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R Rodríguez-Blanco, M Álvarez-García, C Villalibre-Calderón, L D Piña-Ferreras, S Junquera-Alonso, J C Alonso-Lorenzo
INTRODUCTION: The aim of this study is to determine the rate of potentially inappropriate prescriptions (PIP) in people older than 64 years of age in Avilés, Asturias, Spain. MATERIALS AND METHODS: A descriptive cross-sectional study was conducted in six Health Care Centres. A sample of 400 people was selected, obtained by a random sampling proportional to the population registered in each Health Centre. A review was made of the computerised clinical records, and the STOPP-START (version 2014 with 114 items) criteria were applied to evaluate the PIP...
December 10, 2018: Semergen
Kathrin Heldmaier, Christian Stoppe, Andreas Goetzenich, Ann-Christina Foldenauer, Rachat Zayat, Thomas Breuer, Gereon Schälte
Background: Aortic valve stenosis has gained increasingly more importance due to its high prevalence in elderly people. More than two decades ago, transcatheter aortic valve replacement emerged for patients who were denied surgery, and its noninferiority has been demonstrated in numerous studies. Oxidative stress has generated great interest because of its sensitivity to cell damage and the possibility of offering early hints of clinical outcomes. The aim of the present study was to investigate whether there is a significant difference between transcatheter (TAVR) or surgical aortic valve replacement (SAVR) in terms of the changes in oxidation-reduction potential (ORP) and antioxidant capacity...
2018: BioMed Research International
Christian Stoppe, Julia Ney, Vladimir V Lomivorotov, Sergey M Efremov, Carina Benstoem, Aileen Hill, Ekaterina Nesterova, Elena Laaf, Andreas Goetzenich, Bernard McDonald, Arne Peine, Gernot Marx, Karl Fehnle, Daren K Heyland
BACKGROUND: Cardiovascular surgery patients with a prolonged intensive care unit (ICU) stay may benefit most from early nutrition support. Using established scoring systems for nutrition assessment and operative risk stratification, we aimed to develop a model to predict a prolonged ICU stay ≥5 days in order to identify patients who will benefit from early nutrition interventions. METHODS: This is a retrospective analysis of a prospective observational study of patients undergoing elective valvular, coronary artery bypass grafting, or combined cardiac surgery...
December 2, 2018: JPEN. Journal of Parenteral and Enteral Nutrition
Andreas D Meid, Andreas Groll, Dirk Heider, Sarah Mächler, Jürgen-Bernhard Adler, Christian Günster, Hans-Helmut König, Walter E Haefeli
OBJECTIVES: To develop and internally validate prediction models for medication-related risks arising from overuse, misuse, and underuse that utilize clinical context information and are suitable for routine risk assessment in claims data (i.e., medication-based models predicting the risk for hospital admission apparent in routine claims data or MEDI-RADAR). METHODS: Based on nationwide claims from health-insured persons in Germany between 2010 and 2012, we drew a random sample of people aged ≥65 years (N = 22,500 randomly allocated to training set, N = 7500 to validation set)...
December 2018: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
Bianca F Nieves-Pérez, Sullynette Guerrero-De Hostos, Mariela I Frontera-Hernández, Iadelisse Cruz González, José Josué Hernández Muñoz
OBJECTIVES: Prevalence of potentially inappropriate medications (PIMs) and potential prescribing omissions (PPOs). DESIGN: Cross-sectional study through review of residents' records. SETTING: Three nursing homes of Puerto Rico's metropolitan area. PARTICIPANTS: Nursing home residents. INTERVENTION: Records of residents 65 years of age and older with documented medications and chronic diseases were reviewed. Hospitalized and hospice/palliative care residents were excluded. Beers criteria-2015 and START-STOPP criteria-2014 were applied to identify PIMs and PPOs...
November 1, 2018: Consultant Pharmacist: the Journal of the American Society of Consultant Pharmacists
Pascal L Langlois, William Manzanares, Neill K J Adhikari, François Lamontagne, Christian Stoppe, Aileen Hill, Daren K Heyland
Vitamin C, an enzyme cofactor and antioxidant, could hasten the resolution of inflammation, oxidative stress, and microvascular dysfunction. While observational studies have demonstrated that critical illness is associated with low levels of vitamin C, randomized controlled trials (RCTs) of vitamin C, alone or in combination with other antioxidants, have yielded contradicting results. We searched MEDLINE, EMBASE, CINAHL, and the Cochrane Central Register of Controlled Trials (inception to December 2017) for RCTs comparing vitamin C, by enteral or parenteral routes, with placebo or none, in intensive care unit (ICU) patients...
November 19, 2018: JPEN. Journal of Parenteral and Enteral Nutrition
Teresa Pérez, Frank Moriarty, Emma Wallace, Ronald McDowell, Patrick Redmond, Tom Fahey
OBJECTIVE: To determine whether hospital admission is associated with potentially inappropriate prescribing among older primary care patients (aged ≥65 years) and whether such prescribing was more likely after hospital admission than before. DESIGN: Longitudinal study of retrospectively extracted data from general practice records. SETTING: 44 general practices in Ireland in 2012-15. PARTICIPANTS: Adults aged 65 years or over attending participating practices...
November 14, 2018: BMJ: British Medical Journal
Richard S Garner, Rakib U Rayhan, James N Baraniuk
One third of Gulf War Illness (GWI) subjects in a recent study were found to develop transient postural tachycardia after submaximal exercise stress tests. Post-exercise postural tachycardia is a previously undescribed physiological finding. A new GWI cohort was studied to verify this novel finding and characterize this cardiovascular phenomenon. Subjects followed the same protocol as before. The change in heart rate between recumbent and standing postures (ΔHR) was measured before exercise, and after submaximal bicycle exercise...
2018: American Journal of Translational Research
Josefin Soppert, Sandra Kraemer, Christian Beckers, Luisa Averdunk, Julia Möllmann, Bernd Denecke, Andreas Goetzenich, Gernot Marx, Jürgen Bernhagen, Christian Stoppe
Background Although macrophage migration inhibitory factor ( MIF ) has been demonstrated to mediate cardioprotection in ischemia/reperfusion injury and antagonize fibrotic effects through its receptor, CD 74, the function of the soluble CD 74 receptor ectodomain ( sCD 74) and its interaction with circulating MIF have not been explored in cardiac disease. Methods and Results Cardiac fibroblasts were isolated from hearts of neonatal mice and differentiated into myofibroblasts. Co-treatment with recombinant MIF and sCD 74 induced cell death ( P<0...
September 4, 2018: Journal of the American Heart Association
Christian Schinke, Swen Hesse, Michael Rullmann, Georg-Alexander Becker, Julia Luthardt, Franziska Zientek, Marianne Patt, Muriel Stoppe, Elisa Schmidt, Klara Meyer, Philipp M Meyer, Johannes Orthgieß, Matthias Blüher, Jürgen Kratzsch, Yu-Shin Ding, Florian Then Bergh, Osama Sabri
The central noradrenaline (NA) stress-response network co-mediates hypothalamic-pituitary-adrenal (HPA) axis activation and arginine-vasopressin (AVP) release. Dysregulation of these systems contributes to stress-related diseases such as human obesity, but their interrelation remains unclear. The study was aimed to test for the first time in vivo whether central noradrenergic activity quantitatively indexed by the availability of the presynaptic NA transporter (NAT) is associated with HPA axis responsiveness as measured with the combined dexamethasone suppression/corticotropin releasing hormone stimulation (dex/CRH) test and copeptin as a surrogate marker of the serum AVP tone in highly obese, otherwise, healthy individuals compared to age- and sex-matched non-obese, healthy controls...
October 29, 2018: Stress: the International Journal on the Biology of Stress
Lynn Gers, Mirko Petrovic, Stany Perkisas, Maurits Vandewoude
Objectives: Antidepressant use increases as age rises. Moreover, older patients are more sensitive to side effects and drug interactions. This descriptive study aims to map antidepressant use among patients at the geriatrics department of a university hospital and to evaluate whether prescribing happens in an evidence-based manner. Methods: Patients aged 75 years and over, admitted to the geriatrics department of the Middelheim Hospital in Antwerp between February and July 2017 were included...
August 2018: Therapeutic Advances in Drug Safety
Michael Feichtinger, Veronica Falcone, Theresa Schoenleitner, Tina Stopp, Peter Wolf Husslein, Wolfgang Eppel, Kinga M Chalubinski, Christian S Göbl
PURPOSE:  To investigate intrauterine fetal growth development and birth anthropometry of fetuses conceived after maternal gastric bypass surgery. MATERIALS AND METHODS:  Longitudinal cohort study describing longitudinal growth estimated by ultrasound on 43 singleton pregnancies after gastric bypass compared to 43 BMI-matched controls. RESULTS:  In fetuses after maternal gastric bypass surgery, growth percentiles decreased markedly from the beginning of the second trimester until the end of the third trimester (decrease of 3...
October 25, 2018: Ultraschall in der Medizin
Sebastian Wendt, Andreas Goetzenich, Claudia Goettsch, Christian Stoppe, Christian Bleilevens, Sandra Kraemer, Carina Benstoem
Cardiovascular diseases are the main cause of death worldwide, demanding new treatments and interventions. Recently, extracellular vesicles (EVs) came in focus as important carriers of protective molecules such as miRNAs and proteins which might contribute to e.g. improved cardiac function after myocardial infarction. EVs can be secreted from almost every cell type in the human body and can be transferred via the bloodstream in almost every compartment. To provide an all-encompassing overview of studies investigating these beneficial properties of EVs we performed a systematic review/meta-analysis of studies investigating the cardioprotective characteristics of EVs...
October 24, 2018: Scientific Reports
Samantha C Butler, Anjali Sadhwani, Christian Stopp, Jayne Singer, David Wypij, Carolyn Dunbar-Masterson, Janice Ware, Jane W Newburger
OBJECTIVE: Mortality rates for children with congenital heart disease (CHD) have significantly declined, resulting in a growing population with associated neurodevelopmental disabilities. American Heart Association guidelines recommend systematic developmental screening for children with CHD. The present study describes results of inpatient newborn neurodevelopmental assessment of infants after open heart surgery. OUTCOME MEASURES: We evaluated the neurodevelopment of a convenience sample of high-risk infants following cardiac surgery but before hospital discharge using an adaptation of the Newborn Behavioral Observation...
October 15, 2018: Congenital Heart Disease
Rashad Zayat, Usaama Ahmad, Christian Stoppe, Mohammad Amen Khattab, Fateh Arab, Ajay Moza, Lachmandath Tewarie, Andreas Goetzenich, Rüdiger Autschbach, Heike Schnoering
Low-level hemolysis (LLH) after left ventricular assist device implantation contributes to thromboembolic events (TE). Free plasma hemoglobin (fHb) scavenges nitric oxide (NO), which causes endothelial dysfunction and activates platelets. fHb also interacts with von Willebrand factor (vWF). We hypothesized that improved hemodynamic and enhanced NO signaling in HeartMate II (HMII) patients with LLH taking the phosphodiesterase-5 inhibitor sildenafil may reduce the risk of TE.From 2011 to 2015, 83 patients underwent HMII implantation...
October 10, 2018: International Heart Journal
Shanna C Trenaman, Barbara J Hill-Taylor, Kara J Matheson, David M Gardner, Ingrid S Sketris
Purpose: Despite well-established concerns regarding adverse drug effects, antipsychotics are frequently prescribed for older adults. Our first objective was to identify trends in antipsychotic dispensations to older Nova Scotians. STOPP (Screening Tool of Older Persons' Potentially Inappropriate Prescriptions) criteria identify antipsychotic use in those with a history of falls as potentially inappropriate. Our second objective was to identify trends, predictors, and adherence with this STOPP criteria by identifying continued antipsychotic dispensations following a fall-related hospitalization...
2018: Current Therapeutic Research, Clinical and Experimental
Victoria K Robson, Christian Stopp, David Wypij, Carolyn Dunbar-Masterson, David C Bellinger, David R DeMaso, Leonard A Rappaport, Jane W Newburger
OBJECTIVE: To examine associations between measurements of neurodevelopment and psychosocial health status at age 8 and 16 years in patients with repaired dextro-transposition of the great arteries. STUDY DESIGN: In the 16-year follow-up of the Boston Circulatory Arrest Study, 137 parents completed the Child Health Questionnaire-Parent Form-50, of whom 135 had completed the Child Health Questionnaire-Parent Form-50 when their child was age 8 years. Psychosocial and physical summary scores were used to assess change in health status from age 8 to 16 years...
September 28, 2018: Journal of Pediatrics
Jinhui Ma, Kerry Siminoski, Nathalie Alos, Jacqueline Halton, Josephine Ho, Elizabeth A Cummings, Nazih Shenouda, Mary Ann Matzinger, Brian Lentle, Jacob L Jaremko, Beverly Wilson, David Stephure, Robert Stein, Anne Marie Sbrocchi, Celia Rodd, Victor A Lewis, Caroline Laverdière, Sara Israels, Ronald M Grant, Conrad V Fernandez, David B Dix, Robert Couch, Elizabeth Cairney, Ronald Barr, Stephanie Atkinson, Sharon Abish, David Moher, Frank Rauch, Leanne M Ward
Objective: To assess the impact of vertebral fractures (VF) and glucocorticoid (GC) exposure on height deficits in children during treatment of acute lymphoblastic leukemia (ALL). Methods: Children with ALL treated without cranial radiation therapy (n = 160; median age 5.1 years; 58.1% male) were followed prospectively for six years. Spinal deformity index (SDI) was used to quantify VF status. Results: Baseline height Z-score was 0.3 ± 1...
September 20, 2018: Journal of Clinical Endocrinology and Metabolism
Paul E Tatum Iii, Shaida Talebreza, Jeanette S Ross
Family physicians should be proficient in geriatric assessment because, as society ages, older adults will constitute an increasing proportion of patients. Geriatric assessment evaluates medical, social, and environmental factors that influence overall well-being, and addresses functional status, fall risk, medication review, nutrition, vision, hearing, cognition, mood, and toileting. The Medicare Annual Wellness Visit includes the key elements of geriatric assessment performed by family physicians. Comprehensive geriatric assessment can lead to early recognition of problems that impair quality of life by identifying areas for focused intervention, but a rolling geriatric assessment over several visits can also effectively identify subtle or hidden problems...
June 15, 2018: American Family Physician
Alexander Gombert, Lukas Martin, Ann Christina Foldenauer, Clara Krajewski, Andreas Greiner, Drosos Kotelis, Christian Stoppe, Gernot Marx, Jochen Grommes, Tobias Schuerholz, Michael J Jacobs, Johannes Kalder
BACKGROUND: Neutrophil gelatinase-associated lipocalin (NGAL) has been described as a potential biomarker of acute kidney injury (AKI) in different settings, but its behaviour under influence of open and endovascular repair of thoraco-abdominal aortic aneurysms (TAAA) has not been assessed yet. In this study, the course of NGAL was observed and differences of serum- (sNGAL) and urine-NGAL (uNGAL) levels following TAAA repair, especially with regard to AKI, were evaluated. PATIENTS AND METHODS: In this retrospective single centre study, 52 patients (mean age 64...
September 10, 2018: VASA. Zeitschrift Für Gefässkrankheiten
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