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JOURNAL ARTICLE
F E García-Dobarganes-Barlow, J M Valadez-Soto, N Saavedra-Islas, V M García-Romo, J Mata-Coronado, E Villavicencio-Ocampo, M I Encalada-Díaz
Long COVID is a term used to describe the long-terms effects of COVID-19 infection that continue for weeks or months after the patient has recovered from COVID-19. Long COVID is defined by the persistence of symptoms beyond 12 weeks from the onset of the disease. Corticosteroids are part of the treatment in this period with good results in controlling the disease; however, it is a predisposing factor for the development of avascular necrosis. We present a clinic case of a young man of 39 years old with diagnosis of avascular necrosis in his left hip, before the administration of corticosteroids for the treatment of COVID-19...
2024: Acta Ortopédica Mexicana
#2
JOURNAL ARTICLE
Diana M Achury-Saldaña, Rafael A Gonzalez, Angel Garcia, Alejandro Mariño, Wilson R Bohorquez
Episodes of decompensation are the main cause of hospital admissions in patients with heart failure. For this reason, the use of mobile apps emerges as an excellent strategy to improve coverage, real-time monitoring, and timeliness of care. ControlVit is an electronic application for early detection of complications studied within the context of a tertiary university hospital. Patients were randomized to the use of ControlVit versus placebo, during a 6-month follow-up. The primary outcome was the difference in numbers of readmissions and deaths for heart failure between both groups...
April 24, 2024: Computers, Informatics, Nursing: CIN
#3
JOURNAL ARTICLE
Abeer F Almarzouki
BACKGROUND: Optimal cognitive functions, including working memory (WM), are crucial to enable trainee physicians to perform and excel in their clinical practice. Several risk factors, including on-call shifts, poor mental health, burnout, and sleep problems, can impair clinical practice in trainee physicians, potentially through cognitive impairment; however, these associations have not been fully explored. OBJECTIVE: This study investigated the effect of on-call shifts on WM among trainee physicians and its association with burnout, depression, anxiety, affect, and sleep...
April 24, 2024: Postgraduate Medicine
#4
JOURNAL ARTICLE
Kei Ito, Naoko Honma, Hideaki Ogata, Akimitsu Yamada, Mika Miyashita, Tomio Arai, Eiichi Sasaki, Kazutoshi Shibuya, Tetuo Mikami, Masataka Sawaki
Appropriate biomarkers are required to predict the clinical outcome of triple-negative breast cancer (TNBC). In this study, we focused on the clinical importance of two representative tumor-associated proteins, Bcl-2 and p53. Bcl-2 expression is usually related to estrogen receptor expression and a favorable outcome in breast cancer. TNBC has been reported to show a high frequency of p53 positivity suggesting TP53 mutations. The expressions of Bcl-2 and p53 were immunohistochemically examined in TNBC involving two age groups of postmenopausal women (≥75 y/o, n = 75; 55-64 y/o, n = 47), who underwent surgery without neoadjuvant therapy...
April 24, 2024: Pathology International
#5
COMPARATIVE STUDY
Abdo Ahmed Saleh Mohamed, Lianxi Mai, Mubarak Ahmed Mashrah, Song Fan, Shuang Wang, Zhaoyu Lin, Chaobin Pan
OBJECTIVE: Radial Forearm Free flap (RFFF) is widely used in head and neck reconstruction, yet its donor site defect remains a significant drawback. The Medial Sural Artery Perforator Free Flap (MSAPFF) is considered an alternative flap to RFFF. This study aims to comprehensively analyze their characteristics, outcomes, and their impact on patient quality of life. METHODS: All patients who underwent oral cavity reconstruction using RFFF and MSAPFF between February 2017 and April 2023 were included in this study...
April 24, 2024: Clinical Oral Investigations
#6
JOURNAL ARTICLE
Akiyoshi Shimatani, Hirohisa Katagiri, Hideki Murata, Junji Wasa, Michihito Miyagi, Yosuke Honda, Mitsuru Takahashi, Hiroyuki Harada, Hirofumi Asakura, Tsuyoshi Onoe
BACKGROUND AND PURPOSE: Because myxoid liposarcomas are more radiosensitive than other soft tissue sarcomas, there have been several reports of 50 Gy preoperative radiation therapy combined with surgery, but the wound complication rate is reportedly high. We have performed preoperative irradiation at a reduced dose of 40 Gy and definitive radiation therapy for unresectable cases. This study aimed to report the tumor reduction rate and oncological results with a reduced dose of preoperative irradiation and the outcome of definitive irradiation for unresectable cases...
April 24, 2024: International Journal of Clinical Oncology
#7
JOURNAL ARTICLE
Sanne Ahles, Peter J Joris, Jogchum Plat
PURPOSE: Evidence on the potential beneficial effects of anthocyanin-rich foods and supplements on cognitive performance is mainly based on acute or long-term studies in older adults. However, short-term studies focusing on a younger population are lacking. Therefore, short-term effects of Aronia melanocarpa extract (AME) supplementation on cognitive performance were investigated in healthy young adults. Potential underlying mechanisms were also addressed. METHODS: A randomized, double-blind, placebo-controlled cross-over study was performed involving 35 apparently healthy young adults...
April 24, 2024: European Journal of Nutrition
#8
JOURNAL ARTICLE
Wenjing Sun, Xin You, Xinjia Zhao, Xiaoyu Zhang, Chunhui Yang, Fusheng Zhang, Jiaqi Yu, Kaiguang Yang, Jixia Wang, Fangfang Xu, Yongxin Chang, Boxin Qu, Xinmiao Zhao, Yuxuan He, Qi Wang, Jinghua Chen, Guangyan Qing
Circulating tumor cells (CTCs) detection presents significant advantages in diagnosing liver cancer due to its non-invasiveness, real-time monitoring, and dynamic tracking. However, the clinical application of CTCs-based diagnosis is largely limited by the challenges of capturing low-abundance CTCs within a complex blood environment while ensuring them alive. Here we design an ultra-strong ligand, L-histidine-L-histidine (HH), specifically targeting sialylated glycans on the surface of CTCs. Further HH is integrated into a cell-imprinted polymer, constructing a hydrogel with precise CTCs imprinting, high elasticity, satisfactory blood-compatibility, and robust anti-interference capacities...
April 24, 2024: Advanced Materials
#9
JOURNAL ARTICLE
Gomathi Sivakumar, Ajay Gupta, Anashwara Babu, Pijus K Sasmal, Samarendra Maji
We have developed a highly sensitive and reliable fluorescence resonance energy transfer (FRET) probe using nitro-dopamine (ND) and dopamine (DA) coated MnO2 nanosheet (ND@MnO2 NS and DA@MnO2 NS) as an energy acceptor and MoS2 quantum dots (QDs) as an energy donor. By employing surface-modified MnO2 NS, we can effectively reduce the fluorescence intensity of MoS2 QDs through FRET. It can reduce MnO2 NS to Mn2+ and facilitate the fluorescence recovery of the MoS2 QDs. This ND@MnO2 NS@MoS2 QD-based nanoprobe demonstrates excellent sensitivity to GSH, achieving an LOD of 22...
April 24, 2024: Journal of Materials Chemistry. B, Materials for Biology and Medicine
#10
JOURNAL ARTICLE
Cecilia Magnusson, Per Augustsson, Eva Undvall Anand, Andreas Lenshof, Andreas Josefsson, Karin Welén, Anders Bjartell, Yvonne Ceder, Hans Lilja, Thomas Laurell
BACKGROUND: There are important unmet clinical needs to develop cell enrichment technologies to enable unbiased label-free isolation of both single cell and clusters of circulating tumor cells (CTCs) manifesting heterogeneous lineage specificity. Here, we report a pilot study based on the microfluidic acoustophoresis enrichment of CTCs using the CellSearch CTC assay as a reference modality. METHODS: Acoustophoresis uses an ultrasonic standing wave field to separate cells based on biomechanical properties (size, density, and compressibility), resulting in inherently label-free and epitope-independent cell enrichment...
April 24, 2024: Analytical Chemistry
#11
JOURNAL ARTICLE
John G Galbraith, Martin S Davey, Ewan Bigsby, Khalid D Mohammed, Alex A Malone
BACKGROUND: The primary aim of this study was to assess the long-term patient reported outcomes of arthroscopic rotator cuff tear (ARCR) using a single anchor tension band (TB) technique for small and medium supraspinatus tears at minimum 5-years follow-up. METHODS: A retrospective cohort study of consecutive ARCRs of small and medium supraspinatus tears using a knotless single anchor TB technique with minimum 5-year follow-up was carried out. Outcomes of interest included: range of motion (ROM) on examination under anaesthesia (EUA), visual analogue scale (VAS), American Shoulder and Elbow Surgeons (ASES) scores, Oxford Shoulder Score (OSS) and Short-Form (SF-12)...
April 2024: Shoulder & Elbow
#12
JOURNAL ARTICLE
Rui Qian, Jiamei Zhuang, Jianjun Xie, Honghui Cheng, Haiya Ou, Xiang Lu, Zichen Ouyang
BACKGROUND: Predicting the severity of acute pancreatitis (AP) early poses a challenge in clinical practice. While there are well-established clinical scoring tools, their actual predictive performance remains uncertain. Various studies have explored the application of machine-learning methods for early AP prediction. However, a more comprehensive evidence-based assessment is needed to determine their predictive accuracy. Hence, this systematic review and meta-analysis aimed to evaluate the predictive accuracy of machine learning in assessing the severity of AP...
April 30, 2024: Heliyon
#13
REVIEW
Yanxiao Fan, Miaomiao Wang, Qing Zhang, Shuqi Ouyang, Wenhui Mao, Congli Xu, Min Wang, Chunlin Long
Cynoglossum amabile, a member of the Boraginaceae family, is a well-known traditional Chinese medicine and ethnomedicine known as Daotihu. Despite several studies confirming the presence of bioactive pyrrolizidine alkaloids such as amabiline, ambelline, echinatine, europine, and others in C. amabile , there has been no comprehensive review of its traditional uses, phytochemistry, and pharmacology thus far. This review was conducted by thoroughly examining the literature and analyzing network databases. It covers various aspects of C...
2024: Frontiers in Pharmacology
#14
JOURNAL ARTICLE
Patrick Weber, Maryam Asadikorayem, František Surman, Marcy Zenobi-Wong
Improving the pharmacokinetics of intra-articularly injected therapeutics is a major challenge in treating joint disease. Small molecules and biologics are often cleared from the joint within hours, which greatly reduces their therapeutic efficacy. Furthermore, they are often injected at high doses, which can lead to local cytotoxicity and systemic side effects. In this study, we present modular polymer-drug conjugates of zwitterionic poly(carboxybetaine acrylamide) (pCBAA) and the anti-inflammatory glucocorticoid dexamethasone (DEX) to create cartilage-targeted carriers with slow-release kinetics...
June 2024: Materials today. Bio
#15
JOURNAL ARTICLE
Nuno Nascimento, Roula Kotsifaki, Emmanouil Papakostas, Bashir A Zikria, Khalid Alkhelaifi, Elisabet Hagert, Bruno Olory, Pieter D'Hooghe, Rod Whiteley
BACKGROUND: Anterior cruciate ligament (ACL) injuries are commonly assessed using clinical examination and magnetic resonance imaging, but these methods have limitations in reproducibility and quantification. Instrumented laxity measurements using devices, like the DYNEELAX®, offer an alternative approach. However, to date, there is no human data on the DYNEELAX® and the reliability of these devices remains a subject of debate, and there is no consensus on appropriate knee tightening levels for testing...
2024: Translational sports medicine
#16
JOURNAL ARTICLE
Wenjie Wang, Zijian Wang, Zumin Chen, Manman Liang, Aiping Zhang, Haoyu Sheng, Mingyue Ni, Jianghua Yang
Severe fever with thrombocytopenia syndrome (SFTS) is an emerging infectious disease with a high mortality rate. Differentiating between SFTS and hemorrhagic fever with renal syndrome (HFRS) is difficult and inefficient. Retrospective analysis of the medical records of individuals with SFTS and HFRS was performed. Clinical and laboratory data were compared, and a diagnostic model was developed based on multivariate logistic regression analyzes. Receiver operating characteristic curve analysis was used to evaluate the diagnostic model...
May 2024: Journal of Medical Virology
#17
JOURNAL ARTICLE
Hannah Baumeister, Jacob W Vogel, Philip S Insel, Luca Kleineidam, Steffen Wolfsgruber, Melina Stark, Helena M Gellersen, Renat Yakupov, Matthias C Schmid, Falk Lüsebrink, Frederic Brosseron, Gabriel Ziegler, Silka D Freiesleben, Lukas Preis, Luisa-Sophie Schneider, Eike J Spruth, Slawek Altenstein, Andrea Lohse, Klaus Fliessbach, Ina R Vogt, Claudia Bartels, Björn H Schott, Ayda Rostamzadeh, Wenzel Glanz, Enise I Incesoy, Michaela Butryn, Daniel Janowitz, Boris-Stephan Rauchmann, Ingo Kilimann, Doreen Goerss, Matthias H Munk, Stefan Hetzer, Peter Dechent, Michael Ewers, Klaus Scheffler, Anika Wuestefeld, Olof Strandberg, Danielle van Westen, Niklas Mattsson-Carlgren, Shorena Janelidze, Erik Stomrud, Sebastian Palmqvist, Annika Spottke, Christoph Laske, Stefan Teipel, Robert Perneczky, Katharina Buerger, Anja Schneider, Josef Priller, Oliver Peters, Alfredo Ramirez, Jens Wiltfang, Michael T Heneka, Michael Wagner, Emrah Düzel, Frank Jessen, Oskar Hansson, David Berron
Memory clinic patients are a heterogeneous population representing various aetiologies of pathological aging. It is unknown if divergent spatiotemporal progression patterns of brain atrophy, as previously described in Alzheimer's disease (AD) patients, are prevalent and clinically meaningful in this group of older adults. To uncover distinct atrophy subtypes, we applied the Subtype and Stage Inference (SuStaIn) algorithm to baseline structural MRI data from 813 participants enrolled in the DELCODE cohort (mean ± SD age = 70...
April 24, 2024: Brain
#18
JOURNAL ARTICLE
Rebecca Roberts, Reena Vohora, Sam S Webb, Nele Demeyere
This research aimed to determine the sensitivity and clinical validity of the OCS-Plus, a stroke-specific tablet-based cognitive screening tool, in comparison with the MoCA, a routinely used screening tool, after stroke. Eighty-six patients were recruited from Oxfordshire stroke wards over a 22-month period and completed both screens. Overall, we found that the OCS-Plus has good convergent validity and excellent sensitivity when compared with the MoCA. The OCS-Plus is therefore of potential benefit to those seeking a sensitive screening tool...
April 23, 2024: Journal of Neuropsychology
#19
JOURNAL ARTICLE
Lu Mao, Kun Wang, Weiye Zhu, Zi-Cong Shen, Xian-Jun Zhang, Zhi-Yang Xie, Pan Fan, Hang Shi, Bin Zhu, Lijun Li, Guanyi Liu, Yingqing Ren, Xiao-Tao Wu
OBJECTIVE: The reported date in the repeat surgical intervention for adolescent lumbar disc herniation (ALDH) after percutaneous endoscopic lumbar discectomy (PELD) was quite scarce. This study aims to introduce cases of repeat surgeries after PELD for ALDH and assess the incidence, chief causes, repeat surgery methods, and surgical outcomes of repeat surgeries after PELD for ALDH. METHODS: A retrospective multicenter observational study was conducted on patients undergoing repeat surgeries after PELD for ALDH at four tertiary referral hospitals from January 2014 through August 2022...
April 23, 2024: Orthopaedic Surgery
#20
JOURNAL ARTICLE
Abdulsamet Emet, Enejd Veizi, Yavuz Karaman, Erkan Akgun, Tolga Tolunay, Ahmet Firat
BACKGROUND: The precise influence of plate position on clinical outcomes in the context of volar fixed-angle plating for distal radius fractures is not fully understood. This article aims to investigate the influence of plate position on clinical results, and functional outcomes in patients treated with volar fixed plating for distal radius fractures. METHODS: A total of 58 patients with 64 distal radius fractures were included in the study. Patient demographics, fracture characteristics, surgical details, and radiographic data were collected...
April 23, 2024: BMC Musculoskeletal Disorders
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