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#1
Jan Hofland, Alexandre Ouattara, Manuella Schaller, Berthold Bein, Inge de Liefde, Jean-Luc Fellahi, Matthias Gruenewald, Jean Hazebroucq, Claude Ecoffey, Pierre Joseph, Matthias Heringlake, Annick Steib, Mark Coburn, Julien Amour, Bertrand Rozec, Patrick Meybohm, Benedikt Preckel, Jean-Luc Hanouz, Luigi Tritapepe, Peter Tonner, Hamina Benhaoua, Jan Patrick Roesner, Rob Tenbrinck, Ad Jjc Bogers, Bert G Mik, Alain Coiffic, Jochen Renner, Markus Steinfath, Helga Francksen, Ole Broch, Assad Haneya, Patrick Guinet, Lauren Daviet, Corinne Brianchon, Sebastien Rosier, Jean-Jacques Lehot, Hauke Paarmann, Julika Schön, Thorsten Hanke, Joachym Ettel, Silke Olsson, Stefan Klotz, Amir Samet, Giedrius Laurinenas, Adrien Thibaud, Mircea Cristinar, Olivier Collanges, François Levy, Rolf Rossaint, Ana Stevanovic, Gereon Schaelte, Christian Stoppe, Nora Ait Hamou, Sarah Hariri, Astrid Quessard, Aude Carillion, Hélène Morin, Jacqueline Silleran, David Robert, Anne-Sophie Crouzet, Kai Zacharowski, Christian Reyher, Sonja Iken, Nina C Weber, Marcus Hollmann, Susanne Eberl, Giovanni Carriero, Daria Collacchi, Alessandra Di Persio, Olivier Fourcade, Stefan Bergt, Angela Alms
No abstract text is available yet for this article.
September 2018: Anesthesiology
https://www.readbyqxmd.com/read/30087386/reduced-post-operative-dpp4-activity-associated-with-worse-patient-outcome-after-cardiac-surgery
#2
Heidi Noels, Wendy Theelen, Marieke Sternkopf, Vera Jankowski, Julia Moellmann, Sandra Kraemer, Michael Lehrke, Nikolaus Marx, Lukas Martin, Gernot Marx, Joachim Jankowski, Andreas Goetzenich, Christian Stoppe
Cardiac surgery with cardiopulmonary bypass (CPB) triggers myocardial ischemia/reperfusion injury contributing to organ dysfunction. Preclinical studies revealed that dipeptidyl peptidase (DPP4) inhibition is protective during myocardial infarction. Here, we assessed for the first time the relation of peri-operative DPP4-activity in serum of 46 patients undergoing cardiac surgery with patients' post-operative organ dysfunction during intensive care unit (ICU) stay. Whereas a prior myocardial infarction significantly reduced pre-operative DDP4-activity, patients with preserved left ventricular function showed an intra-operative decrease of DPP4-activity...
August 7, 2018: Scientific Reports
https://www.readbyqxmd.com/read/30083954/compromised-tdcs-induced-facilitation-of-motor-consolidation-in-patients-with-multiple-sclerosis
#3
Jost-Julian Rumpf, Sophie Dietrich, Muriel Stoppe, Christopher Fricke, David Weise, Florian Then Bergh, Joseph Classen
OBJECTIVE: To investigate whether consolidation after motor learning can be facilitated by offline (post-training) transcranial direct current stimulation (tDCS) in patients with multiple sclerosis (MS). METHODS: In this cross-sectional double-blind interventional study, effects of tDCS on motor consolidation were examined in 14 patients with relapsing remitting MS [median Expanded Disability Status Scale score 2.0 (range 1-4)] and 14 age- and sex-matched healthy controls...
August 6, 2018: Journal of Neurology
https://www.readbyqxmd.com/read/30061440/study-protocol-for-a-single-centre-prospective-non-blinded-randomised-12-month-parallel-group-superiority-study-to-compare-the-efficacy-of-pharmacist-intervention-versus-usual-care-for-elderly-patients-hospitalised-in-orthopaedic-wards
#4
Junpei Komagamine, Kenichi Sugawara, Miho Kaminaga, Shinpei Tatsumi
INTRODUCTION: Given that polypharmacy and potentially inappropriate prescribing are common in elderly orthopaedic patients, pharmacist interventions to improve medication practices among this population are important. However, past studies have reported mixed results regarding the effectiveness of pharmacist-led interventions in inpatient elderly care. Furthermore, few randomised controlled trials have evaluated patient-relevant outcomes as a primary endpoint. Therefore, we will evaluate whether a pharmacist-led intervention could reduce readmission of hospitalised elderly orthopaedic patients with polypharmacy or potentially inappropriate prescribing...
July 30, 2018: BMJ Open
https://www.readbyqxmd.com/read/30060468/vitamin-c-to-improve-organ-dysfunction-in-cardiac-surgery-patients-review-and-pragmatic-approach
#5
REVIEW
Aileen Hill, Sebastian Wendt, Carina Benstoem, Christina Neubauer, Patrick Meybohm, Pascal Langlois, Neill Kj Adhikari, Daren K Heyland, Christian Stoppe
The pleiotropic biochemical and antioxidant functions of vitamin C have sparked recent interest in its application in intensive care. Vitamin C protects important organ systems (cardiovascular, neurologic and renal systems) during inflammation and oxidative stress. It also influences coagulation and inflammation; its application might prevent organ damage. The current evidence of vitamin C's effect on pathophysiological reactions during various acute stress events (such as sepsis, shock, trauma, burn and ischemia-reperfusion injury) questions whether the application of vitamin C might be especially beneficial for cardiac surgery patients who are routinely exposed to ischemia/reperfusion and subsequent inflammation, systematically affecting different organ systems...
July 27, 2018: Nutrients
https://www.readbyqxmd.com/read/30056012/potentially-inappropriate-prescribing-in-belgian-nursing-homes-prevalence-and-associated-factors
#6
Pauline M S Anrys, Goedele C Strauven, Veerle Foulon, Jean-Marie Degryse, Séverine Henrard, Anne Spinewine
BACKGROUND/OBJECTIVES: Our aim was to describe the prevalence of potentially inappropriate medications (PIMs) and potential prescribing omissions (PPOs) in Belgian nursing homes and to identify characteristics of residents, general practitioners (GPs), and nursing homes (NHs) that are associated with the number of PIMs and PPOs. DESIGN: A cross-sectional study. SETTING: and Participants: Nursing home residents (NHRs), aged ≥65 years, not in palliative care were included in 54 Belgian NHs participating in the COME-ON study...
July 25, 2018: Journal of the American Medical Directors Association
https://www.readbyqxmd.com/read/29998925/retrospective-analysis-of-air-handling-by-contemporary-oxygenators-in-the-setting-of-cardiac-surgery
#7
Carina Benstoem, Bleilevens Christian, Borchardt Ralf, Stoppe Christian, Goetzenich Andreas, Autschbach Ruedriger, Breuer Thomas
PURPOSE: Cardiac surgery with the use of extracorporeal circulation is associated with a significant risk for gaseous microemboli (GME) despite excellent surgical techniques and highest operative standards. GME are associated with postoperative neurocognitive dysfunction and negative clinical outcome. This study determines whether oxygenator design has influence on perioperative outcome after cardiac surgery. METHODS: Three different oxygenator models with integrated arterial filter (HiliteAF 7000, Fusion Affinity, and Synthesis) were retrospectively evaluated in 55 patients undergoing elective cardiac surgery with the use of extracorporeal circulation...
July 11, 2018: Annals of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/29970005/medication-review-versus-usual-care-to-improve-drug-therapies-in-older-inpatients-not-admitted-to-geriatric-wards-a-quasi-experimental-study-rasp-igct
#8
Lorenz Van der Linden, Julie Hias, Lisa Dreessen, Koen Milisen, Johan Flamaing, Isabel Spriet, Jos Tournoy
BACKGROUND: Interdisciplinary geriatric consultation teams (IGCT) are regularly requested to provide comprehensive geriatric assessments in older inpatients. Our primary aim was to evaluate whether medication reviews increased the number of IGCT-provided drug-related recommendations. Secondary aims were to reduce the number of potentially inappropriate medications (PIMs), and to identify the acceptance rate of and determinants for the number of recommendations. METHODS: A before-after study was performed in older inpatients not admitted to acute geriatric wards...
July 3, 2018: BMC Geriatrics
https://www.readbyqxmd.com/read/29969992/identifying-drug-substances-of-screening-tool-for-older-persons-appropriate-prescriptions-for-japanese
#9
Kaori Nomura, Taro Kojima, Shinya Ishii, Takuto Yonekawa, Masahiro Akishita, Manabu Akazawa
BACKGROUND: In 2015, the Japan Geriatric Society (JGS) updated "the Guidelines for Medical Treatment and its Safety in the elderly," accompanied with the Screening Tool for Older Persons' Appropriate Prescriptions for Japanese (STOPP-J): "drugs to be prescribed with special caution" and "drugs to consider starting." The JGS proposed the STOPP-J to contribute to improving prescribing quality; however, each decision should be carefully based on medical knowledge...
July 3, 2018: BMC Geriatrics
https://www.readbyqxmd.com/read/29958151/assessment-of-potentially-inappropriate-medications-in-elderly-according-to-beers-2015-and-stopp-criteria-and-their-association-with-treatment-satisfaction
#10
Stephanie Sakr, Souheil Hallit, Maria Haddad, Lydia Rabbaa Khabbaz
OBJECTIVE: To assess and compare, according to Beers and STOPP criteria, the frequency and causes of potentially inappropriate medications (PIMs) in elderly, as well as the relationship between PIMs use and patient's treatment satisfaction, evaluated using the Treatment Satisfaction Questionnaire for Medications (TSQM). METHOD: 350 patients (mean age = 73.49 years), taking a total of 1893 medications, were enrolled from community pharmacies. RESULTS: 6...
September 2018: Archives of Gerontology and Geriatrics
https://www.readbyqxmd.com/read/29945432/volatile-anaesthetics-versus-propofol-in-the-cardiac-surgical-setting-of-remote-ischaemic-preconditioning-a-secondary-analysis-of-a-cochrane-systematic-review
#11
Carina Benstoem, Andreas Goetzenich, Rüdiger Autschbach, Gernot Marx, Christian Stoppe, Thomas Breuer
INTRODUCTION: So far, the concept of remote ischaemic preconditioning (RIPC) failed its translation from experimental to clinical studies. In addition to our Cochrane Systematic Review, we systematically assessed the use of the intravenous anaesthetic propofol, as a potential confounding factor. EVIDENCE ANALYSIS: We searched CENTRAL, MEDLINE, Embase and Web of Science. We included randomised controlled trials comparing RIPC with no RIPC in adult patients scheduled for coronary artery bypass graft surgery (with or without valve surgery) receiving either exclusively propofol or exclusively volatile anaesthetics...
June 26, 2018: Minerva Anestesiologica
https://www.readbyqxmd.com/read/29945287/-role-of-nutrition-support-in-cardiac-surgery-patients-an-overview
#12
Aileen Hill, Andreas Goetzenich, Gernot Marx, Christian Stoppe
Cardiac surgery patients regularly experience a systemic inflammation response to the surgery and a postoperative stay in the intensive care unit. Nutritional support is one strategy to improve the outcome of cardiosurgical patients. A preoperatively diagnosed malnutrition contributes to a higher morbidity and mortality in this patient group. Preoperative fasting, glucose-free infusions during long and invasive operations and delayed postoperative nutrition therapy aggravate the nutrition situation. However, conclusive evidence for this population, consisting of well-conducted clinical trials is lacking...
June 2018: Anästhesiologie, Intensivmedizin, Notfallmedizin, Schmerztherapie: AINS
https://www.readbyqxmd.com/read/29934026/altered-white-matter-microstructure-correlates-with-iq-and-processing-speed-in-children-and-adolescents-post-fontan
#13
Christopher G Watson, Christian Stopp, David Wypij, David C Bellinger, Jane W Newburger, Michael J Rivkin
OBJECTIVE: To compare white matter microstructure in children and adolescents with single ventricle who underwent the Fontan procedure with healthy controls, and to explore the association of white matter injury with cognitive performance as well as patient and medical factors. STUDY DESIGN: Fontan (n = 102) and control subjects (n = 47) underwent diffusion tensor imaging (DTI) at ages 10-19 years. Mean DTI measures (fractional anisotropy, radial diffusivity, axial diffusivity, and mean diffusivity) were calculated for 33 fiber tracts from standard white matter atlases...
June 19, 2018: Journal of Pediatrics
https://www.readbyqxmd.com/read/29916139/contribution-of-patient-interviews-as-part-of-a-comprehensive-approach-to-the-identification-of-drug-related-problems-on-geriatric-wards
#14
Dominik Stämpfli, Fabienne Boeni, Andy Gerber, Victor A D Bättig, Kurt E Hersberger, Markus L Lampert
BACKGROUND: Inappropriate prescribing is linked to increased risks for adverse drug reactions and hospitalisation. Combining explicit and implicit criteria of inappropriate prescribing with the information obtained in patient interviews seems beneficial with regard to the identification of drug-related problems (DRPs) in hospitalised patients. OBJECTIVE: We aimed to investigate the inclusion of pharmacist interviews as part of medication reviews (including the use of explicit and implicit criteria of inappropriate prescribing) to identify DRPs in older inpatients...
June 19, 2018: Drugs & Aging
https://www.readbyqxmd.com/read/29903667/-the-most-common-stopp-start-criteria-in-spain-a-review-of-the-literature
#15
Esther Salgueiro, Bryana Candelaria Elizarde, Ana Isabel Elola, Beatriz García-Pulido, María Luisa Nicieza-García, Gloria Manso
OBJECTIVE: To analyse STOPP/START criteria found most frequently in the studies carried out in Spain, in order to identify the main areas of potentially inappropriate prescribing. METHODS: A literature review was carried out on the original studies performed in Spain that applied the original version of the STOPP/START criteria and that described the most common STOPP and/or START criteria found. In each study, a weighted analysis was performed on the criteria found, by assigning 5 points to the criterion in first position, 4 points to the criterion in second position, and so on to fifth criterion...
June 11, 2018: Revista Española de Geriatría y Gerontología
https://www.readbyqxmd.com/read/29877182/potentially-inappropriate-prescribing-in-elderly-patient-analyze-before-after-hospitalization
#16
Ludovic Argoullon, Marie-Agnès Manciaux, Aude Valance, Amélie Bonneville
In the context of improved medication management in the elderly patient, we were interested in the reevaluation of drug prescription during hospitalization. The aim of this study is to assess the prevalence of inappropriate prescribing in the elderly patient before and after hospitalization. PATIENTS AND METHODS: This is a descriptive and retrospective study of drug prescriptions in a non-geriatric unit. Prescriptions were analyzed using STOPP/START tool. RESULTS: Seventy-two patients over 65 years-old were included...
June 1, 2018: Gériatrie et Psychologie Neuropsychiatrie du Vieillissement
https://www.readbyqxmd.com/read/29847341/nutritional-support-in-patients-with-extracorporeal-life-support-and-ventricular-assist-devices
#17
Christian Stoppe, Ekaterina Nesterova, Gunnar Elke
PURPOSE OF REVIEW: Extracorporeal life support (ECLS) including venovenous and venoarterial extracorporeal membrane oxygenation (ECMO) and ventricular assist devices (VAD) provide mechanical pulmonary and circulatory support, respectively, in patients with acute pulmonary or cardiovascular failure. This review discusses recently published data regarding specific topics of nutritional support in patients with ECLS and VAD. RECENT FINDINGS: ECLS may aggravate loss of endogenous and exogenous micronutrients and macronutrients...
August 2018: Current Opinion in Critical Care
https://www.readbyqxmd.com/read/29794685/function-applicability-and-properties-of-a-novel-flexible-total-ossicular-replacement-prosthesis-with-a-silicone-coated-ball-and-socket-joint
#18
Thomas Stoppe, Matthias Bornitz, Nikoloz Lasurashvili, Kirsten Sauer, Thomas Zahnert, Karim Zaoui, Thomas Beleites
HYPOTHESIS: A total ossicular replacement prosthesis (TORP) with a silicone coated ball and socket joint (BSJ) is able to compensate pressure changes and therefore provide better sound transmission compared with rigid prostheses. BACKGROUND: Dislocation and extrusion are known complications after TORP reconstruction, leading to revisions and recurrent hearing loss. Poor aeration of the middle ear, scar tension, and static pressure variations in conjunction with rigid prosthesis design causes high tension at the implant coupling points...
July 2018: Otology & Neurotology
https://www.readbyqxmd.com/read/29786884/bone-morbidity-and-recovery-in-children-with-acute-lymphoblastic-leukemia-results-of-a-six-year-prospective-cohort-study
#19
Leanne M Ward, Jinhui Ma, Bianca Lang, Josephine Ho, Nathalie Alos, Mary Ann Matzinger, Nazih Shenouda, Brian Lentle, Jacob L Jaremko, Beverly Wilson, David Stephure, Robert Stein, Anne Marie Sbrocchi, Celia Rodd, Victor Lewis, Sara Israels, Ronald M Grant, Conrad V Fernandez, David B Dix, Elizabeth A Cummings, Robert Couch, Elizabeth Cairney, Ronald Barr, Sharon Abish, Stephanie A Atkinson, John Hay, Frank Rauch, David Moher, Kerry Siminoski, Jacqueline Halton
Osteoporotic fractures are a significant cause of morbidity in acute lymphoblastic leukemia (ALL). Our objective was to determine the incidence and predictors of fractures and recovery from osteoporosis in pediatric ALL over 6 years following glucocorticoid initiation. Vertebral fractures (VF) and vertebral body reshaping were assessed on annual spine radiographs, low-trauma non-VF were recorded at regular intervals and spine bone mineral density (BMD) was captured every 6 months for 4 years and then annually...
May 22, 2018: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/29778885/effects-of-hyperpolypharmacy-and-potentially-inappropriate-medications-pims-on-functional-decline-in-older-patients-discharged-from-acute-care-hospitals
#20
Paolo Fabbietti, Carmelinda Ruggiero, Federica Sganga, Sergio Fusco, Federica Mammarella, Norma Barbini, Laura Cassetta, Graziano Onder, Andrea Corsonello, Fabrizia Lattanzio, Mirko Di Rosa
AIM: To comparatively investigate the effects of hyperpolypharmacy and potentially inappropriate medications (PIMs) on functional decline in older patients after hospital discharge. METHODS: Our series consisted of 733 patients aged ≥65 consecutively enrolled in a multicenter observational longitudinal study. PIMs were defined on the basis of updated versions of Beers and STOPP criteria. The occurrence of functional decline was defined as the loss of independency in at least 1 basic activity of daily living (BADL) from discharge through 3-month follow-up visit...
July 2018: Archives of Gerontology and Geriatrics
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