess characteristics of children with acute Ocular Motility Disorders (OMDs), and to identify "red flags" for recognition of underlying life-threatening (LT) conditions...
May 29, 2018: Italian Journal of Pediatrics
Shinpei Matsuda, Hitoshi Yoshimura, Kazuo Sano
Dystonia affecting the perioral and pharyngeal regions is called oromandibular dystonia (OMD). OMD can affect the jaw muscles and may cause trismus, mouth-closing disturbance, tooth wear/loss, and damage to the oral soft tissues and temporomandibular joint (TMJ). This case history reports a case of jaw-closing OMD accompanied by trismus-related TMJ osteoarthritis (OA). In the present case history, treatment for OMD was started as soon as the diagnosis of jaw-closing OMD was established, and dental treatment intervention for preventing its development or progression was considered at the same time...
May 2018: International Journal of Prosthodontics
Marie Christou-Kent, Zine-Eddine Kherraf, Amir Amiri-Yekta, Emilie Le Blévec, Thomas Karaouzène, Béatrice Conne, Jessica Escoffier, Said Assou, Audrey Guttin, Emeline Lambert, Guillaume Martinez, Magalie Boguenet, Selima Fourati Ben Mustapha, Isabelle Cedrin Durnerin, Lazhar Halouani, Ouafi Marrakchi, Mounir Makni, Habib Latrous, Mahmoud Kharouf, Charles Coutton, Nicolas Thierry-Mieg, Serge Nef, Serge P Bottari, Raoudha Zouari, Jean Paul Issartel, Pierre F Ray, Christophe Arnoult
The genetic causes of oocyte meiotic deficiency (OMD), a form of primary infertility characterised by the production of immature oocytes, remain largely unexplored. Using whole exome sequencing, we found that 26% of a cohort of 23 subjects with OMD harboured the same homozygous nonsense pathogenic mutation in PATL2 , a gene encoding a putative RNA-binding protein. Using Patl2 knockout mice, we confirmed that PATL2 deficiency disturbs oocyte maturation, since oocytes and zygotes exhibit morphological and developmental defects, respectively...
May 2018: EMBO Molecular Medicine
N Musco, S Calabrò, F Roberti, R Grazioli, R Tudisco, P Lombardi, M I Cutrignelli
Six Saccharomyces cerevisiae cell wall samples were tested by the in vitro gas production technique using dog faeces as inoculum. In particular, the substrates resulted from three different production processes (alcoholic_A, bakers_BA and brewers_BR) and were characterized by two different carbohydrates (mannans + glucans) concentrations nitrogen-free extract (NFE high and low). Gas production of fermenting cultures was recorded for 72 hr to estimate the fermentation profiles. The organic matter degradability (OMD), fermentation liquor pH, short-chain fatty acids (SCFA) and ammonia (NH3 ) productions were also measured...
April 2018: Journal of Animal Physiology and Animal Nutrition
Laura M Scorr, Michael R Silver, John Hanfelt, Elaine Sperin, Alan Freeman, H A Jinnah, Stewart A Factor
Oromandibular dystonia (OMD) causes involuntary movements of masticatory and lingual muscles impairing eating, speaking, and swallowing. Treatment options are limited. The objective of this study was to determine the safety and efficacy of abobotulinumtoxinA (aboBoNTA) in OMD. A dose-finding study (phase 1) followed by a single session, prospective, single-blind trial (phase 2) was carried out. OMD subjects were evaluated at baseline, 6 and 12 weeks. Muscles injected were tailored to individual symptoms using EMG guidance, but the aboBoNTA dose for each muscle was pre-specified based on phase 1 results...
April 2018: Neurotherapeutics: the Journal of the American Society for Experimental NeuroTherapeutics
F J W C Schaafstra, D A van Doorn, J T Schonewille, E Roelfsema, C M Westermann, O Dansen, M Jacobs, J-Y Lee, E A Spronck, M C Blok, W H Hendriks
Exercise and physical training are known to affect gastrointestinal function and digestibility in horses and can lead to inaccurate estimates of nutrient and energy digestibility when markers are used. The effect of exercise on apparent nutrient digestibility and faecal recoveries of ADL and TiO2 was studied in six Welsh pony geldings subjected to either a low- (LI) or high-intensity (HI) exercise regime according to a cross-over design. Ponies performing LI exercise were walked once per day for 45 min in a horse walker (5 km/h) for 47 consecutive days...
March 7, 2018: Animal: An International Journal of Animal Bioscience
O P Shmakova, N A Mazaeva
AIM: To analyze the clinical and social outcomes of organic mental disorders (OMD), diagnosed in children and teens; establish the factors that are relevant for the formation of the clinical picture of OMD in different sexes; the circumstances that determine the dynamics of remote OMD and the level of social adaptation of patients in adulthood. MATERIAL AND METHODS: Four hundred and ninety-eight children with organic mental disorders were followed-up in one of neuropsychiatric outpatient clinics of Moscow, until they reached 23-25 years of age...
2018: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
Cynthia L Comella
Oromandibular dystonia (OMD) is an isolated focal dystonia that affects the muscles of the jaw, lower face and tongue. It is a rare disorder but is associated with significant impairment in quality of life. Treatment with oral medications has not been successful. Surgical interventions, such as deep brain stimulation, may be of benefit but have not been adequately evaluated. Currently, botulinum toxin (BoNT) injections are regarded as the treatment of choice for OMD. However, the evidence supporting this is not available...
June 1, 2018: Toxicon: Official Journal of the International Society on Toxinology
Olcay Sakar, Zeliha Matur, Zeynep Mumcu, Pinar Sesen, Emre Oge
Oromandibular dystonia (OMD) is defined as a subset of movement disorders characterized by involuntary muscle contraction in different parts of the oromandibular region. This clinical report presents a multidisciplinary approach to the management of a patient with OMD. The involuntary movement of her mandible and tongue was improved with a mandibular custom occlusal splint and maxillary modified removable complete denture together with botulinum toxin A injections.
February 8, 2018: Journal of Prosthetic Dentistry
Laura Evangelista, Lea Cuppari, Andrea Guttilla, Mario Gardi, Andrea Agostini, Lorenzo Ruggera, Umberto Basso, Giorgio Saladini
PURPOSE: The aim of this study was to assess the ability of fluorine-18-fluorocholine (F-FCH) PET/computed tomography (CT) to detect oligometastatic disease (OMD) in patients with early recurrence of prostate cancer (PC) [prostate-specific antigen (PSA)≤5 ng/ml]. PATIENTS AND METHODS: Between 2010 and 2016, 324 patients with PC and PSA levels of less than or equal to 5 ng/ml were recruited. The mean (SD) age of the patients was 71 (10) years. All patients were treated with a radical prostatectomy±lymphadenectomy...
March 2018: Nuclear Medicine Communications
Sarah M Lyon, Anoop Mayampurath, Dongzhe Song, Jixing Ye, Michael Januszyk, M Rose Rogers, Ashley Ralston, David M Frim, Tong-Chuan He, Russell R Reid
BACKGROUND: The pathophysiology of nonsyndromic craniosynostosis remains poorly understood. The authors seek to understand the cause of this condition with a specific focus on how osteoclasts may contribute to craniosynostosis. Here, the authors characterize proteins differentially expressed in patent and fused cranial sutures by comparing their respective proteomes. METHODS: Fused and patent suture samples were obtained from craniosynostotic patients undergoing surgery at a single academic medical center...
February 2018: Plastic and Reconstructive Surgery
Tomoko Kirihara, Takazumi Taniguchi, Kenzo Yamamura, Ryo Iwamura, Kenji Yoneda, Noriko Odani-Kawabata, Atsushi Shimazaki, Takeshi Matsugi, Naveed Shams, Jin-Zhong Zhang
Purpose: The objective of this study was to investigate the pharmacologic characteristics of omidenepag isopropyl (OMDI), a compound developed as a novel intraocular pressure (IOP)-lowering agent, with better IOP control and fewer side effects than other prostanoid receptor agonists such as prostaglandin F receptor (FP) agonists. Methods: Binding activities of OMDI and its hydrolyzed form, omidenepag (OMD), to human recombinant prostanoid receptors (DP1-2, EP1-4, FP, and IP) were evaluated...
January 1, 2018: Investigative Ophthalmology & Visual Science
Nandita M deSouza, Yan Liu, Arturo Chiti, Daniela Oprea-Lager, Géraldine Gebhart, Bernard E Van Beers, Ken Herrmann, Frederic E Lecouvet
Patients with oligometastatic disease (OMD) often have controllable symptoms, and cures are possible. Technical improvements in surgery and radiotherapy have introduced the option of metastasis-directed ablative therapies as an adjunct or alternative to standard-of-care systemic therapies. Several clinical trials and registries are investigating the benefit of these therapeutic approaches across several cancer sites. This requires that patients are correctly included and followed with appropriate imaging. This article discusses the evidence and offers recommendations for the implementation of standard-of-care (Response Evaluation Criteria in Solid Tumours measurements on computed tomography [CT], magnetic resonance imaging [MRI] and bone scintigraphy) and advanced imaging modalities (functional, metabolic and radionuclide targeted) for identifying and following up patients with OMD...
March 2018: European Journal of Cancer
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